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albumin sepsis shock

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https://www.readbyqxmd.com/read/27864924/pentraxin-3-in-patients-with-severe-sepsis-or-shock-the-albios-trial
#1
Pietro Caironi, Serge Masson, Tommaso Mauri, Barbara Bottazzi, Roberto Leone, Michela Magnoli, Simona Barlera, Filippo Mamprin, Andrea Fedele, Alberto Mantovani, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Roberto Latini
BACKGROUND: The long pentraxin PTX3 is a key component of the humoral arm of innate immunity related to sepsis severity and mortality. We evaluated the clinical and prognostic significance of circulating PTX3 in the largest cohort ever reported of patients with severe sepsis or septic shock. DESIGN: Plasma PTX3 was measured on days 1, 2 and 7 after randomization of 958 patients to albumin or crystalloids for fluid resuscitation in the multicenter Albumin Italian Outcome Sepsis (ALBIOS) trial...
November 16, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27593863/hypoalbuminemia-low-base-excess-values-and-tachypnea-predict-28-day-mortality-in-severe-sepsis-and-septic-shock-patients-in-the-emergency-department
#2
Min Ho Seo, Minhong Choa, Je Sung You, Hye Sun Lee, Jung Hwa Hong, Yoo Seok Park, Sung Phil Chung, Incheol Park
PURPOSE: The objective of this study was to develop a new nomogram that can predict 28-day mortality in severe sepsis and/or septic shock patients using a combination of several biomarkers that are inexpensive and readily available in most emergency departments, with and without scoring systems. MATERIALS AND METHODS: We enrolled 561 patients who were admitted to an emergency department (ED) and received early goal-directed therapy for severe sepsis or septic shock...
November 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27503783/characterization-of-perioperative-infection-risk-among-patients-undergoing-radical-cystectomy-results-from-the-national-surgical-quality-improvement-program
#3
William P Parker, Matthew K Tollefson, Courtney N Heins, Kristine T Hanson, Elizabeth B Habermann, Harras B Zaid, Igor Frank, R Houston Thompson, Stephen A Boorjian
OBJECTIVES: To evaluate the incidence, risk factors, and timing of infections following radical cystectomy (RC). METHODS: The American College of Surgeons National Surgical Quality Improvement Project database was queried to identify patients undergoing RC for bladder cancer from 2006 to 2013. Characteristics including year of surgery, age, sex body mass index, diabetes, smoking, renal function, steroid usage, preoperative albumin, preoperative hematocrit, perioperative blood transfusion (PBT), and operative time were assessed for association with the risk of infection within 30 days of RC using multivariable logistic regression...
December 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27388345/multicountry-survey-of-emergency-and-critical-care-medicine-physicians-fluid-resuscitation-practices-for-adult-patients-with-early-septic-shock
#4
Lauralyn McIntyre, Brian H Rowe, Timothy S Walsh, Alasdair Gray, Yaseen Arabi, Anders Perner, Anthony Gordon, John Marshall, Deborah Cook, Alison Fox-Robichaud, Sean M Bagshaw, Robert Green, Irwin Schweitzer, Alexis Turgeon, Ryan Zarychanski, Shane English, Michaël Chassé, Ian Stiell, Dean Fergusson
OBJECTIVES: Evidence to guide fluid resuscitation evidence in sepsis continues to evolve. We conducted a multicountry survey of emergency and critical care physicians to describe current stated practice and practice variation related to the quantity, rapidity and type of resuscitation fluid administered in early septic shock to inform the design of future septic shock fluid resuscitation trials. METHODS: Using a web-based survey tool, we invited critical care and emergency physicians in Canada, the UK, Scandinavia and Saudi Arabia to complete a self-administered electronic survey...
July 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27256181/procalcitonin-determined-at-emergency-department-as-na-early-indicator-of-progression-to-septic-shock-in-patient-with-sepsis-associated-with-ureteral-calculi
#5
Young Hwii Ko, Yoon Seob Ji, Sin-Youl Park, Su Jin Kim, Phil Hyun Song
INTRODUCTION: To investigate the role of initial procalcitonin (PCT) level as an early predictor of septic shock for the patient with sepsis induced by acute pyelonephritis (APN) secondary to ureteral calculi. MATERIALS AND METHODS: The data from 49 consecutive patients who met criteria of sepsis due to APN following ureteral stone were collected and divided into two groups: with (n=15) or without (n=34) septic shock. The clinical variables including PCT level for this outcome were retrospectively compared by univariate analysis, followed by multivariable logistic regression model...
