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serotonin and accumbens

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https://www.readbyqxmd.com/read/27903793/the-serotonin-5-ht2c-receptor-and-the-non-addictive-nature-of-classic-hallucinogens
#1
REVIEW
Clinton E Canal, Kevin S Murnane
Classic hallucinogens share pharmacology as serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists. Unique among most other Schedule 1 drugs, they are generally non-addictive and can be effective tools in the treatment of addiction. Mechanisms underlying these attributes are largely unknown. However, many preclinical studies show that 5-HT2C agonists counteract the addictive effects of drugs from several classes, suggesting this pharmacological property of classic hallucinogens may be significant. Drawing from a comprehensive analysis of preclinical behavior, neuroanatomy, and neurochemistry studies, this review builds rationale for this hypothesis, and also proposes a testable, neurobiological framework...
November 15, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27888043/infusion-of-fluoxetine-a-serotonin-reuptake-inhibitor-in-the-shell-region-of-the-nucleus-accumbens-increases-blood-glucose-concentrations-in-rats
#2
C Diepenbroek, M Rijnsburger, L Eggels, K M van Megen, M T Ackermans, E Fliers, A Kalsbeek, M J Serlie, S E la Fleur
The brain is well known to regulate blood glucose, and the hypothalamus and hindbrain, in particular, have been studied extensively to understand the underlying mechanisms. Nuclei in these regions respond to alterations in blood glucose concentrations and can alter glucose liver output or glucose tissue uptake to maintain blood glucose concentrations within strict boundaries. Interestingly, several cortico-limbic regions also respond to alterations in glucose concentrations and have been shown to project to hypothalamic nuclei and glucoregulatory organs...
November 22, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27857753/serotonin-regulates-brain-derived-neurotrophic-factor-expression-in-select-brain-regions-during-acute-psychological-stress
#3
De-Guo Jiang, Shi-Li Jin, Gong-Ying Li, Qing-Qing Li, Zhi-Ruo Li, Hong-Xia Ma, Chuan-Jun Zhuo, Rong-Huan Jiang, Min-Jie Ye
Previous studies suggest that serotonin (5-HT) might interact with brain-derived neurotrophic factor (BDNF) during the stress response. However, the relationship between 5-HT and BDNF expression under purely psychological stress is unclear. In this study, one hour before psychological stress exposure, the 5-HT1A receptor agonist 8-OH-DPAT or antagonist MDL73005, or the 5-HT2A receptor agonist DOI or antagonist ketanserin were administered to rats exposed to psychological stress. Immunohistochemistry and in situ hybridization revealed that after psychological stress, with the exception of the ventral tegmental area, BDNF protein and mRNA expression levels were higher in the 5-HT1A and the 5-HT2A receptor agonist groups compared with the solvent control no-stress or psychological stress group in the CA1 and CA3 of the hippocampus, prefrontal cortex, central amygdaloid nucleus, dorsomedial hypothalamic nucleus, dentate gyrus, shell of the nucleus accumbens and the midbrain periaqueductal gray...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27844095/antidepressant-effects-of-combination-of-brexpiprazole-and-fluoxetine-on-depression-like-behavior-and-dendritic-changes-in-mice-after-inflammation
#4
Min Ma, Qian Ren, Chun Yang, Ji-Chun Zhang, Wei Yao, Chao Dong, Yuta Ohgi, Takashi Futamura, Kenji Hashimoto
RATIONALE: Addition of low doses of atypical antipsychotic drugs with selective serotonin reuptake inhibitors (SSRIs) could promote a rapid antidepressant effect in treatment-resistant patients with major depression. Brexpiprazole, a new atypical antipsychotic drug, has been used as adjunctive therapy for the treatment of major depression. OBJECTIVES: The present study was undertaken to examine whether brexpiprazole could augment antidepressant effects of the SSRI fluoxetine in an inflammation model of depression...
November 15, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27824354/serotonergic-modulation-of-waiting-impulsivity-is-mediated-by-the-impulsivity-phenotype-in-humans
#5
S Neufang, A Akhrif, C G Herrmann, C Drepper, G A Homola, J Nowak, J Waider, A G Schmitt, K-P Lesch, M Romanos
In rodents, the five-choice serial reaction time task (5-CSRTT) has been established as a reliable measure of waiting impulsivity being defined as the ability to regulate a response in anticipation of reinforcement. Key brain structures are the nucleus accumbens (NAcc) and prefrontal regions (for example, pre- and infralimbic cortex), which are, together with other transmitters, modulated by serotonin. In this functional magnetic resonance imaging study, we examined 103 healthy males while performing the 5-CSRTT measuring brain activation in humans by means of a paradigm that has been widely applied in rodents...
