keyword
https://read.qxmd.com/read/38273125/spinal-infection-after-vertebral-augmentation-a-covert-complication-with-serious-havoc
#21
JOURNAL ARTICLE
Hui Yuan, Yunchao Li, Jingyu Wang, Xiaobin Wang, Guohua Lü, Lei Kuang, Jing Li
INTRODUCTION: Vertebral augmentation, including percutaneous vertebroplasty (PVP) or kyphoplasty (PKP), is the current least invasive surgical option and has been widely used to treat the painful osteoporotic vertebral compression fractures (OVCF). However, the postoperative infections could be life-threatening, even though they rarely occur. Our studies aim to clarify the causation and outcomes of spinal infections following augmentation and meanwhile to identify the risk factors. METHODS: A retrospective study was conducted on patients with OVCF who underwent PVP or PKP, and were subsequently admitted to our institution with postoperative spinal infection between January 2010 and December 2022...
January 26, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38272791/evaluating-the-efficacy-of-combined-flap-coverage-antibiotic-loaded-bone-cement-and-negative-pressure-irrigation-in-traumatic-osteomyelitis-management
#22
JOURNAL ARTICLE
Bo Cong, Mingqi Chen
Traumatic osteomyelitis with accompanying soft tissue defects presents a significant therapeutic challenge. This prospective, randomised controlled trial aims to evaluate the efficacy of antibiotic-impregnated bone cement, flap coverage and negative pressure sealed irrigation in the management of traumatic osteomyelitis complicated by soft tissue defects. A total of 46 patients with clinically diagnosed traumatic osteomyelitis and soft tissue defects were randomised into a control group (n = 23) and an observation group (n = 23)...
January 2024: International Wound Journal
https://read.qxmd.com/read/38258202/a-nanoporous-3d-printed-scaffold-for-local-antibiotic-delivery
#23
JOURNAL ARTICLE
Pouyan Ahangar, Jialiang Li, Leslie S Nkindi, Zohreh Mohammadrezaee, Megan E Cooke, Paul A Martineau, Michael H Weber, Elie Saade, Nima Nateghi, Derek H Rosenzweig
Limitations of bone defect reconstruction include poor bone healing and osteointegration with acrylic cements, lack of strength with bone putty/paste, and poor osteointegration. Tissue engineering aims to bridge these gaps through the use of bioactive implants. However, there is often a risk of infection and biofilm formation associated with orthopedic implants, which may develop anti-microbial resistance. To promote bone repair while also locally delivering therapeutics, 3D-printed implants serve as a suitable alternative...
December 30, 2023: Micromachines
https://read.qxmd.com/read/38258104/pharmacokinetic-interpretation-of-applying-local-drug-delivery-system-for-the-treatment-of-deep-surgical-site-infection-in-the-spine
#24
JOURNAL ARTICLE
Ahmad Khalid Madadi, Moon-Jun Sohn
Surgical site infections (SSIs) after spinal surgery present significant challenges, including poor antibiotic penetration and biofilm formation on implants, leading to frequent treatment failures. Polymethylmethacrylate (PMMA) is widely used for localized drug delivery in bone infections, yet quantifying individual drug release kinetics is often impractical. This retrospective study analyzed 23 cases of deep SSIs (DSSIs) following spinal surgery treated with antibiotic-loaded PMMA. A mathematical model estimated personalized drug release kinetics from PMMA, considering disease types, pathogens, and various antibiotics...
January 10, 2024: Pharmaceutics
https://read.qxmd.com/read/38247603/impact-of-antibiotic-loaded-pmma-spacers-on-the-osteogenic-potential-of-hmscs
#25
JOURNAL ARTICLE
Jakob Hofmann, Tim Niklas Bewersdorf, Ulrike Sommer, Thomas Lingner, Sebastian Findeisen, Christian Schamberger, Gerhard Schmidmaier, Tobias Großner
Antibiotic-loaded PMMA bone cement is frequently used in modern trauma and orthopedic surgery. Although many of the antibiotics routinely applied are described to have cytotoxic effects in the literature, clinical experience shows no adverse effects for bone healing. To determine the effects of antibiotic-loaded PMMA spacers on osteogenesis in vitro, we cultivated human bone marrow mesenchymal stem cells (BM-hMSCs) in the presence of PMMA spacers containing Gentamicin, Vancomycin, Gentamicin + Clindamycin as well as Gentamicin + Vancomycin in addition to a blank control (agarose) and PMMA containing no antibiotics...
