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https://www.readbyqxmd.com/read/28438000/development-of-limited-view-and-three-dimensional-reconstruction-method-for-analysis-of-electrohydrodynamic-jetting-behavior
#1
Yeonghyeon Gim, Dong Ho Shin, Do Yoon Moh, Han Seo Ko
For an electrohydrodynamic (EHD) jet, variables such as the direction of the meniscus and the ejection stability need to be analyzed. Thus, the EHD jet should be observed three-dimensionally (3D) because the variables can only be obtained in the 3D field, especially in unstable modes. However, if the 3D field is reconstructed from multi-directional binary images, eliminating reconstruction errors caused by invisible areas is almost impossible, even when using a tomographic technique. To solve this problem, a new 3D reconstruction method including an ellipse estimation was developed in this study...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437993/integrated-optical-force-sensors-using-focusing-photonic-crystal-arrays
#2
Jingkun Guo, Richard A Norte, S Gröblacher
Mechanical oscillators are at the heart of many sensor applications. Recently several groups have developed oscillators that are probed optically, fabricated from high-stress silicon nitride films. They exhibit outstanding force sensitivities of a few aN/Hz<sup>1/2</sup> and can also be made highly reflective, for efficient detection. The optical read-out usually requires complex experimental setups, including positioning stages and bulky cavities, making them impractical for real applications. In this paper we propose a novel way of building fully integrated all-optical force sensors based on low-loss silicon nitride mechanical resonators with a photonic crystal reflector...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437764/the-use-of-lithium-for-the-treatment-of-bipolar-disorder-recommendations-from-clinical-practice-guidelines
#3
Gin S Malhi, Danielle Gessler, Tim Outhred
BACKGROUND: Lithium is an effective mood stabilizer that is used principally for the management of bipolar disorder (BD). Its administration is complex and often requires sophisticated management and assiduous monitoring. When considering the use of lithium therapy for bipolar disorder, clinicians are advised to refer to recommendations outlined in clinical practice guidelines (CPGs); but because of varying emphases placed by different international CPGs, recommendations addressing the practical use of lithium lack consistency...
March 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28437639/a-novel-biosensor-based-on-boronic-acid-functionalized-metal-organic-frameworks-for-the-determination-of-hydrogen-peroxide-released-from-living-cells
#4
Hongxia Dai, Wenjuan Lü, Xianwei Zuo, Qian Zhu, Congjie Pan, Xiaoying Niu, Juanjuan Liu, HongLi Chen, Xingguo Chen
In this work, we report a durable and sensitive H2O2 biosensor based on boronic acid functionalized metal-organic frameworks (denoted as MIL-100(Cr)-B) as an efficient immobilization matrix of horseradish peroxidase (HRP). MIL-100(Cr)-B features a hierarchical porous structure, extremely high surface area, and sufficient recognition sites, which can significantly increase HRP loading and prevent them from leakage and deactivation. The H2O2 biosensor can be easily achieved without any complex processing. Meanwhile, the immobilized HRP exhibited enhanced stability and remarkable catalytic activity towards H2O2 reduction...
April 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28437103/ion-pair-oligomerization-of-chromogenic-triangulenium-cations-with-cyanostar-modified-anions-that-controls-emission-in-hierarchical-materials
#5
Bo Qiao, Brandon E Hirsch, Semin Lee, Maren Pink, Chun-Hsing Chen, Bo W Laursen, Amar H Flood
The hierarchical assembly of colored cationic molecules with receptor-modified counteranions can be used to control optical properties in materials. However, our knowledge of when the optical properties emerge in the hierarchical organization and the variety of cation-anion salts that are available to create these materials is limited. In this work, we extend the salts from small halides to large inorganic anions and determine how the structure coevolves with the emission properties using solution assemblies...
