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https://www.readbyqxmd.com/read/28226326/psoriasis-and-obesity
#1
Peter Jensen, Lone Skov
Psoriasis is a common chronic inflammatory skin disease with a complex pathogenesis consisting of a genetic component, immune dysfunction, and environmental factors. It is associated with numerous comorbidities including psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Evidence suggests that obesity is a risk factor for incident psoriasis, aggravates existing psoriasis, and that weight reduction may improve the severity of psoriasis in overweight individuals. Excess body weight may interfere with the medical treatment used in psoriasis and adds to the cardiovascular risk profile in these patients, which underscores the importance of effective weight control regimens...
February 23, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28225956/prevalence-of-metabolic-syndrome-in-patients-with-psoriasis-a-hospital-based-cross-sectional-study
#2
Danijela Milčić, Slavenka Janković, Sonja Vesić, Mirjana Milinković, Jelena Marinković, Andja Ćirković, Janko Janković
BACKGROUND: Emerging epidemiological evidence suggests independent associations between psoriasis and metabolic syndrome. Objectives: The aim of the study was to examine the prevalence of metabolic syndrome and its components in patients with psoriasis, and to assess which factors may predict metabolic syndrome in these patients. METHODS: A hospital-based, cross-sectional study with 244 psoriatic patients and 163 control subjects with skin diseases other than psoriasis was conducted at the Clinic of Dermatovenerology, Clinical Center of Serbia, Belgrade, from October 2011 to October 2012...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28225200/alcohol-dependence-and-risk-of-somatic-diseases-and-mortality-a-cohort-study-in-19-002-men-and-women-attending-alcohol-treatment
#3
Charlotte Holst, Janne Schurmann Tolstrup, Holger Jelling Sørensen, Ulrik Becker
AIMS: To (1) estimate sex-specific risks of a comprehensive spectrum of somatic diseases in alcohol dependent individuals versus a control population, and in the same population to (2) estimate sex-specific risks of dying from the examined somatic diseases. DESIGN: Register-based matched cohort study. Alcohol dependent individuals were identified from an alcohol treatment database. Controls were randomly selected from the Danish Civil Registration System. Information on somatic diseases obtained from the Danish National Patient Registry and causes of death obtained from the Cause of Death Registry...
February 22, 2017: Addiction
https://www.readbyqxmd.com/read/28224166/routine-laboratory-parameter-dynamics-and-laboratory-adverse-events-in-psoriasis-patients-on-long-term-treatment-with-adalimumab-etanercept-and-ustekinumab
#4
Jochen H Hoffmann, Christian Knoop, Alexander H Enk, Eva N Hadaschik
Only limited data on laboratory parameter dynamics and safety under prolonged biologic treatment in a "real-world" scenario are available for recommendations on screening and monitoring. This study is a retrospective analysis of routine parameter dynamics and laboratory adverse events (LAE) in psoriasis patients on long-term treatment (n = 199) with tumour necrosis factor (TNF)-α-antagonists (adalimumab, etanercept), and the interleukin (IL)12/23-antagonist ustekinumab. Overall, neutrophil (PMN) counts (-11%) and triglycerides (+9%) changed considerably...
February 22, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28223747/the-advantage-of-cyclosporine-a-and-methotrexate-rotational-therapy-in-long-term-systemic-treatment-for-chronic-plaque-psoriasis-in-a-real-world-practice
#5
Chong Won Choi, Bo Ri Kim, Jungyoon Ohn, Sang Woong Youn
BACKGROUND: Psoriasis is a chronic inflammatory disease. In the treatment of psoriasis, cyclosporine is commonly prescribed systemic agents. However, long-term use of cyclosporine is not recommended because of side effects such as nephrotoxicity or hypertension. OBJECTIVE: To ascertain the improved safety of rotational therapy using cyclosporine and methotrexate, we investigated the frequency of abnormal results in laboratory test after long term rotational therapy using cyclosporine and methotrexate...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28222745/psoriasis-and-associated-variables-in-classification-and-outcome-of-juvenile-idiopathic-arthritis-an-eight-year-follow-up-study
#6
Maria Ekelund, Kristiina Aalto, Anders Fasth, Troels Herlin, Susan Nielsen, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Marek Zak, Lillemor Berntson
BACKGROUND: To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA). METHODS: In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these children. The presence of psoriasis, psoriasis-like rash, dactylitis, nail pitting, enthesitis, tenosynovitis and heredity was assessed in relation to ILAR classification and remission...
