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https://www.readbyqxmd.com/read/27902293/colwellia-marinimaniae-sp-nov-a-hyperpiezophilic-species-isolated-from-an-amphipod-within-the-challenger-deep-mariana-trench
#1
Masataka Kusube, Than S Kyaw, Kumiko Tanikawa, Roger A Chastain, Kevin Hardy, James Cameron, Douglas H Bartlett
An obligately piezophilic strain was isolated from an amphipod crustacean obtained in the Challenger Deep region of the Mariana Trench during the DEEPSEA CHALLENGE expedition. The strain, MTCD1T, grew at extremely high hydrostatic pressures, with a growth range of 80-140 MPa (optimum: 120 MPa) at 6°C. Phylogenetic analyses based on the 16S rRNA gene sequence indicates that it is closely affiliated with the genus Colwellia. Comparative 16S rRNA gene sequence analyses revealed 95.7%, 95.5%, and 95.2% similarity to Colwellia maris ABE-1T, Colwellia piezophila Y233GT, and Colwellia psychrerythraea 34HT, respectively...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902285/raineyella-antarctica-gen-nov-sp-nov-a-novel-psychrotolerant-d-amino-acid-utilizing-anaerobe-isolated-from-two-geographic-locations-of-the-southern-hemisphere
#2
Elena V Pikuta, Rodolfo Javier Menes, Alisa Michelle Bruce, Zhe Lyu, Nisha Patel, Yuchen Liu, Richard Brice Hoover, Hans Jürgen Busse, Paul A Lawson, William Barney Whitman
Gram-positive bacterium, strain LZ-22T, was isolated from a rhizosphere of moss Leptobryum sp. collected at the shore of Lake Zub in Antarctica. Cells were motile, straight or pleomorphic rods with sizes of 0.6-1.0 x 3.5-10 μm. The new isolate was a facultatively anaerobic, catalase positive, psychrotolerant mesophile. Growth was observed at 3-41 oC (optimum 24-30 oC), 0-7 % NaCl, w/v (optimum, 0.25 %) and pH 4.0-9.0 (optimum 7.8). The quinone system of strain LZ-22T possessed predominately menaquinones MK-9(H4)...
October 12, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902243/rugosibacter-aromaticivorans-gen-nov-sp-nov-a-novel-bacterium-within-the-family-rhodocyclaceae-isolated-from-contaminated-soil-capable-of-degrading-aromatic-compounds
#3
Elizabeth M Corteselli, Michael D Aitken, David R Singleton
A bacterial strain designated Ca6T was isolated from polycyclic aromatic hydrocarbon (PAH)-contaminated soil from the site of a former manufactured gas plant in Charlotte, North Carolina, USA and phylogenetically linked to the Rhodocyclaceae family of the Betaproteobacteria. Its 16S rRNA gene was highly similar to globally distributed environmental sequences, including those previously designated "Pyrene Group 1" demonstrated to grow on the PAHs phenanthrene and pyrene by stable-isotope probing. The closest described relative was Sulfuritalea hydrogenivorans strain sk43HT (93...
October 27, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900318/templated-sequence-insertion-polymorphisms-in-the-human-genome
#4
REVIEW
Masahiro Onozawa, Peter D Aplan
Templated Sequence Insertion Polymorphism (TSIP) is a recently described form of polymorphism recognized in the human genome, in which a sequence that is templated from a distant genomic region is inserted into the genome, seemingly at random. TSIPs can be grouped into two classes based on nucleotide sequence features at the insertion junctions; Class 1 TSIPs show features of insertions that are mediated via the LINE-1 ORF2 protein, including (1) target-site duplication (TSD), (2) polyadenylation 10-30 nucleotides downstream of a "cryptic" polyadenylation signal, and (3) preference for insertion at a 5'-TTTT/A-3' sequence...
