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https://www.readbyqxmd.com/read/28524847/an-in-vivo-strategy-to-counteract-post-administration-anticoagulant-activity-of-azido-warfarin
#1
Sylvain Ursuegui, Marion Recher, Wojciech Krężel, Alain Wagner
Drugs, usually long acting and metabolically stable molecules, might be the source of adverse effects triggered by complex drug interactions, anaphylaxis and drug-induced coagulopathy. To circumvent this growing drug safety issue, we herein investigate the opportunity offered by bio-orthogonal chemistry for in vivo drug neutralization. We design a small-molecule anticoagulant drug (Warfarin) containing an azide group that acts as a safety pin. It allows drug deactivation and restoration of physiological coagulation via in vivo click reaction with a suitable cyclooctyne-based neutralizing agent...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28521089/nanoporous-block-polymer-thin-films-functionalized-with-bio-inspired-ligands-for-the-efficient-capture-of-heavy-metal-ions-from-water
#2
Jacob Logan Weidman, Ryan A Mulvenna, Bryan W Boudouris, William A Phillip
Heavy metal contamination of water supplies poses a serious threat to public health, prompting the development of novel and sustainable treatment technologies. One promising approach is to molecularly engineer the chemical affinity of a material for the targeted removal of specific molecules from solution. In this work, nanoporous polymer thin films generated from tailor-made block polymers were functionalized with the bio-inspired moieties glutathione and cysteamine for the removal of heavy metal ions, including lead and cadmium, from aqueous solutions...
May 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28512322/physicochemical-properties-of-dietary-phytochemicals-can-predict-their-passive-absorption-in-the-human-small-intestine
#3
Sophie N B Selby-Pham, Rosalind B Miller, Kate Howell, Frank Dunshea, Louise E Bennett
A diet high in phytochemical-rich plant foods is associated with reducing the risk of chronic diseases such as cardiovascular and neurodegenerative diseases, obesity, diabetes and cancer. Oxidative stress and inflammation (OSI) is the common component underlying these chronic diseases. Whilst the positive health effects of phytochemicals and their metabolites have been demonstrated to regulate OSI, the timing and absorption for best effect is not well understood. We developed a model to predict the time to achieve maximal plasma concentration (Tmax) of phytochemicals in fruits and vegetables...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28510424/structure-dependent-binding-of-hnrnp-a1-to-telomere-rna
#4
Xiao Liu, Takumi Ishizuka, Hong-Liang Bao, Kei Wada, Yuuma Takada, Keisuke Iida, Kazuo Nagasawa, Danzhou Yang, Yan Xu
Telomeric repeat-containing RNA is a new non-coding RNA molecule that performs various bio-functions. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein involved in the telomere maintenance machinery. To date, little is known about how hnRNPA1 binds to telomeric RNA. In this study, we investigated the binding affinity and recognition mechanism of telomere RNA with the RNA recognition motif (RRM) of hnRNPA1. Using the photochemical crosslinking method, we showed that the telomere RNA G-quadruplex with loops is important in the interaction of telomere RNA with hnRNPA1...
May 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28496980/silver-induced-reconstruction-of-an-adeninate-based-metal-organic-framework-for-encapsulation-of-luminescent-adenine-stabilized-silver-clusters
#5
Dries Jonckheere, Eduardo Coutino-Gonzalez, Wouter Baekelant, Bart Bueken, Helge Reinsch, Ivo Stassen, Oliver Fenwick, Fanny Richard, Paolo Samorì, Rob Ameloot, Johan Hofkens, Maarten B J Roeffaers, Dirk E De Vos
Bright luminescent silver-adenine species were successfully stabilized in the pores of the MOF-69A (zinc biphenyldicarboxylate) metal-organic framework, starting from the intrinsically blue luminescent bio-MOF-1 (zinc adeninate 4,4'-biphenyldicarboxylate). Bio-MOF-1 is transformed to the MOF-69A framework by selectively leaching structural adenine linkers from the original framework using silver nitrate solutions in aqueous ethanol. Simultaneously, bright blue-green luminescent silver-adenine clusters are formed inside the pores of the recrystallized MOF-69A matrix in high local concentrations...