April 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28437064/rapid-and-highly-sensitive-detection-of-dopamine-using-conjugated-oxaborole-based-polymer-and-glycopolymer-systems
#6
Keren Jiang, Yinan Wang, Garima Thakur, Yohei Kotsuchibashi, Selvaraj Naicker, Ravin Narain, Thomas Thundat
A conjugated polymer interface consisting of an oxaborole containing polymer and a glycopolymer was used for achieving very high selectivity in dopamine (DA) detection. The optimum binding affinity between the polymers promotes the selectivity to DA through a displacement mechanism while remaining unaffected by other structurally related analogs and saccharide derivatives. Real-time detection of DA with very high selectivity and sensitivity has been demonstrated by immobilizing the polymer conjugates on surface plasmon resonance (SPR) and microcantilever (MCL) sensor platforms...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28436960/amyloid-fibril-systems-reduce-stabilize-and-deliver-bioavailable-nanosized-iron
#7
Yi Shen, Lidija Posavec, Sreenath Bolisetty, Florentine M Hilty, Gustav Nyström, Joachim Kohlbrecher, Monika Hilbe, Antonella Rossi, Jeannine Baumgartner, Michael B Zimmermann, Raffaele Mezzenga
Iron-deficiency anaemia (IDA) is a major global public health problem. A sustainable and cost-effective strategy to reduce IDA is iron fortification of foods, but the most bioavailable fortificants cause adverse organoleptic changes in foods. Iron nanoparticles are a promising solution in food matrices, although their tendency to oxidize and rapidly aggregate in solution severely limits their use in fortification. Amyloid fibrils are protein aggregates initially known for their association with neurodegenerative disorders, but recently described in the context of biological functions in living organisms and emerging as unique biomaterial building blocks...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28436657/role-of-humic-acid-in-the-stability-of-ag-nanoparticles-in-sub-oxic-conditions
#8
Christopher J Milne, Dan J Lapworth, Daren C Gooddy, Christine N Elgy, Eugenia Valsami-Jones
Stability and temporal changes in size distributions have been observed for citrate- and polyvinylpyrrolidone- (PVP) capped silver nanoparticles (AgNPs), in the presence or absence of sulfide and natural organic matter (NOM - as humic acid), whilst under sub-oxic conditions. There were substantial differences in the influence of the two capping agents, with PVP-AgNPs showing few or no significant changes in apparent stability or particle size distribution under the conditions examined, whilst the apparent size distributions of citrate-capped AgNPs changed rapidly...
April 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28436600/high-performance-integrated-self-package-flexible-li-o2-battery-based-on-stable-composite-anode-and-flexible-gas-diffusion-layer
#9
Xiao-Yang Yang, Ji-Jing Xu, Di Bao, Zhi-Wen Chang, Da-Peng Liu, Yu Zhang, Xin-Bo Zhang
With the rising development of flexible and wearable electronics, corresponding flexible energy storage devices with high energy density are required to provide a sustainable energy supply. Theoretically, rechargeable flexible Li-O2 batteries can provide high specific energy density; however, there are only a few reports on the construction of flexible Li-O2 batteries. Conventional flexible Li-O2 batteries possess a loose battery structure, which prevents flexibility and stability. The low mechanical strength of the gas diffusion layer and anode also lead to a flexible Li-O2 battery with poor mechanical properties...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28435892/dramatic-improvement-of-crispr-cas9-editing-in-candida-albicans-by-increased-single-guide-rna-expression
#10
Henry Ng, Neta Dean
The clustered regularly interspaced short palindromic repeat system with CRISPR-associated protein 9 nuclease (CRISPR/Cas9) has emerged as a versatile tool for genome editing in Candida albicans. Mounting evidence from other model systems suggests that the intracellular levels of single guide RNA (sgRNA) limit the efficiency of Cas9-dependent DNA cleavage. Here, we tested this idea and describe a new means of sgRNA delivery that improves previously described methods by ~10-fold. The efficiency of Cas9/sgRNA-dependent cleavage and repair of a single-copy yeast enhanced monomeric red fluorescent protein (RFP) gene was measured as a function of various parameters that are hypothesized to affect sgRNA accumulation, including transcriptional and posttranscriptional processing...