2016: Frontiers in Chemistry
https://www.readbyqxmd.com/read/27897994/disability-physical-inactivity-and-impaired-health-related-quality-of-life-are-not-different-in-metabolically-healthy-vs-unhealthy-obese-subjects
#5
Lorenzo M Donini, Gianluca Merola, Eleonora Poggiogalle, Carla Lubrano, Lucio Gnessi, Stefania Mariani, Silvia Migliaccio, Andrea Lenzi
BACKGROUND: Obesity represents a major health hazard, affecting morbidity, psychological status, physical functionality, quality of life, and mortality. The aim of the present study was to explore the differences between metabolically healthy (MHO) and metabolically unhealthy (MUO) obese subjects with regard to physical activity, disability, and health-related quality of life (HR-QoL). METHODS: All subjects underwent a multidimensional evaluation, encompassing the assessment of body composition, metabolic biomarkers and inflammation, physical activity level (IPAQ questionnaire), disability (TSD-OC test), and HR-QoL (SF-36 questionnaire)...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27879213/generation-of-hexa-deficient-hipscs-from-fibroblasts-of-a-tay-sachs-disease-patient
#6
Zhong Liu, Rui Zhao
Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD). The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers...
September 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27874293/improved-stability-of-solid-dispersions-of-manidipine-with-polyethylene-glycol-4000-copovidone-blends-application-of-ternary-phase-diagram
#7
Benchawan Chamsai, Sontaya Limmatvapirat, Srisagul Sungthongjeen, Pornsak Sriamornsak
CONTEXT: Manidipine (MDP) is generally used clinically as an antihypertensive agent; however, the bioavailability of orally administered MDP is limited very low due to their very low water solubility. OBJECTIVE: The objectives of this research were, therefore, to increase the solubility of MDP by the formation of ternary solid dispersions (tSD) with polyethylene glycol 4000 (PEG4000) and copovidone and to improve their stability. METHODS: Solid ternary phase diagram was constructed to find homogeneous solid dispersion region after melting and solidifying at low temperature with different quenching substances...
November 22, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27867438/total-sleep-deprivation-and-pain-perception-during-cold-noxious-stimuli-in-humans
#8
Robert A Larson, Jason R Carter
BACKGROUND AND AIMS: A substantial portion of the population suffers from chronic pain leading to significant health care costs and lost productivity. Loss of sleep duration and quality are widely reported in patients suffering from a variety of acute or chronic pain conditions. Conversely, sleep loss has been known to elevate pain perception; thus a potential bi-directional relationship exists between sleep deprivation and pain. To date, the majority of studies examining the relationship between experimentally induced pain and sleep loss have focused on the measurement of pain threshold...
October 2016: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/27832308/mechanism-of-electron-transport-during-thiosulfate-oxidation-in-an-obligately-mixotrophic-bacterium-thiomonas-bhubaneswarensis-strain-s10-dsm-18181-t
#9
Kunwar Digvijay Narayan, Surendra Chandra Sabat, Subrata K Das
This study describes the thiosulfate-supported respiratory electron transport activity of Thiomonas bhubaneswarensis strain S10 (DSM 18181(T)). Whole-genome sequence analysis revealed the presence of complete sox (sulfur oxidation) gene cluster (soxCDYZAXB) including the sulfur oxygenase reductase (SOR), sulfide quinone reductase (SQR), sulfide dehydrogenase (flavocytochrome c (fcc)), thiosulfate dehydrogenase (Tsd), sulfite dehydrogenase (SorAB), and intracellular sulfur oxidation protein (DsrE/DsrF). In addition, genes encoding respiratory electron transport chain components viz...
November 10, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27826994/diagnostic-efficacy-of-single-pass-abdominal-multidetector-row-ct-prospective-evaluation-of-a-low-dose-protocol
#10
Luigi Camera, Immacolata Liccardo, Federica Romano, Raffaele Liuzzi, Antonio Rispo, Massimo Imbriaco, Anna Testa, Gaetano Luglio, Simona De Fronzo, Fabiana Castiglione, Luigi Bucci, Arturo Brunetti
OBJECTIVES: To evaluate the diagnostic efficacy of single-pass contrast-enhanced multi-detector CT (CE-MDCT) performed with a low radiation-high contrast (LR-HC) dose protocol in selected patients with non traumatic acute bowel disease. METHODS: Sixty-five (32 M; 33 F; aged 20-67 years) consecutive patients with non traumatic acute bowel disease underwent single-pass CE-MDCT performed 70-100 sec after i.v. bolus injection of a non ionic iodinated contrast media (370 mgI/ml)...
