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https://www.readbyqxmd.com/read/29594161/assessing-the-economic-impact-of-vaccine-availability-when-controlling-foot-and-mouth-disease-outbreaks
#1
Thibaud Porphyre, Karl M Rich, Harriet K Auty
Predictive models have been used extensively to assess the likely effectiveness of vaccination policies as part of control measures in the event of a foot and mouth disease (FMD) outbreak. However, the availability of vaccine stocks and the impact of vaccine availability on disease control strategies represent a key uncertainty when assessing potential control strategies. Using an epidemiological, spatially explicit, simulation model in combination with a direct cost calculator, we assessed how vaccine availability constraints may affect the economic benefit of a "vaccination-to-live" strategy during a FMD outbreak in Scotland, when implemented alongside culling of infected premises and dangerous contacts...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29559685/redefining-the-ancestral-origins-of-the-interleukin-1-superfamily
#2
Jack Rivers-Auty, Michael J D Daniels, Isaac Colliver, David L Robertson, David Brough
The interleukin-1 (IL-1) receptor and ligand families are components of the immune system. Knowledge of their evolutionary history is essential to understand their function. Using chromosomal anatomy and sequence similarity, we show that IL-1 receptor family members are related and nine members are likely formed from duplication and modification of a proto-IL-1R1 receptor. The IL-1 ligands have a different evolutionary history. The first proto-IL-1β gene coincided with proto-IL-1R1 and duplication events resulted in the majority of IL-1 ligand family members...
March 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29552940/the-reliability-and-validity-of-the-adaptive-functioning-assessment-tool-in-uk-custodial-settings
#3
Gareth E Ross, Kerensa Hocken, Jonathan M Auty
Adaptive functioning (AF) has been overlooked in the assessment of intellectual disability within the UK Prison Service, primarily because there are no reliable and valid measures of AF suitable for use with prison populations. This position is incompatible with the obligation of Her Majesty's Prison and Probation Service to provide specialist interventions for individuals with intellectual disabilities. This study assessed the psychometric properties of the Adaptive Functioning Assessment Tool (AFAT), a new measure of AF developed for use in prisons...
January 1, 2018: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/29379235/levoatrial-cardinal-vein-with-normal-left-ventricle-a-forgotten-cause-of-pulmonary-arterial-hypertension
#4
Onkar B Auti, Varun Shetty, Vinay Belaval, Vimal Raj
Levoatrial cardinal vein (LACV) is anomalous connection between left atrium or pulmonary veins and systemic veins such as innominate vein or superior vena cava. This persistence of splanchnic circulation occurs when there is left-sided obstructive cardiac lesions such as hypoplastic left heart or mitral atresia. In this report we present three cases of LACV with well-developed left heart, without any obstructive lesions. All our cases presented with pulmonary arterial hypertension (PAH) and had associated intracardiac shunt such as ventricular/atrial septal defect and supracardiac partial anomalous pulmonary venous connection...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29379234/cardiac-magnetic-resonance-techniques-our-experience-on-wide-bore-3-tesla-magnetic-resonance-system
#5
Onkar B Auti, Kalashree Bandekar, Nikhil Kamat, Vimal Raj
Cardiovascular magnetic resonance (CMR) has become a widely adapted imaging modality in the diagnosis and management of patients with cardiovascular diseases. It provides unparalleled data of cardiac function and myocardial morphology. Majority of CMR imaging is currently being performed on 1.5 Tesla (T) MR systems. Over the last many years, the cardiac imaging protocols have been standardized and optimized in the 1.5T systems. 3T MR systems are now being used more and more in small and large institutions in our country due to their proven advantages in the field of neuro, body, and musculoskeletal imaging...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29337535/anion-mediated-photophysical-behavior-in-a-c-60-fullerene-3-rotaxane-shuttle
#6
Timothy A Barendt, Ilija Rašović, Maria A Lebedeva, George A Farrow, Alexander Auty, Dimitri Chekulaev, Igor V Sazanovich, Julia A Weinstein, Kyriakos Porfyrakis, Paul D Beer
By addressing the challenge of controlling molecular motion, mechanically interlocked molecular machines are primed for a variety of applications in the field of nanotechnology. Specifically, the designed manipulation of communication pathways between electron donor and acceptor moieties that are strategically integrated into dynamic photoactive rotaxanes and catenanes may lead to efficient artificial photosynthetic devices. In this pursuit, a novel [3]rotaxane molecular shuttle consisting of a four-station bis-naphthalene diimide (NDI) and central C60 fullerene bis-triazolium axle component and two mechanically bonded ferrocenyl-functionalized isophthalamide anion binding site-containing macrocycles is constructed using an anion template synthetic methodology...
