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https://www.readbyqxmd.com/read/29338788/high-throughput-immunophenotypic-characterization-of-bone-marrow-and-cord-blood-derived-mesenchymal-stromal-cells-reveals-common-and-differentially-expressed-markers-identification-of-angiotensin-converting-enzyme-cd143-as-a-marker-differentially-expressed
#1
Eliana Amati, Omar Perbellini, Gianluca Rotta, Martina Bernardi, Katia Chieregato, Sabrina Sella, Francesco Rodeghiero, Marco Ruggeri, Giuseppe Astori
BACKGROUND: Mesenchymal stromal cells (MSC) are a heterogeneous population of multipotent progenitors used in the clinic because of their immunomodulatory properties and their ability to differentiate into multiple mesodermal lineages. Although bone marrow (BM) remains the most common MSC source, cord blood (CB) can be collected noninvasively and without major ethical concerns. Comparative studies comprehensively characterizing the MSC phenotype across several tissue sources are still lacking...
January 16, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29338280/variable-skeletal-anatomical-features-of-acromegaly-in-the-skull-and-craniocervical-junction
#2
Maria Piagkou, Othon Manolakos, Theodore Troupis, Nikolaos Lazaridis, Konstantinos Laios, Alexandros Samolis, Konstantinos Natsis
OBJECTIVE: This study adds important information regarding the morphological alterations caused by growth hormone hypersecretion in the skull and craniocervical junction (CCJ). A variably asymmetric skull due to acromegaly coexists with expansion of the paranasal sinuses and multiple Wormian bones. CASE REPORT: A pathologically asymmetric dry skull of a European male, aged 38 years at death, with cranial vault and skull base thickening is described. The extensive paranasal sinus pneumatization caused a generalized thinning of the bony walls...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29333751/identification-of-the-minimal-glycotope-of-streptococcus-pneumoniae-7f-capsular-polysaccharide-using-synthetic-oligosaccharides
#3
Petra Menova, Mauro Sella, Katrin Sellrie, Claney Pereira, Peter H Seeberger
Streptococcus pneumoniae causes life-threatening diseases including meningitis, pneumonia and sepsis. Existing glycoconjugate vaccines based on purified capsular polysaccharides are widely used and help to prevent millions of deaths every year. Here, we report total synthesis of oligosaccharides resembling portions of the S. pneumoniae serotype 7F (ST7F) capsular polysaccharide repeating unit. To define minimal glycan epitopes, glycan microarrays containing the synthetic oligosaccharides were used to screen human reference serum and revealed that both side chains of the ST7F play a key role in antigen recognition...
January 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29325251/-extrapleural-solitary-fibrous-tumor-with-uncommon-histology-a-clinicopathologic-analysis-of-7-cases
#4
M Zhao, Z R Yang, Y B Wang, Y Chen, G W Qi, Y J Yan, W J Xu, G Q Ru, X L He
Objective: To investigate the clinicopathologic characteristics, immunophenotypes, and differential diagnostic features of extra-pleural solitary fibrous tumor (SFT) with uncommon histology. Methods: Seven cases of extra-pleural SFT with uncommon histology were collected during January 2015 and December 2016 in Zhejiang Provincal People's Hospital; the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed. EnVision method was used for immunohistochemical staining of STAT6, CD34 and other differential diagnosis associated markers...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29323624/sella-turcica-bridging-and-ossified-carotico-clinoid-ligament-correlation-with-sex-and-age
#5
Daniele Gibelli, Michaela Cellina, Stefano Gibelli, Marta Panzeri, Antonio Giancarlo Oliva, Giovanni Termine, Chiarella Sforza
Aim Sella turcica bridging and ossified carotico-clinoid ligament are two variants of the sella turcica, the origin of which is partially unknown. These variations should be properly recognised, as they may hamper the removal of the anterior clinoid process in surgical procedures. Therefore, our aim was to determine the prevalence of these two anatomical variants and to investigate their prevalence according to patient sex and age in a series of maxilla computed tomography scans. Materials and methods We revised 300 computed tomography scans of the head from northern Italian patients, stratified into three age groups (18-40 years, 41-60 years, >60 years): a logistic regression analysis was used to explore an association of sella turcica bridging with age and sex through Matlab software, also including a test for the extracted model ( P < 0...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29301674/influence-of-cooling-temperature-in-sperm-subpopulations-of-domestic-cats
#6
REVIEW
Anne Kemmer Souza, Luiz Guilherme Corsi Trautwein, Cristiane Sella Paranzini, Felipe Montanheiro Perencin, Guilherme Schiess Cardoso, Maria Isabel Mello Martins
The objective of this study was to identify and compare domestic feline sperm subpopulations, chilled at -1 °C for 24 and 48 h, as well as to analyze the sperm frequency in different subpopulations. Ten adult cats were used. Sperm collection was performed using electroejaculation (EEJ). Spermatic kinetics were evaluated using a computerized system at three moments: fresh, 24 and 48 h after refrigeration. The ejaculates were divided into a group refrigerated at -1 °C (n = 5,) and a group refrigerated at 4 °C (n = 5),...
