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Bach Quang Le, Clemens Van Blitterswijk, Jan De Boer
Devitalized hypertrophic cartilage matrix (DCM) is an attractive concept for an off-the-shelf bone graft substitute. Upon implantation, DCM can trigger the natural endochondral ossification process, but only when the hypertrophic cartilage matrix has been reconstituted correctly. In vivo hypertrophic differentiation has been reported for multiple cell types but up-scaling and in vivo devitalization remain a big challenge. To this end, we developed a micro tissue-engineered cartilage (MiTEC) model using the chondrogenic cell line ATDC5...
April 20, 2017: Bioengineering
J P Baguet, R Asmar, P Valensi, S Nisse-Durgeat, J M Mallion
In hypertension and diabetes, early structural changes of the arterial wall precede or support atherosclerosis. There is evidence that some antihypertensive drugs exert an antiathero-sclerotic effect. Over 36 months, we investigated the effect of candesartan cilexetil (CC) on the common carotid intima-media thickness (IMT) vs amlodipine besylate (AML) in patients with type 2 diabetes and mild to moderate essential hypertension. After a 4-week wash-out period, 209 patients were randomized to either CC 8 mg or AML 5 mg once daily for a minimum of 1 month, after which, if BP was not normalized, the dosage was doubled, followed by the addition of hydrochlorothiazide 12...
2009: Vascular Health and Risk Management
Lee D Kaplan, John M Ernsthausen, James P Bradley, Freddie H Fu, Daniel L Farkas
PURPOSE: The purpose of this experimental study was to evaluate the thermal field produced with monopolar and bipolar radiofrequency probes located at increasing heights from the target treatment site. TYPE OF STUDY: Experimental study. METHODS: Two bipolar (ACD-50, ArthroCare, Sunnyvale, CA; VAPR-TC, Mitec Surgical Products, Westwood, MA) and one monopolar (Vulcan TAC-C II, Oratec Interventions, Menlo Park, CA) radiofrequency probes were placed in a screw-driven stage that allowed for 0...
July 2003: Arthroscopy: the Journal of Arthroscopic & related Surgery
U Jørgensen, H Svend-Hansen, K Bak, I Pedersen
A total of 41 consecutive patients (11 women and 30 men, median age 29 (18-51) years) with unilateral, isolated, posttraumatic, recurrent anterior shoulder dislocation and a Bankart lesion were operatively repaired, either by an arthroscopic technique including a capsular plication, or by an open procedure with Mitec anchors. All the patients were followed prospectively and evaluated after a median of 36 (30-52) months follow-up by a "blind" observer. Nineteen patients in each group had excellent or good results, and one in each group was graded as fair...
1999: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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