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K B Sánchez-Huerta, S Montes, F Pérez-Severiano, C Alva-Sánchez, C Ríos, J Pacheco-Rosado
Thyroid hormones modulate the physiology of the hippocampus in humans, where glutamate plays an important role as neurotransmitter. The aim of this work was to study the effect of hypothyroidism on hippocampal glutamate extracellular levels, release, uptake, and synthesis. The effects of PDC (a glutamate transporter inhibitor) and ouabain (a Na(+) /K(+) -ATPase inhibitor) infusion on microdialysate glutamate and aspartate levels of CA3 hippocampal region were evaluated. Animals were assigned to one of the following groups: hypothyroid group (Hyp), receiving methimazole (anantithyroid drug); replacement group (Hyp + T(4) ), receiving antithyroid treatment plus thyroxine; and euthyroid control group (Eut)...
April 2012: Journal of Neuroscience Research
Juana B Romero, Gerardo C Palacios, Noemí Gómez, Amalia Silva, José H Fabela
BACKGROUND: In Mexico, the congenital hypothyroidism (CH) is a public health problem that has a national incidence ranging from 1:1951 to 1:2458 live births. It is the main endocrine cause of mental retardation. The objective was to evaluate the intelligence coefficient (IQ) of patients with CH using the Wechsler Scale (WS) and to correlate the degree of involvement with its etiology. METHODS: We included patients with CH diagnosed by neonatal screening and treated by who attended the test of Wechsler...
March 2011: Revista Médica del Instituto Mexicano del Seguro Social
José María Martínez Jabaloyas
The proper function of erection mechanisms depend on correct interrelationship between psychological, vascular, neurological and hormonal factors. Endocrine diseases affect sexual function, and sexual dysfunction may be one of the symptoms of some hormonal anomalies. Diabetes mellitus is the endocrine disease most frequently causing erectile dysfunction due to the frequent vascular and neurological complications associated. It is important to determine blood glucose in the initial evaluation of a male with erectile dysfunction, as well as to try an adequate control of blood glucose levels to avoid worsening...
October 2010: Archivos Españoles de Urología
E Arioglu, S Guner, I Ozakca, V M Altan, A T Ozcelikay
Thyroid hormone deficiency has been reported to decrease expression and function of both beta(1)- and beta(2)-adrenoceptor in different tissues including heart. The purpose of this study was to examine the possible contribution of beta(3)-adrenoceptors to cardiac dysfunction in hypothyroidism. In addition, effect of this pathology on beta(1)- and beta(2)-adrenoceptor was investigated. Hypothyroidism was induced by adding methimazole (300 mg/l) to drinking water of rats for 8 weeks. Cardiac hemodynamic parameters were measured in anesthetised rats in vivo...
February 2010: Molecular and Cellular Biochemistry
Christel Jublanc, Eric Bruckert
Hypothyroidism is a common condition and recent epidemiological studies demonstrated that up to 10 percent of subjects may display its subclinical form. Despite the well-known relationship between overt hypothyroidism and cardiovascular disease, few studies demonstrating such a link are available. However, the relationship between hypothyroidism and a variety of cardiovascular risk factors is now well established. Recent data on new cardiovascular risk factors that were shown to be associated with hypotyroidism are reviewed...
May 2004: Seminars in Vascular Medicine
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