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Functional Assesment

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https://www.readbyqxmd.com/read/28605001/determination-of-structural-femoral-head-allograft-viability-and-integrity-with-a-novel-diagnostic-tool-spect-ct-a-preliminary-study
#1
Kasım Kilicarslan, Nadir Yalcin, Vedat Bicici, Elif Ozdemir, Izzet Bingol, Seyda Turkolmez
OBJECTIVE: To evaluate the viability and integrity of fresh frozen bulk femoral head allografts obtained from the institutional bone bank that were used to reconstruct severe acetabular defects and to validate the SPECT/CT method which gives both anatomical and functional data for this purpose. METHODS: We retrospectively reviewed 9 patients (6 female, 3 male; mean age 63.6 years). Preoperative and postoperative leg lengths, existence of the Trendelenburg sign, range of motion of the hip, visual analogue score (VAS), Harris Hip Score (HHS) and any complication were assesed at each follow-up...
June 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28589667/in-vitro-and-in-vivo-assesment-of-lactic-acid-modified-chitosan-scaffolds-for-potential-treatment-of-full-thickness-burns
#2
Cristina Velasquillo, Phaedra Silva-Bermudez, Nadia Vázquez, Alan Martínez, Andres Espadín, Julieta García-López, Antonio Medina-Vega, Hugo Lecona, Raúl Pichardo, Clemente Ibarra, Keiko Shirai
Autologous skin transplantation is today₹s "gold standard" treatment for full-thickness burns. However, when more than 30% of total body surface area is damaged, there is an important shortage of autologous donor sites for skin grafting; then, treatment alternatives become crucial. Such alternatives can be based on polymeric scaffolds capable of functioning as protective covers and cells/factors carriers. Chitosan (CTS) is a natural-derived polymer with relevant biological-related properties but poor mechanical performance...
June 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28589290/validation-of-a-single-summary-score-for-the-prolapse-incontinence-sexual-questionnaire-iuga-revised-pisq-ir
#3
Melissa L Constantine, Rachel N Pauls, Rebecca R Rogers, Todd H Rockwood
INTRODUCTION AND HYPOTHESIS: The Prolapse/Incontinence Sexual Questionnaire-International Urogynecology Association (IUGA) Revised (PISQ-IR) measures sexual function in women with pelvic floor disorders (PFDs) yet is unwieldy, with six individual subscale scores for sexually active women and four for women who are not. We hypothesized that a valid and responsive summary score could be created for the PISQ-IR. METHODS: Item response data from participating women who completed a revised version of the PISQ-IR at three clinical sites were used to generate item weights using a magnitude estimation (ME) and Q-sort (Q) approaches...
June 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28549793/clinical-residual-symptomatology-and-associated-factors-in-multiple-organ-failure-survivors-a-long-term-mortgage
#4
S Rodríguez-Villar, J L Rodríguez-García, J Arévalo-Serrano, M Sánchez-Casado, H Fletcher
PURPOSE: To evaluate which clinical residual symptoms, multiorgan failure (MOF) patients may exhibit following discharge from intensive care unit (ICU) and to identify the associated factors. MATERIAL AND METHODS: A total of 545 consecutively admitted adult patients with MOF on admission were included in the study. Patients were assesed by a survey 6 and 12 months after discharge from a medical-surgical ICU in Spain. A telephone survey was conducted concerning the clinical symptoms of their stay in ICU...
May 23, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28520420/local-descriptors-of-dynamic-and-nondynamic-correlation
#5
Eloy Ramos-Cordoba, Eduard Matito
Quantitatively accurate electronic structure calculations rely on the proper description of electron correlation. A judicious choice of the approximate quantum chemistry method depends upon the importance of dynamic and nondynamic correlation, which is usually assesed by scalar measures. Existing measures of electron correlation do not consider separately the regions of the Cartesian space where dynamic or nondynamic correlation are most important. We introduce real-space descriptors of dynamic and nondynamic electron correlation that admit orbital decomposition...
June 2, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28482366/agreement-and-reliability-of-fasted-and-oral-glucose-tolerance-test-derived-indices-of-insulin-sensitivity-and-beta-cell-function-in-boys
#6
Emma Joanne Cockcroft, Craig Anthony Williams, Sarah Rebecca Jackman, Neil Armstrong, Alan R Barker
Assessment of plasma insulin and glucose outcomes is important in paediatric studies aimed at reducing future risk of type 2 diabetes and cardiovascular disease. The aims of this study are to determine the between-method agreement and the day-to-day reliability of fasting and oral glucose tolerance test (OGTT)-derived estimates of insulin sensitivity and β-cell function in healthy boys. Fasting and OGTT assesments of insulin resistance and β-cell function were performed on 28 boys (12.3±2.9 years). Measurements were repeated after 1 week (fasting, n=28) and 1 day (OGTT, n=8)...
