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https://www.readbyqxmd.com/read/29141147/a-water-soluble-galactose-decorated-cationic-photodynamic-therapy-agent-based-on-bodipy-to-selectively-eliminate-biofilm
#1
Xiaomei Dai, Xuelei Chen, Yu Zhao, Yunjian Yu, Xiaosong Wei, Xinge Zhang, Chaoxing Li
A multitude of serious chronic infections involved in bacterial biofilms that are difficult to eradicate. Here, a water-soluble galactose functionalized cationic 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based photodynamic therapy agent was synthesized for selectively eliminating the bacterial biofilm. These conjugates can capture bacteria to form aggregations through electrostatic interaction and then generate a large number of reactive oxygen species (ROS) under visible light irradiation to kill the bacteria without the emergence of bacterial resistance...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29139579/topical-adjuvants-incompletely-remove-adherent-staphylococcus-aureus-from-implant-materials
#2
Emily P Ernest, Anthony S Machi, Brock A Karolcik, P Rocco LaSala, Matthew J Dietz
Adjuvant treatments including Betadine, Dakin's solution (sodium hypochlorite), or hydrogen peroxide (H2O2) have been attempted to eradicate prosthetic joint infection caused by biofilm or intracellular bacteria. The purpose of this study was to evaluate the in vitro abilities of chemical adjuvants to decrease Staphylococcus aureus (S. aureus) biofilm presence on orthopaedic implant grade materials, including titanium, stainless steel, and cobalt chrome. S. aureus biofilms were grown for 48 hours and evaluated for baseline colony forming units/centimeter squared (CFU/cm(2) ) and compared to treatments with Betadine, Dakin's solution, H2 O2 , or 1% chlorine dioxide (ClO2 )...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29139571/human-prosthetic-joint-infections-are-associated-with-myeloid-derived-suppressor-cells-mdscs-implications-for-infection-persistence
#3
Cortney E Heim, Debbie Vidlak, Jessica Odvody, Curtis W Hartman, Kevin L Garvin, Tammy Kielian
Prosthetic joint infection (PJI) is a devastating complication of joint arthroplasty surgery typified by biofilm formation. Currently, mechanisms whereby biofilms persist and evade immune-mediated clearance in immune competent patients remain largely ill-defined. Therefore, the current study characterized leukocyte infiltrates and inflammatory mediator expression in tissues from patients with PJI compared to aseptic loosening. CD33(+) HLA-DR(-) CD66b(+) CD14(-/low) granulocytic myeloid-derived suppressor cells (G-MDSCs) were the predominant leukocyte population at sites of human PJI compared to aseptic tissues...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29138537/development-of-novel-ultrashort-antimicrobial-peptide-nanoparticles-with-potent-antimicrobial-and-antibiofilm-activities-against-multidrug-resistant-bacteria
#4
Ammar Almaaytah, Gubran Khalil Mohammed, Ahmad Abualhaijaa, Qosay Al-Balas
Conventional antibiotics are facing strong microbial resistance that has recently reached critical levels. This situation is leading to significantly reduced therapeutic potential of a huge proportion of antimicrobial agents currently used in clinical settings. Antimicrobial peptides (AMPs) could provide the medical community with an alternative strategy to traditional antibiotics for combating microbial resistance. However, the development of AMPs into clinically useful antibiotics is hampered by their relatively low stability, toxicity, and high manufacturing costs...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29138082/synthesis-of-chitosan-alginate-cs-alg-microspheres-with-high-antimicrobial-and-antibiofilm-activity-against-multi-drug-resistant-microbial-pathogens
#5
Rajagopalan Thaya, Baskaralingam Vaseeharan, Jeyachandran Sivakamavalli, Arokiadhas Iswarya, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Mohammed N Al-Anbr, Jamal M Khaled, Giovanni Benelli
The successful treatment of multi-drug resistant microbial pathogens represents a major challenge for public health management. Here, chitosan-alginate (CS/ALG) microspheres with narrow size distribution were fabricated by ionically cross linking method using Ca(2+) ions as agents for polymer solidification. The physicochemical properties of CS/ALG microspheres, such as surface morphology and size were studied by SEM and the functional group interactions were confirmed by Fourier transform infrared (FTIR) spectroscopy...
