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https://www.readbyqxmd.com/read/29892051/ant1-mutant-mice-bridge-the-mitochondrial-and-serotonergic-dysfunctions-in-bipolar-disorder
#1
Tomoaki M Kato, Mie Kubota-Sakashita, Noriko Fujimori-Tonou, Fumihito Saitow, Satoshi Fuke, Akira Masuda, Shigeyoshi Itohara, Hidenori Suzuki, Tadafumi Kato
Although mitochondrial and serotonergic dysfunctions have been implicated in the etiology of bipolar disorder (BD), the relationship between these unrelated pathways has not been elucidated. A family of BD and chronic progressive external ophthalmoplegia (CPEO) caused by a mutation of the mitochondrial adenine nucleotide translocator 1 (ANT1, SLC25A4) implicated that ANT1 mutations confer a risk of BD. Here, we sequenced ANT1 in 324 probands of NIMH bipolar disorder pedigrees and identified two BD patients carrying heterozygous loss-of-function mutations...
June 11, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29859012/effects-of-cannabidiol-plus-naltrexone-on-motivation-and-ethanol-consumption
#2
Adrián Viudez-Martínez, María S García-Gutiérrez, Ana Isabel Fraguas-Sánchez, Ana Isabel Torres-Suárez, Jorge Manzanares
BACKGROUND AND PURPOSE: The aim of this study was to explore if the administration of naltrexone (NTX) together with cannabidiol (CBD) may improve the efficacy in reducing alcohol consumption and motivation rather than any of the drugs given separately. EXPERIMENTAL APPROACH: The effects of low doses of NTX (0.7 mg/kg; p.o.) and/or CBD (20 mg/kg/day; s.c.) on ethanol consumption and motivation to drink were evaluated in the oral-ethanol self-administration paradigm in C57BL/6 mice...
June 2, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29801770/-consequences-of-the-monoaminergic-systems-cross-talk-in-the-antidepressant-activity
#3
L Tritschler, R Gaillard, A M Gardier, D J David, J-P Guilloux
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressant treatment for treat major depressive disorders. Despite their effectiveness, only 30% of SSRI-treated patients reach remission of depressive symptoms. SSRIs by inhibiting the serotonin transporter present some limits with residual symptoms. Increasing not only serotonin but also norepinephrine and dopamine levels in limbic areas seems to improve remission. Anatomical relationships across serotoninergic, dopaminergic and noradrenergic systems suggest tight reciprocal regulations among them...
May 22, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29782941/dopamine-and-serotonin-metabolism-associated-with-morphine-reward-and-its-inhibition-with-buspirone-a-study-in-the-rat-striatum
#4
Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda Salman
Adaptations within the nucleus accumbens (NAc) and caudate nucleus (CN) dopamine neurotransmission are involved in behavioral sensitization and enhanced incentive motivation towards drug paired stimuli which lead to drug addiction. Serotonin (5-hydroxytryptamine; 5-HT) can modulate dopamine neurotransmission to reduce rewarding effects of drugs of abuse. A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with buspirone. To understand the neurochemical mechanism involved in morphine addiction and its inhibition with buspirone, present study determines the effects of buspirone, morphine and their co-administration on the metabolism of serotonin and dopamine in the NAc and CN...
May 18, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29774428/inter-individual-differences-in-serotonin-and-glutamate-co-transmission-reflect-differentiation-in-context-induced-conditioned-50-khz-usvs-response-after-morphine-withdrawal
#5
Adam Hamed, Miron Bartosz Kursa
A growing body of research provides compelling evidence that in rats 50-kHz USVs are a form of expression of positive emotions. Context-induced 50-kHz USVs emission is variable among rats, indicating individual differences in contextual response bound up with pharmacological reward. The aims of this study were to: extract the most important neurotransmitters related to context-induced conditioned 50-kHz USVs response; find biological basis of existing inter-individual differences in context-induced conditioned 50-kHz USVs response; create a model of all-to-all neurotransmitters correlations...
