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https://www.readbyqxmd.com/read/28430185/phospholipase-c%C3%AE-1-regulates-p38-mapk-activity-and-skin-barrier-integrity
#1
Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami
Keratinocytes undergo a unique type of programmed cell death known as cornification, which leads to the formation of the stratum corneum (SC), the main physical barrier of the epidermis. A defective epidermal barrier is a hallmark of the two most common inflammatory skin disorders, psoriasis, and atopic dermatitis. However, the detailed molecular mechanisms of skin barrier formation are not yet fully understood. Here, we showed that downregulation of phospholipase C (PLC) δ1, a Ca(2+)-mobilizing and phosphoinositide-metabolizing enzyme abundantly expressed in the epidermis, impairs the barrier functions of the SC...
April 21, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28425260/the-efficacy-of-microphototherapy-with-a-medlight-cupcubegrimed-device-in-psoriatic-patients-with-localized-lesions
#2
Neslihan Yildirim, Gül Erkin
BACKGROUND/AIM: Psoriasis is a chronic skin disease. To reduce side effects associated with current treatment modalities, new treatment methods are required. Some clinicians have begun to use microphototherapy to treat psoriatic patients with a limited number of lesions (lesions affecting <10% of the body surface area). MATERIALS AND METHODS: Microphototherapy is indicated in patients whose lesions persist despite systemic and topical treatment or when such treatment is contraindicated...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425249/prediction-of-atopy-via-total-immunoglobulin-e-levels-andskin-prick-tests-in-patients-with-psoriasis
#3
Emine Sümeyye Ünal, Ülker Gül, Adile Berna Dursun, Ferda Öner Erkekol
BACKGROUND/AIM: Although the etiopathogeneses of psoriasis and atopy appear to be different, psoriasis has been found to be associated with atopy and atopic dermatitis. In this study, we aimed to determine the role of atopy by examining the medical history and clinical and laboratory findings of patients with psoriasis. MATERIALS AND METHODS: Patients with psoriasis, asthma patients, and healthy volunteers were included in the study. Serum total immunoglobulin E (IgE) levels were obtained, and prick tests were administered to all groups...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425242/evaluation-of-serum-uric-acid-levels-in-psoriasis-vulgaris
#4
Emrah Yilmaz, Emine Tamer, Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk
BACKGROUND/AIM: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425237/the-efficacy-of-narrowband-uvb-treatment-in-pediatricvitiligo-a-retrospective-analysis-of-26-cases
#5
Serkan Yazici, Berrin Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali
BACKGROUND/AIM: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively. MATERIALS AND METHODS: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28422002/treatment-of-psoriasis-with-ustekinumab-improved-skin-tightening-in-systemic-sclerosis
#6
Asako Ichihara, Masatoshi Jinnin, Hironobu Ihn
Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by fibrosis, inflammation and vasculopathy in the skin and internal organs. Recently, several articles described that Th17 cells, IL-23 and IL-17 levels were significantly elevated in the peripheral blood or fibrotic sites of SSc. We report a case of SSc and psoriasis administered ustekinumab, IL-12/IL-23 inhibitor. In this case, the skin tightening was successfully improved and ustekinumab was more effective, even though oral prednisolone (9-12 mg/day) had some effect on skin tightening and arthralgia...
April 19, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28421729/effects-of-tnf-%C3%AE-inhibitors-in-patients-with-psoriasis-and-metabolic-syndrome-a-preliminary-study
#7
Giulia Merlo, Emanuele Cozzani, Martina Burlando, Stefano Calvieri, Concetta Potenza, Luca Stingeni, Giorgio Filosa, Monica Pau, Marco Simonacci, Marzia Caproni, Aurora Parodi
BACKGROUND: Psoriasis is an inflammatory disease, that is increasingly being considered as a systemic disorder. Among associated comorbidities, metabolic syndrome plays an important role. The effects of biological therapies on metabolic syndrome is controversial. METHODS: Thirty-one psoriatic patients with metabolic syndrome, eligible to treatment with anti-TNFα agents, were enrolled. Metabolic parameters were measured during 4 subsequent visits, one every 40 to 60 days...
April 19, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28421233/psoriasis-and-pro-angiogenetic-factor-cd93-gene-expression-and-association-with-gene-polymorphism-suggests-a-role-in-disease-pathogenesis
#8
Albert Duvetorp, Renate Slind Olsen, Marita Skarstedt, Jan Söderman, Oliver Seifert
CD93 is involved in angiogenesis and inflammation, both of which are key processes in the pathogenesis of psoriasis. CD93 was studied in serum, peripheral blood mononuclear cells and skin of patients with psoriasis and controls. Furthermore, allele frequencies for CD93 single-nucleotide polymorphisms rs2749812 and rs2749817 were assessed in patients with psoriasis compared with controls and the effect of narrowband ultraviolet B (NB-UVB) treatment on CD93 gene expression was evaluated in the skin of patients with psoriasis...
