keyword
MENU ▼
Read by QxMD icon Read
search

chronic stress

keyword
https://www.readbyqxmd.com/read/29928969/long-term-exposure-to-environmental-concentrations-of-diesel-exhaust-particles-does-not-impact-the-phenotype-of-human-bronchial-epithelial-cells
#1
Camille C Savary, Nessrine Bellamri, Claudie Morzadec, Sophie Langouët, Valérie Lecureur, Laurent Vernhet
Chronic exposure to diesel engine exhausts is associated with an increased risk of pulmonary diseases including lung cancer. Diesel engine exhausts contain large amounts of diesel exhaust particles (DEP) on which are adsorbed several carcinogenic compounds such as polycyclic aromatic hydrocarbons. Acute toxicity of high concentrations of DEP has been largely demonstrated in various in vitro cellular models. In contrast, the cellular and molecular impacts of low environmental concentrations of DEP on the phenotype of chronically exposed lung epithelial cells remain to be investigated...
June 18, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29928950/contingency-training-alters-neurobiological-components-of-emotional-resilience-in-male-and-female-rats
#2
M Kent, S Scott, S Lambert, E Kirk, B Terhune-Cotter, B Thompson, S Neal, B Dozier, M Bardi, K Lambert
Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either six weeks of EBR training or noncontingent training prior to 10 days of exposure to chronic unpredictable stress (CUS). Subsequently, all animals were exposed to a problem-solving task and then trained in a spatial learning/foraging task, the dry land maze (DLM)...
June 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29928519/can-muscle-protein-metabolism-be-specifically-targeted-by-exercise-training-in-copd
#3
REVIEW
Davina C M Simoes, Ioannis Vogiatzis
Patients with stable chronic obstructive pulmonary disease (COPD) frequently exhibit unintentional accentuated peripheral muscle loss and dysfunction. Skeletal muscle mass in these patients is a strong independent predictor of morbidity and mortality. Factors including protein anabolism/catabolism imbalance, hypoxia, physical inactivity, inflammation, and oxidative stress are involved in the initiation and progression of muscle wasting in these patients. Exercise training remains the most powerful intervention for reversing, in part, muscle wasting in COPD...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928501/oxidative-and-endoplasmic-reticulum-stress-in-respiratory-disease
#4
REVIEW
Alice C-H Chen, Lucy Burr, Michael A McGuckin
Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29928140/involvement-of-the-nuclear-structural-proteins-in-aging-related-responses-of-human-skin-to-the-environmental-stress
#5
REVIEW
Ewa Markiewicz, Olusola Clement Idowu
Human skin is a stratified endocrine organ with primary roles in protection against detrimental biochemical and biophysical factors in the environment. Environmental stress causes gradual accumulation of the macromolecular damage and clinical manifestations consistent with chronic inflammatory conditions and premature aging of the skin. Structural proteins of cell nucleus, the nuclear lamins and lamina-associated proteins, play an important role in the regulation of a number of signal transduction pathways associated with stress...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29927755/integrated-breathlessness-services-for-people-with-chronic-conditions
#6
Claudia Bausewein, Philipp Schumacher, Anna Bolzani
PURPOSE OF REVIEW: Optimal management of breathlessness requires generally more than one component. Breathlessness services aim to provide specific interventions and support for patients suffering from breathlessness due to any advanced disease and their carers. This review aims to describe recent studies evaluating the effects of breathlessness services for patients with advanced chronic conditions. RECENT FINDINGS: Various breathlessness services have been tested and vary regarding structure, duration, frequency and professionals involved...
June 20, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29926759/childhood-victimization-recent-injustice-anger-and-forgiveness-in-a-sample-of-imprisoned-male-offenders
#7
Tomaž Erzar, Lifan Yu, Robert D Enright, Katarina Kompan Erzar
The links between childhood victimization, subsequent emotional dysregulation, and insufficient coping skills have been repeatedly documented in the scientific literature. However, there is a gap in the literature regarding the role of forgiveness as a coping strategy and relationships between offense-specific hurt, chronic anger, and early victimization. The goals of our study were (a) to explore how offenders cope with recent unjust treatment, and test the links between type of injustice, hurt experienced due to injustice, and use of forgiveness; (b) to test the links between childhood victimization, hurt, and chronic anger; and (c) to assess the mediating role of chronic anger in relation to hurt and forgiveness...