November 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29134109/erratum-author-correction-norgestimate-inhibits-staphylococcal-biofilm-formation-and-resensitizes-methicillin-resistant-staphylococcus-aureus-to-%C3%AE-lactam-antibiotics
#6
Yutaka Yoshii, Ken-Ichi Okuda, Satomi Yamada, Mari Nagakura, Shinya Sugimoto, Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Takeo Iwamoto, Kazuyoshi Kuwano, Yoshimitsu Mizunoe
[This corrects the article DOI: 10.1038/s41522-017-0026-1.].
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29133052/design-and-synthesis-of-short-amphiphilic-cationic-peptidomimetics-based-on-biphenyl-backbone-as-antibacterial-agents
#7
Rajesh Kuppusamy, Muhammad Yasir, Thomas Berry, Charles G Cranfield, Shashidhar Nizalapur, Eugene Yee, Onder Kimyon, Aditi Taunk, Kitty K K Ho, Bruce Cornell, Mike Manefield, Mark Willcox, David StC Black, Naresh Kumar
Antimicrobial peptides (AMPs) and their synthetic mimics have received recent interest as new alternatives to traditional antibiotics in attempts to overcome the rise of antibiotic resistance in many microbes. AMPs are part of the natural defenses of most living organisms and they also have a unique mechanism of action against bacteria. Herein, a new series of short amphiphilic cationic peptidomimetics were synthesized by incorporating the 3'-amino-[1,1'-biphenyl]-3-carboxylic acid backbone to mimic the essential properties of natural AMPs...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29126733/allicin-inspired-pyridyl-disulfides-as-antimicrobial-agents-for-multidrug-resistant-staphylococcus-aureus
#8
Jordan G Sheppard, Jeremy P McAleer, Pushkar Saralkar, Werner J Geldenhuys, Timothy E Long
A chemical library comprised of nineteen synthesized pyridyl disulfides that emulate the chemical reactivity of allicin (garlic) was evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (VISA, VRSA) demonstrated the highest level of susceptibility toward analogs with S-alkyl chains of 7-9 carbons in length. Further biological studies revealed that the disulfides display synergy with vancomycin against VRSA, cause dispersal of S...
October 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29125405/cutibacterium-formerly-propionibacterium-acnes-infections-associated-with-implantable-devices
#9
Amal A Gharamti, Zeina A Kanafani
Cutibacterium acnes (C. acnes), a Gram-positive biofilm-forming rod implicated in acne vulgaris, is increasingly recognized for its role in implant-associated infections. The diagnosis of C. acnes implant-associated infections remains challenging. The optimal treatment is a combination of both surgical intervention and antibiotic therapy. Areas Covered: In this review, we discuss the different types of implant-associated infections caused by C. acnes. We also highlight the clinical manifestations pertaining to the various sites of infection, and identify several risk factors previously reported in the literature...
November 10, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29124063/a-review-of-the-combination-therapy-of-low-frequency-ultrasound-with-antibiotics
#10
REVIEW
Yun Cai, Jin Wang, Xu Liu, Rui Wang, Lei Xia
Single antimicrobial therapy has been unable to resist the global spread of bacterial resistance. Literatures of available in vitro and in vivo studies were reviewed and the results showed that low frequency ultrasound (LFU) has a promising synergistic bactericidal effect with antibiotics against both planktonic and biofilm bacteria. It also can facilitate the release of antibiotics from medical implants. As a noninvasive and targeted therapy, LFU has great potential in treating bacterial infections. However, more in-depth and detailed studies are still needed before LFU is officially applied as a combination therapy in the field of anti-infective treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29121069/developing-selective-media-for-quantification-of-multispecies-biofilms-following-antibiotic-treatment
#11
Eva Vandeplassche, Tom Coenye, Aurélie Crabbé
The lungs of cystic fibrosis (CF) patients are chronically colonized by a polymicrobial biofilm community, leading to difficult-to-treat infections. To combat these infections, CF patients are commonly treated with a variety of antibiotics. Understanding the dynamics of polymicrobial community composition in response to antibiotic therapy is essential in the search for novel therapies. Culture-dependent quantification of individual bacteria from defined multispecies biofilms is frequently carried out by plating on selective media...
