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Solitary Fibrous Tumor

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https://www.readbyqxmd.com/read/29689243/whole-exome-sequencing-identifies-unique-mutations-and-copy-number-losses-in-calcifying-fibrous-tumor-of-the-pleura-report-of-three-cases-and-review-of-the-literature
#1
Mitra Mehrad, William A LaFramboise, Maureen A Lyons, Humberto E Trejo Bittar, Samuel A Yousem
Calcifying fibrous tumor of the pleura (CFTP) is a rare mesenchymal tumor of unknown pathogenesis. The diagnosis often requires exclusion of other common entities. Our aim was to determine if genomic changes were associated with CFTP that could contribute to mechanisms underlying tumorigenesis. Three cases of CFTP with their corresponding uninvolved control lung tissue were identified. Two patients were male, and one was female (age range: 21-32years). Tumors were multifocal in two cases and solitary in one...
April 21, 2018: Human Pathology
https://www.readbyqxmd.com/read/29682137/solitary-fibrous-tumor-of-the-ischioanal-fossa-a-multidisciplinary-approach-to-management-with-radiologic-pathologic-correlation
#2
A Bhat, L J Layfield, S O Tewari, A H Gaballah, R Davis, Z Wu
Solitary fibrous tumors are primary mesenchymal tumors, which may occur in any part of the body. Overall, these tumors are considered to have intermediate malignant potential with 5- and 10-year metastasis-free and overall disease-specific survival rates of 74% and 55%, and 89% and 73%, respectively (Demicco et al, 2012). Herein we present an unusual case of solitary fibrous tumors involving the ischioanal fossa in a 19-year-old woman with radiologic-pathologic correlation. This case was complicated by extensive tumor vascularity and was thus managed with preoperative embolization followed by en bloc surgical resection...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29682136/metastatic-cervical-paravertebral-solitary-fibrous-tumor-detected-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#3
Hoiwan Cheung, Courtney Lawhn-Heath, Giselle Lopez, Maya Vella, Carina Mari Aparici
Solitary fibrous tumor/hemangiopericytomas (SFT/HPC) are soft tissue tumors that can arising from the abomen, pleura, head and neck, or extremities. We report an unusual case of recurrent hemangiopericytoma in a 67-year-old female presenting with a painless and palpable mass within her right posterior neck. Eight years after initial resection of the mass, a follow-up MRI showed multiple enlarging calvarial lesions. A whole body FDG-PET/CT revealed not only hypermetabolic calvarial lesions but also numerous hypermetabolic axillary node and osseous metastases...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29682031/solitary-fibrous-tumors-of-the-orbit-and-central-nervous-system-a-case-series-analysis
#4
Marisa Brum, Hipólito Nzwalo, Edson Oliveira, Maria Rita Pelejão, Pedro Pereira, João Paulo Farias, José Pimentel
Introduction: Solitary fibrous tumor (SFT) is rarely diagnosed in clinical practice. Since its initial descriptions in the central nervous system (CNS) and the orbits, very few case reports and small case series have expanded their clinical and pathological characterization. We sought to describe a cases series of SFT from a single laboratory of neuropathology belonging to a tertiary university hospital. Methods: Retrospective clinical and histopathological description of eight cases of CNS and orbital SFT diagnosed over a 21-year period of time...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29675794/association-between-programmed-cell-death-ligand-1-expression-and-extracranial-metastasis-in-intracranial-solitary-fibrous-tumor-hemangiopericytoma
#5
Dai Kamamoto, Kentaro Ohara, Yohei Kitamura, Kazunari Yoshida, Yutaka Kawakami, Hikaru Sasaki
BACKGROUND: Intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) often shows extracranial metastasis, and treatment options are very limited. Immune-checkpoint molecules have not been studied well in SFT/HPCs, and their role in intracranial SFT/HPCs remains unclear. METHODS: We investigated the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and tumor-infiltrating lymphocytes (TIL) in 16 patients of intracranial SFT/HPC by immunohistochemistry to determine if correlation with prognosis exists...
