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https://www.readbyqxmd.com/read/28231044/original-research-paper-switching-antipsychotics-results-of-16-month-non-interventional-prospective-observational-clinical-research-of-inpatients-with-schizophrenia-spectrum-disorders
#1
Cvetka Bačar Bole, Mitja Pišlar, Metka Šen, Rok Tavčar, Aleš Mrhar
The study aims to identify prescribing and switching patterns of antipsychotics in clinical practice. A 16-month, prospective study was conducted at the Psychiatric Hospital Idrija, Slovenia. Inpatients (N = 311) with schizophrenia spectrum disorders were observed. The causes for switching antipsychotics and switching strategies were analyzed. Analyzing a total of 3954 prescriptions, the collected data confirmed that treatment strategies in this psychiatric hospital are very complex. It was found that 37 percent of inpatients had at least one switch...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28229493/issues-with-monitoring-the-safety-of-psychoactive-products-under-a-legal-regulated-market-for-new-psychoactive-substances-legal-highs-in-new-zealand
#2
Marta Rychert, Chris Wilkins, Karen Witten
INTRODUCTION: New Zealand's Psychoactive Substances Act (2013) established the world's first regulated market for 'low risk' psychoactive products ('legal highs'). Under an interim PSA regime, 47 existing products were permitted to be continued to be sold. AIM: To explore issues with the implementation of regulatory systems to monitor the safety of products on the legal market under the interim Psychoactive Substances Act regime. METHODS: Semi-structured interviews with 30 key stakeholders, including industry, government agency, health and drug service professionals were conducted, transcribed and analysed thematically...
February 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#3
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226057/factors-that-interfere-with-the-response-of-nurses-in-the-monitoring-of-clinical-alarms
#4
Sónia Margarida Meireles Dinis, Isabel Cristina Mascarenhas Rabiais
Objective: The objective of the present study was to identify and synthesize the best empirical evidence found on factors that influence the response of nurses regarding clinical alarms. Method: An integrative literature review was conducted with searches undertaken in ten electronic databases restricted to the period from 2005 to 2016. Results: Eight articles were included by cross-checking the descriptors selected. Conclusion: In the analysis of the studies, the following possible factors that might interfere with the response of nurses in the monitoring of clinical alarms were found: high number of false alarms, inaudibility of alarms due to the competition of sounds, difficulty in distinguishing the urgency of alarms, and increase in noise caused by the raise in the number of alarms...
January 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28225655/mnte-2-pyp-treatment-or-nox4-inhibition-protects-against-radiation-induced-damage-in-mouse-primary-prostate-fibroblasts-by-inhibiting-the-tgf-beta-1-signaling-pathway
#5
Arpita Chatterjee, Elizabeth A Kosmacek, Rebecca E Oberley-Deegan
Prostate cancer patients who undergo radiotherapy frequently suffer from side effects caused by radiation-induced damage to normal tissues adjacent to the tumor. Exposure of these normal cells during radiation treatment can result in tissue fibrosis and cellular senescence, which ultimately leads to postirradiation-related chronic complications including urinary urgency and frequency, erectile dysfunction, urethral stricture and incontinence. Radiation-induced reactive oxygen species (ROS) have been reported as the most potent causative factor for radiation damage to normal tissue...
February 22, 2017: Radiation Research
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#6
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222271/pathways-to-lung-cancer-diagnosis-a-qualitative-study-of-patients-and-general-practitioners-about-diagnostic-and-pre-treatment-intervals
#7
Nicole M Rankin, Sarah York, Emily Stone, David Barnes, Deborah McGregor, Michelle Lai, Tim Shaw, Phyllis N Butow
RATIONALE: Pathways to lung cancer diagnosis and treatment are complex. International evidence shows significant variations in pathways. Qualitative research investigating pathways to lung cancer diagnosis rarely considers both patient and general practitioner views simultaneously. OBJECTIVES: To describe the lung cancer diagnostic pathway, focusing on the perspective of patients and general practitioners about diagnostic and pre-treatment intervals. METHODS: This qualitative study of lung cancer patients and general practitioners in Australia used qualitative interviews or a focus group in which participants responded to a semistructured questionnaire designed to explore experiences of the diagnostic pathway...
