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https://www.readbyqxmd.com/read/27918777/global-regional-and-national-cancer-incidence-mortality-years-of-life-lost-years-lived-with-disability-and-disability-adjusted-life-years-for-32-cancer-groups-1990-to-2015-a-systematic-analysis-for-the-global-burden-of-disease-study
#1
Christina Fitzmaurice, Christine Allen, Ryan M Barber, Lars Barregard, Zulfiqar A Bhutta, Hermann Brenner, Daniel J Dicker, Odgerel Chimed-Orchir, Rakhi Dandona, Lalit Dandona, Tom Fleming, Mohammad H Forouzanfar, Jamie Hancock, Roderick J Hay, Rachel Hunter-Merrill, Chantal Huynh, H Dean Hosgood, Catherine O Johnson, Jost B Jonas, Jagdish Khubchandani, G Anil Kumar, Michael Kutz, Qing Lan, Heidi J Larson, Xiaofeng Liang, Stephen S Lim, Alan D Lopez, Michael F MacIntyre, Laurie Marczak, Neal Marquez, Ali H Mokdad, Christine Pinho, Farshad Pourmalek, Joshua A Salomon, Juan Ramon Sanabria, Logan Sandar, Benn Sartorius, Stephen M Schwartz, Katya A Shackelford, Kenji Shibuya, Jeff Stanaway, Caitlyn Steiner, Jiandong Sun, Ken Takahashi, Stein Emil Vollset, Theo Vos, Joseph A Wagner, Haidong Wang, Ronny Westerman, Hajo Zeeb, Leo Zoeckler, Foad Abd-Allah, Muktar Beshir Ahmed, Samer Alabed, Noore K Alam, Saleh Fahed Aldhahri, Girma Alem, Mulubirhan Assefa Alemayohu, Raghib Ali, Rajaa Al-Raddadi, Azmeraw Amare, Yaw Amoako, Al Artaman, Hamid Asayesh, Niguse Atnafu, Ashish Awasthi, Huda Ba Saleem, Aleksandra Barac, Neeraj Bedi, Isabela Bensenor, Adugnaw Berhane, Eduardo Bernabé, Balem Betsu, Agnes Binagwaho, Dube Boneya, Ismael Campos-Nonato, Carlos Castañeda-Orjuela, Ferrán Catalá-López, Peggy Chiang, Chioma Chibueze, Abdulaal Chitheer, Jee-Young Choi, Benjamin Cowie, Solomon Damtew, José das Neves, Suhojit Dey, Samath Dharmaratne, Preet Dhillon, Eric Ding, Tim Driscoll, Donatus Ekwueme, Aman Yesuf Endries, Maryam Farvid, Farshad Farzadfar, Joao Fernandes, Florian Fischer, Tsegaye Tewelde G/Hiwot, Alemseged Gebru, Sameer Gopalani, Alemayehu Hailu, Masako Horino, Nobuyuki Horita, Abdullatif Husseini, Inge Huybrechts, Manami Inoue, Farhad Islami, Mihajlo Jakovljevic, Spencer James, Mehdi Javanbakht, Sun Ha Jee, Amir Kasaeian, Muktar Sano Kedir, Yousef S Khader, Young-Ho Khang, Daniel Kim, James Leigh, Shai Linn, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Reza Malekzadeh, Deborah Carvalho Malta, Wagner Marcenes, Desalegn Markos, Yohannes A Melaku, Kidanu G Meles, Walter Mendoza, Desalegn Tadese Mengiste, Tuomo J Meretoja, Ted R Miller, Karzan Abdulmuhsin Mohammad, Alireza Mohammadi, Shafiu Mohammed, Maziar Moradi-Lakeh, Gabriele Nagel, Devina Nand, Quyen Le Nguyen, Sandra Nolte, Felix A Ogbo, Kelechi E Oladimeji, Eyal Oren, Mahesh Pa, Eun-Kee Park, David M Pereira, Dietrich Plass, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Mahfuzar Rahman, Saleem M Rana, Kjetil Søreide, Maheswar Satpathy, Monika Sawhney, Sadaf G Sepanlou, Masood Ali Shaikh, Jun She, Ivy Shiue, Hirbo Roba Shore, Mark G Shrime, Samuel So, Samir Soneji, Vasiliki Stathopoulou, Konstantinos Stroumpoulis, Muawiyyah Babale Sufiyan, Bryan L Sykes, Rafael Tabarés-Seisdedos, Fentaw Tadese, Bemnet Amare Tedla, Gizachew Assefa Tessema, J S Thakur, Bach Xuan Tran, Kingsley Nnanna Ukwaja, Benjamin S Chudi Uzochukwu, Vasiliy Victorovich Vlassov, Elisabete Weiderpass, Mamo Wubshet Terefe, Henock Gebremedhin Yebyo, Hassen Hamid Yimam, Naohiro Yonemoto, Mustafa Z Younis, Chuanhua Yu, Zoubida Zaidi, Maysaa El Sayed Zaki, Zerihun Menlkalew Zenebe, Christopher J L Murray, Mohsen Naghavi
Importance: Cancer is the second leading cause of death worldwide. Current estimates on the burden of cancer are needed for cancer control planning. Objective: To estimate mortality, incidence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 32 cancers in 195 countries and territories from 1990 to 2015. Evidence Review: Cancer mortality was estimated using vital registration system data, cancer registry incidence data (transformed to mortality estimates using separately estimated mortality to incidence [MI] ratios), and verbal autopsy data...