April 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29675063/chylothorax-after-endoscopic-ultrasound-with-fine-needle-aspiration-causing-migrating-appearance-of-a-solitary-fibrous-tumor-of-the-pleura
#6
Francesco Mongelli, Maurice FitzGerald, Stefano Cafarotti, Rolf Inderbitzi
Trans-esophageal endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is widely used to assess mediastinal masses. Common complications are self-limiting bleeding or pain, but occasionally, more serious accidents have been reported. A 54-year-old woman with a huge mass located in the left middle mediastinum presented 2 days after an EUS-FNA with dyspnea and chest pain. Computed tomography scan showed a massive left pleural effusion. A chest tube was inserted revealing a chylothorax (1800 ml). Over the following days, the pleural effusion did not diminish, requiring a left mini-thoracotomy...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29660566/extrapleural-solitary-fibrous-tumor-a-distinct-entity-from-pleural-solitary-fibrous-tumor-an-update-on-clinical-molecular-and-diagnostic-features
#7
REVIEW
Andrea Ronchi, Immacolata Cozzolino, Federica Zito Marino, Marina Accardo, Marco Montella, Iacopo Panarese, Giuseppe Roccuzzo, Giorgio Toni, Renato Franco, Annarosaria De Chiara
Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that was originally described to be localized in the pleura, but thereafter, this has been reported in several anatomic sites. Although the etiology of the neoplasm remains largely unknown, the pathogenesis seems to be related to an NAB2-STAT6 fusion gene due to paracentric inversion on chromosome 12q13. The diagnosis of extrapleural SFT is challenging, owing to its rarity, and requires an integrated approach that includes specific clinical, histological, immunohistochemical, and even molecular findings...
April 9, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29620517/solitary-fibrous-tumor-of-the-kidney-treated-with-laparoscopic-partial-nephrectomy-a-case-report
#8
Xing Chen, Jian-Feng Wang, Zhen-Shan Ding, Xiao-Feng Zhou
We herein reported a 27-year-old woman with a right renal mass for two years. She underwent laparoscopic partial nephrectomy. Immunohistochemical examination of the specimen confirmed the diagnosis of solitary fibrous tumor by revealing its positive staining for cluster of differentiation (CD)34, epithelial membrane antigen (EMA), B-cell lymphoma-2 (Bcl-2) and CD99 in the tumor cells. No adjuvant treatment was carried out. The patient was in good health without local recurrence or metastasis during 2 years of follow-up...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29616597/malignant-solitary-fibrous-tumor-metastatic-to-widely-invasive-hurthle-cell-thyroid-carcinoma-a-distinct-tumor-to-tumor-metastasis
#9
Eva Kolson Kokohaare, Francesco M G Riva, Jonathan M Bernstein, Aisha B Miah, Khin Thway
We illustrate a case of synchronous malignant solitary fibrous tumor of the thoracic cavity, and widely invasive thyroid Hurthle cell carcinoma. The Hurthle cell carcinoma was found to harbor distinct areas of malignant solitary fibrous tumor. This is a unique case of tumor-to-tumor metastasis that, to the best of our knowledge, has not been previously reported.
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29614488/efficacy-and-safety-of-pazopanib-for-recurrent-or-metastatic-solitary-fibrous-tumor
#10
Takahiro Ebata, Tatsunori Shimoi, Seiko Bun, Mototaka Miyake, Akihiko Yoshida, Akihiko Shimomura, Emi Noguchi, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Yoshitaka Narita, Kenji Tamura
OBJECTIVE: To investigate the efficacy and safety of pazopanib for recurrent or metastatic solitary fibrous tumor (SFT) in first- and second-line settings. METHODS: Patients histologically diagnosed with SFT at our hospital who received pazopanib monotherapy for inoperable disease between January 2013 and November 2016 were eligible. We retrospectively investigated treatment outcomes according to the treatment lines and assessed adverse events. RESULTS: Nine patients were eligible...
