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Functional Assesment

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https://www.readbyqxmd.com/read/27814573/assessment-of-hypoxia-and-tnf-alpha%C3%A2-response-by-a-vector-with-hre-and-nf-kappab-response-elements
#1
Zhilin Chen, Ashley L Eadie, Sean R Hall, Laurel Ballantyne, David Ademidun, M Yat Tse, Stephen C Pang, Luis G Melo, Christopher A Ward, Keith R Brunt
Hypoxia and inflammatory cytokine activation (H&I) are common processes in many acute and chronic diseases. Thus, a single vector that responds to both hypoxia and inflammatory cytokines, such as TNF-alpha, is useful for assesing the severity of such diseases. Adaptation to hypoxia is regulated primarily by hypoxia inducible transcription factor (HIF alpha) nuclear proteins that engage genes containing a hypoxia response element (HRE). Inflammation activates a multitude of cytokines, including TNF-alpha, that invariably modulate activation of the nuclear factor kappa B (NF-kB) transcription factor...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27746359/role-of-non-mulberry-silk-fibroin-in-deposition-and-regulation-of-extracellular-matrix-towards-accelerated-wound-healing
#2
Dimple Chouhan, Bijayshree Chakraborty, Samit K Nandi, Biman B Mandal
: Bombyx mori silk fibroin (BMSF) as biopolymer has been extensively explored in wound healing applications. However, limited study is available on the potential of silk fibroin (SF) from non-mulberry (Antheraea assama and Philosamia ricini) silk variety. Herein, we have developed non-mulberry SF (NMSF) based electrospun mats functionalized with epidermal growth factor (EGF) and ciprofloxacin HCl as potential wound dressing. The NMSF based mats exhibited essential properties of wound dressing like biocompatibility, high water retention capacity (440%), water vapor transmission rate (∼2330gm(-2)day(-1)), high elasticity (∼2...
October 13, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27723553/the-evaluation-of-endothelial-function-and-structure-in-hirsute-patients-in-reproductive-age
#3
Kemal Atasayan, Tevfik Yoldemir, Sedef Ramoglu, Dilek Gogas Yavuz
OBJECTIVE: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age. STUDY DESIGN: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group...
October 3, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27457568/music-therapy-in-huntington-s-disease-a-protocol-for-a-multi-center-randomized-controlled-trial
#4
Monique van Bruggen-Rufi, Annemieke Vink, Wilco Achterberg, Raymund Roos
BACKGROUND: Huntington's disease is a progressive, neurodegenerative disease with autosomal dominant inheritance, characterized by motor disturbances, cognitive decline and behavioral and psychological symptoms. Since there is no cure, all treatment is aimed at improving quality of life. Music therapy is a non-pharmacological intervention, aiming to improve the quality of life, but its use and efficacy in patients with Huntington's disease has hardly been studied. In this article, a protocol is described to study the effects of music therapy in comparison with a control intervention to improve quality of life through stimulating expressive and communicative skills...
2016: BMC Psychology
https://www.readbyqxmd.com/read/27392843/impairments-of-postural-stability-core-endurance-fall-index-and-functional-mobility-skills-in-patients-with-patello-femoral-pain-syndrome
#5
Gul Deniz Yilmaz Yelvar, Yasemin Çirak, Murat Dalkilinç, Yasemin Parlak Demir, Gul Baltaci, Mahmut Kömürcü, Gul Deniz Yilmaz Yelvar
BACKGROUND: Postural control allows performance of daily and sports activities. The previous studies show that postural sway inceases in orthopaedic injuries such as osteoarthritis and total knee arthroplasty. OBJECTIVE: To compare postural sway, risk of falling and function between individuals with and without patellofemoral pain syndrome (PFS). METHODS: This study included 22 subjects with patellofemoral pain syndrome, age-matched pain-free 22 females serving as a control group...
