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https://www.readbyqxmd.com/read/29145277/tricho-hepato-enteric-syndrome-with-novel-skiv2l-gene-mutations-a-case-report
#1
Eitaro Hiejima, Takahiro Yasumi, Hiroshi Nakase, Minoru Matsuura, Yusuke Honzawa, Hirokazu Higuchi, Ikuo Okafuji, Tohru Yorifuji, Takayuki Tanaka, Kazushi Izawa, Tomoki Kawai, Ryuta Nishikomori, Toshio Heike
RATIONALE: Tricho-hepato-enteric syndrome (THES) is a rare disorder caused by mutations in the TTC37 or SKIV2L genes and characterized by chronic diarrhea, liver disease, hair abnormalities, and high mortality in early childhood due to severe infection or liver cirrhosis. PATIENT CONCERNS: The patient is the second child of three siblings born to non-consanguineous healthy Japanese parents. She had intrauterine growth retardation and was delivered at 33 weeks of gestation due to placental abruption...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29141346/-etiologic-characteristics-of-shigella-sonnei-strains-isolated-from-some-areas-of-guangdong-province-and-guangxi-zhuang-autonomous-region-of-china-2014-2016
#2
B S Li, L J Chen, B X Ke, J M Lin, L Q Xu, H L Tan, D M He, Y H Liang, C W Ke, Y H Zhang
Objective: To investigated the etiologic characteristics of Shigella (S.) sonnei strains causing outbreaks and sporadic cases in some areas of Guangdong province and Guangxi Zhuang Autonomous Region during 2014-2016. Methods: Fourteen S. sonnei strains isolated from outbreaks and 6 S. sonnei strains from sporadic cases from Guangdong and Liuzhou of Guangxi Zhuang Autonomous Region were tested for antimicrobial resistance and analyzed by pulsed-field gel electrophoresis (PFGE). Six typical strains were selected for whole genome sequencing typing and compared with 51 strains isolated both at home and abroad from NCBI genome database...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29138886/clinical-predictors-of-stenotrophomonas-maltophilia-bacteremia-in-adult-patients-with-hematologic-malignancy
#3
Si-Ho Kim, Sun Young Cho, Cheol-In Kang, Hyeri Seok, Kyungmin Huh, Young Eun Ha, Doo Ryeon Chung, Nam Yong Lee, Kyong Ran Peck, Jae-Hoon Song
Stenotrophomonas maltophilia (SM) has emerged as an important nosocomial pathogen with high morbidity and mortality. Because of its unique antimicrobial susceptibility pattern, appropriate antimicrobial therapy for SM bacteremia is still challenging, especially in immunocompromised patients. The present study was performed to assess clinical predictors of SM bacteremia in adult patients with hematologic malignancy. From 2006 through 2016, a case-control study was performed at a tertiary-care hospital. Case patients were defined as SM bacteremia in patients with hematologic malignancy...
November 14, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29136156/increase-in-antimicrobial-resistance-and-emergence-of-major-international-high-risk-clonal-lineages-in-dogs-and-cats-with-urinary-tract-infection-16-year-retrospective-study
#4
Cátia Marques, Adriana Belas, Andreia Franco, Catarina Aboim, Luís Telo Gama, Constança Pomba
Objectives: To evaluate temporal trends in antimicrobial resistance, over 16 years, in bacteria isolated from dogs and cats with urinary tract infection (UTI) and the clonal lineages of bacteria harbouring critical antimicrobial resistance mechanisms. Methods: Antimicrobial susceptibility testing was conducted for 948 bacteria isolated from dogs and cats with UTI (1999-2014). Resistance mechanisms were detected by PCR, namely ESBL/AmpC in third-generation cephalosporin (3GC)-resistant Escherichia coli and Proteus mirabilis, mecA in methicillin-resistant staphylococci, and aac(6')-Ieaph(2″)-Ia and aph(2″)-1d in high-level gentamicin-resistant (HLGR) enterococci...
