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Helicobater pylori

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https://www.readbyqxmd.com/read/26929759/efficacy-of-microencapsulated-lactic-acid-bacteria-in-helicobater-pylori-eradication-therapy
#1
Maha A Khalil, Mostafa M El-Sheekh, Hala I El-Adawi, Nehal M El-Deeb, Mohamed Z Hussein
BACKGROUND: Probiotic delivery systems are widely used nutraceutical products for the supplementation of natural intestinal flora. These delivery systems vary greatly in the effectiveness to exert health benefits for a patient. This study focuses on providing probiotic living cells with a physical barrier against adverse environmental conditions. MATERIALS AND METHODS: Microencapsulation of the selected lactic acid bacteria (LAB) using chitosan and alginate was performed...
October 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/26875899/high-dose-amoxicillin-based-first-line-regimen-is-equivalent-to-sequential-therapy-in-the-eradication-of-h-pylori-infection
#2
F Franceschi, V Ojetti, M Gabrielli, C Petruzziello, A Tortora, G Gasbarrini, L R Lopetuso, F Scaldaferri, A Gasbarrini
OBJECTIVE: Helicobater (H.) pylori eradication rates with standard first-line triple therapy have declined to unacceptable levels. To date, amoxicillin-resistant H. pylori strains have rarely been detected. Whether increasing the dosage of amoxicillin in a standard 7 days eradicating regimen may enhance its efficacy is not known. The aim of this paper is to compare the efficacy of a 7 days high-dose amoxicillin based first-line regimen with sequential therapy. PATIENTS AND METHODS: We have retrospectively analyzed data from 300 sex and age matched patients, who underwent 3 different therapeutic schemes: (1) standard LCA, lansoprazole 30 mg bid, clarithromycin 500 mg bid and amoxicillin 1000 mg bid for 7 days; (2) high dose LCA (HD-LCA), lansoprazole 30 mg bid, clarithromycin 500 mg bid and amoxicillin 1000 mg tid for 7 days; (3) sequential LACT, lansoprazole 30 mg bid plus amoxicillin 1000 mg bid for 5 days, followed by lansoprazole 30 mg bid, clarithromycin 500 mg bid and tinidazole 500 mg bid for 5 days...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/22691250/could-be-a-link-between-non-atopic-asthma-and-hp-infection
#3
M Pedullà, L Perrone, V Fierro, C Capristo, C Salpietro, S Leonardi, M La Rosa, T Arrigo, A Licari, P Longaretti, M Miraglia Del Giudice
A potential role of Helicobater Pylori (HP) infection in several extra-intestinal pathologies has been recently suggested. The aim of our study was to assess the role of serology positive for HP in atopic and non atopic infants and children affected by atopic dermatitis, urticaria, rhinitis and asthma. We included 615 children affected by atopic diseases. According to prick test positivity and age, we divided the patients into two groups: atopic or non-atopic patients and infants (0-2 years) or children (2-12 years)...
January 2012: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/22595727/gastric-cancer-carcinogenesis-and-tumor-progression
#4
Giovanni Corso, Raquel Seruca, Franco Roviello
BACKGROUND: Gastric cancer (GC) remains one of the leading causes of cancer-related deaths worldwide, even though a decline has been observed in its incidence and the mortality rate in recent decades. Gastric carcinogenesis is a complex phenomena involving multiple epigenetic and genetic factors; several genetic, environmental and infectious agents interact causing a cumulative effect in the early steps of gastric carcinogenesis. MATERIALS AND METHODS: The most commonly used classifications of GC are the World Health Organization (WHO) and the Laurén classifications which describes two main histological types, diffuse and intestinal, which have different clinicopathological characteristics...
May 2012: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/22558885/-update-helicobater-pylori-what-has-changed
#5
Wolfgang Fischbach
No abstract text is available yet for this article.
