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Solitary Fibrous Tumor

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https://www.readbyqxmd.com/read/28818175/solitary-fibrous-tumor-hemangiopericytoma-of-palate-report-of-a-case-with-immunohistochemical-interpretation-using-cd-34
#1
Manas Bajpai, Nilesh Pardhe, Betina Chandolia, Manika Arora
No abstract text is available yet for this article.
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28816553/a-rare-case-of-giant-multicystic-solitary-fibrous-tumor-of-the-orbit
#2
Shahid Alam, Varsha Backiavathy, Bipasha Mukherjee, Krishnakumar Subramanian
Solitary fibrous tumor (SFT) is a rare spindle cell tumor of the orbit of mesenchymal origin. Though these tumors are mostly solid, partial or complete cystic changes can rarely occur. Only six such previous cases of cystic fibrous tumor of the orbit have been mentioned in the literature. We report a case of an elderly male who presented with a huge left sided medial orbital mass. Magnetic resonance imaging showed a predominant cystic orbital mass separated by septae and suggested a diagnosis of Hydatid cyst...
August 17, 2017: Orbit
https://www.readbyqxmd.com/read/28803175/seeding-of-abdomen-with-primary-intracranial-hemangiopericytoma-by-a-ventriculoperitoneal-shunt-case-report
#3
Kelly Bridges, Rebecca Sauerwein, Marjorie Grafe, Vassiliki Liana Tsikitis, Aaron Halfpenny, Ahmed Raslan
BACKGROUND: Ventriculoperitoneal shunt (VPS) placement has been implicated in extraneural metastasis of many primary central nervous system tumors. Reported cases include, but are not limited to, medulloblastoma, germ cell tumor, astrocytoma, oligodendroglioma, lymphoma, ependymoma, melanoma, and choroid plexus tumors. However, a literature review reveals no reported cases of extraneural metastasis of solitary fibrous tumor/hemangiopericytoma (SFT/HPC). CASE DESCRIPTION: Here we report the case of a 34-year-old man with recurrent intracranial malignant SFT/HPC who had undergone surgical tumor resection and subsequent placement of a VPS for obstructive hydrocephalus in 2004...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28802503/fibrohistiocytic-tumors
#4
REVIEW
Ryan C Romano, Karen J Fritchie
Fibrohistiocytic tumors are a diverse group of reactive and neoplastic lesions including xanthoma, fibrous histiocytoma and its variants, solitary xanthogranuloma, dermatofibrosarcoma protuberans, and atypical fibroxanthoma. This article reviews some of the more commonly encountered fibrohistiocytic tumors with an emphasis on clinical presentation, macroscopic and histologic characteristics, molecular/cytogenetic findings where applicable, and differential diagnoses.
September 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28781839/ileum-preserving-expanded-jejunectomy-and-pancreaticoduodenectomy-with-combined-resection-of-the-superior-mesenteric-artery-for-huge-retroperitoneal-solitary-fibrous-tumor
#5
Akinori Egashira, Yasuharu Ikeda, Masaru Morita, Ken-Ichi Taguchi, Nao Kinjyo, Eiji Tsujita, Kazuhito Minami, Manabu Yamamoto, Yasushi Toh
We encountered a patient with a large retroperitoneal solitary fibrous tumor, in whom we could preserve approximately 150 cm of the ileum even after pancreaticoduodenectomy combined with resection of the superior mesenteric artery, thus preventing short bowel syndrome.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28766950/imaging-features-of-rare-mesenychmal-liver-tumors-beyond-hemangiomas
#6
Rajesh Thampy, Khaled M Elsayes, Christine O Menias, Perry J Pickhardt, Hyunseon C Kang, Sandeep Deshmukh, Kareem Ahmed, Brinda Rao Korivi
Tumors arising from mesenchymal tissue components such as vascular, fibrous and adipose tissue can manifest in the liver. Although histopathology is often necessary for definitive diagnosis, many of these lesions exhibit characteristic imaging features. The radiologist plays an important role in suggesting the diagnosis, which can direct appropriate immunohistochemical staining at histology. The aim of this review is to present clinical and imaging findings of a spectrum of mesenchymal liver tumors such as hemangioma, epithelioid hemangioendothelioma, lipoma, PEComa, angiosarcoma, inflammatory myofibroblastic tumor, solitary fibrous tumor, leiomyoma, leiomyosarcoma, Kaposi sarcoma, mesenchymal hamartoma, undifferentiated embryonal sarcoma, rhabdomyosarcoma and hepatic metastases...
