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https://www.readbyqxmd.com/read/28644859/grief-interventions-for-people-bereaved-by-suicide-a-systematic-review
#1
Katja Linde, Julia Treml, Jana Steinig, Michaela Nagl, Anette Kersting
BACKGROUND: Adaption to the loss of a loved one due to suicide can be complicated by feelings of guilt, shame, responsibility, rejection, and stigmatization. Therefore people bereaved by suicide have an increased risk for developing complicated grief which is related to negative physical and mental disorders and an increased risk for suicidal behavior. Grief interventions are needed for this vulnerable population. The aim of this systematic review was to provide an overview of the current state of evidence concerning the effectiveness of interventions that focus on grief for people bereaved by suicide...
2017: PloS One
https://www.readbyqxmd.com/read/28644664/radiation-pressure-cooling-as-a-quantum-dynamical-process
#2
Bing He, Liu Yang, Qing Lin, Min Xiao
One of the most fundamental problems in optomechanical cooling is how small the thermal phonon number of a mechanical oscillator can be achieved under the radiation pressure of a proper cavity field. Different from previous theoretical predictions, which were based on an optomechanical system's time-independent steady states, we treat such cooling as a dynamical process of driving the mechanical oscillator from its initial thermal state, due to its thermal equilibrium with the environment, to a stabilized quantum state of higher purity...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644188/surgical-techniques-for-total-knee-arthroplasty-measured-resection-gap-balancing-and-hybrid
#3
Neil P Sheth, Adeel Husain, Charles Lenwood Nelson
Total knee arthroplasty (TKA) is effective in managing end-stage degenerative joint disease. Achieving favorable clinical outcomes is predicated on proper implant alignment, sizing, and rotation as well as adequate soft-tissue balancing. Modern TKA implants are designed to address the fundamental needs of attaining stability in both flexion and extension and of optimizing patellar tracking. Measured resection and gap balancing are the two different techniques used to implant the TKA components used today. Both techniques have been validated as durable and successful, and each has unique advantages and disadvantages...
July 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28644005/from-electrochemistry-to-electroluminescence-development-and-application-in-ratiometric-aptasensor-for-aflatoxin-b1
#4
Long Wu, Fan Ding, Wenmin Yin, Jing Ma, Biru Wang, Axiu Nie, Heyou Han
Aflatoxin B1 (AFB1), one of the most toxic chemical carcinogens, has been widely studied. It remains challenging to develop simple, accurate and sensitive analytical methods for the detection of AFB1 in food matrices. In this work, based on dual-signaling strategy, a ratiometric aptasensor was designed and verified for the accurate and sensitive detection of AFB1. The electrochemical method was first used as a model to verify the specific interaction between AFB1 and the aptamer, in which ferrocene (Fc) and methylene blue (MB) anchored DNA sequences were acted as dual signals...
June 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28643934/comprehensive-insights-into-the-thermal-stability-biodegradability-and-combustion-chemistry-of-pyrrolidinium-based-ionic-liquids
#5
Gebrekidan Gebreselassie Eshetu, Sangsik Jeong, Pascal Pandard, Amandine Lecocq, Guy Marlair, Stefano Passerini
The use of ionic liquids (ILs) as advanced electrolytes components in electrochemical energy storage devices is one of the most appealing and emerging options. However, though ILs are hailed as safer and eco-friendly electrolytes, overcoming the limitations imposed by the highly volatile/combustible carbonate based electrolytes, the full scale and precise appraisal of their overall safety levels under abuse conditions still need to be fully addressed. With the aim of providing the entreated level of information on the thermal and chemical stabilities as well as actual fire hazards, we embarked on a detailed investigation of the short - and long - term thermal stabilities, bio-degradability and combustion behaviour of various pyrrolidinium ([Pyr1A] +)-based ILs, enlisting different alkyl chain lengths, [Pyr1A] + (A=3-10), counter-anions ([TFSI]-/[FSI]-/[BETI]-), cations (Pyr14+/Pyr12O1+) and the effect of doping with Li salts (e...