December 3, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27904449/tracheal-cancer-treatment-results-prognostic-factors-and-incidence-of-other-neoplasms
#2
Aleksandra Napieralska, Leszek Miszczyk, Sławomir Blamek
BACKGROUND: Tracheal cancers (TC) are rare and treatment results that are reported are typically not satisfactory. The purpose of this research was assessment of the results of treatment of TC patients, identification of potential additional surgery candidates, evaluation of prognostic factors, and assessment of the occurrence of other malignancies. PATIENTS AND METHODS: The Regional Cancer Database and the Hospital Database were searched for patients with tracheal neoplasms...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27867955/a-new-technique-to-repair-huge-tracheo-gastric-fistula-following-esophagectomy
#3
Francesco Paolo Caronia, Alfonso Fiorelli, Mario Santini, Roberto Alfano, Sergio Castorina
We reported the management of a life-threatening condition as a large tracheo-gastric fistula involved the carina, the left and the right bronchus that complicated Ivor Lewis esophagogastrectomy for esophageal cancer. An urgent right thoracotomy was performed and the tracheal defect was covered with a reversed pedicled pericardial patch reinforced with an intercostal muscle flap. Cervical esophagostomy and a feeding jejunostomy completed the operation. Five months later, the continuity of gastrointestinal tract was restored using a transverse colon...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27867870/thyroid-cancer-with-tracheal-invasion-a-pathological-estimation
#4
Vincenzo Pappalardo, Stefano La Rosa, Andrea Imperatori, Nicola Rotolo, Maria Laura Tanda, Andrea Sessa, Lorenzo Dominioni, Gianlorenzo Dionigi
We review the clinical and pathologic features of seven cases of papillary carcinoma of the thyroid that invaded the trachea and were treated by thyroidectomy, airway resection with reconstructive surgery over an interval of 15 years. We depicted the peculiarity of invasion of well differentiated papillary thyroid carcinoma (PTC) cells is perpendicularly oriented to the tracheal lumen, in between cartilaginous rings, along blood vessels and collagen fibers. Tracheal rings appear non-infiltrated in all histological sections of well differentiated PTC infiltrating the trachea...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27862678/comparison-of-synchronous-versus-staged-surgeries-for-patients-with-synchronous-double-cancers-of-the-esophagus-and-head-and-neck
#5
Akira Matsumoto, Masayuki Watanabe, Shinji Mine, Koujiro Nishida, Hironobu Shigaki, Kazuyoshi Kawabata, Katsuhiko Yanaga, Takeshi Sano
Esophageal and head and neck (H&N) cancers often occur synchronously, this study aimed to clarify the benefits and disadvantages of synchronous and staged operations for double H&N/esophagus cancers. We retrospectively reviewed 43 patients with synchronous double cancer of H&N and esophagus treated between July 2005 and July 2014, of whom 33 patients underwent synchronous operation (SYN) and 10 underwent staged operations (STG). We compared the short-term outcomes between the groups. Operation time was longer, amount of blood loss was larger, and hospital stay was longer in the SYN group than in each single surgery of the STG group...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27846176/mediastinoscopy-assisted-transhiatal-esophagectomy-for-esophageal-cancer-a-single-institutional-cohort-study
#6
Tsutomu Nomura, Takeshi Matsutani, Nobutoshi Hagiwara, Itsuro Fujita, Yoshiharu Nakamura, Hiroshi Makino, Masao Miyashita, Eiji Uchida
We compared the therapeutic outcomes of mediastinoscopy-assisted transhiatal esophagectomy (MATHE) with transthoracic esophagectomy (TTE), and with video-assisted thoracoscopic esophagectomy (VATS-E) for the treatment of esophageal cancer. Twenty patients underwent MATHE in our institute from 2001 to 2005 were enrolled. We evaluated the therapeutic outcomes, including perioperative complications and long-term prognosis after surgery, and compared these with 15 patients who underwent TTE during the same time period and 15 who underwent VATS-E at a later date...