March 2017: MSphere
https://www.readbyqxmd.com/read/28435866/layered-microporous-polymers-by-solvent-knitting-method
#11
Shaolei Wang, Chengxin Zhang, Yu Shu, Shulan Jiang, Qi Xia, Linjiang Chen, Shangbin Jin, Irshad Hussain, Andrew I Cooper, Bien Tan
Two-dimensional (2D) nanomaterials, especially 2D organic nanomaterials with unprecedentedly diverse and controlled structure, have attracted decent scientific interest. Among the preparation strategies, the top-down approach is one of the considered low-cost and scalable strategies to obtain 2D organic nanomaterials. However, some factors of their layered counterparts limited the development and potential applications of 2D organic nanomaterials, such as type, stability, and strict synthetic conditions of layered counterparts...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28435148/plasma-mediated-protein-immobilisation-enhances-the-vascular-compatibility-of-polyurethane-with-tissue-matched-mechanical-properties
#12
Irina Kondyurina, Steven Wise, Alan Ngo, Elysse Filipe, Alexey Kondyurin, Anthony Weiss, Shisan Bao, Marcela Bilek
Polyurethanes are a diverse class of polymers, with independently tunable mechanical and biodegradation properties making them a versatile platform material for biomedical implants. Previous iterations have failed to adequately embody appropriate mechanical and biological properties, particularly for vascular medicine where strength, compliance and multifaceted biocompatibility are required. We have synthesized a new polyurethane formulation with finely tuned mechanical properties, combining high strength and extensibility with a low Young's modulus...
April 24, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28434688/stability-of-heat-stable-live-attenuated-rotavirus-vaccine-rotasiil%C3%A2
#13
Sameer P Naik, Jagdish K Zade, Rajendra N Sabale, Sambhaji S Pisal, Ravi Menon, Subhash G Bankar, Sunil Gairola, Rajeev M Dhere
Vaccines currently available across the globe are stored and transported in a continuous cold-chain at 2-8°C or below -20°C. A temperature excursion outside this range affects the potency of the vaccines. Such vaccines need to be discarded leading wastage. The Rotavirus disease burden is predominantly reported in developing and low-income countries and therefore, has entered or poised to enter their national immunization programs. These countries already have several limitations for effective storage, maintenance and distribution of vaccines in a cold-chain and this introduction is expected to further stress this fragile ecosystem...
April 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28433858/reduced-graphene-oxide-chitosan-aptamer-interface-as-new-platform-for-ultrasensitive-detection-of-human-epidermal-growth-factor-receptor-2
#14
Arezoo Tabasi, Abdollah Noorbakhsh, Ensiyeh Sharifi
The present work describes an ultrasensitive electrochemical aptamer-based assay for detection of human epidermal growth factor receptor 2 protein (HER2) cancer biomarker as a model analyte. Results show that the reduced graphene oxide-chitosan (rGO-Chit) film as a suitable electrode material possesses great favorable properties including high homogeneity, good stability, large surface area and high fraction of amine groups as aptamer binding sites. Various steps of aptasensor fabrication were characterized using microscopic, energy-dispersive X-ray spectroscopy (EDAX), Fourier transform infrared (FTIR) spectroscopy and electrochemical techniques...
