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https://www.readbyqxmd.com/read/28088384/the-signalling-mechanisms-of-a-novel-mitochondrial-complex-i-inhibitor-prevent-lipid-accumulation-and-attenuate-tnf-%C3%AE-induced-insulin-resistance-in-vitro
#1
Siobhán Leonard, Laura M Tobin, John B C Findlay
RTC-1 has recently been identified as a member of a new class of anti-diabetic compounds acting through the inhibition of complex I of the mitochondrial respiratory chain (NADH:ubiquinone oxidoreductase) to improve glucose handling and inhibit weight gain in mice fed a high-fat diet (HFD). The exact mechanism by which the reduced activity of NADH:ubiquinone oxidoreductase, in response to RTC-1, promotes these improved metabolic parameters remains to be established. Through extensive in vitro analysis, new molecular insights into these downstream signalling pathways have been obtained...
January 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28057861/cellular-context-dependent-consequences-of-apc-mutations-on-gene-regulation-and-cellular-behavior
#2
Kyoichi Hashimoto, Yosuke Yamada, Katsunori Semi, Masaki Yagi, Akito Tanaka, Fumiaki Itakura, Hitomi Aoki, Takahiro Kunisada, Knut Woltjen, Hironori Haga, Yoshiharu Sakai, Takuya Yamamoto, Yasuhiro Yamada
The spectrum of genetic mutations differs among cancers in different organs, implying a cellular context-dependent effect for genetic aberrations. However, the extent to which the cellular context affects the consequences of oncogenic mutations remains to be fully elucidated. We reprogrammed colon tumor cells in an Apc(Min/+) (adenomatous polyposis coli) mouse model, in which the loss of the Apc gene plays a critical role in tumor development and subsequently, established reprogrammed tumor cells (RTCs) that exhibit pluripotent stem cell (PSC)-like signatures of gene expression...
January 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28007445/functional-goals-and-predictors-of-their-attainment-in-low-income-community-dwelling-older-adults
#3
Brian W Waldersen, Jennifer L Wolff, Laken Roberts, Allysin E Bridges, Laura N Gitlin, Sarah L Szanton
OBJECTIVE: To describe functional goals and factors associated with goal attainment among low-income older adults with disabilities living in the community. DESIGN: Secondary analysis from two studies of CAPABLE. Functional goals were coded using the International Classification of Functioning, Disability, and Health (ICF) framework. The percentage of goals attained at five months follow-up was computed within each ICF domain. Multivariate logistic regression was used to identify factors associated with goal attainment...
December 19, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28006779/cardiorenal-syndrome-type-5-in-sepsis-role-of-endotoxin-in-cell-death-pathways-and-inflammation
#4
Grazia Maria Virzì, Anna Clementi, Alessandra Brocca, Massimo de Cal, Stefano Marcante, Claudio Ronco
BACKGROUND/AIMS: Cardiorenal Syndrome Type 5 (CRS Type 5) is characterized by concomitant cardiac and renal dysfunction in the setting of different systemic disorders, such as sepsis. In this study, we investigated the possible relationship between endotoxin levels, renal cell death and inflammation in septic patients with CRS Type 5. METHODS: We enrolled 11 patients with CRS Type 5. CRS Type 5 was defined according to the current classification system. AKI was defined by Acute Kidney Injury Network (AKIN) criteria...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27991743/vector-synthesis-high-resolution-electrocardiography-atrial-natriuretic-peptide-and-n-terminal-prohormone-brain-natriuretic-peptide-for-estimation-of-cardiac-load-in-pregnancy
#5
Shino Tanaka, Rie Oyama, Akimune Fukushima, Akihiko Kikuchi, Toru Sugiyama
AIM: We analyzed atrial natriuretic peptide (ANP), N-terminal pro-brain natriuretic natriuretic peptide (NT-proBNP) and vector synthesis high-resolution electrocardiography (ECG), to estimate cardiac load with circulatory dynamic change from pregnancy through the post-partum period. METHODS: The subjects were singleton pregnant women (n = 19), who were divided into three stages: stage 1, 34-36 weeks of gestation; stage 2, 2-6 post-partum days; and stage 3, 1-3 months after delivery...
