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Pustular psoriasis

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https://www.readbyqxmd.com/read/28776328/acute-generalized-exanthematous-pustulosis-and-polyarthritis-associated-with-a-novel-card14-mutation
#1
Sebastian Podlipnik, Raul Castellanos-Moreira, Helena Florez-Enrich, Juan Ignacio Arostegui, José Manuel Mascaró
Acute generalised exanthematous pustulosis (AGEP) is a rare toxicoderma characterised by an acute onset rash, with many sterile pustules on the surface, high fever and increased acute phase reactants. We report the case of a patient who presented to the dermatology department with an AGEP and polyarthritis, in which a novel CARD14 mutation was identified. The pathophysiological mechanism of AGEP remains unclear, although mutations in the IL36RN gene have been identified in a small subset of AGEP patients. Similarly, mutations in the CARD14 gene have been linked to pustular types of psoriasis and familiar cases of pityriasis rubra pilaris; however, there are no reports associating mutations in the CARD14 gene with AGEP...
August 3, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28752373/skin-manifestations-of-rheumatoid-arthritis-juvenile-idiopathic-arthritis-and-spondyloarthritides
#2
REVIEW
Carolyn Jean Chua-Aguilera, Burkhard Möller, Nikhil Yawalkar
Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients...
July 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28747603/autoinflammatory-diseases-in-dermatology-ditra-and-camps
#3
Kazumitsu Sugiura
  Deficiency of interleukin thirty-six receptor antagonist (DITRA) and CARD14 mediated psoriasis (CAMPS) are autoinflammatory diseases in dermatology. The causative genes of DITRA and CMAPS have been identified recently. In this paper, IL36RN and CARD14, the causative gene for DITRA and CAMPS, respectively were explained. In addition, clinical features and therapies for generalized pustular psoriasis not associated with psoriasis vulgaris (GPP without PsV), and pityriasis rubra pilaris type V (PRP type V) were described...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28738209/psoriasis-a-mixed-autoimmune-and-autoinflammatory-disease
#4
REVIEW
Yun Liang, Mrinal K Sarkar, Lam C Tsoi, Johann E Gudjonsson
In recent years marked progress has been made in our understanding of the critical biologic and immunologic pathways involved in psoriasis. Genetic studies have demonstrated that susceptibility to psoriasis involves components of both the adaptive and innate immune system and not surprisingly activation of both of these arms of the immune system is found in psoriatic skin. While adaptive immune responses predominate in chronic plaque psoriasis, innate and autoinflammatory responses dominate in pustular forms of psoriasis, with other clinical subtypes extending on a spectrum between plaque and pustular psoriasis...
July 21, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28726542/generation-and-functional-characterization-of-anti-human-and-anti-mouse-il-36r-antagonist-monoclonal-antibodies
#5
Rajkumar Ganesan, Ernest L Raymond, Detlev Mennerich, Joseph R Woska, Gary Caviness, Christine Grimaldi, Jennifer Ahlberg, Rocio Perez, Simon Roberts, Danlin Yang, Kavita Jerath, Kristopher Truncali, Lee Frego, Eliud Sepulveda, Priyanka Gupta, Su-Ellen Brown, Michael D Howell, Keith A Canada, Rachel Kroe-Barrett, Jay S Fine, Sanjaya Singh, M Lamine Mbow
Deficiency of interleukin (IL)-36 receptor antagonist (DITRA) syndrome is a rare autosomal recessive disease caused by mutations in IL36RN. IL-36R is a cell surface receptor and a member of the IL1R family that is involved in inflammatory responses triggered in skin and other epithelial tissues. Accumulating evidence suggests that IL-36R signaling may play a role in the pathogenesis of psoriasis. Therapeutic intervention of IL-36R signaling offers an innovative treatment paradigm for targeting epithelial cell-mediated inflammatory diseases such as the life-threatening psoriasis variant called generalized pustular psoriasis (GPP)...
July 20, 2017: MAbs
https://www.readbyqxmd.com/read/28699044/uva1-vs-narrowband-uvb-phototherapy-in-the-treatment-of-palmoplantar-pustulosis-a-pilot-randomized-controlled-study
#6
Li-Na Su, Jie Ren, Shi-Meng Cheng, Jian-Lan Liu, Yang-Feng Ding, Ning-Wen Zhu
UVA1 phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of palmoplantar pustulosis (PPP). The purpose of this study was to compare the efficacy of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of PPP. Patients with PPP were randomly assigned to either UVA1 or NB-UVB therapy according to a left-right randomization table. Both treatments were performed three times weekly for up to 30 sessions. Clinical evaluation was based on the Palmoplantar Pustular Psoriasis Area and Severity Index (PPPASI) score...
