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https://www.readbyqxmd.com/read/29121906/impaired-contractile-function-of-the-supraspinatus-in-the-acute-period-following-a-rotator-cuff-tear
#1
Ana P Valencia, Shama R Iyer, Espen E Spangenburg, Mohit N Gilotra, Richard M Lovering
BACKGROUND: Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle. METHODS: Unilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus...
November 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29082638/the-effect-of-changes-in-pain-expectations-on-persistent-pain-following-a-road-traffic-crash
#2
S L Edmed, K M Moss, J Warren, J Kenardy
BACKGROUND: Recovery expectations can influence outcomes after injury, but little is known about the course of expectations over time or factors predicting changes in expectations. This study aimed to describe how expectations of persistent pain change over time following a non-catastrophic injury sustained in a road traffic crash (RTC); identify the early predictors of change in expectations over time; and examine whether change in expectations predicted pain at 24 months post-RTC. METHODS: One hundred and seventy-seven participants (Mage = 49...
October 30, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29062345/distraction-related-road-traffic-collisions
#3
Hani O Eid, Fikri M Abu-Zidan
OBJECTIVES: We aimed to prospectively study distraction-related road traffic collision injuries, their contributory factors, severity, and outcome. METHODS: Data were prospectively collected on all hospitalized road traffic collision trauma patients in Al-Ain City who were drivers at the collision time over one and half years. Driver's inattentive behaviors preceding the collision were collected by interviewing the admitted drivers. RESULTS: There were 444 drivers, 330 of them were fully oriented patients, out of them only 44 (13%) were distracted...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29058715/estimating-the-causal-tissues-for-complex-traits-and-diseases
#4
Halit Ongen, Andrew A Brown, Olivier Delaneau, Nikolaos I Panousis, Alexandra C Nica, Emmanouil T Dermitzakis
How to interpret the biological causes underlying the predisposing markers identified through genome-wide association studies (GWAS) remains an open question. One direct and powerful way to assess the genetic causality behind GWAS is through analysis of expression quantitative trait loci (eQTLs). Here we describe a new approach to estimate the tissues behind the genetic causality of a variety of GWAS traits, using the cis-eQTLs in 44 tissues from the Genotype-Tissue Expression (GTEx) Consortium. We have adapted the regulatory trait concordance (RTC) score to measure the probability of eQTLs being active in multiple tissues and to calculate the probability that a GWAS-associated variant and an eQTL tag the same functional effect...
October 23, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28973641/l-carnitine-via-ppar%C3%AE-and-sirt1-dependent-mechanisms-attenuates-epithelial-mesenchymal-transition-and-renal-fibrosis-caused-by-perfluorooctanesulfonate
#5
Hsiu-Chu Chou, Li-Li Wen, Chih-Cheng Chang, Chien-Yu Lin, Lu Jin, Shu-Hui Juan
We have previously reported that perfluorooctanesulfonate (PFOS) causes cell apoptosis in renal tubular epithelial cells (RTCs). Here, we extend our findings and provide evidence of epithelial-mesenchymal transition (EMT)-associated renal fibrosis caused by PFOS and the protection by L-carnitine. Our results demonstrate that PFOS increased the expression of EMT and renal injury biomarkers (e.g., N-cadherin, vimentin, Snail, Kim1, and Lcn2). Additionally, PFOS caused EMT induction through Sirt1-mediated PPARγ deacetylation and inactivation...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28917316/humoral-and-cytokine-response-elicited-during-immunisation-with-recombinant-immune-mapped-protein-1-etimp-1-and-oocysts-of-eimeria-tenella
#6
Krishnendu Kundu, Rajat Garg, Saroj Kumar, Mrityunjay Mandal, Fiona M Tomley, Damer P Blake, Partha Sarathi Banerjee
