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https://www.readbyqxmd.com/read/27914908/association-between-ventilatory-settings-and-development-of-acute-respiratory-distress-syndrome-in-mechanically-ventilated-patients-due-to-brain-injury
#1
Eva Tejerina, Paolo Pelosi, Alfonso Muriel, Oscar Peñuelas, Yuda Sutherasan, Fernando Frutos-Vivar, Nicolás Nin, Andrew R Davies, Fernando Rios, Damian A Violi, Konstantinos Raymondos, Javier Hurtado, Marco González, Bin Du, Pravin Amin, Salvatore M Maggiore, Arnaud W Thille, Marco Antonio Soares, Manuel Jibaja, Asisclo J Villagomez, Michael A Kuiper, Younsuck Koh, Rui P Moreno, Amine Ali Zeggwagh, Dimitrios Matamis, Antonio Anzueto, Niall D Ferguson, Andrés Esteban
PURPOSE: In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain injury. MATERIALS AND METHODS: We performed a secondary analysis of a prospective, observational study on mechanical ventilation...
November 18, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27900093/primary-gastrointestinal-stromal-tumour-of-the-ileum-pre-operatively-diagnosed-as-an-abdominal-abscess
#2
Patrizia Rubini, Francesco Tartamella
The present case report described the acute presentation, diagnosis and management of a primary gastrointestinal stromal tumour (GIST) of the ileum. A male patient (age, 51 years) was admitted to Maggiore Hospital (Parma, Italy) due to presenting with fever, dysuria and lower abdominal pain. Ultrasonography and computed tomography showed a 7,5×5,5-cm pelvic mass containing air and purulent fluid indicative of an intraperitoneal abscess. The patient was subjected to diagnostic laparoscopy, which revealed a huge, soft cystic mass arising from the small bowel...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27888705/chemotherapy-related-leukopenia-as-a-biomarker-predicting-survival-outcomes-in-locally-advanced-cervical-cancer
#3
Giorgio Bogani, Ilaria Sabatucci, Giuseppa Maltese, Francesca Lecce, Mauro Signorelli, Fabio Martinelli, Valentina Chiappa, Alice Indini, Umberto Leone Roberti Maggiore, Chiara Borghi, Giovanni Fucà, Antonino Ditto, Francesco Raspagliesi, Domenica Lorusso
OBJECTIVE: To investigate the impact of hematologic toxicity and leukopenia in locally advanced cervical cancer patients undergoing neoadjuvant chemotherapy (NACT). STUDY DESIGN: Data of consecutive patients undergoing platinum-based NACT followed by surgery were retrospectively searched in order to evaluate the impact of chemotherapy-related toxicity on survival outcomes. Toxicity was graded per the Common Terminology Criteria for Adverse Events (CTCAEv.4.03). Survival outcomes were evaluated using Kaplan-Meir and Cox hazard models...
November 19, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27882895/planar-maneuvering-control-of-underwater-snake-robots-using-virtual-holonomic-constraints
#4
Anna M Kohl, Eleni Kelasidi, Alireza Mohammadi, Manfredi Maggiore, Kristin Y Pettersen
This paper investigates the problem of planar maneuvering control for bio-inspired underwater snake robots that are exposed to unknown ocean currents. The control objective is to make a neutrally buoyant snake robot which is subject to hydrodynamic forces and ocean currents converge to a desired planar path and traverse the path with a desired velocity. The proposed feedback control strategy enforces virtual constraints which encode biologically inspired gaits on the snake robot configuration. The virtual constraints, parametrized by states of dynamic compensators, are used to regulate the orientation and forward speed of the snake robot...