July 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28650001/brodalumab-the-first-anti-il-17-receptor-agent-for-psoriasis
#7
L Puig
Psoriasis is a chronic immune-mediated inflammatory skin disease in which the alteration of the interleukin-23 (IL-23)/IL-17 cytokine axis appears to be crucial from a pathogenetic perspective. This has been confirmed by the efficacy of monoclonal antibodies blocking IL-17A, such as secukinumab and ixekizumab. Brodalumab is a human anti-IL-17 receptor A (IL-17RA) monoclonal antibody that inhibits the biological activity of IL-17A, IL-17F and other IL-17 isoforms, and has been approved (210 mg s.c. at weeks 0, 1, 2 and every 2 weeks thereafter) for the treatment of psoriasis vulgaris, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma in Japan (Lumicef)...
May 2017: Drugs of Today
https://www.readbyqxmd.com/read/28629688/generalized-pustular-psoriasis
#8
Hideyuki Kosumi, Takamasa Ito, Yasuyuki Fujita, Kentaro Izumi, Yuka Maya, Teruki Yanagi, Ken Natsuga, Hideyuki Ujiie, Satoru Shinkuma, Toshifumi Nomura, Naoya Sadanobu, Hiroshi Shimizu
No abstract text is available yet for this article.
June 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28585707/early-relapse-of-psoriasis-after-stopping-brodalumab-a-retrospective-cohort-study-in-77-patients
#9
M Masson Regnault, M-P Konstantinou, A Khemis, Y Poulin, M Bourcier, F Amelot, C Bulaï Livideanu, C Paul
BACKGROUND: Biological agents targeting IL-17 are very effective for clearing moderate to severe psoriasis. There is limited information regarding the frequency and pattern of psoriasis relapse upon treatment cessation. OBJECTIVE: To investigate the pattern of psoriasis recurrence in patients who were treated with brodalumab following Amgen's decision to stop the clinical program in June 2015. MATERIALS AND METHODS: Between June 2015 and March 2016, we constructed a retrospective multicenter cohort study including patients who were treated with brodalumab in Amgen's protocols after the abrupt interruption of the drug development program...
June 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28585342/european-consensus-statement-on-phenotypes-of-pustular-psoriasis
#10
REVIEW
Alexander A Navarini, A David Burden, Francesca Capon, Ulrich Mrowietz, Luis Puig, Sulev Köks, Külli Kingo, Catherine Smith, Jonathan N Barker
Pustular psoriasis (PP) is a group of inflammatory skin conditions characterized by infiltration of neutrophil granulocytes in the epidermis to such an extent that clinically visible sterile pustules develop. Because of clinical co-incidence, PP is currently grouped with psoriasis vulgaris (PV). However, PP and PV are phenotypically different, respond differently to treatments, and seem to be distinct on the genetic level. In contrast to PV, the phenotypes of PP are not well defined. Descriptions of each form of PP are discordant among standard dermatology textbooks [1-5], encumbering the collection of phenotypically well-matched groups of patients as well as clinical trials...
June 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28557175/psoriasis-in-patients-with-mycosis-fungoides-a-clinicopathological-study-of-25-patients
#11
V Nikolaou, L Marinos, E Moustou, E Papadavid, A Economidi, E Christofidou, M Gerochristou, A Tasidou, E Economaki, A Stratigos, C Antoniou
BACKGROUND: It has been reported that patients with psoriasis are at increased risk for developing lymphoma including cutaneous T-cell lymphomas (CTCL). However, the comorbidity and the histopathologic correlation of psoriasis and mycosis fungoides (MF) have been less studied. OBJECTIVE: The objective of this study was to investigate the relation between MF and psoriasis. METHODS: We retrospectively reviewed and re-evaluated all MF cases diagnosed and followed in a 16-year period who carried both MF and psoriasis diagnoses...
May 30, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28535721/short-and-long-term-management-of-an-acute-pustular-psoriasis-flare-a-case-report
#12
Jorge R Georgakopoulos, Arvin Ighani, Jensen Yeung
BACKGROUND: Generalised pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH) are chronic, relapsing variants of pustular psoriasis proven to be remarkably challenging to treat. Due to their uncommon presentation, there are few described cases in literature and scarce evidence for management. Further information is needed to help dermatologists formulate treatment plans for patients presenting with such diseases. CASE SUMMARY: We report the case of a 68-year-old man with a 3-year history of psoriasis presenting to our clinic with a severe breakout of GPP and associated ACH...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28502119/neutrophil-to-lymphocyte-ratio-decreases-after-treatment-of-psoriasis-with-therapeutic-antibodies
#13
L Zhang, C Wiles, L R Martinez, G Han
Although neutrophils are a histologic hallmark of psoriasis, it is unclear whether neutrophils are simply effector cells or drive pathogenesis. A recent psoriasis study with murine models evaluated various chemokines, lipids, and cytokines proposing that neutrophils are key players in positive feedback loops perpetuating the disease.(1) Additionally, when neutrophils are depleted in pustular psoriasis, the disease drastically improves.(2) There is mounting evidence supporting the use of neutrophil to lymphocyte ratio (NLR) as a marker of inflammation in active psoriasis...