June 30, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27377817/oxygen-saturation-minute-heart-rate-index-simple-lung-function-test-for-children
#6
Ali Ozdemir, Dilek Dogruel, Ozlem Yilmaz
BACKGROUND: The severity of airway obstruction can be accurately determined on spirometry in children with asthma. Other assessments may include peak expiratory flow and pulse oximetry. In the present study, we evaluated the validity and reliability of oxygen saturation/minute heart rate (SpO2 /MHR) index in the prediction of degree of severe airway obstruction in children with asthma. METHODS: This was a retrospective study of children aged 7-17 followed for asthma at Mersin Women and Children's Hospital...
July 5, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27160758/inflammation-endothelial-dysfunction-and-arterial-stiffness-as-therapeutic-targets-in-cardiovascular-medicine
#7
Vittoriano Della Corte, Antonino Tuttolomondo, Rosaria Pecoraro, Domenico Di Raimondo, Valerio Vassallo, Antonio Pinto
In the last decades, many factors thought to be associated with the atherosclerotic process and cardiovascular events have been studied, and some of these have been shown to correlate with clinical outcome, such as arterial stiffness, endothelial dysfunction and immunoinflammatory markers. Arterial stiffness is an important surrogate marker that describes the capability of an artery to expand and contract in response to pressure changes. It can be assessed with different techniques, such as the evaluation of PWV and AIx...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27079224/sensitivity-and-specificity-of-assesment-instruments-of-quality-of-life-in-rheumatoid-arthritis
#8
Silvana Almeida Ribas, Selena Dubois Mendes, Laís Bittencourt Pires, Rafaela Brito Viegas, Israel Souza, Maurício Barreto, Martha Castro, Abrahão Fontes Baptista, Katia Nunes Sá
OBJECTIVE: To check sensitivity and specificity of assessment instruments of QoL in patients with Rheumatoid Arthritis (RA). METHODOLOGY: Accuracy study in a sample consisting of patients with confirmed diagnosis of RA. QoL questionnaires QV SF-36 (Gold Standard), HAQ and NHP were applied. The Pearson Correlation Coefficient, ROC curve, AUC and Youden Index (J) were used to analyze the data. RESULTS: This study enrolled 97 individuals with RA...
March 24, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/26987620/extracorporeal-shock-wave-therapy-for-breast-cancer-related-lymphedema-a-pilot-study
#9
Mehtap Aykac Cebicci, Serap Tomruk Sutbeyaz, Sema Sezgin Goksu, Sehriban Hocaoglu, Arzu Oguz, Ayse Atilabey
OBJECTIVE: To investigate the clinical effect of extracorporeal shock wave therapy (ESWT) in patients with secondary lymphedema after breast cancer treatment. DESIGN: Prospective clinical pilot study. SETTING: Education and research hospital. PARTICIPANTS: Women with a diagnosis of lymphedema secondary to breast cancer (N=11). INTERVENTIONS: Patients were treated for 12 sessions of ESWT with 2500 impulses each...
September 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/26983415/tobacco-use-is-associated-with-reduced-amplitude-and-intensity-dependence-of-the-cortical-auditory-evoked-n1-p2-component
#10
Philippe Jawinski, Nicole Mauche, Christine Ulke, Jue Huang, Janek Spada, Cornelia Enzenbach, Christian Sander, Ulrich Hegerl, Tilman Hensch
RATIONALE: Tobacco use is linked to cerebral atrophy and reduced cognitive performance in later life. However, smoking-related long-term effects on brain function remain largely uncertain. Previous studies suggest that nicotine affects serotonergic signaling, and the intensity dependence (alias loudness dependence) of the auditory evoked N1-P2 potential has been proposed as a marker of serotonergic neurotransmission. OBJECTIVE: In the present study, we assesed the effects of chronic smoking on amplitude and intensity dependence of the auditory evoked N1-P2 potential...
