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https://www.readbyqxmd.com/read/29029366/directly-coupled-vs-spectator-linkers-on-diimine-pt-ii-acetylides-change-the-structure-keep-the-function
#1
Stuart Archer, Theo Keane, Milan Delor, Elizabeth Bevon, Alexander Auty, Dimitri Chekulaev, Igor Sazanovich, Michael Towrie, Antony Meijer, Julia Weinstein
A series of [Donor-Acceptor-Anchor] Platinum(II) bipy (bis)acetylides has been developed in order to systematically compare the effect of conjugated vs. electronically decoupled modes of attachment of protected anchoring groups on the photophysical properties of these light-harvesting units. This first example of "decoupled" phosphonate-diimine Pt(II) complexes presented here are compared and contrasted to their carboxylate analogs. Ultrafast TRIR and femtosecond transient absorption spectroscopies revealed that all complexes possess a charge transfer lowest excited state, with lifetimes between 2 and 14 ns...
October 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28989137/characteristic-of-malocclusion-among-saudi-special-need-group-children
#2
Thamer Alkhadra
INTRODUCTION: The present study analyzed the characteristics of malocclusions, occlusal traits among Special Health care Needs (SHCN) children with Down syndrome (DS) and autism disorder (AD) in Riyadh City, Kingdom of Saudi Arabia. MATERIALS AND METHODS: A total of 100 DS and 100 AD children from five rehabilitation centers in and around Riyadh, Kingdom of Saudi Arabia, were included in the study. Any children with history of ongoing medical treatment, extraction, or orthodontic treatment were excluded from the study...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28943355/boron-based-inhibitors-of-the-nlrp3-inflammasome
#3
Alex G Baldwin, Jack Rivers-Auty, Michael J D Daniels, Claire S White, Carl H Schwalbe, Tom Schilling, Halah Hammadi, Panichakorn Jaiyong, Nicholas G Spencer, Hazel England, Nadia M Luheshi, Manikandan Kadirvel, Catherine B Lawrence, Nancy J Rothwell, Michael K Harte, Richard A Bryce, Stuart M Allan, Claudia Eder, Sally Freeman, David Brough
NLRP3 is a receptor important for host responses to infection, yet is also known to contribute to devastating diseases such as Alzheimer's disease, diabetes, atherosclerosis, and others, making inhibitors for NLRP3 sought after. One of the inhibitors currently in use is 2-aminoethoxy diphenylborinate (2APB). Unfortunately, in addition to inhibiting NLRP3, 2APB also displays non-selective effects on cellular Ca(2+) homeostasis. Here, we use 2APB as a chemical scaffold to build a series of inhibitors, the NBC series, which inhibit the NLRP3 inflammasome in vitro and in vivo without affecting Ca(2+) homeostasis...
September 1, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28903877/exploring-the-role-of-small-scale-livestock-keepers-for-national-biosecurity-the-pig-case
#4
Carla Correia-Gomes, Madeleine K Henry, Harriet K Auty, George J Gunn
Small-scale keepers are less likely to engage with production organisations and may therefore be less aware of legislation, rules and biosecurity practices which are implemented in the livestock sector. Their role in the transmission of endemic and exotic diseases is not well studied, but is believed to be important. The authors use small-scale pig keepers in Scotland as an example of how important small-scale livestock keepers might be for national biosecurity. In Scotland more than two thirds of pig producers report that they keep less than 10 pigs, meaning that biosecurity practices and pig health status on a substantial number of holdings are largely unknown; it is considered important to fill this knowledge gap...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28812006/main-pulmonary-artery-trifurcation-in-association-with-persistent-right-common-pulmonary-vein-a-piece-of-embryological-puzzle
#5
Venkatraman Bhat, Karthik Gadabanahalli, Onkar Auti
No abstract text is available yet for this article.
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28761045/salmonella-typhimurium-induced-il-1-release-from-primary-human-monocytes-requires-nlrp3-and-can-occur-in-the-absence-of-pyroptosis
#6
Catherine E Diamond, Keith Weng Kit Leong, Maurizio Vacca, Jack Rivers-Auty, David Brough, Alessandra Mortellaro
Large molecular complexes known as inflammasomes regulate the release of IL-1β from immune cells in response to infection and injury. Salmonella typhimurium infection is reported to activate NLRP3 and NLRC4 inflammasomes which are subsequently involved in pyroptosis of the cell and pathogen clearance. However, the response to S. typhimurium in primary human monocytes has not been studied in detail. The aim of this study was to investigate the effect of S. typhimurium on inflammasomes in primary human monocytes...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710167/detecting-and-managing-new-animal-health-threats-how-vulnerable-are-we
#7
Carla Correia-Gomes, Harriet K Auty
No abstract text is available yet for this article.
