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https://www.readbyqxmd.com/read/28335365/antibacterial-properties-of-visible-light-responsive-carbon-containing-titanium-dioxide-photocatalytic-nanoparticles-against-anthrax
#1
Der-Shan Sun, Jyh-Hwa Kau, Hsin-Hsien Huang, Yao-Hsuan Tseng, Wen-Shiang Wu, Hsin-Hou Chang
The bactericidal activity of conventional titanium dioxide (TiO₂) photocatalyst is effective only on irradiation by ultraviolet light, which restricts the applications of TiO₂ for use in living environments. Recently, carbon-containing TiO₂ nanoparticles [TiO₂(C) NP] were found to be a visible-light-responsive photocatalyst (VLRP), which displayed significantly enhanced antibacterial properties under visible light illumination. However, whether TiO₂(C) NPs exert antibacterial properties against Bacillus anthracis remains elusive...
December 9, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335267/dna-based-enzyme-reactors-and-systems
#2
REVIEW
Veikko Linko, Sami Nummelin, Laura Aarnos, Kosti Tapio, J Jussi Toppari, Mauri A Kostiainen
During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning pivotal molecules, such as enzymes, with nanometer-level precision. This feature could be used in the fabrication of artificial biochemical machinery that is able to mimic the complex reactions found in living cells. Currently, DNA-enzyme hybrids can be used to control (multi-enzyme) cascade reactions and to regulate the enzyme functions and the reaction pathways...
July 27, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335209/dye-doped-fluorescent-silica-nanoparticles-for-live-cell-and-in-vivo-bioimaging
#3
REVIEW
Wen-Han Zhang, Xiao-Xiao Hu, Xiao-Bing Zhang
The need for novel design strategies for fluorescent nanomaterials to improve our understanding of biological activities at the molecular level is increasing rapidly. Dye-doped fluorescent silica nanoparticles (SiNPs) emerge with great potential for developing fluorescence imaging techniques as a novel and ideal platform for the monitoring of living cells and the whole body. Organic dye-containing fluorescent SiNPs exhibit many advantages: they have excellent biocompatibility, are non-toxic, highly hydrophilic, optically transparent, size-tunable and easily modified with various biomolecules...
April 27, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334808/downregulation-of-pathways-implicated-in-liver-inflammation-and-tumorigenesis-of-glycogen-storage-disease-type-ia-mice-receiving-gene-therapy
#4
Goo-Young Kim, Joon Hyun Kwon, Jun-Ho Cho, Lisa Zhang, Brian C Mansfield, Janice Y Chou
Glycogen storage disease type Ia (GSD-Ia) is characterized by impaired glucose homeostasis and long-term risks of hepatocellular adenoma (HCA) and carcinoma (HCC). We have shown that the non-tumor-bearing (NT), recombinant adeno-associated virus (rAAV) vector-treated GSD-Ia mice (AAV-NT mice) expressing a wide range (0.9-63%) of normal hepatic glucose-6-phosphatase-α activity maintain glucose homeostasis and display physiologic features mimicking animals living under calorie restriction (CR). We now show that in AAV-NT mice, the signaling pathways of the CR mediators, AMP-activated protein kinase (AMPK) and sirtuin-1 are activated...
March 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28334769/using-affective-judgement-to-increase-physical-activity-in-british-adults
#5
Alice S Forster, Penny Buykx, Neil Martin, Susannah Sadler, Ben Southgate, Lauren Rockliffe, Ian Walker
Mobile phone apps have been shown to increase physical activity (PA), but existing apps fail to target the emotional aspects of PA, which influence whether individuals are active. We developed an app that encourages individuals to focus on the emotional aspects of PA. We aimed to assess the acceptability of this app, and conduct a preliminary evaluation of efficacy. The app was developed in collaboration with users through focus groups. Seven users tested the app over 4 months and provided feedback on acceptability, aesthetics and functionality in a follow-up focus group...
February 27, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28334487/growing-up-with-perinatal-human-immunodeficiency-virus-a-life-not-expected
#6
Elaine Fay Williams
AIM AND OBJECTIVES: To describe the lived experience of young adults with perinatally acquired HIV (PaHIV). BACKGROUND: The advancement of the highly active antiretroviral treatment, PaHIV-infection has transformed into a chronic lifelong illness that is faced by young adults who grew up with HIV. The known challenges that are associated with HIV are poverty, stigma and social and emotional isolation. DESIGN: This was a qualitative single interview study of a convenience sample of PaHIV-infected young adults receiving care at a large metropolitan pediatric hospital...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28334483/activities-of-daily-living-trajectories-among-institutionalized-older-adults-a-prospective-study
#7
Huai-Ting Kuo, Kuan-Chia Lin, Chung-Fu Lan, I-Chuan Li
AIMS AND OBJECTIVES: To examine ADL trajectory groups among older residents in Taiwan, and to determine the relative risks of demographic characteristics and health status in explaining the trajectory group of ADL. BACKGROUND: Activity of daily living (ADL) is a crucial indicator of health status for institutionalized older adults. ADL is a dynamic process, and has differences in trajectory groups. DESIGN: This study was a 3-year longitudinal analysis of long-term care (LTC) facility residents in Taiwan...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28334453/not-in-my-backyard-ccs-sites-and-public-perception-of-ccs
#8
Carola Braun
Carbon capture and storage (CCS) is a technology that counteracts climate change by capturing atmospheric emissions of CO2 from human activities, storing them in geological formations underground. However, CCS also involves major risks and side effects, and faces strong public opposition. The whereabouts of 408 potential CCS sites in Germany were released in 2011. Using detailed survey data on the public perception of CCS, this study quantifies how living close to a potential storage site affects the acceptance of CCS...