November 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27821848/depression-like-phenotype-by-deletion-of-%C3%AE-7-nicotinic-acetylcholine-receptor-role-of-bdnf-trkb-in-nucleus-accumbens
#6
Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimoto
The α7 subtype of nicotinic acetylcholine receptor (nAChR) plays a role in the inflammation which is implicated in depression. This study was undertaken to examine the role of α7 nAChR in depression using α7 nAChR knock-out (KO) mice. Serum levels of tumor necrosis factor-α and interlukin-1β in KO mice were higher than wild-type mice, suggesting an inflammatory process in KO mice. α7 nAChR KO mice showed depression-like phenotype. Furthermore, KO mice showed increased brain-derived neurotrophic factor (BDNF) and its receptor TrkB signaling, as well as increased synaptogenesis and spine density in the nucleus accumbens (NAc), although BDNF-TrkB signaling and synaptogenesis were not altered in the prefrontal cortex and hippocampus...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27755991/risperidone-and-escitalopram-co-administration-a-potential-treatment-of-schizophrenia-symptoms-with-less-side-effects
#7
Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Alexandra Jurczak, Anna Górska, Zofia Rogóż, Krystyna Gołembiowska
BACKGROUND: Schizophrenia is a psychiatric disorder characterized by positive and negative symptoms often accompanied by depression and cognitive deficits. Positive symptoms, like delusions and hallucinations are caused by an excess of dopamine (DA) signaling and are treated with the second generation antipsychotic drugs. Negative symptoms of schizophrenia are represented by social withdrawal, apathy and blunted emotional response. It was demonstrated that co-administration of risperidone and selective serotonin reuptake inhibitors alleviated depressive symptoms and cognitive dysfunction in animal models of schizophrenia...
September 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27702628/effects-of-repeated-high-dose-methamphetamine-and-ceftriaxone-post-treatments-on-tissue-content-of-dopamine-and-serotonin-as-well-as-glutamate-and-glutamine
#8
Yusuf S Althobaiti, Atiah H Almalki, Sujan C Das, Fahad S Alshehri, Youssef Sari
Repeated exposure to high doses of methamphetamine (METH) is known to alter several neurotransmitters in certain brain regions. Little is known about the effects of ceftriaxone (CEF), a β-lactam antibiotic, known to upregulate glutamate transporter subtype 1, post-treatment on METH-induced depletion of dopamine and serotonin (5-HT) tissue content in brain reward regions. Moreover, the effects of METH and CEF post-treatment on glutamate and glutamine tissue content are not well understood. In this study, Wistar rats were used to investigate the effects of METH and CEF post-treatment on tissue content of dopamine/5-HT and glutamate/glutamine in the nucleus accumbens (NAc) and prefrontal cortex (PFC)...
October 1, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27646482/evidence-that-activation-of-nuclear-peroxisome-proliferator-activated-receptor-alpha-ppar%C3%AE-modulates-sleep-homeostasis-in-rats
#9
Eric Murillo-Rodríguez, Khalil Guzmán, Gloria Arankowsky-Sandoval, Mireille Salas-Crisóstomo, Ramsés Jiménez-Moreno, Oscar Arias-Carrión
The peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor superfamily that has been suggested as a modulator of several physiological functions. The PPARα recognizes as an endogenous ligand the anorexic lipid mediator oleoylethanolamide (OEA) which displays wake-inducing properties. Despite that recent evidence indicates that activation of PPARα by synthetic agonists such as Wy14643 enhances waking as well as the extracellular contents of wake-related neurotransmitters, the role of PPARα in sleep recovery after prolonged waking has not been fully described...
September 16, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27569181/regional-specific-modulation-of-neuronal-activation-associated-with-nitric-oxide-synthase-inhibitors-in-an-animal-model-of-antidepressant-activity
#10
Eoin Sherwin, Valentina Gigliucci, Andrew Harkin
OBJECTIVE: The regional specific modulation of neuronal activation following drug administration is of interest to determine brain areas involved in the behavioural effects of experimental test compounds. In the current investigation the effects of the L-arginine related NOS inhibitor N(ω)-l-nitroarginine (L-NA) and the structurally unrelated selective neuronal NOS inhibitor 1-(2-Trifluoro-methyl-phenyl) imidazole (TRIM) were assessed in the rat for changes in regional c-FOS immunoreactivity, a marker of neuronal activation, upon exposure to the forced swimming test (FST)...