January 3, 2024: Antibiotics
https://read.qxmd.com/read/38218569/synergistic-effects-of-nano-curcumin-mediated-photodynamic-inactivation-and-nano-silver-colistin-against-pseudomonas-aeruginosa-biofilms
#26
JOURNAL ARTICLE
Masoud Azimzadeh, Grazia Greco, Abbas Farmani, Maryam Pourhajibagher, Amir Taherkhani, Mohammad Yousef Alikhani, Abbas Bahador
BACKGROUND: Patients with burn injuries colonized by multidrug-resistant P. aeruginosa face increased mortality risk. The efficacy of colistin, a last-resort treatment, is declining as resistance levels rise. P. aeruginosa's robust biofilm exacerbates antibiotic resistance. Photodynamic Inactivation (PDI) shows promise in fighting biofilm. MATERIALS AND METHODS: Nano curcumin (nCur) particles were synthesized, and their chemical characteristics were determined using zeta potential (ZP), dynamic light scattering analysis (DLS), and Fourier transform infrared (FTIR)...
January 11, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38214003/effects-of-vancomycin-and-tobramycin-on-compressive-and-tensile-strengths-of-antibiotic-bone-cement-a-biomechanical-study
#27
JOURNAL ARTICLE
Ernesto S Quinto, Nathan P Reyes, Brenden M Cutter, Noah D Paisner, Joshua P Steimel, JuEun Lee, Eric G Huish, William Holmes
PURPOSE: This study aims to compare the compressive and tensile strengths of bone cement mixed with various concentrations of vancomycin, tobramycin, and combinations of the two. METHODS: 12 mm × 6 mm antibiotic bone cement samples were created by vacuum mixing 0-4 g of vancomycin, tobramycin, and combinations of the two in 0.5 g increments per one pouch (40 g) of Palacos LV cement. An Instron 3369 Universal Testing System was used to determine the compressive and tensile strengths...
April 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38213566/masquelet-procedure-for-the-treatment-of-intra-articular-defects-of-the-wrist
#28
Priscilla A Jawahier, Laurien Waaijer, Philippe N d'Ailly, Niels W L Schep
Background  The purpose of this case series is to show our experiences with the Masquelet procedure in a variety of infected defects of the wrist. Case Description  All consecutive patients that were treated between 2015 and 2021 were included in this case series. Five patients were included with an infected defect of the wrist, involving the radiocarpal and/or the distal radioulnar joints (DRUJ). All patients underwent thorough debridement of the defect and the created void was filled with a gentamicin/vancomycin cement spacer...
December 2023: Journal of Wrist Surgery
https://read.qxmd.com/read/38206770/retention-of-antibiotic-cement-delivery-implants-in-orthopedic-infection-associated-with-united-fractures-does-not-increase-recurrence-risk
#29
JOURNAL ARTICLE
Abhishek Ganta, Lauren A Merrell, Jack Adams, Sanjit R Konda, Kenneth A Egol
OBJECTIVES: To evaluate if retention of antibiotic cement delivery devices after resolution of orthopedic infection is associated with recurrence. DESIGN: Retrospective Cohort. SETTING: Academic Medical Center. PATIENT SELECTION CRITERIA: Patients with a fracture definitively treated with internal fixation that went on to unite and developed a confirmed fracture-related infection or osteomyelitis following a remote fracture surgery, and had implantation of antibiotic-impregnated cement for infection management...
January 10, 2024: Journal of Orthopaedic Trauma
https://read.qxmd.com/read/38194787/preparation-and-characterizations-of-antibacterial-poly-methyl-methacrylate-bone-cement-via-copolymerization-with-a-quaternary-ammonium-monomer-of-dimethylaminotriclosan-methacrylate
#30
JOURNAL ARTICLE
Dong Liu, Haoyang Li, Yunping Yang, Shan Xu, Xihao Zheng, Jinkun Liu, Toshiki Miyazaki, Yan Zhu
Poly (methyl methacrylate) (PMMA) bone cement relies on the loaded antibiotic to realize the antibacterial purpose. But the exothermic behavior during setting often makes temperature-sensitive antibiotics inactivated. It is necessary to develop new material candidates to replace antibiotics. In this study, a new quaternary ammonium methacrylate (QAM) monomer called dimethylaminetriclosan methacrylate (DMATCM) was designed by the quaternization between 2-(Dimethylamino)ethyl methacrylate and triclosan, then employed as the modifier to explore the feasibility of equipping bone cement with antibacterial activity, and to investigate the variations on the physical and biological performances brought by the substitution ratio of DMATCM to MMA...