Eimeria tenella, the causative agent of caecal coccidiosis, is a pathogenic gut dwelling protozoan which can cause severe morbidity and mortality in farmed chickens. Immune mapped protein-1 (IMP-1) has been identified as an anticoccidial vaccine candidate; in the present study allelic polymorphism was assessed across the IMP-1 coding sequence in E. tenella isolates from four countries and compared with the UK reference Houghton strain. Nucleotide diversity was low, limited to expansion/contraction of a CAG triplet repeat and five substitutions, three of which were non-synonymous...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28915305/trauma-epidemiology-of-women-in-puerto-rico-2002-2011
#7
Sofía Muns-Aponte, Omar García-Rodríguez, Ediel O Ramos-Meléndez, Pablo Rodríguez-Ortiz
OBJECTIVE: Recent literature has suggested that trauma is heterogenic and that physiological response to it differs between sexes. The study represented in this manuscript aimed to describe gender differences in the mortality rates of trauma patients at the Puerto Rico Trauma Hospital (PRTH). MATERIALS AND METHODS: This was a cross-sectional study performed at PRTH. A total of 14,874 injured patients admitted to the hospital from 2002 to 2011 were included in the sample and divided into 2 groups, based on sex...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28910684/the-effect-of-ambient-light-condition-on-road-traffic-collisions-involving-pedestrians-on-pedestrian-crossings
#8
Jim Uttley, Steve Fotios
Previous research suggests darkness increases the risk of a collision involving a pedestrian and the severity of any injury suffered. Pedestrian crossings are intended to make it safer to cross the road, but it is not clear whether they are effective at doing this after-dark, compared with during daylight. Biannual clock changes resulting from transitions to and from daylight saving time were used to compare RTCs in the UK during daylight and darkness but at the same time of day, thus controlling for potential influences on RTC numbers not related to the ambient light condition...
November 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28879632/real-time-clustered-multiple-signal-classification-rtc-music
#9
Christoph Dinh, Lorenz Esch, Johannes Rühle, Steffen Bollmann, Daniel Güllmar, Daniel Baumgarten, Matti S Hämäläinen, Jens Haueisen
Magnetoencephalography (MEG) and electroencephalography provide a high temporal resolution, which allows estimation of the detailed time courses of neuronal activity. However, in real-time analysis of these data two major challenges must be handled: the low signal-to-noise ratio (SNR) and the limited time available for computations. In this work, we present real-time clustered multiple signal classification (RTC-MUSIC) a real-time source localization algorithm, which can handle low SNRs and can reduce the computational effort...
September 6, 2017: Brain Topography
https://www.readbyqxmd.com/read/28878073/characterization-of-a-replicating-mammalian-orthoreovirus-with-tetracysteine-tagged-%C3%AE-ns-for-live-cell-visualization-of-viral-factories
#10
Luke D Bussiere, Promisree Choudhury, Bryan Bellaire, Cathy L Miller
Within infected host cells, mammalian orthoreovirus (MRV) forms viral factories (VFs), which are sites of viral transcription, translation, assembly, and replication. The MRV nonstructural protein μNS comprises the structural matrix of VFs and is involved in recruiting other viral proteins to VF structures. Previous attempts have been made to visualize VF dynamics in live cells, but due to current limitations in recovery of replicating reoviruses carrying large fluorescent protein tags, researchers have been unable to directly assess VF dynamics from virus-produced μNS...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28854385/performance-evaluation-of-a-smart-buffer-control-at-a-wastewater-treatment-plant
#11
P van Daal-Rombouts, L Benedetti, J de Jonge, S Weijers, J Langeveld
Real time control (RTC) is increasingly seen as a viable method to optimise the functioning of wastewater systems. Model exercises and case studies reported in literature claim a positive impact of RTC based on results without uncertainty analysis and flawed evaluation periods. This paper describes two integrated RTC strategies at the wastewater treatment plant (WWTP) Eindhoven, the Netherlands, that aim to improve the use of the available tanks at the WWTP and storage in the contributing catchments to reduce the impact on the receiving water...