April 3, 2018: Oncology
https://www.readbyqxmd.com/read/29613962/mr-imaging-of-pleural-neoplasms
#11
Brett W Carter, Sonia L Betancourt, Girish S Shroff, John P Lichtenberger
The pleura may be affected by primary tumors or metastatic spread of intrathoracic or extrathoracic neoplasms. Primary pleural neoplasms represent ∼10% of all pleural tumors, and malignant lesions are more common than benign lesions. The most common primary tumors include malignant pleural mesothelioma and solitary fibrous tumor. Although pleural neoplasms may initially be evaluated with computed tomography (CT) and/or fluorodeoxyglucose positron emission tomography (PET)/CT, magnetic resonance (MR) imaging is complementary to these other imaging modalities for disease staging and evaluation of patients...
April 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29600523/grading-of-meningeal-solitary-fibrous-tumors-hemangiopericytomas-analysis-of-the-prognostic-value-of-the-marseille-grading-system-in-a-cohort-of-132-patients
#12
Nicolas Macagno, Rob Vogels, Romain Appay, Carole Colin, Karima Mokhtari, Benno Küsters, Pieter Wesseling, Dominique Figarella-Branger, Uta Flucke, Corinne Bouvier
The finding that meningeal solitary fibrous tumors (SFTs) and meningeal hemangiopericytomas (HPCs) are both characterized by NAB2-STAT6 gene fusion has pushed their inclusion in the WHO 2016 Classification of tumors of the central nervous system (CNS) as different manifestations of the same entity. Given that the clinical behavior of the CNS SFT/HPC spectrum ranges from benign to malignant, it is presently unclear whether the grading criteria are still adequate. Here, we present the results of a study that analyzed the prognostic value of an updated version of the Marseille Grading System (MGS) in a retrospectively assembled cohort of 132 primary meningeal SFTs/HPCs with nuclear overexpression of STAT6...
March 30, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29595682/salvage-preoperative-embolization-of-an-infratemporal-solitary-fibrous-tumor-a-case-report-with-review-of-the-literature
#13
Kabalane Yammine, Haydar A Nasser, Usama Hadi, Mohamad Ali Natout, Vicky Najjar, Claude Tayar
RATIONALE: Head and Neck Solitary fibrous tumors (SFT) are very rare. They could be misdiagnosed as hemangiopericytomas (HPC). PATIENT CONCERNS: We report a 60 y o lady presenting with sinonasal mass, causing recurrent profuse bleeding. DIAGNOSES: Hemangioperocytomas versus SFT were among the differentials, according to Radiological studies. Upon Biopsy, the diagnosis of SFT has been adopted. INTERVENTIONS: Salvage pre-operative embolization resulted in bleeding control, bridging the patient to surgery...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29566950/biphenotypic-sinonasal-sarcoma-a-series-of-six-cases-with-evaluation-of-role-of-%C3%AE-catenin-immunohistochemistry-in-differential-diagnosis
#14
Aanchal Kakkar, Madhu Rajeshwari, Pirabu Sakthivel, Mehar C Sharma, Suresh C Sharma
INTRODUCTION: Biphenotypic sinonasal sarcoma (BSNS) is a recently described mesenchymal tumor exclusive to the sinonasal region. It is a low grade sarcoma, displaying evidence of myogenic and neural differentiation. Role of β-catenin immunohistochemistry in distinguishing it from its morphological mimics is not well-established. We conducted this study to identify cases of BSNS from our archives, and to examine immunopositivity for β-catenin in them as well as in its close differential diagnosis...