July 15, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28690057/effects-of-depleting-ionic-strength-on-31-p-nuclear-magnetic-resonance-spectra-of-micellar-casein-during-membrane-separation-and-diafiltration-of-skim-milk
#8
Mattia Boiani, Padraig McLoughlin, Mark A E Auty, Richard J FitzGerald, Phil M Kelly
Membrane separation processes used in the concentration and isolation of micellar casein-based milk proteins from skim milk rely on extensive permeation of its soluble serum constituents, especially lactose and minerals. Whereas extensive literature exists on how these processes influence the gross composition of milk proteins, we have little understanding of the effects of such ionic depletion on the core structural unit of micellar casein [i.e., the casein phosphate nanocluster (CPN)]. The (31)P nuclear magnetic resonance (NMR) is an analytical technique that is capable of identifying soluble and organic forms of phosphate in milk...
September 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28493417/retroesophageal-course-of-left-brachiocephalic-vein-the-garland-vein
#9
Onkar B Auti, Pradeep K Kaushik, Prakash Ramachandra, Vimal Raj
No abstract text is available yet for this article.
May 10, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28451090/a-rare-complication-of-pulmonary-tuberculosis-pulmonary-venous-thrombosis-with-atrial-extension
#10
Onkar Balasaheb Auti, Ranganath R, Murali Mohan Bv, Vimal Raj
Pulmonary tuberculosis (TB) is serious public health problem in India and worldwide. The mortality rate in pulmonary TB is high in those with advanced disease and in presence of complications. It presents with wide variety of complications of which haematological complications are rare. Many cases were reported pulmonary TB associated with deep venous thrombosis, hepatic and portal venous thrombosis, central retinal venous thrombosis and sagittal sinus thrombosis in TB meningitis. We report a rare case of pulmonary TB with pulmonary venous thrombosis and atrial extension...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28399478/quantifying-environmental-and-personal-risks-of-nanotechnology-for-industry
#11
REVIEW
Andrew R Auty
Regulators continue to pursue a comprehensive, generalisable, transparent, reliable, accurate and universally commended injury risk assessment methodology for nanomaterials. After a decade of intensive effort, it emerges that many of the prototype risk metrics are uninformative. This situation has given rise to practical, if non-validated, guidance in the form of control banding recommendations. While informative these are often logically deficient and take no account of risk context as captured in the concept of risk appetite...
April 8, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28225040/vulnerability-of-the-british-swine-industry-to-classical-swine-fever
#12
Thibaud Porphyre, Carla Correia-Gomes, Margo E Chase-Topping, Kokouvi Gamado, Harriet K Auty, Ian Hutchinson, Aaron Reeves, George J Gunn, Mark E J Woolhouse
Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during the 2000 epidemic of CSF in Great Britain (GB), a spatially explicit, premises-based model was developed to explore the risk of CSF spread in GB. We found that large outbreaks of CSF would be rare and generated from a limited number of areas in GB...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28009077/inflammasomes-as-therapeutic-targets-for-alzheimer-s-disease
#13
Claire S White, Catherine B Lawrence, David Brough, Jack Rivers-Auty
Alzheimer's disease is the most common form of progressive dementia, typified initially by short term memory deficits which develop into a dramatic global cognitive decline. The classical hall marks of Alzheimer's disease include the accumulation of amyloid oligomers and fibrils, and the intracellular formation of neurofibrillary tangles of hyperphosphorylated tau. It is now clear that inflammation also plays a central role in the pathogenesis of the disease through a number of neurotoxic mechanisms. Microglia are the key immune regulators of the CNS which detect amyloidopathy through cell surface and cytosolic pattern recognition receptors (PRRs) and respond by initiating inflammation through the secretion of cytokines such as interleukin-1β (IL-1β)...