December 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27975148/complications-encountered-in-ultrasonography-guided-radiofrequency-ablation-of-benign-thyroid-nodules-and-recurrent-thyroid-cancers
#6
Cherry Kim, Jeong Hyun Lee, Young Jun Choi, Won Bae Kim, Tae Yon Sung, Jung Hwan Baek
OBJECTIVES: To evaluate the complication rates and describe the possible complications of ultrasonography-guided radiofrequency ablation (RFA) of benign thyroid nodules (BTN) and recurrent thyroid cancers (RTC), and to compare the complication rates between BTN and RTC. METHODS: This retrospective study reviewed 875 patients who underwent RFA for BTN (746 patients; 83.5%) or RTC (129 patients; 14.7%). Medical records were reviewed for all types of complications occurring during and after the RFA procedure...
December 14, 2016: European Radiology
https://www.readbyqxmd.com/read/27913799/involvement-of-recipient-transplant-coordinators-in-transplant-outpatient-clinics-in-japan-current-status-and-transplant-physician-s-thoughts-on-follow-up-clinics
#7
Kuniko Hagiwara, Natsuko Seto, Yasuko Shimizu, Shiro Takahara
CONTEXT: Transplant recipients require long-term immunosuppressive therapy, so continued medical follow-up is necessary for long-term survival. OBJECTIVE: To investigate the current role of recipient transplant coordinators (RTCs) in the outpatient care of organ transplant recipients in Japan. METHODS: We sent a questionnaire survey to doctors in transplant facilities affiliated with the Japan Society for Transplantation probing attitudes on the role of RTCs in outpatient clinics...
December 2, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27900565/randomized-double-blind-controlled-clinical-trials-with-herbal-preparations-of-serenoa-repens-fruits-in-treatment-of-lower-urinary-tract-symptoms-an-overview
#8
Rainer C Görne, Tankred Wegener, Olaf Kelber, Björn Feistel, Jürgen Reichling
In this review, results of randomized double-blind controlled clinical trials (RCTs) with extracts of Serenoa repens fruits at a dose of 320 mg/d for the treatment of lower urinary tract symptoms (LUTS) are assessed. Of the RTCs conducted for up to 6 months, a benefit was seen in three of three RTCs with ethanolic, in eight of nine RTCs with hexane, and in one of two RTCs with CO2 extracts. Of the RTCs conducted for more than 6 months, a benefit was seen in two RTCs with hexane and in one RTC with CO2 extracts, whereas one RTC with an ethanolic, two RTCs with hexane, and one RTC with CO2 extracts did not show positive results...
November 29, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27899123/a-functional-magnetic-resonance-imaging-investigation-of-visual-hallucinations-in-the-human-striate-cortex
#9
Hina Abid, Fayyaz Ahmad, Soo Y Lee, Hyun W Park, Dongmi Im, Iftikhar Ahmad, Safee U Chaudhary
PURPOSE: Human beings frequently experience fear, phobia, migraine and hallucinations, however, the cerebral mechanisms underpinning these conditions remain poorly understood. Towards this goal, in this work, we aim to correlate the human ocular perceptions with visual hallucinations, and map them to their cerebral origins. METHODS: An fMRI study was performed to examine the visual cortical areas including the striate, parastriate and peristriate cortex in the occipital lobe of the human brain...
November 29, 2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27894043/treatment-seeking-in-cannabis-dependence-the-role-of-social-cognition
#10
Zoe E Papinczak, Jason P Connor, Gerald F X Feeney, Ross McD Young, Matthew J Gullo
BACKGROUND AND AIMS: Relatively few cannabis dependent individuals seek treatment and little is known about the determinants of treatment seeking. Social Cognitive Theory (SCT) provides a useful framework for examining human behaviour and motivation which may be helpful in explaining treatment seeking. This study examined the differences in cannabis outcome expectancies and cannabis refusal self-efficacy between treatment seekers and non-treatment seekers with cannabis dependence. DESIGN: Non-treatment seekers were referred to an illicit drug diversion program...
