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https://www.readbyqxmd.com/read/27804171/development-and-validation-of-case-finding-algorithms-for-the-identification-of-patients-with-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-in-large-healthcare-administrative-databases
#1
Antoine G Sreih, Narender Annapureddy, Jason Springer, George Casey, Kevin Byram, Andy Cruz, Maya Estephan, Vince Frangiosa, Michael D George, Mei Liu, Adam Parker, Sapna Sangani, Rebecca Sharim, Peter A Merkel
PURPOSE: The aim of this study was to develop and validate case-finding algorithms for granulomatosis with polyangiitis (Wegener's, GPA), microscopic polyangiitis (MPA), and eosinophilic GPA (Churg-Strauss, EGPA). METHODS: Two hundred fifty patients per disease were randomly selected from two large healthcare systems using the International Classification of Diseases version 9 (ICD9) codes for GPA/EGPA (446.4) and MPA (446.0). Sixteen case-finding algorithms were constructed using a combination of ICD9 code, encounter type (inpatient or outpatient), physician specialty, use of immunosuppressive medications, and the anti-neutrophil cytoplasmic antibody type...
December 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27663257/advances-in-imaging-and-automated-quantification-of-pulmonary-diseases-in-non-neoplastic-diseases
#2
REVIEW
Fernanda Balbinot, Álvaro da Costa Batista Guedes, Douglas Zaione Nascimento, Juliana Fischman Zampieri, Giordano Rafael Tronco Alves, Edson Marchiori, Adalberto Sperb Rubin, Bruno Hochhegger
Histological examination has always been the gold standard for the detection and quantification of lung remodeling. However, this method has some limitations regarding the invasiveness of tissue acquisition. Quantitative imaging methods enable the acquisition of valuable information on lung structure and function without the removal of tissue from the body; thus, they are useful for disease identification and follow-up. This article reviews the various quantitative imaging modalities used currently for the non-invasive study of chronic obstructive pulmonary disease, asthma, and interstitial lung diseases...
December 2016: Lung
https://www.readbyqxmd.com/read/27566377/office-based-dlco-tests-help-pulmonologists-to-make-important-clinical-decisions
#3
REVIEW
Paul Enright Md
Measurement of diffusing capacity of the lungs for carbon monoxide (DLCO), also known as transfer factor, is the second most important pulmonary function test (PFT), after spirometry. Previously available only in hospital-based PFT labs, DLCO testing is now available at outpatient clinics using a portable device. Compared to spirometry tests, assessments with these devices require very little effort. The patient breathes quietly, inhales the test gas, holds the breath for ten seconds, and then exhales. In adult smokers with post-bronchodilator airway obstruction, a low DLCO greatly increases the probability of the emphysema phenotype of COPD due to cigarette smoking, while a normal DLCO makes chronic asthma more likely...
September 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27520469/chronic-eosinophilic-pneumonia-presenting-with-ipsilateral-pleural-effusion-a-case-report
#4
Narin Sriratanaviriyakul, Hanh H La, Timothy E Albertson
BACKGROUND: Chronic eosinophilic pneumonia is a rare idiopathic interstitial lung disease. The nearly pathognomonic radiographic finding is the peripheral distribution of alveolar opacities. Pleural effusions are rarely seen. We report a case of chronic eosinophilic pneumonia with transudative eosinophilic pleural effusion. CASE PRESENTATION: A 57-year-old Hispanic woman, a nonsmoker with a history of controlled asthma, presented to the hospital with unresolving pneumonia despite three rounds of antibiotics over a 2-month period...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27461264/variable-course-of-disease-of-rheumatoid-arthritis-associated-usual-interstitial-pneumonia-compared-to-other-subtypes
#5
Hanna M Nurmi, Minna K Purokivi, Miia S Kärkkäinen, Hannu-Pekka Kettunen, Tuomas A Selander, Riitta L Kaarteenaho
BACKGROUND: In rheumatoid arthritis-associated interstitial lung disease (RA-ILD), occurring in 10 % of patients with patients with RA, usual interstitial pattern (UIP) has shown to associate with poor prognosis but more detailed data about the course of the disease in different subtypes is limited. Our aim was to compare the disease course of patients with RA-ILD categorized into either UIP or other types of ILDs. METHODS: Clinical and radiological information of 59 patients with RA-ILD were re-assessed and re-classified into UIP or non-UIP groups, followed by a between-group comparison of demographic data, lung function, survival, cause of death and comorbidities...
