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https://www.readbyqxmd.com/read/28323222/laparoscopic-nerve-preserving-sacropexy
#1
Alfredo Ercoli, Stefano Cosma, Francesca Riboni, Giuseppe Campagna, Paolo Petruzzelli, Daniela Surico, Saverio Danese, Giovanni Scambia, Chiara Benedetto
STUDY OBJECTIVE: to demonstrate our developed nerve preserving technique during laparoscopic sacropexy (LSP) for multicompartment pelvic organ prolapse. DESIGN: exemplificative case of our surgical procedure based on a multicentric experience consisting of more than 800 cases in 10 years without major intraoperative complications. Informed consent was taken from the subject, and the institutional review board approved this research. SETTING: public practice at Maggiore della Carità University Hospital, Novara; at Sant'Anna Hospital, City of Health and Science, University of Torino; at A...
March 17, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28302753/erythropoietin-receptor-mediated-molecular-crosstalk-promotes-t-cell-immunoregulation-and-transplant-survival
#2
Carolina Purroy, Robert L Fairchild, Toshiaki Tanaka, William M Baldwin, Joaquin Manrique, Joren C Madsen, Robert B Colvin, Alessandro Alessandrini, Bruce R Blazar, Miguel Fribourg, Chiara Donadei, Umberto Maggiore, Peter S Heeger, Paolo Cravedi
Although spontaneous kidney transplant acceptance/tolerance occurs in mice and occasionally in humans, mechanisms remain unclear. Herein we test the hypothesis that EPO, a hormone predominantly produced by the adult kidney, has immunomodulating properties that are required for spontaneous kidney graft acceptance. In vitro, in a manner dependent on the EPO receptor and CD131 on antigen-presenting cells, EPO induced the secretion of active TGFβ by antigen-presenting cells, which in turn converted naïve CD4(+) T cells into functional Foxp3(+) regulatory T cells (Treg)...
March 16, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28287193/medico-legal-notes-for-a-new-set-of-standards-in-the-assessment-of-penal-liability-in-psychiatry
#3
Gianluca Montanari Vergallo, Raffaella Rinaldi, Giuseppe Bersani, Enrico Marinelli
Negligence liability on the part of a psychiatrist belongs among high-complexity fields, for both the judge and his or her technical consultants. In most instances, there are no scientific grounds in order to ascribe with reasonable certainty liability to medical personnel and nursing staff, while often judges tend to stretch the concept of “protection” to a degree to which the psychiatrist is deemed to have a legal obligation to stave off the development of any adverse consequence which psychic distress may bring upon the patient...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28286192/endoscopic-and-histologic-healing-in-children-with-inflammatory-bowel-diseases-treated-with-thalidomide
#4
Marzia Lazzerini, Vincenzo Villanacci, Maria Chiara Pellegrin, Stefano Martelossi, Giuseppe Magazzù, Salvatore Pellegrino, Maria Cristina Lucanto, Arrigo Barabino, Angela Calvi, Serena Arrigo, Paolo Lionetti, Massimo Fontana, Giovanna Zuin, Giuseppe Maggiore, Matteo Bramuzzo, Massimo Maschio, Marianna Salemme, Stefania Manenti, Lorenzi Luisa, Giuliana Decorti, Marcella Montico, Alessandro Ventura
BACKGROUND & AIMS: Mucosal healing, determined by endoscopic evaluation, is one of the most important prognostic markers for patients with inflammatory bowel diseases. Findings from histologic evaluation, however, could complement findings from endoscopy in assessing mucosal responses to treatment. We analyzed long term results of children treated with thalidomide to determine the association between clinical response and histology and endoscopy findings. METHODS: We collected data from 2 multi-center trials of 70 children with refractory Crohn's disease (CD) or ulcerative colitis (UC) (2-18 years old; ileo-colonic or colonic disease) given thalidomide or placebo (NCT00720538)...
March 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28274154/investigational-drugs-for-the-treatment-of-cervical-cancer
#5
Fabio Barra, Domenica Lorusso, Umberto Leone Roberti Maggiore, Antonino Ditto, Giorgio Bogani, Francesco Raspagliesi, Simone Ferrero
Cervical cancer (CC) is currently the fourth most common malignant disease of women worldwide. Although the incidence and the mortality rates have been decreasing with screening detection and new treatment strategies, a significant number of metastatic or recurrent disease is still diagnosed. For those patients not amenable to curative treatments, such as surgery and radiation, palliative chemotherapy remains the standard of care. As chemotherapy regimens have limited activity, research is focalized on investigating novel pharmacologic strategies...
