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https://www.readbyqxmd.com/read/27875032/management-of-renal-failure-in-end-stage-liver-disease-a-critical-appraisal
#1
REVIEW
Xingxing S Cheng, Jane C Tan, W Ray Kim
Renal failure is a late consequence of end-stage liver disease (ESLD). Even with liver transplantation, pretransplant renal impairment remains a strong predictor of posttransplant mortality. This review seeks to summarize and critically appraise common therapies used in this setting, including pharmacologic agents, procedures (transjugular intrahepatic portosystemic shunt, renal replacement therapy), and simultaneous liver-kidney transplantation. More experimental extracorporal modalities, eg, albumin dialysis or bioartificial livers, will not be discussed...
December 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27829060/comprehensive-comparison-of-multiple-detector-computed-tomography-and-dynamic-magnetic-resonance-imaging-in-the-diagnosis-of-hepatocellular-carcinoma-with-varying-degrees-of-fibrosis
#2
Ming-Tsung Lin, Chih-Chi Wang, Yu-Fan Cheng, Hock-Liew Eng, Yi-Hao Yen, Ming-Chao Tsai, Po-Lin Tseng, Kuo-Chin Chang, Cheng-Kun Wu, Tsung-Hui Hu
BACKGROUND & AIMS: Liver computed tomography and dynamic magnetic resonance imaging play an important role in the early detection of hepatocellular carcinoma. However, the American Association for the Study of Liver Diseases (AASLD) recommend the use of applied imaging studies for HCC diagnosis only in cirrhotic patients. This study aimed to comprehensively compare liver CT and dynamic MRI for HCC diagnosis before surgical resection over years in clinical practice, and also to compare the diagnostic differences between liver CT and dynamic MRI in HCCs with varying degrees of fibrosis...
2016: PloS One
https://www.readbyqxmd.com/read/27806815/new-direct-acting-antiviral-agents-for-the-treatment-of-hepatitis-c-2016-and-beyond
#3
Muhammad Umar, Tayyab Saeed Akhter
Hepatitis C is one of the commonest public health problems with 130 million people infected worldwide and the burden is increasing. Previously, Interferon along with Ribavirin was the mainstay of treatment but it was associated with toxic side effects. An all-oral regimen with higher rates of sustained viral response (SVR), minimal side effects and no restriction for liver fibrosis staging, was long awaited. Several all-oral interferon-free direct acting antiviral agents (DAAs) have now been approved by FDAfor different genotypes of HCV...
October 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27688661/development-of-a-prognostic-scoring-system-for-resectable-hepatocellular-carcinoma
#4
Carlo Sposito, Stefano Di Sandro, Federica Brunero, Vincenzo Buscemi, Carlo Battiston, Andrea Lauterio, Marco Bongini, Luciano De Carlis, Vincenzo Mazzaferro
AIM: To develop a prognostic scoring system for overall survival (OS) of patients undergoing liver resection (LR) for hepatocellular carcinoma (HCC). METHODS: Consecutive patients who underwent curative LR for HCC between 2000 and 2013 were identified. The series was randomly divided into a training and a validation set. A multivariable Cox model for OS was fitted to the training set. The beta coefficients derived from the Cox model were used to define a prognostic scoring system for OS...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27684824/diagnostic-performance-of-gadoxetic-acid-primovist-enhanced-mr-imaging-versus-ct-during-hepatic-arteriography-and-portography-for-small-hypervascular-hepatocellular-carcinoma
#5
Sun Young Yim, Beom Jin Park, Soon Ho Um, Na Yeon Han, Deuk Jae Sung, Sung Bum Cho, Seung Hwa Lee, Min Ju Kim, Jin Yong Jung, Jin Dong Kim, Yeon Seok Seo, Dong Sik Kim, Hyonggin An, Yun Hwan Kim
To compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with that of computed tomography (CT) during hepatic arteriography and arterial portography (CT HA/AP) for detecting hepatocellular carcinoma (HCC) from small hypervascular nodules.This retrospective study included 38 patients with 131 hypervascular nodules (≤2 cm) who had underwent MRI and CT HA/AP within a 2-week interval. Two observers analyzed MRI while other 2 observers analyzed CT HA/AP. Thereafter, MRI observers reviewed the CT HA/AP and magnetic resonance (MR) images again using both modalities...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27622200/treatment-response-after-radioembolisation-in-patients-with-hepatocellular-carcinoma-an-evaluation-with-dual-energy-computed-tomography
#6
Jens Altenbernd, Axel Wetter, Michael Forsting, Lale Umutlu
PURPOSE: The aim of this prospective study was to examine the diagnostic value of dual-energy CT (DECT) in the assessment of response of HCC after radioembolisation (RE). MATERIAL AND METHODS: 40 HCC patients with 82 measurable target lesions were included in this study. At baseline and follow-up examination target lesions were evaluated with (IU), AASLD and Choi measurement criteria. Disease control was defined as the sum of complete response (CR), partial response (PR), progression disease (PD) and stable disease (SD)...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27566593/hvpg-signature-a-prognostic-and-predictive-tool-in-hepatocellular-carcinoma
#7
Xiaolong Qi, Xin Zhang, Zhijia Li, Jialiang Hui, Yi Xiang, Jinjun Chen, Jianbo Zhao, Jing Li, Fu-Zhen Qi, Yong Xu
Hepatic venous pressure gradient (HVPG) measurement provides independent prognostic value in patients with cirrhosis, and the prognostic and predictive role of HVPG in hepatocellular carcinoma (HCC) also has been explored. The management of HCC is limited to the European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD) guidelines that consider that HVPG≥10 mmHg to be a contraindication for hepatic resection (HR), otherwise other treatment modalities are recommended...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27340355/genomic-change-in-hepatitis-b-virus-associated-with-development-of-hepatocellular-carcinoma
#8
Danbi Lee, Heather Lyu, Young-Hwa Chung, Jeong A Kim, Priya Mathews, Elizabeth Jaffee, Lei Zheng, Eunsil Yu, Young Joo Lee, Soo Hyung Ryu
AIM: To determine the genomic changes in hepatitis B virus (HBV) and evaluate their role in the development of hepatocellular carcinoma (HCC) in patients chronically infected with genotype C HBV. METHODS: Two hundred and forty chronic hepatitis B (CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter (BCP), and precore regions of HBV were sequenced using the direct sequencing method...