June 1, 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29926661/-improvement-of-hydrogen-on-liver-oxidative-stress-injury-in-chronic-intermittent-hypoxia-rats
#8
Sheng-Chang Yang, Ling-Ling Chen, Tian Fu, Wen-Ya Li, En-Sheng Ji
OBJECTIVE: To explore the effects of hydrogen on liver injury in chronic intermittent hypoxia rats and the related oxidative stress mechanism. METHODS: Twenty-four male adult SD rats were randomly divided into 3 groups( n =8):the normoxia group (Norm), the chronic intermittent hypoxia group (CIH), the chronic intermittent hypoxia and hydrogen group (H2 + CIH). Rats in Norm group were exposed in air, those in the other 2 groups suffered from chronic intermittent hypoxia conditions for 5 weeks...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926314/independent-and-relative-effects-of-stress-depressive-symptoms-and-affect-on-college-students-daily-health-behaviors
#9
Elizabeth D Dalton, Constance L Hammen
Stress and depressive symptoms are associated with maladaptive health behavior practices such as unhealthy eating, sedentary behavior, insufficient sleep, and substance use. The relative and interactive effects of stress and depressive symptoms on health behavior practices are less well understood. The present study examined these processes in a daily diary study of 127 college students. Results from hierarchical generalized linear models indicated that depressive symptoms, and chronic and daily stress, but not acute stressful life events, were significantly associated with a composite score of daily maladaptive health behavior engagement (depressive symptoms b = ...
June 20, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29926227/sarcopenia-in-a-mice-model-of-chronic-liver-disease-role-of-the-ubiquitin-proteasome-system-and-oxidative-stress
#10
Fabián Campos, Johanna Abrigo, Francisco Aguirre, Bruno Garcés, Marco Arrese, Saul Karpen, Daniel Cabrera, Marcelo E Andía, Felipe Simon, Claudio Cabello-Verrugio
Sarcopenia is the loss of muscle mass and strength produced by aging or secondary to chronic diseases such as chronic liver disease (CLD). Although not all types of sarcopenia involve the same features, the most common are decreased fiber diameter and myosin heavy chain (MHC) levels, increased activity of ubiquitin-proteasome system (UPS) and reactive oxygen species (ROS). In this study, we aim to characterize the development of sarcopenia secondary to CLD induced by the hepatotoxin 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)...
June 20, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29925687/androgen-excess-in-pancreatic-%C3%AE-cells-and-neurons-predisposes-female-mice-to-type-2-diabetes
#11
Guadalupe Navarro, Camille Allard, Jamie J Morford, Weiwei Xu, Suhuan Liu, Adrien Jr Molinas, Sierra M Butcher, Nicholas Hf Fine, Manuel Blandino-Rosano, Venkata N Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A Jacobson, Prasad V Katakam, David J Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis
Androgen excess predisposes women to type 2 diabetes (T2D), but the mechanism of this is poorly understood. We report that female mice fed a Western diet and exposed to chronic androgen excess using dihydrotestosterone (DHT) exhibit hyperinsulinemia and insulin resistance associated with secondary pancreatic β cell failure, leading to hyperglycemia. These abnormalities are not observed in mice lacking the androgen receptor (AR) in β cells and partially in neurons of the mediobasal hypothalamus (MBH) as well as in mice lacking AR selectively in neurons...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29925568/multi-omics-factor-analysis-a-framework-for-unsupervised-integration-of-multi-omics-data-sets
#12
Ricard Argelaguet, Britta Velten, Damien Arnol, Sascha Dietrich, Thorsten Zenz, John C Marioni, Florian Buettner, Wolfgang Huber, Oliver Stegle
Multi-omics studies promise the improved characterization of biological processes across molecular layers. However, methods for the unsupervised integration of the resulting heterogeneous data sets are lacking. We present Multi-Omics Factor Analysis (MOFA), a computational method for discovering the principal sources of variation in multi-omics data sets. MOFA infers a set of (hidden) factors that capture biological and technical sources of variability. It disentangles axes of heterogeneity that are shared across multiple modalities and those specific to individual data modalities...
June 20, 2018: Molecular Systems Biology
https://www.readbyqxmd.com/read/29925493/workshop-on-emerging-technology-and-data-analytics-for-behavioral-health
#13
David Kotz, Sarah E Lord, A James O'Malley, Luke Stark, Lisa A Marsch
Wearable and portable digital devices can support self-monitoring for patients with chronic medical conditions, individuals seeking to reduce stress, and people seeking to modify health-related behaviors such as substance use or overeating. The resulting data may be used directly by a consumer, or shared with a clinician for treatment, a caregiver for assistance, or a health coach for support. The data can also be used by researchers to develop and evaluate just-in-time interventions that leverage mobile technology to help individuals manage their symptoms and behavior in real time and as needed...
June 20, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29925460/the-symptomatology-of-psychological-trauma-in-the-aftermath-of-war-1945-1980-uk-army-veterans-civilians-and-emergency-responders
#14
Alberta Engelbrecht, Howard Burdett, Maria João Silva, Kamaldeep Bhui, Edgar Jones
BACKGROUND: UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS: A standardised form was used to collect data from pension records of a random sample of 500 UK army veterans from the first presentation in the 1940s until 1980...