August 2, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28763695/anterior-mediastinal-solitary-fibrous-tumor-resection-by-da-vinci-%C3%A2-surgical-system-in-obese-patient
#7
Dario Amore, Marco Rispoli, Marcellino Cicalese, Ilaria De Rosa, Giuseppe Rossi, Antonio Corcione, Salvatore Buono, Carlo Curcio
INTRODUCTION: Solitary fibrous tumors are uncommon soft tissue tumors initially reported only in the pleura but, in recent years, they have been described at many extra pleural sites, such as mediastinum. The treatment of choice is the extensive surgical resection that is curative for most benign lesions. PRESENTATION OF THE CASE: We present the case of solitary fibrous tumor of the anterior mediastinum in obese patient (BMI: 34.3) undergoing complete surgical resection by robotic-assisted thoracoscopic surgery with da Vinci(®) Surgical System...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28760129/management-of-solitary-fibrous-tumors-localized-in-extremity-case-series-and-a-review-of-the-literature
#8
Recep Öztürk, Şefik Murat Arıkan, Mehmet Akif Şimşek, Emre Özanlağan, Bedii Şafak Güngör
OBJECTIVES: This study aims to evaluate the clinical characteristics and treatment results of patients with a diagnosis of solitary fibrous tumor localized in extremity. PATIENTS AND METHODS: Clinical findings, treatment methods, clinical outcomes and treatment failures of seven patients (3 males, 4 females; mean age 49.7±20.7 years; range 22 to 79 years) diagnosed as solitary fibrous tumor localized in extremity between January 2005 and December 2016 were evaluated retrospectively...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28759137/soft-tissue-sarcomas-from-a-morphological-to-a-molecular-biological-approach
#9
REVIEW
Yoshinao Oda, Hidetaka Yamamoto, Kenichi Kohashi, Yuichi Yamada, Kunio Iura, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki
Recently developed molecular genetic techniques have led to the elucidation of tumor-specific genomic alterations and thereby the reclassification of tumor entities of soft tissue sarcoma. A solitary fibrous tumor-mimicking tumor with the AHRR-NCOA2 gene has been isolated as angiofibroma of soft tissue. As for small round cell sarcomas, novel fusion genes such as CIC-DUX4 and BCOR-CCNB3 have been identified in these tumor groups. SMARCB1/INI1 deficient tumors with round cell morphology are also expected to be reclassified in three types, based on the combination of their morphology and genotype...
July 31, 2017: Pathology International
https://www.readbyqxmd.com/read/28749793/pax8-expression-in-solitary-fibrous-tumor-a-potential-diagnostic-pitfall
#10
David Ullman, Jennifer Gordetsky, Gene P Siegal, Carlos N Prieto-Granada, Shi Wei, Todd M Stevens
PAX8 is used as a diagnostic aid in classifying retroperitoneal (RP) spindle cell tumors. PAX8 positivity in a spindled RP tumor is typically associated with sarcomatoid renal cell carcinoma (SRCC). However, PAX8 expression in solitary fibrous tumor (SFT), a tumor not uncommon to the RP, has not been extensively studied. We investigated the expression of PAX8 in SFTs and other spindle cell RP tumors. We collected 30 SFT, 23 SRCC, 11 gastrointestinal stromal tumors, 2 synovial sarcomas, 6 dedifferentiated liposarcomas (DDLS), 4 well differentiated liposarcomas (WDLS), and select other tumors...