February 22, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28222230/evaluation-of-adherence-predictors-for-the-treatment-of-moderate-to-severe-psoriasis-with-biologics-the-importance-of-physician-patient-interaction-and-communication
#7
I Zschocke, C Ortland, K Reich
BACKGROUND: Treatment efficacy of biologic agents in moderate to severe psoriasis is regarded as high with patient adherence being higher than for traditional therapies. However, use of biologics is connected to high discontinuation rates. The current investigator-initiated study was conducted to improve the understanding of adherence. MATERIALS AND METHODS: The study was designed as non-interventional retrospective multicentre trial in Germany. Questionnaires were developed based on the adherence dimensions identified by the World Health Organisation, WHO...
February 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28220603/phosphor-for-phototherapy-review-on-psoriasis
#8
REVIEW
P S Hemne, R G Kunghatkar, S J Dhoble, S V Moharil, V Singh
We review developments in the field of phototherapy in terms of the treatment wavelength, dosimetry and phosphor used for different dermatoses. We attempt to categorize skin lesions and diseases by morphology, focusing on conditions that can be treated using phototherapy and photochemotherapy. Recent research and review articles are studied, the treatments explained and information on phototherapy that is applicable to psoriasis and other diseases is tabulated. The clinical features, epidemiology, epitalogy and various types of psoriasis, together with the therapies available to treat them are reported...
February 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28217649/effects-of-the-schema-therapy-and-mindfulness-on-the-maladaptive-schemas-hold-by-the-psoriasis-patients-with-the-psychopathology-symptoms
#9
Parvin Jamali Gojani, Mohsen Masjedi, Shahnaz Khaleghipour, Ehsan Behzadi
BACKGROUND: This study aimed to compare the effects of the schema along with mindfulness-based therapies in the psoriasis patients. MATERIALS AND METHODS: This semi-experimental study with post- and pre-tests was conducted on the psoriasis patients in the Dermatology Clinic of the Isfahan Alzahra Hospital, Iran using the convenience sampling in 2014. The patients had a low general health score. The experimental groups included two treatment groups of schema-based (n = 8) and mindfulness (n = 8)...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28217466/secukinumab-efficacy-and-safety-in-indian-patients-with-moderate-to-severe-plaque-psoriasis-sub-analysis-from-fixture-a-randomized-placebo-controlled-phase-3-study
#10
Ramesh M Bhat, B Leelavathy, Sacchidanand S Aradhya, Maragondanahalli G Gopal, D V S Pratap, Mir Mubashir, Putta Srinivas, Sushil Y Pande, Amit S Thavkar
TITLE: Secukinumab efficacy and safety in Indian patients with moderate-to-severe plaque psoriasis: sub-analysis from FIXTURE (Full Year Investigative Examination of Secukinumab vs. Etanercept Using Two Dosing Regimens to Determine Efficacy in Psoriasis), a randomized, placebo-controlled, phase 3 study. BACKGROUND: Evidence has suggested Interleukin (IL)-17A to be an important effector cytokine in the pathogenesis of psoriasis. Here, we report results for an Indian sub-population from a multinational study FIXTURE, designed to assess the safety, tolerability, and long-term efficacy of fully human anti-IL-17A monoclonal antibody secukinumab in patients with moderate-to-severe plaque psoriasis...