January 2, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38188639/organic-antibacterial-modifications-of-high-viscosity-glass-ionomer-cement-for-atraumatic-restorative-treatment-a-review
#31
REVIEW
Damodar Hegde, Baranya Shrikrishna Suprabha, Arathi Rao
High viscosity glass ionomer cement (HVGIC) has been employed as a restorative material for Atraumatic Restorative Treatment (ART). As residual caries persist after caries removal in ART, the antibacterial activity of HVGIC gains importance. Organic and inorganic substances with antibacterial properties have been incorporated into HVGIC over the years, and their effects on the antibacterial and physical properties have been studied. The objective of this paper is to review the various alterations made to HVGIC using organic compounds, their effect on the antibacterial activity, and the physical properties of the cement...
December 2024: Japanese Dental Science Review
https://read.qxmd.com/read/38167118/bone-reconstruction-with-modified-masquelet-technique-in-open-distal-femoral-fractures-a-case-series
#32
JOURNAL ARTICLE
Seyed Hadi Kalantar, Hana Saffar, Amir Human Hoveidaei
BACKGROUND: Large bone defects require complex treatment, multidisciplinary resources, and expert input, with surgical procedures ranging from reconstruction and salvage to amputation. The aim of this study was to provide the results of a case series of open comminuted intra-articular distal femoral fractures with significant bone loss that were managed by early fixation using anatomical plates and a modified Masquelet technique with the addition of surgical propylene mesh. METHODS: This retrospective study included all patients referred to our institution with OTA/AO C3 distal femur open fractures and meta-diaphyseal large bone loss between April 2019 and February 2021...
January 2, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38163551/3d-printed-antibiotic-loaded-bone-cement-spacers-as-adjunctive-therapy-for-hip-periprosthetic-infection-after-arthroplasty-a-clinical-assessment
#33
JOURNAL ARTICLE
Huikang Zhang, Suyang Zheng, Qingbai Liu, Peiran Wei, Fei Gu, Jiangping Yu, Zizheng Wang, Jiayi Li, Yan Xu, Cheng Tang, Qingqiang Yao, Chuanlin Du, Liming Wang
OBJECTIVE: To explore the effect of 3D-printing technology in assisting the treatment of periprosthetic infection after total hip arthroplasty (THA) by using personalized antibiotic-loaded bone cement (ALBC) spacers. METHODS: The data of 40 patients with postoperative infection after THA were retrospectively analyzed. The patients were divided into 3D printing group (age 47-78 years) and conventional group (age 57-78 years), with 20 cases in each group. In the stage I surgery, the 3D printing group used 3D printed silicone molds to create ALBC spacers, while the conventional group used traditional manual methods...
December 30, 2023: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38155732/antibiotic-cement-nails-manufactured-with-threaded-rods-or-cannulated-intramedullary-nails-are-better-than-those-made-with-guidewires-and-do-not-debond
#34
JOURNAL ARTICLE
Ryan Bray, Abdul K Zalikha, Emily Ren, Kerellos Nasr, Rahul Vaidya
PURPOSE: The purpose of this study was to comparatively evaluate cement debonding at the time of removal of antibiotic cemented coated nails (ABNs) with cores made with a guidewire ($120), a regular intramedullary nail ($1100) or a threaded rod from a circular frame external fixator set ($60). METHODS: A retrospective study was performed on 32 ABNs that had been implanted for long bone infections after intramedullary nailing. All ABNs were manufactured intraoperatively by the treating surgeon using 2 grams of vancomycin and single package of Tobramycin Simplex Cement (Stryker, Kalamazoo, MI)...
March 2024: OTA international: the open access journal of orthopaedic trauma
https://read.qxmd.com/read/38143147/evaluation-of-silver-nanoparticle-impregnated-pmma-loaded-with-vancomycin-or-gentamicin-against-bacterial-biofilm-formation
#35
JOURNAL ARTICLE
Jamil Faissal Soni, Victoria Stadler Tasca Ribeiro, Juliette Cieslinski, Ana Paula de Andrade, Letícia Ramos Dantas, Bruna Zanatta Pereira, Beatriz Martins Rodrigues Carvalho de Almeida, Paula Hansen Suss, Felipe Francisco Tuon
INTRODUCTION: Bone cement containing vancomycin or gentamicin is a therapeutic strategy for combating orthopedic infections: however, the activity of these antibiotics is narrow. Silver nanoparticles (AgNPs) are nanocomponents with a wide spectrum, including multidrug-resistant bacteria. In the present study, we aimed to evaluate the effect of AgNP-loaded polymethylmethacrylate (PMMA) on biofilm formation by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis...