June 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28290728/diffuse-large-b-cell-lymphoma-in-the-elderly-standard-treatment-and-new-perspectives
#7
REVIEW
Annalisa Chiappella, Alessia Castellino, Maura Nicolosi, Elisa Santambrogio, Umberto Vitolo
Diffuse large B-cell lymphoma (DLBCL) is the most common histotype in non Hodgkin lymphoma, with a peak incidence in the sixth decade. The standard treatment for elderly FIT DLBCL patients is Rituximab-CHOP; in unfit and frail patients, chemotherapy at reduced intensity should be considered. Areas covered: In this article, we will review use of standard therapies and new drugs investigated such as immonomudulating agents (IMiDs), Bruton Tyrosine Kinase (BTK), in fit, unfit, frail and very elderly DLCBL patients...
April 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28230069/consistent-role-of-quaternary-climate-change-in-shaping-current-plant-functional-diversity-patterns-across-european-plant-orders
#8
Alejandro Ordonez, Jens-Christian Svenning
Current and historical environmental conditions are known to determine jointly contemporary species distributions and richness patterns. However, whether historical dynamics in species distributions and richness translate to functional diversity patterns remains, for the most part, unknown. The geographic patterns of plant functional space size (richness) and packing (dispersion) for six widely distributed orders of European angiosperms were estimated using atlas distribution data and trait information. Then the relative importance of late-Quaternary glacial-interglacial climate change and contemporary environmental factors (climate, productivity, and topography) as determinants of functional diversity of evaluated orders was assesed...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188757/cognitive-effects-of-androgen-deprivation-therapy-in-men-with-advanced-prostate-cancer
#9
Bulent Gunlusoy, Yasin Ceylan, Aslı Koskderelioglu, Muhtesem Gedizlioglu, Tansu Degirmenci, Pınar Ortan, Zafer Kozacioglu
OBJECTIVE: To evaluate the prostate cancer effects of androgen deprivation therapy (ADT) by using a systematic set of methods to calculate specific cognitive functions in men with locally advanced or metastatic prostate cancer. MATERIALS AND METHODS: From April 2014 to February 2016, a prospective, comparative study was done to evaluate the cognitive effects of hormone therapy. Group 1 consisted of 78 patients with locally advanced or metastatic prostate cancer who received complete ADT treatment continuously for 12 months and group 2 (control group) consisted of 78 patients who underwent radical prostatectomy without any additional treatment...
February 7, 2017: Urology
https://www.readbyqxmd.com/read/28124624/accessing-gap-junction-channel-structure-function-relationships-through-molecular-modeling-and-simulations
#10
REVIEW
F Villanelo, Y Escalona, C Pareja-Barrueto, J A Garate, I M Skerrett, T Perez-Acle
BACKGROUND: Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells. These channels allow intercellular transfer of molecules up to ~1 kDa, including water, ions and other metabolites. Unveiling structure-function relationships coded into the molecular architecture of these channels is necessary to gain insight on their vast biological function including electrical synapse, inflammation, development and tissular homeostasis. From early works, computational methods have been critical to analyze and interpret experimental observations...
January 17, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/27992361/risk-factors-that-affect-metabolic-health-status-in-obese-children
#11
COMPARATIVE STUDY
Selin Elmaogullari, Fatma Demirel, Nihal Hatipoglu
BACKGROUND: While some obese children are metabolically healthy (MHO), some have additional health problems, such as hypertension, dyslipidemia, insulin resistance, and hepatosteatosis, which increase mortality and morbidity related to cardiovascular diseases (CVD) during adulthood. These children are metabolically unhealthy obese (MUO) children. In this study we assessed the factors that affect metabolic health in obesity and the clinical and laboratory findings that distinguish between MHO and MUO children...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27814573/assessment-of-hypoxia-and-tnf-alpha%C3%A2-response-by-a-vector-with-hre-and-nf-kappab-response-elements
#12
Zhilin Chen, Ashley L Eadie, Sean R Hall, Laurel Ballantyne, David Ademidun, M Yat Tse, Stephen C Pang, Luis G Melo, Christopher A Ward, Keith R Brunt
Hypoxia and inflammatory cytokine activation (H&I) are common processes in many acute and chronic diseases. Thus, a single vector that responds to both hypoxia and inflammatory cytokines, such as TNF-alpha, is useful for assesing the severity of such diseases. Adaptation to hypoxia is regulated primarily by hypoxia inducible transcription factor (HIF alpha) nuclear proteins that engage genes containing a hypoxia response element (HRE). Inflammation activates a multitude of cytokines, including TNF-alpha, that invariably modulate activation of the nuclear factor kappa B (NF-kB) transcription factor...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27746359/role-of-non-mulberry-silk-fibroin-in-deposition-and-regulation-of-extracellular-matrix-towards-accelerated-wound-healing
#13
Dimple Chouhan, Bijayshree Chakraborty, Samit K Nandi, Biman B Mandal
Bombyx mori silk fibroin (BMSF) as biopolymer has been extensively explored in wound healing applications. However, limited study is available on the potential of silk fibroin (SF) from non-mulberry (Antheraea assama and Philosamia ricini) silk variety. Herein, we have developed non-mulberry SF (NMSF) based electrospun mats functionalized with epidermal growth factor (EGF) and ciprofloxacin HCl as potential wound dressing. The NMSF based mats exhibited essential properties of wound dressing like biocompatibility, high water retention capacity (440%), water vapor transmission rate (∼2330gm(-2)day(-1)), high elasticity (∼2...