March 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27062617/fluid-resuscitation-therapy-for-paediatric-sepsis
#6
REVIEW
Elliot Long, Trevor Duke
Sepsis and septic shock are the final common pathway for many decompensated paediatric infections. Fluid resuscitation therapy has been the cornerstone of haemodynamic resuscitation in these children. Good evidence for equivalence between 0.9% saline and 4% albumin, with the relative expense of the latter, has meant that 0.9% saline is currently the most commonly used resuscitation fluid world-wide. Evidence for harm from the chloride load in 0.9% saline has generated interest in balanced solutions as first line resuscitation fluids...
February 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/26957690/a-retrospective-cohort-study-of-perioperative-prognostic-factors-associated-with-intra-abdominal-sepsis
#7
R V Arun Kumar, Shivakumar M Channabasappa
CONTEXT: Intra-abdominal sepsis following laparotomy for acute abdomen remains still a challenging condition. The understanding of various perioperative risk factors by anesthesiologists are crucial in optimum management these patients. AIMS: The objective of this study is to assess the perioperative risk factors, which predicts the outcome of treatment. SETTINGS AND DESIGN: This retrospective observational study of 603 patients who underwent Laparotomies between March 2012 and March 2015 at our University Medical College...
January 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/26908009/predictors-of-early-progression-to-severe-sepsis-or-shock-among-emergency-department-patients-with-nonsevere-sepsis
#8
Andre L Holder, Namita Gupta, Elizabeth Lulaj, Miriam Furgiuele, Idaly Hidalgo, Michael P Jones, Tiphany Jolly, Paul Gennis, Adrienne Birnbaum
BACKGROUND: Progression from nonsevere sepsis-i.e., sepsis without organ failure or shock-to severe sepsis or shock among emergency department (ED) patients has been associated with significant mortality. Early recognition in the ED of those who progress to severe sepsis or shock during their hospital course may improve patient outcomes. We sought to identify clinical, demographic, and laboratory parameters that predict progression to severe sepsis, septic shock, or death within 96 h of ED triage among patients with initial presentation of nonsevere sepsis...
December 2016: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26847922/mortality-prediction-in-patients-with-severe-septic-shock-a-pilot-study-using-a-target-metabolomics-approach
#9
Manuela Ferrario, Alice Cambiaghi, Laura Brunelli, Silvia Giordano, Pietro Caironi, Luca Guatteri, Ferdinando Raimondi, Luciano Gattinoni, Roberto Latini, Serge Masson, Giuseppe Ristagno, Roberta Pastorelli
Septic shock remains a major problem in Intensive Care Unit, with high lethality and high-risk second lines treatments. In this preliminary retrospective investigation we examined plasma metabolome and clinical features in a subset of 20 patients with severe septic shock (SOFA score >8), enrolled in the multicenter Albumin Italian Outcome Sepsis study (ALBIOS, NCT00707122). Our purpose was to evaluate the changes of circulating metabolites in relation to mortality as a pilot study to be extended in a larger cohort...
February 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26844975/choice-of-fluid-therapy-in-the-initial-management-of-sepsis-severe-sepsis-and-septic-shock
#10
Ronald Chang, John B Holcomb
Sepsis results in disruption of the endothelial glycocalyx layer and damage to the microvasculature, resulting in interstitial accumulation of fluid and subsequently edema. Fluid resuscitation is a mainstay in the initial treatment of sepsis, but the choice of fluid is unclear. The ideal resuscitative fluid is one that restores intravascular volume while minimizing edema; unfortunately, edema and edema-related complications are common consequences of current resuscitation strategies. Crystalloids are recommended as first-line therapy, but the type of crystalloid is not specified...
