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https://www.readbyqxmd.com/read/29379235/levoatrial-cardinal-vein-with-normal-left-ventricle-a-forgotten-cause-of-pulmonary-arterial-hypertension
#1
Onkar B Auti, Varun Shetty, Vinay Belaval, Vimal Raj
Levoatrial cardinal vein (LACV) is anomalous connection between left atrium or pulmonary veins and systemic veins such as innominate vein or superior vena cava. This persistence of splanchnic circulation occurs when there is left-sided obstructive cardiac lesions such as hypoplastic left heart or mitral atresia. In this report we present three cases of LACV with well-developed left heart, without any obstructive lesions. All our cases presented with pulmonary arterial hypertension (PAH) and had associated intracardiac shunt such as ventricular/atrial septal defect and supracardiac partial anomalous pulmonary venous connection...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29379234/cardiac-magnetic-resonance-techniques-our-experience-on-wide-bore-3-tesla-magnetic-resonance-system
#2
Onkar B Auti, Kalashree Bandekar, Nikhil Kamat, Vimal Raj
Cardiovascular magnetic resonance (CMR) has become a widely adapted imaging modality in the diagnosis and management of patients with cardiovascular diseases. It provides unparalleled data of cardiac function and myocardial morphology. Majority of CMR imaging is currently being performed on 1.5 Tesla (T) MR systems. Over the last many years, the cardiac imaging protocols have been standardized and optimized in the 1.5T systems. 3T MR systems are now being used more and more in small and large institutions in our country due to their proven advantages in the field of neuro, body, and musculoskeletal imaging...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29337535/anion-mediated-photophysical-behavior-in-a-c60-fullerene-3-rotaxane-shuttle
#3
Timothy A Barendt, Ilija Rašović, Maria A Lebedeva, George A Farrow, Alexander Auty, Dimitri Chekulaev, Igor V Sazanovich, Julia A Weinstein, Kyriakos Porfyrakis, Paul D Beer
By addressing the challenge of controlling molecular motion, mechanically interlocked molecular machines are primed for a variety of applications in the field of nanotechnology. Specifically, the designed manipulation of communication pathways between electron donor and acceptor moieties that are strategically integrated into dynamic photoactive rotaxanes and catenanes may lead to efficient artificial photosynthetic devices. In this pursuit, a novel [3]rotaxane molecular shuttle consisting of a four station bis-naphthalene diimide (NDI) and central C60 fullerene bis-triazolium axle component and two mechanically bonded ferrocenyl functionalized -isophthalamide anion binding site-containing macrocycles is constructed using an anion template synthetic methodology...
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29326780/cardiac-magnetic-resonance-of-myocardial-involvement-in-leptospirosis
#4
Onkar B Auti, Kanav Kansal, K V Shrikanth, Vimal Raj
Leptospirosis is a zoonotic infection caused by the Leptospira interrogans. Although it is endemic in tropical countries, global incidence has increased in several temperate and developed regions. Here, we present a cardiac magnetic resonance (CMR) and multidetector computer tomography (MDCT) chest features of active systemic leptospiral infection in a 19-year-old male. The MDCT appearances of lungs and CMR appearances of myocardium in icteric leptospirosis are described. Early diagnosis and prompt treatment is important to manage the cardiothoracic complications...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29230402/animal-health-surveillance-in-scotland-in-2030-using-scenario-planning-to-develop-strategies-in-the-context-of-brexit
#5
Lisa A Boden, Harriet Auty, Aaron Reeves, Gustaf Rydevik, Paul Bessell, Iain J McKendrick
Animal health surveillance is necessary to protect human and animal health, rural economies, and the environment from the consequences of large-scale disease outbreaks. In Scotland, since the Kinnaird review in 2011, efforts have been made to engage with stakeholders to ensure that the strategic goals of surveillance are better aligned with the needs of the end-users and other beneficiaries. The aims of this study were to engage with Scottish surveillance stakeholders and multidisciplinary experts to inform the future long-term strategy for animal health surveillance in Scotland...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29068048/possibilities-for-developing-texture-modified-beef-steaks-suitable-for-older-consumers-using-fruit-derived-proteolytic-enzymes
#6
Cristina Botinestean, Carolina Gomez, Yingqun Nian, Mark A E Auty, Joseph P Kerry, Ruth M Hamill
Meat intakes in the older population are commonly reduced because the relatively tough texture of meat can impair mastication. Fruit-derived proteolytic enzymes have been reported to have beneficial effects on tenderness, by causing significant degradation of myofibrillar proteins and collagen. Three treatments including: papain, bromelain and a 50:50 mixture of papain/bromelain, alongside one control were applied to beef M. semitendinosus steaks. Effects on Warner - Bratzler shear force, texture parameters, color, and cook loss were determined...
