Luiggi Müller Madalosso, Franciéle Romero Machado Balok, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Lucas Gabriel Backes, Elizabeth Sabryna Sarquis Escalante, Fernanda Vilhalba Benites, Francisco Andrey da Silva E Silva, Hecson Jesser Segat, Silvana Peterini Boeira
Mycotoxins are toxic fungal metabolites and are responsible for contaminating several foods. The intake of foods contaminated by these substances is related to hepatotoxicity and carcinogenic effects, possibly due to increasing oxidative stress. The current study evaluated Pitaya fruit juice's antioxidant effects on oxidative damage aflatoxin B1 (AFB1)-induced. Rats received 1.5 mL of Pitaya juice via gavage (for 30 days), and on the 31st day, they received AFB1 (250 µg/kg, via gavage). Forty-eight hours after the AFB1 dose, rats were euthanized for dosages of alanine transaminase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP); dosage of oxidative markers (thiobarbituric acid reactive species (TBARS), reactive species (RS)) and antioxidant defenses (catalase (CAT), superoxide dismutase (SOD), Glutathione S-transferase (GST) activities and Glutathione (GSH)) levels in the liver; and detection of Heat shock protein 70 (Hsp-70) and nuclear factor- erythroid 2-related factor 2 (Nrf2) immunocontent in the liver...
August 24, 2023: Journal of Fungi (Basel, Switzerland)