November 9, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27798296/thyroid-hormone-modulates-offspring-sex-ratio-in-a-turtle-with-temperature-dependent-sex-determination
#11
Bao-Jun Sun, Teng Li, Yi Mu, Jessica K McGlashan, Arthur Georges, Richard Shine, Wei-Guo Du
The adaptive significance of temperature-dependent sex determination (TSD) has attracted a great deal of research, but the underlying mechanisms by which temperature determines the sex of a developing embryo remain poorly understood. Here, we manipulated the level of a thyroid hormone (TH), triiodothyronine (T3), during embryonic development (by adding excess T3 to the eggs of the red-eared slider turtle Trachemys scripta, a reptile with TSD), to test two competing hypotheses on the proximate basis for TSD: the developmental rate hypothesis versus the hormone hypothesis Exogenous TH accelerated embryonic heart rate (and hence metabolic rate), developmental rate, and rates of early post-hatching growth...
October 26, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27792652/incremental-value-of-speckle-tracking-echocardiography-to-predict-cardiac-resynchronization-therapy-crt-responders
#12
Yoshihiro Seo, Tomoko Ishizu, Tomoko Machino-Ohtsuka, Masayoshi Yamamoto, Takeshi Machino, Kenji Kuroki, Hiro Yamasaki, Yukio Sekiguchi, Akihiko Nogami, Kazutaka Aonuma
BACKGROUND: Speckle tracking echocardiography (STE) is reported as a useful method to predict cardiac resynchronization therapy (CRT) responders. This study aimed to identify the incremental value of a STE parameter to predict CRT responders. METHODS AND RESULTS: We enrolled 171 patients from the Speckle Tracking imaging for the Assessment of cardiac Resynchronization Therapy (START) study. CRT responders were defined as patients with ≥15% reduction of left ventricular (LV) end-systolic volume at 6 months post-CRT...
October 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27782172/procedural-performance-following-sleep-deprivation-remains-impaired-despite-extended-practice-and-an-afternoon-nap
#13
Irma Triasih Kurniawan, James Nicholas Cousins, Pearlynne L H Chong, Michael W L Chee
The negative impact of sleep loss on procedural memory is well established, yet it remains unclear how extended practice opportunities or daytime naps can modulate the effect of a night of sleep deprivation. Here, participants underwent three training and test conditions on a sequential finger tapping task (SFTT) separated by at least one week. In the first condition they were trained in the evening followed by a night of sleep. Two further conditions took place where evening training was followed by a night of total sleep deprivation (TSD)...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27764929/-mortality-from-respiratory-diseases-in-the-provinces-of-apulia-region-southern-italy-from-1933-to-2010
#14
Maria Rosa Montinari, Emilio Antonio Luca Gianicolo, Maria Angela Vigotti
OBIETTIVI: valutare l'andamento temporale della mortalità per patologie respiratorie nelle province pugliesi utilizzando dati omogenei per fonte e metodologia di calcolo. DISEGNO: analisi ecologica storica degli andamenti temporali di mortalità per tumori e patologie dell'apparato respiratorio nelle province pugliesi, in Puglia e nelle ripartizioni geografiche italiane dal 1933 al 2010. SETTING E PARTECIPANTI: i dati di mortalità e le popolazioni residenti sono di fonte Istat. Sono state esaminate tutte le cause di decesso, il tumore della laringe, il tumore del polmone, l'insieme dei tumori respiratori, la bronchite, la polmonite e la broncopolmonite considerate congiuntamente, e l'insieme delle patologie respiratorie...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27764925/-ecological-study-on-the-mortality-of-residents-in-manfredonia-apulia-region-southern-italy-from-1970-to-2013
#15
Emilio Antonio Luca Gianicolo, Cristina Mangia, Marco Cervino, Antonella Bruni, Bruna De Marchi, Annibale Biggeri, Rosa Porcu, Maria Angela Vigotti
OBIETTIVI: valutare lo stato di salute della popolazione residente nel comune di Manfredonia dal 1970 al 2013. DISEGNO: analisi descrittiva dell'andamento temporale della mortalità generale, per gruppi di cause, dal 1970 al 2013. SETTING E PARTECIPANTI: i dati di mortalità e le popolazioni residenti sono di fonte Istat. Sono state esaminate 55 cause di decesso. Le analisi sono disaggregate per sesso e periodo. PRINCIPALI MISURE DI OUTCOME: sono stati elaborati i rapporti standardizzati di mortalità (SMR%), con i rispettivi intervalli di confidenza al 90% (IC90%), e i tassi di mortalità standardizzati col metodo diretto (TSD )...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27754237/os-34-04-safety-of-early-intensive-blood-pressure-lowering-in-cerebral-small-vessel-disease-and-chronic-kidney-disease-in-acute-intracerebral-hemorrhage
