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https://www.readbyqxmd.com/read/29904725/serum-level-of-interleukin-13-receptor-alpha-2-in-infants-with-biliary-atresia-is-it-of-value
#1
Nermin Adawy, Hanaa El-Araby, Alif Allam, Soha Elshenawy, Mohammed Khedr, Yasmine Ibrahim, Haidy M Zakaria
Aim of the study: We aimed to assess the utility of serum level IL-13Rα2 receptors as a non-invasive marker for early diagnosis of biliary atresia (BA) and selection of BA patients indicated for Kasai portoenterostomy. Material and methods: The study included 60 infants with neonatal cholestasis in three groups; early BA group ( n = 20), delayed BA group ( n = 20) and non-BA cholestasis group ( n = 20). A fourth group of 20 healthy neonates ( n = 20) served as controls...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29903787/quality-of-health-literacy-instruments-used-in-children-and-adolescents-a-systematic-review
#2
Shuaijun Guo, Rebecca Armstrong, Elizabeth Waters, Thirunavukkarasu Sathish, Sheikh M Alif, Geoffrey R Browne, Xiaoming Yu
OBJECTIVE: Improving health literacy at an early age is crucial to personal health and development. Although health literacy in children and adolescents has gained momentum in the past decade, it remains an under-researched area, particularly health literacy measurement. This study aimed to examine the quality of health literacy instruments used in children and adolescents and to identify the best instrument for field use. DESIGN: Systematic review. SETTING: A wide range of settings including schools, clinics and communities...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29886299/a-study-on-the-length-of-lumbar-interbody-cage-using-radiological-measurements-of-chinese-endplates-and-the-apophyseal-ring
#3
Chi Sun, Hongli Wang, Jianyuan Jiang, Feizhou Lu, Xiaosheng Ma, Xinlei Xia
OBJECTIVE: To radiologically measure the parameters of endplates and the apophyseal ring and suggest an applicable length for a lumbar interbody cage for Chinese patients. METHODS: Twenty-four volunteers were enrolled to receive lumbar CT. On the endplate plane, the diameters of the endplates (L1-S1) were measured along the axis of the cage with different lumbar interbody fusion procedures. While mid-OD and max-OD were defined as the minimal and maximal diameters of the endplates in TLIF, side-SD, mid-SD and TD represented the diameters of endplates in PLIF, ALIF and OLIF/XLIF/DLIF, respectively...
June 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29786774/computational-fluid-dynamics-modeling-of-the-human-pulmonary-arteries-with-experimental-validation
#4
Alifer D Bordones, Matthew Leroux, Vitaly O Kheyfets, Yu-An Wu, Chia-Yuan Chen, Ender A Finol
Pulmonary hypertension (PH) is a chronic progressive disease characterized by elevated pulmonary arterial pressure, caused by an increase in pulmonary arterial impedance. Computational fluid dynamics (CFD) can be used to identify metrics representative of the stage of PH disease. However, experimental validation of CFD models is often not pursued due to the geometric complexity of the model or uncertainties in the reproduction of the required flow conditions. The goal of this work is to validate experimentally a CFD model of a pulmonary artery phantom using a particle image velocimetry (PIV) technique...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29766939/minimally-invasive-options-for-surgical-management-of-adjacent-segment-disease-of-the-lumbar-spine
#5
Mazda K Turel, Mena G Kerolus, Brian T David, Richard G Fessler
Background: The incidence of adjacent segment disease (ASD) after lumbar spine surgery is a condition that has become increasingly common as the rate of lumbar spine surgery continues to rise. Minimally invasive techniques continue to be refined and offer an opportunity to treat ASD with minimal tissue disruption, lower blood loss, a shorter hospital stay, and decreased morbidity. The aim of this report is to describe the various minimally invasive options for ASD with a comprehensive review of the existing literature...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29746966/a-systematic-review-of-clinical-outcomes-in-surgical-treatment-of-adult-isthmic-spondylolisthesis
#6
REVIEW
Shaya Noorian, Karen Sorensen, Woojin Cho
BACKGROUND CONTEXT: A variety of surgical methods are available for the treatment of adult isthmic spondylolisthesis, but there is no consensus regarding their relative effects on clinical outcomes. PURPOSE: To compare the effects of different surgical techniques on clinical outcomes in adult isthmic spondylolisthesis. DESIGN: Systematic Review PATIENT SAMPLE: A total of 1,538 patients from six randomized clinical trials and nine observational studies comparing different surgical treatments in adult isthmic spondylolisthesis...
