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Solitary Fibrous Tumor

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https://www.readbyqxmd.com/read/29028514/solitary-fibrous-tumor-in-the-abdomen-and-pelvis-a-case-series-with-radiological-findings-and-treatment-recommendations
#1
Adrian Fernandez, Miles Conrad, Ryan M Gill, Won-Tak Choi, Vishal Kumar, Spencer Behr
This study presents the radiological findings of seven cases of solitary fibrous tumor (SFT) in the abdomen and pelvis. A retrospective search of the pathology database at our institution was performed to identify cases of SFT in the abdomen and pelvis. After identifying seven cases, cross-sectional imaging was reviewed and characterized. We conclude that SFTs in the abdomen and pelvis should be considered with well-defined, circular, hypervascular masses. Pelvic SFTs should be considered with homogenous, avidly enhancing masses...
October 7, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29016372/the-peculiar-case-of-a-large-right-lower-quadrant-solitary-fibrous-tumor-with-vasculature-arising-from-the-splenic-artery-and-vein
#2
Andrew Jeremy Lukaszewicz, Harold Hayes, Mary Maunglay, Raman Muhar, Grygori Gerasymchuk, Shameem Menon
We present the interesting case of a patient with peritoneal solitary fibrous tumor (SFT). The patient initially presented with right lower quadrant pain. Computed tomography findings revealed the presence of a large mass near the cecum, with both arterial and venous blood supply arising directly from the splenic artery and vein. The patient ultimately underwent surgical excision of the mass, and pathological examination was consistent with benign SFT. Not only is the location of our patient's tumor exceedingly rare, but also, to our knowledge, it is the first reported case of SFT with such a unique vascular supply...
October 7, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28976138/leiomyosarcoma-of-maxilla-a-case-report-with-review-of-literature
#3
Renuka Gupta, Madhusudan Astekar, Ramakant Dandriyal, Manjunath Bs
One challenging feature of head and neck pathology is that a dizzying array of spindle cell lesions occurs here which ranges all the way from reactive, very aggressive forms to malignant lesions. Leiomyosarcoma is one such malignant tumour of mesenchymal origin exhibiting smooth muscle differentiation; presenting generally nonspecific signs and symptoms. Here we present a case of leiomyosarcoma in a 21 year old female patient associated with single reddish pink swelling present in the posterior right maxillary tuberosity region with moderate facial asymmetry...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28970578/intrathoracic-solitary-fibrous-tumor-an-international-multicenter-study-on-clinical-outcome-and-novel-circulating-biomarkers
#4
Bahil Ghanim, Sebastian Hess, Pietro Bertoglio, Ali Celik, Aynur Bas, Felicitas Oberndorfer, Franca Melfi, Alfredo Mussi, Walter Klepetko, Christine Pirker, Walter Berger, Imrich Harmati, Attila Farkas, Hendrik Jan Ankersmit, Balazs Dome, Janos Fillinger, Clemens Aigner, Balazs Hegedus, Ferenc Renyi-Vamos, György Lang
Intrathoracic solitary fibrous tumor (SFT) is a rare disease. Radical resection is the standard of care. However, estimating prognosis and planning follow-up and treatment strategies remains challenging. Data were retrospectively collected by five international centers to explore outcome and biomarkers for predicting event-free-survival (EFS). 125 histological proven SFT patients (74 female; 59.2%; 104 benign; 83.2%) were analyzed. The one-, three-, five- and ten-year EFS after curative-intent surgery was 98%, 90%, 77% and 67%, respectively...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28968297/solitary-fibrous-tumor-of-the-vulva-report-of-2-cases-including-a-de-novo-dedifferentiated-solitary-fibrous-tumor-diagnosed-after-molecular-demonstration-of-nab2-stat6-gene-fusion
#5
Juan C Tardío, Isidro Machado, Isabel Alemany, M Victoria López-Soto, M Gema Nieto, Antonio Llombart-Bosch
Solitary fibrous tumor (SFT) is a neoplasm of fibroblastic lineage that has been documented in almost every anatomic location. Vulval SFT is very rare with only 10 cases reported to date. We present 2 additional SFTs located in the vulva, in adult women of 59 and 25 yr of age. The first showed a classic morphology and immunophenotype with uniform and strong STAT6 nuclear expression. The other one was a spindle-cell de novo dedifferentiated SFT with heterogeneous nuclear and cytoplasmic STAT6 staining, which could only be correctly diagnosed after molecular analysis with demonstration of a NAB2-STAT6 gene fusion...
September 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28963025/cutaneous-solitary-fibrous-tumor-a-spindle-cell-neoplasm-with-distinctive-immunohistochemical-features
#6
J Santos-Juanes, B García-García, Y Hidalgo, B Vivanco
No abstract text is available yet for this article.