November 24, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27873183/interdisciplinary-oncology-education-a-national-survey-of-trainees-and-program-directors-in-the-united-states
#5
Adil S Akthar, Christopher D Hellekson, Sabha Ganai, Olwen M Hahn, Ronald J Maggiore, Ezra E Cohen, Mitchell C Posner, Steven J Chmura, Andrew R Howard, Daniel W Golden
Oncologists must have a strong understanding of collaborating specialties in order to deliver optimal cancer care. The objective of this study was to quantify current interdisciplinary oncology education among oncology training programs across the USA, identify effective teaching modalities, and assess communication skills training. Web-based surveys were sent to oncology trainees and program directors (PDs) across the USA on April 1, 2013 and October 8, 2013, respectively. Question responses were Yes/No, five-point Likert scales (1 = not at all, 2 = somewhat, 3 = moderately, 4 = quite, 5 = extremely), or free response...
November 21, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27869905/-l-ortoressia-nervosa-in-un-campione-di-popolazione-universitaria-italiana
#6
Liliana Dell'Osso, Marianna Abelli, Barbara Carpita, Gabriele Massimetti, Stefano Pini, Luigi Rivetti, Federica Gorrasi, Rosalba Tognetti, Valdo Ricca, Claudia Carmassi
RIASSUNTO. Scopo. Valutare la frequenza e le caratteristiche dei comportamenti ortoressici in una vasta popolazione universitaria. Metodi. Un totale di 2826 individui hanno volontariamente completato in forma anonima l'ORTO-15 presente online, questionario autosomministrabile disegnato e validato con lo scopo di valutare la sintomatologia ortoressica. Come già fatto in studi precedenti, un punteggio totale all'ORTO-15 inferiore a 35 è stato utilizzato come soglia ottimale per evidenziare una tendenza per l'ortoressia nervosa...
September 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27797594/folate-receptor-alpha-antagonists-in-preclinical-and-early-stage-clinical-development-for-the-treatment-of-epithelial-ovarian-cancer
#7
Alice Bergamini, Simone Ferrero, Umberto Leone Roberti Maggiore, Carolina Scala, Francesca Pella, Valerio Gaetano Vellone, Micaela Petrone, Emanuela Rabaiotti, Raffaella Cioffi, Massimo Candiani, Giorgia Mangili
The prognosis of patients affected by ovarian cancer has not substantially changed in the last decades and improving survival still remains a challenge. In the promising era of "personalized therapy" several new biologic therapies are currently being investigated: in this setting, targeting the folate receptor (FR) has been considered a new potential strategy for biologic therapy. Areas covered. The aim of the current review is to summarize, giving a critical overview,promising folate receptor alpha antagonists under preclinical or early clinical development for ovarian cancer...
October 31, 2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27764931/-assessment-of-a-project-for-integrated-management-of-care-given-to-patients-with-type-2-diabetes-in-the-local-health-authority-21-of-legnago-veneto-region-northern-italy-in-the-period-2010-2012
#8
Alessandro Marcon, Alberto Vaona, Giulio Rigon, Marco Carazzolo, Franco Del Zotti, Sandro Girotto, Claudio Marafetti
OBIETTIVI: descrivere, nella ASL 21 di Legnago (VR), l'andamento di alcuni indicatori sanitari tra il 2009, anno precedente all'avvio di un progetto triennale per la gestione integrata dell'assistenza al paziente con diabete mellito di tipo 2, e il 2012, ultimo anno del progetto. DISEGNO: studio longitudinale trasversale ripetuto. SETTING E PARTECIPANTI: tutti i pazienti diabetici di tipo 2 della ASL 21, identificati nei database aziendali (in base a esenzioni per patologia, accessi al servizio diabetologico, consumo di farmaci antidiabetici e strisce per la determinazione della glicemia) e nelle cartelle cliniche dei medici di famiglia...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27764930/-national-epidemiological-surveillance-systems-of-mesothelioma-cases
#9
Pierpaolo Ferrante, Alessandra Binazzi, Claudia Branchi, Alessandro Marinaccio
