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https://www.readbyqxmd.com/read/29594193/expression-of-intrahepatic-cd3-cd4-and-cd8-t-cells-in-biliary-atresia
#1
Behairy E Behairy, Nermine Ehsan, Magdy Anwer, Alif Allam, Ibramem El-Henawy, Nesreen Abdel Hameed, Haidy M Zakaria
Aim of the study: Assessment of the expression of cluster of differentiation (CD)3, CD4, and CD8 T cells in biliary atresia (BA) cases in comparison to neonatal cholestasis other than BA. Material and methods: This study included 79 patients: 34 patients with BA (BA group) and 35 patients with neonatal cholestasis due to causes other than BA (cholestasis group), and 10 normal liver donor as a control group. Immunohistochemical staining or CD3, CD4, and CD8 T cells in liver tissues for the 3 groups were evaluated...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29588241/facet-joint-fixation-and-alif-dlif-or-tlif-for-treatment-of-degenerative-lumbar-disc-diseases-retrospective-cohort-study-of-a-new-minimally-invasive-technique
#2
Evgenii Belykh, Andrey A Kalinin, Nikolay L Martirosyan, Talgat Kerimbayev, Nicholas Theodore, Mark C Preul, Vadim A Byvaltsev
BACKGROUND: Anterior, direct lateral and transforaminal lumbar interbody fusions (ALIF, DLIF, and TLIF) are usually combined with posterior fixation to treat degenerative spinal diseases. Outcomes of ALIF, TLIF, or DLIF combined with a new wedge-shaped, interfacet cage-plate have not been reported. We assessed early clinical outcomes of patients treated with interbody fusion and facet fixation using a titanium wedge-shaped cage-plate. METHODS: This retrospective observational cohort study included patients (n=80) who underwent 1-level interbody fusion and facet joint fixation via ALIF (n=24) or DLIF (n=26) with bilateral facet fixation or TLIF with ipsilateral pedicle screws and contralateral facet fixation (n=30)...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29529003/selective-anterior-lumbar-interbody-fusion-for-low-back-pain-associated-with-degenerative-disc-disease-versus-nonsurgical-management
#3
John P Kleimeyer, Ivan Cheng, Todd F Alamin, Serena S Hu, Thomas Cha, Vijay Yanamadala, Kirkham B Wood
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To evaluate the long-term outcomes of selective one- to two-level anterior lumbar interbody fusions (ALIFs) in the lower lumbar spine versus continued nonsurgical management. SUMMARY OF BACKGROUND DATA: Low back pain associated with lumbar intervertebral disc degeneration is common with substantial economic impact, yet treatment remains controversial. Surgical fusion has previously provided mixed results with limited durable improvement of pain and function...
March 9, 2018: Spine
https://www.readbyqxmd.com/read/29508007/-complications-of-the-lumbosacral-junction-in-adult-deformity-surgery-indications-and-technique-for-posterior-and-anterior-revision-surgery
#4
REVIEW
A Tateen, J Bogert, H Koller, A Hempfing
BACKGROUND: Surgical correction of ASD can be challenging. The indication for surgery is individual and after specification of the therapeutic goals, detailed planning of the surgery is essential to achieve a good postoperative result. COMPLICATIONS AND INDICATION: The reasons for the comparatively high complication rate are well investigated and are often located at the lumbosacral junction. In addition to negative general factors like osteoporosis, especially undercorrection of the sagittal profile and insufficient lumbo-pelvic stabilization are causative...