May 21, 2016: Journal of Materials Chemistry. C, Materials for Optical and Electronic Devices
https://www.readbyqxmd.com/read/28496467/interference-free-determination-of-carbamazepine-in-human-serum-using-high-performance-liquid-chromatography-a-comprehensive-research-with-three-way-calibration-methods
#6
Shiva Ghafghazi, Taraneh Moini Zanjani, Maryam Vosough, Masoumeh Sabetkasaei
In the present study, a comprehensive and systematic strategy was described to evaluate the performance of several three-way calibration methods on a bio-analytical problem. Parallel factor analysis (PARAFAC), alternating trilinear decomposition (ATLD), self-weighted alternating trilinear decomposition (SWATLD), alternating penalty trilinear decomposition (APTLD), and unfolded partial least squares combined with the residual bilinearization procedure (U-PLS/RBL) were applied on high performance liquid chromatography with photodiode-array detection (HPLC-DAD) data to quantify carbamazepine (CBZ) in different serum samples...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28494219/oxidative-degradation-of-tetramethylammonium-hydroxide-tmah-by-uv-persulfate-and-associated-acute-toxicity-assessment
#7
Jingting Huang, Kai-Sung Wang, Chenju Liang
Tetramethylammonium hydroxide (TMAH) is widely used in high-tech industries as a developing agent. Ultraviolet (UV) light-activated persulfate (PS, S2O8(2-)) can be used to generate strongly oxidative sulfate radicals, and it also exhibits the potential to treat TMAH-containing wastewater. This study initially investigated the effect of S2O8(2-) concentration and UV strength on the UV/S2O8(2-) process for the degradation of TMAH in a batch reactor. The results suggested that 15 watts (W) of UV-activated S2O8(2-) at concentrations of 10 or 50 mM resulted in pseudo-first-order TMAH degradation rate constants of 3...
May 11, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28493026/structural-and-functional-characterization-of-a-novel-immunomodulatory-glycoprotein-isolated-from-ajowan-trachyspermum-ammi-l
#8
R R Shruthi, Y P Venkatesh, G Muralikrishna
Ajowan (Trachyspermum ammi L.) spice has been used in food preparations and also as a traditional medicine in Ayurveda. Although a number of pharmacological activities have been attributed to ajowan, its role in immunomodulation is not known. The main objective of the present study is to examine the macromolecular immunomodulatory components. Macrophage activation was studied by nitric oxide (NO) release, phagocytosis and secretion of pro-inflammatory cytokines as the markers. Ethanol precipitate (fractional) of ajowan aqueous extract was subjected to conventional chromatography (Q Sepharose followed by Bio-Gel P-100)...
May 10, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28491942/a-dataset-of-multi-contrast-population-averaged-brain-mri-atlases-of-a-parkinson-s-disease-cohort
#9
Yiming Xiao, Vladimir Fonov, M Mallar Chakravarty, Silvain Beriault, Fahd Al Subaie, Abbas Sadikot, G Bruce Pike, Gilles Bertrand, D Louis Collins
Parkinson׳s disease (PD) is a neurodegenerative disease that primarily affects the motor functions of the patients. Research and surgical treatment of PD (e.g., deep brain stimulation) often require human brain atlases for structural identification or as references for anatomical normalization. However, two pitfalls exist for many current atlases used for PD. First, most atlases do not represent the disease-specific anatomy as they are based on healthy young subjects. Second, subcortical structures, such as the subthalamic nucleus (STN) used in deep brain stimulation procedures, are often not well visualized...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28489946/transformation-of-nitrogen-and-evolution-of-n-containing-species-during-algae-pyrolysis
#10
Wei Chen, Haiping Yang, Yingquan Chen, Mingwei Xia, Xu Chen, Hanping Chen
Transformation and evolution mechanisms of nitrogen during algae pyrolysis were investigated with in depth exploration of N-containing products. Results indicated nitrogen in algae is mainly in the form of protein-N (~90%) with a little inorganic-N. At 400~600°C, protein-N in algae cracked firstly with algae pyrolysis and formed pyridinic-N, pyrrolic-N and quaternary-N in char. The content of protein-N and pyridinic-N decreased significantly, while that of pyrrolic-N and quaternary-N increased gradually with temperature increasing...