April 19, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28420676/the-association-between-etanercept-serum-concentration-and-psoriasis-severity-is-highly-age-dependent
#9
Iris Detrez, Kristel Van Steen, Siegfried Segaert, Ann Gils
The association between etanercept serum concentration and psoriasis disease severity is poorly investigated and currently etanercept serum concentration monitoring aiming to optimize psoriasis treatment lacks evidence. In this prospective study, we investigated the relation between etanercept exposure and disease severity via measuring etanercept concentrations at five consecutive time points in 56 psoriasis patients. Disease severity assessments included the Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA) and Physician Global Assessment (PGA), and etanercept and anti-etanercept antibody concentrations were determined every three months for a period of one year...
April 18, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28420295/optimization-of-methotrexate-loaded-niosomes-by-box-behnken-design-an-understanding-of-solvent-effect-and-formulation-variability
#10
Ahmed S Zidan, Mahmoud Mokhtar Ibrahim, Nagia A El Megrab
Dermal drug delivery system which localizes methotrexate (MTX) in the skin is advantageous in topical treatment of psoriasis. The aim of the current study was to understand dilution effects and formulation variability for the potential formation of niosomes from proniosome gels of MTX. Box-Behenken design was employed to prepare a series of MTX proniosome gels of Span 40, cholesterol (Chol-X1) and Tween 20 (T20-X2). Short chain alcohols (X3), namely ethanol (Et), propylene glycol (Pg) and glycerol (G) were evaluated for their dilution effects on proniosomes...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28419647/a-dramatic-response-to-a-single-dose-of-infliximab-in-a-patient-with-prolonged-pustular-psoriasis-derived-from-inverse-psoriasis
#11
Mengmeng Li, Weiwei Dai, Wei Yan, Yuanzhen Liu, Lian Wang, Wei Li
We report a case of a 25-year-old Chinese man with an exceptionally prolonged history of pustular psoriasis derived from inverse psoriasis who was unsatisfied with conventional treatment and was successfully treated with a single dose of infliximab without noticeable adverse effects. No recurrence or flaring was observed after 3 months of follow-up. This case illustrates that infliximab may be an effective and safe therapeutic option for patients with refractory pustular psoriasis derived from inverse psoriasis...
April 17, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28419600/reformulations-of-well-known-active-ingredients-in-the-topical-treatment-of-psoriasis-vulgaris-can-improve-clinical-outcomes-for-patients
#12
REVIEW
L Iversen, E Dauden, S Segaert, K Freeman, S Magina, D Rigopoulos, D Thaci
BACKGROUND: Although the majority of patients with psoriasis vulgaris are treated exclusively with topical therapies, research to develop more effective topical therapies that are associated with higher patient satisfaction has lagged behind the development of systemic agents. OBJECTIVE: The aim of this literature review was to determine whether there is documented evidence that applying an innovative approach to improving the formulation of active ingredients commonly used in the topical treatment of psoriasis can have a positive effect on clinical outcomes and patient-reported outcomes (PROs)...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28418602/expression-of-low-density-lipoprotein-related-receptors-5-and-6-lrp5-6-in-psoriasis-skin
#13
Albert Duvetorp, Renate Slind Olsen, Helena Nyström, Marita Skarstedt, Olaf Dienus, Ulrich Mrowietz, Jan Söderman, Oliver Seifert
Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are transmembrane receptors with key functions in canonical Wnt signaling. Wnt ligands are thought to play an important role in innate immunity and psoriasis and recent studies assigned LRP5/6 anti-inflammatory properties. The objective of this study was to investigate the expression of LRP5 and LRP6 in lesional and non-lesional skin in peripheral blood and in mononuclear cells of patients with chronic plaque type psoriasis compared with control individuals...
April 18, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28414177/the-acitretin-and-methotrexate-combination-therapy-for-psoriasis-vulgaris-achieves-higher-effectiveness-and-less-liver-fibrosis
#14
Jingang An, Dingwei Zhang, Jiawen Wu, Jiong Li, Xiu Teng, Xiaomin Gao, Ruilian Li, Xiuying Wang, Linlin Xia, Yumin Xia
Both acitretin and methotrexate are effective in ameliorating psoriatic lesion. However, their combination has been seldom reported in the treatment of psoriasis because of the warning regarding the potential hepatotoxicity of the drug interactions. This study was designed to investigate the effectiveness of such combination therapy for psoriasis vulgaris, and the potential benefit as well as side effect during the treatment. Thirty-nine patients with psoriasis vulgaris were treated with acitretin, methotrexate or their combination or as control...