March 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28334356/transient-cell-intrinsic-activity-regulates-the-migration-and-laminar-positioning-of-cortical-projection-neurons
#9
Nicolas Hurni, Marta Kolodziejczak, Ugo Tomasello, Joan Badia, Moritz Jacobshagen, Julien Prados, Alexandre Dayer
Neocortical microcircuits are built during development and require the coordinated assembly of excitatory glutamatergic projection neurons (PNs) into functional networks. Neuronal migration is an essential step in this process. In addition to cell-intrinsic mechanisms, external cues including neurotransmitters regulate cortical neuron migration, suggesting that early activity could influence this process. Here, we aimed to investigate the role of cell-intrinsic activity in migrating PNs in vivo using a designer receptor exclusively activated by a designer drug (DREADD) chemogenetic approach...
March 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334348/evaluation-of-the-potential-for-secondary-kill-for-ingested-insecticides-in-the-common-bed-bug-hemiptera-cimicidae
#10
Yvonne K Matos, Angela Sierras, Coby Schal
Baits are a preferred method of urban pest management. Baits enable more targeted insecticide applications with a fraction of the active ingredient used in residual sprays. Bait translocation by foragers, and consequent secondary kill of nonforagers, enhances bait effectiveness in social insects, and in other group-living species like German cockroaches (Blattella germanica L.). We investigated the potential for secondary kill in bed bugs (Cimex lectularius L.), another gregarious species, using a liquid bait...
March 20, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28333995/better-living-through-conifer-removal-a-demographic-analysis-of-sage-grouse-vital-rates
#11
John P Severson, Christian A Hagen, Jason D Tack, Jeremy D Maestas, David E Naugle, James T Forbes, Kerry P Reese
Sagebrush (Artemisia spp.) obligate wildlife species such as the imperiled greater sage-grouse (Centrocercus urophasianus) face numerous threats including altered ecosystem processes that have led to conifer expansion into shrub-steppe. Conifer removal is accelerating despite a lack of empirical evidence on grouse population response. Using a before-after-control-impact design at the landscape scale, we evaluated effects of conifer removal on two important demographic parameters, annual survival of females and nest survival, by monitoring 219 female sage-grouse and 225 nests in the northern Great Basin from 2010 to 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28333608/morbidity-in-pregnant-women-associated-with-unverified-penicillin-allergies-antibiotic-use-and-group-b-streptococcus-infections
#12
Shilpa H Desai, Michael S Kaplan, Qiaoling Chen, Eric M Macy
CONTEXT: The morbidity potentially associated with unverified penicillin allergy in pregnant women, with and without group B streptococcus (GBS) infections, is unknown. Penicillin allergy testing is safe during pregnancy but is done infrequently. OBJECTIVE: To determine morbidity associated with antibiotic use in a large cohort of pregnant women, with and without an unverified history of penicillin allergy, and with and without GBS. DESIGN: Retrospective...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28332754/detection-of-carbapenemase-producing-organisms-with-a-carbapenem-based-fluorogenic-probe
#13
Wuyu Mao, Lingying Xia, Hexin Xie
Antibiotic resistance has become a major challenge to public health worldwide. This crisis is further aggravated by the increasing emergence of bacterial resistance to carbapenems, typically considered as the antibiotics of last resort, which is mainly due to the production of carbapenem-hydrolyzing carbapenemases in bacteria. Herein, the carbapenem-based fluorogenic probe CB-1 with an unprecedented enamine-BODIPY switch is developed for the detection of carbapenemase activity. This reagent is remarkably specific towards carbapenemases over other prevalent β-lactamases...
March 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28332337/profiles-of-physical-function-physical-activity-and-sedentary-behavior-and-their-associations-with-mental-health-in-residents-of-assisted-living-facilities
#14
Saengryeol Park, Cecilie Thøgersen-Ntoumani, Nikos Ntoumanis, Andreas Stenling, Sally A M Fenton, Jet J C S Veldhuijzen van Zanten
BACKGROUND: The current study used latent profile analyses to identify classes of older participants based on physical health, physical function, light physical activity, moderate-to-vigorous physical activity, and sedentary behavior, and then examined differences in mental health between these classes. METHODS: Eighty-five residents (M = 77.5 years old, SD = 8.2) from assisted living facilities participated. Light physical activity, moderate-to-vigorous physical activity, and sedentary behavior were assessed by accelerometers, physical function was measured using different tasks (mobility, grip strength, and spirometry), and body mass index was calculated...
