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V van Dee, B M van der Klis, M R van Dijk
OBJECTIVE: To gain insight in the career development of Utrecht medical school graduates. DESIGN: Retrospective cohort study. METHOD: In November 2015, we investigated the achieved academic title, occupation and position for 281 graduates who had started their medical education at University Medical Centre Utrecht (UMCU) in the academic year 2003-2004. Information was gathered from the BIG-register for medical professionals, through social media and Google, and if necessary through private messaging...
2017: Nederlands Tijdschrift Voor Geneeskunde
Peter J Van der Most, Leanne K Küpers, Harold Snieder, Ilja Nolte
Summary: The increasing popularity of epigenome-wide association studies (EWAS) has led to the establishment of several large international meta-analysis consortia. However, when using data originating from multiple sources, a thorough and centralized quality control is essential. To facilitate this, we developed the QCEWAS R package. QCEWAS enables automated quality control of results files of EWAS. QCEWAS produces cohort-specific statistics and graphs to interpret the quality of the results files, graphs comparing results of multiple cohorts, as well as cleaned input files ready for meta-analysis...
April 15, 2017: Bioinformatics
A M van Oers, H Groen, M A Q Mutsaerts, J M Burggraaff, W K H Kuchenbecker, D A M Perquin, C A M Koks, R van Golde, E M Kaaijk, J M Schierbeek, G J E Oosterhuis, F J Broekmans, N E A Vogel, J A Land, B W J Mol, A Hoek
STUDY QUESTION: Do age, ovulatory status, severity of obesity and body fat distribution affect the effectiveness of lifestyle intervention in obese infertile women? SUMMARY ANSWER: We did not identify a subgroup in which lifestyle intervention increased the healthy live birth rate however it did increase the natural conception rate in anovulatory obese infertile women. WHAT IS KNOWN ALREADY: Obese women are at increased risk of infertility and are less likely to conceive after infertility treatment...
December 2016: Human Reproduction
Antje-Christin Knopf, Kristin Stützer, Christian Richter, Antoni Rucinski, Joakim da Silva, Justin Phillips, Martijn Engelsman, Shinichi Shimizu, Rene Werner, Annika Jakobi, Orçun Göksel, Ye Zhang, Tuathan Oshea, Martin Fast, Rosalind Perrin, Christoph Bert, Ilaria Rinaldi, EriK Korevaar, Jamie McClelland
Since 2009, a 4D treatment planning workshop has taken place annually, gathering researchers working on the treatment of moving targets, mainly with scanned ion beams. Topics discussed during the workshops range from problems of time resolved imaging, the challenges of motion modelling, the implementation of 4D capabilities for treatment planning, up to different aspects related to 4D dosimetry and treatment verification. This report gives an overview on topics discussed at the 4D workshops in 2014 and 2015...
July 2016: Physica Medica: PM
Ahmad Vaez, Peter J van der Most, Bram P Prins, Harold Snieder, Edwin van den Heuvel, Behrooz Z Alizadeh, Ilja M Nolte
UNLABELLED: Genome-wide association study (GWAS) of a biomarker is complicated when the assay procedure of the biomarker is restricted by a Limit of Detection (LOD). Those observations falling outside the LOD cannot be simply discarded, but should be included into the analysis by applying an appropriate statistical method. However, the problem of LOD in GWAS analysis of such biomarkers is usually overlooked. 'lodGWAS' is a flexible, easy-to-use R package that provides a simple and elegant way for GWAS analysis of such biomarkers while simultaneously accommodating the problem of LOD by applying a parametric survival analysis method...
May 15, 2016: Bioinformatics
Theresia Rohde, K Kolpatzik, A F de Winter
Health literacy has been defined as the degree to which people are able to access, understand, appraise, and communicate information to make informed decisions about their health. It is therefore essential to be able to engage with the demands of different health contexts and to stay healthy. The topic of health literacy is thus receiving growing political and scientific attention and is becoming increasingly important in Germany too. Results of a survey on health literacy in Germany that were published by the AOK's scientific research institute, WidO, in 2014, stress the need for health literacy improvement...
September 2015: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
A C M Veloo, P E Elgersma, A J van Winkelhoff
Four clinical isolates of gram-positive strict anaerobic cocci were isolated from four different human mixed anaerobic infections. The taxonomical status of the four strains could not be established using standard identification techniques. The biochemical features of the strains were established and their taxonomic position was determined using 16S rRNA sequencing. The four strains form a homogeneous phenotypical and genotypical cluster. A new Anaerococcus species is proposed for these isolates: Anaerococcus degenerii sp...