May 17, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29713996/the-effects-of-exposure-to-mephedrone-during-adolescence-on-brain-neurotransmission-and-neurotoxicity-in-adult-rats
#6
Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Anna Górska, Joanna Rzemieniec, Agnieszka Wnuk, Adam Wojtas, Grzegorz Kreiner, Małgorzata Kajta, Krystyna Gołembiowska
According to the European Drug Report (2016), the use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in the last years. Studies in humans indicate that psychostimulant drug use in adolescence increases risk of drug abuse in adulthood. Mephedrone by its interaction with transporters for dopamine (DAT) and serotonin (SERT) stimulates their release to the synaptic cleft. In animal studies, high repeated doses of mephedrone given to adolescent but not adult mice or rats induced toxic changes in 5-hydroxytryptamine (5-HT) neurons...
April 30, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29703999/amphetamine-maintenance-differentially-modulates-effects-of-cocaine-methylenedioxypyrovalerone-mdpv-and-methamphetamine-on-intracranial-self-stimulation-and-nucleus-accumbens-dopamine-in-rats
#7
Amy R Johnson, Matthew L Banks, Dana E Selley, S Stevens Negus
Amphetamine maintenance is effective clinically to reduce the consumption of the monoamine uptake inhibitor cocaine but not of the monoamine releaser methamphetamine, and its effectiveness in treating the abuse of other psychostimulants is not known. The mechanisms for differential amphetamine-maintenance effectiveness to treat different types of psychostimulant abuse are also not known. Accordingly, the present study compared the effects of amphetamine maintenance on abuse-related behavioral and neurochemical effects of cocaine, methamphetamine, and the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV) in rats...
April 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29624527/dezocine-alleviates-morphine-induced-dependence-in-rats
#8
Fei-Xiang Wu, Hasan Babazada, Hao Gao, Xi-Ping Huang, Chun-Hua Xi, Chun-Hua Chen, Jin Xi, Wei-Feng Yu, Renyu Liu
BACKGROUND: Opioid dependence is a major public health issue without optimal therapeutics. This study investigates the potential therapeutic effect of dezocine, a nonaddictive opioid, in opioid dependence in rat models. METHODS: Dezocine was administered intraperitoneally to a morphine-dependent rat model to investigate its effect on withdrawal and conditioned place preference (CPP). Effect of dezocine on morphine withdrawal syndrome and CPP was analyzed using 2-way analysis of variance (ANOVA) followed by Tukey's post hoc test...
April 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29571967/functional-mechanism-of-asp5736-a-selective-serotonin-5-ht-5a-receptor-antagonist-with-potential-utility-for-the-treatment-of-cognitive-dysfunction-in-schizophrenia
#9
Mayako Yamazaki, Noriyuki Yamamoto, Junko Yarimizu, Mayuko Okabe, Ai Moriyama, Masako Furutani, Monica M Marcus, Torgny H Svensson, Katsuya Harada
The 5-HT5A receptor is arguably the least understood 5-HT receptor. Despite widespread expression in human and rodent brains it lacks specific ligands. Our previous results suggest that 5-HT5A receptor antagonists may be effective against cognitive impairment in schizophrenia. In this study, using behavioral, immunohistochemical, electrophysiological and microdialysis techniques, we examined the mechanism by which ASP5736, a novel and selective 5-HT5A receptor antagonist, exerts a positive effect in animal models of cognitive impairment...
May 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29563235/haloperidol-ameliorates-androgen-induced-behavioral-deficits-in-developing-male-rats
#10
Chunxiao Qi, Xiaoming Ji, Guoliang Zhang, Yunxiao Kang, Yuanxiang Huang, Rui Cui, Shuangcheng Li, Huixian Cui, Geming Shi
The purpose of present study was to infer the potential effects of testosterone increase in some male-based childhood-onset neuropsychiatric disorders, such as Tourette syndrome. Thus, the influence of early postnatal androgen exposure upon the neurobehaviors and its possible neural basis were investigated in the study. Male pup rats received consecutive 14-day testosterone propionate (TP) subcutaneous injection from postnatal day (PND) 7. The TP treatment produced the hyperactive motor behavior and grooming behavior as well as the increased levels of dopamine, tyrosine hydroxylase and dopamine transporter in the mesodopaminergic system and the elevated levels of serotonin in the nucleus accumbens, without affecting the levels of glutamate, γ-aminobutyric acid, norepinephrine and histamine in the caudate putamen and nucleus accumbens of PND21 and PND49 rats...