January 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27723553/the-evaluation-of-endothelial-function-and-structure-in-hirsute-patients-in-reproductive-age
#14
Kemal Atasayan, Tevfik Yoldemir, Sedef Ramoglu, Dilek Gogas Yavuz
OBJECTIVE: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age. STUDY DESIGN: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27457568/music-therapy-in-huntington-s-disease-a-protocol-for-a-multi-center-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Monique van Bruggen-Rufi, Annemieke Vink, Wilco Achterberg, Raymund Roos
BACKGROUND: Huntington's disease is a progressive, neurodegenerative disease with autosomal dominant inheritance, characterized by motor disturbances, cognitive decline and behavioral and psychological symptoms. Since there is no cure, all treatment is aimed at improving quality of life. Music therapy is a non-pharmacological intervention, aiming to improve the quality of life, but its use and efficacy in patients with Huntington's disease has hardly been studied. In this article, a protocol is described to study the effects of music therapy in comparison with a control intervention to improve quality of life through stimulating expressive and communicative skills...
July 26, 2016: BMC Psychology
https://www.readbyqxmd.com/read/27392843/impairments-of-postural-stability-core-endurance-fall-index-and-functional-mobility-skills-in-patients-with-patello-femoral-pain-syndrome
#16
Gul Deniz Yilmaz Yelvar, Yasemin Çirak, Murat Dalkilinç, Yasemin Parlak Demir, Gul Baltaci, Mahmut Kömürcü, Gul Deniz Yilmaz Yelvar
BACKGROUND: Postural control allows performance of daily and sports activities. The previous studies show that postural sway inceases in orthopaedic injuries such as osteoarthritis and total knee arthroplasty. OBJECTIVE: To compare postural sway, risk of falling and function between individuals with and without patellofemoral pain syndrome (PFS). METHODS: This study included 22 subjects with patellofemoral pain syndrome, age-matched pain-free 22 females serving as a control group...
June 30, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27377817/oxygen-saturation-minute-heart-rate-index-simple-lung-function-test-for-children
#17
Ali Ozdemir, Dilek Dogruel, Ozlem Yilmaz
BACKGROUND: The severity of airway obstruction can be accurately determined on spirometry in children with asthma. Other assessments may include peak expiratory flow and pulse oximetry. In the present study, we evaluated the validity and reliability of oxygen saturation/minute heart rate (SpO2 /MHR) index in the prediction of degree of severe airway obstruction in children with asthma. METHODS: This was a retrospective study of children aged 7-17 followed for asthma at Mersin Women and Children's Hospital...
July 5, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27160758/inflammation-endothelial-dysfunction-and-arterial-stiffness-as-therapeutic-targets-in-cardiovascular-medicine
#18
Vittoriano Della Corte, Antonino Tuttolomondo, Rosaria Pecoraro, Domenico Di Raimondo, Valerio Vassallo, Antonio Pinto
In the last decades, many factors thought to be associated with the atherosclerotic process and cardiovascular events have been studied, and some of these have been shown to correlate with clinical outcome, such as arterial stiffness, endothelial dysfunction and immunoinflammatory markers. Arterial stiffness is an important surrogate marker that describes the capability of an artery to expand and contract in response to pressure changes. It can be assessed with different techniques, such as the evaluation of PWV and AIx...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27079224/sensitivity-and-specificity-of-assesment-instruments-of-quality-of-life-in-rheumatoid-arthritis
#19
Silvana Almeida Ribas, Selena Dubois Mendes, Laís Bittencourt Pires, Rafaela Brito Viegas, Israel Souza, Maurício Barreto, Martha Castro, Abrahão Fontes Baptista, Katia Nunes Sá
OBJECTIVE: To check sensitivity and specificity of assessment instruments of QoL in patients with Rheumatoid Arthritis (RA). METHODOLOGY: Accuracy study in a sample consisting of patients with confirmed diagnosis of RA. QoL questionnaires QV SF-36 (Gold Standard), HAQ and NHP were applied. The Pearson Correlation Coefficient, ROC curve, AUC and Youden Index (J) were used to analyze the data. RESULTS: This study enrolled 97 individuals with RA...
March 24, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/26987620/extracorporeal-shock-wave-therapy-for-breast-cancer-related-lymphedema-a-pilot-study
#20
Mehtap Aykac Cebicci, Serap Tomruk Sutbeyaz, Sema Sezgin Goksu, Sehriban Hocaoglu, Arzu Oguz, Ayse Atilabey
OBJECTIVE: To investigate the clinical effect of extracorporeal shock wave therapy (ESWT) in patients with secondary lymphedema after breast cancer treatment. DESIGN: Prospective clinical pilot study. SETTING: Education and research hospital. PARTICIPANTS: Women with a diagnosis of lymphedema secondary to breast cancer (N=11). INTERVENTIONS: Patients were treated for 12 sessions of ESWT with 2500 impulses each...
September 2016: Archives of Physical Medicine and Rehabilitation
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