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https://www.readbyqxmd.com/read/29037956/a-simple-and-cost-effective-assay-for-measuring-anti-drug-antibody-in-human-patients-treated-with-adalimumab
#1
Maohua Li, Hongzhen Li, Kai Gao, Muyang Wang, Wenqi An, Yaran Zhu, Li Ding, Lan Wang, Jingliang Gu, Conglin Zuo, Le Sun
It has been reported that 90% of the anti-drug antibody (ADA) to Adalimumab in human patients bound to the TNF-binding area, resulted in the annual loss of responses to Adalimumab up to 24%. It is of urgency to develop a cost-effective and easy-to-use ADA diagnostic kit for diagnosis of potential drug-resistance in patients treated with Adalimumab in clinic hospitals to avoid the tremendous economic and human costs to patients and health-care providers. In this study, we reported the generations of mouse monoclonal and monkey polyclonal antibodies against Adalimumab as assay standards and positive quality controls respectively...
October 13, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29034865/patients-attending-emergency-departments
#2
Martin Scherer, Dagmar Lühmann, Agata Kazek, Heike Hansen, Ingmar Schäfer
BACKGROUND: The number of patients in emergency departments has risen steadily in recent years, with a particular increase in patients not requiring urgent treatment. The aim of this study is to characterize this group of patients with respect to their sociodemographic features, health status, and reasons for attending an emergency department. METHODS: PiNo Nord is a cross-sectional observational study representing two full working weeks in five different hospitals...
September 29, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29034348/selection-of-patients-with-hepatocellular-cancer-a-difficult-balancing-between-equity-utility-and-benefit
#3
REVIEW
Alessandro Vitale, Quirino Lai
Although liver transplantation (LT) represents the gold-standard strategy for hepatocellular cancer (HCC), its use is circumscribed by several factors like donor shortage, perioperative complications, or competition with other candidates without HCC. Moreover, different alternative approaches like resection or loco-regional therapies may be attempted in selected cases. The best option for the treatment of an HCC patient is a complex decision, involving several ethical principles including: equity (horizontal equity and vertical equity or urgency), and utility...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29031894/refractory-urgency-urinary-incontinence-treatment-in-women-impact-of-age-on-outcomes-and-complications
#4
Yuko M Komesu, Cindy L Amundsen, Holly E Richter, Stephen W Erickson, Mary F Ackenbom, Uduak U Andy, Vivian W Sung, Michael Albo, W Thomas Gregory, Marie Fidela Paraiso, Dennis Wallace
BACKGROUND: Women with refractory urgency urinary incontinence (UUI) (i.e. unresponsive to behavioral and pharmacologic interventions) are treated with onabotulinumtoxinA or sacral neuromodulation. OBJECTIVES: To compare treatment efficacy and adverse events (AEs) in women <65 and ≥65 years old treated with onabotulinumtoxinA or sacral neuromodulation (SNM). STUDY DESIGN: This study was a planned secondary analysis of a multi-center, randomized trial which enrolled community-dwelling women with refractory UUI to onabotulinumtoxinA or SNM treatments...
October 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29031691/understanding-vaccine-hesitancy-in-polio-eradication-in-northern-nigeria
#5
Sebastian Taylor, Mahmud Khan, Ado Muhammad, Okey Akpala, Marit van Strien, Chris Morry, Warren Feek, Ellyn Ogden
BACKGROUND: Vaccine hesitancy constitutes a major threat to the Global Polio Eradication Initiative (GPEI), and to further expansion of routine immunisation. Understanding hesitancy, leading in some cases to refusal, is vital to the success of GPEI. Re-emergence of circulating wild poliovirus in northern Nigeria in mid-2016, after 24months polio-free, gives urgency to this. But it is equally important to protect and sustain the global gains available through routine immunisation in a time of rising scepticism and potential rejection of specific vaccines or immunisation more generally...
October 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29029959/ldt-classification-and-therapeutic-strategy-of-congenital-body-wall-defects
#6
Shun Wu, Ke Guo, Peng Xiao, Jiaming Sun
BACKGROUND: Repairing body wall defects is a critical step in the treatment of some congenital deformities, and this procedure may need the help from plastic surgeons. Although there are many articles about congenital deformities, body wall defects of these malformations are rarely studied as independent targets. METHODS: In this article, the authors present an LDT classification for congenital body wall defects according to the position of the defects, the tissue layers involved, and the surgical urgency, each of which is represented by letters L, D, and T, respectively...