July 26, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28734445/primary-solitary-fibrous-tumor-of-the-forearm-with-frequent-late-onset-recurrence-in-the-pleura
#11
Yoko Yamamoto, Ryu Kanzaki, Masayoshi Inoue, Meinoshin Okumura
Solitary fibrous tumor (SFT) is a relatively rare form of mesenchymal tumor that generally has a benign clinical course. However, SFTs have malignant potential. We report the case of a 36-year-old man with local relapse and frequent late-onset pleural metastasis of primary SFT of the forearm. Pleural metastasis was first seen 11 years after the initial operation. During a 17-year period, he underwent 5 surgical resections. He has been free of disease for 61 months since the most recent operation.
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28731041/risk-assessment-in-solitary-fibrous-tumors-validation-and-refinement-of-a-risk-stratification-model
#12
Elizabeth G Demicco, Michael J Wagner, Robert G Maki, Vishal Gupta, Ilya Iofin, Alexander J Lazar, Wei-Lien Wang
Solitary fibrous tumors are an uncommon sarcoma type characterized by NAB2-STAT6 gene fusion. While solitary fibrous tumors metastasize in 5-25% of cases, it has historically been challenging to determine which specific tumor and patient characteristics predict aggressive behavior. We previously reported on a novel risk stratification scheme for solitary fibrous tumors incorporating patient age, tumor size, and mitotic activity to predict risk of metastasis. Herein we validate this risk stratification scheme in an independent, lower-risk population of 79 patients with primary non-meningeal solitary fibrous tumors, and propose incorporating tumor necrosis as a fourth variable to further improve the risk score...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28728219/-solitary-fibrous-tumor-hemangiopericytoma-of-central-nervous-system-a-clinicopathologic-analysis-of-71-cases
#13
X L Li, W W Fu, S Zhang, D Y Chen, Y P Chen, J Wu, X Y Liu, G P Li, S M Lin, S Luo, S S Cai, W Guo, X F Wang
Objective: As solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) share the same molecular genetics features, the 2016 WHO classification of central nervous system (CNS) tumors had created the combined term SFT/HPC and assigns three grades. This study aims to investigate the clinicopathologic characteristics, diagnosis, differential diagnosis and prognosis of CNS SFT/HPC. Methods: Seventy-one cases of CNS SFT and HPC were retrospectively reclassified and studied. Histopathological, immunohistochemical and imaging features were analyzed...
July 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28698430/-extralobar-sequestration-difficult-to-establish-preoperative-diagnosis-report-of-a-case
#14
Michiru Sato, Satoshi Shiono, Katsuyuki Suzuki, Kei Yarimizu, Kazuki Hayasaka, Makoto Endo, Naoki Yanagawa
Pulmonary sequestration is a rare congenital pulmonary anomaly. Here we report a case of extralobar sequestration with calcification. A 34-year-old man was admitted to our department because of a tumor shadow on the chest radiological examination. Computed tomography examination revealed a mass measuring 5 cm above the left diaphragm. The mass contained cysts and calcification. Aberrant vessels were not detected. Teratoma, hamartoma or solitary fibrous tumor were suspected and the surgical treatment was performed...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28689369/stat6-reliably-distinguishes-solitary-fibrous-tumors-from-myofibromas
#15
Molly Housley Smith, Nadim M Islam, Indraneel Bhattacharyya, Donald M Cohen, Sarah G Fitzpatrick
Solitary fibrous tumors (SFT) and myofibromas (MF) historically have belonged to the same morphologic spectrum and have been lumped together under the nonspecific umbrella term, "hemangiopericytoma" along with other pericytic/myoid tumors. While current evidence shows clear distinction between the two entities, they frequently remain in the same histopathologic differential diagnosis. This diagnostic dilemma especially is common for smaller incisional biopsies from the oral cavity. STAT6 immunohistochemistry (IHC) recently was established as a reliable method to detect solitary fibrous tumor; however, the literature is sparse regarding STAT6 reactivity in MFs...
