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https://www.readbyqxmd.com/read/29304013/breastfeeding-determinants-in-healthy-term-newborns
#1
Lorenzo Colombo, Beatrice Letizia Crippa, Dario Consonni, Maria Enrica Bettinelli, Viola Agosti, Giulia Mangino, Elena Nicoletta Bezze, Paola Agnese Mauri, Lidia Zanotta, Paola Roggero, Laura Plevani, Donatella Bertoli, Maria Lorella Giannì, Fabio Mosca
Breastfeeding is the normative standard for infant feeding. Despite its established benefits, different factors can affect breastfeeding rates over time. The purpose of this study was to evaluate breastfeeding determinants in healthy term newborns during the first three months of life. A prospective, observational, single-center study was conducted in the nursery of Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in Milan, Italy. The mother-baby dyads that were admitted to the Clinic in January and February 2017 were enrolled...
January 5, 2018: Nutrients
https://www.readbyqxmd.com/read/29286013/outbreak-of-severe-hepatitis-a-in-eastern-piedmont-italy
#2
Antonella Rossati, Olivia Bargiacchi, Vesselina Kroumova, Claudio Nebbiolo, Maria Grazia Tacca, Sonia Pratillo, Pietro Luigi Garavelli
Hepatitis A (HA) is caused by a hepatovirus from the family Picornaviridae (Hepatitis A Virus, HAV). Transmission occurs mainly by the orofaecal route through food or water contaminated by faeces. Sexual transmission has also been reported among men who have sex with men (MSM). From February to May 2017, 14 patients with HA were hospitalized at the University Hospital "Maggiore della Carità", Novara (Eastern Piedmont), Italy. One patient was two years old and was therefore admitted to the Paediatric Unit, the remaining 13 to the Infectious Disease Unit...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29244742/fibrinogen-gamma-chain-mutations-provoke-fibrinogen-and-apolipoprotein-b-plasma-deficiency-and-liver-storage
#3
Francesco Callea, Isabella Giovannoni, Sinan Sari, Esendagli Guldal, Buket Dalgic, Gulen Akyol, Tsuyoshi Sogo, Abdulrahman Al-Hussaini, Giuseppe Maggiore, Andrea Bartuli, Renata Boldrini, Paola Francalanci, Emanuele Bellacchio
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage of the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from the Caribbean, Europe, Japan, Saudi Arabia, Turkey, and China. All reported children presented with a variable degree of histologically proven chronic liver disease and low plasma fibrinogen levels. In addition, one Japanese and one Turkish child had concomitant hypo-APOB-lipoproteinemia of unknown origin...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29233784/altered-natural-killer-cell-cytokine-profile-in-type-2-autoimmune-hepatitis
#4
Dalila Mele, Grazia Bossi, Giuseppe Maggiore, Barbara Oliviero, Stefania Mantovani, Beatrice Bonelli, Mario U Mondelli, Stefania Varchetta
Type 2 autoimmune hepatitis (AIH-2) is a rare disease presenting in early childhood. The immunopathogenetic mechanisms are poorly characterized, although a defect of regulatory T cells (Treg) has been shown. There is virtually no information on innate immune responses and natural killer (NK) cells in particular. We have performed an extended immunophenotypic and functional analysis of NK cells in children with AIH-2. We show that NK cell frequency is reduced in this setting and that the balance between NK activating and inhibitory receptors is skewed toward activation...
December 9, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29228373/medical-treatment-or-surgery-for-colorectal-endometriosis-results-of-a-shared-decision-making-approach
#5
Paolo Vercellini, Maria Pina Frattaruolo, Riccardo Rosati, Dhouha Dridi, Anna Roberto, Paola Mosconi, Olga De Giorgi, Fulvia Milena Cribiù, Edgardo Somigliana
STUDY QUESTION: What is the degree of patient satisfaction in women with symptomatic colorectal endometriosis who choose medical or surgical treatment after a shared decision-making (SDM) process? SUMMARY ANSWER: The degree of satisfaction with treatment was high both in women who chose medical treatment with a low-dose oral contraceptive (OCP) or a progestin, and in those who chose to undergo surgical resection of bowel endometriosis. WHAT IS KNOWN ALREADY: Hormonal therapies and surgery for colorectal endometriosis have been investigated in non-comparative studies with inconsistent results...