2017: PloS One
https://www.readbyqxmd.com/read/29119439/bacteriophage-treatment-of-infected-diabetic-foot-ulcers
#12
Vera V Morozova, Yulia N Kozlova, Denis A Ganichev, Nina V Tikunova
Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29113502/osteogenic-and-antibacterial-properties-of-vancomycin-laden-mesoporous-bioglass-plga-composite-scaffolds-for-bone-regeneration-in-infected-bone-defects
#13
Tao Cheng, Haiyun Qu, Guoyou Zhang, Xianlong Zhang
Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous bioactive glass (MBG) to form a local antibiotic delivery system and then a bone tissue-engineering scaffold combining MBG and poly-(L-lactic-co-glycolic acid) (PLGA) was prepared by freeze-drying fabrication. In vitro degradation and water contact angle analysis suggested that the MBG-incorporated PLGA scaffold exhibited controlled degradability, stabilizing the pH of the surrounding environment and improved the hydrophilicity...
November 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29113051/antibacterial-activity-of-the-non-cytotoxic-peptide-p-bthtx-i-%C3%A2-and-its-serum-degradation-product-against-multidrug-resistant-bacteria
#14
Norival A Santos-Filho, Rafaela S Fernandes, Bruna F Sgardioli, Matheus A S Ramos, Julia P Piccoli, Ilana L B C Camargo, Tais M Bauab, Eduardo M Cilli
Antimicrobial peptides can be used systemically, however, their susceptibility to proteases is a major obstacle in peptide-based therapeutic development. In the present study, the serum stability of p-BthTX-I (KKYRYHLKPFCKK) and (p-BthTX-I)₂, a p-BthTX-I disulfide-linked dimer, were analyzed by mass spectrometry and analytical high-performance liquid chromatography (HPLC). Antimicrobial activities were assessed by determining their minimum inhibitory concentrations (MIC) using cation-adjusted Mueller-Hinton broth...
November 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29111673/nano-into-micro-formulations-of-tobramycin-for-the-treatment-of-pseudomonas-aeruginosa-infections-in-cystic-fibrosis
#15
Barbara Porsio, Maria Grazia Cusimano, Domenico Schillaci, Emanuela Fabiola Craparo, Gaetano Giammona, Gennara Cavallaro
Here, nano into micro formulations (NiMs) of tobramycin for the treatment of Pseudomonas aeruginosa airway infections in cystic fibrosis (CF) are described. NiMs were produced by spray drying a solution containing polymers or sugars and a nanometric Polyanion-Tobramcyin Complex (PTC), able to achieve a prolonged antibiotic release. NiMs properties were compared to TOBI®Podhaler®(Novartis), the only one commercially available dry powder inhalatory formulation based on porous microparticles. Produced NiMs showed adequate characteristics for pulmonary administration, as spherical shape, micrometric size and high cytocompatibility towards human bronchial epithelial cells...