December 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27829946/double-stenting-for-malignant-oesophago-respiratory-fistula
#7
Janusz Włodarczyk, Jarosław Kużdżał
INTRODUCTION: The close anatomical relationship between the oesophagus and bronchial tree results in formation of an oesophago-respiratory fistula in a subset of patients with advanced oesophageal or lung cancer. In those patients stenting of both the oesophagus and tracheobronchial tree is a valid option of palliative treatment. AIM: To determine the effectiveness, tolerance, quality of life, safety and survival after double stenting procedures. MATERIAL AND METHODS: Retrospective analysis of a prospectively collected database was performed, concerning consecutive patients with oesophago-respiratory fistulas treated with double stenting...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27815921/bronchial-artery-aneurysm-suggested-to-be-caused-by-metalic-tracheal-stent-migration
#8
Kiyoshi Sato, Satoshi Fumimoto, Takehisa Fukada, Kaoru Ochi, Takayuki Kataoka, Yoshio Ichihashi, Hidetoshi Satomi, Takuya Morita, Nobuharu Hanaoka, Yoshikatsu Okada, Takahiro Katsumata
Occurrence of bronchial artery aneurysm is rare, and it has been detected in less than 1 % of all selective bronchial arteriography cases. Here, we present a case of a bronchial artery aneurysm caused by a tracheal stent migration. A 59-year-old man was operated on for esophageal cancer, where an esophageal-tracheal fistula occurred 1 week after operation. Surgical repair of the esophageal-tracheal fistula was performed using a muscle flap, but this not results in fistula closure. Consequently, a self-expanding covered metallic tracheal stent was implanted for rescue, and this resulted in fistula closure...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27815477/effective-mediastinal-lymphadenectomy-for-esophageal-cancer-using-slender-tracheal-forceps-in-prone-position-thoracoscopic-esophagectomy
#9
Masanobu Nakajima, Masakazu Takahashi, Yasushi Domeki, Hitoshi Satomura, Hiroto Muroi, Maiko Kikuchi, Hideo Ogata, Satoru Yamaguchi, Kinro Sasaki, Makoto Sakai, Makoto Sohda, Tatsuya Miyazaki, Hiroyuki Kuwano, Hiroyuki Kato
BACKGROUND/AIM: Adequate mediastinal lymphadenectomy during thoracoscopic esophagectomy (TE) requires an extensive operating field. In order to rectify this problem, we developed slender tracheal forceps that can pass through a 12-mm trocar. PATIENTS AND METHODS: TE in the prone position was performed in 58 patients with esophageal cancer using slender tracheal forceps. Perioperative and postoperative clinical data were compared against those of 61 patients who underwent transthoracic open esophagectomy (OE)...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27793018/intraoperative-radiotherapy-for-the-treatment-of-thyroid-cancer-a-pilot-study
#10
Pei-Qiang Yi, Fang-Fang Nie, You-Ben Fan, Wei-Wei Yu, Chao-Su Hu, Xiao-Mao Guo, Jie Fu
We preliminarily evaluated the clinical feasibility and efficacy of intraoperative radiotherapy in patients with thyroid carcinoma. Nine thyroid cancer patients received intraoperative radiotherapy using an Intrabeam system. The dose was 3-4 Gy and the irradiation time ranged from 1 min 32 s to 7 min 33s. One case was a primary thyroid carcinoma, while the other cases were recurrent disease. Adverse effects, recurrence and survival were analyzed. In one patient, poorly differentiated thyroid carcinoma recurred 5 months after treatment, one patient developed a postoperative tracheal skin fistula, and one patient developed a wound infection...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27785076/primary-adenoid-cystic-carcinoma-of-the-trachea-with-thyroid-invasion-a-case-report-and-literature-review