September 19, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29028226/large-funding-inflows-limited-local-capacity-and-emerging-disease-control-priorities-a-situational-assessment-of-tuberculosis-control-in-myanmar
#7
Mishal S Khan, Sara Schwanke-Khilji, Joanne Yoong, Zaw Myo Tun, Samantha Watson, Richard James Coker
There are numerous challenges in planning and implementing effective disease control programmes in Myanmar, which is undergoing internal political and economic transformations whilst experiencing massive inflows of external funding. The objective of our study-involving key informant discussions, participant observations and linked literature reviews-was to analyse how tuberculosis (TB) control strategies in Myanmar are influenced by the broader political, economic, epidemiological and health systems context using the Systemic Rapid Assessment conceptual and analytical framework...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#8
REVIEW
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29026632/salmonella-oranienburg-haemorrhagic-cystitis-in-an-immunocompetent-young-male
#9
Jiasian Teh, Mark Quinlan, Damien Bolton
Introduction. Non-typhoidal salmonella (NTS) bacteriuria is extremely rare. Haemorrhagic cystitis is defined by urinary symptoms including haematuria, frequency, urgency and dysuria. Reports of haemorrhagic cystitis caused by NTS are exceptionally uncommon, especially in immunocompetent, young, male patients. Case presentation. A 27-year-old male with no past medical history presented to the Emergency Department with a 24 h history of visible haematuria having returned five days earlier from a five month trip across South America...
August 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026439/priority-setting-for-mental-health-research-in-chile
#10
Pedro Zitko, Francesca Borghero, Cynthia Zavala, Niina Markkula, Emilio Santelices, Nicolás Libuy, Alfredo Pemjean
BACKGROUND: Scientific knowledge is a fundamental tool for making informed health policy decisions, but the link between health research and public policy decision-making is often missing. This study aims to identify and prioritize a national set of research gaps in mental health. METHODS: A multi-approach method to identify gaps in knowledge was developed, including (1) document analysis and identification of possible research questions, (2) interviews to Ministry of Health key informants, (3) focus groups with different stakeholders, and (4) a web consultation addressed to academics...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29026056/patient-opinion-of-lower-urinary-tract-symptoms-and-their-treatment-a-cross-sectional-survey-in-hong-kong-public-urology-clinics
#11
L Y Ho, C K Chan, P Sk Chu
INTRODUCTION: Lower urinary tract symptoms collectively represent a common condition among ageing men. There are, however, limited data on the frequency of individual symptoms in patients who seek specialist care. We conducted a multinational survey in South-East Asia to evaluate patients' self-reported prevalence, bother, treatment, and treatment satisfaction of four lower urinary tract symptoms namely, urgency, nocturia, slow stream, and post-micturition dribble. This report presents the analysis of the Hong Kong subpopulation...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29025923/plasticity-of-signaling-by-spinal-estrogen-receptor-alpha-kappa-opioid-receptor-and-mglurs-over-the-rat-reproductive-cycle-regulates-spinal-endomorphin-2-antinociception-relevance-of-endogenous-biased-agonism
#12
Nai-Jiang Liu, Vijaya Murugaiyan, Emiliya M Storman, Stephen A Schnell, Arjun Kumar, Martin W Wessendorf, Alan R Gintzler
We previously showed that intrathecal application of endomorphin 2 [EM2; the highly specific endogenous mu-opioid receptor (MOR) ligand] induces antinociception that varies with stage of the rat estrous cycle -- minimal during diestrus and prominent during proestrus. Earlier studies, however, did not identify proestrus-activated signaling strategies that enable spinal EM2 antinociception. We now report that in female rats, increased spinal dynorphin release and kappa-opioid receptor (KOR) signaling, as well as the emergence of glutamate-activated mGluR1 signaling, are critical to the transition from an EM2 non-responsive (during diestrus) to an analgesically responsive state (during proestrus)...
October 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29025268/understanding-persuasive-attributes-of-sports-betting-advertisements-a-conjoint-analysis-of-selected-elements
#13
Nerilee Hing, Peter Vitartas, Matthew Lamont
Background and aims Despite recent growth in sports betting advertising, minimal research has examined the influence of different advertising message attributes on betting attitudes and behaviors. This study aimed to identify which attributes of sports betting advertisements most engage attention, interest, desire and likelihood of betting among non-problem, low-risk, moderate-risk, and problem gamblers. Methods A novel approach utilizing an experimental design incorporating conjoint analysis examined the effects of: three message formats (commentary, on-screen display, and studio crossover); four appeals (neutral, jovial, ease of placing the bet, and sense of urgency); three types of presenters (match presenter, sports betting operator, and attractive non-expert female presenter); and four bet types (traditional, exotic key event, risk-free, and micro-bet)...
October 13, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29024974/functional-recovery-in-major-depressive-disorder-providing-early-optimal-treatment-for-the-individual-patient
#14
Oloruntoba J Oluboka, Martin A Katzman, Jeffrey Habert, Diane McIntosh, Glenda M MacQueen, Roumen V Milev, Roger S McIntyre, Pierre Blier
Major depressive disorder (MDD) is an often chronic and recurring illness. Left untreated, MDD may result in progressive alterations in brain morphometry and circuit function. Recent findings, however, suggest that pharmacotherapy may halt and possibly reverse those effects. These findings, together with evidence that a delay in treatment is associated with poorer clinical outcomes, underscore the urgency of rapidly treating depression to full recovery. Early optimized treatment, using measurement-based care and customizing treatment to the individual patient, may afford the best possible outcomes for each patient...