November 15, 2017: Water Research
https://www.readbyqxmd.com/read/28815336/treatment-selection-in-oropharyngeal-cancer-a-surveillance-epidemiology-and-end-results-seer-patterns-of-care-analysis
#12
Nitin A Pagedar, Catherine Chioreso, Jennifer A Schlichting, Charles F Lynch, Mary E Charlton
PURPOSE: Treatment for oropharyngeal cancer (OPC) has changed over the past two decades under multiple influences. We provide a population-based description of the application of radiotherapy, surgery, and chemotherapy to OPC in 1997, 2004, and 2009. METHODS: The National Cancer Institute's Patterns of Care study for OPC included multiple variables not available in the public-use dataset. We identified factors correlating with selection of primary surgery versus radiotherapy with or without chemotherapy (RTC) and analyzed predictors of all-cause mortality...
October 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28805691/structural-and-neuronal-integrity-measures-of-fatigue-severity-in-multiple-sclerosis
#13
Evanthia Bernitsas, Kalyan Yarraguntla, Fen Bao, Rishi Sood, Carla Santiago-Martinez, Rajkumar Govindan, Omar Khan, Navid Seraji-Bozorgzad
Fatigue is a common and disabling symptom in Multiple Sclerosis (MS). However, consistent neuroimaging correlates of its severity are not fully elucidated. In this article, we study the neuronal correlates of fatigue severity in MS. Forty-three Relapsing Remitting MS (RRMS) patients with MS-related fatigue (Fatigue Severity Scale (FSS) range: 1-7) and Expanded Disability Status Scale (EDSS) ≤ 4, were divided into high fatigue (HF, FSS ≥ 5.1) and low fatigue groups (LF, FSS ≤ 3). We measured T2 lesion load using a semi-automated technique...
August 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28783322/cost-effective-river-water-quality-management-using-integrated-real-time-control-technology
#14
Fanlin Meng, Guangtao Fu, David Butler
Integrated real-time control (RTC) of urban wastewater systems is increasingly presented as a promising and emerging strategy to deliver improved surface water quality by responsive operation according to real-time data collected from the sewer system, treatment plant, and the receiving water. However, the detailed benefits and costs associated with integrated RTC have yet to be comprehensively evaluated. Built on state-of-the-art modeling and analytical tools, a three-step framework is proposed to develop integrated RTC strategies which cost-effectively maximize environmental outcomes...
August 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28776030/urbanization-induced-population-migration-has-reduced-ambient-pm2-5-concentrations-in-china
#15
Huizhong Shen, Shu Tao, Yilin Chen, Philippe Ciais, Burak Güneralp, Muye Ru, Qirui Zhong, Xiao Yun, Xi Zhu, Tianbo Huang, Wei Tao, Yuanchen Chen, Bengang Li, Xilong Wang, Wenxin Liu, Junfeng Liu, Shuqing Zhao
Direct residential and transportation energy consumption (RTC) contributes significantly to ambient fine particulate matter with a diameter smaller than 2.5 μm (PM2.5) in China. During massive rural-urban migration, population and pollutant emissions from RTC have evolved in terms of magnitude and geographic distribution, which was thought to worsen PM2.5 levels in cities but has not been quantitatively addressed. We quantify the temporal trends and spatial patterns of migration to cities and evaluate their associated pollutant emissions from RTC and subsequent health impact from 1980 to 2030...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28759601/prevalence-of-toxocara-species-infection-in-the-u-s-results-from-the-national-health-and-nutrition-examination-survey-2011-2014
#16
Aaron Farmer, Thomas Beltran, Young Sammy Choi
Toxocariasis is one of the most common neglected infections of poverty in the U.S. with a reported National Health and Nutrition Examination Survey (NHANES) III (1988-1994) seroprevalence of 13.9% based on enzyme immunoassay testing. We reviewed NHANES data from 2011-2014 to assess current levels. Sera collected from NHANES 2011-2014 participants six years and older were tested for exposure using rTc-CTL-1 antigen, a more sensitive and specific recombinant antigen for IgG antibodies for Toxocara spp. These results were subdivided into children (age 6-17) and adults (age ≥ 18) and then compared between various sociodemographic characteristics...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28728061/qualifying-information-on-deaths-and-serious-injuries-caused-by-road-traffic-in-five-brazilian-capitals-using-record-linkage
