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https://www.readbyqxmd.com/read/29679730/stand-alone-lateral-lumbar-interbody-fusion-for-the-treatment-of-symptomatic-adjacent-segment-degeneration-following-previous-lumbar-fusion
#1
Philip K Louie, Arya G Varthi, Ankur S Narain, Victor Lei, Daniel D Bohl, Grant D Shifflett, Frank M Phillips
BACKGROUND CONTEXT: Revision posterior decompression and fusion for patients with symptomatic ASD is associated with significant morbidity and is technically challenging. The use of a stand-alone LLIF in patients with symptomatic ASD may avoid many of the complications associated with revision posterior surgery. PURPOSE: To assess the clinical and radiographic outcomes of patients who underwent stand-alone lateral lumbar interbody fusion (LLIF) for symptomatic adjacent segment disease (ASD)...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679612/protein-arginine-methyltransferase-5-promotes-lung-cancer-metastasis-via-the-epigenetic-regulation-of-mir-99-family-fgfr3-signaling
#2
Pengyu Jing, Nan Zhao, Mingxiang Ye, Yong Zhang, Zhipei Zhang, Jianyong Sun, Zhengxin Wang, Jian Zhang, Zhongping Gu
Protein arginine methyltransferase 5 (PRMT5) functions as a tumor initiator to regulate several cancer progressions, such as proliferation and apoptosis, by catalyzing the symmetrical dimethylation (me2s) of arginine residues within targeted molecules. However, the exact role of PRMT5-mediated metastasis in lung cancer is not fully understood. Here, we illustrated its potential effects in lung cancer metastasis in vivo and vitro. PRMT5 was frequently overexpressed in lung tumors, and its expression was positively related to tumor stages, lymphatic metastasis and poor outcome...
April 18, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29679414/rates-and-features-of-methamphetamine-related-presentations-to-emergency-departments-an-integrative-literature-review
#3
REVIEW
Rikki Jones, Cindy Woods, Kim Usher
AIMS AND OBJECTIVES: To review the clinical impact methamphetamine has on emergency departments (ED) by assessing the available research on the rates and features of methamphetamine-related presentations. BACKGROUND: Globally, methamphetamine availability, distribution and use has rapidly increased. As a result, the number of methamphetamine-related presentations to EDs has also increased. In this context, it is timely to review the rate and features of methamphetamine-related presentations to understand the impact of methamphetamine on EDs and facilitate the allocation of services, staff and resources...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679395/placental-adaptations-to-micronutrient-dysregulation-in-the-programming-of-chronic-disease
#4
Pierre Hofstee, Daniel McKeating, Anthony V Perkins, James S M Cuffe
Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. The importance of micronutrients in gestational disorders is clearly understood but how they impact long term disease in humans requires further investigation...
April 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29679303/do-the-sglt-2-inhibitors-offer-more-than-hypoglycemic-activity
#5
REVIEW
Eduardo Flores, Carlos G Santos-Gallego, Nely Diaz-Mejía, Juan Jose Badimon
Type 2 diabetes mellitus (T2DM) is one of the most common chronic health conditions in the USA; it affects approximately 10% of adults with up to one-quarter being undiagnosed. T2DM is associated with substantial cardiovascular (CV) morbidity and mortality. T2DM is a pathological condition characterized by elevated levels of glucose and associated with high CV risk. Traditional hypoglycemic drugs have demonstrated their capability for effective and maintained management of high glucose levels, but they have not significantly impacted on the incidence of CV events...
April 20, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#6
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29679138/sexual-quality-of-life-body-image-distress-and-psychosocial-outcomes-in-colorectal-cancer-a-longitudinal-study
#7
Jennifer Barsky Reese, Elizabeth Handorf, Jennifer A Haythornthwaite
PURPOSE: The objectives were to assess changes in sexual QOL and body image distress over time and to examine longitudinal associations between sexual QOL and body image variables with psychosocial outcomes in a sample of colorectal cancer patients. METHODS: Participants (N = 141) completed a mail-based survey assessing sexual QOL [sexual distress (ISS), treatment impact on sexual function (SFQ), sexual function (FSFI; IIEF)], body image distress (BIS), and psychosocial outcomes [relationship quality (DAS-4), depressive symptoms (CESD-SF), and health-related QOL (HRQOL; FACT-C)]; 88 patients completed 6-month follow-up surveys (62%)...
April 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29679046/impact-of-antenatal-corticosteroids-in-preterm-neonates-based-on-maternal-body-mass-index
#8
Maheer Faden, Sarah D McDonald, Prakeshkumar S Shah, Amit Mukerji
OBJECTIVE: Impact of antenatal corticosteroid (ACS) in context of maternal body mass index (BMI) as it relates to neonatal outcomes remains unclear. We sought to evaluate effects of ACS on clinical outcomes of preterm infants based on maternal BMI. METHODS: We performed a retrospective cohort study among neonates 23-33 weeks' GA at a tertiary neonatal intensive care unit from 2011 to 2015. Outcomes of neonates exposed to any ACS and pre-pregnancy maternal BMI ≥ 25 (N = 491) were compared with maternal BMI < 25 (N = 484)...