April 19, 2012: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/22486644/predicting-protein-protein-interactions-by-combing-various-sequence-derived-features-into-the-general-form-of-chou-s-pseudo-amino-acid-composition
#6
Xiao-Wei Zhao, Zhi-Qiang Ma, Ming-Hao Yin
Knowledge of protein-protein interactions (PPIs) plays an important role in constructing protein interaction networks and understanding the general machineries of biological systems. In this study, a new method is proposed to predict PPIs using a comprehensive set of 930 features based only on sequence information, these features measure the interactions between residues a certain distant apart in the protein sequences from different aspects. To achieve better performance, the principal component analysis (PCA) is first employed to obtain an optimized feature subset...
May 2012: Protein and Peptide Letters
https://www.readbyqxmd.com/read/22442977/-analysis-of-helicobacter-pylori-infection-prevalence-in-children-in-the-contemporary-period
#7
A V Svarval', R S Ferman, A B Zhebrun
AIM: Study of prevalence of Helicobacter pylori infection in one organized children community of St. Petersburg in the current period. MATERIALS AND METHODS: 390 children and adolescents of one of the general education schools of St. Petersburg were examined. Presence in blood sera of IgG to bacterial antigen of H. pylori and IgG to its CagA toxin by ELISA method was studied. In 222 children feces samples were studied. Determination of presence of H. pylori antigen in the feces was carried out by using Helicobacter pylori antigen ELISA Kit, Immundiagnostik test system...
January 2012: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
https://www.readbyqxmd.com/read/22428879/optimal-cutoff-value-of-the-serum-pepsinogen-level-for-prediction-of-gastric-cancer-incidence-the-hisayama-study
#8
Kentaro Shikata, Toshiharu Ninomiya, Koji Yonemoto, Fumie Ikeda, Jun Hata, Yasufumi Doi, Masayo Fukuhara, Takayuki Matsumoto, Mitsuo Iida, Takanari Kitazono, Yutaka Kiyohara
BACKGROUND: Serum pepsinogen (sPG) levels have been established as a good marker of chronic atrophic gastritis and the sequential occurrence of gastric cancer. However, there have been few prospective investigations which investigated the predictive performance of sPG for future gastric cancer incidence. SUBJECTS AND METHODS: We prospectively followed-up a total of 2446 community-dwelling Japanese aged ≥ 40 years for 10 years and used the Youden's index to determine the cutoff values of the pepsinogen I level and pepsinogen I/II ratio to accurately discriminate gastric cancer events...
June 2012: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/21933136/predicting-protein-protein-interactions-by-combing-various-sequence-derived
#9
Xiao-Wei Zhao, Zhi-Qiang Ma, Ming-Hao Yin
Knowledge of protein-protein interactions (PPIs) plays an important role in constructing protein interaction networks and understanding the general machineries of biological systems. In this study, a new method is proposed to predict PPIs using a comprehensive set of 930 features based only on sequence information, these features measure the interactions between residues a certain distant apart in the protein sequences from different aspects. To achieve better performance, the principal component analysis (PCA) is first employed to obtain an optimized feature subset...
September 20, 2011: Protein and Peptide Letters
https://www.readbyqxmd.com/read/21913398/-prevalence-of-helicobater-pylori-infection-among-population-of-northwestern-federal-district-of-russian-federation
#10
A V Svarval', R S Ferman, A B Zhebrun
AIM: Studies of Helicobater pylori infection rate among population of North-western federal district including St. Petersburg in 2007 - 2009. MATERIALS AND METHODS: 1021 individuals with various digestive tract pathologies as well as healthy individuals and blood donors were examined. 378 children and adolescents up to 19 years of age, and 643 adults 20 - 80 years of age were among the examined individuals. IgG to H. pylori complex antigen and IgG to its CagA toxin were determined in blood sera...