July 2016: Shock
https://www.readbyqxmd.com/read/26736156/impact-of-postoperative-venous-thromboembolism-on-postoperative-morbidity-mortality-and-resource-utilization-after-hepatectomy
#11
Timothy E Newhook, Damien J LaPar, Dustin M Walters, Shruti Gupta, Joshua S Jolissaint, Reid B Adams, Kenneth L Brayman, Victor M Zaydfudim, Todd W Bauer
The impact of venous thromboembolism (VTE) after hepatectomy on patient morbidity, mortality, and resource usage remains poorly defined. Better understanding of thromboembolic complications is needed to improve perioperative management and overall outcomes. About 3973 patients underwent hepatectomy within NSQIP between 2005 and 2008. Patient characteristics, operative features, and postoperative correlates of VTE were compared with identify risk factors for VTE and to assess its overall impact on postoperative outcomes...
December 2015: American Surgeon
https://www.readbyqxmd.com/read/26640903/late-intensive-care-unit-admission-in-liver-transplant-recipients-10-year-experience
#12
Funda Atar, Ender Gedik, Şerife Kaplan, Pınar Zeyneloğlu, Arash Pirat, Mehmet Haberal
OBJECTIVES: We evaluated late intensive care unit admission in liver transplant recipients to identify incidences and causes of acute respiratory failure in the postoperative period and to compare these results with results in patients who did not have acute respiratory failure. MATERIALS AND METHODS: We retrospectively screened the data of 173 consecutive adult liver transplant recipients from January 2005 through March 2015 to identify patients with late admission (> 30 d posttransplant) to an intensive care unit...
November 2015: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/26571184/sequential-n-terminal-pro-b-type-natriuretic-peptide-and-high-sensitivity-cardiac-troponin-measurements-during-albumin-replacement-in-patients-with-severe-sepsis-or-septic-shock
#13
RANDOMIZED CONTROLLED TRIAL
Serge Masson, Pietro Caironi, Caterina Fanizza, Sara Carrer, Anselmo Caricato, Paola Fassini, Tarcisio Vago, Marilena Romero, Gianni Tognoni, Luciano Gattinoni, Roberto Latini
OBJECTIVES: Myocardial dysfunction is a frequent complication in patients with severe sepsis and can worsen the prognosis. We investigated whether circulating biomarkers related to myocardial function and injury predicted outcome and were associated with albumin replacement. DESIGN: A multicenter, randomized clinical trial about albumin replacement in severe sepsis or septic shock (the Albumin Italian Outcome Sepsis trial). SETTING: Forty ICUs in Italy...
April 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26541953/major-publications-in-the-critical-care-pharmacotherapy-literature-january-december-2014
#14
Sarah A Day, Michaelia Cucci, Molly E Droege, Jenna M Holzhausen, Bridgette Kram, Shawn Kram, Mehrnaz Pajoumand, Christine R Parker, Mona K Patel, Gregory J Peitz, Alia Poore, Charles J Turck, Megan A Van Berkel, Adrian Wong, Amanda Zomp, Megan A Rech
PURPOSE: Nine recently published articles and one guideline with important implications for critical care pharmacy practice are summarized. SUMMARY: The Critical Care Pharmacotherapy Literature Update (CCPLU) group includes more than 40 experienced critical care pharmacists across the United States. Group members monitor 29 peer-reviewed journals on an ongoing basis to identify literature relevant to pharmacy practice in the critical care setting. After evaluation by CCPLU group members, selected articles are chosen for summarization and distribution to group members nationwide based on applicability to practice, relevance, and study design and strength...
November 15, 2015: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/26474267/intravenous-immunoglobulin-in-septic-shock-review-of-the-mechanisms-of-action-and-meta-analysis-of-the-clinical-effectiveness
#15
Stefano Busani, Elisa Damiani, Ilaria Cavazzuti, Abele Donati, Massimo Girardis
INTRODUCTION: Sepsis is characterized by a complex immune response. In this study we aimed to provide a review of the mechanisms of action of immunoglobulin (Ig) related to sepsis and an updated meta-analysis of the clinical effectiveness of the Ig use in septic patients. EVIDENCE ACQUISITION: We performed two separate searches of Medline and other databases with the keywords Ig, sepsis, septic shock, septicemia, septicemia with no language restrictions in order to review the mechanisms of action of Igs in sepsis and to update the previous meta-analysis on the effects of the Ig therapy on the mortality of adult patients with septic shock...