#16
Craig Anderson, Shoichiro Sato, Candice Delcourt, Hisatomi Arima, Shihong Zhang, Rustam RAl-Shahi Salman, Christian Stapf, Dan Woo, Matthew Flaherty, Achala Vagal, Jiguang Wang, John Chalmers
OBJECTIVE: The INTERACT2 trial demonstrated beneficial effects of early intensive blood pressure (BP) lowering in intracerebral hemorrhage (ICH). However, concerns persist over harms associated with the treatment, particularly in patients with cerebral small vessel disease (CSVD) (ie white matter lesions [WML], lacunes and atrophy) and renal failure. We determined associations of CSVD, and renal failure, on outcomes in INTERACT2 participants. DESIGN AND METHOD: There were 2069/2839 patients with baseline brain CT (< 6hr ICH onset)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27744116/differential-effects-of-total-and-partial-sleep-deprivation-on-salivary-factors-in-wistar-rats
#17
Dr T J Lasisi, S T Shittu, C C Meludu, A A Salami
OBJECTIVE: Aim of this study was to investigate the effects of sleep deprivation on salivary factors in rats. DESIGN: Animals were randomly assigned into three groups of 6 animals each as control, total sleep deprivation (TSD) and partial sleep deprivation (PSD) groups. The multiple platform method was used to induce partial and total sleep deprivation for 7days. On the 8th day, stimulated saliva samples were collected for the analysis of salivary lag time, flow rate, salivary amylase activity, immunoglobulin A secretion rate and corticosterone levels using ELISA and standard kinetic enzyme assay...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27682588/tay-sachs-disease-mutations-in-hexa-target-the-%C3%AE-chain-of-hexosaminidase-a-to-endoplasmic-reticulum-associated-degradation
#18
Devin Dersh, Yuichiro Iwamoto, Yair Argon
Loss of function of the enzyme β-hexosaminidase A (HexA) causes the lysosomal storage disorder Tay-Sachs disease (TSD). It has been proposed that mutations in the α chain of HexA can impair folding, enzyme assembly, and/or trafficking, yet there is surprisingly little known about the mechanisms of these potential routes of pathogenesis. We therefore investigated the biosynthesis and trafficking of TSD-associated HexA α mutants, seeking to identify relevant cellular quality control mechanisms. The α mutants E482K and G269S are defective in enzymatic activity, unprocessed by lysosomal proteases, and exhibit altered folding pathways compared with wild-type α...
December 1, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27676975/objective-measure-of-bradykinesia-in-parkinsonism-by-the-maximal-frequency-of-standardized-large-pronation-supination-movements
#19
Jean-Michel Gracies, Caroline Radot, Marieke Chamberon
OBJECTIVE: Bradykinesia in Parkinson's disease (PD) predominates in large movements. Traditional assessments use the UPDRS, a subjective and ordinal tool that does not rate movement scaling (hypometria). We have measured the maximum frequency of standardized large alternating elbow pronation/supination movements in patients with PD, hypothesizing a negative correlation with the UPDRS III score and with the delay since diagnosis. MATERIALS/PATIENTS AND METHODS: We carried out a retrospective study on a convenience sample of 30 patients with idiopathic PD from Henri Mondor University Hospitals (Créteil, France), all assessed in the clinically defined OFF state by a single rater...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27671871/a-timecourse-analysis-of-systemic-and-gonadal-effects-of-temperature-on-sexual-development-of-the-red-eared-slider-turtle-trachemys-scripta-elegans
#20
Michael Czerwinski, Anirudh Natarajan, Lindsey Barske, Loren L Looger, Blanche Capel
Temperature dependent sex determination (TSD) is the process by which the environmental temperature experienced during embryogenesis influences the sex of an organism, as in the red-eared slider turtle Trachemys scripta elegans. In accord with current paradigms of vertebrate sex determination, temperature is believed to exert its effects on sexual development in T. scripta entirely within the middle third of development, when the gonad is forming. However, whether temperature regulates the transcriptome in T...
December 1, 2016: Developmental Biology
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