May 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28490011/new-interleukins-in-psoriasis-and-psoriatic-arthritis-patients-the-possible-roles-of-interleukin-33-to-interleukin-38-in-disease-activities-and-bone-erosions
#14
Jiang Li, Lei Liu, Wenlong Rui, Xiangyu Li, Dandan Xuan, Shucong Zheng, Yiyun Yu, Jiong Zhang, Ning Kong, Xiaoxia Zhu, Hejian Zou, Weiguo Wan, Yu Xue
OBJECTIVES: New interleukins (ILs), especially members of IL-1 and IL-12 families, have recently been reported to be involved in the development and regulation of autoimmune and inflammatory diseases. In this study, we aimed to explore the impact of these new ILs in psoriasis (Ps) and psoriatic arthritis (PsA). METHODS: Forty PsA patients, 20 Ps patients, and 20 healthy controls (HCs) were recruited. Blood samples were obtained for detecting the levels of ILs, IL-12/23p40, and tumor necrosis factor α (TNF-α)...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28452100/pediatric-psoriasis-should-we-be-concerned-with-comorbidity-cross-sectional-study
#15
Awatef Kelati, Hanane Baybay, Adil Najdi, Safae Zinoune, Fatima Z Mernissi
BACKGROUND: Similarly to psoriasis in adults, recent research has linked psoriasis to several comorbidities in children. The aim of this study was therefore to describe comorbidities associated with pediatric psoriasis, to investigate their relationship with psoriasis characteristics and severity, and to perform a review of the literature. METHODS: A cross-sectional study was performed on a sample of Moroccan children with psoriasis, in 2014-2016. RESULTS: A total of 64 pediatric psoriasis patients had metabolic comorbidities in association with psoriasis; 20 children had non-metabolic comorbidities; and 76 children had no comorbidity...
April 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28439342/secukinumab-in-the-treatment-of-palmoplantar-nail-scalp-and-pustular-psoriasis
#16
REVIEW
April W Armstrong, Ron Vender, Leon Kircik
No abstract text is available yet for this article.
June 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28419647/a-dramatic-response-to-a-single-dose-of-infliximab-in-a-patient-with-prolonged-pustular-psoriasis-derived-from-inverse-psoriasis
#17
Mengmeng Li, Weiwei Dai, Wei Yan, Yuanzhen Liu, Lian Wang, Wei Li
We report a case of a 25-year-old Chinese man with an exceptionally prolonged history of pustular psoriasis derived from inverse psoriasis who was unsatisfied with conventional treatment and was successfully treated with a single dose of infliximab without noticeable adverse effects. No recurrence or flaring was observed after 3 months of follow-up. This case illustrates that infliximab may be an effective and safe therapeutic option for patients with refractory pustular psoriasis derived from inverse psoriasis...
April 17, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28412864/cutaneous-allergic-drug-reactions-update-on-pathophysiology-diagnostic-procedures-and-differential-diagnosic
#18
Galina Balakirski, Hans F Merk
Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions...
April 27, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28407292/internalized-stigma-in-psoriasis-a-multicenter-study
#19
Erkan Alpsoy, Mualla Polat, Bilge FettahlıoGlu-Karaman, Ayse Serap Karadag, Pelin Kartal-Durmazlar, Basak YalCın, Selma Emre, Didem Didar-Balcı, Asli Bilgic-Temel, Ercan Arca, Rafet Koca, Kamer Gunduz, Murat Borlu, Tulin Ergun, Seval Dogruk-Kacar, Ayca Cordan-Yazici, Pınar Dursun, Ozlem BilgiC, Serap Gunes-Bilgili, Neslihan Sendur, Ozge Baysal, Ibrahim Halil-Yavuz, Gizem Yagcioglu, Ertan Yilmaz, Ufuk Kavuzlu, Yesim Senol
Internalized stigma is the adoption of negative attitudes and stereotypes of the society regarding a person's illness. It causes decreased self-esteem and life-satisfaction, increased depression and suicidality, and difficulty in coping with the illness. The primary aim of this study was to investigate the internalized stigma state of psoriatic patients and to identify the factors influencing internalized stigma. The secondary aim was to identify the correlation of internalized stigma with quality of life and perceived health status...
April 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28369922/granulocyte-and-monocyte-apheresis-can-control-juvenile-generalised-pustular-psoriasis-with-mutation-of-the-il36rn-gene
#20
Y Koike, M Okubo, T Kiyohara, R Fukuchi, Y Sato, S Kuwatsuka, T Takeichi, M Akiyama, K Sugiura, A Utani
Patients with 'deficiency of the interleukin-36 receptor antagonist' (DITRA), caused by mutation of the IL36RN gene, exhibit psoriatic phenotypes, typically generalised pustular psoriasis (GPP). We report a paediatric case with DITRA, whose cutaneous lesions varied from psoriasis vulgaris in infancy to annular pustular psoriasis with acute exacerbation to GPP at 13 years of age. Conventional systemic treatments for GPP, which include oral retinoids, cyclosporine and methotrexate, are controversial in paediatric cases, because of their adverse effects and uncertain long-time consequences...
March 30, 2017: British Journal of Dermatology
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