December 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29206777/to-the-editor
#6
Umberto Leone Roberti Maggiore, Simone Ferrero
No abstract text is available yet for this article.
December 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29204431/efficacy-of-ventilator-waveform-observation-for-detection-of-patient-ventilator-asynchrony-during-niv-a-multicentre-study
#7
Federico Longhini, Davide Colombo, Lara Pisani, Francesco Idone, Pan Chun, Jonne Doorduin, Liu Ling, Moreno Alemani, Andrea Bruni, Jin Zhaochen, Yu Tao, Weihua Lu, Eugenio Garofalo, Luca Carenzo, Salvatore Maurizio Maggiore, Haibo Qiu, Leo Heunks, Massimo Antonelli, Stefano Nava, Paolo Navalesi
The objective of this study was to assess ability to identify asynchronies during noninvasive ventilation (NIV) through ventilator waveforms according to experience and interface, and to ascertain the influence of breathing pattern and respiratory drive on sensitivity and prevalence of asynchronies. 35 expert and 35 nonexpert physicians evaluated 40 5-min NIV reports displaying flow-time and airway pressure-time tracings; identified asynchronies were compared with those ascertained by three examiners who evaluated the same reports displaying, additionally, tracings of diaphragm electrical activity...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29202964/obstetrical-complications-of-endometriosis-particularly-deep-endometriosis
#8
REVIEW
Umberto Leone Roberti Maggiore, Annalisa Inversetti, Matteo Schimberni, Paola Viganò, Veronica Giorgione, Massimo Candiani
Over the past few years, a new topic in the field of endometriosis has emerged: the potential impact of the disease on pregnancy outcomes. This review aims to summarize in detail the available evidence on the relationship between endometriosis, particularly deep endometriosis (DE), and obstetrical outcomes. Acute complications of DE, such as spontaneous hemoperitoneum, bowel perforation, and uterine rupture, may occur during pregnancy. Although these events represent life-threatening conditions, they are rare and unpredictable...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29191471/nerve-sparing-approach-improves-outcomes-of-patients-undergoing-minimally-invasive-radical-hysterectomy-a-systematic-review-and-meta-analysis
#9
REVIEW
Giorgio Bogani, Diego Oreste Rossetti, Antonino Ditto, Mauro Signorelli, Fabio Martinelli, Lavinia Mosca, Cono Scaffa, Umberto Leone Roberti Maggiore, Valentina Chiappa, Ilaria Sabatucci, Domenica Lorusso, Francesco Raspagliesi
Few studies investigated the efficacy and safety of nerve sparing approach via minimally invasive surgery for the treatment of cervical cancer. We aimed to review the current evidence comparing nerve sparing minimally invasive radical hysterectomy (NS-MRH) and conventional minimally invasive radical hysterectomy (MRH). This systematic review was registered in the International Prospective Register of Systematic Reviews (CRD#57655). Overall, 675 patients were included: 350 (51.9%) and 325 (48.1%) patients undergoing MRH and NS-MRH, respectively...
November 27, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29145062/differentiating-multiple-vs-single-lifetime-suicide-attempters-with-bipolar-disorders-a-retrospective-study
#10
Chiara Arici, Laura Cremaschi, Cristina Dobrea, Matteo Vismara, Benedetta Grancini, Beatrice Benatti, Massimiliano Buoli, Shefali Miller, Terence A Ketter, A Carlo Altamura, Bernardo Dell'Osso
BACKGROUND: The risk of suicide in Bipolar Disorder (BD) has been estimated up to 20-30 times higher compared with the general population. Previous suicide attempts (SAs) represent a well-established risk factor for further attempts and for death by suicide in patients with psychiatric disorders. However, little is known about the socio-demographic and clinical profile of BD patients with a history of multiple SAs (MSAs). The present study sought to characterize BD patients with MSAs versus single suicide attempt (SSA) within a large Italian sample...