June 23, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28643828/adaptability-of-the-metal-iii-iv-1-2-3-trioxobenzene-rod-secondary-building-unit-for-the-production-of-chemically-stable-and-catalytically-active-mofs
#6
Georges Mouchaham, Brian Abeykoon, Mónica Giménez-Marqués, Sergio Navalon, Andrea Santiago-Portillo, Maame Affram, Nathalie Guillou, Charlotte Martineau, Hermenegildo Garcia, Alexandra Fateeva, Thomas Devic
The use of a 5,10,15,20-tetrakis(3,4,5-trihydroxyphenyl)porphyrin has yielded a new MOF based on M-1,2,3-trioxobenzene chains that can be made of M = Zr(iv) or RE(iii) (RE = rare earth), showing a very high and limited chemical stability, respectively. The robust metallated Zr-analogue, Co-MIL-173(Zr), has proven to be a heme-like heterogeneous catalyst suitable for aerobic oxidation of hydrocarbons.
June 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28643776/ezrin-enhances-line-tension-along-transcellular-tunnel-edges-via-nmiia-driven-actomyosin-cable-formation
#7
Caroline Stefani, David Gonzalez-Rodriguez, Yosuke Senju, Anne Doye, Nadia Efimova, Sébastien Janel, Justine Lipuma, Meng Chen Tsai, Daniel Hamaoui, Madhavi P Maddugoda, Olivier Cochet-Escartin, Coline Prévost, Frank Lafont, Tatyana Svitkina, Pekka Lappalainen, Patricia Bassereau, Emmanuel Lemichez
Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. Cellular dewetting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit their widening. Here, by conducting high-resolution microscopy approaches we unveil the presence of an actomyosin cable encircling TEMs. We develop a theoretical cellular dewetting framework to interpret TEM physical parameters that are quantitatively determined by laser ablation experiments...
June 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28643471/molecular-self-assembly-fabrication-and-carrier-dynamics-of-stable-and-efficient-ch3nh3pb-1-x-snxi3-perovskite-solar-cells
#8
Jiandong Fan, Chong Liu, Hongliang Li, Cuilin Zhang, Wenze Li, Yaohua Mai
The Sn-based perovskite solar cells (PSCs) provide the possibility that swaps the Pb element toward toxic-free PSCs. Here, we innovatively employed a molecular self-assembly approach to obtain a series CH3NH3Pb(1-x)SnxI3 (0≤x≤1) perovskite thin films with full coverage. The optimized planar CH3NH3Pb0.75Sn0.25I3 PSCs with inverted structure was consequently realized with a maximum power conversion efficiency (PCE) over 14 %, which displayed a stabilized power output (SPO) over 12 % within 200 s at 0.6 V forward bias...
June 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28643300/-advantages-and-disadvantages-of-minimally-invasive-surgery-in-colorectal-cancer-surgery
#9
Minhua Zheng, Junjun Ma
Since the emergence of minimally invasive technology twenty years ago, as a surgical concept and surgical technique for colorectal cancer surgery, its obvious advantages have been recognized. Laparoscopic technology, as one of the most important technology platform, has got a lot of evidence-based support for the oncological safety and effectiveness in colorectal cancer surgery Laparoscopic technique has advantages in terms of identification of anatomic plane and autonomic nerve, protection of pelvic structure, and fine dissection of vessels...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28642608/ocean-acidification-as-a-driver-of-community-simplification-via-the-collapse-of-higher-order-and-rise-of-lower-order-consumers
#10
S Vizzini, B Martínez-Crego, C Andolina, A Massa-Gallucci, S D Connell, M C Gambi
Increasing oceanic uptake of CO2 is predicted to drive ecological change as both a resource (i.e. CO2 enrichment on primary producers) and stressor (i.e. lower pH on consumers). We use the natural ecological complexity of a CO2 vent (i.e. a seagrass system) to assess the potential validity of conceptual models developed from laboratory and mesocosm research. Our observations suggest that the stressor-effect of CO2 enrichment combined with its resource-effect drives simplified food web structure of lower trophic diversity and shorter length...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642345/evolution-of-nonspectral-rhodopsin-function-at-high-altitudes
#11
Gianni M Castiglione, Frances E Hauser, Brian S Liao, Nathan K Lujan, Alexander Van Nynatten, James M Morrow, Ryan K Schott, Nihar Bhattacharyya, Sarah Z Dungan, Belinda S W Chang
High-altitude environments present a range of biochemical and physiological challenges for organisms through decreases in oxygen, pressure, and temperature relative to lowland habitats. Protein-level adaptations to hypoxic high-altitude conditions have been identified in multiple terrestrial endotherms; however, comparable adaptations in aquatic ectotherms, such as fishes, have not been as extensively characterized. In enzyme proteins, cold adaptation is attained through functional trade-offs between stability and activity, often mediated by substitutions outside the active site...
