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https://www.readbyqxmd.com/read/29220203/recent-advances-in-fertility-preservation-and-counseling-for-female-cancer-patients
#1
Marie-Madeleine Dolmans
Ensuring quality of life for increasing numbers of women surviving cancer has become a key challenge. Patients need to be counseled on potential fertility loss resulting from gonadotoxic treatments, and referred to fertility specialists to discuss existing options and available results. Areas covered: Fertility preservation options have existed for over twenty years. The proposed fertility preservation approach depends on patient age, the urgency of required chemotherapy, and psychosocial factors such as financial concerns, especially in countries where techniques are not covered by social security...
December 8, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29216932/nanobodies-targeting-conserved-epitopes-on-the-major-outer-membrane-protein-of-campylobacter-as-potential-tools-for-control-of-campylobacter-colonization
#2
Charlotte Vanmarsenille, Inés Díaz Del Olmo, Jelle Elseviers, Gholamreza Hassanzadeh Ghassabeh, Kristof Moonens, Didier Vertommen, An Martel, Freddy Haesebrouck, Frank Pasmans, Jean-Pierre Hernalsteens, Henri De Greve
Campylobacter infections are among the most prevalent foodborne infections in humans, resulting in a massive disease burden worldwide. Broilers have been identified as the major source of campylobacteriosis and reducing Campylobacter loads in the broiler caeca has been proposed as an effective measure to decrease the number of infections in humans. Failure of current methods to control Campylobacter in broilers stresses the urgency to develop novel mitigation measures. We obtained six nanobodies with a broad specificity, that recognize strains belonging to the two most relevant species, Campylobacter jejuni and Campylobacter coli...
December 8, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29216181/case-report-a-rare-case-of-urinary-myiasis-induced-by-the-fourth-instar-larvae-of-telmatoscopus-albipunctatus
#3
Beibei Zhang, Lifu Wang, Jiahua Liu, Lian Xu, Langui Song, Xiaoying Wu, Xi Sun, Zhongdao Wu
Telmatoscopus albipunctatus, a cosmopolitan fly, is widely distributed throughout moist environments. It is one of the most medically important insects (especially in urban environments) that may potentially cause myiasis. Urinary myiasis and other sites of infestation, including the intestine, nasal passages, lung, and derma, have been reported. This is the first case report of a Chinese middlescent woman infected with T. albipunctatus in Guangzhou, China. In the present report, a 50-year-old woman came to The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, because larvae were found when urinating in the morning; this had occurred every two days within the past two months...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29215517/two-year-results-of-burch-compared-with-midurethral-sling-with-sacrocolpopexy-a-randomized-controlled-trial
#4
Emanuel C Trabuco, Brian J Linder, Christopher J Klingele, Roberta E Blandon, John A Occhino, Amy L Weaver, Michaela E McGree, John B Gebhart
OBJECTIVE: To evaluate 1- and 2-year urinary continence rates after Burch retropubic urethropexy compared with a retropubic midurethral sling for women with urinary incontinence undergoing sacrocolpopexy. METHODS: We conducted a planned secondary analysis of a multicenter, randomized, single-blind trial comparing Burch with a sling that enrolled participants from June 2009 to August 2013. Objective outcome measures of continence were assessed at 1- and 2-year follow-up through office visits and validated questionnaires...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215421/educating-emergency-department-nurses-about-miscarriage
#5
Joyce L Merrigan
Miscarriage is the unwanted ending of a pregnancy before 20 weeks gestation. Women experiencing miscarriage require specialized care from nurses and other healthcare professionals. Many women are dissatisfied with emergency care related to miscarriage and desire honest communication, validation of urgency, and more robust information at discharge. Perinatal bereavement education offers an opportunity for emergency department nurses to acquire specific knowledge and communication skills that assist with understanding the individualized experience of early pregnancy loss...
January 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29213067/not-all-observed-actions-are-perceived-equally
#6
Artem Platonov, Guy A Orban
Action observation is the visual process analyzing the actions of others to determine their goals and how the actor's body (part) movements permit attaining those goals. Our recent psychophysical study demonstrated that 1) observed action (OA) perception differs from shape perception in viewpoint and duration dependence, and 2) accuracy and reaction times of OA discrimination are fitted by the proportional-rate diffusion model whereby a sensory stage provides noisy evidence that is accumulated up to a criterion or bound by a decision stage...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212863/modelling-the-implications-of-reducing-smoking-prevalence-the-benefits-of-increasing-the-uk-tobacco-duty-escalator-to-public-health-and-economic-outcomes
#7
Andre Knuchel-Takano, Daniel Hunt, Abbygail Jaccard, Arti Bhimjiyani, Martin Brown, Lise Retat, Katrina Brown, Sebastian Hinde, Chit Selvarajah, Linda Bauld, Laura Webber
INTRODUCTION: Taxing tobacco is one of the most effective ways to reduce smoking prevalence, mitigate its devastating consequential health harms and progress towards a tobacco-free society. This study modelled the health and economic impacts of increasing the existing cigarette tobacco duty escalator (TDE) in the UK from the current 2% above consumer price inflation to 5%. METHODS: A two-stage modelling process was used. First, a non-linear multivariate regression model was fitted to cross-sectional smoking data, creating longitudinal projections from 2015 to 2035...
