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https://www.readbyqxmd.com/read/28043867/bont-ab-hybrid-maintains-similar-duration-of-paresis-as-bont-a-wild-type-in-murine-running-wheel-assay
#1
Anna Kutschenko, Marie-Christine Reinert, Nadja Krez, David Liebetanz, Andreas Rummel
The highly potent Botulinum neurotoxins (BoNT) are successful drugs to treat neuromuscular disorders. Efforts are being made to further reduce the injected BoNT dose and to lengthen the interval between treatments. Detailed knowledge of the BoNT structure-activity relationship (SAR) allows combining the best features of the different BoNT serotypes. Of all seven BoNT serotypes A-G, BoNT/A displays the highest potency despite low neuronal binding affinity, while BoNT/B exhibits much higher affinity. Recently, a new BoNT/AB hybrid (AABB) was constructed comprising the catalytic and translocation domain of BoNT/A and the 50kDa cell binding domain of BoNT/B...
December 30, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27958362/aggregation-and-gelation-of-aromatic-polyamides-with-parallel-and-anti-parallel-alignment-of-molecular-dipole-along-the-backbone
#2
Dan Zhu, Jing Shang, Xiaodong Ye, Jian Shen
The understanding of macromolecular structures and interactions is important but difficult, due to the facts that a macromolecules are of versatile conformations and aggregate states, which vary with environmental conditions and histories. In this work two polyamides with parallel or anti-parallel dipoles along the linear backbone, named as ABAB (parallel) and AABB (anti-parallel) have been studied. By using a combination of methods, the phase behaviors of the polymers during the aggregate and gelation, i.e...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870740/patient-blood-management-an-international-perspective
#3
Quentin Eichbaum, Michael Murphy, Yu Liu, Isaac Kajja, Ludhmila Abrahao Hajjar, Cees Th Smit Sibinga, Hua Shan
This article describes practices in patient blood management (PBM) in 4 countries on different continents that may provide insights for anesthesiologists and other physicians working in global settings. The article has its foundation in the proceedings of a session at the 2014 AABB annual meeting during which international experts from England, Uganda, China, and Brazil presented the programs and implementation strategies in PBM developed in their respective countries. To systematize the review and enhance the comparability between these countries on different continents, authors were requested to respond to the same set of 6 key questions with respect to their country's PBM program(s)...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27867152/transmitting-characters-of-individual-e-chromosomes-of-thinopyrum-elongatum-in-triticum-turgidum-background
#4
Li Haifeng, Liu Huiping, Dai Yi, Huang Shuai, Zhang Jun, Gao Yong, Chen Jianmin
The transmission patterns of Thinopyrum elongatum chromosomes in the background of Triticum turgidum were investigated through cytogenetic and molecular marker analysis based on the F2 and F3 plants derived from a cross between Triticum trititrigia (AABBEE) and T. turgidum L. ssp. durum (AABB). An additional objective was to develop durum-Th. elongatum E chromosome addition lines. Among 218 F2 plants, individuals with 2n=28 accounted for 41.7%, those with 2n=29 accounted for 18.3%, and the remaining 40.0% had 2n=31-42...
November 20, 2016: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/27847512/evidence-of-genomic-exchanges-between-homeologous-chromosomes-in-a-cross-of-peanut-with-newly-synthetized-allotetraploid-hybrids
#5
Joel R Nguepjop, Hodo-Abalo Tossim, Joseph M Bell, Jean-François Rami, Shivali Sharma, Brigitte Courtois, Nalini Mallikarjuna, Djibril Sane, Daniel Fonceka
Cultivated peanut and synthetics are allotetraploids (2n = 4x = 40) with two homeologous sets of chromosomes. Meiosis in allotetraploid peanut is generally thought to show diploid-like behavior. However, a recent study pointed out the occurrence of recombination between homeologous chromosomes, especially when synthetic allotetraploids are used, challenging the view of disomic inheritance in peanut. In this study, we investigated the meiotic behavior of allotetraploid peanut using 380 SSR markers and 90 F2 progeny derived from the cross between Arachis hypogaea cv Fleur 11 (AABB) and ISATGR278-18 (AAKK), a synthetic allotetraploid that harbors a K-genome that was reported to pair with the cultivated B-genome during meiosis...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27820837/estimating-the-burden-of-chagas-disease-in-the-united-states
#6
Jennifer Manne-Goehler, Chukwuemeka A Umeh, Susan P Montgomery, Veronika J Wirtz
BACKGROUND: In recent years, there has been growing awareness of the significant burden of Chagas disease in the United States (US). However, epidemiological data on both prevalence and access to care for this disease are limited. The objective of this study is to provide an updated national estimate of Chagas disease prevalence, the first state-level estimates of cases of T. cruzi infection in the US and to analyze these estimates in the context of data on confirmed cases of infection in the US blood supply...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27794527/the-challenges-of-daratumumab-in-transfusion-medicine
#7
REVIEW
Michael F Dizon
The field of transfusion medicine has evolved rapidly in recent years, but the central principle of transfusion is still simple, namely, the antigen-antibody interaction. Daratumumab (DARA), a monoclonal antibody (MoAb), was developed to treat relapsed/refractory multiple myeloma (RRMM). DARA works by targeting the CD38 portion of malignant cells; however, this drug attaches to the red blood cell (RBC) reagents used in blood banks, further complicating the antibody identification work-up. The AABB (formerly known as the American Association of Blood Banks) has issued a memorandum on how blood banks can effectively address panreactivity caused by DARA...