November 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29135400/-the-comparison-of-microscopy-and-real-time-polymerase-chain-reaction-methods-for-the-diagnosis-of-pneumocystis-jirovecii-pneumonia-evaluation-of-clinical-parameters
#5
Seray Töz, Cumhur Gündüz, Aslı Tetik, Meltem Taşbakan, Hüsnü Pullukçu, Feza Bacakoğlu, Mehmet Sezai Taşbakan, Figen Gülen, Ayşegül Ünver, Nevin Turgay
Introduction: Pneumocystis jirovecii pneumonia (PCP) causes serious infections, especially in patients with immunosuppressive diseases. In this study, it was aimed to evaluate the results of samples obtained from PCP suspected patients using two different methods together with clinical data. Materials and Methods: Microscopy and real time polymerase chain reaction (real time PCR) methods were performed with bronchoalveolar lavage (BAL) samples sended to Ege University Medical Faculty Direct Parasitology Diagnostic Laboratory between March 2009 and June 2010...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29127212/cephalexin-plus-trimethoprim-sulfamethoxazole-was-not-superior-to-cephalexin-alone-for-the-treatment-of-outpatient-non-purulent-cellulitis
#6
REVIEW
Loren G Miller
No abstract text is available yet for this article.
November 10, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/29121838/possible-trimethoprim-sulfamethoxazole-induced-hemolytic-anemia-a-case-report
#7
Montgomery F Williams, Emily P Doss, Maggie Montgomery
OBJECTIVE: To report a case of hemolytic anemia in a patient who received trimethoprim/sulfamethoxazole (TMP-SMX) for a urinary tract infection (UTI). SUMMARY: A 47-year-old woman recently diagnosed with uncomplicated UTI received 3 doses of TMP-SMX. She developed yellowing of the skin and eyes, lethargy, mild abdominal pain, and dry mucous membranes. Laboratory testing demonstrated significant anemia with red blood cells (RBCs) of 1.99, hemoglobin (Hgb) of 6.3 g/dL, and hematocrit (Hct) of 18...
December 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29120560/klebsiella-pneumoniae-oxa-48-in-a-urology-patient-case-report
#8
Ines Jajić, Ana Benčić, Marko Siroglavić, Gernot Zarfel, Boris Ružić, Ivan Pezelj, Branka Bedenić
We present an isolate of Klebsiella pneumoniae OXA-48 isolated in a 68-year-old man who underwent radical prostatectomy due to prostate cancer. The antibiotic susceptibility testing to a wide range of antibiotics was performed by disk diffusion method and determination of minimal inhibitory concentrations. The isolate was classified as multidrug-resistant. It showed intermediate susceptibility to imipenem and meropenem, resistance to ertapenem, and sensitivity only to colistin, amikacin, and trimethoprim-sulfamethoxazole...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29118939/escherichia-coli-pathotypes-and-shigella-sero-groups-in-diarrheic-children-in-nairobi-city-kenya
#9
Peter Lokamar Nyanga, Jackson Onyuka, Mark Kilongosi Webale, Tom Were, Valentine Budambula
Aim: In the present study, we investigated the prevalence of E. coli pathotypes and Shigella sero-groups and their antimicrobial profiles among diarrheic children in Nairobi city, Kenya. Background: Although diarrheagenic E. coli pathotypes and Shigella sero-groups are leading causes of diarrhea in children under five years in developing countries, their distribution and antimicrobial resistance vary from place to place and over time in a given region. Methods: In a cross-sectional study, we enrolled diarrheic children (n=354) under five years seeking treatment at Mbagathi Hospital, Nairobi city, Kenya,...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29112974/impact-of-extensive-antibiotic-treatment-on-faecal-carriage-of-antibiotic-resistant-enterobacteria-in-children-in-a-low-resistance-prevalence-setting
#10
Per Kristian Knudsen, Petter Brandtzaeg, E Arne Høiby, Jon Bohlin, Ørjan Samuelsen, Martin Steinbakk, Tore G Abrahamsen, Fredrik Müller, Karianne Wiger Gammelsrud
We prospectively studied the consequences of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in a cohort of children with cystic fibrosis (CF) and a cohort of children with cancer compared to healthy children with no or low antibiotic exposure. The study was conducted in Norway in a low resistance prevalence setting. Sixty longitudinally collected faecal samples from children with CF (n = 32), 88 samples from children with cancer (n = 45) and 127 samples from healthy children (n = 70) were examined...