March 8, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28267072/an-attempt-to-determine-the-prevalence-of-two-inborn-errors-of-primary-bile-acid-synthesis-results-of-a-european-survey
#6
Jörg Jahnel, Evelyn Zöhrer, Björn Fischler, Lorenzo D'Antiga, Dominique Debray, Antal Dezsofi, Dorothea Haas, Nedim Hadzic, Emmanuel Jacquemin, Thierry Lamireau, Giuseppe Maggiore, Pat J McKiernan, Pier Luigi Calvo, Henkjan J Verkade, Loreto Hierro, Valerie McLin, Ulrich Baumann, Emmanuel Gonzales
OBJECTIVE: Inborn errors of primary bile acid (BA) synthesis are genetic cholestatic disorders leading to accumulation of atypical BA with deficiency of normal BA. Unless treated with primary BA, chronic liver disease usually progresses to cirrhosis and liver failure before adulthood. We sought to determine the prevalence of two common disorders, 3β-hydroxy-Δ-C27-steroid dehydrogenase (3β-HSD) and Δ-3-oxosteroid-5β-reductase (Δ-3-oxoR) deficiencies and to describe current diagnostic and treatment strategies among different European paediatric hepatology centres...
March 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28252907/-italian-male-nurses-called-to-arms-in-world-war-ii-the-letters-of-the-years-of-imprisonment
#7
Rosa Maria Gaetano, Roberto Milos, Ivana Maria Rossi, Stefania Rancati
AIM: During the Second World War the male staff of assistance in the Italia hospitals was called to arms.This work concerns the letters sent by the male nurses who were captured by the Germans and put in prison. The aim is to know whether their profession had somehow affected their living condition in jail and had favoured their release or not. METHOD: 88 personal files of nurses on duty in Ospedale Maggiore and sent to the front during the period between 1940 and 1945 have been studied...
October 2016: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28244579/prevention-of-healthcare-associated-infections-a-descriptive-study
#8
R Accardi, S Castaldi, A Marzullo, S Ronchi, D Laquintana, M Lusignani
BACKGROUND: This study aims to verify whether there are, and to which degree, knowledge and adherence to guidelines on the prevention and control of healthcare associated infections by nursing staff. Study design. A descriptive study was conducted on a sample of nurses in the areas of medicine, surgery, and its own specialties of the Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico in Milan from 1st December 2015 to 29th February 2016. METHODS: The knowledge of the nursing staff have been investigated through the use of questionnaires with anonymous self-reporting method; inspections in the wards using observational grids were carried out in order to verify adherence to best-practice principles...
March 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28223182/minimally-invasive-surgical-staging-in-early-stage-ovarian-carcinoma-a-systematic-review-and-meta-analysis
#9
REVIEW
Giorgio Bogani, Chiara Borghi, Umberto Leone Roberti Maggiore, Antonino Ditto, Mauro Signorelli, Fabio Martinelli, Valentina Chiappa, Carlos Lopez, Ilaria Sabatucci, Cono Scaffa, Alice Indini, Simone Ferrero, Domenica Lorusso, Francesco Raspagliesi
Few studies investigated the efficacy and safety of minimally invasive surgery (MIS) for the treatment of early stage epithelial ovarian cancer (eEOC). In this context, we aimed to review the current evidence comparing laparoscopy and laparotomic approach for staging procedures in eEOC This systematic review was registered in the International Prospective Register of Systematic Review. Overall, 3,065 patients were included: 1,450 undergoing laparoscopy and 1,615 undergoing laparotomic staging. Patients undergoing laparoscopy experienced a longer (but not statistically significant) operative time (WMD: 28...
February 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28213926/association-of-hypercalcemia-before-treatment-with-hypocalcemia-after-treatment-in-dogs-with-primary-hyperparathyroidism
#10
J D Dear, P H Kass, A M Della Maggiore, E C Feldman
BACKGROUND: Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures. HYPOTHESIS/OBJECTIVES: The objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28213797/long-term-outcomes-of-tot-and-tvt-procedures-for-the-treatment-of-female-stress-urinary-incontinence-a-systematic-review-and-meta-analysis
#11
REVIEW
Umberto Leone Roberti Maggiore, Enrico Finazzi Agrò, Marco Soligo, Vincenzo Li Marzi, Alex Digesu, Maurizio Serati
INTRODUCTION AND HYPOTHESES: One of the most relevant topics in the field of pelvic floor dysfunction treatment is the long-term efficacy of surgical procedures, in particular, the use of prosthesis. Hence, a systematic review and meta-analysis was conducted to evaluate the long-term effectiveness and safety of midurethral sling (MUS) procedures for stress urinary incontinence (SUI), as reported in randomised controlled trials (RCTs) and non-randomised studies. METHODS: This systematic review is based on material searched and obtained via PubMed/Medline, Scopus, and the Cochrane Library between January 2000 and October 2016...
