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unstable angina pectoris and non st elevation myocardial infarction

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https://www.readbyqxmd.com/read/28902641/assessment-of-the-association-between-the-personality-traits-of-young-patients-with-acute-coronary-syndrome-and-the-severity-of-coronary-artery-disease
#1
Nermin Bayar, Ramazan Güven, Zehra Erkal, Kamil Can Akyol, Mustafa Ilker Edebali, Selçuk Küçükseymen, Şakir Arslan
OBJECTIVE: The role of psychosocial risk factors is becoming increasingly important in the etiology of acute coronary syndrome (ACS). The purpose of this study was to assess an association between the personality types of young patients with ACS and the prevalence and severity of coronary artery disease (CAD). METHODS: Patients younger than 45 years of age who presented with ACS and who underwent coronary angiography in the period from 2012 to 2016 were included in the study...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28832903/drug-eluting-stents-versus-bare-metal-stents-for-acute-coronary-syndrome
#2
REVIEW
Joshua Feinberg, Emil Eik Nielsen, Janette Greenhalgh, Juliet Hounsome, Naqash J Sethi, Sanam Safi, Christian Gluud, Janus C Jakobsen
BACKGROUND: Approximately 3.7 million people died from acute coronary syndrome worldwide in 2012. Acute coronary syndrome, also known as myocardial infarction or unstable angina pectoris, is caused by a sudden blockage of the blood supplied to the heart muscle. Percutaneous coronary intervention is often used for acute coronary syndrome, but previous systematic reviews on the effects of drug-eluting stents compared with bare-metal stents have shown conflicting results with regard to myocardial infarction; have not fully taken account of the risk of random and systematic errors; and have not included all relevant randomised clinical trials...
August 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28435280/high-adherence-to-therapy-and-low-cardiac-mortality-and-morbidity-in-patients-after-acute-coronary-syndrome-systematically-managed-by-office-based-cardiologists-in-germany-1-year-outcomes-of-the-proacor-study
#3
Franz Goss, Johannes Brachmann, Christian W Hamm, Winfried Haerer, Nicolaus Reifart, Benny Levenson
We aimed to assess patient acceptance and effectiveness of a 12-month structured management program in patients after an acute coronary syndrome (ACS) event who were treated in a special setting of office-based cardiologists. The program comprised patient documentation with a specific tool (Bundesverband Niedergelassener Kardiologen [German Federation of Office-Based Cardiologists] cardiac pass with visit scheduling) shared by the hospital physician and the office-based cardiologist, the definition of individual treatment targets, and the systematic information of patients in order to optimize adherence to therapy...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28237549/il-37-increased-in-patients-with-acute-coronary-syndrome-and-associated-with-a-worse-clinical-outcome-after-st-segment-elevation-acute-myocardial-infarction
#4
Kun Liu, Qiang Tang, Xinyuan Zhu, Xinchun Yang
BACKGROUND: IL-37 emerges as a natural suppressor of inflammatory responses. The potential role of IL-37 in the pathology of atherosclerosis is unclear. The purpose of this study was to assess IL-37 profile in acute coronary syndrome (ACS) and the prognostic role of this cytokine in patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). METHODS: In a case-control study, we prospectively enrolled 216 patients undergoing the first coronary angiography, which consisted of 5 groups: normal (n=57), stable angina (SAP, n=36), unstable angina (UAP, n=42), non-STEMI (n=36), STEMI (n=45)...
February 24, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28092977/hypertension-is-associated-with-increased-mortality-in-patients-with-ischaemic-heart-disease-after-revascularization-with-percutaneous-coronary-intervention-a-report-from-scaar
#5
Ott Saluveer, Björn Redfors, Oskar Angerås, Christian Dworeck, Inger Haraldsson, Charlotta Ljungman, Petur Petursson, Jacob Odenstedt, Dan Ioanes, Peter Lundgren, Sebastian Völz, Truls Råmunddal, Bert Andersson, Elmir Omerovic, Niklas Bergh
BACKGROUND: The prognostic role of hypertension on long-term survival after percutaneous coronary intervention (PCI) is limited and inconsistent. We hypothesize that hypertension increases long-term mortality after PCI. METHODS: We analyzed data from SCAAR (Swedish Coronary Angiography and Angioplasty Registry) for all consecutive patients admitted coronary care units in Sweden between January 1995 and May 2013 and who underwent PCI due to ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI)/unstable angina (UA) or stable angina pectoris...
June 2017: Blood Pressure
https://www.readbyqxmd.com/read/27981367/-cardiac-causes-of-chest-pain
#6
REVIEW
C Wächter, B Markus, B Schieffer
Because of the life-threatening character and a high prevalence in emergency rooms, cardiac causes are important differential diagnoses of acute chest pain with the need for rapid clarification. In this context the working diagnosis "acute coronary syndrome" (ACS) plays a major role. In a synopsis of the clinical presentation, medical history, electrocardiogram and analysis of cardiac biomarkers, ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina pectoris can be specified as entities of ACS...