#11
Dianjun Qi, Liang Feng, Jian Li, Bing Liu, Qingfu Zhang
Primary adenoid cystic carcinoma (ACC) of the trachea with thyroid invasion is very rare. In this report, we present a 46-year-old man with primary ACC of the trachea with thyroid invasion. ACC invasion of the thyroid is very rare and is easily misdiagnosed. The patient sought consultation due to a 6-month history of dysphagia and associated dyspnea. A contrast-enhanced computed tomography scan obtained at the time of admission revealed bilateral thyroid masses and tracheal wall thickening. The thyroid masses were fused to the trachea and the esophagus without discernible borders, intraoperatively...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27780931/marital-status-is-an-independent-prognostic-factor-for-tracheal-cancer-patients-an-analysis-of-the-seer-database
#12
Mu Li, Chen-Yang Dai, Yu-Ning Wang, Tao Chen, Long Wang, Ping Yang, Dong Xie, Rui Mao, Chang Chen
BACKGROUND: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. RESULTS: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27747102/neoadjuvant-therapy-in-differentiated-thyroid-cancer
#13
Rajan P Dang, Daniel McFarland, Valerie H Le, Nadia Camille, Brett A Miles, Marita S Teng, Eric M Genden, Krzysztof J Misiukiewicz
Objectives. Invasion of differentiated thyroid cancer (DTC) into surrounding structures can lead to morbid procedures such as laryngectomy and tracheal resection. In these patients, there is a potential role for neoadjuvant therapy. Methods. We identified three studies involving the treatment of DTC with neoadjuvant chemotherapy: two from Slovenia and one from Japan. Results. These studies demonstrate that in selected situations, neoadjuvant chemotherapy can have a good response and allow for a more complete surgical resection, the treatment of DTC...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27714538/comparison-of-salvage-total-pharyngolaryngectomy-and-cervical-esophagectomy-between-hypopharyngeal-cancer-and-cervical-esophageal-cancer
#14
Katsushi Takebayashi, Yasuhiro Tsubosa, Tomoyuki Kamijo, Yoshiyuki Iida, Atsushi Imai, Masato Nagaoka, Takashi Kitani, Masahiro Niihara, Eisuke Booka, Ayako Shimada, Masahiro Nakagawa, Tetsuro Onitsuka
BACKGROUND: Total pharyngolaryngectomy and cervical esophagectomy (TPLCE) after chemoradiotherapy remains a challenge because of the high rate of complications and few available data on outcomes and safety. The purpose of this study was to evaluate the clinical significance of salvage TPLCE and to compare treatment outcomes between hypopharyngeal cancer and cervical esophageal cancer. METHODS: Data from 37 consecutive patients who were diagnosed with potentially resectable hypopharyngeal and cervical esophageal cancer after chemoradiotherapy were retrospectively analyzed...
October 6, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27713056/cross-disciplinary-analysis-of-lymph-node-classification-in-lung-cancer-on-computed-tomography
#15
Ahmed H El-Sherief, Charles T Lau, Nancy A Obuchowski, Atul C Mehta, Thomas W Rice, Eugene H Blackstone
BACKGROUND: Accurate and consistent regional lymph node classification (N) is an important element in the staging and multidisciplinary management of lung cancer. Regional lymph node definition sets-lymph node maps-have been created to standardize N. In 2009, the International Association for the Study of Lung Cancer (IASLC) introduced a lymph node map to supersede all pre-existing lymph node maps. AIM: To study if, and how lung cancer specialists apply the IASLC lymph node map when classifying thoracic lymph nodes encountered on computed tomography (CT) during lung cancer staging...