January 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27566488/behavioral-pharmacological-and-neuroanatomical-analysis-of-serotonin-2c-receptor-agonism-on-maternal-behavior-in-rats
#11
Ruiyong Wu, Jun Gao, Shinnyi Chou, Collin Davis, Ming Li
As a highly motivated social behavior, maternal behavior in rats has been routinely used to study psychoactive drugs for clinical, neuroscience and pharmacological purposes. Recent evidence indicates that acute activation of serotonin 2C (5-HT2C) receptors causes a disruption of rat maternal behavior. The present study was designed to elucidate the behavioral, pharmacological mechanisms and neuroanatomical basis of this 5-HT2C effect. First, we replicated the finding that acute MK212 injection (2.0mg/kg, a highly selective 5-HT2C agonist) disrupts maternal behavior, especially on pup retrieval...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27566288/sex-differences-in-abuse-related-neurochemical-and-behavioral-effects-of-3-4-methylenedioxymethamphetamine-mdma-in-rats
#12
M F Lazenka, J A Suyama, C T Bauer, M L Banks, S S Negus
3,4-methylenedioxymethamphetamine (MDMA) is a substrate for the dopamine (DA), norepinephrine and serotonin (5HT) transporters that produces greater pharmacological effects on certain endpoints in females than males in both clinical and rodent preclinical studies. To evaluate potential for sex differences in abuse-related MDMA effects, the present study compared MDMA effects on intracranial self-stimulation (ICSS) and on in vivo microdialysis measurements of DA or 5HT in the nucleus accumbens (NAc) in female and male Sprague-Dawley rats...
August 23, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27485686/neuronal-deletion-of-kmt2a-mll1-histone-methyltransferase-in-ventral-striatum-is-associated-with-defective-spike-timing-dependent-striatal-synaptic-plasticity-altered-response-to-dopaminergic-drugs-and-increased-anxiety
#13
Erica Y Shen, Yan Jiang, Behnam Javidfar, Bibi Kassim, Yong-Hwee E Loh, Qi Ma, Amanda C Mitchell, Venu Pothula, A Francis Stewart, Patricia Ernst, Wei-Dong Yao, Gilles Martin, Li Shen, Mira Jakovcevski, Schahram Akbarian
Lysine (K) methyltransferase 2a (Kmt2a) and other regulators of H3 lysine 4 methylation, a histone modification enriched at promoters and enhancers, are widely expressed throughout the brain, but molecular and cellular phenotypes in subcortical areas remain poorly explored. We report that Kmt2a conditional deletion in postnatal forebrain is associated with excessive nocturnal activity and with absent or blunted responses to stimulant and dopaminergic agonist drugs, in conjunction with near-complete loss of spike-timing-dependent long-term potentiation in medium spiny neurons (MSNs)...
December 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27469513/effects-of-ketamine-and-ketamine-metabolites-on-evoked-striatal-dopamine-release-dopamine-receptors-and-monoamine-transporters
#14
Adem Can, Panos Zanos, Ruin Moaddel, Hye Jin Kang, Katinia S S Dossou, Irving W Wainer, Joseph F Cheer, Douglas O Frost, Xi-Ping Huang, Todd D Gould
Following administration at subanesthetic doses, (R,S)-ketamine (ketamine) induces rapid and robust relief from symptoms of depression in treatment-refractory depressed patients. Previous studies suggest that ketamine's antidepressant properties involve enhancement of dopamine (DA) neurotransmission. Ketamine is rapidly metabolized to (2S,6S)- and (2R,6R)-hydroxynorketamine (HNK), which have antidepressant actions independent of N-methyl-d-aspartate glutamate receptor inhibition. These antidepressant actions of (2S,6S;2R,6R)-HNK, or other metabolites, as well as ketamine's side effects, including abuse potential, may be related to direct effects on components of the dopaminergic (DAergic) system...
October 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27461536/neurotoxic-effects-of-5-meo-dipt-a-psychoactive-tryptamine-derivative-in-rats
#15
Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Grzegorz Kreiner, Zofia Rogóż, Krystyna Gołembiowska
5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT, 'foxy') is one of the most popular tryptamine hallucinogens in the illicit drug market. It produces serious adverse effects, but its pharmacological profile is not well recognized. In vitro data have shown that 5-MeO-DIPT acts as a potent serotonin transporter (SERT) inhibitor and displays high affinity at serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors. In this study, using microdialysis in freely moving rats, we examined the effect of 5-MeO-DIPT on dopamine (DA), serotonin (5-HT), and glutamate release in the rat striatum, nucleus accumbens, and frontal cortex...