January 2017: Der Internist
https://www.readbyqxmd.com/read/27816119/gender-differences-in-outcomes-and-predictors-of-all-cause-mortality-after-percutaneous-coronary-intervention-data-from-united-kingdom-and-sweden
#7
Vijay Kunadian, Weiliang Qiu, Bo Lagerqvist, Nina Johnston, Hannah Sinclair, Ying Tan, Peter Ludman, Stefan James, Giovanna Sarno
To determine gender differences and predictors of all-cause mortality (30 days and 1 year) after percutaneous coronary intervention (PCI) in patients with stable angina pectoris and acute coronary syndrome (non-ST-elevation myocardial infarction/unstable angina pectoris and ST-elevation myocardial infarction) in the British Cardiovascular Intervention Society (BCIS) and Swedish Coronary Angiography and Angioplasty Registry (SCAAR) data sets, an analysis of prospectively collected data from 2007 to 2011 was performed...
January 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27810312/percutaneous-coronary-angioplasty-versus-coronary-artery-bypass-grafting-in-treatment-of-unprotected-left-main-stenosis-noble-a-prospective-randomised-open-label-non-inferiority-trial
#8
RANDOMIZED CONTROLLED TRIAL
Timo Mäkikallio, Niels R Holm, Mitchell Lindsay, Mark S Spence, Andrejs Erglis, Ian B A Menown, Thor Trovik, Markku Eskola, Hannu Romppanen, Thomas Kellerth, Jan Ravkilde, Lisette O Jensen, Gintaras Kalinauskas, Rikard B A Linder, Markku Pentikainen, Anders Hervold, Adrian Banning, Azfar Zaman, Jamen Cotton, Erlend Eriksen, Sulev Margus, Henrik T Sørensen, Per H Nielsen, Matti Niemelä, Kari Kervinen, Jens F Lassen, Michael Maeng, Keith Oldroyd, Geoff Berg, Simon J Walsh, Colm G Hanratty, Indulis Kumsars, Peteris Stradins, Terje K Steigen, Ole Fröbert, Alastair N J Graham, Petter C Endresen, Matthias Corbascio, Olli Kajander, Uday Trivedi, Juha Hartikainen, Vesa Anttila, David Hildick-Smith, Leif Thuesen, Evald H Christiansen
BACKGROUND: Coronary artery bypass grafting (CABG) is the standard treatment for revascularisation in patients with left main coronary artery disease, but use of percutaneous coronary intervention (PCI) for this indication is increasing. We aimed to compare PCI and CABG for treatment of left main coronary artery disease. METHODS: In this prospective, randomised, open-label, non-inferiority trial, patients with left main coronary artery disease were enrolled in 36 centres in northern Europe and randomised 1:1 to treatment with PCI or CABG...
December 3, 2016: Lancet
https://www.readbyqxmd.com/read/27537567/mir-22-contributes-to-the-pathogenesis-of-patients-with-coronary-artery-disease-by-targeting-mcp-1-an-observational-study
#9
Bairong Chen, Liyun Luo, Weiping Zhu, Xiaoliang Wei, Songbiao Li, Yin Huang, Mao Liu, Xiufang Lin
The aim of this study is to determine miR-22 expression levels in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and to investigate whether MCP-1 expression is regulated by miR-22. miR-22 expression in PBMCs from 60 CAD patients including stable angina pectoris (SAP) (n = 29), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (NSTEMI) (n = 17), or ST-elevation MI (STEMI) (n = 14) and 20 non-CAD subjects by real-time polymerase chain reaction (qRT-PCR)...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27494404/hdac9-variant-rs2107595-modifies-susceptibility-to-coronary-artery-disease-and-the-severity-of-coronary-atherosclerosis-in-a-chinese-han-population
#10
Xue-Bin Wang, Ya-di Han, Shrestha Sabina, Ning-Hua Cui, Shuai Zhang, Ze-Jin Liu, Cong Li, Fang Zheng
A previous genome-wide association study showed that a single nucleotide polymorphism (SNP) rs2107595 in histone deacetylase 9 (HDAC9) gene was associated with large artery stroke (LAS) in Caucasians. Based on the similar atherosclerotic pathogenesis between LAS and coronary artery disease (CAD), we aimed to evaluate the associations of SNP rs2107595 with CAD risk and the severity of coronary atherosclerosis in a Chinese Han population, and explore the potential gene-environment interactions among SNP rs2107595 and conventional CAD risk factors...