September 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29024564/videourodynamic-factors-predictive-of-successful-onabotulinumtoxina-urethral-sphincter-injection-for-neurogenic-or-non-neurogenic-detrusor-underactivity
#15
Yuan-Hong Jiang, Jia-Fong Jhang, Sheng-Fu Chen, Hann-Chorng Kuo
OBJECTIVE: The aim of the present study was to analyze treatment outcomes and identify videourodynamic factors predictive of successful urethral onabotulinumtoxinA treatment of neurogenic and non-neurogenic detrusor underactivity (DU). METHODS: Patients with DU refractory to medical treatment were treated with injections totaling 100 U onabotulinumtoxinA into the urethral sphincter. Treatment outcomes were assessed 1 month after treatment using the Global Response Assessment...
October 11, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29020018/probabilistic-numerical-assessment-of-pyroclastic-current-hazard-at-campi-flegrei-and-naples-city-multi-vei-scenarios-as-a-tool-for-full-scale-risk-management
#16
Giuseppe Mastrolorenzo, Danilo M Palladino, Lucia Pappalardo, Sergio Rossano
The Campi Flegrei volcanic field (Italy) poses very high risk to the highly urbanized Neapolitan area. Eruptive history was dominated by explosive activity producing pyroclastic currents (hereon PCs; acronym for Pyroclastic Currents) ranging in scale from localized base surges to regional flows. Here we apply probabilistic numerical simulation approaches to produce PC hazard maps, based on a comprehensive spectrum of flow properties and vent locations. These maps are incorporated in a Geographic Information System (GIS) and provide all probable Volcanic Explosivity Index (VEI) scenarios from different source vents in the caldera, relevant for risk management planning...
2017: PloS One
https://www.readbyqxmd.com/read/29019749/pearls-and-pitfalls-in-diagnosing-pediatric-urinary-bladder-masses
#17
Susan C Shelmerdine, Armando J Lorenzo, Abha A Gupta, Govind B Chavhan
Urinary bladder masses are rare in children, and the associated histologic features and prognoses in this population are different from those in adults. Most children with urinary bladder masses present with lower urinary tract symptoms, which may include hematuria, dysuria, frequent urination, and urgency to urinate. However, some of these masses may be identified incidentally or involve generic symptoms such as abdominal distention. In general, pediatric bladder tumors can be divided into those that originate from the bladder epithelium, known as urothelial neoplasms, and mesenchymal bladder neoplasms, which are more prevalent...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29019544/pathophysiological-aspects-of-the-low-anterior-resection-syndrome-for-treatment-of-rectal-cancer
#18
Kelly Cristine de Lacerda Rodrigues Buzatti, Andy Petroianu
The number of patients with bowel dysfunction due to the treatment of rectal cancer has increased during the recent decades. Anatomical and functional disorders after the removal of the rectum are followed by increased stool frequency, urgency, multiple evacuations and flatus or stool incontinence characterizing the low anterior resection syndrome - LARS. The purpose of this article is to present a review of the literature on current concepts and pathophysiological aspects of bowel dysfunction after resection of rectal cancer...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29018995/impulsivity-and-response-latency-in-non-suicidal-self-injury-the-role-of-negative-urgency-in-emotion-regulation
#19
Brooke L Maxfield, Carolyn M Pepper
Impulsivity is thought to be a contributing factor in non-suicidal self-injury (NSSI), yet the research is limited and inconsistent. In particular, little is known about how impulsivity is associated with response latency between initial urge and later self-injury, emotion regulation processes, or severity of NSSI. In this study, we tested group differences between participants with and without a history of NSSI on a questionnaire measure of impulsivity. In addition, we tested hypothesized correlations between impulsivity and relevant variables within the NSSI sample using questionnaires and self-reported response latency between urge and injury...
October 11, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28994110/relapsing-polychondritis-an-underestimated-dermatological-urgency-case-report-and-literature-review
#20
Daniel Cuestas, Elkin Peñaranda, Sergio Mora, Carolina Cortes, Ingrid Galvis, Mónica Patiño, Oscar Velasquez
BACKGROUND: Relapsing polychondritis is an autoimmune multisystemic disease with primary chondral involvement. Its high mortality and morbidity make it a real clinical challenge. CASE DESCRIPTION: A 32-year-old woman with a history of relapsing polychondritis, refractory to multiple treatments, with multisystem compromise, imminent risk of death due to severe tracheobronchial damage and difficult ventilatory support, and successful treatment with infliximab. DISCUSSION AND EVALUATION: Several treatments have been described in the literature, such as nonsteroidal anti-inflammatory drugs, corticosteroids, dapsone, azathioprine, cyclosporine, cyclophosphamide, and methotrexate...
October 9, 2017: International Journal of Dermatology
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