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https://www.readbyqxmd.com/read/29771248/-i-direttori-delle-riviste-vanno-avanti-attenersi-ai-principi-accademici-adottare-trasparenza-e-rispetto-e-applicare-le-regole
#1
Jaime A Teixeira da Silva, Judit Dobránszki
Nonostante i cambiamenti in corso nell'ambito delle pubblicazioni scientifiche (STEM - scienza, tecnologia, ingegneria e medicina), è indubbio che i direttori delle riviste restano i più importanti custodi del processo editoriale. In questo articolo vengono analizzati i motivi per cui i direttori delle riviste devono continuare ad attenersi ai principi editoriali fondamentali e a utilizzare le nuove tecnologie digitali solo per dare forza al contenuto, ma non per sostituirlo nella sua qualità. Per raggiungere questo obiettivo, in un'epoca caratterizzata da controlli ed equilibri, i direttori delle riviste devono essere attentamente sorvegliati e ritenuti responsabili tanto quanto gli autori che essi stessi valutano...
May 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29766815/old-and-new-treatments-for-pediatric-autoimmune-hepatitis
#2
Silvia Nastasio, Giuseppe Maggiore, Marco Sciveres, Lorenza Matarazzo
Autoimmune hepatitis is a rare inflammatory disease of the liver that most frequently affects children and young adults. It is a multifactorial disease of unknown etiology, characteristically progressive in nature, and if left untreated, may lead to cirrhosis and terminal liver failure. It has been known for several decades now that immunosuppressive treatment convincingly alters the outcome of most patients with autoimmune hepatitis and as such it should be started as soon as diagnosis is made. Primary goals of treatment are: normalization of hepatocellular function, extinction of the hepatic necroinflammatory process, and maintenance of a stable remission, thus preventing progression to cirrhosis and its complications...
May 16, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29759566/role-of-bevacizumab-in-uterine-leiomyosarcoma
#3
REVIEW
Giorgio Bogani, Antonino Ditto, Fabio Martineli, Mauro Signorelli, Valentina Chiappa, Caterina Fonatella, Roberta Sanfilippo, Umberto Leone Roberti Maggiore, Simone Ferrero, Domenica Lorusso, Francesco Raspagliesi
In the recent years, angiogenetic inhibitors have emerged for the treatment of several malignancies. In particular, bevacizumab has proved to be effective in many types of cancers (including sarcoma), but the limitations of antiangiogenic therapy have been shown in practice. Here, we sought to review the current evidence on the role and efficacy of bevacizumab in patients affected by uterine leiomyosarcoma. On April 2017, Literature was searched in order to identify studies reporting outcomes of patients affected either by early stage or advanced/recurred uterine leiomyosarcoma undergoing treatment with bevacizumab, alone or in combination with other chemotherapeutic regimens...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29756652/laser-treatment-for-women-with-high-grade-vaginal-intraepithelial-neoplasia-a-propensity-matched-analysis-on-the-efficacy-of-ablative-versus-excisional-procedures
#4
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Lavinia Mosca, Valentina Chiappa, Diego Rossetti, Umberto Leone Roberti Maggiore, Ilaria Sabatrucci, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To investigate the long-term effectiveness of LASER treatment in women affected by high-grade vaginal intra-epithelial neoplasia. METHODS: Data of consecutive women treated for high-grade vaginal intra-epithelial neoplasia were retrieved. Efficacy and long-term effectiveness of ablative and excisional procedures were tested using a propensity-matched algorithm. Risk of recurrence over the time was assessed using Kaplan-Meier and Cox models. RESULTS: Overall, 204 patients met the inclusion criteria...