June 2016: Psychopharmacology
https://www.readbyqxmd.com/read/26848794/quantitative-and-semi-quantitative-histopathological-examination-of-renal-biopsies-in-healthy-individuals-and-associations-with-kidney-function
#11
Yael Bar, Lars Barregard, Gerd Sallsten, Maria Wallin, Johan Mölne
This study assesed the prevalence of histopathological changes in renal biopsies from healthy individuals, and the association with age, sex and smoking. Donor biopsies from 109 subjects were obtained from living kidney donors, and blood and urine samples were collected together with medical history. All biopsies were scored according to the Banff '97 classification with some modifications. The parameters included in this study were tubular atrophy, interstitial fibrosis, glomerulosclerosis, arteriosclerosis, arteriolohyalinosis and a sclerosis score...
May 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/26841152/is-mild-cognitive-impairment-a-precursor-of-alzheimer-s-disease-short-review
#12
REVIEW
Jana Janoutová, Omar Šerý, Ladislav Hosák, Vladimír Janout
Mild Cognitive Impairment (MCI) may be a precursor of Alzheimer's disease (AD). There is a boundary area between normal aging and dementia. In practice, the term "age related cognitive decline" has been used interchangeably with "normal aging". Alternatively, the term "aging associated cognitive decline" was introduced and defined by a performance on a standardized cognitive scale focused on learning and memory, attention and cognitive speed, language, or visuoconstructional abilities. The term "mild cognitive impairment" was adopted by Petersen in 2004 to describe a period in the course of neurodegenerative disease where cognition is no longer normal relative to age expectations, however, daily functions are not sufficiently disrupted to correlate with the diagnosis of dementia...
December 2015: Central European Journal of Public Health
https://www.readbyqxmd.com/read/26691941/-retrospective-ngs-study-in-high-risk-hereditary-cancer-patients-at-masaryk-memorial-cancer-institute
#13
E Macháčková, J Hazova, E Sťahlová Hrabincová, P Vašíčková, M Navrátilová, M Svoboda, L Foretová
BACKGROUND: Currently, more than 200 hereditary cancer syndromes have been described, yet, in most countries genetic testing is restricted to a narrow spectrum of genes within a limited group of people tested. METHODS: For this retrospective study we used the TruSight cancer panel (Illumina)--NGS panel targeting 94 cancer predisposition genes in order to analyze 50 high-risk cancer patients with significant personal and family history of cancer who did not carry mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6, TP53 or APC genes...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/26672630/-18f-fdg-pet-ct-for-the-assessment-of-the-volume-of-the-spleen
#14
Peter Smeets, Gilles Mees, Hamphrey Ham, Alex Maes, Koenraad Verstraete, Christophe Van De Wiele
BACKGROUND: The aim of this study was to report on the feasibility and accuracy of spleen volume determination on FDG PET/CT imaging using region growing and the CT part of the PET/CT examination as anatomical landmark (PET-CT based spleen volume method PBM) and volume summation of axial CT sections of the spleen as gold standard (true spleen volume (TSV). We also aimed to compare results obtained to the estimative methods (ESV). METHODS: Thirty-nine FDG PET/CT images taken from 32 patients (15 women, age range: 16-83 years) suffering from lymphoma, covering a wide range of spleen volumes based on visual CT assessment, in whom CT as well as FDG PET images revealed no focal spleen abnormalities were included for analysis...
March 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26530648/cemented-versus-uncemented-arthroplasty-in-patients-with-a-displaced-fracture-of-the-femoral-neck-a-randomised-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
C Inngul, R Blomfeldt, S Ponzer, A Enocson
The aim of this randomised controlled study was to compare functional and radiological outcomes between modern cemented and uncemented hydroxyapatite coated stems after one year in patients treated surgically for a fracture of the femoral neck. A total of 141 patients aged > 65 years were included. Patients were randomised to be treated with a cemented Exeter stem or an uncemented Bimetric stem. The patients were reviewed at four and 12 months. The cemented group performed better than the uncemented group for the Harris hip score (78 vs 70...