July 27, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27136656/increasing-prevalence-of-chronic-lung-disease-in-veterans-of-the-wars-in-iraq-and-afghanistan
#6
Mary Jo Pugh, Carlos A Jaramillo, Kar-Wei Leung, Paola Faverio, Nicholas Fleming, Eric Mortensen, Megan E Amuan, Chen-Pin Wang, Blessen Eapen, Marcos Restrepo, Michael J Morris
Research from the wars in Afghanistan and Iraq have focused on traumatic brain injury (TBI) and mental health conditions; however, it is becoming clear that other health concerns, such as respiratory illnesses, warrant further scientific inquiry. Early reports from theater and postdeployment health assessments suggested an association with deployment-related exposures (e.g., sand, burn pits, chemical, etc.) and new-onset respiratory symptoms. We used data from Veterans Affairs medical encounters between fiscal years 2003 and 2011 to identify trends in chronic obstructive pulmonary disease, asthma, and interstitial lung disease in veterans...
May 2016: Military Medicine
https://www.readbyqxmd.com/read/26833590/interstitial-changes-in-asthma-copd-overlap-syndrome-acos
#7
Sahoko Chiba, Kimitake Tsuchiya, Yoshihisa Nukui, Manabu Sema, Meiyo Tamaoka, Yuki Sumi, Yasunari Miyazaki, Naohiko Inase
INTRODUCTION: Asthma-COPD overlap syndrome (ACOS) is the widely recognized syndrome of asthma and COPD coexisting together. Cigarette smoking is a known risk factor for ACOS and is reported to be associated with interstitial lung diseases (ILDs). Subclinical ILDs have been frequently detected in smokers' lungs by radiological and pathological examinations. This finding raises the possibility that unrecognized mild interstitial changes take place in lungs with ACOS. OBJECTIVES: We sought to determine whether interstitial changes were present in the lungs of patients with ACOS and to characterize the clinical features of ACOS with interstitial changes...
February 2, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26822248/interstitial-lung-disease-in-a-female-worker-sensitized-to-epoxy-resins-a-case-report-submitted-for-discussion
#8
LETTER
Roberto Calisti
No abstract text is available yet for this article.
January 20, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/26789431/-respiratory-muscle-training-state-of-the-art
#9
O Göhl, D J Walker, S Walterspacher, D Langer, C M Spengler, T Wanke, M Petrovic, R-H Zwick, S Stieglitz, R Glöckl, D Dellweg, H-J Kabitz
Specific respiratory muscle training (IMT) improves the function of the inspiratory muscles. According to literature and clinical experience, there are 3 established methods: 1.) resistive load 2.) threshold load and 3.) normocapnic hyperpnea. Each training method and the associated devices have specific characteristics. Setting up an IMT should start with specific diagnostics of respiratory muscle function and be followed by detailed individual introduction to training. The aim of this review is to take a closer look at the different training methods for the most relevant indications and to discuss these results in the context of current literature...