October 19, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29143292/tribute-to-professor-quirino-maggiore-december-17-1933-september-2-2017-founder-and-first-editor-in-chief-of-the-journal-of-nephrology
#11
EDITORIAL
Francesco Pizzarelli, Salvatore Di Giulio
No abstract text is available yet for this article.
November 15, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29105699/-fisiopatologia-dei-comportamenti-aggressivi-in-salute-mentale
#12
Enrico Pompili, Cristiano Carlone, Cristiana Silvestrini, Giuseppe Nicolò
RIASSUNTO. Introduzione. L'aggressività è un comportamento con origini evolutive, ma nella società di oggi è spesso distruttivo e disadattivo. Un aumento del comportamento aggressivo è presente in molte malattie mentali e rappresenta una sfida clinica per il servizio sanitario. Questi fenomeni possono portare ad agiti dannosi e violenti, rappresentando una grave preoccupazione per la salute pubblica. L'aggressività è spesso motivo di ospedalizzazione psichiatrica, e può portare a soggiorni ospedalieri prolungati, sofferenze dei pazienti e delle loro vittime con aumento della stigmatizzazione...
September 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29081931/atypical-clinical-presentation-and-successful-treatment-with-oral-cholic-acid-of-a-child-with-defective-bile-acid-synthesis-due-to-a-novel-mutation-in-the-hsd3b7-gene
#13
Grazia Bossi, Giuseppe Giordano, Gaetana Anna Rispoli, Giuseppe Maggiore, Mauro Naturale, Daniela Marchetti, Maria Iascone
We report definitive diagnosis and effective treatment with oral cholic acid in one Italian male child affected by 3β-hydroxy-Δ(5)-C(27)-steroid dehydrogenase (3β-HSD) deficiency. He presented with failure to thrive, hepatomegaly and multiple cystic images in kidneys; no biochemical evidence of cholestasis. Large amounts of bile acid metabolites was detected in urine by fast atom bombardment ionization mass spectrometry (FAB-MS). HSDH3B7 gene analysis identified one mutation in intron 4, at nucleotide 432, G>A substitution that has never been reported before...
October 6, 2017: Pediatric Reports
https://www.readbyqxmd.com/read/29064913/the-impact-of-number-of-cycles-of-neoadjuvant-chemotherapy-on-survival-of-patients-undergoing-interval-debulking-surgery-for-stage-iiic-iv-unresectable-ovarian-cancer-results-from-a-multi-institutional-study
#14
Giorgio Bogani, Laura Matteucci, Stefano Tamberi, Valentina Arcangeli, Antonino Ditto, Giuseppa Maltese, Mauro Signorelli, Fabio Martinelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Stefania Perotto, Cono Scaffa, Giuseppe Comerci, Marco Stefanetti, Francesco Raspagliesi, Domenica Lorusso
OBJECTIVES: Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) may be a valuable treatment option in advanced ovarian cancer when primary cytoreduction is not feasible. However, a consensus on the ideal number of NACT cycles is still lacking. In the present investigation, we aimed to evaluate how number of cycles of NACT influenced patients' outcomes. METHODS: Data of consecutive patients undergoing NACT and IDS were retrospectively reviewed in 4 Italian centers, and survival outcomes were evaluated...
November 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29034161/going-green-ex-post-valuation-of-a-multipurpose-water-infrastructure-in-northern-italy
#15
Arnaud Reynaud, Denis Lanzanova, Camino Liquete, Bruna Grizzetti
A contingent valuation approach is used to estimate how households value different multipurpose infrastructures (conventional or green) for managing flood risk and water pollution. As a case study we consider the Gorla Maggiore water park located in the Lombardy Region, in Northern Italy. The park is a neo-ecosystem including an infrastructure to treat waste water and store excess rain water, built in 2011 on the shore of the Olona River in an area previously used for poplar plantation. This park is the first one of this type built in Italy...
