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Pustular psoriasis

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https://www.readbyqxmd.com/read/29681811/a-case-of-ceftriaxone-induced-acute-generalized-exanthematous-pustulosis-generalized-pustular-psoriasis-overlap
#1
Jianfeng Zheng, Yunlu Gao, Xuemei Yi, Yangfeng Ding
Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this report the authors have reported a 40-year-old male patient with primary syphilis who developed generalized pustular dermatosis after the use of ceftriaxone...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29619998/association-of-il36rn-mutation-with-clinical-features-therapeutic-response-to-acitretin-and-frequency-of-recurrence-in-patients-with-generalized-pustular-psoriasis
#2
Teng Zhu, Hongzhong Jin, Dan Shu, Feng Li, Chao Wu
Previous studies have revealed that IL36RN mutations play a pivotal role in the pathogenesis of generalized pustular psoriasis (GPP), however, the clinical relevance is unclear. To investigate the correlation between IL36RN mutations and clinical features, recurrence frequency, and therapeutic response to acitretin in GPP patients with long-term follow-up. This retrospective cohort study, lasting 2-4 years, included 61 GPP and 48 psoriasis vulgaris (PV) patients. Sequence analysis of all five exons of the IL36RN gene revealed two genetic variants (c...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29595236/the-heterogeneous-mutational-landscape-of-pustular-psoriasis
#3
F Capon
No abstract text is available yet for this article.
March 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29573491/generalized-pustular-psoriasis-a-review-and-update-on-treatment
#4
REVIEW
K M Hoegler, A M John, M Z Handler, R A Schwartz
Generalized pustular psoriasis is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, generalized pustular psoriasis can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections, and environmental triggers. The interleukin family and caspase recruitment domain family have been implicated in the pathogenesis. Other forms of pustular psoriasis include impetigo herpetiformis, palmoplantar pustular psoriasis, annular pustular psoriasis, and acrodermatitis continua of Hallopeau...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29569397/guselkumab-a-human-interleukin-23-monoclonal-antibody-in-japanese-patients-with-generalized-pustular-psoriasis-and-erythrodermic-psoriasis-efficacy-and-safety-analyses-of-a-52-week-phase-3-multicenter-open-label-study
#5
Shigetoshi Sano, Hiroshi Kubo, Hitomi Morishima, Ryosuke Goto, Richuan Zheng, Hidemi Nakagawa
Generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP) are the rare and severe subtypes of psoriasis, which are often difficult to treat. The aim of this phase 3, open-label study was to evaluate efficacy and safety of guselkumab, a human interleukin-23 monoclonal antibody, in Japanese patients with GPP and EP. Guselkumab 50 mg was administrated to GPP (n = 10) and EP (n = 11) patients at weeks 0, 4 and thereafter every 8 weeks (q8w). Beginning at week 20, patients were escalated to 100 mg q8w if they met the dose escalation criteria...
March 22, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29565192/pharmacotherapeutic-approaches-for-treating-psoriasis-in-difficult-to-treat-areas
#6
Dario Kivelevitch, Jillian Frieder, Ian Watson, So Yeon Paek, M Alan Menter
Despite great therapeutic advancements in psoriasis, four notable difficult-to-treat areas including the scalp, nails, intertriginous (including genitals), and palmoplantar regions, pose a challenge to both physicians and patients. Localized disease of these specific body regions inflicts a significant burden on patients' quality of life and requires an adequate selection of treatments. Areas covered: This manuscript discusses appropriate therapies and important treatment considerations for these difficult-to-treat areas based on the available clinical data from the literature...
March 22, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29531495/pustulotic-arthro-osteitis-sonozaki-syndrome-a-case-report-and-review-of-literature
#7
Reyhan Kose, Taskin Senturk, Gokhan Sargin, Songul Cildag, Yasemin Kara
Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different entity. The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome should be considered in the differential diagnosis...