June 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28642127/exploiting-sequence-and-stability-information-for-directing-nanobody-stability-engineering
#12
Patrick Kunz, Tilman Flock, Nicolas Soler, Moritz Zaiss, Cécile Vincke, Yann Sterckx, Damjana Kastelic, Serge Muyldermans, Jörg D Hoheisel
BACKGROUND: Variable domains of camelid heavy-chain antibodies, commonly named nanobodies, have high biotechnological potential. In view of their broad range of applications in research, diagnostics and therapy, engineering their stability is of particular interest. One important aspect is the improvement of thermostability, because it can have immediate effects on conformational stability, protease resistance and aggregation propensity of the protein. METHODS: We analyzed the sequences and thermostabilities of 78 purified nanobody binders...
June 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28641528/drug-design-synthesis-and-in-vitro-evaluation-of-substituted-benzofurans-as-hsp90-inhibitors
#13
Sundeep Kadasi, Thadeu E M M Costa, Neha Arukala, Mallika Toshakani, Chaitanya Duggineti, Sreekanth Thota, Sayan Dutta Gupta, Shiva Raj, Carmen Penido, Maria G Henriques, Nulgumnalli Manjunathaiah Raghavendra
BACKGROUND: Heat shock protein 90 is a molecular chaperone required for the stability and function of several client proteins that promote cancer cell growth and/or survival. Discovery of Hsp90 inhibitors has emerged as an attractive target of research in cancer therapeutics. Natural products like geldanamycin and radicicol are established Hsp90 inhibitors, but face limitations with toxicity and inactivity, by in vivo studies respectively. However, they lay the logical starting point for the design of novel synthetic or semi-synthetic congeners as Hsp90 inhibitors...
June 22, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28641483/good-performance-of-platinum-based-chemotherapy-for-high-grade-gastroenteropancreatic-and-unknown-primary-neuroendocrine-neoplasms
#14
Giovanni Brandi, Marco Paragona, Davide Campana, Nicole Brighi, Arrigo Bondi, Maria Abbondanza Pantaleo, Jody Corbelli, Maria Aurelia Barbera, Guido Biasco
To evaluate efficacy and safety of platinum and etoposide combination in the treatment of advanced gastroenteropancreatic (GEP) and unknown primary (CUP) neuroendocrine carcinomas (NEC), we analysed the records of 21 consecutive patients treated with this regimen from 1999 to 2012. Objective responses were obtained in 11 patients (52%) and disease stability (DS) in 5 (24%). Median progression-free survival (PFS) was 7 months (95% CI, 5.33-8.66). Median overall survival (OS) was 16 months (95% CI, 14.97-17...
June 22, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28641183/size-partitioning-and-mixing-behavior-of-trace-metals-and-dissolved-organic-matter-in-a-south-china-estuary
#15
Wenhao Wang, Min Chen, Laodong Guo, Wen-Xiong Wang
The Jiulong River estuary, located in the southeastern China, suffered from metal pollution due to industrial effluent releases. Mixing of effluent and estuarine water may have significantly affected the size distribution of trace metals and their environmental fate. In the present study, colloidal size distribution of organic matter and selected metals were quantified using asymmetric flow field-flow fractionation (AF4) and ICP-MS. We demonstrated a dominance of dissolved metals in the 1-10kDa fraction, and metals such as Cu, Zn, Ni, Co, Pb, Cd and Mn were mostly regulated by terrestrial fulvic acid...