2016: PloS One
https://www.readbyqxmd.com/read/27325227/coronary-plaque-rupture-with-subsequent-thrombosis-typifies-the-culprit-lesion-of-non-st-segment-elevation-myocardial-infarction-not-unstable-angina-non-st-segment-elevation-acute-coronary-syndrome-study
#11
Mikumo Sakaguchi, Shoichi Ehara, Takao Hasegawa, Kenji Matsumoto, Satoshi Nishimura, Junichi Yoshikawa, Kenei Shimada
Recently, unstable angina pectoris (UAP) and non-ST-segment-elevation myocardial infarction (NSTEMI) have been considered together because they exhibit indistinguishable clinical and electrocardiogram features, and constitute non-ST-segment-elevation acute coronary syndrome (NSTE-ACS). However, no optical coherence tomography (OCT) studies have reported the association between vulnerable plaque morphology and clinical characteristics in NSTE-ACS patients based on assessment of clinical symptoms and myocardial necrosis...
March 2017: Heart and Vessels
https://www.readbyqxmd.com/read/27313333/plasma-mir-10a-a-potential-biomarker-for-coronary-artery-disease
#12
Liyun Luo, Bairong Chen, Songbiao Li, Xiaoliang Wei, Tianmin Liu, Yin Huang, Xiufang Lin
Aims. MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD). The objective of this study is to determine plasma levels of miR-10a in CAD and analyze its association with the severity of CAD. Materials and Methods. Plasma miR-10a levels in 60 CAD patients including stable angina pectoris (SAP) (n = 29), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n = 17), or ST elevation MI (STEMI) (n = 14) and 20 non-CAD subjects were assessed by real-time polymerase chain reaction (qRT-PCR), and associations of miR-10a levels with risk factors of CAD and its severity were analyzed...
2016: Disease Markers
https://www.readbyqxmd.com/read/27166433/it-is-not-just-a-minor-thing-a-phenomenological-hermeneutic-study-of-patients-experiences-when-afflicted-by-a-minor-heart-attack-and-participating-in-cardiac-rehabilitation
#13
Charlotte P Simonÿ, Pia Dreyer, Birthe D Pedersen, Regner Birkelund
BACKGROUND: To improve cardiac care, especially cardiac rehabilitation, patients' perspectives should be better addressed. In Denmark, patients afflicted by a minor heart attack in terms of unstable angina pectoris or non-ST-elevation myocardial infarction are treated in fast-track programmes with subacute treatment in hospital, early discharge and follow-up specialised outpatient cardiac rehabilitation. Knowledge of these patients' experiences of their life situation is essential to develop sufficient care protocols...
June 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/26910053/the-use-of-echocardiography-in-certified-chest-pain-units-results-from-the-german-chest-pain-unit-registry
#14
Frank Breuckmann, Matthias Hochadel, Thomas Voigtländer, Michael Haude, Claus Schmitt, Thomas Münzel, Evangelos Giannitsis, Harald Mudra, Gerd Heusch, Burghard Schumacher, Sebastian Barth, Gerhard Schuler, Birgit Hailer, Dirk Walther, Jochen Senges
OBJECTIVES: To analyze the current usage of transthoracic echocardiography (TTE) as a rapid, noninvasive tool in the early stratification of acute chest pain in certified German chest pain units (CPUs). METHODS: A total of 23,997 patients were enrolled. Analyses comprised TTE evaluation rates in relation to clinical presentation, risk profile, left ventricular impairment, final diagnosis and invasive management. Critical times were assessed. Multivariable analyses for independent determinants for the use of TTE were performed...
2016: Cardiology
https://www.readbyqxmd.com/read/26894054/evaluation-of-serum-pregnancy-associated-plasma-protein-a-plasma-d-dimer-in-acute-coronary-syndrome
#15
Gautam Nichenametla, Vivian Samuel Thomas
INTRODUCTION: Acute coronary syndrome (ACS), a spectrum comprising unstable angina pectoris, ST Elevated Myocardial Infarction (STEMI) & Non ST Elevated Myocardial Infarction (NSTEMI) is the major cause of presentation in Emergency Department today. Though ECG and cardiac enzymes are used for diagnosis, they mislead the diagnosis sometimes and delay in treatment initiation. This leads us to search certain new parameters which reflect the pathophysiology of ACS. Markers of plaque stability like Pregnancy Associated Plasma Protein-A and D-Dimer, a marker of ongoing thrombosis are found to be better markers in early diagnosis...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26794722/invasive-versus-conservative-strategy-in-patients-aged-80-years-or-older-with-non-st-elevation-myocardial-infarction-or-unstable-angina-pectoris-after-eighty-study-an-open-label-randomised-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Nicolai Tegn, Michael Abdelnoor, Lars Aaberge, Knut Endresen, Pål Smith, Svend Aakhus, Erik Gjertsen, Ola Dahl-Hofseth, Anette Hylen Ranhoff, Lars Gullestad, Bjørn Bendz
BACKGROUND: Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris are frequent causes of hospital admission in the elderly. However, clinical trials targeting this population are scarce, and these patients are less likely to receive treatment according to guidelines. We aimed to investigate whether this population would benefit from an early invasive strategy versus a conservative strategy. METHODS: In this open-label randomised controlled multicentre trial, patients aged 80 years or older with NSTEMI or unstable angina admitted to 16 hospitals in the South-East Health Region of Norway were randomly assigned to an invasive strategy (including early coronary angiography with immediate assessment for percutaneous coronary intervention, coronary artery bypass graft, and optimum medical treatment) or to a conservative strategy (optimum medical treatment alone)...