February 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/27739152/red-blood-cell-transfusion-2016-clinical-practice-guidelines-from-aabb
#8
Aaron A R Tobian, Nancy M Heddle, Theresa L Wiegmann, Jeffrey L Carson
No abstract text is available yet for this article.
October 2016: Transfusion
https://www.readbyqxmd.com/read/27732721/clinical-practice-guidelines-from-the-aabb-red-blood-cell-transfusion-thresholds-and-storage
#9
Jeffrey L Carson, Gordon Guyatt, Nancy M Heddle, Brenda J Grossman, Claudia S Cohn, Mark K Fung, Terry Gernsheimer, John B Holcomb, Lewis J Kaplan, Louis M Katz, Nikki Peterson, Glenn Ramsey, Sunil V Rao, John D Roback, Aryeh Shander, Aaron A R Tobian
Importance: More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain. Objective: To provide recommendations for the target hemoglobin level for RBC transfusion among hospitalized adult patients who are hemodynamically stable and the length of time RBCs should be stored prior to transfusion. Evidence Review: Reference librarians conducted a literature search for randomized clinical trials (RCTs) evaluating hemoglobin thresholds for RBC transfusion (1950-May 2016) and RBC storage duration (1948-May 2016) without language restrictions...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27732707/aabb-red-blood-cell-transfusion-guidelines-something-for-almost-everyone
#10
EDITORIAL
Mark H Yazer, Darrell J Triulzi
No abstract text is available yet for this article.
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27708169/the-need-for-education-in-molecular-immunohematology-a-survey-of-specialists-in-blood-banking
#11
Stephanie N Kinney, Jayanna Slayten, Dan A Waxman
BACKGROUND: Within transfusion medicine, the education of molecular technologies lacks standardization. OBJECTIVE: To address this problem, we surveyed specialist in blood bank technology (SBBT) programs, immunohematology reference laboratories, and SBBT graduates to define its current state. METHODS: An anonymous online survey (SurveyMonkey) was emailed to the 15 American Association of Blood Banks (AABB) SBBT programs, 59 AABB IRLs, and 82 SBBT graduates...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27703178/rapid-genomic-changes-in-allopolyploids-of-carassius-auratus-red-var-%C3%A2-%C3%A2-%C3%A3-%C3%A2-megalobrama-amblycephala-%C3%A2
#12
Qinbo Qin, Zhengfa Lai, Liu Cao, Qiong Xiao, YuDe Wang, Shaojun Liu
To better understand genomic changes in the early generations after polyploidisation, we examined the chromosomal consequences of genomic merger in allotetraploid hybrids (4 nF1) (AABB, 4n = 148) of Carassius auratus red var. (RCC) (AA, 2n = 100) (♀) × Megalobrama amblycephala (BSB) (BB, 2n = 48) (♂). Complete loss of the paternal 5S rDNA sequence and the expected number of maternal chromosomal loci were found in 4 nF1, suggesting directional genomic changes occurred in the first generations after polyploidisation...
October 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27642142/a-supplement-to-transfusion-abstract-presentations-from-the-aabb-annual-meeting-orlando-fl-october-22-25-2016
#13
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Transfusion
https://www.readbyqxmd.com/read/27611704/high-transferability-of-homoeolog-specific-markers-between-bread-wheat-and-newly-synthesized-hexaploid-wheat-lines
#14
Deying Zeng, Jiangtao Luo, Zenglin Li, Gang Chen, Lianquan Zhang, Shunzong Ning, Zhongwei Yuan, Youliang Zheng, Ming Hao, Dengcai Liu
Bread wheat (Triticum aestivum, 2n = 6x = 42, AABBDD) has a complex allohexaploid genome, which makes it difficult to differentiate between the homoeologous sequences and assign them to the chromosome A, B, or D subgenomes. The chromosome-based draft genome sequence of the 'Chinese Spring' common wheat cultivar enables the large-scale development of polymerase chain reaction (PCR)-based markers specific for homoeologs. Based on high-confidence 'Chinese Spring' genes with known functions, we developed 183 putative homoeolog-specific markers for chromosomes 4B and 7B...