September 26, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28956313/a-case-of-a-wandering-mobile-solitary-fibrous-tumor-occurring-in-the-pancreas
#7
Shuhei Oana, Nozomi Matsuda, Sho Sibata, Kazuyuki Ishida, Tamotsu Sugai, Takayuki Matsumoto
A 73-year-old male with a complaint of abdominal discomfort was examined by abdominal ultrasonography and found to have a hypoechoic mass in the upper abdomen. On abdominal computed tomography (CT), there was a 5-cm, hypervascular mass between the stomach and aorta. Magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP) showed a homogeneous mass with hypointensity on T1-weighted images, accompanied by stenosis of the main pancreatic duct of the pancreatic head. On endoscopic ultrasonography, the mass was depicted as a round homogeneous, hypervascular mass attached to the pancreatic head...
September 27, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28948703/gastrointestinal-solitary-fibrous-tumor-from-lesser-omentum-an-elderly-from-malaysia-with-an-unusual-huge-painful-intra-abdominal-mass
#8
C S Ng, M Luqman, Z Q Wong, C S Ngiu, R A Raja Affendi
No abstract text is available yet for this article.
October 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28936155/intracranial-solitary-fibrous-tumor-hemangiopericytoma-report-of-two-cases-and-literature-review
#9
Hani Talal Aljohani, D Chaussemy, F Proust, S Chibbaro
Intracranial solitary fibrous tumors (ISFTs) are rare mesenchymal neoplasms originating in the meninges and constitute a heterogeneous group of rare spindle cell tumors that include benign and malignant neoplasms of which hemangiopericytoma is nowadays considered a cellular phenotypic variant. ISFT usually shows benign or indolent clinical behavior. We describe two cases of ISFT managed in our institution along with a review of pertinent literature.
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28932344/-a-pink-nodule-on-the-face
#10
Amina Kissou, Badredine Hassam
We report the case of a 32-year old female patient, with no notable medical history, requiring dermatology consultation for evaluation of a nodule on her right cheek which had evolved over the past 10 years. Clinical examination showed a reddish dermal-based nodule with a smooth surface. The lesion measured 1cm in diameter and was located at the level of the right cheek (A). There was no adenopathy and the remainder of the clinical examination was normal. The patient underwent skin biopsy which showed tumor proliferation composed of fusiform cells with poorly limited eosinophilic cytoplasm and lightly atypical elongated nuclei without mitosis and with mononuclear inflammatory cell infiltrate at the level of the dermis...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28914981/fna-cytology-of-solitary-fibrous-tumors-and-the-diagnostic-value-of-stat6-immunocytochemistry
#11
Edneia Tani, Johan Wejde, Kristina Åström, Inga-Lill Wingmo, Olle Larsson, Felix Haglund
BACKGROUND: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene. Recent studies have indicated that nuclear STAT6 immunohistochemistry is a specific marker for SFTs. METHODS: The authors reviewed fine-needle aspiration (FNA) specimens from extracranial SFTs diagnosed at their institution between 1993 and 2017...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28898989/role-of-histone-h3k27-trimethylation-loss-as-a-marker-for-malignant-peripheral-nerve-sheath-tumor-in-fine-needle-aspiration-and-small-biopsy-specimens
#12
Jeffrey K Mito, Xiaohua Qian, Leona A Doyle, Jason L Hornick, Vickie Y Jo
Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28894064/-establishment-of-preoperative-diagnosis-helpful-in-choosing-minimal-surgical-procedure-for-resecting-intrapulmonary-solitary-fibrous-tumor-report-of-a-case
#13
Natsumi Ohno, Eiji Yamada, Masahiko Muro
Intrapulmonary solitary fibrous tumor (SFT) arising from the parenchyma of the lung is very rare. Few limited surgery have been performed because preoperative and intraoperative diagnosises of SFT are so difficult. We here report a case of intrapulmonary SFT which was able to be resected by segmentectomy by preoperative diagnosis. A 77-year-old man, who was found to have an abnormal nodule in right lower lobe on computed tomography (CT), was admitted to our hospital. Fluorodeoxyglucose-positron emission tomography (PET) showed a slight uptake in the nodule...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28891048/identifying-actionable-variants-using-next-generation-sequencing-in-patients-with-a-historical-diagnosis-of-undifferentiated-pleomorphic-sarcoma
#14
Jeremy Lewin, Swati Garg, Beatrice Y Lau, Brendan C Dickson, Frank Traub, Nalan Gokgoz, Anthony M Griffin, Peter C Ferguson, Irene L Andrulis, Hao-Wen Sim, Suzanne Kamel-Reid, Tracy L Stockley, Lillian Siu, Jay S Wunder, Albiruni Ra Razak
There are limited data regarding the molecular characterization of undifferentiated pleomorphic sarcomas (UPS; formerly malignant fibrous histiocytoma). This study aimed to investigate the utility of next generation sequencing (NGS) in UPS to identify subsets of patients who harbour actionable mutations. Patients diagnosed with UPS underwent pathological re-evaluation by a pathologist specializing in sarcoma. Tumor DNA was isolated from archived fresh frozen tissue samples and genotyped using NGS with the Illumina MiSeq TruSeq Amplicon Cancer Panel (48 genes, 212 amplicons)...