June 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27197711/cost-effectiveness-analysis-of-hepatocellular-carcinoma-screening-by-combinations-of-ultrasound-and-alpha-fetoprotein-among-alaska-native-people-1983-2012
#9
Prabhu P Gounder, Lisa R Bulkow, Martin I Meltzer, Michael G Bruce, Thomas W Hennessy, Mary Snowball, Philip R Spradling, Bishwa B Adhikari, Brian J McMahon
BACKGROUND: The American Association for the Study of Liver Diseases (AASLD) recommends semi-annual hepatocellular carcinoma (HCC) screening using ultrasound (US) in persons with chronic hepatitis B (CHB) virus infection at high risk for HCC such as Asian males aged ≥40 years and Asian females aged ≥50 years. OBJECTIVE: To analyse the cost-effectiveness of 2 HCC screening methods in the Alaska Native (AN) health system: US-alone, or screening by alpha-fetoprotein (AFP) initially and switching to US for subsequent screenings if AFP >10 ng/mL (AFP→US)...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27087015/systematic-review-current-concepts-and-challenges-for-the-direct-acting-antiviral-era-in-hepatitis-c-cirrhosis
#10
REVIEW
A Majumdar, M T Kitson, S K Roberts
BACKGROUND: The burden of HCV cirrhosis is high and projected to increase significantly over the next decade. While interferon therapy is problematic in HCV cirrhosis, the era of direct-acting anti-viral (DAA) therapy provides effective treatment for patients with cirrhosis. AIM: To systematically review the results of DAA therapy to date in patients with HCV cirrhosis, and highlight the ongoing challenges for DAA therapy in this population. METHODS: A structured Medline search was conducted to obtain phase II and III HCV trials in patients with cirrhosis...
June 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27070325/child-pugh-meld-and-albi-scores-for-predicting-the-in-hospital-mortality-in-cirrhotic-patients-with-acute-on-chronic-liver-failure
#11
Ying Peng, Xingshun Qi, Shanhong Tang, Han Deng, Jing Li, Zheng Ning, Junna Dai, Feifei Hou, Jiancheng Zhao, Ran Wang, Xiaozhong Guo
OBJECTIVES: Our study aimed to evaluate the discriminative abilities of Child-Pugh, model for end-stage liver disease (MELD), and albumin-bilirubin (ALBI) scores in predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure (ACLF). METHODS: Cirrhotic patients with ACLF admitted between 2010 January and 2014 June were retrospectively reviewed. Areas under the receiver operating characteristic curves (AUROCs) with 95% confidence intervals (CIs) were calculated...
August 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27055387/interventional-oncology-for-hepatocellular-carcinoma
#12
Julien Delicque, Mathieu Boulin, Boris Guiu, Jean-Pierre Pelage, Laure Escal, Valentina Schembri, Eric Assenat, Audrey Fohlen
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is increasing in incidence. The overall prognosis of patients with liver cancer is poor. The Barcelona Clinic Liver Cancer (BCLC) classification in 5 stages is endorsed by European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Disease (AASLD). This classification is recommended for treatment allocation. Because a small proportion of patients are suitable for curative surgical treatment, various locoregional therapies are widely used to manage patients with HCC...
April 4, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27014763/isolated-gastric-varices-and-use-of-balloon-occlusive-retrograde-transvenous-obliteration-a-case-report-and-literature-review
#13
Thomas R McCarty, Mena Bakhit, Tarun Rustagi
Isolated gastric varices are far less prevalent in Western countries where the rate of splenic thrombosis is much lower. However, in Asian countries the entity is more common and therefore a more robust treatment approach has been developed. Balloon-occlusive retrograde transvenous obliteration (BRTO) was first described in 1984 and then revived in 1996. The procedure, while uncommon in the U.S. and not recognized by the AASLD practice guidelines, allows for direct exclusion from the portosystemic system. Here we describe the case of a patient with alcoholic cirrhosis decompensated by bleeding gastric varices treated with BRTO...