May 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29732435/rational-decision-making-in-a-wide-scenario-of-different-minimally-invasive-lumbar-interbody-fusion-approaches-and-devices
#7
REVIEW
Luiz Pimenta, Antoine Tohmeh, David Jones, Rodrigo Amaral, Luis Marchi, Leonardo Oliveira, Bruce C Pittman, Hyun Bae
With the proliferation of a variety of modern MIS spine surgery procedures, it is mandatory that the surgeon dominate all aspects involved in surgical indication. The information related to the decision making in patient selection for specific procedures is mandatory for surgical success. The objective of this study is to present decision-making criteria in minimally invasive surgery (MIS) selection for a variety of patients and pathologies. In this article, practicing surgeons who specialize in various MIS approaches for spinal fusion were engaged to provide expert opinion and literature review on decision making criteria for several MIS procedures...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29732419/complications-following-single-level-interbody-fusion-procedures-an-acs-nsqip-study
#8
Jamal N Shillingford, Joseph L Laratta, Joseph M Lombardi, John D Mueller, Meghan Cerpa, Hemant P Reddy, Comron Saifi, Charla R Fischer, Ronald A Lehman
Background: Controversy exists over the ability of various lumbar interbody fusion techniques to realign global and regional balance and their effect on patient outcomes. This is a retrospective cohort study to compare thirty-day postoperative outcomes between anterior and posterior interbody fusion techniques within a large national database. Methods: A retrospective cohort study utilizing the National Surgical Quality Improvement Program (NSQIP) database included 2,372 (29...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29707553/minimally-invasive-anterior-lateral-and-oblique-lumbar-interbody-fusion-a-literature-review
#9
REVIEW
David S Xu, Corey T Walker, Jakub Godzik, Jay D Turner, William Smith, Juan S Uribe
Lumbar interbody fusion involves insertion of a structural graft into an intervertebral disc space to promote bony arthrodesis. It is a well-established surgical strategy for multiple spinal disorders ranging from degenerative conditions to trauma, neoplastic diseases, and deformities requiring correction. Since the inception of lumbar interbody fusion, the most established techniques have been two posterior approaches, the posterior lumbar interbody fusion (PLIF) and the transforaminal lumbar interbody fusion (TLIF)...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29664345/a-micro-level-data-calibrated-agent-based-model-the-synergy-between-microsimulation-and-agent-based-modeling
#10
Karandeep Singh, Chang-Won Ahn, Euihyun Paik, Jang Won Bae, Chun-Hee Lee
Artificial life (ALife) examines systems related to natural life, its processes, and its evolution, using simulations with computer models, robotics, and biochemistry. In this article, we focus on the computer modeling, or "soft," aspects of ALife and prepare a framework for scientists and modelers to be able to support such experiments. The framework is designed and built to be a parallel as well as distributed agent-based modeling environment, and does not require end users to have expertise in parallel or distributed computing...