February 7, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29326780/cardiac-magnetic-resonance-of-myocardial-involvement-in-leptospirosis
#7
Onkar B Auti, Kanav Kansal, K V Shrikanth, Vimal Raj
Leptospirosis is a zoonotic infection caused by the Leptospira interrogans . Although it is endemic in tropical countries, global incidence has increased in several temperate and developed regions. Here, we present a cardiac magnetic resonance (CMR) and multidetector computer tomography (MDCT) chest features of active systemic leptospiral infection in a 19-year-old male. The MDCT appearances of lungs and CMR appearances of myocardium in icteric leptospirosis are described. Early diagnosis and prompt treatment is important to manage the cardiothoracic complications...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29230402/animal-health-surveillance-in-scotland-in-2030-using-scenario-planning-to-develop-strategies-in-the-context-of-brexit
#8
Lisa A Boden, Harriet Auty, Aaron Reeves, Gustaf Rydevik, Paul Bessell, Iain J McKendrick
Animal health surveillance is necessary to protect human and animal health, rural economies, and the environment from the consequences of large-scale disease outbreaks. In Scotland, since the Kinnaird review in 2011, efforts have been made to engage with stakeholders to ensure that the strategic goals of surveillance are better aligned with the needs of the end-users and other beneficiaries. The aims of this study were to engage with Scottish surveillance stakeholders and multidisciplinary experts to inform the future long-term strategy for animal health surveillance in Scotland...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29068048/possibilities-for-developing-texture-modified-beef-steaks-suitable-for-older-consumers-using-fruit-derived-proteolytic-enzymes
#9
Cristina Botinestean, Carolina Gomez, Yingqun Nian, Mark A E Auty, Joseph P Kerry, Ruth M Hamill
Meat intakes in the older population are commonly reduced because the relatively tough texture of meat can impair mastication. Fruit-derived proteolytic enzymes have been reported to have beneficial effects on tenderness, by causing significant degradation of myofibrillar proteins and collagen. Three treatments including: papain, bromelain and a 50:50 mixture of papain/bromelain, alongside one control were applied to beef M. semitendinosus steaks. Effects on Warner - Bratzler shear force, texture parameters, color, and cook loss were determined...
October 25, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/29029366/directly-coupled-versus-spectator-linkers-on-diimine-pt-ii-acetylides-change-the-structure-keep-the-function
#10
Stuart A Archer, Theo Keane, Milan Delor, Elizabeth Bevon, Alexander J Auty, Dimitri Chekulaev, Igor V Sazanovich, Michael Towrie, Anthony J H M Meijer, Julia A Weinstein
Modification of light-harvesting units with anchoring groups for surface attachment often compromises light-harnessing properties. Herein, a series of [donor-acceptor-anchor] platinum(II) diimine (bis-)acetylides was developed in order to systematically compare the effect of conjugated versus electronically decoupled modes of attachment of protected anchoring groups on the photophysical properties of light-harvesting units. The first examples of "decoupled" phosphonate diimine PtII complexes are reported, and their properties are compared and contrasted to those of carboxylate analogues studied by a diversity of methods...
December 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28989137/characteristic-of-malocclusion-among-saudi-special-need-group-children
#11
Thamer Alkhadra
INTRODUCTION: The present study analyzed the characteristics of malocclusions, occlusal traits among Special Health care Needs (SHCN) children with Down syndrome (DS) and autism disorder (AD) in Riyadh City, Kingdom of Saudi Arabia. MATERIALS AND METHODS: A total of 100 DS and 100 AD children from five rehabilitation centers in and around Riyadh, Kingdom of Saudi Arabia, were included in the study. Any children with history of ongoing medical treatment, extraction, or orthodontic treatment were excluded from the study...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28943355/boron-based-inhibitors-of-the-nlrp3-inflammasome
#12
Alex G Baldwin, Jack Rivers-Auty, Michael J D Daniels, Claire S White, Carl H Schwalbe, Tom Schilling, Halah Hammadi, Panichakorn Jaiyong, Nicholas G Spencer, Hazel England, Nadia M Luheshi, Manikandan Kadirvel, Catherine B Lawrence, Nancy J Rothwell, Michael K Harte, Richard A Bryce, Stuart M Allan, Claudia Eder, Sally Freeman, David Brough
NLRP3 is a receptor important for host responses to infection, yet is also known to contribute to devastating diseases such as Alzheimer's disease, diabetes, atherosclerosis, and others, making inhibitors for NLRP3 sought after. One of the inhibitors currently in use is 2-aminoethoxy diphenylborinate (2APB). Unfortunately, in addition to inhibiting NLRP3, 2APB also displays non-selective effects on cellular Ca2+ homeostasis. Here, we use 2APB as a chemical scaffold to build a series of inhibitors, the NBC series, which inhibit the NLRP3 inflammasome in vitro and in vivo without affecting Ca2+ homeostasis...