March 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/26983394/-the-first-csh-aasld-dialogue-meeting-highlights-and-minutes
#14
R Huang, H Y Rao, H S Chen, L G Lu, L Wei
No abstract text is available yet for this article.
January 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/26967675/direct-acting-antiviral-treatment-in-adults-infected-with-hepatitis-c-virus-reactivation-of-hepatitis-b-virus-coinfection-as-a-further-challenge
#15
Anne De Monte, Johan Courjon, Rodolphe Anty, Eric Cua, Alissa Naqvi, Véronique Mondain, Jacqueline Cottalorda, Laurence Ollier, Valérie Giordanengo
Use of direct-acting antiviral drugs (DAAs) greatly improves management of adults infected with hepatitis C virus (HCV) whether patients are treatment-naive or unsuccessfully pre-treated. Several inhibitors of viral nonstructural proteins (NS3/4A protease, NS5A and NS5B polymerase) allow a rapid HCV clearance and increase rates of sustained virological response. Both the EASL and AASLD guidelines have recently published up-to-date recommendations for their use, addressing each HCV genotype and particular situations...
May 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/26940754/discontinuity-of-care-for-mothers-with-chronic-hepatitis-b-diagnosed-during-pregnancy
#16
R Rajbhandari, K Barton, A C Juncadella, A K Rubin, T Ajayi, Y Wu, A N Ananthakrishnan, R T Chung
Assiduous measures are taken to prevent perinatal transmission of hepatitis B virus (HBV) to infants; it is unclear whether the mothers receive appropriate care for their chronic HBV. We sought to assess the quality of HBV care in hepatitis B surface antigen (HBsAg)-positive mothers following pregnancy. HBsAg-positive women (n = 243) who had sought prenatal care at Massachusetts General Hospital were retrospectively identified and charts reviewed. The primary outcome was adherence to the American Association for the Study of Liver Diseases (AASLD) and American College of Obstetricians and Gynecologists guidelines...
July 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/26902945/clinical-trial-watch-reports-from-the-liver-meeting%C3%A2-aasld-san-francisco-november-2015
#17
REVIEW
Johannes Wiegand, Florian van Bömmel, Andrés Duarte-Rojo, José Altamirano, Juan G Abraldes, Augusto Villanueva, Thomas Berg
No abstract text is available yet for this article.
June 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/26840452/disparate-access-to-treatment-regimens-in-chronic-hepatitis-c-patients-data-from-the-trio-network
#18
Z M Younossi, B R Bacon, D T Dieterich, S L Flamm, K Kowdley, S Milligan, N Tsai, A Nezam
Despite the clinical success in the real-world of all oral hepatitis C virus (HCV) therapy with response rates approaching that seen in the clinical trials, access has been limited by many payers with discussion of prioritization of treatment based upon AASLD guidelines. We evaluated patients in the TRIO network who were prescribed sofosbuvir (SOF)-based regimens to determine reasons for not starting treatment. Trio Health is a disease management company that works in partnership with academic medical centres, community physicians and specialty pharmacies in the United States to optimize care for HCV...
June 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/26821497/-resistance-of-hcv-to-new-direct-acting-antivirals
#19
Yael Gozlan, Ella Mendelson, Ziv Ben-Ari, Orna Mor
Hepatitis C virus (HCV) is a leading cause of chronic viral hepatitis affecting 130-150 million people world-wide. HCV is an RNA virus of the Flaviviridae family, containing ~9600 nucleic acids coding for structural and nonstructural proteins, divided into 7 genotypes of which the most prevalent is genotype 1. The goal of HCV therapy is to achieve sustained virological response (SVR), currently defined as undetectable serum HCV RNA 12 weeks post-treatment. Treatment with the new direct acting antivirals (DAAs) that target the HCV protease NS3/4A, NS5A and the NS5B polymerase proteins can lead to more than 90% SVR...
November 2015: Harefuah
https://www.readbyqxmd.com/read/26780632/management-of-difficult-cases-of-autoimmune-hepatitis
#20
REVIEW
Craig Lammert, Veronica M Loy, Kiyoko Oshima, Samer Gawrieh
Autoimmune hepatitis (AIH) is a complex autoimmune disease characterized by immune-mediated destruction of hepatic parenchyma which can result in cirrhosis, liver failure, and death. Current American Association for the Study of Liver Diseases (AASLD) and European Association for the Study of Liver (EASL) guidelines recommend corticosteroids alone or in combination with azathioprine as first-line treatment strategies. However, a significant proportion of patients may not be able to tolerate or achieve complete biochemical response with these options...
February 2016: Current Gastroenterology Reports
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