December 22, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29300827/miic-online-a-web-server-to-reconstruct-causal-or-non-causal-networks-from-non-perturbative-data
#7
Nadir Sella, Louis Verny, Guido Uguzzoni, Séverine Affeldt, Hervé Isambert
Summary: We present a web server running the MIIC algorithm, a network learning method combining constraint-based and information-theoretic frameworks to reconstruct causal, non-causal or mixed networks from non-perturbative data, without the need for an a priori choice on the class of reconstructed network. Starting from a fully connected network, the algorithm first removes dispensable edges by iteratively subtracting the most significant information contributions from indirect paths between each pair of variables...
December 29, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29291184/predictors-of-favorable-soft-tissue-profile-outcomes-following-class-ii-twin-block-treatment
#8
Ji-Eun Kim, Su-Jung Mah, Tae-Woo Kim, Su-Jung Kim, Ki-Ho Park, Yoon-Goo Kang
Objective: The aim of this study was to determine cephalometric factors that help predict favorable soft-tissue profile outcomes following treatment with the Class II Twin-block appliance. Methods: Pre- and post-treatment lateral cephalograms of 45 patients treated with the Class II Twin-block appliance were retrospectively analyzed. Profile silhouettes were drawn from the cephalograms and evaluated by three orthodontists in order to determine the extent of improvement...
January 2018: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/29286362/dissection-and-coronal-slice-preparation-of-developing-mouse-pituitary-gland
#9
Dongmei Cao, Xianhua Ma, Weiping J Zhang, Zhifang Xie
The pituitary gland or hypophysis is an important endocrine organ secreting hormones essential for homeostasis. It consists of two glands with separate embryonic origins and functions - the neurohypophysis and the adenohypophysis. The developing mouse pituitary gland is tiny and delicate with an elongated oval shape. A coronal section is preferred to display both the adenohypophysis and neurohypophysis in a single slice of the mouse pituitary. The goal of this protocol is to achieve proper pituitary coronal sections with well-preserved tissue architectures from developing mice...