July 2011: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
https://www.readbyqxmd.com/read/21745241/review-article-non-bismuth-quadruple-concomitant-therapy-for-eradication-of-helicobater-pylori
#11
REVIEW
J P Gisbert, X Calvet
BACKGROUND: Traditional standard triple therapy for Helicobacter pylori infection (PPI-clarithromycin-amoxicillin) can easily be converted to non-bismuth quadruple (concomitant) therapy by the addition of a nitroimidazole twice daily. AIM: To critically review evidence on the role of non-bismuth quadruple therapy (PPI-clarithromycin-amoxicillin-nitroimidazole) in the treatment of H. pylori infection. METHODS: Bibliographical searches were performed in MEDLINE and relevant congresses...
September 2011: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/20205606/the-sequential-therapy-regimen-for-helicobacter-pylori-eradication
#12
REVIEW
Javier P Gisbert, Xavier Calvet, J P Anthony O'Connor, Francis Mégraud, Colm A O'Morain
IMPORTANCE OF THE FIELD: Standard triple therapy (STT) is the most used treatment for Helicobater pylori infection. The prevalence of antibiotic resistance has increased substantially in recent years and there has been a corresponding decrease in efficacy. AREAS COVERED IN THIS REVIEW: Bibliographical searches were performed in MEDLINE and international congresses up to 2009 for 'Helicobacter pylori' AND 'sequential regimen/therapy'. WHAT THE READER WILL GAIN: Several meta-analyses have demonstrated that sequential therapy (SQT) is more effective than STT...
April 2010: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/20082702/expression-and-display-of-urea-of-helicobacter-acinonychis-on-the-surface-of-bacillus-subtilis-spores
#13
Krzysztof Hinc, Rachele Isticato, Marcin Dembek, Joanna Karczewska, Adam Iwanicki, Grazyna Peszyńska-Sularz, Maurilio De Felice, Michał Obuchowski, Ezio Ricca
BACKGROUND: The bacterial endospore (spore) has recently been proposed as a new surface display system. Antigens and enzymes have been successfully exposed on the surface layers of the Bacillus subtilis spore, but only in a few cases the efficiency of expression and the effective surface display and have been determined. We used this heterologous expression system to produce the A subunit of the urease of the animal pathogen Helicobater acinonychis. Ureases are multi-subunit enzymes with a central role in the virulence of various bacterial pathogens and necessary for colonization of the gastric mucosa by the human pathogen H...
2010: Microbial Cell Factories
https://www.readbyqxmd.com/read/18988465/-cloning-expression-and-purification-of-helicobater-pylori-l-asparaginase
#14
Iu A Gladilina, N N Sokolov, Iu V Krasotkina
Asparaginase from Helicobacterpylori has been cloned and expressed in E. coli cells. Optimization of culturing and expression conditions allowed achieving stable synthesis of catalytically active asparaginase amounting up to 6% of total bacterial protein. A method developed for enzyme purification included a single chromatographic stage and provided more than sixty percent yield of homogeneous asparaginase. Specific asparaginase and glutaminase activities were estimated to 92 and 8,3 x 10(-3) ME/mg respectively...
July 2008: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/18473407/is-a-7-day-helicobater-pylori-treatment-enough-for-eradication-and-inactivation-of-gastric-inflammatory-activity
#15
RANDOMIZED CONTROLLED TRIAL
Carlos Robles-Jara, Carlos Robles-Medranda, Manuel Moncayo, Byron Landivar, Johnny Parrales
AIM: To compare the efficacy of a 7-d vs 10-d triple therapy regarding H pylori eradication, endoscopic findings and histological gastric inflammatory inactivation in the Ecuadorian population. METHODS: 136 patients with dyspepsia and H pylori infection were randomized in 2 groups (68 per group): group 1, 7-d therapy; group 2, 10-d therapy. Both groups received the same medication and daily dosage: omeprazole 20 mg bid, clarithromycin 500 mg bid and amoxicillin 1 g bid...
May 14, 2008: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/18402225/-third-mexican-consensus-on-helicobater-pylori
#16
EDITORIAL
Francisco Javier Bosques-Padilla
No abstract text is available yet for this article.