: INTRODUZIONE: sebbene la relazione causale tra esposizione ad amianto e malattie neoplastiche sia ben nota, in molti Paesi il consumo del materiale è ancora rilevante e crescente. A causa della lunga latenza, nei Paesi dove è stato bandito (come in Italia) è oggi in corso un'epidemia di malattie correlate ad amianto. OBIETTIVI: descrivere i sistemi di sorveglianza dei mesoteliomi attivi nel mondo mediante un'analisi comparativa. METODI: è stata condotta una revisione bibliografica della letteratura disponibile sui sistemi di sorveglianza epidemiologica dei mesoteliomi attivi nel mondo, comparando metodi e risultati disponibili...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27764929/-mortality-from-respiratory-diseases-in-the-provinces-of-apulia-region-southern-italy-from-1933-to-2010
#10
Maria Rosa Montinari, Emilio Antonio Luca Gianicolo, Maria Angela Vigotti
OBIETTIVI: valutare l'andamento temporale della mortalità per patologie respiratorie nelle province pugliesi utilizzando dati omogenei per fonte e metodologia di calcolo. DISEGNO: analisi ecologica storica degli andamenti temporali di mortalità per tumori e patologie dell'apparato respiratorio nelle province pugliesi, in Puglia e nelle ripartizioni geografiche italiane dal 1933 al 2010. SETTING E PARTECIPANTI: i dati di mortalità e le popolazioni residenti sono di fonte Istat. Sono state esaminate tutte le cause di decesso, il tumore della laringe, il tumore del polmone, l'insieme dei tumori respiratori, la bronchite, la polmonite e la broncopolmonite considerate congiuntamente, e l'insieme delle patologie respiratorie...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27764927/-evaluation-of-mercury-exposure-in-populations-living-near-the-industrial-augusta-bay-sicily-region-southern-italy
#11
Maria Bonsignore, Nunzia Andolfi, Enza Maria Quinci, Anselmo Madeddu, Francesco Tisano, Vincenzo Ingallinella, Maria Castorina, Mario Sprovieri
: OBIETTIVI: valutare e quantificare l'esposizione umana al mercurio (Hg) ed esplorare i fattori chiave che influenzano la contaminazione nelle popolazioni residenti in prossimità della Rada di Augusta, un'area a elevato rischio ambientale a causa degli effetti degli sversamenti incontrollati di Hg da parte di uno dei più grandi impianti cloro-soda d'Europa. DISEGNO: un campione di residenti nei comuni di Augusta, Priolo e Melilli (Sicilia orientale) è stato selezionato per lo studio di biomonitoraggio umano...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27749199/geriatrics-fellowship-training-and-the-role-of-geriatricians-in-older-adult-cancer-care-a-survey-of-geriatrics-fellowship-directors
#12
Ronald J Maggiore, Kathryn E Callahan, Janet A Tooze, Ira R Parker, Tina Hsu, Heidi D Klepin
The number of older adults with cancer is growing, necessitating more collaborative training in both geriatric principles and cancer care. We administered a web-based survey to U.S. geriatrics program directors (PDs) addressing cancer-specific training and perspectives on optimal training content and roles for geriatricians in cancer care. Of 140 PDs contacted, 67 (48%) responded. Topics considered very important in training included cancer screening (79%) and cancer-related pain management (70%). Respondents strongly agreed that some of the geriatrician's roles in cancer care included assessing functional status (64%) and assessing physical/cognitive function for goals of care (64%)...
October 17, 2016: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/27743614/reliability-of-bedside-ultrasound-for-measurement-of-quadriceps-muscle-thickness-in-critically-ill-patients-with-acute-kidney-injury
#13
Alice Sabatino, Giuseppe Regolisti, Laura Bozzoli, Filippo Fani, Riccardo Antoniotti, Umberto Maggiore, Enrico Fiaccadori
MAIN PROBLEM: In patients with Acute Kidney Injury there is a lack of nutritional variables that can assess nutritional status, more specifically lean body mass (LBM) and skeletal muscle mass, at the individual level. In this clinical setting, ultrasound (US)) of the quadriceps femoris could represent a widely available, non-invasive, affordable, and reliable tool to evaluate skeletal muscle. METHODS: We performed a cross-sectional observational study in adult critically ill patients with KDIGO stage 3 AKI on dialysis...