June 2015: Anaerobe
Vera Verhage, Erik Noordik, Erik J Knorth, Sijmen A Reijneveld
TAKECARE is a prospective cohort study designed in The Netherlands to obtain evidence on the care chain for children and adolescents with psychosocial problems, and its long-term outcomes. Little is known about the content of care as offered and on whether the care is adequate. The cohort consists of children and adolescents entering care for psychosocial problems (care sample, n = 1382) and a random sample of the general population (community sample, n = 666). Children were eligible for participation if they were aged 4-18 years (inclusive) and had estimated IQs of 70 and over...
December 18, 2014: International Journal of Epidemiology
Salome Scholtens, Nynke Smidt, Morris A Swertz, Stephan J L Bakker, Aafje Dotinga, Judith M Vonk, Freerk van Dijk, Sander K R van Zon, Cisca Wijmenga, Bruce H R Wolffenbuttel, Ronald P Stolk
The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Participants visited one of the LifeLines research sites for a physical examination, including lung function, ECG and cognition tests, and completed extensive questionnaires...
August 2015: International Journal of Epidemiology
M R F Bosscher, B L van Leeuwen, H J Hoekstra
PURPOSE: Cancer patients can experience problems related to their disease or treatment. This study evaluated reasons for presentation at the emergency room (ER) and outcome of surgical oncology patients. METHODS: A retrospective chart review for all surgical oncology patients who presented at the ER of the UMCG for surgical consultation between October 1, 2012, and March 31, 2013. RESULTS: A total of 200 cancer patients visited the ER for surgical consultation: 53...
May 2015: Annals of Surgical Oncology
Monika A Chlebowicz, Ivana Mašlaňová, Lucie Kuntová, Hajo Grundmann, Roman Pantůček, Jiří Doškař, Jan Maarten van Dijl, Girbe Buist
The Staphylococcal Cassette Chromosome mec (SCCmec) confers methicillin resistance to Staphylococcus aureus. While SCCmec is generally regarded as a mobile genetic element, the precise mechanisms by which large SCCmec elements are exchanged between staphylococci have remained enigmatic. In the present studies, we observed that the clinical methicillin-resistant S. aureus (MRSA) isolate UMCG-M4 with the sequence type 398 contains four prophages belonging to the serological groups A, B and Fa. Previous studies have shown that certain serological group B bacteriophages of S...
July 2014: International Journal of Medical Microbiology: IJMM
Danique R M Vlaskamp, Oebele F Brouwer, Petra M C Callenbach
OBJECTIVES: To evaluate treatment of children with Prolonged Convulsive Seizures (PCS) at the University Medical Centre Groningen (UMCG). MATERIAL AND METHODS: PCS were identified from an UMCG database of children with epilepsy aged <18 years who had their first (a)febrile seizure between 2000 and 2010. PCS were included if they lasted ≥10 min and occurred between January 2000 and October 2012 in children aged >1 month. Order, timing, and location of treatment were analysed...
November 2014: European Journal of Paediatric Neurology: EJPN
Jerome R Lo-Ten-Foe, Bhanu Sinha, Kasper R Wilting, Yanka Veenstra-Kyuchukova, Prashant N Panday, Ron Hendrix
In 2012, the Dutch Working Party on Antibiotic Policy (SWAB) published a vision document to counteract the rise in antibiotic use and resistance. An Antibiotic Stewardship Programme (ASP) will be implemented by a multidisciplinary antibiotics team (A-team). In 2012 University Medical Centre Groningen (UMCG) in the Netherlands started an Antibiotic Stewardship Programme (ASP) pilot project at the trauma surgery ward. The focus is on providing bedside consultation for patients based on the day 2 bundle. Implementation of the ASP on the basis of a day 2 bundle resulted in an intervention percentage of 75%...
2014: Nederlands Tijdschrift Voor Geneeskunde
Peter J van der Most, Ahmad Vaez, Bram P Prins, M Loretto Munoz, Harold Snieder, Behrooz Z Alizadeh, Ilja M Nolte
QCGWAS is an R package that automates the quality control of genome-wide association result files. Its main purpose is to facilitate the quality control of a large number of such files before meta-analysis. Alternatively, it can be used by individual cohorts to check their own result files. QCGWAS is flexible and has a wide range of options, allowing rapid generation of high-quality input files for meta-analysis of genome-wide association studies. AVAILABILITY: CONTACT: i...