April 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28413099/second-line-biologic-therapy-optimization-in-rheumatoid-arthritis-psoriatic-arthritis-and-ankylosing-spondylitis
#15
REVIEW
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Ennio Giulio Favalli, Andrea Becciolini, Maurizio Benucci, Francesca Li Gobbi, Serena Guiducci, Rosario Foti, Marta Mosca, Delia Goletti
OBJECTIVE: The Italian board for the TAilored BIOlogic therapy (ITABIO) reviewed the most consistent literature to indicate the best strategy for the second-line biologic choice in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). METHODS: Systematic review of the literature to identify English-language articles on efficacy of second-line biologic choice in RA, PsA, and ankylosing spondylitis (AS). Data were extracted from available randomized, controlled trials, national biologic registries, national healthcare databases, post-marketing surveys, and open-label observational studies...
March 22, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28412046/the-epigenetic-mechanism-for-discordance-of-autoimmunity-in-monozygotic-twins
#16
REVIEW
Zhongyuan Xiang, Yuanqing Yang, Christopher Chang, Qianjin Lu
Monozygotic twins share an identical DNA sequence but are not truly "identical". In fact, when it comes to health and disease, they may often display some level of phenotypic discordance. The cause of this discordance is often unknown. Epigenetic modifications such as DNA methylation, histone modification, and microRNAs-mediated regulation regulate gene expression and are sensitive to external stimuli. These modifications may be seen to bridge the gap between genetics and the environment. Over the years, the importance of epigenetics as a primary mechanism for the role that the environment plays in defining phenotype has been increasingly appreciated...
April 12, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28407625/comparison-of-occlusive-and-open-application-in-a-psoriasis-plaque-test-design-examplarily-using-investigations-of-mapracorat-0-1-ointment-versus-vehicle-and-reference-drugs
#17
Walter Wigger-Alberti, Ragna Williams, Yi-Ling von Mackensen, Maciej Hoffman-Wecker, Ulrike Grossmann, Gerald Staedtler, Richard Nkulikiyinka, Kaweh Shakery
BACKGROUND/AIMS: Psoriasis plaque tests (PPTs) are important tools in the early phases of antipsoriatic drug development. Two distinct PPT design variants (open vs. occluded drug application) are commonly used, but no previous work has aimed to directly compare and contrast their performance. METHODS: We compared the antipsoriatic efficacy of mapracorat 0.1% ointment and reference drugs reported in 2 separate studies, representing open and occluded PPT designs. The drug effect size was measured by sonography (mean change in echo-poor band thickness), chromametry, and standardized clinical assessment...
April 14, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28406531/economic-burden-of-psoriatic-patients-in-japan-analysis-from-a-single-outpatient-clinic
#18
Hidetoshi Takahashi, Katsuhiko Satoh, Akiyoshi Takagi, Hajime Iizuka
Topical and systemic agents have dramatically improved the treatment efficacy of psoriasis. Few reports, however, exist describing the economic burden in Japanese psoriatic patients. The aim of the study was to evaluate the total costs as well as cost versus efficacy of topical and systemic treatments of psoriatic patients under the Japanese health insurance system. The retrospective study was performed from the database of our clinic, which is located in Hokkaido Prefecture. Cost and effectiveness of psoriatic patients were evaluated during the 12-month period from April 2015 to March 2016...
April 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28406130/is-the-periodontal-status-a-risk-factor-for-the-development-of-psoriasis
#19
G Sarac, Y Kapicioglu, S Cayli, A Altas, S Yologlu
BACKGROUND AND OBJECTIVES: Psoriasis is a common, chronic, inflammatory, and hyperproliperative skin disease. It has been known that the infectious agents play a role in triggering and exacerbation of the disease. Periodontal diseases are chronic inflammatory gum diseases initiated by microorganisms in dental plaques. This study intended to determine the role of periodontal diseases, as chronic infective foci in psoriasis. MATERIALS AND METHODS: A total of 76 patients, who applied to Faculty of Medicine, Department of Dermatology, İnönü University, diagnosed as psoriasis and a control group consisting of 76 dermatologic patients without any systemic disease at similar age and gender were included the study...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28405739/dermatological-comorbidity-in-psoriasis-results-from-a-large-scale-cohort-of-employees
#20
N Zander, I Schäfer, M Radtke, A Jacobi, H Heigel, M Augustin
The field of dermatological comorbidity in psoriasis is only passively explored with contradictory results. Objective of this study was to further investigate the complex field of psoriasis and associated skin diseases by identifying skin comorbidity patterns in an extensive cohort of employees in Germany. Retrospective analysis of data deriving from occupational skin cancer screenings was conducted. From 2001 to 2014 German employees between 16 and 70 years from different branches underwent single whole-body screenings by trained dermatologists in their companies...
April 12, 2017: Archives of Dermatological Research
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