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Solitary Fibrous Tumor

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https://www.readbyqxmd.com/read/28413534/malignant-solitary-fibrous-tumour-of-orbit
#1
Hrishikesh Chakrabartty, Shashi Singhvi, Devendra Purohit, Radhey Shyam Mittal
Solitary fibrous tumor (SFT) is a rare neoplasm that is thought to be of mesenchymal origin. Occurrence of such a tumor in the orbit is rare, more so in its malignant form. Histopathologically, it can mimic several other tumors of the orbit and can be differentiated by CD34 positivity. We report a case of malignant transformation of an SFT of the orbit that recurred after 15 years. The differentiating histopathological features with special stress on the importance of CD34 positivity and principles of management are outlined...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28410845/-paraneoplastic-hypoglycemia-the-hopes-of-pathophysiological-documentation
#2
A Villemain, O Menard, D Mandry, J Siat, J-M Vignaud, Y Martinet, A Tiotiu
Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. These tumors are rare and usually asymptomatic. The syndrome of hypoglycemia is seen in less than 5% of the cases, and the associated tumors are large with a high mitotic rate. The cause of hypoglycemia is related to insulin-like growth factors produced by these tumors called "big" IGF-2. Several biological tests can demonstrate the increase of "big" IGF-2 plasma levels confirming the diagnosis of non-islet cell tumor induced hypoglycemia...
April 11, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28392706/pancreatic-solitary-fibrous-tumor-in-a-toddler-managed-by-pancreaticoduodenectomy-a-case-report-and-review-of-the-literature
#3
Qingfeng Sheng, Weijue Xu, Jiangbin Liu, Baiyong Shen, Xiaxing Deng, Yibo Wu, Wei Wu, Shenghua Yu, Xueli Wang, Zhibao Lv
Solitary fibrous tumor (SFT) of the pancreas is rare, with 15 adult cases reported in the English literature. We described a 14-month-old boy who presented with obstructive jaundice. Dominantly elevated serum CA19-9 was detected. Imaging studies revealed a well-circumscribed, solid mass in the pancreatic head. A pancreaticoduodenectomy (child procedure) was performed using Shen's anastomosis technique. After resection of the tumor, liver function and serum tumor markers normalized and clinical signs receded...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28389894/upper-fornix-approach-combined-with-a-superior-lateral-cantholysis-a-minimally-invasive-approach-to-the-superonasal-intraconal-space
#4
Ho-Seok Sa, Ji Won Seo, Sunah Kang
PURPOSE: To present a new minimally invasive approach to the deep superonasal orbit. METHODS: This retrospective study reviewed seven consecutive patients who underwent orbital surgery using an upper conjunctival fornix approach combined with a superior lateral cantholysis for tumors in the superonasal intraconal space. Charts were reviewed for demographic, radiological, clinical, and surgical data including surgical outcome and morbidities for each patient. RESULTS: Six benign tumors of the superonasal intraconal orbit were successfully exposed and removed using this approach, and one malignant tumor was biopsied for diagnosis...
April 7, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28376588/-expression-and-significance-of-stat6-in-solitary-fibrous-tumor
#5
Z Y Ding, Y F Wang, X Wang, Q Rao
Objective: To study the clinicopathologic features, the differential diagnosis and the expression of STAT6 in solitary fibrous tumor (SFT). Methods: Eighty cases of SFT were evaluated. The expression of STAT6, CD34, CD99 and bcl-2 protein was studied in these cases and in other groups of soft tissue tumors by immunohistochemical EnVision method. The results were analyzed and relevant literature were reviewed. Results: The expression rate of STAT6 in SFT was 97.5% (78/80) and that in other soft tissue tumors was 3...
April 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28368890/68ga-dotatoc-pet-ct-imaging-in-solitary-fibrous-tumor-of-the-pleura
#6
Filippo Lococo, Cristian Rapicetta, Massimiliano Casali, Salvatore Bellafiore, Giulio Rossi, Giorgio Treglia, Elisa Gasparini, Massimiliano Paci
Here we describe a 77-year-old man with a solitary fibrous tumor of the pleura showing increasing tracer uptake at Ga-DOTATOC PET/CT, demonstrating that solitary fibrous tumor of the pleura may overexpress somatostatin receptors, therefore mimicking neuroendocrine tumors at somatostatin receptor PET/CT.