March 5, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29505978/clinical-and-radiological-outcomes-after-stand-alone-alif-for-single-l5-s1-degenerative-discopathy-using-a-peek-cage-filled-with-hydroxyapatite-nanoparticles-without-bone-graft
#5
Gilles Norotte, Carlos Barrios
OBJECTIVE: Recent improvements in cage designs with integral fixation and screw attachments have made stand-alone ALIF a viable option with several possible advantages. The aim of this study was to confirm the efficacy and safety of a PEEK cage filled with hydroxyapatite nanoparticles without adding a bone graft for stand-alone ALIF in the treatment of L5-S1 isolated degenerative disc discopathy (DDD). PATIENTS AND METHODS: Sixty-five patients who required surgery for DDD were evaluated...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29492369/two-year-outcomes-from-a-single-surgeon-s-learning-curve-experience-of-oblique-lateral-interbody-fusion-without-intraoperative-neuromonitoring
#6
Kamal Woods, Ahtziri Fonseca, Larry E Miller
Introduction Oblique lumbar interbody fusion (OLIF) is a newer procedure that avoids the psoas and lumbosacral plexus due to its oblique trajectory into the retroperitoneal space. While early experience with OLIF is reassuring, the longer-term clinical efficacy has not been well established. The purpose of this study was to describe two-year clinical outcomes with OLIF performed by a single surgeon during the learning curve without the aid of the neuromonitoring. Materials and methods Chart review was performed for the consecutive patients who underwent OLIF by a single surgeon...
December 22, 2017: Curēus
https://www.readbyqxmd.com/read/29463273/outcomes-of-oblique-lateral-interbody-fusion-for-degenerative-lumbar-disease-in-patients-under-or-over-65-years-of-age
#7
Chengzhen Jin, Milin S Jaiswal, Sin-Soo Jeun, Kyeong-Sik Ryu, Jung-Woo Hur, Jin-Sung Kim
BACKGROUND: Oblique lateral interbody fusion (OLIF) offers the solution to problems of anterior lumbar interbody fusion (ALIF) and lateral lumbar interbody fusion (LLIF). However, OLIF technique for degenerative spinal diseases of elderly patients has been rarely reported. The objective of this study was to determine the clinical and radiological results of OLIF technique for degenerative spinal diseases in patients under or over 65 years of age. METHODS: Sixty-three patients who underwent OLIF procedure were enrolled, including 29 patients who were less than 65 years of age and 34 patients who were over 65 years of age...
February 20, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29454985/a-non-toxic-microbial-surfactant-from-marinobacter-hydrocarbonoclasticus-sdk644-for-crude-oil-solubilization-enhancement
#8
Billal Zenati, Alif Chebbi, Abdelmalek Badis, Kamel Eddouaouda, Hocine Boutoumi, Mohamed El Hattab, Dorra Hentati, Manel Chelbi, Sami Sayadi, Mohamed Chamkha, Andrea Franzetti
This study aims to investigate the ability of a biosurfactant produced by Marinobacter hydrocarbonoclasticus strain SdK644 isolated from hydrocarbon contaminated sediment to enhance the solubilization rate of crude oil contaminated seawater. Phylogenetic analysis shows that strain SdK644 was very closely related to M. hydrocarbonoclasticus with 16S rRNA gene sequence similarity of 97.44%. Using waste frying oil as inducer carbon source, the producing biosurfactant by strain SdK644 was applied to improve crude oil solubilization in seawater...
February 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29415435/review-of-current-cell-penetrating-antibody-developments-for-hiv-1-therapy
#9
REVIEW
Muhamad Alif Che Nordin, Sin-Yeang Teow
The discovery of highly active antiretroviral therapy (HAART) in 1996 has significantly reduced the global mortality and morbidity caused by the acquired immunodeficiency syndrome (AIDS). However, the therapeutic strategy of HAART that targets multiple viral proteins may render off-target toxicity and more importantly results in drug-resistant escape mutants. These have been the main challenges for HAART and refinement of this therapeutic strategy is urgently needed. Antibody-mediated treatments are emerging therapeutic modalities for various diseases...