July 2007: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/18288244/identification-of-proteins-related-to-nickel-homeostasis-in-helicobater-pylori-by-immobilized-metal-affinity-chromatography-and-two-dimensional-gel-electrophoresis
#17
Xuesong Sun, Ruiguang Ge, Jen-Fu Chiu, Hongzhe Sun, Qing-Yu He
Helicobacter pylori (H. pylori) is a widespread human pathogen causing peptic ulcers and chronic gastritis. Maintaining nickel homeostasis is crucial for the establishment of H. pylori infection in humans. We used immobilized-nickel affinity chromatography to isolate Ni-related proteins from H. pylori cell extracts. Two-dimensional gel electrophoresis and mass spectrometry were employed to separate and identify twenty two Ni-interacting proteins in H. pylori. These Ni-interacting proteins can be classified into several general functional categories, including cellular processes (HspA, HspB, TsaA, and NapA), enzymes (Urease, Fumarase, GuaB, Cad, PPase, and DmpI), membrane-associated proteins (OM jhp1427 and HpaA), iron storage protein (Pfr), and hypothetical proteins (HP0271, HP jhp0216, HP jhp0301, HP0721, HP0614, and HP jhp0118)...
2008: Metal-based Drugs
https://www.readbyqxmd.com/read/18159161/-histological-changes-of-gastric-atrophy-and-intestinal-metaplasia-after-helicobacter-pylori-eradication
#18
Yonggu Lee, Yong Cheol Jeon, Tai Yeon Koo, Hyun Seok Cho, Tae Jun Byun, Tae Yeob Kim, Hang Lak Lee, Chang Soo Eun, Oh Young Lee, Dong Soo Han, Joo Hyun Sohn, Byung Chul Yoon
BACKGROUND/AIMS: Long-term Helicobater pylori infection results in atrophic gastritis and intestinal metaplasia, and increases the risk of gastric cancer. However, it is still controversial that eradication of H. pylori improves atrophy or metaplasia. Therefore, we investigated histological changes after the H. pylori eradication in patients with atrophy or metaplasia. METHODS: One hundred seven patients who received successful eradication of H. pylori infection in Hanyang University, Guri Hospital from March 2001 to April 2006, were enrolled...
November 2007: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/15743355/evidence-that-loss-of-sonic-hedgehog-is-an-indicator-of-helicobater-pylori-induced-atrophic-gastritis-progressing-to-gastric-cancer
#19
Akiko Shiotani, Hiroyasu Iishi, Noriya Uedo, Shingo Ishiguro, Masaharu Tatsuta, Yukinori Nakae, Mitsutaka Kumamoto, Juanita L Merchant
BACKGROUND: The absence of sonic hedgehog (Shh) correlates with the development of intestinal metaplasia (IM) suggesting the possibility of an association between Shh expression and neoplastic transformation. AIM: To examine Shh expression in the noncancerous mucosa of patients with gastric cancer and compare it to Shh expression in Helicobater pylori-infected and uninfected controls. We also assessed the relationship between the type of IM and Shh expression. METHODS: Fifty-three patients with endoscopic mucosal resection (EMR) for early gastric cancer and 48 sex- and age-matched controls were studied...
March 2005: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/15554986/pathophysiology-of-gerd-in-china-the-same-factors-at-a-lower-scale
#20
EDITORIAL
Daniel Sifrim, Xin Zhang
Most of the factors involved in the pathogenesis of gastroesophageal reflux disease (GERD), previously described in European, Australian, and American studies, are present in Chinese patients with GERD, but at a lower scale. The acidity of gastric contents is reduced either spontaneously or by Helicobater pylori infection. A low-fat diet probably contributes to a more favorable gastric distribution of the meals, reduced obesity, and lowers the number of TLESRs. The prevalence of hiatal hernia is low and esophageal motility disorders are moderate...
November 2004: American Journal of Gastroenterology
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