July 8, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28687087/a-rare-case-of-malignant-solitary-fibrous-tumor-in-prostate-with-review-of-the-literature
#16
Andrea Ronchi, Elvira La Mantia, Vincenzo Gigantino, Sisto Perdonà, Marco De Sio, Gaetano Facchini, Renato Franco, Annarosaria De Chiara
BACKGROUND: Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described in the prostate. The present case is characterized by some peculiarities if compared with previously reported cases of prostatic malignant solitary fibrous tumor. Firstly, it does not show a homogeneous morphology: part of the neoplasm (about 50%) showed the features of a conventional solitary fibrous tumor, while the remaining part showed the features of a malignant solitary fibrous tumor...
July 7, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28682900/doege-potter-syndrome-a-review-of-the-literature-including-a-new-case-report
#17
REVIEW
Guiyan Han, Zhimin Zhang, Xingbin Shen, Kunpeng Wang, Yang Zhao, Jianqiu He, Yu Gao, Xiujie Shan, Guohua Xin, Chunhui Li, Xiaoyan Liu
RATIONALE: We reviewed 76 published cases of Doege-Potter syndrome, and non-islet cell tumor hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT) between 1989 and 2016, to study disease pathogenesis, diagnosis, and treatment of this rare paraneoplastic disease. Further, we report 1 new case of a patient presenting with Doege-Potter syndrome. PATIENTS CONCERNS: The tumors originated from the pleural cavity, lung, pelvis, liver, retroperitoneum, kidney, mediastinal, the sella, uterus, bladder, intestine, mandibular, and the thigh...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28680608/surgically-cured-paraneoplastic-hypoglycemia-associated-with-solitary-fibrous-tumor-of-the-pleura-report-of-two-cases
#18
Ryuta Fukai, Yoshihito Irie, Hiroyoshi Watanabe
Hypoglycemia is seldom seen in association with insulinomas, rare autoimmune diseases, and paraneoplastic situations. Paraneoplastic hypoglycemia is known as nonislet cell tumor-induced hypoglycemia (NICTH). It is also known that a solitary fibrous tumor of the pleura can cause NICTH and that surgical resection is crucial to the success of NICTH treatment.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28662235/use-of-pd-1-targeting-macrophage-infiltration-and-ido-pathway-activation-in-sarcomas-a-phase-2-clinical-trial
#19
Maud Toulmonde, Nicolas Penel, Julien Adam, Christine Chevreau, Jean-Yves Blay, Axel Le Cesne, Emmanuelle Bompas, Sophie Piperno-Neumann, Sophie Cousin, Thomas Grellety, Thomas Ryckewaert, Alban Bessede, François Ghiringhelli, Marina Pulido, Antoine Italiano
Importance: There is a strong rationale for treating sarcomas with immunotherapy. Objective: To assess the efficacy and safety of programmed cell death protein 1 (PD-1) targeting in combination with metronomic chemotherapy in sarcomas. Design, Setting, and Participants: This was an open-label, multicenter, phase 2 study of 4 cohorts of patients with advanced soft-tissue sarcoma (STS), including leiomyosarcoma (LMS), undifferentiated pleomorphic sarcoma (UPS), other sarcomas (others), and gastrointestinal stromal tumor (GIST)...
June 29, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28644098/intracranial-solitary-fibrous-tumors-hemangiopericytomas-first-report-of-malignant-progression
#20
Caroline Apra, Karima Mokhtari, Philippe Cornu, Matthieu Peyre, Michel Kalamarides
OBJECTIVE Meningeal solitary fibrous tumors/hemangiopericytomas (MSFTs/HPCs) are rare intracranial tumors resembling meningiomas. Their classification was redefined in 2016 by the World Health Organization (WHO) as benign Grade I fibrohyaline type, intermediate Grade II hypercellular type, and malignant highly mitotic Grade III. This grouping is based on common histological features and identification of a common NAB2-STAT6 fusion. METHODS The authors retrospectively identified 49 cases of MSFT/HPC. Clinical data were obtained from the medical records, and all cases were analyzed according to this new 2016 WHO grading classification in order to identify malignant transformations...
June 23, 2017: Journal of Neurosurgery
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