2018: Artificial Life
https://www.readbyqxmd.com/read/29662743/trends-analysis-of-rhbmp2-utilization-in-single-level-anterior-lumbar-interbody-fusion-in-the-united-states
#11
Lifeng Lao, Jeremiah R Cohen, Zorica Buser, Darrel S Brodke, S Tim Yoon, Jim A Youssef, Jong-Beom Park, Hans-Joerg Meisel, Jeffrey C Wang
Study Design: Retrospective case study. Objective: To evaluate the trends and demographics of recombinant human bone morphogenetic protein 2 (rhBMP2) utilization in single-level anterior lumbar interbody fusion (ALIF) in the United States. Methods: Patients who underwent single-level ALIF from 2005 to 2011 were identified by searching ICD-9 diagnosis and procedure codes in the PearlDiver Patient Records Database (PearlDiver Technologies, Fort Wayne, IN), a national database of orthopedic insurance records...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29594193/expression-of-intrahepatic-cd3-cd4-and-cd8-t-cells-in-biliary-atresia
#12
Behairy E Behairy, Nermine Ehsan, Magdy Anwer, Alif Allam, Ibramem El-Henawy, Nesreen Abdel Hameed, Haidy M Zakaria
Aim of the study: Assessment of the expression of cluster of differentiation (CD)3, CD4, and CD8 T cells in biliary atresia (BA) cases in comparison to neonatal cholestasis other than BA. Material and methods: This study included 79 patients: 34 patients with BA (BA group) and 35 patients with neonatal cholestasis due to causes other than BA (cholestasis group), and 10 normal liver donor as a control group. Immunohistochemical staining or CD3, CD4, and CD8 T cells in liver tissues for the 3 groups were evaluated...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29588241/facet-joint-fixation-and-anterior-direct-lateral-and-transforaminal-lumbar-interbody-fusions-for-treatment-of-degenerative-lumbar-disc-diseases-retrospective-cohort-study-of-a-new-minimally-invasive-technique
#13
Evgenii Belykh, Andrey A Kalinin, Nikolay L Martirosyan, Talgat Kerimbayev, Nicholas Theodore, Mark C Preul, Vadim A Byvaltsev
BACKGROUND: Anterior, direct lateral, and transforaminal lumbar interbody fusions (ALIF, DLIF, and TLIF) are usually combined with posterior fixation to treat degenerative spinal diseases. Outcomes of ALIF, TLIF, or DLIF combined with a new wedge-shaped interfacet cage plate have not been reported. We assessed early clinical outcomes of patients treated with interbody fusion and facet fixation using a titanium wedge-shaped cage plate. METHODS: This retrospective observational cohort study included patients (n = 80) who underwent 1-level interbody fusion and facet joint fixation via ALIF (n = 24) or DLIF (n = 26) with bilateral facet fixation or TLIF with ipsilateral pedicle screws and contralateral facet fixation (n = 30)...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29529003/selective-anterior-lumbar-interbody-fusion-for-low-back-pain-associated-with-degenerative-disc-disease-versus-nonsurgical-management
#14
John P Kleimeyer, Ivan Cheng, Todd F Alamin, Serena S Hu, Thomas Cha, Vijay Yanamadala, Kirkham B Wood
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To evaluate the long-term outcomes of selective one- to two-level anterior lumbar interbody fusions (ALIFs) in the lower lumbar spine versus continued nonsurgical management. SUMMARY OF BACKGROUND DATA: Low back pain associated with lumbar intervertebral disc degeneration is common with substantial economic impact, yet treatment remains controversial. Surgical fusion has previously provided mixed results with limited durable improvement of pain and function...
March 9, 2018: Spine
https://www.readbyqxmd.com/read/29508007/-complications-of-the-lumbosacral-junction-in-adult-deformity-surgery-indications-and-technique-for-posterior-and-anterior-revision-surgery
#15
REVIEW
A Tateen, J Bogert, H Koller, A Hempfing
BACKGROUND: Surgical correction of ASD can be challenging. The indication for surgery is individual and after specification of the therapeutic goals, detailed planning of the surgery is essential to achieve a good postoperative result. COMPLICATIONS AND INDICATION: The reasons for the comparatively high complication rate are well investigated and are often located at the lumbosacral junction. In addition to negative general factors like osteoporosis, especially undercorrection of the sagittal profile and insufficient lumbo-pelvic stabilization are causative...