February 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28220609/the-long-term-predictive-value-of-preoperative-pressure-flow-studies-in-the-resolution-of-overactive-bladder-after-insertion-of-a-retropubic-midurethral-sling
#8
Jonathan Duckett, Aswini Balachandran
AIMS: To identify if the short term association of pressure flow rates with resolution of overactive bladder (OAB) is maintained in the long term in patients with mixed urodynamic incontinence treated with a retropubic midurethral sling. To assess if other demographic factors are associated with the long term resolution of OAB. METHODS: This was follow up study of a consecutive case series of 100 patients treated with a MUS at a single center followed up with questionnaires...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28220521/indirect-treatment-comparison-itc-of-medical-therapies-for-an-overactive-bladder
#9
Aneta Obloza, Joshua Kirby, Derrick Yates, Philip Toozs-Hobson
BACKGROUND: Overactive bladder syndrome (OAB) is a chronic and prevalent condition which has a negative impact on Quality of Life. The National Institute of Clinical Excellence issued two documents which give slightly varying algorithms of pharmacotherapy for OAB, offering mirabegron as a possible treatment in certain circumstances. In the absence of trials involving a direct comparison of therapies, an indirect comparison can provide useful information on the difference in treatment effects between competing interventions...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28219827/the-intervening-role-of-urgency-on-the-association-between-childhood-maltreatment-ptsd-and-substance-related-problems
#10
Rebecca Mirhashem, Holley C Allen, Zachary W Adams, Katherine van Stolk-Cooke, Alison Legrand, Matthew Price
A range of risk factors lead to opioid use and substance-related problems (SRP) including childhood maltreatment, elevated impulsivity, and psychopathology. These constructs are highly interrelated such that childhood maltreatment is associated with elevated impulsivity and trauma-related psychopathology such as posttraumatic stress disorder (PTSD), and impulsivity-particularly urgency-and PTSD are related. Prior work has examined the association between these constructs and substance-related problems independently and it is unclear how these multi-faceted constructs (i...
February 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28217699/the-female-urinary-microbiota-urinary-health-and-common-urinary-disorders
#11
REVIEW
Linda Brubaker, Alan J Wolfe
This review provides the clinical context and updated information regarding the female urinary microbiota (FUM), a resident microbial community within the female bladder of many adult women. Microbial communities have variability and distinct characteristics in health, as well as during community disruption (dysbiosis). Information concerning characteristics of the FUM in health and disease is emerging. Sufficient data confirms that the microbes that compose the FUM are not contaminants and are cultivatable under appropriate conditions...
January 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28217101/psychological-factors-and-alcohol-use-in-problematic-mobile-phone-use-in-the-spanish-population
#12
José De-Sola, Hernán Talledo, Gabriel Rubio, Fernando Rodríguez de Fonseca
This research aims to study the existing relationships among the factors of state anxiety, depression, impulsivity, and alcohol consumption regarding problematic mobile phone use, as assessed by the Mobile Phone Problem Use Scale. The study was conducted among 1,126 participants recruited among the general Spanish population, aged 16-65 years, by assessing the predictive value of these variables regarding this problematic use. Initially tobacco use was also considered being subsequently refused because of the low internal consistency of the scale used...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28214011/widespread-microplastic-ingestion-by-fish-assemblages-in-tropical-estuaries-subjected-to-anthropogenic-pressures
#13
A L Vendel, F Bessa, V E N Alves, A L A Amorim, J Patrício, A R T Palma
Our aim was to quantify microplastic ingestion by fish assemblages in two tropical Brazilian estuaries and to evaluate whether biological and ecological factors influence the ingestion of microplastics by fish species. Of 2233 fish from both estuaries (from 69 species) examined in this study, 9% of the individuals (24 species) had microplastics in their gut contents. Microplastic ingestion occurred irrespective of fish size and functional group. The diet of fish species was analyzed based on prey items identified in the fish's full stomach contents and five feeding guilds were defined...
February 14, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28213857/management-of-overactive-bladder-in-the-face-of-high-grade-prolapse
#14
REVIEW
Juan Guzman-Negron, Sandip Vasavada
Patients with pelvic organ prolapse (POP) may present with a large combination of symptoms including overactive bladder (OAB) symptoms such as urgency, frequency, and urgency incontinence. The explanation as to why these symptoms are more prevalent in POP patients is not clearly understood, but there seems to be an overall agreement that prolapse-induced bladder outlet obstruction (BOO) may trigger bladder changes resulting in OAB symptoms. Presuming this to be true, many of the studies managing OAB in POP patients have focused on the surgical management of prolapse and its aftermath, which in many of the patients leads to improvement of OAB symptoms...