May 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29739278/living-alone-and-dementia-incidence-a-clinical-based-study-in-people-with-mild-cognitive-impairment
#5
Giulia Grande, Davide Liborio Vetrano, Ilaria Cova, Simone Pomati, Daniele Mattavelli, Laura Maggiore, Valentina Cucumo, Roberta Ghiretti, Nicola Vanacore, Claudio Mariani, Debora Rizzuto
INTRODUCTION: Social isolation and living alone have been associated with negative outcomes, especially in the older population. We aim to investigate the effect of living alone on the development of dementia in people with mild cognitive impairment (MCI). MATERIALS AND METHODS: In this longitudinal study, we enrolled 345 outpatients with MCI evaluated at baseline through a clinical and neuropsychological protocol. Data on living situation (living alone vs. living with someone) were also collected...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29723971/assessment-of-lactose-free-diet-on-the-phalangeal-bone-mineral-status-in-italian-adolescents-affected-by-adult-type-hypolactasia
#6
Alessandro Baldan, Sylvie Tagliati, Daniela Saccomandi, Andrea Brusaferro, Laura Busoli, Andrea Scala, Cristina Malaventura, Giuseppe Maggiore, Caterina Borgna-Pignatti
Adult-type hypolactasia (ATH) is a clinical syndrome of primary lactase deficiency. A lactose-free diet is advisable to avoid the symptoms linked to the condition, but this potentially creates problems for optimal bone mineralization due to reduced calcium intake. To evaluate the effect of the lactose-free diet on the bone mineral status (BMS), we compared the phalangeal BMS of adolescents with ATH to that of peers on a normal diet. Also, we analyzed the correlations between BMS and dietary behavior, physical exercise, and calcium and vitamin D intake...
May 1, 2018: Nutrients
https://www.readbyqxmd.com/read/29705872/factors-associated-with-falls-in-older-adults-with-cancer-a-validated-model-from-the-cancer-and-aging-research-group
#7
Tanya M Wildes, Ronald J Maggiore, William P Tew, David Smith, Can-Lan Sun, Harvey Cohen, Supriya G Mohile, Ajeet Gajra, Heidi D Klepin, Cynthia Owusu, Cary P Gross, Hyman Muss, Andrew Chapman, Stuart M Lichtman, Vani Katheria, Arti Hurria
BACKGROUND: Falls in older adults with cancer are common, yet factors associated with fall-risk are not well-defined and may differ from the general geriatric population. This study aims to develop and validate a model of factors associated with prior falls among older adults with cancer. METHODS: In this cross-sectional secondary analysis, two cohorts of patients aged ≥ 65 with cancer were examined to develop and validate a model of factors associated with falls in the prior 6 months...
April 28, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29702702/interaction-of-healthcare-staff-s-attitude-with-barriers-to-physical-activity-in-hemodialysis-patients-a-quantitative-assessment
#8
Giuseppe Regolisti, Umberto Maggiore, Alice Sabatino, Ilaria Gandolfini, Sarah Pioli, Claudia Torino, Filippo Aucella, Adamasco Cupisti, Valentina Pistolesi, Alessandro Capitanini, Giorgia Caloro, Mariacristina Gregorini, Yuri Battaglia, Marcora Mandreoli, Lucia Dani, Giovanni Mosconi, Vincenzo Bellizzi, Biagio Raffaele Di Iorio, Paolo Conti, Enrico Fiaccadori
BACKGROUND AND AIM OF THE STUDY: In hemodialysis patients, sedentarism is a potentially modifiable mortality risk factor. We explored whether healthcare staff's attitude towards exercise interacts with patient-perceived barriers in modifying the level of physical activity in this population. METHODS: In this prospective, cross-sectional, multicenter study we recruited 608 adult patients and 330 members of the healthcare staff in 16 hemodialysis units in Italy. We assessed patient-perceived barriers to, and healthcare staff's attitude towards, exercise by specific questionnaires...
2018: PloS One
https://www.readbyqxmd.com/read/29683876/factors-predictive-of-90-day-morbidity-readmission-and-costs-in-patients-undergoing-pelvic-exenteration
#9
Giorgio Bogani, Mauro Signorelli, Antonino Ditto, Fabio Martinelli, Jvan Casarin, Lavinia Mosca, Umberto Leone Roberti Maggiore, Valentina Chiappa, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Pelvic exenteration for recurrent gynecological malignancies is characterized by a high rate of severe complications. Factors predictive of morbidity, readmission, and cost were analyzed. METHODS: Data of consecutive patients undergoing pelvic exenteration between January 2007 and December 2016 were prospectively evaluated. RESULTS: Fifty-eight patients were included in the analysis. Anterior, posterior, and total exenterations were executed in 39 (67%), 9 (16%), and 10 (17%) patients, respectively...