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28217129/ultraviolet-b-inhibits-il-17a-tnf-%C3%AE-stimulated-activation-of-human-dermal-fibroblasts-by-decreasing-the-expression-of-il-17ra-and-il-17rc-on-fibroblasts
#11
Li Yin, YingYing Hu, JiaLi Xu, Jing Guo, Jie Tu, ZhiQiang Yin
BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory disease, and a mixed Th1/Th17 cytokine environment plays a critical role in the pathogenesis of psoriasis. Dermal fibroblasts secrete certain cytokines such as IL-6, IL-8, and CXCL-1, contributing to the hyperproliferative state of the epidermis in psoriatic skin. Ultraviolet B (UVB) phototherapy is one of the most commonly used treatments in psoriasis but the influence of UVB on human dermal fibroblasts (HDFs) in psoriasis treatment is not completely understood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28214371/the-risk-of-depression-suicidal-ideation-and-suicide-attempt-in-patients-with-psoriasis-psoriatic-arthritis-or-ankylosing-spondylitis
#12
J J Wu, R B Penfold, P Primatesta, T K Fox, C Stewart, S P Reddy, A Egeberg, J Liu, G Simon
BACKGROUND: Sparse information is available concerning mental health issues in psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients. OBJECTIVE: To estimate risk of depression, suicidal ideation, and suicide attempt in patients with psoriasis, PsA, and AS, respectively, compared with the general population. METHODS: This population-based cohort study analyzed 36,214 psoriasis patients, 5,138 PsA patients, and 1,878 AS patients who were frequency-matched with a general population cohort...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28214326/treatment-preferences-for-biologicals-in-psoriasis-experienced-patients-appreciate-sustainability
#13
Christian Kromer, Wiebke K Peitsch, Raphael Herr, Astrid Schmieder, Diana Sonntag, Marthe-Lisa Schaarschmidt
BACKGROUND AND OBJECTIVES: Treatment satisfaction can be improved by integrating patients' preferences into shared decision-making. We recently investigated patients' preferences for attributes of biologicals, and showed high preferences for safety and efficacy. The objective of the present study was to assess the impact of treatment experience on these preferences. PATIENTS AND METHODS: Preferences for outcome (probability of 50 % and 90 % improvement, time until response, sustainability of success, probability of mild and severe adverse events, probability of ACR 20 response) and process attributes (treatment location, frequency, duration, and delivery method) were analyzed in 200 participants with moderate-to-severe psoriasis using conjoint analysis...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28214304/efficacy-and-safety-of-fumaric-acid-esters-in-combination-with-phototherapy-in-patients-with-moderate-to-severe-plaque-psoriasis-fast
#14
Peter Weisenseel, Kristian Reich, Wiebke Griemberg, Katharina Merten, Christine Gröschel, Natalie Nunez Gomez, Kirsi Taipale, Beate Bräu, Ina Zschocke
BACKGROUND: While treatment of patients with moderate-to-severe psoriasis using a combination of fumaric acid esters (FAE, Fumaderm(®) ) and phototherapy (UV) is common practice, there have been hardly any studies investigating this regimen. Available information is limited to data from a small pilot study. The objective of the present study was to evaluate FAE/UV combination therapy in a larger patient cohort with moderate-to-severe psoriasis. PATIENTS AND METHODS: In this prospective noninterventional multicenter study, data from patients treated with FAE/UV combination therapy was assessed with regard to efficacy (PGA' PASI, DLQI, EQ-5D), safety, and dosage over a twelve-month period...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28213862/apremilast-a-review-in-psoriasis-and-psoriatic-arthritis
#15
Gillian M Keating
Apremilast (Otezla(®)) is an orally administered, small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast 30 mg twice daily reduced the severity of moderate to severe plaque psoriasis in the phase 3 ESTEEM trials, as well as improving difficult-to-treat nail, scalp and palmoplantar psoriasis. Most patient-reported outcomes, including pruritus and the total Dermatology Life Quality Index, also improved to a significantly greater extent with apremilast than with placebo, with significant improvements in pruritus and skin discomfort/pain visual analogue scale scores seen as early as week 2 with apremilast...