October 2017: Ecosystem Services
https://www.readbyqxmd.com/read/29019854/the-best-choice-for-second-line-treatment-in-standard-treatment-refractory-children-with-autoimmune-hepatitis
#16
Silvia Nastasio, Marco Sciveres, Giuseppe Maggiore
No abstract text is available yet for this article.
October 10, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28978238/ototoxicity-monitoring-through-the-eyes-of-the-treating-physician-perspectives-from-pulmonology-and-medical-oncology
#17
Angela C Garinis, Alexandra Cornell, Gopal Allada, Kevin P Fennelly, Ronald J Maggiore, Dawn Konrad-Martin
OBJECTIVES: Integrating audiological management into the care pathways of clinical specialties that prescribe ototoxic medications for essential, often life-preserving medical care that is critical for early hearing loss identification and remediation. Research shows that successful implementation of a new health service or intervention requires alignment of goals among provider groups, institutional leadership and patients. Thoughtful consideration of the physician's viewpoints about ototoxicity and its implications for treatment planning is, therefore, important for the implementation and enduring success of an ototoxicity monitoring programme (OMP)...
October 5, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28976448/invasive-paget-disease-of-the-vulva
#18
Chiara Borghi, Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Cono Scaffa, Stefania Perotto, Umberto Leone Roberti Maggiore, Dario Recalcati, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Extramammary Paget disease of the vulva (EPDV) is a rare occurrence with an indolent and relapsing course. Progression to invasion occurs in 4% to 19% of cases. The aim of this study is to report clinical-pathological features and outcomes of patients treated for invasive EPDV. METHODS: Data of consecutive patients treated between 2000 and 2017 for invasive EPDV were reviewed. RESULTS: Among 79 patients with EPDV, 10 (12.7%) presented a microinvasive or invasive form at first diagnosis or during follow-up...
October 3, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28933744/energy-and-protein-in-critically-ill-patients-with-aki-a-prospective-multicenter-observational-study-using-indirect-calorimetry-and-protein-catabolic-rate
#19
Alice Sabatino, Miriam Theilla, Moran Hellerman, Pierre Singer, Umberto Maggiore, Maria Barbagallo, Giuseppe Regolisti, Enrico Fiaccadori
The optimal nutritional support in Acute Kidney Injury (AKI) still remains an open issue. The present study was aimed at evaluating the validity of conventional predictive formulas for the calculation of both energy expenditure and protein needs in critically ill patients with AKI. A prospective, multicenter, observational study was conducted on adult patients hospitalized with AKI in three different intensive care units (ICU). Nutrient needs were estimated by different methods: the Guidelines of the European Society of Parenteral and Enteral Nutrition (ESPEN) for both calories and proteins, the Harris-Benedict equation, the Penn-State and Faisy-Fagon equations for energy...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28927778/introducing-nerve-sparing-approach-during-minimally-invasive-radical-hysterectomy-for-locally-advanced-cervical-cancer-a-multi-institutional-experience
#20
Francesco Raspagliesi, Giorgio Bogani, Arsenio Spinillo, Antonino Ditto, Stefano Bogliolo, Jvan Casarin, Umberto Leone Roberti Maggiore, Fabio Martinelli, Mauro Signorelli, Barbara Gardella, Valentina Chiappa, Cono Scaffa, Simone Ferrero, Antonella Cromi, Domenica Lorusso, Fabio Ghezzi
OBJECTIVE: To evaluate the impact of nerve-sparing (NS) approach on outcomes of patients undergoing minimally invasive radical hysterectomy (MRH) for locally advanced stage cervical cancer (LACC). METHODS: Data of consecutive patients undergoing minimally invasive surgery for LACC were retrospectively retrieved in a multi-institutional setting from 2009 to 2016. All patients included had minimally invasive class III radical hysterectomy (MRH or NS-MRH). Propensity matching algorithm was used to decrease possible allocation bias when comparing outcomes between groups...
September 7, 2017: European Journal of Surgical Oncology
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