April 20, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29678900/prevention-of-exacerbations-in-patients-with-stable-non-cystic-fibrosis-bronchiectasis-a-systematic-review-and-meta-analysis-of-pharmacological-and-non-pharmacological-therapies
#9
Abd Moain Abu Dabrh, Adam T Hill, Claudia C Dobler, Noor Asi, Wigdan H Farah, Qusay Haydour, Zhen Wang, Khalid Benkhadra, Larry J Prokop, Mohammad Hassan Murad
BACKGROUND: Several pharmacological and non-pharmacological therapies are used to treat stable bronchiectasis of non-cystic fibrosis (CF) aetiology. OBJECTIVE: We conducted a systematic review and meta-analysis to assess the evidence of the effectiveness of pharmacological and non-pharmacological treatment options in patients with stable non-CF bronchiectasis with a focus on reducing exacerbations. STUDY SELECTION: Multiple databases were searched through September 2017...
April 20, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29678703/anterior-controllable-antedisplacement-fusion-acaf-for-severe-cervical-ossification-of-the-posterior-longitudinal-ligament-comparison-with-anterior-cervical-corpectomy-with-fusion-accf
#10
Haisong Yang, Jingchuan Sun, Jiangang Shi, Guodong Shi, Yongfei Guo, Yong Yang
OBJECTIVE: Anterior cervical corpectomy and fusion (ACCF), in which a ventral constriction is resected, can decompress myelopathy and is considered the optimal treatment for ossification of the posterior longitudinal ligament (OPLL) up to now. However, its disadvantages are incomplete decompression, high surgery- and implant-related complication rates, and extremely surgical technique demanding. Our object was to introduce anterior controllable antedisplacement fusion (ACAF), a new surgical technique to treat OPLL, and compare it with ACCF...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678637/is-the-occlusion-site-of-the-lenticulostriate-artery-identified-on-admission-related-to-clinical-prognosis-in-patients-with-lacunar-stroke
#11
Masaki Naganuma, Yuichiro Inatomi, Makoto Nakajima, Takeshi Ohta, Toshiro Yonehara, Yukio Ando
BACKGROUND: The mechanism of lacunar stroke (LS) is rather speculative due to the lack of neuropathological evidence in clinical practice. To explore the significance of the occlusion site of the lenticulostriate artery (LSA) to this mechanism, we investigated the characteristics and prognosis of patients with LS with proximal occlusions. MATERIALS AND METHODS: We studied 202 patients with acute LS in the region of the LSA. The presumed occlusion site of the LSA was assessed on coronal, diffusion-weighted magnetic resonance images...
April 17, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29678528/endocrine-remission-after-pituitary-stereotactic-radiosurgery-differences-in-rates-of-response-for-matched-cohorts-of-cushing-disease-and-acromegaly-patients
#12
Daniel M Trifiletti, Zhiyuan Xu, Sunil W Dutta, Alfredo Quiñones-Hinojosa, Jennifer Peterson, Mary Lee Vance, Jason P Sheehan
PURPOSE: To compare and describe the time to endocrine remission and new hypopituitarism among patients with growth hormone (GH) and adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas after radiosurgery, controlling for several known prognostic factors. METHODS AND MATERIALS: An institutional review board-approved, institutional retrospective analysis of patients with GH- and ACTH-secreting pituitary adenomas was performed, with matching for patient sex, age at radiosurgery, interval between the last resection and radiosurgery, use of previous radiation therapy, whole sella treatment, suprasellar extension, cavernous sinus invasion, and margin dose...
February 20, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29678514/effect-of-neoadjuvant-therapy-and-rectal-surgery-on-health-related-quality-of-life-in-patients-with-rectal-cancer-during-the-first-2-years-after-diagnosis
#13
Alice M Couwenberg, Johannes P M Burbach, Wilhelmina M U van Grevenstein, Anke B Smits, Esther C J Consten, Anandi H W Schiphorst, Niels A T Wijffels, Joost T Heikens, Martijn P W Intven, Helena M Verkooijen
INTRODUCTION: Rectal cancer surgery with neoadjuvant therapy is associated with substantial morbidity. The present study describes the course of quality of life (QOL) in rectal cancer patients in the first 2 years after the start of treatment. PATIENTS AND METHODS: We performed a prospective study within a colorectal cancer cohort including rectal cancer patients who were referred for neoadjuvant chemoradiation or short-course radiotherapy and underwent rectal surgery...
March 21, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29678512/galectin-3-is-associated-with-left-ventricular-reverse-remodeling-and-outcome-after-percutaneous-mitral-valve-repair
#14
Christine S Zuern, Niklas Floss, Iris I Mueller, Christian Eick, Martin Duckheim, Johannes Patzelt, Meinrad Gawaz, Andreas E May, Karin A L Mueller
BACKGROUND: Plasma Galectin-3 is a marker of myocardial inflammation and fibrosis, was associated with left ventricular (LV) reverse remodeling after conventional surgical mitral valve repair (MVR) and predicted clinical events in patients undergoing transcatheter aortic valve replacement (TAVR). We aimed to evaluate the association between pre-interventional Galectin-3 levels and (1) reverse LV remodeling and (2) major adverse cardiovascular events (MACE) in patients undergoing percutaneous MVR...