June 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28641171/electromyographic-analysis-of-rotator-cuff-muscles-in-patients-with-rotator-cuff-tendinopathy-a-systematic-review
#16
REVIEW
Fábio Carlos Lucas de Oliveira, Laurent Julien Bouyer, Amanda L Ager, Jean-Sébastien Roy
The shoulder is inherently an unstable joint which heavily relies on the neuromuscular activation of the rotator cuff (RC) complex for stability during movement. Currently, there is no consensus regarding how the activity of RC muscles is affected among individuals with a RC tendinopathy (RCTe). This study reviewed the evidence of studies comparing the electromyographic (EMG) activity of any RC muscle of shoulders with a symptomatic RCTe to asymptomatic shoulders. Eight databases were searched. Data from 343 participants (201 symptomatic and 209 asymptomatic shoulders) were analyzed from 10 out of 402 included studies...
June 10, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28640758/consecutive-ultra-short-term-heart-rate-variability-to-track-dynamic-changes-in-autonomic-nervous-system-during-and-after-exercise
#17
Xiang Chen, Ruijie Yao, Gezhen Yin, Jin Li
OBJECTIVE: Quantitative measurement of the dynamic changes in autonomic nervous system (ANS) during and after exercise has great significance in clinical, sports training and other fields. A consecutive ultra-short-term (30 s, UST) heart rate variability (HRV) method was proposed to track the exercise-induced autonomic control of heart rate (HR). APPROACH: Twenty-three healthy young men participated in the study. The first four stages of the Modified Bruce Protocol (S0-S3) were performed...
June 22, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28640646/an-enzyme-linked-immunosorbent-assay-for-monoester-type-aconitic-alkaloids-and-its-application-in-the-pharmacokinetic-study-of-benzoylhypaconine-in-rats
#18
Can-Can Liu, Yun-Hui Xu, Shuai Yuan, Yu Xu, Mo-Li Hua
A new enzyme-linked immunosorbent assay (ELISA) method for quantitative determination of monoester-type aconitic alkaloids was developed. The antibodies derived from the immunogen of benzoylmesaconine (BM) could be electively affined to benzoylaconitine-type alkaloids with an ester bond (14-benzoyl-), especially to benzoylhypaconine (BH, 140.02% of cross-reactivity). The effective working range of BH was 1 ng/ml to 5 μg/ml; the lower limit of detection and the quantification were 0.35 and 0.97 ng/ml, respectively...
June 22, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28640637/designing-transmitter-ligands-that-mediate-energy-transfer-between-semiconductor-nanocrystals-and-molecules
#19
Zhiyuan Huang, Ming Lee Tang
Molecular control of energy transfer is an attractive proposition because it allows chemists to synthetically tweak various kinetic and thermodynamic factors. In this Perspective, we examine energy transfer between semiconductor nano-crystals (NCs) and π-conjugated molecules, focusing on the transmitter ligand at the organic-inorganic interface. Efficient transfer of triplet excitons across this interface allows photons to be directed for effective use of the entire solar spectrum. For example, a photon upconversion system composed of semiconductor NCs as sensitizers, bound organic ligands as transmitters, and molecular annihilators has the advantage of large, tunable absorption cross-sections across the visible and near infrared wavelengths...
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28640299/anchoring-groups-for-photocatalytic-water-oxidation-on-metal-oxide-surfaces
#20
Kelly L Materna, Robert H Crabtree, Gary W Brudvig
Surface anchoring groups are needed to attach molecular units to photoanodes for photocatalytic water oxidation. The anchoring group must be hydrolytically stable and oxidation resistant under a variety of pH conditions. They must sometimes be electrically conducting for efficient light-induced electron injection from a photosensitizer to a metal oxide, but other times not conducting for accumulation of oxidizing equivalents on a water-oxidation catalyst. Commonly used anchors such as carboxylic acids and phosphonic acids have limited stability in aqueous environments, leading to surface hydrolysis and loss of catalytic function...
June 22, 2017: Chemical Society Reviews
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