October 1, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27742386/the-bad-and-the-good-news-on-cancer-immunotherapy-implications-for-organ-transplant-recipients
#14
Umberto Maggiore, Julio Pascual
Cancer immunotherapy, especially the use of checkpoint inhibitors, is expanding and can be efficacious in organ transplant recipients with malignant neoplasia. In this review, we summarize clinical findings and evolution of several patients treated with CTL4-4 or PD-1 inhibitors reported in the literature. The CTL-4 inhibitor ipilimumab has been safely used in several liver and kidney allograft recipients. PD1-inhibitors look promising for tumor shrinking, but acute rejection is the rule, so they should be avoided in recipients of life-saving organs...
September 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/27727265/-valutazione-del-carico-gestionale-in-un-centro-diurno-psichiatrico-gravosit%C3%A3-e-recovery-style
#15
Camilla Callegari, Ivano Caselli, Lorenza Bertù, Emanuela Berto, Simone Vender
RIASSUNTO. Scopo. Nella riabilitazione psichiatrica il piano di trattamento individuale può essere formulato a partire da strumenti che offrano una valutazione multidimensionale del paziente. Il lavoro si propone di analizzare il rapporto tra gravosità (distress degli operatori) e stile di recupero (integration e sealing over) dalla patologia psicotica. Ipotizzando che esso influenzi il carico gestionale, lo studio si pone l'ulteriore obiettivo di acquisire maggiori elementi che indirizzino la formulazione di piani terapeutico-riabilitativi più efficaci...
July 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27727264/-lo-stile-di-attaccamento-insicuro-%C3%A3-un-fattore-di-rischio-di-ridotta-densit%C3%A3-minerale-ossea-in-donne-in-menopausa-uno-studio-pilota
#16
Cinzia Niolu, Emanuela Bianciardi, Giorgio Di Lorenzo, Sara Nicolai, Monica Celi, Michele Ribolsi, Adalgisa Pietropolli, Carlo Ticconi, Umberto Tarantino, Alberto Siracusano
RIASSUNTO. Introduzione. La depressione maggiore (MD) e l'osteoporosi sono malattie ad alta prevalenza nel genere femminile, associate a morbosità e mortalità. Sebbene alcuni studi abbiano dimostrato un'associazione tra MD, ridotta densità minerale ossea (BMD) e osteoporosi, non sono stati chiariti i meccanismi causali. Lo stile di attaccamento insicuro è stato messo in relazione con la patogenesi e il decorso di malattie croniche come la MD e le malattie cardiovascolari. Obiettivo di questo studio pilota è esplorare la relazione tra MD e BMD...
July 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27702704/minimally-invasive-surgical-staging-for-ovarian-carcinoma-a-propensity-matched-comparison-with-traditional-open-surgery
#17
Antonino Ditto, Giorgio Bogani, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Cono Scaffa, Alice Indini, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
STUDY OBJECTIVE: Growing evidence supports the safety of laparoscopic approach for patients affected by apparent early stage ovarian cancer (eEOC). However, no well-designed studies comparing laparoscopic (LS) and open surgical staging (OSS) are available. In the present investigation we aimed to provide a balanced long-term comparison between these two approaches. DESIGN: Retrospective study DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING: Tertiary Centre PATIENTS: Data of consecutive patients affected by eEOC who had LS were matched 1:1 with a cohort of patients undergoing OSS...
October 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679194/computed-tomographic-colonography-in-the-diagnosis-of-recto-sigmoid-endometriosis-a-pilot-study
#18
A Racca, E Biscaldi, V Remorgida, U Leone Roberti Maggiore, V G Vellone, P L Venturini, S Ferrero
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679134/unidirectional-knotless-barbed-suture-for-laparoscopic-myomectomy-fertility-pregnancy-and-delivery-outcomes
#19
A Racca, F Alessandri, U Leone Roberti Maggiore, S Fausta, P L Venturini, S Ferrero
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678974/ulipristal-acetate-prior-to-high-complexity-hysteroscopic-myomectomy-prospective-study
#20
S Ferrero, E Tafi, A Racca, Roberti Leone, U Maggiore, V Remorgida, P L Venturini
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
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