November 7, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29109808/sem-analysis-of-surface-impact-on-biofilm-antibiotic-treatment
#16
Luciana Calheiros Gomes, Filipe José Mergulhão
The aim of this work was to use scanning electron microscopy (SEM) to investigate the effect of ampicillin treatment on Escherichia coli biofilms formed on two surface materials with different properties, silicone (SIL) and glass (GLA). Epifluorescence microscopy (EM) was initially used to assess biofilm formation and killing efficiency on both surfaces. This technique showed that higher bacterial colonization was obtained in the hydrophobic SIL than in the hydrophilic GLA. It has also shown that higher biofilm inactivation was attained for GLA after the antibiotic treatment (7-log reduction versus 1-log reduction for SIL)...
2017: Scanning
https://www.readbyqxmd.com/read/29109186/insights-into-biofilm-dispersal-regulation-from-the-crystal-structure-of-the-pas-ggdef-eal-region-of-rbda-from-pseudomonas-aeruginosa
#17
Chong Liu, Chong Wai Liew, Yee Hwa Wong, Siok Thing Tan, Wee Han Poh, Sony M S Manimekalai, Sreekanth Rajan, Lingyi Xin, Zhao-Xun Liang, Gerhard Grüber, Scott A Rice, Julien Lescar
RbdA is a positive Regulator of biofilm dispersal of Pseudomonas aeruginosa Its cytoplasmic region (cRbdA) comprises a N-terminal PAS domain followed by a diguanylate cyclase (GGDEF) and an EAL domain, whose phosphodiesterase activity is allosterically stimulated by GTP binding to the GGDEF domain. We report crystal structures of cRbdA and of two binary complexes: with GTP/Mg(2+) bound to the GGDEF active site and with the EAL domain bound to the c-di-GMP substrate. These structures unveil a 2-fold symmetric dimer, stabilized by a closely packed N-terminal PAS domain and a non-canonical EAL dimer...
November 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/29104645/combined-effect-of-linolenic-acid-and-tobramycin-on-pseudomonas-aeruginosa-biofilm-formation-and-quorum-sensing
#18
Warren Chanda, Thomson Patrick Joseph, Arshad Ahmed Padhiar, Xuefang Guo, Liu Min, Wendong Wang, Sainyugu Lolokote, Anhong Ning, Jing Cao, Min Huang, Mintao Zhong
Pseudomonas aeruginosa is a ubiquitous Gram negative opportunistic pathogen capable of causing severe nosocomial infections in humans, and tobramycin is currently used to treat P. aeruginosa associated lung infections. Quorum sensing regulates biofilm formation which allows the bacterium to result in fatal infections forcing clinicians to extensively use antibiotics to manage its infections leading to emerging multiple drug resistant strains. As a result, tobramycin is also becoming resistant. Despite extensive studies on drug discovery to alleviate microbial drug resistance, the continued microbial evolution has forced researchers to focus on screening various phytochemicals and dietary compounds for antimicrobial potential...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29099716/definition-of-etiological-antibiotic-sensitivity-factors-in-purulent-inflammatory-processes
#19
O Dubovyk, М Mishyna, S Malanchuk, A Kuzmenko, O Kozlov
The purpose of the study - assessment of purulent-inflammatory processes etiologic factors and determination of microbial agents' in forms of plankton and biofilms sensitivity to antibiotics. Clinical microbial strains isolated from patients with purulent-inflammatory processes were the subject of the study. The study material comprised of wound tissue, pus, bandage and suture, catheters and drainage devices. Sensitivity of isolates to antimicrobial preparations with various mechanism of activity on the microbial cells was studied with the help of micro-test system...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29097211/infectious-crystalline-keratopathy
#20
REVIEW
Ashley J Porter, Graham A Lee, Albert S Jun
Infectious crystalline keratopathy (ICK) was first reported by Gorovoy et al in 1983 when they identified bacteria colonizing a cornea after a penetrating keratoplasty. Subsequent cases have elaborated on the organisms responsible and the management outcomes. Patients present with a white or grey branching opacity originating from an epithelial defect, commonly after a penetrating keratoplasty. Local immunosuppression contributes to the quiescent nature and the limited inflammatory response associated with ICK...
October 30, 2017: Survey of Ophthalmology
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