January 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27893865/the-decrease-in-traumatic-brain-injury-epidemics-deriving-from-road-traffic-collision-following-strengthened-legislative-measures-in-france
#11
Thomas Lieutaud, Blandine Gadegbeku, Amina Ndiaye, Mireille Chiron, Vivian Viallon
BACKGROUND: Since 2002, France has been strengthening legislation on road traffic. This study is intended to evaluate the changes in Traumatic Brain Injury (TBI) incidence and mortality resulting from Road Traffic Collision (RTC) in the two 6-year periods before and after 2002. METHODS: We used a Registry of all RTC casualties in the Rhône Department of France. Each casualty was coded according to the Abbreviated Injury Scale (AIS). The study describes changes in demographic variables, TBI (AIS ≥ 2) incidence and mortality, other body lesions (AIS ≥ 3) associated with TBI, road user types, seatbelt and helmet wearing...
2016: PloS One
https://www.readbyqxmd.com/read/27886317/nanoscale-thermal-cloaking-in-graphene-via-chemical-functionalization
#12
Zhen-Qiang Ye, Bing-Yang Cao
Macro-thermal cloaking is typically produced by coordinate transformations, but this method is unsuitable for nanostructures. We designed a graphene-based nanoscale thermal cloak using a novel mechanism of phonon localization. The nanocloak in graphene was produced via the chemical functionalization of hydrogen, methyl and hydroxyl using molecular dynamics simulations. The cloaking performance was quantified by the ratio of thermal cloaking (RTC). We found that the RTC correlated with the functionalization fraction and it has a local maximum at a certain width, since the heat flux reduction in the exterior and the protected region reversed if the width was excessive...
December 7, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27872611/hypocholesterolemic-and-prebiotic-effects-of-a-whole-grain-oat-based-granola-breakfast-cereal-in-a-cardio-metabolic-at-risk-population
#13
Michael L Connolly, Xenofon Tzounis, Kieran M Tuohy, Julie A Lovegrove
Meta-analyses of randomized controlled trials (RTC) have confirmed the hypocholesterolaemic effect of oats and oat based fibers. However, the mechanisms by which oats or oat fractions lower cholesterol is not totally clear. Recognizing the important role of the gut microbiome in metabolism and metabolic disease risk, we examined the impact of whole grain oat Granola (WGO) on the human gut microbiota and cardio-metabolic risk factors using a randomized crossover dietary intervention in at risk individuals (ClinicalTrials...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27815711/the-rocky-treatment-course-identifying-a-high-risk-subgroup-of-head-and-neck-cancer-patients-for-supportive-interventions
#14
Horia Vulpe, Janet Ellis, Shao Hui Huang, Eshetu G Atenafu, Raymond W Jang, Gary Rodin, Jolie Ringash
PURPOSE: We aim to identify the risk factors for a "rocky" treatment course (RTC) in head and neck cancer. METHODS: A retrospective case-control study was conducted utilizing data from a prospective study. We defined the RTC as a composite of adverse outcomes including G-tube dependence and increased nursing interventions. Statistically associative variables were included in a multivariable logistic regression. We also evaluated whether the RTC, or its components, associated with worse cancer outcomes...