2017: PloS One
https://www.readbyqxmd.com/read/29112840/antibiotics-and-common-antibacterial-biocides-stimulate-horizontal-transfer-of-resistance-at-low-concentrations
#11
J Jutkina, N P Marathe, C-F Flach, D G J Larsson
There is a rising concern that antibiotics, and possibly other antimicrobial agents, can promote horizontal transfer of antibiotic resistance genes. For most types of antimicrobials their ability to induce conjugation below minimal inhibitory concentrations (MICs) is still unknown. Our aim was therefore to explore the potential of commonly used antibiotics and antibacterial biocides to induce horizontal transfer of antibiotic resistance. Effects of a wide range of sub-MIC concentrations of the antibiotics cefotaxime, ciprofloxacin, gentamicin, erythromycin, sulfamethoxazole, trimethoprim and the antibacterial biocides chlorhexidine digluconate, hexadecyltrimethylammoniumchloride and triclosan were investigated using a previously optimized culture-based assay with a complex bacterial community as a donor of mobile resistance elements and a traceable Escherichia coli strain as a recipient...
November 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29110404/antimicrobial-resistance-trends-in-escherichia-coli-isolated-from-diseased-food-producing-animals-in-france-a-14-year-period-time-series-study
#12
C Boireau, É Morignat, G Cazeau, N Jarrige, É Jouy, M Haenni, J-Y Madec, A Leblond, É Gay
Antimicrobial resistance (AMR) among bacteria isolated from food-producing animals is a growing concern with implications for public health. AMR surveillance is essential to identify resistance trends and help in the design of effective and efficient control strategies. The aim of the study was to describe the antimicrobial susceptibility of pathogenic Escherichia coli isolated from three livestock productions in France (cattle, swine and poultry). The trend in resistance to the most commonly prescribed antibiotics in animal health was analysed as follows: amoxicillin (penicillin), spectinomycin or streptomycin (aminoglycoside), tetracycline and trimethoprim-sulfamethoxazole/Enrofloxacin and ceftiofur were also taken into account as members of critically important antimicrobial families in human and veterinary medicine, that is fluoroquinolones and third-generation cephalosporins, respectively...
November 7, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29109580/fosfomycin-susceptibility-in-multidrug-resistant-enterobacteriaceae-species-and-vancomycin-resistant-enterococci-urinary-isolates
#13
Linda B Ou, Lynn Nadeau
Background: Broad-spectrum antibiotics are often used to treat urinary tract infections (UTIs) due to drug-resistant species of Enterobacteriaceae and Enterococcus (e.g., organisms producing extended-spectrum β-lactamase [ESBL] or AmpC β-lactamase, as well as vancomycin-resistant enterococci [VRE]). However, this type of therapy can promote selection of resistant organisms and may necessitate venous access. Fosfomycin is an orally administered, single-dose antibiotic for the treatment of uncomplicated UTI...
September 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29106325/diarrheagenic-escherichia-coli-and-shigella-with-high-rate-of-extended-spectrum-beta-lactamase-production-two-predominant-etiological-agents-of-acute-diarrhea-in-shiraz-iran
#14
Maneli Aminshahidi, Amir Arastehfar, Gholamreza Pouladfar, Esmayil Arman, Fereshteh Fani
This study was conducted to find the etiology of acute diarrhea in Iranian children and determine the antimicrobial resistance patterns. The pathogenic bacteria were recovered from 110/269 (40.9%) diarrheal fecal samples with the following profiles: the most predominant pathogen was diarrheagenic Escherichia coli (DEC) (43.6%), comprising enteroaggregative E. coli (23.6%), enteropathogenic E. coli (10.9%), enteroinvasive E. coli (5.5%), and enterotoxigenic E. coli (3.6%); Shigella spp. (37.3%), Salmonella spp...
November 6, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29105868/successful-treatment-of-disseminated-nocardiosis-caused-by-nocardia-veterana-in-a-dog
#15
S Yaemsiri, J E Sykes
A 5-year-old male castrated Lhasa Apso cross was evaluated for a 1-month history of inappetence, lethargy, gagging, and progressive right thoracic limb lameness. Synovial fluid analysis revealed nonseptic suppurative inflammation, and a diagnosis of immune-mediated polyarthritis (IMPA) was made. After 3 months of treatment with prednisone and later cyclosporine, the dog developed multiple firm cutaneous and subcutaneous masses and a focal mass within the jejunum. Cultures of blood, urine, skin lesions, and the jejunal mass identified Nocardia veterana by matrix-absorption laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and allowed for earlier identification of the organism compared to more traditional secA1 gene sequencing...