2016: PloS One
https://www.readbyqxmd.com/read/27455830/comparison-of-double-rbc-collection-by-blood-cell-separators
#15
Pimpun Kitpoka, Sarawan Chanthet, Viroje Chongkolwatana, Ampaiwan Chuansumrit, Mongkol Kunakorn
BACKGROUND: The problem of red blood cell (RBC) shortage occurs because of the expanding demand for blood utilization and the dfficulties in donor recruitment and retention. Resources can be maximized by using current technology to collect two units of RBC from the same donor during a single collection session. OBJECTIVE: To evaluate the performance, collection efficiency (CE), production cost, and donor satisfactions of two commercially available blood cell separators (BCS) for double dose red cell (DDRC) collection...
January 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27391447/intraspecific-polymorphisms-of-cytogenetic-markers-mapped-on-chromosomes-of-triticum-polonicum-l
#16
Michał Kwiatek, Maciej Majka, Joanna Majka, Jolanta Belter, Elżbieta Suchowilska, Urszula Wachowska, Marian Wiwart, Halina Wiśniewska
Triticum genus encloses several tetraploid species that are used as genetic stocks for expanding the genetic variability of wheat (Triticum aestivum L.). Although the T. aestivum (2n = 6x = 42, AABBDD) and T. durum (2n = 4x = 28, AABB) karyotypes were well examined by chromosome staining, Giemsa C-banding and FISH markers, other tetraploids are still poorly characterized. Here, we established and compared the fluorescence in situ hybridization (FISH) patterns on chromosomes of 20 accessions of T. polonicum species using different repetitive sequences from BAC library of wheat 'Chinese Spring'...
2016: PloS One
https://www.readbyqxmd.com/read/27375543/discovery-of-a-recursive-principle-an-artificial-grammar-investigation-of-human-learning-of-a-counting-recursion-language
#17
Pyeong Whan Cho, Emily Szkudlarek, Whitney Tabor
Learning is typically understood as a process in which the behavior of an organism is progressively shaped until it closely approximates a target form. It is easy to comprehend how a motor skill or a vocabulary can be progressively learned-in each case, one can conceptualize a series of intermediate steps which lead to the formation of a proficient behavior. With grammar, it is more difficult to think in these terms. For example, center embedding recursive structures seem to involve a complex interplay between multiple symbolic rules which have to be in place simultaneously for the system to work at all, so it is not obvious how the mechanism could gradually come into being...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27301995/trends-in-united-states-blood-collection-and-transfusion-results-from-the-2013-aabb-blood-collection-utilization-and-patient-blood-management-survey
#18
Barbee Whitaker, Srijana Rajbhandary, Steven Kleinman, Andrea Harris, Naynesh Kamani
BACKGROUND: AABB surveyed AABB institutional members about their 2013 blood collection, transfusion, and patient blood management (PBM) programs. Results were compared with previous US national surveys. STUDY DESIGN AND METHODS: The 2013 AABB Blood Collection, Utilization, and Patient Blood Management Survey was distributed to AABB blood centers (79) and hospitals (1068). Statistical procedures were used to estimate blood collection and transfusion. RESULTS: Estimated whole blood (WB) and red blood cell (RBC) collections in 2013 totaled 13...
September 2016: Transfusion
https://www.readbyqxmd.com/read/27260107/transfusion-transmitted-babesia-microti
#19
REVIEW
Deanna C Fang, Jeffrey McCullough
Because testing of donors for Babesia microti has become available, it is important to determine the kinds of patients who should receive B microti-tested blood. We searched PubMed, AABB abstracts, and FDA Web site to identify all cases of transfusion-transmitted babesiosis (TTB). Cases were analyzed for underlying medical condition, age, presence of spleen, and reason for transfusion in relation to 5 classes of recipient outcome severity. Sixty-seven reports included 256 transfusion cases where donor tested positive for B microti, 165 of which resulted in TTB...
July 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/27176118/identification-of-peanut-arachis-hypogaea-chromosomes-using%C3%A2-a-fluorescence-in%C3%A2-situ-hybridization-system-reveals-multiple%C3%A2-hybridization-events-during-tetraploid-peanut-formation
#20
Laining Zhang, Xiaoyu Yang, Li Tian, Lei Chen, Weichang Yu
The cultivated peanut Arachis hypogaea (AABB) is thought to have originated from the hybridization of Arachis duranensis (AA) and Arachis ipaënsis (BB) followed by spontaneous chromosome doubling. In this study, we cloned and analyzed chromosome markers from cultivated peanut and its wild relatives. A fluorescence in situ hybridization (FISH)-based karyotyping cocktail was developed with which to study the karyotypes and chromosome evolution of peanut and its wild relatives. Karyotypes were constructed in cultivated peanut and its two putative progenitors using our FISH-based karyotyping system...
September 2016: New Phytologist
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