October 3, 2016: Chest
https://www.readbyqxmd.com/read/27695394/risk-factors-for-complications-after-pharyngolaryngectomy-with-total-esophagectomy
#16
Eisuke Booka, Yasuhiro Tsubosa, Masahiro Niihara, Wataru Takagi, Katsushi Takebayashi, Ayako Shimada, Takashi Kitani, Masato Nagaoka, Atsushi Imai, Tomoyuki Kamijo, Yoshiyuki Iida, Tetsuro Onitsuka, Masahiro Nakagawa, Hiroya Takeuchi, Yuko Kitagawa
BACKGROUND: Pharyngolaryngectomy with total esophagectomy (PLTE) is an effective surgical treatment for synchronous or metachronous hypopharyngeal or laryngeal cancer and thoracic esophageal cancer, although it is more invasive than esophagectomy and total pharyngolaryngectomy. The aim of this study was to identify risk factors for complications after PLTE. METHODS: From November 2002 to December 2014, a total of 8 patients underwent PLTE at the Shizuoka Cancer Center Hospital, Shizuoka, Japan...
2016: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/27693136/centrosome-amplification-increases-single-cell-branching-in-post-mitotic-cells
#17
Delia Ricolo, Myrto Deligiannaki, Jordi Casanova, Sofia J Araújo
Centrosome amplification is a hallmark of cancer, although we are still far from understanding how this process affects tumorigenesis [1, 2]. Besides the contribution of supernumerary centrosomes to mitotic defects, their biological effects in the post-mitotic cell are not well known. Here, we exploit the effects of centrosome amplification in post-mitotic cells during single-cell branching. We show that Drosophila tracheal cells with extra centrosomes branch more than wild-type cells. We found that mutations in Rca1 and CycA affect subcellular branching, causing tracheal tip cells to form more than one subcellular lumen...
September 17, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27663899/role-of-keap1-nrf2-and-tp53-mutations-in-lung-squamous-cell-carcinoma-development-and-radiation-resistance
#18
Youngtae Jeong, Ngoc T Hoang, Alexander Lovejoy, Henning Stehr, Aaron M Newman, Andrew J Gentles, William Kong, Diana Truong, Shanique Martin, Aadel Chaudhuri, Diane Heiser, Li Zhou, Carmen Say, Justin N Carter, Susan M Hiniker, Billy W Loo, Robert B West, Philip Beachy, Ash A Alizadeh, Maximilian Diehn
Lung squamous cell carcinomas (LSCC) pathogenesis remains incompletely understood and biomarkers predicting treatment response remain lacking. Here we describe novel murine LSCC models driven by loss of Trp53 and Keap1, both of which are frequently mutated in human LSCCs. Homozygous inactivation of Keap1 or Trp53 promoted airway basal stem cell (ABSC) self-renewal, suggesting that mutations in these genes lead to expansion of mutant stem cell clones. Deletion of Trp53 and Keap1 in ABSCs, but not more differentiated tracheal cells, produced tumors recapitulating histological and molecular features of human LSCCs, indicating that they represent the likely cell of origin in this model...
September 23, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27630087/distribution-patterns-of-metastases-in-recurrent-laryngeal-nerve-lymph-nodes-in-patients-with-squamous-cell-esophageal-cancer
#19
Takashi Kanemura, Tomoki Makino, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
Esophageal cancers frequently metastasize to recurrent laryngeal nerve lymph nodes (RLNNs). Knowledge of anatomic metastatic RLNN (mRLNN) distributions is needed for lymph node dissection during esophageal cancer surgery. Among 189 patients with esophageal cancer who underwent esophagectomy between 2008 and 2010, 51 (27.0%) had mRLNN. Sixty-four mRLNNs (right, 31; left, 33) were identified via preoperative computed tomography (CT); more than 2 unilateral metastases and/or nodes with unclear boundaries were excluded...
September 15, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27621904/evaluation-of-airway-resistance-in-primary-small-cell-carcinoma-of-the-trachea-by-mostgraph-a-case-study
#20
Eri Hagiwara, Yasuhiro Gon, Kentaro Hayashi, Mai Takahashi, Yuko Iida, Hisato Hiranuma, Yoshiko Nakagawa, Tsukasa Hataoka, Kenji Mizumura, Shuichiro Maruoka, Tetsuo Shimizu, Noriaki Takahashi, Shu Hashimoto
The case subject was a 58-year-old woman who presented to our hospital with a chief complaint of respiratory discomfort. Wheezing could be heard in both lungs; treatment was initiated with inhaled steroids for suspected bronchial asthma. However, 1 week later, the respiratory discomfort had not improved and the wheezing sound had progressed to the neck area. Upper airway obstruction was suspected; therefore, chest computed tomography (CT) was performed, revealing tracheal stenosis caused by a tumor in the upper airway...
August 2016: Journal of Thoracic Disease
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