November 2015: Bone & Joint Journal
https://www.readbyqxmd.com/read/26476486/metabolic-effects-of-supplementation-with-vitamin-d-in-type-2-diabetic-patients-with-vitamin-d-deficiency
#16
José María Calvo-Romero, José Manuel Ramiro-Lozano
AIM: Epidemiological studies suggest that vitamin D status influences type 2 diabetes mellitus. We investigate the metabolic effects of vitamin D. MATERIAL AND METHODS: We studied consecutive type 2 diabetic patients without insulin therapy with vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) lower than 20ng/ml). They were treated with 16,000IU of calcifediol orally once a week for a minimum of 8 weeks. RESULTS: Twenty eight patients were treated for a mean time of 84...
April 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/26373394/expeditious-entry-to-functionalized-pseudo-peptidic-organoselenide-redox-modulators-via-sequential-ugi-sn-methodology
#17
Saad Shaaban, Amr Negm, Mohamed A Sobh, Ludger A Wessjohann
An efficient route towards the synthesis of symmetrical diselenide and seleniumcontaining quinone pseudopeptides via one-pot Ugi and sequential nucleophilic substitution (SN) methodology was developed. Compounds were evaluated for their antimicrobial and anticancer activities and their corresponding antioxidant/pro-oxidant profiles were assesed employing 2,2-diphenyl-1-picrylhydrazyl (DPPH), bleomycin dependent DNA damage and glutathione peroxidase (GPx)-like activity assays. Selenium based quinones were among the most potent cytotoxic compounds with a slight preference for MCF-7 compared to HepG2 cells and good free radical scavenging activity...
2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/26301125/assesment-of-conjunctival-microangiopathy-in-a-patient-with-diabetes-mellitus-using-the-retinal-function-imager
#18
Nicole Stuebiger, William Smiddy, Jianhua Wang, Hong Jiang, Delia Cabrera DeBuc
Diabetes mellitus (DM) is notorious for causing retinal microangiopathy, but bulbar conjunctival microangiopathy (CM) mirroring the established retinal vessel changes, has also been observed. Recent studies suggest that CM occurs in all DM patients in various degrees depending on disease severity and occur even before non-proliferative retinopathy develops. Thus, CM might provide a means of early detection or even form a basis for early intervention of disease progression in DM patients. Herein we present - to our knowledge for the first time-the feasibility and applicability in diagnostic imaging of CM in a diabetic patient using a commercially available Retinal Function Imager (RFI, Optical Imaging Ltd, Rehovot, Israel)...
February 2015: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/26266195/assesment-of-heart-rate-variability-as-a-measure-of-cardiac-autonomic-status-in-psychiatric-patients-exposed-to-chemical-irritants
#19
Priyanka Srivastava, Supriya Gupta, Rajesh Rastogi, Manushree Gupta
BACKGROUND AND PURPOSE: However, little is known about the cardiac autonomic activity due to chemicals in psychiatric patients. Therefore, the objective of this study was to assess the effect of chemical irritants on the ANS of the person and measure that in the form of Heart Rate Variability (HRV), a noninvasive method to estimate the cardiac autonomic activity. The autonomic nervous system can significantly compromised by use of chemical irritants. MATERIALS AND METHODS: A cross-sectional hospital based study was conducted in which 33 patients (mean age: 29...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26195900/comparative-clinical-efficacy-of-ashtangavaleha-and-vyaghreehareetakee-avaleha-on-tamaka-shwasa-bronchial-asthma-in-children
#20
Arvind Kumar Dubey, S Rajagopala, Kalpana S Patel
BACKGROUND: Tamaka Shwasa is a chronic inflammatory condition of the lung airways resulting in episodic airflow obstruction. This disease is more predominant in children and aged population. Apart from being the leading cause of hospitalization for children, it is one of the most important chronic conditions causing elementary school absenteeism. The parallel disease entity in contemporary medical science to this disorder is Bronchial Asthma. AIM: This study was aimed to evaluate the clinical efficacy of Ashtangavaleha and Vyaghreehareetakee Avaleha on Tamaka Shwasa (Bronchial Asthma) in Children...
October 2014: Ayu
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