April 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29505978/clinical-and-radiological-outcomes-after-stand-alone-alif-for-single-l5-s1-degenerative-discopathy-using-a-peek-cage-filled-with-hydroxyapatite-nanoparticles-without-bone-graft
#16
Gilles Norotte, Carlos Barrios
OBJECTIVE: Recent improvements in cage designs with integral fixation and screw attachments have made stand-alone ALIF a viable option with several possible advantages. The aim of this study was to confirm the efficacy and safety of a PEEK cage filled with hydroxyapatite nanoparticles without adding a bone graft for stand-alone ALIF in the treatment of L5-S1 isolated degenerative disc discopathy (DDD). PATIENTS AND METHODS: Sixty-five patients who required surgery for DDD were evaluated...
May 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29492369/two-year-outcomes-from-a-single-surgeon-s-learning-curve-experience-of-oblique-lateral-interbody-fusion-without-intraoperative-neuromonitoring
#17
Kamal Woods, Ahtziri Fonseca, Larry E Miller
Introduction Oblique lumbar interbody fusion (OLIF) is a newer procedure that avoids the psoas and lumbosacral plexus due to its oblique trajectory into the retroperitoneal space. While early experience with OLIF is reassuring, the longer-term clinical efficacy has not been well established. The purpose of this study was to describe two-year clinical outcomes with OLIF performed by a single surgeon during the learning curve without the aid of the neuromonitoring. Materials and methods Chart review was performed for the consecutive patients who underwent OLIF by a single surgeon...
December 22, 2017: Curēus
https://www.readbyqxmd.com/read/29463273/outcomes-of-oblique-lateral-interbody-fusion-for-degenerative-lumbar-disease-in-patients-under-or-over-65-years-of-age
#18
Chengzhen Jin, Milin S Jaiswal, Sin-Soo Jeun, Kyeong-Sik Ryu, Jung-Woo Hur, Jin-Sung Kim
BACKGROUND: Oblique lateral interbody fusion (OLIF) offers the solution to problems of anterior lumbar interbody fusion (ALIF) and lateral lumbar interbody fusion (LLIF). However, OLIF technique for degenerative spinal diseases of elderly patients has been rarely reported. The objective of this study was to determine the clinical and radiological results of OLIF technique for degenerative spinal diseases in patients under or over 65 years of age. METHODS: Sixty-three patients who underwent OLIF procedure were enrolled, including 29 patients who were less than 65 years of age and 34 patients who were over 65 years of age...
February 20, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29454985/a-non-toxic-microbial-surfactant-from-marinobacter-hydrocarbonoclasticus-sdk644-for-crude-oil-solubilization-enhancement
#19
Billal Zenati, Alif Chebbi, Abdelmalek Badis, Kamel Eddouaouda, Hocine Boutoumi, Mohamed El Hattab, Dorra Hentati, Manel Chelbi, Sami Sayadi, Mohamed Chamkha, Andrea Franzetti
This study aims to investigate the ability of a biosurfactant produced by Marinobacter hydrocarbonoclasticus strain SdK644 isolated from hydrocarbon contaminated sediment to enhance the solubilization rate of crude oil contaminated seawater. Phylogenetic analysis shows that strain SdK644 was very closely related to M. hydrocarbonoclasticus with 16S rRNA gene sequence similarity of 97.44%. Using waste frying oil as inducer carbon source, the producing biosurfactant by strain SdK644 was applied to improve crude oil solubilization in seawater...
June 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29415435/review-of-current-cell-penetrating-antibody-developments-for-hiv-1-therapy
#20
REVIEW
Muhamad Alif Che Nordin, Sin-Yeang Teow
The discovery of highly active antiretroviral therapy (HAART) in 1996 has significantly reduced the global mortality and morbidity caused by the acquired immunodeficiency syndrome (AIDS). However, the therapeutic strategy of HAART that targets multiple viral proteins may render off-target toxicity and more importantly results in drug-resistant escape mutants. These have been the main challenges for HAART and refinement of this therapeutic strategy is urgently needed. Antibody-mediated treatments are emerging therapeutic modalities for various diseases...
February 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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