April 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28433837/internal-maxillary-bypass-for-complex-pediatric-aneurysms
#15
Long Wang, Shuaibin Lu, Hai Qian, Xiang'en Shi
BACKGROUND: Complex pediatric aneurysms (PAs) are an unusual clinicopathologic entity, and data remain limited regarding the use of a bypass procedure to treat this formidable disorder. METHODS: Internal maxillary artery (IMA) to middle cerebral artery (MCA) bypass with radial artery graft (RAG) was utilized to isolate PAs. Bypass patency and aneurysm stability were evaluated using intraoperative Doppler ultrasound, indocyanine green videoangiography and postoperative angiography...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28433531/discovery-and-optimization-of-selective-fgfr4-inhibitors-via-scaffold-hopping
#16
Yikai Wang, Zhengxia Chen, Meibi Dai, Peipei Sun, Chunqiu Wang, Yang Gao, Haixia Zhao, Wenqin Zeng, Liang Shen, Weifeng Mao, Tian Wang, Guoping Hu, Jian Li, Shuhui Chen, Chaofeng Long, Xiaoxin Chen, Junhua Liu, Yang Zhang
Introduction of a Michael acceptor on a flexible scaffold derived from pan-FGFR inhibitors has successfully yielded a novel series of highly potent FGFR4 inhibitors with selectivity over FGFR1. Due to reduced lipophilicity and aromatic ring count, this series demonstrated improved solubility and permeability. However, plasma instability and fast metabolism limited its potential for in vivo studies. Efforts have been made to address these problems, which led to the discovery of compound (-)-11 with improved stability, CYP inhibition, and good activity/selectivity for further optimization...
April 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28433529/antimicrobial-peptides-within-the-yellowtail-kingfish-seriola-lalandi
#17
Simon Muncaster, Kirsty Kraakman, Olivia Gibbons, Koen Mensink, Maria Forlenza, Gregory Jacobson, Steve Bird
A number of Seriola species are currently farmed or being investigated as future aquaculture species in countries around the world. However they face a number of issues and limitations which will need to be overcome to ensure future stability and growth, one of which are disease outbreaks. Despite this, very little has been done to understand the immune system of Seriola species and very few immune genes have been characterised. Antimicrobial peptides (AMP) are naturally occurring low molecular weight polypeptides that play a major role in an organism's immune system and act effectively as a first line of defence...
April 19, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28433327/replacing-antibodies-with-modified-dna-aptamers-in-vaccine-potency-assays
#18
Jeremiah J Trausch, Mary Shank-Retzlaff, Thorsten Verch
Vaccine in vitro potency assays are vital regulatory tests that are used to confirm the presence and concentration of an antigen of interest in a form that directly or indirectly relates to protective activity in patients. Current assays come in many forms, but they almost exclusively use antibody reagents for selective detection of the target antigen. Antibodies provide specific recognition of vaccine antigens but also exhibit drawbacks such as stability limitations, cost, and lot-to-lot variation, which can make it challenging to maintain the reagent throughout the lifetime of the vaccine...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28433172/preparation-and-characterization-of-chitosan-derivatives-and-their-application-as-flame-retardants-in-thermoplastic-polyurethane
#19
Xiaodong Liu, Xiaoyu Gu, Jun Sun, Sheng Zhang
Our previous work has demonstrated that chitosan (CS) can be directly used as charring agents. In this paper, efforts were made to further improve the thermal stability and charring ability of CS by reacting with benzaldehyde, salicylaldehyde and hydroxybenzaldehyde respectively to obtain different CS derivatives. CS derivatives in association with ammonium polyphosphate (APP) was then introduced into thermoplastic polyurethane (TPU) to prepare flame retardant TPU composites. The sample containing 18.75% APP and 6...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433154/non-immunogenic-porous-and-antibacterial-chitosan-and-antheraea-mylitta-silk-sericin-hydrogels-as-potential-dermal-substitute
#20
Sunaina Sapru, Ananta K Ghosh, Subhas C Kundu
Limitation of existing grafts including restricted donor site, risks of immune reactions, infectious diseases and high cost alarms the growing need of natural, cost effective and functional graft as the dermal substitute. We fabricate stable (>6 weeks) and porous (57.23-75.22μm) yet flexible (in variable pH) matrices using Antheraea mylitta sericin crosslinked with well known biocompatible polysaccharide chitosan by natural crosslinker (genipin) without using any harsh chemical. The fabricated matrices are characterized in terms of chemical modifications (Fourier transform infrared spectroscopy), crystallinity (X-ray diffraction), swelling, degradability and thermal stability...
July 1, 2017: Carbohydrate Polymers
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