February 18, 2017: Drugs
https://www.readbyqxmd.com/read/28212864/gpr43-activation-enhances-psoriasis-like-inflammation-through-epidermal-upregulation-of-il-6-and-dual-oxidase-2-signaling-in-a-murine-model
#16
Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Ahmed M El-Sherbeeny, Mohammed M Al-Harbi, Talal S Almukhlafi
The gut is densely inhabited by commensal bacteria, which metabolize dietary fibers/undigested carbohydrates and produce short-chain fatty acids such as acetate. GPR43 is one of the receptors to sense short-chain fatty acids, and expressed in various immune and non-immune cells. Acetate/GPR43 signaling has been shown to affect various inflammatory diseases through Th17 responses and NADPH oxidase (NOX)-derived reactive oxygen species (ROS) generation. However, no study has previously explored the effects of GPR43 activation during psoriasis-like inflammation...
February 14, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28209630/inhibition-of-phosphodiesterase-4-pde4-reduces-dermal-fibrosis-by-interfering-with-the-release-of-interleukin-6-from-m2-macrophages
#17
Christiane Maier, Andreas Ramming, Christina Bergmann, Rita Weinkam, Nicolai Kittan, Georg Schett, Jörg H W Distler, Christian Beyer
OBJECTIVES: To investigate the disease-modifying effects of phosphodiesterase 4 (PDE4) inhibition in preclinical models of systemic sclerosis (SSc). METHODS: We studied the effects of PDE4 inhibition in a prevention and a treatment model of bleomycin-induced skin fibrosis, in the topoisomerase mouse model as well as in a model of sclerodermatous chronic graft-versus-host disease. To better understand the mode of action of PDE4 blockade in preclinical models of SSc, we investigated fibrosis-relevant mediators in fibroblasts and macrophages from healthy individuals and patients suffering from diffuse-cutaneous SSc on blockade of PDE4...
February 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28207934/role-of-hla-c-06-in-clinical-response-to-ustekinumab-evidence-from-real-life-in-a-large-cohort-of-european-patients
#18
M Talamonti, M Galluzzo, J M van den Reek, E M de Jong, J L W Lambert, P Malagoli, L Bianchi, A Costanzo
BACKGROUND: Little is known about role of HLA-C*06 related to response to psoriasis treatments. OBJECTIVES: This study that involved four European centres aims to confirm the role of HLA-C*06 in a new large cohort of patients, as a pharmacogenetic marker of response to ustekinumab. METHODS: In this retrospective multicenter study we reviewed data of 255 psoriasis patients genotyped for HLA-C*06, which have started ustekinumab treatment between January 2014 and March 2015...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28201942/correction-to-early-clinical-response-to-tofacitinib-treatment-as-a-predictor-of-subsequent-efficacy-results-from-two-phase-3-studies-of-patients-with-moderate-to-severe-plaque-psoriasis
#19
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28197901/safety-and-efficacy-of-brodalumab-for-moderate-to-severe-plaque-psoriasis-a-systematic-review-and-meta-analysis
#20
REVIEW
Attia Attia, Abdelrahman Ibrahim Abushouk, Hussien Ahmed, Mohamed Gadelkarim, Ahmed Elgebaly, Zeinab Hassan, Mohamed M Abdel-Daim, Ahmed Negida
BACKGROUND: Psoriasis is an inflammatory skin disease that affects 2-3% of the worldwide population. The interleukin-17 cytokine family has been proven to play a central role in the pathogenesis of psoriasis. Brodalumab is a novel biologic agent that targets interleukin-17 molecules and their receptors. We aimed to evaluate the safety and efficacy of brodalumab as a therapeutic agent for moderate-to-severe psoriasis in a meta-analysis framework. METHODS: A computer literature search of PubMed, OVID, Cochrane Central, EMBASE, EBSCO, Scopus, and Web of Science was conducted using relevant keywords...
February 14, 2017: Clinical Drug Investigation
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