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Antonino Ditto, Giorgio Bogani, Umberto Leone Roberti Maggiore, Fabio Martinelli, Valentina Chiappa, Carlos Lopez, Stefania Perotto, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Nerve-sparing radical hysterectomy (NSRH) was introduced with the aim to reduce pelvic dysfunctions related to conventional radical hysterectomy (RH). Here, we sought to assess the effectiveness and safety of NSRH in a relatively large number of the patients of cervical cancer (CC) patients undergoing either primary surgery or neoadjuvant chemotherapy (NACT) followed by surgery. METHODS: Outcomes of consecutive patients undergoing NSRH and of a historical cohort of patients undergoing conventional RH were retrospectively reviewed...
February 28, 2018: Journal of Gynecologic Oncology
Giorgio Bogani, Elena Tagliabue, Mauro Signorelli, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Lavinia Mosca, Ilaria Sabatucci, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To test the applicability of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Memorial Sloan Kettering (MSK) criteria in predicting complete cytoreduction (CC) in patients undergoing secondary cytoreductive surgery (SCS) for recurrent ovarian cancer (ROC). METHODS: Data of consecutive patients undergoing SCS were reviewed. The Arbeitsgemeinschaft Gynäkologische Onkologie OVARian cancer study group (AGO-OVAR) and MSK criteria were retrospectively applied...
February 23, 2018: Journal of Gynecologic Oncology
Giandomenico Maggiore, Maria Silvia Lazio, Oreste Gallo
Olfactory neuroblastoma is a rare malignant tumor of neuroectodermal origin and represents the most common cancer of the nasal cavity in pediatric age. The gold standard of treatment consists of en bloc resection, numerous studies have shown as the endoscopic approaches permit good control of the disease improving the quality of life after the treatment. Herein we describe the case of a 13-year-old patient referred to our outpatient clinic with a polypoid multi-lobed lesion occupying the left nasal cavity and imaging that confirmed a left-sided nasal mass without cribriform plate involvement (Kadish B)...
February 20, 2018: Auris, Nasus, Larynx
Giorgio Bogani, Umberto Leone Roberti Maggiore, Mauro Signorelli, Fabio Martinelli, Antonino Ditto, Ilaria Sabatucci, Lavinia Mosca, Domenica Lorusso, Francesco Raspagliesi
Human papillomavirus (HPV) is the most common sexually transmitted disease, worldwide. Primary prevention thorough vaccination si able to reduce the burden of HPV-related lesions. Ten years ago the Food and drug Administration (FDA) approved the first vaccine against HPV. In the last decades, growing data on safety and effectiveness have been collected. In the present review we report the current knowledge on vaccine against HPV, highlighting the current value and prospective regarding the widespread diffusion of HPV vaccines...
February 2018: Critical Reviews in Oncology/hematology
Paola Ciancetta, Salvatore M Maggiore, Flavia Petrini, Raffaele De Caterina
The correct management of acute heart failure continues to pose diagnostic and therapeutic challenges. In particular, administering the right type and dose of fluids and drugs, thus avoiding fluid overload while establishing organ perfusion, is of key importance in stabilizing critical patients and improving prognosis. A correct estimate of the fluid volume status, however, may be difficult, as the invasive evaluation of cardiac filling pressures by cardiac catheterization is limited in routine medical practice, and there is no universal consensus on the best tools for its non-invasive evaluation...
January 2018: Giornale Italiano di Cardiologia
Maria Sighicelli, Loris Pietrelli, Francesca Lecce, Valentina Iannilli, Mauro Falconieri, Lucia Coscia, Stefania Di Vito, Simone Nuglio, Giorgio Zampetti
Plastic debris incidence in marine environment was already highlighted in the early 1970s. Over the last decade, microplastic pollution in the environment has received increasing attention and is now an emerging research area. Many studies have focused on quantifying microplastic abundance in the marine environment, while there are relatively few data on microplastic occurrence in freshwater environment. Recent studies have reported high concentrations of microplastics in lakes and rivers, although the understanding of several factors influencing source, transport and fate is still limited...