March 2017: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/28332150/dynamic-nature-of-presenilin1-%C3%AE-secretase-implication-for-alzheimer-s-disease-pathogenesis
#15
REVIEW
Katarzyna Marta Zoltowska, Oksana Berezovska
Presenilin 1 (PS1) is a catalytic component of the γ-secretase complex, responsible for the intramembraneous cleavage of more than 90 type I transmembrane proteins, including Alzheimer's disease (AD)-related amyloid precursor protein (APP). The γ-secretase-mediated cleavage of the APP C-terminal membrane stub leads to the production of various amyloid β (Aβ) species. The assembly of Aβ into neurotoxic oligomers, which causes synaptic dysfunction and neurodegeneration, is influenced by the relative ratio of the longer (Aβ42/43) to shorter Aβ (Aβ40) peptides...
March 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28332018/seasonal-loss-and-resumption-of-circadian-rhythms-in-hibernating-arctic-ground-squirrels
#16
Cory T Williams, Maya Radonich, Brian M Barnes, C Loren Buck
Circadian clocks are near universal among organisms and play a key role in coordinating physiological and metabolic functions to anticipate or coincide with predictable daily changes in the physical and social environment. However, whether circadian rhythms persist and are functionally important during hibernation in all mammals is currently unclear. We examined whether circadian rhythms of body temperature (T b) persist during multi-day, steady-state torpor and investigated the association between timing of animal emergence, exposure to light, and resumption of activity and T b rhythms in free-living and captive male arctic ground squirrels...
March 22, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28331527/determinants-to-antiretroviral-treatment-non-adherence-among-adult-hiv-aids-patients-in-northern-ethiopia
#17
Berhe Beyene Gebrezgabher, Yigzaw Kebede, Melaku Kindie, Desalegn Tetemke, Mebrahtu Abay, Yalemzewod Assefa Gelaw
BACKGROUND: Adhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death among people's living human immunodeficiency virus. Though manifold factors have reported as determinant factors of antiretroviral therapy adherence status, perhaps determinants of non-adherence differ up on the activities of patients in the study setting. METHODS: An institution based unmatched case-control study was conducted in Aksum town. Individuals who had a 6-month follow-up with complete individual information were included in the study...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28331455/exploring-patient-caregiver-and-healthcare-provider-perceptions-of-caring-for-patients-with-heart-failure-what-are-the-implications
#18
Betty M Kennedy, Vijayendra Jaligam, Beverly K Conish, William D Johnson, Brian Melancon, Peter T Katzmarzyk
BACKGROUND: Heart failure (HF) is an incurable and frequently progressive disease. Symptoms of HF may impair the ability of patients to perform daily living activities. As HF progresses, patients typically increase their reliance on caregivers. The purpose of this study was to determine what roles patients and caregivers perceive and desire for themselves in managing HF and to compare and contrast these roles with those perceived by healthcare providers. METHODS: A purposive sample (60 patients, 22 caregivers, and 11 healthcare providers) was enrolled in the study...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28331091/ebolaviruses-associated-with-differential-pathogenicity-induce-distinct-host-responses-in-human-macrophages
#19
Judith Olejnik, Adriana Forero, Laure R Deflubé, Adam J Hume, Whitney A Manhart, Andrew Nishida, Andrea Marzi, Michael G Katze, Hideki Ebihara, Angela L Rasmussen, Elke Mühlberger
Ebola virus (EBOV) and Reston virus (RESTV) are members of the Ebolavirus genus which greatly differ in their pathogenicity. While EBOV causes a severe disease in humans characterized by a dysregulated inflammatory response and elevated cytokine and chemokine production, there are no reported disease-associated human cases of RESTV infection, suggesting that RESTV is non-pathogenic for humans. The underlying mechanisms determining the pathogenicity of different ebolavirus species are not yet known. In this study we dissect the host response to EBOV and RESTV infection in primary human monocyte-derived macrophages (MDMs)...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28331075/myosin-activity-drives-actomyosin-bundle-formation-and-organization-in-contractile-cells-of-the-c-elegans-spermatheca
#20
Alison C E Wirshing, Erin J Cram
Stress fibers, contractile actomyosin bundles, are important for cellular force production and adaptation to physical stress and have been well-studied within the context of cell migration. However, less is known about actomyosin bundle formation and organization in vivo and in specialized contractile cells, such as smooth muscle and myoepithelial cells. The Caenorhabditis elegans spermatheca is a bag-like organ of 24 myoepithelial cells that houses the sperm and is the site of fertilization. During ovulation, spermathecal cells are stretched by oocyte entry and then coordinately contract to expel the fertilized embryo into the uterus...
March 22, 2017: Molecular Biology of the Cell
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