February 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29413610/genipin-stabilized-caseinate-chitosan-nanoparticles-for-enhanced-stability-and-anti-cancer-activity-of-curcumin
#10
Muhamad Alif Razi, Rie Wakabayashi, Yoshiro Tahara, Masahiro Goto, Noriho Kamiya
Nanoparticles formed by the assembly of protein and polysaccharides are of great interest for the delivery of hydrophobic molecules. Herein, the formation of genipin-crosslinked nanoparticles from caseinate (CS) and chitosan (CH) is reported for the delivery of curcumin, a polyphenolic compound from turmeric, to cells. Genipin-crosslinked CS-CH nanoparticles (G-CCNPs) having a diameter of ∼250 nm and a low polydispersity index showed excellent stability over a wide pH range, as indicated by dynamic light scattering and transmission electron microscopic measurements...
January 31, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29413144/sexual-risk-behavior-among-youth-with-bipolar-disorder-identifying-demographic-and-clinical-risk-factors
#11
Megan Krantz, Tina Goldstein, Brian Rooks, John Merranko, Fangzi Liao, Mary Kay Gill, Rasim Diler, Danella Hafeman, Neal Ryan, Benjamin Goldstein, Shirley Yen, Heather Hower, Jeffrey Hunt, Martin Keller, Michael Strober, David Axelson, Boris Birmaher
OBJECTIVE: This study aims to document rates of sexual activity among youth with bipolar spectrum disorder (BD) and to examine demographic and clinical factors associated with first sexual activity and sexual risk behavior during follow-up. METHOD: The sample was drawn from the Course and Outcome of Bipolar Youth (COBY) study of 413 youth 7 to 17 years at baseline who met criteria for bipolar spectrum disorder according to the Schedule for Affective Disorders and Schizophrenia for School-Aged Children...
February 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29411050/-pseudarthrosis-and-construct-failure-after-lumbar-pedicle-subtraction-osteotomy-influence-of-biomechanics-surgical-technique-biology-and-avoidance-strategies
#12
REVIEW
C Birkenmaier
There are numerous factors that can lead to construct failure and pseudarthrosis after corrective pedicle subtraction osteotomy (PSO) in the lumbar spine. Frequently, several factors are of relevance in these problematic cases. This article attempts to explain the surgical, biomechanical and biological aspects that should be understood in order to minimize the risk of pseudarthrosis and construct failure. It addresses technical varieties of the PSO procedure as well as the surgical technique, the choice of rod material and the design of multirod constructs...
February 6, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29369713/alife-and-society-editorial-introduction-to-the-artificial-life-conference-2016-special-issue
#13
Jesús M Siqueiros-García, Tom Froese, Carlos Gershenson, Wendy Aguilar, Hiroki Sayama, Eduardo Izquierdo
No abstract text is available yet for this article.
January 25, 2018: Artificial Life
https://www.readbyqxmd.com/read/29369712/report-on-the-isal-special-session-on-alife-and-society-alife-xv-canc%C3%A3%C2%BAn-mexico-2016
#14
Alexandra Penn
No abstract text is available yet for this article.
January 25, 2018: Artificial Life
https://www.readbyqxmd.com/read/29354736/anterior-lumbar-interbody-fusion-alif-as-an-option-for-recurrent-disc-herniations-a-systematic-review-and-meta-analysis
#15
Kevin Phan, Alan Lackey, Nicholas Chang, Yam-Ting Ho, David Abi-Hanna, Jack Kerferd, Monish M Maharaj, Rhiannon M Parker, Gregory M Malham, Ralph J Mobbs
Background: Recurrent intervertebral disc herniation is a relatively common occurrence after primary discectomy for lumbar intervertebral disc herniation. For recurrent herniations after repeat discectomies, a growing body of evidence suggests that fusion is effective in appropriately selected cases. Theoretically, anterior lumbar interbody fusion (ALIF) allows for comprehensive discectomy, less trauma to spinal nerves and paraspinal muscles and avoidance of the disadvantages of repeat posterior approaches...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29303470/previously-unreported-complications-associated-with-integrated-cage-screws-following-anterior-lumbar-interbody-fusion-report-of-2-cases
#16
Neginder Saini, Mohammad Zaidi, Maureen T Barry, Robert F Heary
Anterior lumbar interbody fusion (ALIF) is a widely performed surgical treatment for various lumbar spine pathologies. The authors present the first reports of virtually identical cases of complications with integrated screws in stand-alone interbody cages. Two patients presented with the onset of S-1 radiculopathy due to screw misplacements following an ALIF procedure. In both cases, an integrated screw from the cage penetrated the dorsal aspect of the S-1 cortical margin of the vertebra, extended into the neural foramen, and injured the traversing left S-1 nerve roots...