February 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28187148/nutritional-status-and-body-composition-by-bioelectrical-impedance-vector-analysis-a-cross-sectional-study-in-mild-cognitive-impairment-and-alzheimer-s-disease
#12
Ilaria Cova, Simone Pomati, Laura Maggiore, Marica Forcella, Valentina Cucumo, Roberta Ghiretti, Giulia Grande, Fulvio Muzio, Claudio Mariani
AIMS: Analysis of nutritional status and body composition in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). METHODS: A cross-sectional study was performed in a University-Hospital setting, recruiting 59 patients with AD, 34 subjects with MCI and 58 elderly healthy controls (HC). Nutritional status was assessed by anthropometric parameters (body mass index; calf, upper arm and waist circumferences), Mini Nutritional Assessment (MNA) and body composition by bioelectrical impedance vector analysis (BIVA)...
2017: PloS One
https://www.readbyqxmd.com/read/28186535/long-term-risks-of-kidney-living-donation-review-and-position-paper-by-the-era-edta-descartes-working-group
#13
Umberto Maggiore, Klemens Budde, Uwe Heemann, Luuk Hilbrands, Rainer Oberbauer, Gabriel C Oniscu, Julio Pascual, Soren Schwartz Sorensen, Ondrej Viklicky, Daniel Abramowicz
No abstract text is available yet for this article.
February 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28178576/the-association-of-pre-treatment-hpv-subtypes-with-recurrence-of-vin
#14
Giorgio Bogani, Fabio Martinelli, Antonino Ditto, Mauro Signorelli, Francesca Taverna, Claudia Lombardo, Valentina Chiappa, Umberto Leone Roberti Maggiore, Dario Recalcati, Cono Scaffa, Stefania Perotto, Ilaria Sabatucci, Alice Indini, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To assess whether pre-treatment HPV types are associated with recurrence of high-grade vulvar intraepithelial neoplasia (VIN2+). STUDY DESIGN: Data of consecutive patients with pretreatment HPV DNA test undergoing treatment for VIN2+ were retrospectively collected. Risk factors promoting the risk of VIN2+ persistence and recurrence were analyzed using Kaplan-Meier and Cox hazard proportional models. RESULTS: 64 patients had pretreatment vulvar-vaginal HPV DNA test...
February 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28129238/impact-of-blood-transfusions-on-survival-of-locally-advanced-cervical-cancer-patients-undergoing-neoadjuvant-chemotherapy-plus-radical-surgery
#15
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Carlos Lopez, Alice Indini, Umberto Leone Roberti Maggiore, Ilaria Sabatucci, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Transfusions represent one of the main progresses of modern medicine. However, accumulating evidence supports that transfusions correlate with worse survival outcomes in patients affected by solid cancers. In the present study, we aimed to investigate the effects of perioperative blood transfusion in locally advanced cervical cancer. METHODS: Data of consecutive patients affected by locally advanced cervical cancer scheduled to undergo neoadjuvant chemotherapy plus radical surgery were retrospectively searched to test the impact of perioperative transfusions on survival outcomes...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28108768/severe-hypercapnia-and-outcome-of-mechanically-ventilated-patients-with-moderate-or-severe-acute-respiratory-distress-syndrome
#16
Nicolas Nin, Alfonso Muriel, Oscar Peñuelas, Laurent Brochard, José Angel Lorente, Niall D Ferguson, Konstantinos Raymondos, Fernando Ríos, Damian A Violi, Arnaud W Thille, Marco González, Asisclo J Villagomez, Javier Hurtado, Andrew R Davies, Bin Du, Salvatore M Maggiore, Luis Soto, Gabriel D'Empaire, Dimitrios Matamis, Fekri Abroug, Rui P Moreno, Marco Antonio Soares, Yaseen Arabi, Freddy Sandi, Manuel Jibaja, Pravin Amin, Younsuck Koh, Michael A Kuiper, Hans-Henrik Bülow, Amine Ali Zeggwagh, Antonio Anzueto, Jacob I Sznajder, Andres Esteban
PURPOSE: To analyze the relationship between hypercapnia developing within the first 48 h after the start of mechanical ventilation and outcome in patients with acute respiratory distress syndrome (ARDS). PATIENTS AND METHODS: We performed a secondary analysis of three prospective non-interventional cohort studies focusing on ARDS patients from 927 intensive care units (ICUs) in 40 countries. These patients received mechanical ventilation for more than 12 h during 1-month periods in 1998, 2004, and 2010...