April 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29556387/management-consideration-for-patient-with-a-large-solitary-fibrous-tumor-occupying-the-infratemporal-fossa-a-case-report
#15
Makoto Adachi, Masayuki Motohashi, Yasuhiko Kaku, Shigeyuki Sugie, Yasunori Muramatsu, Shinichiro Sumitomo
The solitary fibrous tumor (SFT) was first described as a mesenchymal tumor of fibroblastic type, present in the pleura. The head and neck area is the third most common site of SFT occurrence. Numb chin syndrome (NCS) is a rare neurological symptom. The current report describes the case of a 39-year-old female patient referred to the present hospital with NCS, which was later observed to be due to a large SFT in the infratemporal fossa. Computed tomography and magnetic resonance images were taken and subsequent examination of these images revealed a space occupying mass (52×50×40 mm) in the infratemporal fossa...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29555080/non-islet-cell-tumour-hypoglycaemia-nicth-about-a-series-of-6-cases
#16
Arnaud Jannin, Stéphanie Espiard, Kanza Benomar, Christine Do Cao, Bénédicte Mycinski, Henri Porte, Michèle D'Herbomez, Nicolas Penel, Marie-Christine Vantyghem
The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic secretion of IGF-2 or its related substances. RESULTS: Three of these 6 patients (50%), aged over 69 years, including 2 with acromegaloid phenotype, presented with a pleural solitary fibrous tumor (SFT), with median diameter 20 cm (interquartile range, 12.5-20.5) with a low median SUV (3...
March 16, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29554391/presumed-solitary-circumscribed-retinal-astrocytic-proliferation-in-the-fovea-with-oct-angiography-a-misnomer
#17
Roger A Goldberg, Katherine M Raja
The retinal lesion known as the presumed solitary circumscribed retinal astrocytic proliferation (pSCRAP) is a benign retinal tumor. Although many of the clinical characteristics of the lesion have been described, much about the pathogenesis of this uncommon tumor is not yet known. Here, the authors report a pSCRAP lesion in the fovea with secondary vision loss occurring in middle age. Structural optical coherence tomography (OCT) scans indicate that the lesion arises from the deep retina or retinal pigment epithelium (RPE), whereas OCT angiography characteristics of the lesion show a lack of intrinsic or paralesional vascular flow, indicating that this lesion is fibrous and likely derived from the RPE or deep retina and not the retinal astrocytes...
March 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29551003/surveillance-for-metastatic-hemangiopericytoma-solitary-fibrous-tumors-systematic-literature-review-on-incidence-predictors-and-diagnosis-of-extra-cranial-disease
#18
REVIEW
Tarini Ratneswaren, Florence Rosie Avila Hogg, Mathew Joseph Gallagher, Keyoumars Ashkan
BACKGROUND: Intracranial hemangiopericytomas (HPC) and solitary fibrous tumors (SFTs) (HPC-SFT) are rare vascular tumors that resemble meningioma on imaging and predominantly affect young adults. HPC-SFT have a high rate of local recurrence with well-known propensity for extracranial metastases. This provides clinical dilemmas frequently encountered in oncology: (i) How should these patients be monitored long term? (ii) Which primary tumors are more likely to metastasize? OBJECTIVES: This systematic review aims to identify the incidence, common locations and time to presentation of extra-cranial metastases of HPC-SFT...
March 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29545054/solitary-fibrous-tumor-of-the-pelvis-involving-the-urinary-bladder
#19
Megan C Prunty, Ayman Gaballah, Lindsey Ellis, Katie S Murray
No abstract text is available yet for this article.
March 12, 2018: Urology
https://www.readbyqxmd.com/read/29526941/late-onset-of-non-islet-cell-tumor-hypoglycemia-managed-via-multidisciplinary-treatment-in-a-patient-with-a-solitary-fibrous-tumor
#20
Satoshi Takeuchi, Tomohiro Goda, Jun Taguchi, Yuichi Douhata, Rio Honma, Shin Ariga, Yoshihito Ohhara, Yasushi Shimizu, Ichiro Kinoshita, Izumi Fukuda, Yoji Nagashima, Hirotoshi Akita
Solitary fibrous tumor (SFT) is a rare subtype of soft tissue sarcoma (STS). We herein describe a case of late onset of non-islet cell tumor hypoglycemia (NICTH) that was managed via multidisciplinary treatment in a patient with SFT. A 67-year-old man previously diagnosed with SFT 4 years prior to this presentation and treated with several rounds of surgery, presented with massive tumors. Eighteen months following his prescribed chemotherapy, the patient developed hypoglycemia. He was diagnosed with NICTH, after confirming the presence of high molecular weight insulin-like growth factor-2...
March 9, 2018: Internal Medicine
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