November 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27428765/early-antipsychotic-exposure-affects-serotonin-and-dopamine-receptor-binding-density-differently-in-selected-brain-loci-of-male-and-female-juvenile-rats
#16
Jiamei Lian, Bo Pan, Chao Deng
BACKGROUND: Antipsychotic drugs (APDs) were developed to treat schizophrenia in adults; however they have been increasingly prescribed (mostly "off-label") for children and adolescents. This study aimed to investigate the effects of aripiprazole, olanzapine and risperidone on the binding of serotonin (5-HT) and dopamine receptors in juvenile rat brain regions that are involved in antipsychotic efficacy. METHODS: Male and female rats were treated orally with aripiprazole (1mg/kg), olanzapine (1mg/kg), risperidone (0...
October 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27412669/nasal-administration-of-leptin-dose-dependently-increases-dopamine-and-serotonin-outflow-in-the-rat-nucleus-accumbens
#17
Sonya Neto, Ramya Varatharajan, Kevin Joseph, Andreas Moser
Leptin is an anorexigenic hormone that acts via its receptor (LepR) to regulate the hypothalamic arcuate nucleus circuitry to mediate energy homeostasis and feeding behavior. Moreover, leptin decreases the reward value of natural and artificial rewards, and low levels of circulating leptin have been implicated in several mood disorders linking leptin to the mesolimbic system. Therefore, the purpose of this study was to assess whether and to what extent an acute intranasal application of leptin is able to modulate monoamine neurotransmitters in the nucleus accumbens (NAc)...
July 13, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27383157/differences-in-monoamine-oxidase-activity-in-the-brain-of-wistar-and-august-rats-with-high-and-low-locomotor-activity-a-cytochemical-study
#18
A V Sergutina, V I Rakhmanova
Monoamine oxidase activity was quantitatively assessed by cytochemical method in brain structures (layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, hippocampal CA3 field) of rats of August line and Wistar population with high and low locomotor activity in the open fi eld test. Monoamine oxidase activity (substrate tryptamine) predominated in the nucleus accumbens of Wistar rats with high motor activity in comparison with rats with low locomotor activity. In August rats, enzyme activity (substrates tryptamine and serotonin) predominated in the hippocampus of animals with high motor activity...
June 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27367210/testing-different-paradigms-to-optimize-antidepressant-deep-brain-stimulation-in-different-rat-models-of-depression
#19
Julia Rummel, Mareike Voget, Ravit Hadar, Samuel Ewing, Reinhard Sohr, Julia Klein, Alexander Sartorius, Andreas Heinz, Aleksander A Mathé, Barbara Vollmayr, Christine Winter
Deep brain stimulation (DBS) of several targets induces beneficial responses in approximately 60% of patients suffering from treatment-resistant depression (TRD). The remaining 40% indicate that these stimulation sites do not bear therapeutic relevance for all TRD patients and consequently DBS-targets should be selected according to individual symptom profiles. We here used two animal models of depression known to have different genetic backgrounds and behavioral responses: the therapy-responsive Flinders sensitive line (FSL) and the therapy-refractory congenitally learned helpless rats (cLH) to study symptom-specific DBS effects i) of different brain sites ii) at different stimulation parameters, and iii) at different expressions of the disease...
October 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27339616/involvement-of-gabaa-receptors-in-5-ht1a-and-%C3%AF-1-receptor-synergism-on-prefrontal-dopaminergic-transmission-under-circulating-neurosteroid-deficiency
#20
Yukio Ago, Shigeru Hasebe, Naoki Hiramatsu, Kazuya Mori, Yuji Watabe, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda
RATIONALE: We previously reported that the fluvoxamine-induced increase in prefrontal dopamine levels is enhanced by adrenalectomy/castration (which results in circulating neurosteroid deficiency), via combined activation of serotonin1A (5-HT1A) and σ1 receptors. However, the mechanistic details of the interaction between 5-HT1A and σ1 receptors are unknown. OBJECTIVES: Because most neurosteroids have affinity for γ-aminobutyric acid (GABA)A receptors, in the present study, we examined the involvement of GABAA receptors in this process...
September 2016: Psychopharmacology
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