October 25, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/29029366/directly-coupled-vs-spectator-linkers-on-diimine-pt-ii-acetylides-change-the-structure-keep-the-function
#7
Stuart Archer, Theo Keane, Milan Delor, Elizabeth Bevon, Alexander Auty, Dimitri Chekulaev, Igor Sazanovich, Michael Towrie, Antony Meijer, Julia Weinstein
A series of [Donor-Acceptor-Anchor] Platinum(II) bipy (bis)acetylides has been developed in order to systematically compare the effect of conjugated vs. electronically decoupled modes of attachment of protected anchoring groups on the photophysical properties of these light-harvesting units. This first example of "decoupled" phosphonate-diimine Pt(II) complexes presented here are compared and contrasted to their carboxylate analogs. Ultrafast TRIR and femtosecond transient absorption spectroscopies revealed that all complexes possess a charge transfer lowest excited state, with lifetimes between 2 and 14 ns...
October 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28989137/characteristic-of-malocclusion-among-saudi-special-need-group-children
#8
Thamer Alkhadra
INTRODUCTION: The present study analyzed the characteristics of malocclusions, occlusal traits among Special Health care Needs (SHCN) children with Down syndrome (DS) and autism disorder (AD) in Riyadh City, Kingdom of Saudi Arabia. MATERIALS AND METHODS: A total of 100 DS and 100 AD children from five rehabilitation centers in and around Riyadh, Kingdom of Saudi Arabia, were included in the study. Any children with history of ongoing medical treatment, extraction, or orthodontic treatment were excluded from the study...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28943355/boron-based-inhibitors-of-the-nlrp3-inflammasome
#9
Alex G Baldwin, Jack Rivers-Auty, Michael J D Daniels, Claire S White, Carl H Schwalbe, Tom Schilling, Halah Hammadi, Panichakorn Jaiyong, Nicholas G Spencer, Hazel England, Nadia M Luheshi, Manikandan Kadirvel, Catherine B Lawrence, Nancy J Rothwell, Michael K Harte, Richard A Bryce, Stuart M Allan, Claudia Eder, Sally Freeman, David Brough
NLRP3 is a receptor important for host responses to infection, yet is also known to contribute to devastating diseases such as Alzheimer's disease, diabetes, atherosclerosis, and others, making inhibitors for NLRP3 sought after. One of the inhibitors currently in use is 2-aminoethoxy diphenylborinate (2APB). Unfortunately, in addition to inhibiting NLRP3, 2APB also displays non-selective effects on cellular Ca(2+) homeostasis. Here, we use 2APB as a chemical scaffold to build a series of inhibitors, the NBC series, which inhibit the NLRP3 inflammasome in vitro and in vivo without affecting Ca(2+) homeostasis...
November 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28903877/exploring-the-role-of-small-scale-livestock-keepers-for-national-biosecurity-the-pig-case
#10
Carla Correia-Gomes, Madeleine K Henry, Harriet K Auty, George J Gunn
Small-scale keepers are less likely to engage with production organisations and may therefore be less aware of legislation, rules and biosecurity practices which are implemented in the livestock sector. Their role in the transmission of endemic and exotic diseases is not well studied, but is believed to be important. The authors use small-scale pig keepers in Scotland as an example of how important small-scale livestock keepers might be for national biosecurity. In Scotland more than two thirds of pig producers report that they keep less than 10 pigs, meaning that biosecurity practices and pig health status on a substantial number of holdings are largely unknown; it is considered important to fill this knowledge gap...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28812006/main-pulmonary-artery-trifurcation-in-association-with-persistent-right-common-pulmonary-vein-a-piece-of-embryological-puzzle
#11
Venkatraman Bhat, Karthik Gadabanahalli, Onkar Auti
No abstract text is available yet for this article.
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28761045/salmonella-typhimurium-induced-il-1-release-from-primary-human-monocytes-requires-nlrp3-and-can-occur-in-the-absence-of-pyroptosis
#12
Catherine E Diamond, Keith Weng Kit Leong, Maurizio Vacca, Jack Rivers-Auty, David Brough, Alessandra Mortellaro
Large molecular complexes known as inflammasomes regulate the release of IL-1β from immune cells in response to infection and injury. Salmonella typhimurium infection is reported to activate NLRP3 and NLRC4 inflammasomes which are subsequently involved in pyroptosis of the cell and pathogen clearance. However, the response to S. typhimurium in primary human monocytes has not been studied in detail. The aim of this study was to investigate the effect of S. typhimurium on inflammasomes in primary human monocytes...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710167/detecting-and-managing-new-animal-health-threats-how-vulnerable-are-we
#13
Carla Correia-Gomes, Harriet K Auty
No abstract text is available yet for this article.