March 2017: Brain Pathology
https://www.readbyqxmd.com/read/27958339/assessing-the-potential-for-bluetongue-virus-8-to-spread-and-vaccination-strategies-in-scotland
#14
Paul R Bessell, Kate R Searle, Harriet K Auty, Ian G Handel, Bethan V Purse, B Mark de C Bronsvoort
Europe has seen frequent outbreaks of Bluetongue (BT) disease since 2006, including an outbreak of BT virus serotype 8 in central France during 2015 that has continued to spread in Europe during 2016. Thus, assessing the potential for BTv-8 spread and determining the optimal deployment of vaccination is critical for contingency planning. We developed a spatially explicit mathematical model of BTv-8 spread in Scotland and explored the sensitivity of transmission to key disease spread parameters for which detailed empirical data is lacking...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802235/mitochondrial-abnormalities-and-synaptic-loss-underlie-memory-deficits-seen-in-mouse-models-of-obesity-and-alzheimer-s-disease
#15
Isaura V A Martins, Jack Rivers-Auty, Stuart M Allan, Catherine B Lawrence
Obesity is associated with impaired memory in humans, and obesity induced by high-fat diets leads to cognitive deficits in rodents and in mouse models of Alzheimer's disease (AD). However, it remains unclear how high-fat diets contribute to memory impairment. Therefore, we tested the effect of a high-fat diet on memory in male and female control non-transgenic (Non-Tg) and triple-transgenic AD (3xTgAD) mice and determined if a high-fat diet caused similar ultrastructural abnormalities to those observed in AD...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27706167/quantifying-heterogeneity-in-host-vector-contact-tsetse-glossina-swynnertoni-and-g-pallidipes-host-choice-in-serengeti-national-park-tanzania
#16
Harriet Auty, Sarah Cleaveland, Imna Malele, Joseph Masoy, Tiziana Lembo, Paul Bessell, Stephen Torr, Kim Picozzi, Susan C Welburn
BACKGROUND: Identifying hosts of blood-feeding insect vectors is crucial in understanding their role in disease transmission. Rhodesian human African trypanosomiasis (rHAT), also known as acute sleeping sickness is caused by Trypanosoma brucei rhodesiense and transmitted by tsetse flies. The disease is commonly associated with wilderness areas of east and southern Africa. Such areas hold a diverse range of species which form communities of hosts for disease maintenance. The relative importance of different wildlife hosts remains unclear...
2016: PloS One
https://www.readbyqxmd.com/read/27648214/give-it-a-tug-and-feel-it-grow-extending-body-perception-through-the-universal-nature-of-illusory-finger-stretching
#17
Roger Newport, Kelly Auty, Mark Carey, Katie Greenfield, Ellen M Howard, Natasha Ratcliffe, Hayley Thair, Kristy Themelis
If British teenage boy asks you to pull his finger, it is usually an indication that he simultaneously wishes to break wind. If you were to tell him that you could pull his finger and stretch it to twice its length, you might expect a similarly irreverent response yet when we pulled the fingers of nearly 600 children and adolescents, 93% reported the illusion of stretching. Grossly distorted body representations need not be the preserve of clinical disorders and can reliably be induced in healthy participants across all ages...
October 2015: I-Perception
https://www.readbyqxmd.com/read/27509875/fenamate-nsaids-inhibit-the-nlrp3-inflammasome-and-protect-against-alzheimer-s-disease-in-rodent-models
#18
Michael J D Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G Spencer, William Watremez, Victoria Fasolino, Sophie J Booth, Claire S White, Alex G Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M Allan, Pawel Paszek, James Galea, Michael K Harte, Claudia Eder, Catherine B Lawrence, David Brough
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many inflammatory diseases. Here we show that several clinically approved and widely used NSAIDs of the fenamate class are effective and selective inhibitors of the NLRP3 inflammasome via inhibition of the volume-regulated anion channel in macrophages, independently of COX enzymes...
August 11, 2016: Nature Communications
https://www.readbyqxmd.com/read/27501063/-is-voice-a-marker-for-autism-spectrum-disorder-a-systematic-review-and-meta-analysis
#19
REVIEW
Riccardo Fusaroli, Anna Lambrechts, Dan Bang, Dermot M Bowler, Sebastian B Gaigg
Individuals with Autism Spectrum Disorder (ASD) tend to show distinctive, atypical acoustic patterns of speech. These behaviors affect social interactions and social development and could represent a non-invasive marker for ASD. We systematically reviewed the literature quantifying acoustic patterns in ASD. Search terms were: (prosody OR intonation OR inflection OR intensity OR pitch OR fundamental frequency OR speech rate OR voice quality OR acoustic) AND (autis* OR Asperger). Results were filtered to include only: empirical studies quantifying acoustic features of vocal production in ASD, with a sample size >2, and the inclusion of a neurotypical comparison group and/or correlations between acoustic measures and severity of clinical features...
March 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27476512/effect-of-phytosterols-on-the-crystallization-behavior-of-oil-in-water-milk-fat-emulsions
#20
Lisa M Zychowski, Amy Logan, Mary Ann Augustin, Alan L Kelly, Alexandru Zabara, James A O'Mahony, Charlotte E Conn, Mark A E Auty
Milk has been used commercially as a carrier for phytosterols, but there is limited knowledge on the effect of added plant sterols on the properties of the system. In this study, phytosterols dispersed in milk fat at a level of 0.3 or 0.6% were homogenized with an aqueous dispersion of whey protein isolate (WPI). The particle size, morphology, ζ-potential, and stability of the emulsions were investigated. Emulsion crystallization properties were examined through the use of differential scanning calorimetry (DSC) and Synchrotron X-ray scattering at both small and wide angles...
August 31, 2016: Journal of Agricultural and Food Chemistry
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