November 2023: Injury
https://read.qxmd.com/read/38136756/improving-the-antibacterial-properties-of-dental-bonding-materials-loaded-with-silver-compounds
#36
JOURNAL ARTICLE
Elena Ferrando-Magraner, Verónica García-Sanz, Carlos Bellot-Arcís, Anna Marín-Gozalbo, Luís Cabedo-Mas, Gladys Mínguez-Vega, Vanessa Paredes-Gallardo
Biofilm accumulation, the appearance of white spot lesions and the development of secondary caries are the main complications in orthodontic patients. A promising approach to fight this situation is the development of adhesive cements with improved antibacterial properties. The aim of the present study was to evaluate the possibility of improving the antibacterial properties of glass ionomer cements by incorporating different types of antimicrobial compounds without altering their physical and mechanical properties...
December 13, 2023: Antibiotics
https://read.qxmd.com/read/38129302/-clinical-efficacy-of-antibiotic-bone-cement-combined-with-vacuum-sealing-drainage-in-treating-diabetes-mellitus-complicated-with-necrotizing-fasciitis
#37
JOURNAL ARTICLE
X F Guo, Z C Jin, X X Deng, Z H Huang, M Y Xue, F Y Bu
Objective: To explore the clinical efficacy of antibiotic bone cement combined with vacuum sealing drainage (VSD) in treating diabetes mellitus complicated with necrotizing fasciitis. Methods: The retrospective observational study approach was used. From January 2020 to March 2022, 12 patients with type 2 diabetes complicated with necrotizing fasciitis who met the inclusion criteria were admitted to Wuxi Ninth People's Hospital, including 7 males and 5 females, aged 27 to 76 years. The initial diagnosis of lesions was in the lower limbs...
December 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/38118069/antibiotic-loaded-bone-cement-combined-with-negative-pressure-wound-therapy-for-treating-sacrococcygeal-wound-following-sacral-chordoma-resection-a-case-report
#38
JOURNAL ARTICLE
Yanwei Sun
BACKGROUND: Sacral chordoma is a rare, malignant primary bone tumor with subtle clinical manifestations. The extensive cavity and soft tissue defect after radical resection of the tumor can lead to complications such as sacrococcygeal skin necrosis, infection, cerebrospinal fluid (CSF) leakage, and delayed healing or nonhealing. PURPOSE: To describe the treatment effect of the combination use of antibiotic-loaded bone cement (ALBC), a gluteus maximus muscle flap, and negative pressure wound therapy (NPWT) on the nonhealing sacrococcygeal wound after sacral chordoma resection...
November 2023: Wound Management & Prevention
https://read.qxmd.com/read/38116585/utilization-of-antibiotic-bone-cement-in-spine-surgery-pearls-techniques-and-case-review
#39
JOURNAL ARTICLE
Eren O Kuris, Camilo Osorio, George M Anderson, John Andrew Younghein, Christopher L McDonald, Alan H Daniels
Vertebral osteomyelitis (VO) encompasses a spectrum of spinal infections ranging from isolated mild vertebral osteomyelitis to severe diffuse infection with associated epidural abscess and fracture. Although patients can often be treated with an initial course of intravenous antibiotics, surgery is sometimes required in patients with sepsis, spinal instability, neurological compromise, or failed medical treatment. Antibiotic bone cement (ABC) has been widely used in orthopedic extremity surgery for more than 150 years, both for prophylaxis and treatment of bacterial infection...
2023: Orthopedic Reviews
https://read.qxmd.com/read/38108160/treatment-of-intractable-septic-ankle-arthritis-with-a-continuous-closed-irrigation-system
#40
JOURNAL ARTICLE
Tae-Hoon Kim, Ho-Seong Lee, Young-Rak Choi, Gyeong-Gu Bak, Sung-Hoo Kim, Sang-Gon Kim
OBJECTIVES: The study aimed to evaluate the efficacy of a continuous closed irrigation system (CCIS) after open debridement for patients with intractable septic ankle arthritis. PATIENTS AND METHODS: The retrospective study analyzed the intractable septic arthritis of 12 (6 males, 6 females; mean age: 64.1±14.7 years; range, 33 to 80 years) patients managed by CCIS between July 2015 and July 2020. All patients had previously undergone operations to treat septic ankle arthritis without resolution of the infection...
January 1, 2024: Joint diseases and related surgery
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