February 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29520163/pustular-psoriasis-of-pregnancy-current-perspectives
#8
REVIEW
Megha K Trivedi, Alexandra R Vaughn, Jenny E Murase
Pustular psoriasis of pregnancy (PPP) is a life-threatening condition for both the pregnant mother and fetus, and must be efficiently and accurately diagnosed and treated. This condition has historically been classified as a unique, separate dermatosis of pregnancy. However, current opinion and data suggest that it may be a variant of generalized pustular psoriasis. PPP typically occurs in the third trimester and is characterized by widespread coalescent pustules, desquamation, and systemic symptoms. Clinical features and histopathologic evaluation aid in diagnosis...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29484893/generalized-pustular-psoriasis-induced-by-infliximab-in-a-patient-with-inflammatory-bowel-disease
#9
Dalal Almutairi, Christopher Sheasgreen, Adam Weizman, Afsaneh Alavi
The incidence of anti-tumour necrosis factor (TNF)-induced psoriasiform eruptions has ranged in the literature between 0.5% and 10.9% of patients with inflammatory bowel disease (IBD). The morphology of the rash varies, with plaque psoriasis being the most common form. Generalized pustular eruption is reported in 10.2% of cases of anti-TNF-induced psoriasis. We are reporting a unique case of anti-TNF-associated psoriasiform eruption due to the severity of the rash presenting as a generalized pustular eruption in association with plaque psoriasiform rash requiring systemic therapy...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29470738/prevalence-and-type-ii-diabetes-associated-factors-in-psoriatic-arthritis
#10
Rubén Queiro, Andrés Lorenzo, Estefanía Pardo, Anahy Brandy, Pablo Coto, Javier Ballina
Diabetes is a common cardiovascular risk factor in psoriatic arthritis (PsA). Although the prevalence of diabetes is high, the factors associated with it in PsA are poorly understood. We aimed to analyse the prevalence of type II diabetes and diabetes-associated factors in a hospital-based population with PsA. This cross-sectional study included 340 consecutive patients attended in a tertiary care hospital. The prevalence of diabetes was compared to that of 600 outpatients without inflammatory conditions. To analyse diabetes-associated factors, odds ratio (OR) values were calculated by conditional logistic regression analysis...
February 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29454537/an-infant-with-generalized-pustular-psoriasis-and-geographic-tongue-had-a-heterozygous-il36rn-mutation-and-igg2-deficiency
#11
Risako Oi, Takuya Takeichi, Yusuke Okuno, Daiei Kojima, Kyoko Sugawara, Michihiro Kono, Hideki Muramatsu, Masashi Akiyama
No abstract text is available yet for this article.
February 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29447638/pediatric-pustular-psoriasis-responsive-to-cyclosporine-bridged-to-etanercept-a-treatment-approach
#12
Corey Georgesen, Horatio Wildman, Xuan Wang, Cynthia Magro
Pustular psoriasis occurs rarely in children but can present with acute toxicity requiring inpatient admission. For the best approach, medical providers should have an evidence based and systematic treatment algorithm in their armamentarium. Toillustrate this point, we describe a 13-year-old girl who was admitted with generalized pustular psoriasis and who responded dramatically to "wet wrap" therapy and cyclosporine bridged to etanercept. Using this case example, we highlight the three most important considerations in any patient with new onset pustularpsoriasis: avoidance of disease complications, acute "rescue" therapy, and maintenance therapy...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29434599/rna-seq-analysis-of-il-1b-and-il-36-responses-in-epidermal-keratinocytes-identifies-a-shared-myd88-dependent-gene-signature
#13
William R Swindell, Maria A Beamer, Mrinal K Sarkar, Shannon Loftus, Joseph Fullmer, Xianying Xing, Nicole L Ward, Lam C Tsoi, Michelle J Kahlenberg, Yun Liang, Johann E Gudjonsson
IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, or IL-36G. We identified some early IL-1B-specific responses (8 h posttreatment), but nearly all late IL-1B responses were replicated by IL-36 cytokines (24 h posttreatment). Type I and II interferon genes exhibited time-dependent response patterns, with early induction (8 h) followed by no response or repression (24 h)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29422292/autoinflammatory-keratinization-diseases-an-emerging-concept-encompassing-various-inflammatory-keratinization-disorders-of-the-skin
#14
Masashi Akiyama, Takuya Takeichi, John A McGrath, Kazumitsu Sugiura
Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC)...