May 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29499311/auditory-stimulation-by-exposure-to-melodic-music-increases-dopamine-and-serotonin-activities-in-rat-forebrain-areas-linked-to-reward-and-motor-control
#11
Michele M Moraes, Patrícia C R Rabelo, Valéria A Pinto, Washington Pires, Samuel P Wanner, Raphael E Szawka, Danusa D Soares
Listening to melodic music is regarded as a non-pharmacological intervention that ameliorates various disease symptoms, likely by changing the activity of brain monoaminergic systems. Here, we investigated the effects of exposure to melodic music on the concentrations of dopamine (DA), serotonin (5-HT) and their respective metabolites in the caudate-putamen (CPu) and nucleus accumbens (NAcc), areas linked to reward and motor control. Male adult Wistar rats were randomly assigned to a control group or a group exposed to music...
April 23, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29427284/a-single-high-dose-of-methamphetamine-reduces-monoamines-and-impairs-egocentric-and-allocentric-learning-and-memory-in-adult-male-rats
#12
Arnold Gutierrez, Michael T Williams, Charles V Vorhees
Methamphetamine (MA) alters dopamine markers and cognitive function in heavy users. In rodents, there are MA dosing regimens that induce concordant effects using repeated administration at spaced intervals. These regimens are effective but complicate experiments designed to disentangle the effects of the drug on different brain regions in relation to their cognitive effects because of treatment spacing. In an effort to simplify the model, we tested whether a single dose of MA could induce the same monoamine and cognitive effects as multiple, spaced dosing without affecting survival...
April 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29407218/membrane-cholesterol-removal-and-replenishment-affect-rat-and-monkey-brain-monoamine-transporters
#13
Marc Morissette, Nicolas Morin, Claude Rouillard, Thérèse Di Paolo
The dopamine transporter (DAT) is abundantly expressed in the striatum where it removes extracellular dopamine into the cytosol of presynaptic nerve terminals. It is the target of drugs of abuse and antidepressants. There is a loss of the DAT in Parkinson's disease affecting release of levodopa implicated in levodopa-induced dyskinesias. This study investigated the effect of cholesterol on DAT, serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2) in monkey and rat brains in vitro. DAT protein levels measured by Western blot remained unchanged with in vitro methyl-β-cyclodextrin (MCD) incubations to remove membrane cholesterol or with incubations to increase membrane cholesterol content...
May 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29367407/an-interaction-between-serotonin-receptor-signaling-and-dopamine-enhances-goal-directed-vigor-and-persistence-in-mice
#14
Matthew R Bailey, Olivia Goldman, Estefanía P Bello, Muhammad O Chohan, Nuri Jeong, Vanessa Winiger, Eileen Chun, Elke Schipani, Abigail Kalmbach, Joseph F Cheer, Peter D Balsam, Eleanor H Simpson
The functionally selective 5-HT2C receptor ligand SB242084 can increase motivation and have rapid onset anti-depressant-like effects. We sought to identify the specific behavioral effects of SB242084 treatment and elucidate the mechanism in female and male mice. Using a quantitative behavioral approach, we determined that SB242084 increases the vigor and persistence of goal-directed activity across different types of physical work, particularly when work requirements are demanding. We found this influence of SB242084 on effort, rather than reward to be reflected in striatal DA measured during behavior...
February 28, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29349706/effect-of-the-combination-of-mephedrone-plus-ethanol-on-serotonin-and-dopamine-release-in-the-nucleus-accumbens-and-medial-prefrontal-cortex-of-awake-rats
#15
Raúl López-Arnau, Mario Buenrostro-Jáuregui, Jorge Camarasa, David Pubill, Elena Escubedo
Cathinones, such as mephedrone (Meph), are often co-abused with alcoholic drinks. In the present study, we investigated the combined effects of Meph plus ethanol (EtOH) on neurotransmitter release in the nucleus accumbens (NAc) and the medial prefrontal cortex (mPFC). A guide canula was stereotaxically implanted into either the NAc or the mPFC of male Sprague-Dawley rats. Seven days after surgery, a microdialysis probe was inserted and rats were administered saline, EtOH (1 g/kg, i.p.), Meph (25 mg/kg, s...