April 21, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29674775/-gestione-dei-pazienti-psichiatrici-prima-della-deistituzionalizzazione-un-indagine-della-clinica-di-pisa-fra-1907-e-1913
#10
Dario Muti, Barbara Carpita, Elisa Diadema, Gabriele Massimetti, Luciano Conti, Claudia Carmassi, Liliana Dell'Osso
RIASSUNTO. Scopo. La maggior parte della ricerca storiografica sulla psichiatria agli inizi del ventesimo secolo prende principalmente in considerazione l'istituzione manicomiale. Per indagare le caratteristiche di internamento in una popolazione clinica, abbiamo analizzato i registri clinici, recentemente resi disponibili, della Clinica di Malattie Nervose e Mentali dell'Università di Pisa, prendendo in considerazione tutte le ammissioni dal 24 aprile 1907 al 31 gennaio 1913. Metodo. Sono stati raccolti dati demografici e clinici di 1068 pazienti, effettuando test del Chi Quadrato per elicitare la correlazione fra trasferimento manicomiale e differenza di genere; inoltre sono stati effettuati T-Test per confrontare la media di età, la media di giorni di ospedalizzazione e la media di ricoveri successivi nei pazienti trasferiti in manicomio e in quelli licenziati...
March 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29652184/dioxin-like-compounds-in-lake-fish-species-evaluation-by-dr-calux-bioassay
#11
S Sciuto, M Prearo, R Desiato, C Bulfon, E A V Burioli, G Esposito, C Guglielmetti, L Dell'atti, G Ru, D Volpatti, P L Acutis, F Martucci
Fish consumption is the principal source of intake of organochlorinated compounds in humans. Compared with other types of foods of animal origin, fish contain the highest levels of polychlorinated biphenyls (PCBs), polychlorinated dibenzo- p-dioxins, and polychlorinated dibenzofurans, all of which are classified as highly toxic organochlorine compounds. Currently, lakes and fish farms in northern Italy are not regularly monitored for PCBs and dioxins in areas contaminated by industrial sources, partially because of the high costs of traditional analytical methods that limit the number of samples to be analyzed...
April 13, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29623525/what-are-the-caregivers-needs-on-dementia-care-an-integrated-qualitative-and-quantitative-assessment
#12
Ilaria Cova, N Travi, L Maggiore, V Cucumo, C Mariani, S Pomati
Dementia is one of the main causes of disability later in life. Interventions in support of patients with dementia aim at granting the highest level of independence in activities of daily living and at delivering the required facilities; formal and informal caregivers represent the interface between patients and health services. The aims of our study were to assess caregivers' perceived needs and to relate them to their own socio-cultural features and to patients' clinical characteristics. During three consecutive months, 50 caregivers of patients with dementia were interviewed about their needs in the assistance of subjects with dementia by means of three structured questionnaires (Caregiver Needs Assessment [CNA], Zarit Burden Inventory [ZBI], Neuropsychiatric Inventory-Questionnaire [NPI-Q]) and of two open-ended questions...
April 5, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29621388/findings-linking-mismatch-repair-mutation-with-age-at-endometrial-and-ovarian-cancer-onset-in-lynch-syndrome
#13
Giorgio Bogani, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
No abstract text is available yet for this article.
April 5, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29608967/time-to-treatment-failure-and-related-outcomes-among-1000-advanced-non-small-cell-lung-cancer-patients-comparisons-between-older-versus-younger-patients
#14
Ajeet Gajra, Tyler J Zemla, Aminah Jatoi, Josephine L Feliciano, Melisa L Wong, Hongbin Chen, Ronald Maggiore, Ryan P McMurray, Arti Hurria, Hyman B Muss, Harvey J Cohen, Jacqueline Lafky, Martin J Edelman, Rogerio Lilenbaum, Jennifer G Le-Rademacher
BACKGROUND: Time-to-treatment-failure (TTF) is the interval from chemotherapy initiation to premature discontinuation. We evaluated TTF based on age. METHODS: Pooled analyses were conducted with, first-line chemotherapy trials for advanced non-small cell lung cancer (CALGB 9730, 30203, and 30801). Comparisons -- with age 65+ and 70+ years -- were performed for TTF (primary endpoint), reasons for early chemotherapy cessation, grade 3+ adverse events, and overall survival...