July 15, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28690057/effects-of-depleting-ionic-strength-on-31-p-nuclear-magnetic-resonance-spectra-of-micellar-casein-during-membrane-separation-and-diafiltration-of-skim-milk
#14
Mattia Boiani, Padraig McLoughlin, Mark A E Auty, Richard J FitzGerald, Phil M Kelly
Membrane separation processes used in the concentration and isolation of micellar casein-based milk proteins from skim milk rely on extensive permeation of its soluble serum constituents, especially lactose and minerals. Whereas extensive literature exists on how these processes influence the gross composition of milk proteins, we have little understanding of the effects of such ionic depletion on the core structural unit of micellar casein [i.e., the casein phosphate nanocluster (CPN)]. The (31)P nuclear magnetic resonance (NMR) is an analytical technique that is capable of identifying soluble and organic forms of phosphate in milk...
September 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28493417/retroesophageal-course-of-left-brachiocephalic-vein-the-garland-vein
#15
Onkar B Auti, Pradeep K Kaushik, Prakash Ramachandra, Vimal Raj
No abstract text is available yet for this article.
May 10, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28451090/a-rare-complication-of-pulmonary-tuberculosis-pulmonary-venous-thrombosis-with-atrial-extension
#16
Onkar Balasaheb Auti, Ranganath R, Murali Mohan Bv, Vimal Raj
Pulmonary tuberculosis (TB) is serious public health problem in India and worldwide. The mortality rate in pulmonary TB is high in those with advanced disease and in presence of complications. It presents with wide variety of complications of which haematological complications are rare. Many cases were reported pulmonary TB associated with deep venous thrombosis, hepatic and portal venous thrombosis, central retinal venous thrombosis and sagittal sinus thrombosis in TB meningitis. We report a rare case of pulmonary TB with pulmonary venous thrombosis and atrial extension...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28399478/quantifying-environmental-and-personal-risks-of-nanotechnology-for-industry
#17
REVIEW
Andrew R Auty
Regulators continue to pursue a comprehensive, generalisable, transparent, reliable, accurate and universally commended injury risk assessment methodology for nanomaterials. After a decade of intensive effort, it emerges that many of the prototype risk metrics are uninformative. This situation has given rise to practical, if non-validated, guidance in the form of control banding recommendations. While informative these are often logically deficient and take no account of risk context as captured in the concept of risk appetite...
April 8, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28225040/vulnerability-of-the-british-swine-industry-to-classical-swine-fever
#18
Thibaud Porphyre, Carla Correia-Gomes, Margo E Chase-Topping, Kokouvi Gamado, Harriet K Auty, Ian Hutchinson, Aaron Reeves, George J Gunn, Mark E J Woolhouse
Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during the 2000 epidemic of CSF in Great Britain (GB), a spatially explicit, premises-based model was developed to explore the risk of CSF spread in GB. We found that large outbreaks of CSF would be rare and generated from a limited number of areas in GB...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28009077/inflammasomes-as-therapeutic-targets-for-alzheimer-s-disease
#19
Claire S White, Catherine B Lawrence, David Brough, Jack Rivers-Auty
Alzheimer's disease is the most common form of progressive dementia, typified initially by short term memory deficits which develop into a dramatic global cognitive decline. The classical hall marks of Alzheimer's disease include the accumulation of amyloid oligomers and fibrils, and the intracellular formation of neurofibrillary tangles of hyperphosphorylated tau. It is now clear that inflammation also plays a central role in the pathogenesis of the disease through a number of neurotoxic mechanisms. Microglia are the key immune regulators of the CNS which detect amyloidopathy through cell surface and cytosolic pattern recognition receptors (PRRs) and respond by initiating inflammation through the secretion of cytokines such as interleukin-1β (IL-1β)...
March 2017: Brain Pathology
https://www.readbyqxmd.com/read/27958339/assessing-the-potential-for-bluetongue-virus-8-to-spread-and-vaccination-strategies-in-scotland
#20
Paul R Bessell, Kate R Searle, Harriet K Auty, Ian G Handel, Bethan V Purse, B Mark de C Bronsvoort
Europe has seen frequent outbreaks of Bluetongue (BT) disease since 2006, including an outbreak of BT virus serotype 8 in central France during 2015 that has continued to spread in Europe during 2016. Thus, assessing the potential for BTv-8 spread and determining the optimal deployment of vaccination is critical for contingency planning. We developed a spatially explicit mathematical model of BTv-8 spread in Scotland and explored the sensitivity of transmission to key disease spread parameters for which detailed empirical data is lacking...
December 13, 2016: Scientific Reports
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