December 6, 2017: Tobacco Control
https://www.readbyqxmd.com/read/29212457/the-decision-delivery-interval-in-emergency-caesarean-section-and-its-associated-maternal-and-fetal-outcomes-at-a-referral-hospital-in-northern-tanzania-a-cross-sectional-study
#8
Birjna A Hirani, Bariki L Mchome, Nicholaus S Mazuguni, Michael J Mahande
BACKGROUND: Decision delivery interval (DDI) is the time line between a decision to conduct an emergency caesarean section and actual delivery of the baby. Prolong DDI constitute a third phase delay in provision of emergency obstetric care. Intervention designed to minimize DDI are vital, in attempt to prevent maternal morbidity and neonatal morbidity and mortality. The feasibility and practicability of the recommended DDI in recent studies have been questioned especially in limited resource setting and therefore the objective of our study was to determine the DDI and its associated fetalmaternal outcomes at a tertiary referral hospital in Tanzania...
December 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29212087/knowledge-and-socio-demographic-determinants-of-emergency-management-of-dental-avulsion-among-parents-in-kuwait-a-cross-sectional-study
#9
Lolwa Alyahya, Sarah Alkandari, Saitah Alajmi, Asma Alyahya
<br>Objectives: To evaluate the parent's knowledge of first aid measures of a permanent tooth avulsion among parents in Kuwait and to assess the effect of different sociodemographic characteristics. <br> Materials (Subjects) and Methods<br>Materials and Methods: A cross-sectional study was conducted among 554 parents who visited five dental specialty centers in Kuwait. Participants' sociodemographic data and responses to avulsion management questions were collected through a self-administered questionnaire...
December 6, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29211399/oab-score-a-clinical-model-that-predicts-the-probability-of-presenting-overactive-detrusor-in-the-urodynamic-study
#10
Leandro Cristian Arribillaga, Marta Ledesma, Ariel Montedoro, Florencia Pisano, Rubén Guillermo Bengió
PURPOSE: To create a predictive model of involuntary detrusor contraction (IDC) to improve the diagnostic accuracy of overactive detrusor (OAD), associating overactive bladder (OAB) symptoms with other clinical parameters in the female population. MATERIALS AND METHODS: A total of 727 women were studied retrospectively. In all of them, urodynamic study was conducted for urogynecological causes. Demographics information, personal history, symptoms, physical exam, a 3-day frequency/volume chart and urinary culture, were collected in all patients and they subsequently underwent uroflowmetry and urodynamic studies...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29210475/a-rational-approach-to-metal-loading-of-organic-multi-site-polymers-illusion-or-reality
#11
Claude Piguet, Lucille Babel, Karine Baudet, Thi Nu Y Hoang, Homayoun Nozary
Since its identification as an independent topic after the first world war, the chemistry of (bio)polymers and macromolecules rapidly benefited from intense synthetic activities driven by contributors focussing on formulation and structural aspects. Satisfying rationalization and predictions concerning polymer organization, stability and reactivity were however delayed until the late fifties, when physical chemists set the basis of an adapted thermodynamic modelling. The recent emergence of metal-containing (bio)organic polymers (i...
December 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29206702/challenges-in-clarifying-goals-of-care-in-patients-with-advanced-heart-failure
#12
Patricia H Strachan, Jennifer Kryworuchko, Lin Li
PURPOSE OF REVIEW: Patients with advanced heart failure require communication about goals of care, yet many challenges exist, leaving it suboptimal. High mortality rates and advances in the use of life-sustaining technology further complicate communication and underscore the urgency to understand and address these challenges. This review highlights current research with a view to informing future research and practice to improve goals of care communication. RECENT FINDINGS: Clinicians view patient and family barriers as more impactful than clinician and system factors in impeding goals of care discussions...
November 27, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29205506/systematic-review-and-meta-analysis-on-the-efficacy-and-tolerability-of-mirabegron-for-the-treatment-of-storage-lower-urinary-tract-symptoms-overactive-bladder-comparison-with-placebo-and-tolterodine
#13
REVIEW
Arcangelo Sebastianelli, Giorgio I Russo, Steven A Kaplan, Kevin T McVary, Ignacio Moncada, Stavros Gravas, Christopher Chapple, Giuseppe Morgia, Sergio Serni, Mauro Gacci
A systematic review and meta-analysis was carried out to evaluate the efficacy and safety of mirabegron 50 mg and 100 mg in the treatment of storage lower urinary tract symptoms/overactive bladder in comparison with a placebo and tolterodine 4 mg. A total of 491 articles were collected and eight randomized studies were identified as eligible for this meta-analysis. Overall, eight trials were included in the meta-analysis evaluating 10 248 patients. Mirabegron at both doses of 50 mg and 100 mg, and and tolterodine 4 mg were significantly associated with the reduction of incontinence episodes per 24 h, reduction of mean number of micturitions per 24 h, increase of voided volume and reduction of urgency episodes per 24 h, compared to a placebo...