March 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29290134/minimally-invasive-anterior-and-lateral-transpsoas-approaches-for-closed-reduction-of-grade-ii-spondylolisthesis-initial-clinical-and-radiographic-experience
#17
David S Xu, Konrad Bach, Juan S Uribe
OBJECTIVE Minimally invasive anterior and lateral approaches to the lumbar spine are increasingly used to treat and reduce grade I spondylolisthesis, but concerns still exist for their usage in the management of higher-grade lesions. The authors report their experience with this strategy for grade II spondylolisthesis in a single-surgeon case series and provide early clinical and radiographic outcomes. METHODS A retrospective review of a single surgeon's cases between 2012 and 2016 identified all patients with a Meyerding grade II lumbar spondylolisthesis who underwent minimally invasive lateral lumbar interbody fusion (LLIF) or anterior lumbar interbody fusion (ALIF) targeting the slipped level...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29288274/stand-alone-anterior-interbody-fusion-for-substitution-of-iliac-fixation-in-long-spinal-fixation-constructs
#18
Morsi Khashan, William Camisa, Sigurd Berven, Jeremi Leasure
INTRODUCTION: The use of distal sacral anchorage solely, in long spinal fusions, may lead to substantial complications. Extending the fixation down to the ilium and the addition of anterior column support are both used to facilitate construct stability and improve fusion rates. In the current study, we aimed to determine whether supplementation of long thoracolumbar fixation constructs with stand-alone anterior interbody fusion (ALIF) cage with embedded screws can eliminate the biomechanical need for iliac screws fixation biomechanically...
April 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29285986/monoclonal-antibody-based-enzyme-immunoassay-for-detection-of-porcine-plasma-in-fish-surimi
#19
Raja Mohd Hafidz Raja Nhari, Nur Fadhilah Khairil Mokhtar, Irwan Hanish, Muhajir Hamid, Muhammad Asraf Alif Mohamed Rashidi, Nur Maisarah Shahidan
Detection of porcine plasma using indirect ELISA was developed using mAb B4E1 for the prevention of their usage in human food that creates religious and health conflicts. The immunoassay has a CV < 20% and did not cross-react to other meat and non-meat proteins. The sensitivity of the assay is 0.25% (w/w) of porcine plasma in spiked raw and cooked fish surimi. The assay did not produce a false positive result for any of the commercial fish surimi tested that were not contain porcine plasma. Determination of a 60-kDa antigenic protein of porcine blood using Western blot confirmed its presence in the plasma fraction of the porcine blood...
January 17, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29229348/bone-morphogenetic-protein-usage-in-anterior-lumbar-interbody-fusion-what-else-can-go-wrong
#20
Elias Elias, Zeina Nasser, Lona Winegan, Terence Verla, Ibrahim Omeis
BACKGROUND: Bone morphogenetic protein (BMP) graft showed promising outcome during early phases of its use. However, unreported adverse events and off-label use shattered its safe profile and raised concerns regarding its indication. In 2008 the U.S. Food and Drug Administration prohibited its use in anterior cervical spine procedures due to the possibility of edema, hematoma, and need to intubate. At the molecular level, BMPs act as multifactorial growth factors playing a role in cartilage, heart, and bone formation...
March 2018: World Neurosurgery
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