June 21, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29923351/endophilina2-protects-against-angiotensin-ii-induced-cardiac-hypertrophy-by-inhibiting-angiotensin-ii-type-1-receptor-trafficking-in-neonatal-rat-cardiomyocytes
#15
Yun Liu, Huan-Jia Shen, Xin-Qiu-Yue Wang, Hai-Qi Liu, Ling-Yun Zheng, Jian-Dong Luo
Cardiac hypertrophy is one of the major risk factors for chronic heart failure. The role of endophilinA2 (EndoA2) in clathrin-mediated endocytosis and clathrin-independent endocytosis is well documented. In the present study, we tested the hypothesis that EndoA2 protects against angiotensin II (Ang II)-induced cardiac hypertrophy by mediating intracellular angiotensin II type 1 receptor (AT1-R) trafficking in neonatal rat cardiomyocytes (NRCMs). Cardiac hypertrophy was evaluated by using cell surface area and quantitative RT-PCR (qPCR) analyses...
June 20, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29923291/inflammation-of-brown-beige-adipose-tissues-in-obesity-and-metabolic-disease
#16
Francesc Villarroya, Rubén Cereijo, Aleix Gavaldà-Navarro, Joan Villarroya, Marta Giralt
Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases are related to the low-grade chronic inflammation of white adipose tissue. Under white adipocyte stress, local infiltration of immune cells and enhanced production of pro-inflammatory cytokines together reduce metabolic flexibility and lead to insulin resistance in obesity. Whereas white adipocytes act in energy storage, brown and beige adipocytes specialize in energy expenditure. Brown and beige activity protects against obesity and associated metabolic disorders, such as hyperglycemia and hyperlipidemia...
June 20, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29923288/social-genomics-of-healthy-and-disordered-internet-gaming
#17
Jeffrey G Snodgrass, H J François Dengah Ii, Michael G Lacy, Robert J Else, Evan R Polzer, Jesusa M G Arevalo, Steven W Cole
OBJECTIVES: To combine social genomics with cultural approaches to expand understandings of the somatic health dynamics of online gaming, including in the controversial nosological construct of internet gaming disorder (IGD). METHODS: In blood samples from 56 U.S. gamers, we examined expression of the conserved transcriptional response to adversity (CTRA), a leukocyte gene expression profile activated by chronic stress. We compared positively engaged and problem gamers, as identified by an ethnographically developed measure, the Positive and Negative Gaming Experiences Scale (PNGE-42), and also by a clinically derived IGD scale (IGDS-SF9)...
June 20, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29923067/hypertensive-disorders-of-pregnancy-and-cardiovascular-diseases-current-knowledge-and-future-directions
#18
REVIEW
Thais Coutinho, Olabimpe Lamai, Kara Nerenberg
PURPOSE OF THE REVIEW: Cardiovascular diseases (CVDs) are the principal killers of women. In this review, we summarize data regarding CVD and mortality after hypertensive disorders of pregnancy (HDP), and highlight clinical, research and policy needs to mitigate this risk. RECENT FINDINGS: Robust data indicate that women with HDP have substantially higher risk of future CVD, with a 3.7-fold increase in the risk of chronic hypertension, a 4.2-fold increase in the risk of heart failure, an 81% increase in the risk of stroke, and double the risk of atrial arrhythmias, coronary heart disease, and mortality when compared to women with normotensive pregnancies...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29922743/neuropathic-pain-drives-anxiety-behavior-in-mice-results-consistent-with-anxiety-levels-in-diabetic-neuropathy-patients
#19
Christine B Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L H Bennett, Juan D Ramirez, Andreas C Themistocleous, Andrew S C Rice, Pallai R Shillo, Solomon Tesfaye, Robert R Edwards, Nick A Andrews, Charles Berde, Michael Costigan
Background: Epidemiological studies in patients with neuropathic pain demonstrate a strong association with psychiatric conditions such as anxiety; however, the precipitating pathology between these symptoms remains unclear. To investigate this, we studied the effects of lifelong stress on levels of neuropathic pain-like behavior and conversely, the effects of chronic neuropathic injury on anxiety-like status in male and female mice. In addition, we assayed this link in painful and painless diabetic peripheral neuropathy patients...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922497/long-term-functional-results-of-a-wrist-exercise-program-for-patients-with-palmar-midcarpal-instability
#20
M A M Mulders, G S I Sulkers, A J Videler, S D Strackee, M J C Smeulders
Background  Patients with palmar midcarpal instability have symptoms of pain, combined with clinical signs of abnormal mobility on stressing the joint, an unpredictable blockade feeling, and a noticeable clunk, in the absence of an underlying trauma. No data are available on the effect of conservative treatment for these patients. Purpose  The purpose of this study was to evaluate the effect and the long-term functional outcomes of a wrist exercise program in patients with palmar midcarpal instability. Patients and Methods  All patients diagnosed with palmar midcarpal instability between 2005 and 2011 were included...
July 2018: Journal of Wrist Surgery
keyword
keyword
60159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"