April 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29678506/association-between-bmi-and-risk-of-severe-hypoglycaemia-in-type-2-diabetes
#15
J-S Yun, Y-M Park, K Han, S-A Cha, Y-B Ahn, S-H Ko
AIM: This study aimed to assess the association between body mass index (BMI) and the development of severe hypoglycaemia in patients with type 2 diabetes (T2D), using nationwide data for the entire South Korean population. METHODS: The association between BMI and severe hypoglycaemia was retrospectively examined from claims and National Health examination data registered between 2002 and 2015. A total of 1,366,692 subjects assigned clinical codes for T2D and prescribed antihypoglycaemic agents were included...
April 6, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29678410/health-literacy-in-children-with-asthma-a-systematic-review
#16
REVIEW
Yu-Fen Tzeng, Bor-Luen Chiang, Yu-Hsia Chen, Bih-Shya Gau
Health literacy (HL) is a key factor influencing asthma management outcomes and has primarily been focused on adult patients. The relationship between children's HL and asthma is unclear, and several research gaps are present in the direct assessment of children's HL. In this study, a systematic review of the relevant literature was conducted to elucidate the relationship between HL and asthma among children. An electronic database search was performed to obtain studies published between January 2005-August 2016...
December 8, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29678373/retrospective-study-of-eligibility-for-orthognathic-surgery-using-the-index-of-orthognathic-functional-treatment-need-ioftn
#17
P Fowler, T King, M Lee, J Erasmus
To assess the functional needs of orthognathic patients who had been accepted for treatment by Christchurch Hospital, New Zealand, we made a retrospective assessment of 80 consecutive patients using the Index of Orthognathic Functional Treatment Need (IOFTN). Eligibility was based on the Severity and Outcome Index (SOI) score of ≤3 derived from seven lateral cephalometric measurements (three skeletal, three dental, and one soft tissue), which made allowances for asymmetrical or reported important functional issues...
April 17, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29678337/relation-of-coronary-culprit-lesion-morphology-determined-by-optical-coherence-tomography-and-cardiac-outcomes-to-serum-uric-acid-levels-in-patients-with-acute-coronary-syndrome
#18
Nobuaki Kobayashi, Noritake Hata, Masafumi Tsurumi, Yusaku Shibata, Hirotake Okazaki, Akihiro Shirakabe, Masamichi Takano, Yoshihiko Seino, Wataru Shimizu
The aims of the present study were to elucidate features of culprit lesion plaque morphology using optical coherence tomography (OCT) in relation to elevated serum uric acid (sUA) levels and to clarify the impact of sUA levels on adverse clinical outcomes in patients with acute coronary syndrome (ACS). Clinical data and outcomes were compared between ACS patients with sUA ≥6 mg/dl (high-sUA; n = 506) and sUA <6.0 mg/dl (low-sUA; n = 608). Angiography and OCT findings were analyzed in patients with preintervention OCT and compared between groups of high-sUA (n = 206) and low-sUA (n = 273)...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29678324/time-series-study-of-weather-water-quality-and-acute-gastroenteritis-at-water-safety-plan-implementation-sites-in-france-and-spain
#19
Karen E Setty, Jerome Enault, Jean-Francois Loret, Claudia Puigdomenech Serra, Jordi Martin-Alonso, Jamie Bartram
Water Safety Plans (WSPs), recommended by the World Health Organization since 2004, can help drinking water suppliers to proactively identify potential risks and implement preventive barriers that improve safety. Few studies have investigated long-term impacts of WSPs, such as changes in drinking water quality or public health; however, some evidence from high-income countries associates WSP implementation with a reduction in diarrheal disease. To validate the previously observed linkages between WSPs and health outcomes, this time series study examined site-specific relationships between water-related exposures and acute gastroenteritis rates at three locations in France and Spain, including the role of WSP status...
April 6, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29678294/association-between-body-mass-index-and-clinical-outcomes-of-patients-after-cardiac-arrest-and-resuscitation-a-meta-analysis
#20
REVIEW
Ye Ma, Lili Huang, Lu Zhang, Hai Yu, Bin Liu
BACKGROUND: Obesity as one of the risk factors for cardiovascular diseases increases mortality in general population. Several clinical studies investigated clinical outcomes in patients with different body mass index (BMI) after cardiac arrest (CA). Controversial data regarding BMI on clinical outcomes in those patients exist in those studies. Therefore, we conducted a meta-analysis to evaluate the effect of BMI on survival condition and neurological prognosis in those patients. METHODS: We searched Pubmed, Embase, Ovid/Medline and EBM reviews databases for relational studies investigating the association between BMI and clinical outcomes of patients after CA...
April 6, 2018: American Journal of Emergency Medicine
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