November 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28903877/exploring-the-role-of-small-scale-livestock-keepers-for-national-biosecurity-the-pig-case
#13
Carla Correia-Gomes, Madeleine K Henry, Harriet K Auty, George J Gunn
Small-scale keepers are less likely to engage with production organisations and may therefore be less aware of legislation, rules and biosecurity practices which are implemented in the livestock sector. Their role in the transmission of endemic and exotic diseases is not well studied, but is believed to be important. The authors use small-scale pig keepers in Scotland as an example of how important small-scale livestock keepers might be for national biosecurity. In Scotland more than two thirds of pig producers report that they keep less than 10 pigs, meaning that biosecurity practices and pig health status on a substantial number of holdings are largely unknown; it is considered important to fill this knowledge gap...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28812006/main-pulmonary-artery-trifurcation-in-association-with-persistent-right-common-pulmonary-vein-a-piece-of-embryological-puzzle
#14
Venkatraman Bhat, Karthik Gadabanahalli, Onkar Auti
No abstract text is available yet for this article.
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28761045/salmonella-typhimurium-induced-il-1-release-from-primary-human-monocytes-requires-nlrp3-and-can-occur-in-the-absence-of-pyroptosis
#15
Catherine E Diamond, Keith Weng Kit Leong, Maurizio Vacca, Jack Rivers-Auty, David Brough, Alessandra Mortellaro
Large molecular complexes known as inflammasomes regulate the release of IL-1β from immune cells in response to infection and injury. Salmonella typhimurium infection is reported to activate NLRP3 and NLRC4 inflammasomes which are subsequently involved in pyroptosis of the cell and pathogen clearance. However, the response to S. typhimurium in primary human monocytes has not been studied in detail. The aim of this study was to investigate the effect of S. typhimurium on inflammasomes in primary human monocytes...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710167/detecting-and-managing-new-animal-health-threats-how-vulnerable-are-we
#16
EDITORIAL
Carla Correia-Gomes, Harriet K Auty
No abstract text is available yet for this article.
July 15, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28690057/effects-of-depleting-ionic-strength-on-31-p-nuclear-magnetic-resonance-spectra-of-micellar-casein-during-membrane-separation-and-diafiltration-of-skim-milk
#17
Mattia Boiani, Padraig McLoughlin, Mark A E Auty, Richard J FitzGerald, Phil M Kelly
Membrane separation processes used in the concentration and isolation of micellar casein-based milk proteins from skim milk rely on extensive permeation of its soluble serum constituents, especially lactose and minerals. Whereas extensive literature exists on how these processes influence the gross composition of milk proteins, we have little understanding of the effects of such ionic depletion on the core structural unit of micellar casein [i.e., the casein phosphate nanocluster (CPN)]. The (31)P nuclear magnetic resonance (NMR) is an analytical technique that is capable of identifying soluble and organic forms of phosphate in milk...
September 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28493417/retroesophageal-course-of-left-brachiocephalic-vein-the-garland-vein
#18
Onkar B Auti, Pradeep K Kaushik, Prakash Ramachandra, Vimal Raj
No abstract text is available yet for this article.
May 10, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28451090/a-rare-complication-of-pulmonary-tuberculosis-pulmonary-venous-thrombosis-with-atrial-extension
#19
Onkar Balasaheb Auti, Ranganath R, Murali Mohan Bv, Vimal Raj
Pulmonary tuberculosis (TB) is serious public health problem in India and worldwide. The mortality rate in pulmonary TB is high in those with advanced disease and in presence of complications. It presents with wide variety of complications of which haematological complications are rare. Many cases were reported pulmonary TB associated with deep venous thrombosis, hepatic and portal venous thrombosis, central retinal venous thrombosis and sagittal sinus thrombosis in TB meningitis. We report a rare case of pulmonary TB with pulmonary venous thrombosis and atrial extension...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28399478/quantifying-environmental-and-personal-risks-of-nanotechnology-for-industry
#20
REVIEW
Andrew R Auty
Regulators continue to pursue a comprehensive, generalisable, transparent, reliable, accurate and universally commended injury risk assessment methodology for nanomaterials. After a decade of intensive effort, it emerges that many of the prototype risk metrics are uninformative. This situation has given rise to practical, if non-validated, guidance in the form of control banding recommendations. While informative these are often logically deficient and take no account of risk context as captured in the concept of risk appetite...
August 2017: Current Opinion in Biotechnology
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