May 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28488318/platelet-rich-plasma-enhances-the-integration-of-bio-engineered-cartilage-with-native-tissue-in-an-in-vitro-model
#11
Corey Sermer, Rita Kandel, Jesse Anderson, Mark Hurtig, John Theodoropoulos
Current therapies for cartilage repair can be limited by an inability of the repair tissue to integrate with host tissue. Thus there is interest in developing approaches to enhance integration. We have previously shown that platelet-rich plasma (PRP) improves cartilage tissue formation. This raised the question as to whether PRP could promote cartilage integration. Chondrocytes were isolated from cartilage harvested from bovine joints, seeded on a porous bone substitute, and grown in vitro to form an osteochondral-like implant...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28484513/significantly-enhanced-biomass-production-of-a-novel-bio-therapeutic-strain-lactobacillus-plantarum-as-14-by-developing-low-cost-media-cultivation-strategy
#12
Asma Manzoor, Javed Iqbal Qazi, Ikram Ul Haq, Hamid Mukhtar, Akhtar Rasool
BACKGROUND: Probiotic bacteria are becoming an important tool for improving human health, controlling diseases and enhancing immune responses. The availability of a cost effective cultivation conditions has profound effect on the efficiency and role of probiotic bacteria. Therefore the current study was conducted with an objective to develop a low cost growth medium for enhancing the biomass production of a bio-therapeutic bacterial strain Lactobacillus plantarum AS-14. In this work the isolation of Lactobacillus plantarum AS-14 bacterial strain was carried out from brinjal using cheese whey as a main carbon source...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/28482481/mechanical-properties-and-bio-tribological-behaviors-of-novel-beta-zr-type-zr-al-fe-nb-alloys-for-biomedical-applications
#13
Nengbin Hua, Wenzhe Chen, Lei Zhang, Guanghui Li, Zhenlong Liao, Yan Lin
The present study prepares novel Zr70+xAl5Fe15-xNb10 (x=0, 5) alloys by arc-melting for potential biomedical application. The mechanical properties and bio-tribological behaviors of the Zr-based alloys are evaluated and compared with biomedical pure Zr. The as-prepared alloys exhibit a microstructure containing a micrometer-sized dendritic beta-Zr phase dispersed in a Zr2Fe-typed matrix. It is found that increasing the content of Zr is favorable for the mechanical compatibility with a combination of low Young's modulus, large plasticity, and high compressive strength...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482159/cascading-effects-of-nanoparticle-coatings-surface-functionalization-dictates-the-assemblage-of-complexed-proteins-and-subsequent-interaction-with-model-cell-membranes
#14
Eric S Melby, Samuel E Lohse, Ji Eun Park, Ariane M Vartanian, Rebecca A Putans, Hannah B Abbott, Robert J Hamers, Catherine J Murphy, Joel A Pedersen
Interactions of functionalized nanomaterials with biological membranes are expected to be governed by not only nanoparticle physiochemical properties, but also coatings or "coronas" of biomacromolecules acquired after emersion in biological fluids. Here, we prepared a library of 4-5 nm gold nanoparticles (AuNPs) coated with either ω-functionalized thiols or polyelectrolyte wrappings to examine the influence of surface functional groups on the assemblage of proteins complexing the nanoparticles and its subsequent impact on attachment to model biological membranes...
May 8, 2017: ACS Nano
https://www.readbyqxmd.com/read/28476988/plants-used-in-folkloric-medicine-of-iran-are-exquisite-bio-resources-in-production-of-silver-nanoparticles
#15
Mohadeseh Hassani Sadi, Gholam Hosein Shahidi Bonjar
This study reports screening of 102 Iranian medicinal plant species belonging to 49 families for the biosynthesis of colloidal silver nanoparticles (AgNPs). Among tested plants, 37 species in 19 plant families are new bio-resources in this regard. Water extracts of macerated plant parts are used in this survey. Six of the bioactive plants are selected for further analysis. They produced amorphous spherical 40-70 nm AgNPs. Biosynthesised colloidal AgNPs are characterised by UV-visible spectroscopy, transmission electron microscopy and scanning electron microscopy...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28476773/genome-stability-in-engineered-strains-of-the-extremely-thermophilic-lignocellulose-degrading-bacterium-caldicellulosiruptor-bescii
#16
Amanda M Williams-Rhaesa, Farris L Poole, Jessica T Dinsmore, Gina L Lipscomb, Gabriel M Rubinstein, Israel M Scott, Jonathan M Conway, Laura L Lee, Piyum A Khatibi, Robert M Kelly, Michael W W Adams
Caldicellulosiruptor bescii is the most thermophilic cellulose-degrader known and is of great interest because of its ability to degrade non-pretreated plant biomass. For biotechnological applications, an efficient genetic system is required to engineer it to convert plant biomass into desired products. To date, two different genetically-tractable lineages of C. bescii strains have been generated. The first (JWCB005) is based on a random deletion within the pyrimidine biosynthesis genes pyrFA, and the second (MACB1018) is based on the targeted deletion of pyrE making use of a kanamycin resistance marker...