#17
Polyana Maria Pimenta Mandacaru, Ana Lucia Andrade, Marli Souza Rocha, Fernanda Pinheiro Aguiar, Maria Sueli M Nogueira, Anne Marielle Girodo, Ana Amélia Galas Pedrosa, Vera Lídia Alves de Oliveira, Marta Maria Malheiros Alves, Lúcia Maria Miana M Paixão, Deborah Carvalho Malta, Marta Maria Alves Silva, Otaliba Libanio de Morais Neto
INTRODUCTION: Road traffic crashes (RTC) are an important public health problem, accounting for 1.2 million deaths per year worldwide. In Brazil, approximately 40,000 deaths caused by RTC occur every year, with different trends in the Federal Units. However, these figures may be even greater if health databases are linked to police records. In addition, the linkage procedure would make it possible to qualify information from the health and police databases, improving the quality of the data regarding underlying cause of death, cause of injury in hospital records, and injury severity...
July 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28690892/outcomes-of-multi-trauma-road-traffic-crashes-at-a-tertiary-hospital-in-oman-does-attendance-by-trauma-surgeons-versus-non-trauma-surgeons-make-a-difference
#18
Ammar Al-Kashmiri, Sultan Z Al-Shaqsi, Nada Al-Marhoobi, Mahmood Hasan
OBJECTIVES: Trauma surgeons are essential in hospital-based trauma care systems. However, there are limited data regarding the impact of their presence on the outcome of multi-trauma patients. This study aimed to assess the outcomes of multi-trauma road traffic crash (RTC) cases attended by trauma surgeons versus those attended by non-trauma surgeons at a tertiary hospital in Oman. METHODS: This retrospective study was conducted in December 2015. A previously published cohort of 821 multi-trauma RTC patients admitted between January and December 2011 to the Sultan Qaboos University Hospital, Muscat, Oman, were reviewed for demographic, injury and hospitalisation data...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28690732/maxillofacial-fractures-in-a-budding-teaching-hospital-a-study-of-pattern-of-presentation-and-care
#19
Obitade Sunday Obimakinde, Kolawole Olubunmi Ogundipe, Taopheeq Bamidele Rabiu, Victoria Nwebuni Okoje
INTRODUCTION: Previous reports indicated that there is geographic and sociodemographic variation in the epidemiology of maxillofacial fractures. Audit of maxillofacial injuries managed at any institution is therefore necessary to understand the trends and proffer strategies for prevention. We therefore embarked on this study to determine the pattern of maxillofacial fractures and concomitant injuries in our institution. METHODS: We carried out a retrospective review of information on demography, aetiology and type of maxillofacial fracture, patients' status, type of crash, level of consciousness and concomitant injuries...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28652831/a-study-in-a-hospital-setting-in-trinidad-and-tobago-west-indies-on-the-psychological-factors-that-cause-road-traffic-collisions
#20
Chavin D Gopaul, Aruna Singh-Gopaul, Edison D Haqq
The following research paper aims to examine the psychological factors that have led to road traffic collisions (RTCs) by conducting research on drivers who had been admitted to the Accident and Emergency department at four major hospitals in Trinidad as RTC cases. A cross-sectional survey was conducted in four major hospitals in Trinidad. Sample size was 900 participants admitted to the hospital as RTC cases, and the sample was selected using Daniel's formula. All 900 participants were drivers involved in an RTC and were mostly male, and majority of drivers involved in an RTC were within the age group of 30-39 years...
2017: Psychology Research and Behavior Management
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