September 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28887603/molecular-signature-of-tumors-with-monoallelic-13q14-deletion-a-case-series-of-spindle-cell-lipoma-and-genetically-related-tumors-demonstrating-a-link-between-foxo1-status-and-p38-mapk-pathway
#15
Karina Uehara, Fukino Ikehara, Ryo Shibuya, Iwao Nakazato, Mariko Oshiro, Masaya Kiyuna, Yasuka Tanabe, Zensei Toyoda, Kiyoto Kurima, Shinichiro Kina, Masanori Hisaoka, Takao Kinjo
Spindle cell/pleomorphic lipomas (SCLs), cellular angiofibromas (CAFs) and mammary-type myofibroblastomas (MFBs) are rare benign mesenchymal tumors with monoallelic 13q14 deletion. They are predicted to have a common pathogenic mechanism due to shared similar histological and immunohistochemical features; however, pathological consequences of monoallelic 13q14 deletion remain unknown. We previously reported a CAF case with monoallelic 13q14 deletion in which the tumor expressed decreased levels of FOXO1 and RB1, both of which were encoded in 13q14, and increased reactive oxygen species (ROS) levels...
September 8, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28883708/rarity-among-benign-gastric-tumors-plexiform-fibromyxoma-report-of-two-cases
#16
Kinga Szurian, Holger Till, Eva Amerstorfer, Nicole Hinteregger, Hans-Jörg Mischinger, Bernadette Liegl-Atzwanger, Iva Brcic
Plexiform fibromyxoma is a very rare mesenchymal tumor of the stomach, found almost exclusively in the antrum/pylorus region. The most common presenting symptoms are anemia, hematemesis, nausea and unintentional weight loss, without sex or age predilection. We describe here two cases of plexiform fibromyxoma, involving a 16-year-old female and a 34-year-old male. Both patients underwent complete resection (R0) by distal gastrectomy and retrocolic gastrojejunostomy (according to Billroth 2); for both, the postoperative course was uneventful...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28877837/clinical-diagnosis-and-treatment-of-male-breast-cancer-analysis-of-24-cases
#17
Yu-Qian Zhang, Hai-Yan Zhao, Qiang Sun, Feng Mao, Yi-Dong Zhou, Jing-Min Zhou
Objective To summarize our experiences in the clinical diagnosis and treatment of male breast cancer(MBC).Methods The clinical date of 24 MBC patients treated in our hospital from January 2006 to December 2012 were retrospective analyzed.Results The average age of these 24 patients was(55.7±2.1) years.All the patients received surgical treatment,and the surgical procedures were simple excision of breast lesion in 6 patients,breast resection alone in 5 patients,and modified radical mastectomy in 13 patients(bilateral in 1 case)...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28877376/solitary-fibrous-tumor-of-the-breast-a-rare-neoplasm
#18
Juana Brenes, Arancha Moreno, M Jesús Merchán, Myriam Montes, M José Ciudad, Cristina Riola, M Eugenia Olivares, José A Cortés, M Ángeles Cuadrado, José M Román
No abstract text is available yet for this article.
September 6, 2017: Breast Journal
https://www.readbyqxmd.com/read/28877060/clinicopathologic-diversity-of-undifferentiated-sarcoma-with-bcor-ccnb3-fusion-analysis-of-11-cases-with-a-reappraisal-of-the-utility-of-immunohistochemistry-for-bcor-and-ccnb3
#19
Atsuji Matsuyama, Eisuke Shiba, Yoshihisa Umekita, Kanae Nosaka, Takihiro Kamio, Hiroyuki Yanai, Chika Miyasaka, Reiko Watanabe, Ichiro Ito, Tomoko Tamaki, Shinichi Hayashi, Masanori Hisaoka
Undifferentiated sarcoma harboring the BCOR-CCNB3 fusion is characterized by its predilection to affect skeletons of adolescent males, cellular small round/spindle cell morphology, and CCNB3 immunoreactivity. We analyzed 11 cases of BCOR-CCNB3 sarcoma, 10 of which were identified in a reverse transcription-polymerase chain reaction-based screen of 85 patient samples recorded in our database as unclassified small round or spindle cell sarcomas. BCOR rearrangements were confirmed by fluorescence in situ hybridization in 8 tumors...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877055/solitary-fibrous-tumors-of-the-head-and-neck-a-multi-institutional-clinicopathologic-study
#20
Steven C Smith, William E Gooding, Matthew Elkins, Rajiv M Patel, Paul W Harms, Andrew S McDaniel, Nallasivam Palanisamy, Cora Uram-Tuculescu, Bonnie B Balzer, David R Lucas, Raja R Seethala, Jonathan B McHugh
Solitary fibrous tumors (SFTs) of the head and neck are uncommon. Lesions previously diagnosed in the head and neck as hemangiopericytomas (HPCs), giant cell angiofibromas (GCAs), and orbital fibrous histiocytomas (OFHs) are now recognized as within the expanded spectrum of SFTs. To better understand the clinicopathologic profile of head and neck SFTs, we performed a multi-institutional study of 88 examples. There was no sex predilection (F:M ratio 1.2), and the median patient age was 52 years (range: 15 to above 89 y)...
September 4, 2017: American Journal of Surgical Pathology
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