May 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/26416404/increased-inflammatory-markers-with-altered-antioxidant-status-persist-after-clinical-recovery-from-severe-sepsis-a-correlation-with-low-hdl-cholesterol-and-albumin
#16
Lucie Vavrova, Jana Rychlikova, Magdalena Mrackova, Olga Novakova, Ales Zak, Frantisek Novak
Markers of oxidative stress and antioxidant status in relation to inflammatory mediators in septic patients (SPs) during the course of sepsis and after recovery were analysed. Patients were 30 critically ill adults in severe sepsis/septic shock, 19 of which completed 3 samplings (S1: within 24 h after onset of sepsis, S7: 7 days after S1, R7: 7 days after clinical recovery). Comparing SPs with healthy controls (HCs), enhanced C-reactive protein, procalcitonin, bilirubin and CuZn-superoxide dismutase activity were found at S1 only...
November 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26375122/sck-3-target-metabolomics-for-improving-early-prediction-of-death-in-patients-with-septic-shock
#17
A Cambiaghi, L Brunelli, P Caironi, M Ferrario, L Gattinoni, R Latini, S Masson, G Ristagno, R Pastorelli
INTRODUCTION: Elucidation of early metabolic signatures that predict survival in septic shock might help clinicians in prioritizing individual patient treatment. In this preliminary investigation, we examined plasma metabolome and clinical features in a subset of 20 patients with septic shock, enrolled in the multicenter Albumin Italian Outcome Sepsis (ALBIOS, NCT00707122). METHODS: Patients were divided into two groups according to their 28-days and 90-days survival...
October 2015: Shock
https://www.readbyqxmd.com/read/26313437/fluid-therapy-for-septic-shock-resuscitation-which-fluid-should-be-used
#18
REVIEW
Thiago Domingos Corrêa, Leonardo Lima Rocha, Camila Menezes Souza Pessoa, Eliézer Silva, Murillo Santucci Cesar de Assuncao
Early resuscitation of septic shock patients reduces the sepsis-related morbidity and mortality. The main goals of septic shock resuscitation include volemic expansion, maintenance of adequate tissue perfusion and oxygen delivery, guided by central venous pressure, mean arterial pressure, mixed or central venous oxygen saturation and arterial lactate levels. An aggressive fluid resuscitation, possibly in association with vasopressors, inotropes and red blood cell concentrate transfusion may be necessary to achieve those hemodynamic goals...
July 2015: Einstein
https://www.readbyqxmd.com/read/26238097/newly-designed-delta-neutrophil-index-to-serum-albumin-ratio-prognosis-of-early-mortality-in-severe-sepsis
#19
Yoon Jung Hwang, Sung Phil Chung, Yoo Seok Park, Hyun Soo Chung, Hye Sun Lee, Jong Woo Park, Jong Wook Lee, Jung Hwa Hong, Je Sung You, Incheol Park
PURPOSE: We evaluated the ratio of delta neutrophil index (DNI) to albumin (A) in patients receiving early goal-directed therapy (EGDT) to determine the prognostic significance of the DNI/A ratio as a marker of early mortality in critically ill patients with suspected sepsis. METHODS: We retrospectively analyzed records from a prospective EGDT registry in an emergency department (ED) and screened eligible adult patients who were admitted to the ED with severe sepsis and/or septic shock...
November 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26201326/bacterial-infections-in-cirrhosis
#20
Gregory J Botwin, Timothy R Morgan
Bacterial infections occur in 25-35 % of cirrhotics admitted to hospital. Health-care associated and hospital acquired (nosocomial) infections are the most common epidemiology, with community acquired infections less common (15-30 %). Spontaneous bacterial peritonitis and urinary infections are the most common sites, with spontaneous bacteremia, pneumonia, cellulitis and other sites being less common. The risk of infection is increased among subjects with more severe liver disease and an infection in the past 6 months...
September 2014: Hepatology International
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