November 4, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29105847/characterization-of-leptospira-species-isolated-from-soil-collected-in-japan
#16
Toshiyuki Masuzawa, Keiko Sakakibara, Mitsumasa Saito, Yusuke Hidaka, Sharon Y A M Villanueva, Yasutake Yanagihara, Shin-Ichi Yoshida
Leptospira was isolated from soil obtained from Hokkaido, the northernmost island, to Okinawa, the southernmost island, in Japan using sulfamethoxazole, trimethoprim, amphotericin B, fosfomycin, and 5- fluorouracil (STAFF). Fifty out of 132 soil samples (37.9%) were culture-positive. Based on 16S-rDNA sequences, 12 were classified into a pathogenic species clade and were closely associated with L. alstonii and L. kmetyi. Nine isolates were classified into intermediate species, which were similar to L. licerasiae...
November 6, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29102867/advanced-oxidation-of-real-sulfamethoxazole%C3%A2-trimethoprim-formulations-using-different-anodes-and-electrolytes
#17
Juan C Murillo-Sierra, Ignasi Sirés, Enric Brillas, Edgar J Ruiz-Ruiz, Aracely Hernández-Ramírez
A commercial sulfamethoxazole + trimethoprim formulation has been degraded in 0.050 M Na2SO4 at pH 3.0 by electrochemical oxidation with electrogenerated H2O2 (EO-H2O2), electro-Fenton (EF), photoelectro-Fenton with a 6-W UVA lamp (PEF) and solar photoelectro-Fenton (SPEF). The tests were performed in an undivided cell with an IrO2-based, Pt or boron-doped diamond (BDD) anode and an air-diffusion cathode for H2O2 electrogeneration. The anode material had little effect on the accumulated H2O2 concentration...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29100638/presence-concentrations-and-risk-assessment-of-selected-antibiotic-residues-in-sediments-and-near-bottom-waters-collected-from-the-polish-coastal-zone-in-the-southern-baltic-sea-summary-of-3years-of-studies
#18
Grzegorz Siedlewicz, Anna Białk-Bielińska, Marta Borecka, Aleksandra Winogradow, Piotr Stepnowski, Ksenia Pazdro
Concentrations of selected antibiotic compounds from different groups were measured in sediment samples (14 analytes) and in near-bottom water samples (12 analytes) collected in 2011-2013 from the southern Baltic Sea (Polish coastal zone). Antibiotics were determined at concentration levels of a few to hundreds of ng g(-1) d.w. in sediments and ng L(-1) in near-bottom waters. The most frequently detected compounds were sulfamethoxazole, trimethoprim, oxytetracycline in sediments and sulfamethoxazole and trimethoprim in near-bottom waters...
October 31, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29093385/a-case-of-pneumocystis-pneumonia-secondary-to-idiopathic-cd4-t-lymphocytopenia-a-comparison-of-aids-and-non-aids-patients
#19
Kazuki Sone, Hideki Muramatsu, Makoto Nakao, Yusuke Kagawa, Ryota Kurokawa, Hidefumi Sato, Akio Niimi
A 67-year-old man was admitted to our hospital complaining of dry cough. Chest computed tomography showed diffuse infiltrates and ground-glass opacities in the bilateral lung fields. Transbronchial lung biopsy specimens showed alveoli filled with yeast-like fungi. With a diagnosis of pneumocystis pneumonia (PCP), he was given oral sulfamethoxazole/trimethoprim, to which he responded well. However, seven months later, PCP relapsed. Analyses revealed a low bronchoalveolar lavage fluid CD4/CD8 ratio of 0.04 and CD4+ lymphocytopenia (250/μL)...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29092853/prophylactic-effect-of-trimethoprim-sulfamethoxazole-for-pneumocystis-pneumonia-in-patients-with-rheumatic-diseases-exposed-to-prolonged-high-dose-glucocorticoids
#20
Jun Won Park, Jeffrey R Curtis, Jinyoung Moon, Yeong Wook Song, Suhnggwon Kim, Eun Bong Lee
OBJECTIVES: To investigate the efficacy and safety of trimethoprim/sulfamethoxazole (TMP-SMX) as primary prophylaxis for pneumocystis pneumonia (PCP) in patients with rheumatic diseases receiving high-dose steroids. METHODS: The study included 1522 treatment episodes with prolonged (≥4 weeks) high-dose (≥30 mg/day prednisone) steroids in 1092 patients over a 12-year period. Of these, 262 treatment episodes involved TMP-SMX (prophylaxis group) while other episodes involved no prophylaxis (control group)...
November 1, 2017: Annals of the Rheumatic Diseases
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