March 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29204954/chronic-fluoxetine-induces-activity-changes-in-recovery-from-poststroke-anxiety-depression-and-cognitive-impairment
#16
Faranak Vahid-Ansari, Paul R Albert
Poststroke depression (PSD) is a common outcome of stroke that limits recovery and is only partially responsive to chronic antidepressant treatment. In order to elucidate changes in the cortical-limbic circuitry associated with PSD and its treatment, we examined a novel mouse model of persistent PSD. Focal endothelin-1-induced ischemia of the left medial prefrontal cortex (mPFC) in male C57BL6 mice resulted in a chronic anxiety and depression phenotype. Here, we show severe cognitive impairment in spatial learning and memory in the stroke mice...
January 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29181815/effects-of-adolescent-alcohol-exposure-on-stress-induced-reward-deficits-brain-crf-monoamines-and-glutamate-in-adult-rats
#17
Nathalie Boutros, Andre Der-Avakian, James P Kesby, Soon Lee, Athina Markou, Svetlana Semenova
BACKGROUND: Adolescent alcohol exposure may increase depression vulnerability in adulthood by increasing the anhedonic response to stress. METHODS: Male Wistar rats (postnatal days 28-53) were exposed to binge-like adolescent intermittent ethanol (AIE) or water. In adulthood, rats were exposed to social defeat, consisting of daily confrontations with an aggressive conspecific, followed by testing of brain reward function in a discrete-trial current-intensity intracranial self-stimulation procedure for 10 consecutive days...
March 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29161023/the-in-vivo-neurochemical-profile-of-selectively-bred-high-responder-and-low-responder-rats-reveals-baseline-cocaine-evoked-and-novelty-evoked-differences-in-monoaminergic-systems
#18
Omar S Mabrouk, John L Han, Jenny-Marie T Wong, Huda Akil, Robert T Kennedy, Shelly B Flagel
Relative to bred low-responder (bLR) rats, bred high-responder (bHR) rats have an exaggerated locomotor response to a novel environment, take more risks, are more impulsive, and more likely to exhibit compulsive drug-seeking behaviors. These phenotypic differences in addiction-related behaviors and temperament have previously been associated with differences in neurotransmitter signaling, including the mesolimbic dopamine system. In this study, we applied advanced in vivo microdialysis sampling in the nucleus accumbens of bHRs and bLRs to assess differences in basal and stimulated neurochemical efflux more broadly...
April 18, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29123483/impact-of-vortioxetine-on-synaptic-integration-in-prefrontal-subcortical-circuits-comparisons-with-escitalopram
#19
Shreaya Chakroborty, Thomas R Geisbush, Elena Dale, Alan L Pehrson, Connie Sánchez, Anthony R West
Prefrontal-subcortical circuits support executive functions which often become dysfunctional in psychiatric disorders. Vortioxetine is a multimodal antidepressant that is currently used in the clinic to treat major depressive disorder. Mechanisms of action of vortioxetine include serotonin (5-HT) transporter blockade, 5-HT1A receptor agonism, 5-HT1B receptor partial agonism, and 5-HT1D , 5-HT3 , and 5-HT7 receptor antagonism. Vortioxetine facilitates 5-HT transmission in the medial prefrontal cortex (mPFC), however, the impact of this compound on related prefrontal-subcortical circuits is less clear...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29107702/intra-nasal-dopamine-alleviates-cognitive-deficits-in-tgdisc1-rats-which-overexpress-the-human-disc1-gene
#20
An-Li Wang, Benedetta Fazari, Owen Y Chao, Susanne Nikolaus, Svenja V Trossbach, Carsten Korth, Fernando J Sialana, Gert Lubec, Joseph P Huston, Claudia Mattern, Maria Angelica de Souza Silva
The Disrupted-in-Schizophrenia 1 (DISC1) gene has been associated with mental illnesses such as major depression and schizophrenia. The transgenic DISC1 (tgDISC1) rat, which overexpresses the human DISC1 gene, is known to exhibit deficient dopamine (DA) homeostasis. To ascertain whether the DISC1 gene also impacts cognitive functions, 14-15 months old male tgDISC1 rats and wild-type controls were subjected to the novel object preference (NOP) test and the object-based attention test (OBAT) in order to assess short-term memory (1 h), long-term memory (24 h), and attention...
December 2017: Neurobiology of Learning and Memory
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