January 2016: Pneumologie
https://www.readbyqxmd.com/read/26770230/the-korean-cough-guideline-recommendation-and-summary-statement
#10
REVIEW
Chin Kook Rhee, Ji Ye Jung, Sei Won Lee, Joo-Hee Kim, So Young Park, Kwang Ha Yoo, Dong Ah Park, Hyeon-Kyoung Koo, Yee Hyung Kim, Ina Jeong, Je Hyeong Kim, Deog Kyeom Kim, Sung-Kyoung Kim, Yong Hyun Kim, Jinkyeong Park, Eun Young Choi, Ki-Suck Jung, Hui Jung Kim
Cough is one of the most common symptom of many respiratory diseases. The Korean Academy of Tuberculosis and Respiratory Diseases organized cough guideline committee and cough guideline was developed by this committee. The purpose of this guideline is to help clinicians to diagnose correctly and treat efficiently patients with cough. In this article, we have stated recommendation and summary of Korean cough guideline. We also provided algorithm for acute, subacute, and chronic cough. For chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered...
January 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/26761627/pulmonary-health-effects-of-agriculture
#11
REVIEW
Tara M Nordgren, Kristina L Bailey
PURPOSE OF REVIEW: Occupational exposures in the agricultural industry are associated with numerous lung diseases, including chronic obstructive pulmonary disease, asthma, hypersensitivity pneumonitis, lung cancer, and interstitial lung diseases. Efforts are ongoing to ascertain contributing factors to these negative respiratory outcomes and improve monitoring of environmental factors leading to disease. In this review, recently published studies investigating the deleterious effects of occupational exposures in the agricultural industry are discussed...
March 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/26683924/intrathoracic-involvements-of-immunoglobulin-g4-related-sclerosing-disease
#12
Yunyun Fei, Juhong Shi, Wei Lin, Yu Chen, Ruie Feng, Qingjun Wu, Xin Gao, Wenbing Xu, Wen Zhang, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
To investigate clinical and radiological features of IgG4-related disease (IgG4-RD) patients with intrathoracic involvement. A prospective cohort study was performed and IgG4-RD patients were enrolled from January 2011 to March 2015 in Peking Union Medical College Hospital, in which the clinical and radiological characteristics of IgG4-RD patients with intrathoracic involvement were summarized. Out of total 248 cases with IgG4-RD, 87 cases had intrathoracic lesions, including 58 male cases and 29 female cases, with average age of 54...
December 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26555431/incidence-and-complications-of-interstitial-lung-disease-in-users-of-tocilizumab-rituximab-abatacept-and-anti-tumor-necrosis-factor-%C3%AE-agents-a-retrospective-cohort-study
#13
Jeffrey R Curtis, Khaled Sarsour, Pavel Napalkov, Laurie A Costa, Kathy L Schulman
INTRODUCTION: Interstitial lung disease (ILD) is a common extra-articular condition in rheumatoid arthritis (RA), but few studies have systematically investigated its incidence and risk factors in patients receiving anti-tumor necrosis factor-alpha (anti-TNFα) agents or alternate mechanisms of action (MOAs) (e.g., T-cell, B-cell, and interleukin-6 inhibitors). METHODS: RA patients at least 18 years old were selected from the MarketScan databases (2010-2012) if they had at least one prescription/administration of abatacept, rituximab, tocilizumab, or anti-TNF after having discontinued a different biologic agent and meeting enrollment criteria...
November 11, 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26289061/recent-advances-in-paediatric-respiratory-medicine
#14
REVIEW
Andrew Turnbull, Ian M Balfour-Lynn
This review highlights important advances in paediatric respiratory medicine since 2014, excluding cystic fibrosis. It focuses mainly on the more common conditions, bronchopulmonary dysplasia, bronchiolitis and preschool wheezing, asthma, pneumonia and sleep, and highlights some of the rarer conditions such as primary ciliary dyskinesia and interstitial lung disease (ILD).
February 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/26130026/increased-circulating-fibrocytes-are-associated-with-higher-reticulocyte-percent-in-children-with-sickle-cell-anemia
#15
Matthew S Karafin, Shibani Dogra, Mark Rodeghier, Marie Burdick, Borna Mehrad, C Edward Rose, Robert M Strieter, Michael R DeBaun, Robert C Strunk, Joshua J Field
BACKGROUND: Interstitial lung disease is common in patients with sickle cell anemia (SCA). Fibrocytes are circulating cells implicated in the pathogenesis of pulmonary fibrosis and airway remodeling in asthma. In this study, we tested the hypotheses that fibrocyte levels are: (1) increased in children with SCA compared to healthy controls, and (2) associated with pulmonary disease. PROCEDURE: Cross-sectional cohort study of children with SCA who participated in the Sleep Asthma Cohort Study...