November 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29284879/a-comparison-of-dexmedetomidine-and-clonidine-in-attenuating-the-hemodynamic-responses-at-various-surgical-stages-in-patients-undergoing-elective-transnasal-transsphenoidal-resection-of-pituitary-tumors
#10
Summaira Jan, Zulfiqar Ali, Yasir Nisar, Imtiaz Ahmad Naqash, Syed Amer Zahoor, Shabir Ahmad Langoo, Khan Azhar
Background: Transsphenoidal approach to pituitary tumors is a commonly performed procedure with the advantage of a rapid midline access to the sella with minimal complications. It may be associated with wide fluctuations in hemodynamic parameters due to intense noxious stimulus at various stages of the surgery. As duration of the surgery is short and the patients have nasal packs, it is prudent to use an anesthestic technique with an early predictable recovery. Materials and Methods: A total of 60 patients of either sex between 18 and 65 years of age, belonging to the American Society of Anesthesiologists I and II who were undergoing elective transnasal transsphenoidal pituitary surgery were chosen for this study...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29249540/a-morphometric-and-analytical-cadaver-dissection-study-of-a-tumor-simulation-balloon-model
#11
Baran Bozkurt, Evgenii Belykh, Kaan Yağmurlu, Abhishek Agrawal, Steve W Chang, Michael S Staren, Robert F Spetzler, Joseph M Zabramski, Mark C Preul
We quantified the effects on anatomical cadaver dissection of a balloon-inflation tumor model positioned in the parasellar region and approached through an orbitozygomatic (OZ) craniotomy. A modified supraorbital OZ was performed bilaterally on 5 silicon-injected cadaver heads. Ten predetermined anatomical points assigned using a frameless stereotactic device were used to measure the working area of exposure, degree of surgical freedom, and horizontal and vertical angles of attack to specific target points before and after inflation of a balloon catheter mimicking a parasellar tumor...
December 14, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29242977/the-mechanism-in-junctional-failure-of-thoraco-lumbar-fusions-part-i-biomechanical-analysis-of-mechanisms-responsible-of-vertebral-overstress-and-description-of-the-cervical-inclination-angle-cia
#12
Jean-Charles Le Huec, Jonathon Richards, Andreas Tsoupras, Rachel Price, Amélie Léglise, Antonio A Faundez
PURPOSE: The purpose of the study is to describe the biomechanical theory explaining junctional breakdowns in thoraco-lumbar fusions, by taking the example of vertebral compression fractures. Also, a new angle, the cervical inclination angle (CIA), describing the relative position of the head at each vertebral level, is presented. METHODS: For the CIA, the data were collected from 137 asymptomatic subjects of a prospective database, containing clinical and radiologic informations...
December 14, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29236218/the-dangers-of-the-head-down-position-in-patients-with-untreated-pituitary-macroadenomas-case-series-and-review-of-literature
#13
Satoshi Kiyofuji, Avital Perry, Christopher S Graffeo, Caterina Giannini, Michael J Link
PURPOSE: Cavernous sinus syndrome is a rare phenomenon, characterized by simultaneous neuropathies of cranial nerves III-VI. Various pathological processes have been reported as precipitating etiologies, including infection, inflammation, vascular lesions, and neoplasms. PURPOSE: We report a unique case series of cavernous sinus syndrome attributable to prolonged Trendelenburg or prone positioning during non-cranial procedures and review the pertinent literature to enlighten on this rare but catastrophic phenomenon...
December 13, 2017: Pituitary
https://www.readbyqxmd.com/read/29216722/the-influence-of-orthodontic-non-extraction-treatment-on-the-change-in-the-inclination-and-position-of-incisors-in-the-europoid-race
#14
A Koniarova, E Sedlata Juraskova, M Spidlen, D Statelova
AIM: To detect post-treatment change in the inclination and position of incisors in cases treated with orthodontic non- extraction therapy. MATERIALS AND METHODS: The group consisted of 102 patients without extractions in lower and upper dental arch during orthodontic treatment. Cephalogram examination evaluated the position of the lower incisor to point A by Downs-pogonion line (-1 to APo) and inclination of the lower incisor to mandibular line (-1 to ML), position of the upper incisor to nasion-pogonion line (+1 to NPo), inclination of the upper incisor to nasion-sella line (+1 to NS) and the size of the inter-incisival angle between upper and central lower incisor (-1 to +1)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29207882/the-modified-lateral-supraorbital-approach
#15
Umit Kocaman, Tayfun Dalbasti, Mehmet Haluk Ozer, Hakan Yilmaz, Muhammet Bahadir Yilmaz, Ibrahim Burak Atci, Servet Celik
PURPOSE: Lateral supraorbital approach is a simpler and quicker method than pterional approach. It provides a more anterior projection when compared to the pterional approach. There are some minor differences of the modified lateral supraorbital approach when compared to lateral supraorbital approach. It is directed more subfrontally and anterior than the pterional and lateral supraorbital approach. MATERIAL AND METHODS: We used modified lateral supraorbital approach in 100 cases between 2012 and 2015 in Medical Park İzmir Hospital/Turkey...