December 3, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29203368/modulating-autophagy-in-cancer-therapy-advancements-and-challenges-for-cancer-cell-death-sensitization
#14
REVIEW
Punya Bhat, Jurgen Kriel, Babu Shubha Priya, Basappa Salundi, Nanjunda Swamy Shivananju, Ben Loos
Autophagy is a major protein degradation pathway capable of upholding cellular metabolism under nutrient limiting conditions, making it a valuable resource to highly proliferating tumour cells. Although the regulatory machinery of the autophagic pathway has been well characterized, accurate modulation of this pathway remains complex in the context of clinical translatability for improved cancer therapies. In particular, the dynamic relationship between the rate of protein degradation through autophagy, i.e...
December 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29202940/genitourinary-syndrome-of-menopause-management-strategies-for-the-clinician
#15
REVIEW
Stephanie S Faubion, Richa Sood, Ekta Kapoor
Genitourinary syndrome of menopause (GSM), previously known as atrophic vaginitis or vulvovaginal atrophy, affects more than half of postmenopausal women. Caused by low estrogen levels after menopause, it results in bothersome symptoms, including vaginal dryness, itching, dyspareunia, urinary urgency and increased frequency, and urinary tract infections. Even though women with GSM can have sexual dysfunction that interferes with partner relationships, women are often embarrassed to seek treatment, and health care professionals do not always actively screen for GSM...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29202769/impact-of-systolic-blood-pressure-limits-on-the-diagnostic-value-of-triage-algorithms
#16
Tobias Neidel, Nicolas Salvador, Axel R Heller
BACKGROUND: Major incidents are characterized by a lack of resources compared to an overwhelming number of casualties, requiring a prioritization of medical treatment. Triage algorithms are an essential tool for prioritizing the urgency of treatment for patients, but the evidence to support one over another is very limited. We determined the influence of blood pressure limits on the diagnostic value of triage algorithms, considering if pulse should be palpated centrally or peripherally...
December 4, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29201417/cancer-survivors-of-gynecologic-malignancies-are-at-risk-for-decreased-opportunity-for-fertility-preservation
#17
Wael H Salem, Joe M Letourneau, Jessica Chan, Sai-Wing Chan, Marcelle Cedars, Mitchell P Rosen
Background: Cancer survivors rate fertility as one of the most important determinants of their quality of life in the years after cancer treatment. We seek to describe the reproductive goals of women affected by gynecologic cancers and investigate their specific challenges during fertility preservation (FP) counseling. Methods: Univariate & multivariate logistic regression were used for quantitative analysis of objective FP counseling measures between women with gynecologic (GYN) and non-gynecologic (non-GYN) cancers from a cross sectional survey...
2017: Contraception and Reproductive Medicine
https://www.readbyqxmd.com/read/29200467/examination-of-the-validity-and-reliability-of-the-french-version-of-the-brief-self-control-scale
#18
Damien Brevers, Jennifer Foucart, Paul Verbanck, Ofir Turel
This study aims to develop and to validate a French version of the Brief Self-Control Scale (BSCS; Tangney et al., 2004). This instrument is usually applied as a unidimensional self-report measure for assessing trait self-control, which captures one's dispositional ability to resist short-term temptation in order to reach more valuable long-term goals. Data were collected from two independent samples of French-speaking individuals (n1 = 287; n2 = 160). Results indicated that the French version of the BSCS can be treated as unidimensional, like the original questionnaire...
October 2017: Canadian Journal of Behavioural Science. Revue Canadienne des Sciences du Comportement
https://www.readbyqxmd.com/read/29199040/progress-towards-a-vaccine-against-ebola-to-meet-emergency-medical-countermeasure-needs
#19
Daniel N Wolfe, Amanda G Zarrabian, Gary L Disbrow, Eric M Espeland
The Ebola virus epidemic in West Africa proved to be the largest in the history of filovirus outbreaks, causing the World Health Organization to declare a public health emergency of international concern in August of 2014. In collaboration with domestic and international partners, the Biomedical Advanced Research and Development Authority (BARDA) initiated several vaccine development projects in support of the overall response efforts. The urgency associated with the epidemic triggered the clinical evaluation of lead vaccine candidates starting in late 2014...
November 30, 2017: Vaccine
https://www.readbyqxmd.com/read/29197314/improving-postoperative-efficiency-an-algorithm-for-expedited-void-trials-after-urogynecologic-surgery
#20
A Rebecca Meekins, Nazema Y Siddiqui, Cindy L Amundsen, Maragatha Kuchibhatla, Alexis A Dieter
OBJECTIVES: To evaluate the relation between voided volume and void trial "success" to create an algorithm that minimizes the need for postvoid residual volume (PVR) assessment in backfill-assisted void trials. METHODS: This article is an ancillary analysis of deidentified data from a randomized trial evaluating prophylactic antibiotics after urogynecologic surgery. Void trials were routinely performed after surgery; voided volumes, PVR, and void trial outcomes were collected...
December 2017: Southern Medical Journal
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