February 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28213799/the-hybrid-technique-of-pelvic-organ-prolapse-treatment-apical-sling-and-subfascial-colporrhaphy
#15
Dmitry Shkarupa, Nikita Kubin, Alexey Pisarev, Anastasiya Zaytseva, Ekaterina Shapovalova
INTRODUCTION AND HYPOTHESIS: The majority of patients with cystocele undergoing reconstructive surgery have combined defects of pubocervical fascia and uterosacral/cardinal ligament complex. In this regard, the simultaneous correction of both defects is rational. Furthermore, decreasing the use of synthetic materials in pelvic floor surgery is an important goal. The aim was to evaluate the objective and subjective cure rate of a hybrid technique: bilateral sacrospinous fixation using modern monofilament synthetic tape (apical sling) combined with the original technique of subfascial colporrhaphy...
February 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28209157/stakeholder-perspectives-on-the-implementation-of-genetic-carrier-screening-in-a-changing-landscape
#16
Kim C A Holtkamp, Evelien M Vos, Tessel Rigter, Phillis Lakeman, Lidewij Henneman, Martina C Cornel
BACKGROUND: In most countries, genetic carrier screening is neither offered, nor embedded in mainstream healthcare. Technological developments have triggered a two-fold transition in carrier screening: the expansion from screening one single disorder to many disorders simultaneously, and offering screening universally, regardless of ancestry. This study aims to identify general and population-specific barriers and needs reflected by stakeholders regarding the implementation of carrier screening in a changing landscape...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28202356/bladder-capacity-is-a-biomarker-for-a-bladder-centric-versus-systemic-manifestation-in-interstitial-cystitis-bladder-pain-syndrome
#17
Stephen J Walker, Joao Zambon, Karl-Erik Andersson, Carl Langefeld, Catherine A Matthews, Gopal Badlani, Heather Bowman, Robert J Evans
PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) presents a significant clinical challenge due to symptom heterogeneity and the myriad associated comorbid medical conditions. We recently reported that diminished bladder capacity (BC) may represent a specific IC/BPS sub-phenotype. The objective of this study is to investigate the relationship between anesthetic bladder capacity and clinical findings (urologic and non-urologic) in a cohort of IC/BPS patients who had undergone therapeutic urinary bladder hydrodistention...
February 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28199874/biodegradation-of-polyethylene-microplastics-by-the-marine-fungus-zalerion-maritimum
#18
Ana Paço, Kátia Duarte, João P da Costa, Patrícia S M Santos, R Pereira, M E Pereira, Ana C Freitas, Armando C Duarte, Teresa A P Rocha-Santos
Plastic yearly production has surpassed the 300milliontons mark and recycling has all but failed in constituting a viable solution for the disposal of plastic waste. As these materials continue to accumulate in the environment, namely, in rivers and oceans, in the form of macro-, meso-, micro- and nanoplastics, it becomes of the utmost urgency to find new ways to curtail this environmental threat. Multiple efforts have been made to identify and isolate microorganisms capable of utilizing synthetic polymers and recent results point towards the viability of a solution for this problem based on the biodegradation of plastics resorting to selected microbial strains...
February 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28197002/an-exploratory-study-for-bladder-dysfunction-in-atypical-antipsychotic-emergent-urinary-incontinence
#19
Preeti Sinha, Anupam Gupta, V Senthil Kumar Reddi, Chittaranjan Andrade
INTRODUCTION: This is an exploratory study, which aimed to analyze urodynamic findings in patients who are on atypical antipsychotics and present with urinary incontinence (UI) in order to understand the mechanisms of antipsychotic-emergent UI. PATIENTS AND METHODS: Eight patients (34 ± 7.6 years; five males and three females) diagnosed with schizophrenia or other psychotic disorders, who were on risperidone, olanzapine, or clozapine monotherapy and having UI were recruited...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28194560/a-comparative-study-of-electroacupuncture-at-zhongliao-bl33-and-other-acupoints-for-overactive-bladder-symptoms
#20
Likun Yang, Yang Wang, Qian Mo, Zhishun Liu
Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detecting urodynamics in eight groups: no intervention group, D-BL33 group (deep needling at BL33), S-BL33 group (shallow needling at BL33), non-acupoint group (needling at the non-acupoint next to BL33), Weizhong (BL40) group, Sanyinjiao (SP6) group, Tongtian (BL7) group, and Hegu (LI4) group...
February 14, 2017: Frontiers of Medicine
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