February 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28089477/bioimpedance-and-fluid-status-in-children-and-adolescents-treated-with-dialysis
#17
Gregorio P Milani, Jaap W Groothoff, Federica A Vianello, Emilio F Fossali, Fabio Paglialonga, Alberto Edefonti, Carlo Agostoni, Dario Consonni, Dewi van Harskamp, Johannes B van Goudoever, Henk Schierbeek, Michiel J S Oosterveld
BACKGROUND: Assessment of hydration status in patients with chronic kidney failure treated by dialysis is crucial for clinical management decisions. Dilution techniques are considered the gold standard for measurement of body fluid volumes, but they are unfit for day-to-day care. Multifrequency bioimpedance has been shown to be of help in clinical practice in adults and its use in children and adolescents has been advocated. We investigated whether application of multifrequency bioimpedance is appropriate for total-body water (TBW) and extracellular water (ECW) measurement in children and adolescents on dialysis therapy...
March 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28078809/three-year-analysis-of-repeated-laboratory-tests-for-the-markers-total-cholesterol-ferritin-vitamin-d-vitamin-b12-and-folate-in-a-large-research-and-teaching-hospital-in-italy
#18
Monica Lanzoni, Marco Fornili, Irene Felicetta, Rita Maiavacca, Elia Biganzoli, Silvana Castaldi
RATIONALE, AIMS AND OBJECTIVES: The increasing number of diagnostic tests requests all over the world is a problem that can partially be explained by inappropriate testing. Impact on the total costs of health systems becomes relevant when tests are performed in a large amount. In this paper, retesting of total cholesterol, ferritin, vitamin B12 , vitamin D, and folate is assessed. METHODS: The Quality Unit of Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano (Fondazione) decided to perform a first assessment of the appropriate use of the laboratory tests cholesterol, ferritin, vitamin B12 , vitamin D, and folate focusing on the retesting interval for the same patient in the time period January 1, 2012, to December 31, 2014, in every care setting...
January 12, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28040358/bladder-endometriosis-a-systematic-review-of-pathogenesis-diagnosis-treatment-impact-on-fertility-and-risk-of-malignant-transformation
#19
REVIEW
Umberto Leone Roberti Maggiore, Simone Ferrero, Massimo Candiani, Edgardo Somigliana, Paola Viganò, Paolo Vercellini
CONTEXT: The bladder is the most common site affected in urinary tract endometriosis. There is controversy regarding the pathogenesis, clinical management (diagnosis and treatment), impact on fertility, and risk of malignant transformation of bladder endometriosis (BE). OBJECTIVE: To systematically evaluate evidence regarding the pathogenesis, diagnosis, medical and surgical treatment, impact on female fertility, and risk of malignant transformation of BE. EVIDENCE ACQUISITION: A systematic review of PubMed/Medline from inception until October 2016 was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and was registered in the PROSPERO registry (www...
December 28, 2016: European Urology
https://www.readbyqxmd.com/read/28039759/human-papillomavirus-hpv-persistence-and-hpv-31-predict-the-risk-of-recurrence-in-high-grade-vaginal-intraepithelial-neoplasia
#20
Giorgio Bogani, Fabio Martinelli, Antonino Ditto, Francesca Taverna, Claudia Lombardo, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Caterina Fontanella, Ilaria Sabatucci, Chiara Borghi, Dario Recalcati, Alice Indini, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: High-grade vaginal intraepithelial neoplasia (vaginal HSIL) represents an uncommon entity. Here, we sought to identify predictors for recurrence and risk factor for developing genital cancers after primary treatment for vaginal HSIL. METHODS: Data of consecutive 5104 women who had human papillomavirus (HPV) DNA test were searched for identify women with histological confirmed vaginal HSIL. Disease-free interval and the risk of developing HPV-related gynecological cancers were assessed using Kaplan-Meier and Cox proportional hazard models...
December 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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