February 9, 2018: Environmental Pollution
C Scala, U Leone Roberti Maggiore, F Barra, P L Venturini, S Ferrero
INTRODUCTION: This patient preference prospective study was designed to compare patients' satisfaction in women with endometriosis treated either by an extended-cycle oral contraception (OC) or by norethindrone acetate (NETA). METHODS: This patient preference prospective study included women of reproductive age with endometriosis. Patients were submitted to one of the following 12 months' treatments: Group A, continuous oral treatment with NETA (2.5 mg/day) and Group B, a 91-day extended-cycle OC (LNG/EE 150/30 mcg for 84 days and EE 10 mcg for 7 days)...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Giorgio Bogani, Francesca Taverna, Claudia Lombardo, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Lavinia Mosca, Ilaria Sabatucci, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To assess the risk of developing high-grade cervical dysplasia among women with low-grade cervical cytology and nonvisible squamocolumnar junction (SCJ) at colposcopic examination. METHODS: Data of consecutive women with low-grade intraepithelial lesion(≤LSIL) undergoing colposcopic examination, which was unsatisfactory (due to the lack of the visualization of the entire SCJ), were retrospectively reviewed. The risk of developing high-grade cervical intraepithelial neoplasia (CIN2+) was assessed using Kaplan-Meier and Cox models...
January 1, 2018: Reproductive Sciences
Silvia Nastasio, Marco Sciveres, Giuseppe Maggiore
No abstract text is available yet for this article.
February 1, 2018: Journal of Pediatric Gastroenterology and Nutrition
Rosario Maggiore, Gianmaria Viglizzo, Corrado Occella, Dario Bleidl, Maria C Coccia, Francesca Manunza
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Francesca Taverna, Claudia Lombardo, Chiara Borghi, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
The objective of this study was to determine whether the pretreatment human papillomavirus (HPV) genotype might predict the risk of cervical dysplasia persistence/recurrence. Retrospective analysis of prospectively collected data of consecutive 5104 women who underwent the HPV-DNA test were matched with retrospective data of women undergoing either follow-up or medical/surgical treatment(s) for genital HPV-related infection(s). Artificial neuronal network (ANN) analysis was used in order to weight the importance of different HPV genotypes in predicting cervical dysplasia persistence/recurrence...
January 22, 2018: European Journal of Cancer Prevention
Lorenzo Colombo, Beatrice Letizia Crippa, Dario Consonni, Maria Enrica Bettinelli, Viola Agosti, Giulia Mangino, Elena Nicoletta Bezze, Paola Agnese Mauri, Lidia Zanotta, Paola Roggero, Laura Plevani, Donatella Bertoli, Maria Lorella Giannì, Fabio Mosca
Breastfeeding is the normative standard for infant feeding. Despite its established benefits, different factors can affect breastfeeding rates over time. The purpose of this study was to evaluate breastfeeding determinants in healthy term newborns during the first three months of life. A prospective, observational, single-center study was conducted in the nursery of Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in Milan, Italy. The mother-baby dyads that were admitted to the Clinic in January and February 2017 were enrolled...
January 5, 2018: Nutrients
Antonella Rossati, Olivia Bargiacchi, Vesselina Kroumova, Claudio Nebbiolo, Maria Grazia Tacca, Sonia Pratillo, Pietro Luigi Garavelli
Hepatitis A (HA) is caused by a hepatovirus from the family Picornaviridae (Hepatitis A Virus, HAV). Transmission occurs mainly by the orofaecal route through food or water contaminated by faeces. Sexual transmission has also been reported among men who have sex with men (MSM). From February to May 2017, 14 patients with HA were hospitalized at the University Hospital "Maggiore della Carità", Novara (Eastern Piedmont), Italy. One patient was two years old and was therefore admitted to the Paediatric Unit, the remaining 13 to the Infectious Disease Unit...
December 1, 2017: Le Infezioni in Medicina
Francesco Callea, Isabella Giovannoni, Sinan Sari, Esendagli Guldal, Buket Dalgic, Gulen Akyol, Tsuyoshi Sogo, Abdulrahman Al-Hussaini, Giuseppe Maggiore, Andrea Bartuli, Renata Boldrini, Paola Francalanci, Emanuele Bellacchio
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage of the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from the Caribbean, Europe, Japan, Saudi Arabia, Turkey, and China. All reported children presented with a variable degree of histologically proven chronic liver disease and low plasma fibrinogen levels. In addition, one Japanese and one Turkish child had concomitant hypo-APOB-lipoproteinemia of unknown origin...