March 12, 2016: Lancet
https://www.readbyqxmd.com/read/26772795/gender-specific-diagnostic-performance-of-a-new-high-sensitivity-cardiac-troponin-i-assay-for-detection-of-acute-myocardial-infarction
#17
Niklas Schofer, Fabian J Brunner, Michael Schlüter, Francisco Ojeda, Tanja Zeller, Stephan Baldus, Christoph Bickel, Karl J Lackner, Thomas Münzel, Stergios Tzikas, Sabine Genth-Zotz, Ascan Warnholtz, Felix Post, Till Keller, Britta U Goldmann, Stefan Blankenberg
BACKGROUND: The determination of cardiac troponin is essential for diagnosing myocardial infarction. A troponin I assay has recently been developed that provides the highest analytical sensitivity to date. METHODS: The analysis included 1560 patients with chest pain, of whom 1098 were diagnosed with non-coronary chest pain, 189 with unstable angina pectoris and 273 with non-ST-segment elevation myocardial infarction. The troponin I concentration was determined on admission (0 hours) and 3 hours later...
February 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/26341999/temporal-release-pattern-of-copeptin-and-troponin-t-in-patients-with-suspected-acute-coronary-syndrome-and-spontaneous-acute-myocardial-infarction
#18
Anna Slagman, Julia Searle, Christian Müller, Martin Möckel
BACKGROUND: The release pattern of copeptin during the initial 36 h of spontaneous acute myocardial infarction (AMI) has received relatively little investigation but may provide important information on optimal timing of diagnostic measurements. METHODS: We investigated the release pattern of copeptin and cardiac troponin T in patients with suspected acute coronary syndrome (ACS). Blood samples were collected in the ambulance, at admission, and after 2, 4, 6, and 12-36 h...
October 2015: Clinical Chemistry
https://www.readbyqxmd.com/read/26339610/different-plaque-composition-and-progression-in-patients-with-stable-and-unstable-coronary-syndromes-evaluated-by-cardiac-ct
#19
Maiken Glud Dalager, Morten Bøttcher, Jesper Thygesen, Gratien Andersen, Hans Erik Bøtker
OBJECTIVE: To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI). METHODS: Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26174605/impact-of-clinical-presentation-stable-angina-pectoris-vs-unstable-angina-pectoris-or-non-st-elevation-myocardial-infarction-vs-st-elevation-myocardial-infarction-on-long-term-outcomes-in-women-undergoing-percutaneous-coronary-intervention-with-drug-eluting
#20
COMPARATIVE STUDY
Gennaro Giustino, Usman Baber, Giulio Giuseppe Stefanini, Melissa Aquino, Gregg W Stone, Samantha Sartori, Philippe Gabriel Steg, William Wijns, Pieter C Smits, Raban V Jeger, Martin B Leon, Stephan Windecker, Patrick W Serruys, Marie-Claude Morice, Edoardo Camenzind, Giora Weisz, David Kandzari, George D Dangas, Ioannis Mastoris, Clemens Von Birgelen, Soren Galatius, Takeshi Kimura, Ghada Mikhail, Dipti Itchhaporia, Laxmi Mehta, Rebecca Ortega, Hyo-Soo Kim, Marco Valgimigli, Adnan Kastrati, Alaide Chieffo, Roxana Mehran
The long-term risk associated with different coronary artery disease (CAD) presentations in women undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is poorly characterized. We pooled patient-level data for women enrolled in 26 randomized clinical trials. Of 11,577 women included in the pooled database, 10,133 with known clinical presentation received a DES. Of them, 5,760 (57%) had stable angina pectoris (SAP), 3,594 (35%) had unstable angina pectoris (UAP) or non-ST-segment-elevation myocardial infarction (NSTEMI), and 779 (8%) had ST-segment-elevation myocardial infarction (STEMI) as clinical presentation...
September 15, 2015: American Journal of Cardiology
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