May 5, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28474266/gas-phase-intercluster-thiyl-radical-induced-c-h-bond-homolysis-selectively-forms-sugar-c2-radical-cations-of-methyl-d-glucopyranoside-isotopic-labeling-studies-and-cleavage-reactions
#17
Sandra Osburn, Gaetano Speciale, Spencer J Williams, Richard A J O'Hair
A suite of isotopologues of methyl D-glucopyranosides is used in conjunction with multistage mass spectrometry experiments to determine the radical site and cleavage reactions of sugar radical cations formed via a recently developed 'bio-inspired' method. In the first stage of CID (MS(2)), collision-induced dissociation (CID) of a protonated noncovalent complex between the sugar and S-nitrosocysteamine, [H3NCH2CH2SNO + M](+), unleashes a thiyl radical via bond homolysis to give the noncovalent radical cation, [H3NCH2CH2S(•) + M](+)...
May 4, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28470257/bio-inspired-synthetic-approaches-from-hierarchical-hybrid-supramolecular-assemblies-to-caco3-based-microspheres
#18
Bartosz Marzec, Lei Zhang, Nianyong Zhu, Wolfgang Schmitt
A bio-inspired synthetic approach to unprecedented hybrid supramolecular assemblies [Ca(Me2hda)(H2O)3]·H2O (1) and [Ca(C12hda)(H2O)2]·H2O (2), that are stabilized by iminodiacetate-substituted organic ligands is reported. The results of the single-crystal X-ray analysis of 1 further allowed the use of electron microscopy to verify the supramolecular structure of the fibrous assemblies of 2 that incorporate extended alkyl-substituted ligand derivatives. 2 reveals interesting features that distinguish these soft structures from purely inorganic, brittle materials: meshes of nanobelts transform on solid supports to form homogeneous films covering extended, micro-sized areas...
May 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28464614/imaging-xps-and-photoemission-electron-microscopy-surface-chemical-mapping-and-blood-cell-visualization
#19
Andreas Skallberg, Caroline Brommesson, Kajsa Uvdal
Combined photoemission electron microscopy (PEEM) and imaging x-ray photoelectron spectroscopy (XPS), i.e., electron spectroscopy for chemical analysis in the nanoregion, has been used for surface characterization of bio-relevant and biological samples. In the first example, the authors prepared a gold patterned silicon substrate, stepwise surface modified by self-assembled monolayers followed by quantum dot (QDot) specific linking and investigated by means of work function mapping and elemental imaging in the submicrometer range...
May 2, 2017: Biointerphases
https://www.readbyqxmd.com/read/28459535/biobased-chitosan-nanocomposite-films-containing-gold-nanoparticles-obtainment-characterization-and-catalytic-activity-assessment
#20
Oscar Ramirez, Sebastián Bonardd, Cesar Saldías, Deodato Radic, Ángel Leiva
A "green" two-step methodology to prepare biobased gold-chitosan nanocomposite films using chitosan and AuCl4(-) as a stabilizer and precursor, respectively, is reported. The biobased nanocomposites were prepared in situ by a wet chemical reduction method. Effects of hydrazine and l-ascorbic acid as different strength reducing agents on the characteristics of gold nanoparticles were observed. In addition, the performance of these nanocomposite films as catalytic materials was assessed. The relevance of this work underlies that the catalytic activity, conversion degree and order of the reaction of the 4-nitrophenol-sodium borohydride (4NP-NaBH4) reduction system depend on the size distribution, content and mainly to the location of gold nanoparticles in the nanocomposite films...
May 3, 2017: ACS Applied Materials & Interfaces
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