November 4, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27812072/descriptive-epidemiology-of-karachi-road-traffic-crash-mortality-from-2007-to-2014
#15
Rashid Jooma, Masood Ali Shaikh
According to World Health Organization's estimate for Pakistan, there were 25,781 (95% CI: 20,979-30582) Road Traffic Collision (RTC) fatalities in year 2013. The Road Traffic Injury Research and Prevention Center, collects RTC data on injuries and fatalities from five major public and private hospitals' emergency departments in Karachi. For the eight-year period, from 2007-2014, 9129 fatalities were recorded. Males accounted for 8008 (87.7%) all RTC fatalities. Highest number of fatalities were recorded in the 21-25 age group with 1329 (15...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27807523/effect-of-concurrent-resistance-and-sprint-training-on-body-composition-and-cardiometabolic-health-indicators-in-masters-cyclists
#16
Luke Delvecchio, Peter Reaburn, Gail Trapp, Marko T Korhonen
In older previously sedentary individuals endurance training imposes a more effective stimulus to enhance cardiometabolic health compared with resistance or sprint training. We examined the effect of replacing a portion of endurance training with combined resistance and/or sprint training and how this influences cardiometabolic health indicators in masters endurance cyclists. Twenty-seven well-trained male road cyclists (53.7±8.2 years) were allocated to a resistance and track sprint-cycling training group (RTC, n=10), an endurance and track sprint-cycling group (ETC, n=7) or a control endurance group (CTRL, n=10)...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27759936/mass-spectrometric-analysis-of-synaptosomal-membrane-preparations-for-the-determination-of-brain-receptors-transporters-and-channels
#17
Fernando J Sialana, Peter Gulyassy, Peter Májek, Evelina Sjöstedt, Viktor Kis, André C Müller, Elena L Rudashevskaya, Jan Mulder, Keiryn L Bennett, Gert Lubec
The molecular composition of synaptic signal transduction machineries shapes synaptic neurotransmission. The repertoire of receptors, transporters and channels (RTCs) comprises major signaling events in the brain. RTCs are conventionally studied by candidate immunohistochemistry and biochemistry, which are low throughput with resolution greatly affected by available immunoreagents and membrane interference. Therefore, a comprehensive resource of synaptic brain RTCs is still lacking. In particular, studies on the detergent-soluble synaptosomal fraction, known to contain transporters and channels, are limited...
October 19, 2016: Proteomics
https://www.readbyqxmd.com/read/27755515/ecg-pattern-in-reverse-takotsubo-cardiomyopathy-demonstrated-in-5-cases-with-intracranial-hemorrhage
#18
Waldemar Elikowski, Małgorzata Małek-Elikowska, Bartosz Kudliński, Paweł Skrzywanek, Sławomir Smól, Stanisław Rzymski
In typical takotsubo cardiomyopathy (TC) apical transient left ventricular dysfunction with concomitant ECG changes mimicking acute anterior myocardial infarction can be observed. Reverse TC (RTC) characterized by contractile disturbances in all basal and often simultaneous mid-ventricular segments is definitely less frequent. ECG pattern of RTC is less known. The authors present ECG findings in 5 cases of RTC in course of intracranial hemorrhage (ICH); 3 patients were diagnosed with subarachnoid hemorrhage (SAH) and the other two with intracerebral hemorrhage or subdural posttraumatic hematoma...
September 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27736679/prevalence-of-driving-under-the-influence-of-psychoactive-substances-and-road-traffic-crashes-among-brazilian-crack-using-drivers
#19
Juliana Nichterwitz Scherer, Roberta Silvestrin, Felipe Ornell, Vinícius Roglio, Tanara Rosangela Vieira Sousa
BACKGROUND: Substance use disorders are associated with the increased risk of driving under the influence (DUI), but little is known about crack-cocaine and its relationship with road traffic crashes (RTC). METHOD: A multicenter sample of 765 crack-cocaine users was recruited in six Brazilian capitals in order to estimate the prevalence of DUI and RTC involvement. Legal, psychiatric, and drug-use aspects related with traffic safety were evaluated using the Addiction Severity Index - 6th version (ASI-6) and the Mini International Neuropsychiatric Interview...
October 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27719634/outcomes-with-dronedarone-in-atrial-fibrillation-what-differences-between-real-world-practice-and-trials-a-meta-analysis-and-meta-regression-analysis
#20
Igor Diemberger, Giulia Massaro, Maria Letizia Bacchi Reggiani, Stefano Lorenzetti, Mauro Biffi, Matteo Ziacchi, Cristian Martignani, Giuseppe Boriani
Dronedarone was found to have divergent safety profiles in randomized controlled trials (RCT) in term of cardiac death and overall mortality. We decided to evaluate all available evidence on the cardiovascular safety of this drug. A systematic search was made of the MEDLINE and the Cochrane Central Register of Controlled Trials from January 2003 through April 2016 for RCT comparing dronedarone to placebo/active control, to provide the most accurate estimate of the effects of this agent and observational cohort studies (OBS) reporting clinical outcomes in patients treated with dronedarone, according to current guidelines, to obtain a real-life comparator for the findings summarized by RTC analysis...
October 6, 2016: Current Pharmaceutical Design
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