March 31, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28352487/giant-perineal-solitary-fibrous-tumor-a-rare-case-report
#7
Petronio Augusto de Souza Melo, Ana Maria Yoshino Bonifaci, Fabio da Silva Crochik, Claudio Bovolenta Murta, Joaquim Francisco de Almeida Claro, Joao Padua Manzano
Background. Solitary fibrous tumor (SFT) is a fibroblastic mesenchymal tumor that was initially described from the pleura but currently arises at almost every anatomic site. It is usually benign, and surgical resection is curative. SFT involving the perineum is extremely rare. This is the third case report of a perineal SFT in the literature. Case Presentation. We reported an uncommon case of a 64-year-old man presenting with a huge perineal mass that started growing 3 years before his arrival in our service...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28340171/immunohistochemical-approach-to-the-differential-diagnosis-of-meningiomas-and-their-mimics
#8
Camille Boulagnon-Rombi, Clémence Fleury, Caroline Fichel, Sophie Lefour, Aude Marchal Bressenot, Guillaume Gauchotte
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA), progesterone receptor, somatostatin receptor 2A (SSTR2A), CD34, STAT6, S100, SOX10, HMB45, MelanA, GFAP, inhibin, and BCL2 antibodies. One hundred and twenty-seven meningiomas, 26 solitary fibrous tumor/hemangiopericytomas (SFT/HPC), 39 schwannomas, 17 hemangioblastomas, 21 melanomas, 9 gliosarcomas, 5 neurofibromas, 9 peripheral primitive neuroectodermal tumors, 7 synovial sarcomas, and 5 malignant peripheral nerve sheath tumors were included in the microarray...
April 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28339069/transglutaminase-2-is-upregulated-in-primary-hepatocellular-carcinoma-with-early-recurrence-as-determined-by-proteomic-profiles
#9
Hiromi Yamaguchi, Kazumichi Kuroda, Masahiko Sugitani, Tadatoshi Takayama, Kiyoshi Hasegawa, Mariko Esumi
The mechanism of early recurrence of hepato-cellular carcinoma (HCC) is not well understood. To examine whether early intrahepatic metastasis of HCC can be determined by the reliable molecular characteristics of the primary HCC, we focused on early-stage tumors of primary and solitary HCC cases. Proteomic differences were investigated between two groups, 11 early (recurrence within 12 months) and 10 late (no recurrence within 48 months) HCC cases, using two-dimensional fluorescence difference gel electrophoresis...
March 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28337357/solitary-fibrous-tumor-of-the-prostate-which-was-initially-misdiagnosed-as-prostate-cancer
#10
Soma Osamu, Hiromi Murasawa, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama
Solitary fibrous tumor (SFT) of the prostate is a very rare tumor. We report a case of 65-year-old man with SFT of the prostate which was initially misdiagnosed as prostate cancer. Finally, we performed total prostatectomy and the tumor was histologically diagnosed as SFT of the prostate. The patient's clinical course has progressed favorably with no obvious recurrence 18 months postoperatively.
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28326216/an-unusual-clinical-presentation-of-solitary-fibrous-tumor-in-the-oral-cavity
#11
Everton Freitas de Morais, Deborah Gondim Lambert Moreira, Viviane Alves De Oliveira, Rodrigo Rodrigues Rodrigues, Adriano Rocha Germano, Roseana de Almeida Freitas
Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28316298/solitary-fibrous-tumors-of-the-pleura-current-diagnostic-tools
#12
Robert R J Coebergh van den Braak, Klaas A Hartholt, Ben J Pannekoek, Frank Smedts, Maarten van der Elst
No abstract text is available yet for this article.
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28296778/malignant-solitary-fibrous-tumor-in-retroperitoneum-a-case-report-and-literature-review
#13
Yihong Zhou, Xi Chu, Ye Yi, Liang Tong, Yingbo Dai
RATIONALE: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor occurs in various sites. Malignant SFT in retroperitoneum is extremely rare. PATIENT CONCERNS: We report a case of malignant retroperitoneal SFT in a 59-year-old man presented with right flank pain for 1 month. DIAGNOSES, INTERVENTIONS AND OUTCOMES: A laparotomy and resection of the tumor were performed, the histopathologic and immunohistochemical findings were consistent with malignant retroperitoneal SFT...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28293014/-intrapulmonary-solitary-fibrous-tumor-report-of-a-case
#14
Yoshimasa Tokunaga, Taku Okamoto, SungSoo Chang
An abnormal lung shadow was detected in a 39-year-old woman at physical examination and she was followed-up carefully at a nearby hospital. After 5 years follow-up, the patient was referred to our hospital for further examination of the abnormal shadow. A chest computed tomography(CT) scan revealed a 12 mm well-circumscribed nodular shadow in the right lower lobe. A benign tumor such as a hamartoma was suspected preoperatively;video-assisted thoracic surgery was performed for both diagnosis and treatment. Partial resection of the right lower lobe was performed and the tumor was diagnosed as an intrapulmonary solitary fibrous tumor (SFT)...