February 1, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29420246/ards-complicating-pustular-psoriasis-treatment-with-low-dose-corticosteroids-vitamin-c-and-thiamine
#15
Paul Ellis Marik, Ashleigh Long
We report the case of a 45-year-old Caucasian woman with a history of psoriasis, admitted to our Medical intensive care unit following the acute onset of diffuse rash and progressive dyspnoea and hypoxaemia requiring escalating respiratory support (continuous positive airway pressure of 10 cm H2 O). Her chest X-ray was consistent with findings of non-cardiogenic pulmonary oedema. Echocardiogram was normal. Dermatology considered her skin lesions to be consistent with psoriasis vulgaris with pustular flare. In the absence of an identifiable cause for her respiratory failure, she was diagnosed with acute respiratory distress syndrome due to her psoriatic flare...
February 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29419896/comparison-of-effectiveness-and-safety-of-excimer-lamp-versus-topical-calcipotriol-clobetasol-propionate-combination-in-the-treatment-of-palmoplantar-psoriasis
#16
Abhishek Thakur, Anuradha Bishnoi, Sunil Dogra, Tarun Narang
BACKGROUND: Very few studies have assessed the efficacy of excimer treatment in palmoplantar psoriasis (PPP), and none has compared the excimer with calcipotriol-clobetasol combination. PURPOSE: To compare the effectiveness and safety of excimer lamp versus topical ointment containing calcipotriol (0.005% w/w) and clobetasol propionate (0.05% w/w) combination in PPP. METHODS: This right-left randomization trial included 36 patients with PPP, who received treatment with excimer lamp (twice weekly) on one side and calcipotriol-clobetasol combination once daily on another side for 12 weeks, followed by 8 weeks follow-up...
February 8, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29395573/increased-levels-of-lipocalin-2-in-palmoplantar-pustular-psoriasis
#17
Kerstin Wolk, Yvonne Frambach, Arnd Jacobi, Dagmar Wilsmann-Theis, Sandra Phillipp, Ellen Witte-Händel, Jörg Wenzel, Rotraut Mössner, Robert Sabat
BACKGROUND: Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles. OBJECTIVE: To identify and characterize pathogenetic players in PPP. METHODS: Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Healthy participants served as controls. Analysis of patient samples and cultured primary skin cells was performed by ELISA, qRT-PCR, and immunohistochemistry...
January 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29380726/genetic-background-and-therapeutic-response-in-generalized-pustular-psoriasis-patients-treated-with-granulocyte-and-monocyte-adsorption-apheresis
#18
Hidenori Ohnishi, Tomonori Kadowaki, Yoko Mizutani, Emi Nishida, Rie Tobita, Namiko Abe, Yukie Yamaguchi, Hikaru Eto, Masaru Honma, Takuro Kanekura, Yukari Okubo, Mariko Seishima, Toshiyuki Fukao, Shigaku Ikeda
No abstract text is available yet for this article.
January 30, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29364440/how-relevant-are-vascular-endothelial-growth-factor-and-intercellular-adhesion-molecule-in-the-systemic-capillary-leak-syndrome-of-psoriasis
#19
REVIEW
Aline Lopes Bressan, Daniele Pereira, Paula Mota Medeiros, Sueli Carneiro, Luna Azulay-Abulafia
Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease...
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29349534/psoriasis-from-pathogenesis-to-targeted-therapies
#20
REVIEW
Curdin Conrad, Michel Gilliet
Over the last decade, the management of psoriasis has witnessed a paradigm shift. Thanks to the increasing knowledge about the pathogenesis of psoriasis, targeted treatments with monoclonal antibodies have been developed. These antibodies, which target the pathogenic TNF/IL-23/IL-17-pathway, were shown to be safe and efficacious in the management of most patients with moderate to severe chronic plaque psoriasis. Recently, molecular and genetic studies in pustular and erythrodermic psoriasis have identified additional inflammatory pathways, providing evidence that psoriasis is a heterogeneous disease and highlighting the requirement for personalized disease characterization for treatment optimization...
February 2018: Clinical Reviews in Allergy & Immunology
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