March 30, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29596183/chapter-6-2-immune-function-related-liver-disease-and-espghan-s-contribution-to-the-advancement-of-science-in-the-last-3-decades
#15
Anil Dhawan, Giorgina Mieli-Vergani, Diego Vergani, Nedim Hadzic, Giuseppe Maggiore
No abstract text is available yet for this article.
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29596180/chapter-6-espghan-s-contributions-to-paediatric-hepatology
#16
Martin Burdelski, Etienne Sokal, Pilar Nannini, Anil Dhawan, Giorgina Mieli-Vergani, Diego Vergani, Nedim Hadzic, Giussepe Maggiore, Pietro Vajro, Giulia Paolella, Giovanna Alfano, Roderick Houwen, Deirdre Kelly
No abstract text is available yet for this article.
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29570177/multifocal-skin-tuberculosis-report-of-a-case
#17
Cristina Malaventura, Anna Bulian, Euro Cacciatore, Elisa Fiumana, Maria Rita Govoni, Giuseppe Maggiore, Caterina Borgna-Pignatti
Tuberculosis is a severe problem in underdeveloped countries. Cutaneous tuberculosis is rare and often goes unrecognized. We report a Pakistani child with multifocal cutaneous and pulmonary tuberculosis. Microbiologic diagnosis was obtained when the abscesses were biopsied. Four-drug therapy produced rapid improvement of the lesions.A high level of suspicion must be maintained when evaluating children from countries at risk.
March 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29563546/preclinical-development-of-a-novel-orally-administered-anti-tumour-necrosis-factor-domain-antibody-for-the-treatment-of-inflammatory-bowel-disease
#18
J Scott Crowe, Kevin J Roberts, Timothy M Carlton, Luana Maggiore, Marion F Cubitt, Simon Clare, Katherine Harcourt, Jill Reckless, Thomas T MacDonald, Keith P Ray, Anna Vossenkämper, Michael R West
TNFα is an important cytokine in inflammatory bowel disease. V565 is a novel anti-TNFα domain antibody developed for oral administration in IBD patients, derived from a llama domain antibody and engineered to enhance intestinal protease resistance. V565 activity was evaluated in TNFα-TNFα receptor-binding ELISAs as well as TNFα responsive cellular assays and demonstrated neutralisation of both soluble and membrane TNFα with potencies similar to those of adalimumab. Although sensitive to pepsin, V565 retained activity after lengthy incubations with trypsin, chymotrypsin, and pancreatin, as well as mouse small intestinal and human ileal and faecal supernatants...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29533024/oncologic-effectiveness-of-nerve-sparing-radical-hysterectomy-in-cervical-cancer
#19
Antonino Ditto, Giorgio Bogani, Umberto Leone Roberti Maggiore, Fabio Martinelli, Valentina Chiappa, Carlos Lopez, Stefania Perotto, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Nerve-sparing radical hysterectomy (NSRH) was introduced with the aim to reduce pelvic dysfunctions related to conventional radical hysterectomy (RH). Here, we sought to assess the effectiveness and safety of NSRH in a relatively large number of the patients of cervical cancer (CC) patients undergoing either primary surgery or neoadjuvant chemotherapy (NACT) followed by surgery. METHODS: Outcomes of consecutive patients undergoing NSRH and of a historical cohort of patients undergoing conventional RH were retrospectively reviewed...
February 28, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29533023/a-score-system-for-complete-cytoreduction-in-selected-recurrent-ovarian-cancer-patients-undergoing-secondary-cytoreductive-surgery-predictors-and-nomogram-based-analyses
#20
Giorgio Bogani, Elena Tagliabue, Mauro Signorelli, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Lavinia Mosca, Ilaria Sabatucci, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To test the applicability of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Memorial Sloan Kettering (MSK) criteria in predicting complete cytoreduction (CC) in patients undergoing secondary cytoreductive surgery (SCS) for recurrent ovarian cancer (ROC). METHODS: Data of consecutive patients undergoing SCS were reviewed. The Arbeitsgemeinschaft Gynäkologische Onkologie OVARian cancer study group (AGO-OVAR) and MSK criteria were retrospectively applied...
February 23, 2018: Journal of Gynecologic Oncology
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