April 15, 2014: Bioinformatics
Monika A Chlebowicz, Thijs Bosch, Artur J Sabat, Jan P Arends, Hajo Grundmann, Jan Maarten van Dijl, Girbe Buist
Methicillin resistant S. aureus (MRSA) is a major threat for human health and well-being. In recent years, it has become clear that livestock is a potential reservoir for MRSA, most livestock-associated isolates belonging to the ST398 lineage. Importantly, ST398 strains were also reported as causative agents of severe invasive infections in humans with no evidence for livestock associations. Here we document the sequence of the J1 region of the type V (5C2&5) SCCmec element and its right chromosomal junction in the clinical PVL-positive ST398 MRSA isolate UMCG-M4...
December 2013: International Journal of Medical Microbiology: IJMM
Johanna Schönrock-Adema, Stuart Lubarsky, Colin Chalk, Yvonne Steinert, Janke Cohen-Schotanus
OBJECTIVES: Traditional student feedback questionnaires are imperfect course evaluation tools, largely because they generate low response rates and are susceptible to response bias. Preliminary research suggests that prediction-based methods of course evaluation - in which students estimate their peers' opinions rather than provide their own personal opinions - require significantly fewer respondents to achieve comparable results and are less subject to biasing influences. This international study seeks further support for the validity of these findings by investigating: (i) the performance of the prediction-based method, and (ii) its potential for bias...
May 2013: Medical Education
J B Terra, J M Meijer, M F Jonkman, G F H Diercks
BACKGROUND: Serration pattern analysis of direct immunofluorescence (DIF) allows the differentiation of epidermolysis bullosa acquisita from other subtypes of pemphigoid. In daily practice its use is limited due to lack of experience and unfamiliarity. OBJECTIVES: To test the learnability of DIF serrated-pattern recognition in groups with various a priori levels of competence. METHODS: An online nversusu-test ( was created, which contained 26 DIF images of the epidermal basement membrane zone, IgG stained and photographed with a magnification of × 40 and × 63...
July 2013: British Journal of Dermatology
Roelineke J Lunsing, Willem F H Pardoen, Mijna Hadders-Algra
BACKGROUND: The aim of this work was to investigate in a prospective study whether moderate hyperbilirubinemia in healthy term neonates is associated with an increase of minor neurological dysfunction (MND) and behavioral problems up to 18 mo. METHOD: We enrolled 43 healthy term infants with a bilirubin level ≥ 220 µmol/l (BILI group) at 72-96 h postnatally at the University Medical Center Groningen (UMCG), including eight referrals for hyperbilirubinemia. Seventy healthy term infants born at the UMCG with bilirubin level <220 µmol/l served as comparisons (COMP group)...
May 2013: Pediatric Research
N Vande Casteele, D J Buurman, M G G Sturkenboom, J H Kleibeuker, S Vermeire, T Rispens, D van der Kleij, A Gils, G Dijkstra
BACKGROUND: Formation of antibodies to infliximab (ATI) inversely correlates with functional drug levels and clinical outcome. Comparison of drug levels and anti-drug antibody monitoring is hampered by lack of standardisation. AIM: To determine the correlation between three different assays for measuring infliximab and ATI. METHODS: Serum samples and spiked controls (total 62) were evaluated in a blinded way in infliximab and ATI assays developed by Sanquin Amsterdam, Netherlands (A), Laboratory for Pharmaceutical Biology, KU Leuven, Belgium (B) and a commercially available kit from Biomedical Diagnostics (BMD), Paris, France (C) performed by the University Medical Center Groningen (UMCG), Netherlands...
October 2012: Alimentary Pharmacology & Therapeutics
Sophie Bolt, Rob Eisinga, Eric Venbrux, Jan B M Kuks, Peter O Gerrits
BACKGROUND: This study examines the relationship between motivation for body donation to science and personality characteristics using a body donor survey (N=759) conducted by the University Medical Centre Groningen (UMCG) in The Netherlands. The survey expands on anthropological studies that suggest an association between donor motivation and personality. METHODS: A structural equation model was used to investigate the relationship between personality and motivation for body donation...
March 2011: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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