December 6, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29204041/delayed-visual-loss-following-transcranial-surgery-for-tuberculum-sella-meningioma
#16
Sudha Menon, Girish Menon
Postoperative visual loss is a dreaded complication following transcranial excision of tuberculum sella meningioma. Visual deterioration is commonly noticed immediately after surgery, and delayed deterioration after 72 h is uncommon. We report a case of delayed postoperative deterioration in a 48-year-old female and discuss the possible mechanisms.
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29188303/analysis-of-petrous-apex-meningocele-associated-with-meningioma-is-there-any-relation-with-chronic-intracranial-hypertension
#17
Wan-Qun Yang, Jie-Ying Feng, Hong-Jun Liu, Biao Huang, Chang-Hong Liang
PURPOSE: Petrous apex meningocele (PAM) is an uncommon cystic lesion involving the petrous apex. The underlying cause of PAM may be related to chronic elevated intracranial pressure. The aim of the study was to explore the relationship between PAM and meningioma and between PAM and other intracranial hypertension findings. METHODS: Two hundred seventy-eight consecutive patients with meningiomas were retrospectively studied. Fifty age- and gender-matched controls were also enrolled in this study...
February 2018: Neuroradiology
https://www.readbyqxmd.com/read/29187947/macroprolactinemia-and-empty-sella-syndrome
#18
Ach Taieb, Kacem Njah Maha, Yosra Hasni El Abed, Amel Maaroufi Beizig, Molka Chaieb Chadli, Koussay Ach
Macroprolactinemia is a polymeric form of prolactin-release, causing mildly symptomatic clinical pictures. The former can be isolated or associated with other causes of hyperprolactinemia. The association with an empty sella syndrome is rare. We report a case of a female patient discovered with this association. It's about a female patient 47 years old, followed up since the age of 31 years for bilateral galactorrhea and a spaniomenorrhea. There has been no associated drug intake. Her exploration has showed a serum prolactin level of 635 mIU/L...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29174229/repair-of-cerebrospinal-fluid-leakage-using-a-transfrontal-radial-adipofascial-flap-an-individual-approach-supported-by-3d-printing-for-surgical-planning
#19
Stefan Grau, Stephanie Kellermann, Michael Faust, Moritz Perrech, Dirk Beutner, Alexander Drzezga, Joachim Zöller
BACKGROUND: Leakage of cerebrospinal fluid (CSF) due to large prolactinomas represents a complex issue. Due to limited anatomical space, often multiple leakage sites and scarce locally available tissue for repair, surgical possibilities are limited. We report an initial case of using a radial fasciocutaneous flap applied sub-frontally to cover a large skull base defect, supported by preoperative 3D-printing for surgical planning. CASE DESCRIPTION: A 29 year old female developed severe nuchal pain which was caused by destruction of large parts of her skull base by a prolactinoma...
November 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29158862/-epidermoid-cyst-in-the-sella-turcica-about-a-case
#20
Ghizlane El Mghari, Bouchra Rafiq, Nawal El Ansari
Epidermoid cyst (EC) or cholesteatoma is a benign tumor, often of congenital origin, occurring in the sub-arachnoidian spaces. Its treatment is based on surgery. We report the case of a 38 year-old patient presenting with progressive intracranial hypertension syndrome associated with anterior pituitary insufficiency signs of the corticotropic, thyrotropic, gonadotropic axis occurring 1 year before. Brain MRI showed a craniopharyngioma. Anatomopathologic evaluation of the specimen showed epidermoid cyst.
2017: Pan African Medical Journal
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