December 15, 2017: International Journal of Molecular Sciences
Dalila Mele, Grazia Bossi, Giuseppe Maggiore, Barbara Oliviero, Stefania Mantovani, Beatrice Bonelli, Mario U Mondelli, Stefania Varchetta
Type 2 autoimmune hepatitis (AIH-2) is a rare disease presenting in early childhood. The immunopathogenetic mechanisms are poorly characterized, although a defect of regulatory T cells (Treg) has been shown. There is virtually no information on innate immune responses and natural killer (NK) cells in particular. We have performed an extended immunophenotypic and functional analysis of NK cells in children with AIH-2. We show that NK cell frequency is reduced in this setting and that the balance between NK activating and inhibitory receptors is skewed toward activation...
March 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Paolo Vercellini, Maria Pina Frattaruolo, Riccardo Rosati, Dhouha Dridi, Anna Roberto, Paola Mosconi, Olga De Giorgi, Fulvia Milena Cribiù, Edgardo Somigliana
STUDY QUESTION: What is the degree of patient satisfaction in women with symptomatic colorectal endometriosis who choose medical or surgical treatment after a shared decision-making (SDM) process? SUMMARY ANSWER: The degree of satisfaction with treatment was high both in women who chose medical treatment with a low-dose oral contraceptive (OCP) or a progestin, and in those who chose to undergo surgical resection of bowel endometriosis. WHAT IS KNOWN ALREADY: Hormonal therapies and surgery for colorectal endometriosis have been investigated in non-comparative studies with inconsistent results...
February 1, 2018: Human Reproduction
Umberto Leone Roberti Maggiore, Simone Ferrero
No abstract text is available yet for this article.
March 2018: Menopause: the Journal of the North American Menopause Society
Federico Longhini, Davide Colombo, Lara Pisani, Francesco Idone, Pan Chun, Jonne Doorduin, Liu Ling, Moreno Alemani, Andrea Bruni, Jin Zhaochen, Yu Tao, Weihua Lu, Eugenio Garofalo, Luca Carenzo, Salvatore Maurizio Maggiore, Haibo Qiu, Leo Heunks, Massimo Antonelli, Stefano Nava, Paolo Navalesi
The objective of this study was to assess ability to identify asynchronies during noninvasive ventilation (NIV) through ventilator waveforms according to experience and interface, and to ascertain the influence of breathing pattern and respiratory drive on sensitivity and prevalence of asynchronies. 35 expert and 35 nonexpert physicians evaluated 40 5-min NIV reports displaying flow-time and airway pressure-time tracings; identified asynchronies were compared with those ascertained by three examiners who evaluated the same reports displaying, additionally, tracings of diaphragm electrical activity...
October 2017: ERJ Open Research
Umberto Leone Roberti Maggiore, Annalisa Inversetti, Matteo Schimberni, Paola Viganò, Veronica Giorgione, Massimo Candiani
Over the past few years, a new topic in the field of endometriosis has emerged: the potential impact of the disease on pregnancy outcomes. This review aims to summarize in detail the available evidence on the relationship between endometriosis, particularly deep endometriosis (DE), and obstetrical outcomes. Acute complications of DE, such as spontaneous hemoperitoneum, bowel perforation, and uterine rupture, may occur during pregnancy. Although these events represent life-threatening conditions, they are rare and unpredictable...
December 2017: Fertility and Sterility
Giorgio Bogani, Diego Oreste Rossetti, Antonino Ditto, Mauro Signorelli, Fabio Martinelli, Lavinia Mosca, Cono Scaffa, Umberto Leone Roberti Maggiore, Valentina Chiappa, Ilaria Sabatucci, Domenica Lorusso, Francesco Raspagliesi
Few studies have investigated the efficacy and safety of the nerve-sparing approach via minimally invasive surgery for the treatment of cervical cancer. We aimed to review the current evidence comparing nerve-sparing minimally invasive radical hysterectomy (NS-MRH) with conventional minimally invasive radical hysterectomy (MRH). This systematic review was registered in the International Prospective Register of Systematic Reviews (CRD#57655). Overall, 675 patients were included: 350 (51.9%) and 325 (48.1%) patients undergoing MRH and NS-MRH, respectively...
March 2018: Journal of Minimally Invasive Gynecology
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