March 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28288036/gist-manifesting-as-a-retroperitoneal-tumor-clinicopathologic-immunohistochemical-and-molecular-genetic-study-of-112-cases
#15
Markku Miettinen, Anna Felisiak-Golabek, Zengfeng Wang, Shingo Inaguma, Jerzy Lasota
Most gastrointestinal stromal tumors (GISTs) occur in the tubular gastrointestinal (GI) tract, but some present apparently outside the GI tract. In this study, we analyzed 112 GISTs located in the retroperitoneum. These tumors occurred in 55 women and 57 men with a median age of 65 years (range: 21 to 89 y). On the basis of clinically or histologically detected connections to GI tract, 15 tumors were considered likely of gastric, 9 duodenal, and 13 of small intestinal origin. The remaining cases were categorized by location as peripancreatic (n=25), pelvic (n=11), mesenteric (n=4), and of unspecified/miscellaneous sites (n=35)...
May 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28286800/solitary-fibrous-tumor-of-the-stomach
#16
Faisal Inayat, Qulsoom Hussain, Khurram Shafique, Abu Hurairah, Evan B Grossman
Solitary fibrous tumor is a rare mesenchymal neoplasm that usually originates from the pleura, but has been reported in other extrapleural locations. We report a rare case of a solitary fibrous tumor of the stomach, which was successfully treated with endoscopic mucosal resection.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28272656/solitary-fibrous-tumor-of-the-vagina-with-potentially-malignant-features-a-case-report-and-review-of-the-literature
#17
Asuman Reyhan
Extrapleural solitary fibrous tumors are being increasingly reported. The retroperitoneum, deep soft tissues of the proximal extremities, abdominal cavity, trunk, head and neck are among the most common extraserosal locations reported. A recurrent solitary fibrous tumor involving the vagina of a 25-year-old woman is reported. Microscopically, the tumor was hypercellular and composed of mitotically active spindle cells. Immunohistochemically, the tumor cells were positive for vimentin, CD34, and bcl-2. Four cases of solitary fibrous tumors involving the vagina have been reported previously...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28253927/low-tissue-levels-of-mir-125b-predict-malignancy-in-solitary-fibrous-tumors-of-the-pleura
#18
Matthias Brock, Selma Hottinger, Matthias Diebold, Alex Soltermann, Wolfram Jochum, Malcolm Kohler, Lars C Huber, Daniel P Franzen
BACKGROUND: Solitary fibrous tumors of the pleura (SFTP) are rare neoplasia of the chest. A subset of SFTP follows a malignant course, sometimes several years after complete resection. Traditional scoring systems based on clinical and histological features are poor predictors of biological behavior. This study aimed to investigate tumor-associated miRNAs expression as novel biomarkers to predict the clinical behavior of SFTP. METHODS: Formalin-fixed and paraffin-embedded SFTP tissues blocks from patients surgically resected between 1992 and 2013 at two tertiary care teaching hospitals were included...
March 2, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28252420/metaphyseal-cortical-defect-and-tumor-like-processes-of-long-bones-a-literature-review-and-own-observations
#19
REVIEW
N Lysenko, Ye Sharmazanova, I Voronzhev, A Sorochan, Yu Kolomiychenko
Metaphyseal cortical defect (metaphyseal fibrous defect, cortical fibrous defect) of the long bones is a quite common variant of the bone structure's pathologic changes. The cortical defects and similar to their tumor-like processes (non-ossifying fibroma, benign fibrous histiocytoma etc.) are characterized by particular qualities of the clinical symptoms and radiologic signs. The aim of this article is to analyze a known literature data about cortical fibrous defects of long bones and similar to their tumor-like processes and present results of our own observations...
January 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28250642/malignant-solitary-fibrous-tumor-of-thoracic-spine-with-distant-metastases-second-reported-case-and-review-of-the-literature
#20
Rituparna Biswas, Anirban Halder, Prashant P Ramteke, Rambha Pandey
Solitary fibrous tumor (SFT) usually originates from the pleura because of abnormal proliferation of fibroblast cells. It is extremely rare for the tumor to originate from the spine. Here, we report the second case of malignant SFT of thoracic spine with distant metastases in a 35-years-old female.
January 2017: Journal of Craniovertebral Junction and Spine
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