March 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/26129864/-dyspnea-in-airway-and-pulmonary-diseases
#16
J Niedermeyer
The subjective perception of pulmonary dyspnea varies based on behavioral and physiological responses. Acute pulmonary dyspnea is the most common symptom of diseases of the airways and the lungs and the differential diagnosis includes harmless causes, such as lack of training as well as acute life-threatening diseases, such as thromboembolism, obstruction of the upper or lower airway, pneumonia, pulmonary hemorrhage and pneumothorax. Most cases of chronic pulmonary dyspnea result from asthma, chronic obstructive pulmonary disease (COPD), pulmonary arterial hypertension, pulmonary fibrosis and pleural disorders...
August 2015: Der Internist
https://www.readbyqxmd.com/read/26106641/exhaled-breath-condensate-technical-and-diagnostic-aspects
#17
REVIEW
Efstathia M Konstantinidi, Andreas S Lappas, Anna S Tzortzi, Panagiotis K Behrakis
PURPOSE: The aim of this study was to evaluate the 30-year progress of research on exhaled breath condensate in a disease-based approach. METHODS: We searched PubMed/Medline, ScienceDirect, and Google Scholar using the following keywords: exhaled breath condensate (EBC), biomarkers, pH, asthma, gastroesophageal reflux (GERD), smoking, COPD, lung cancer, NSCLC, mechanical ventilation, cystic fibrosis, pulmonary arterial hypertension (PAH), idiopathic pulmonary fibrosis, interstitial lung diseases, obstructive sleep apnea (OSA), and drugs...
2015: TheScientificWorldJournal
https://www.readbyqxmd.com/read/26023006/-lung-diseases-in-children
#18
REVIEW
O Sommerburg, J P Schenk, M A Mall
BACKGROUND: Lung diseases belong to the most common acute and chronic childhood diseases. With specific diagnostics and therapy the outcome of many congenital and acquired pulmonary diseases in children and adults can be substantially improved. OBJECTIVE: The aim of this review is the presentation and evaluation of important lung diseases in children taking recent developments into consideration. MATERIAL AND METHODS: This article presents a review of the literature on selected acute and chronic lung diseases in children and adolescents...
July 2015: Der Radiologe
https://www.readbyqxmd.com/read/25959386/mast-cells-in-airway-diseases-and-interstitial-lung-disease
#19
REVIEW
Glenn Cruse, Peter Bradding
Mast cells are major effector cells of inflammation and there is strong evidence that mast cells play a significant role in asthma pathophysiology. There is also a growing body of evidence that mast cells contribute to other inflammatory and fibrotic lung diseases such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. This review discusses the role that mast cells play in airway diseases and highlights how mast cell microlocalisation within specific lung compartments and their cellular interactions are likely to be critical for their effector function in disease...
May 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/25938529/spontaneous-pneumomediastinum-in-a-pediatric-patient-after-a-1600-m-run-case-report-and-literature-review
#20
Zachary C Booms, George A Barbee
Pneumomediastinum occurs as a result of traumatic or iatrogenic causes or in patients with preexisting lung conditions such as interstitial lung disease, asthma, and chronic obstructive pulmonary disease. Spontaneous pneumomedi-astinum (SPM), however, is rarely seen in clinical practice. The authors report the case of a 14-year-old boy who presented to the emergency department with chest discomfort and shortness of breath after a 1600-m run as part of a physical education class. The patient was found to have SPM, was admitted to the pediatric service for monitoring and pain control, and made a full recovery within 24 hours...
May 2015: Journal of the American Osteopathic Association
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