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Carbapenems

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https://www.readbyqxmd.com/read/29351668/evaluation-of-the-rapid-carbapenem-inactivation-method-rcim-a-phenotypic-screening-test-for-carbapenemase-producing-enterobacteriaceae
#1
Madalina-Maria Muntean, Andrei-Alexandru Muntean, Lauraine Gauthier, Elodie Creton, Garance Cotellon, Mircea Ioan Popa, Rémy A Bonnin, Thierry Naas
Objectives: Fast and accurate diagnostic tests to identify carbapenemase-producing Enterobacteriaceae (CPE) are mandatory for proper antimicrobial therapy and implementing infection control measures. Here, we have developed a rapid Carbapenem Inactivation Method (rCIM) for CPE detection. Methods: The rCIM consists of the incubation of a potential carbapenemase producer with meropenem discs and use of the resulting supernatant to challenge a susceptible indicator strain...
January 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29351236/trends-in-resistance-to-extended-spectrum-cephalosporins-and-carbapenems-among-escherichia-coli-and-klebsiella-spp-isolates-in-a-district-in-western-india-during-2004-2014
#2
Ingvild Odsbu, Smita Khedkar, Frida Lind, Uday Khedkar, Sandeep S Nerkar, Nicola Orsini, Ashok J Tamhankar, Cecilia Stålsby Lundborg
Surveillance data on the level of resistant bacteria is needed to inform strategies to reduce the development and spread of antibiotic resistance. The aim of this study was to determine the non-susceptibility trends to extended-spectrum cephalosporins and carbapenems among Escherichia coli and Klebsiella spp. isolates from the district of Nashik in Western India during the period 2004-2014. Antibacterial susceptibility testing of clinical isolates was performed using Kirby-Bauer disc diffusion method to determine inhibitory zone diameters...
January 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29351187/high-proportions-of-multidrug-resistant-acinetobacter-spp-isolates-in-a-district-in-western-india-a-four-year-antibiotic-susceptibility-study-of-clinical-isolates
#3
Ingvild Odsbu, Smita Khedkar, Uday Khedkar, Sandeep S Nerkar, Ashok J Tamhankar, Cecilia Stålsby Lundborg
The purpose of the study was to determine the proportions of multidrug-resistant (MDR) Acinetobacter spp. isolates from the district of Nashik in Western India during the period from 2011-2014. Antibacterial susceptibility testing of isolates from inpatients and outpatients was performed using Kirby-Bauer disc diffusion method to determine inhibitory zone diameters. Proportions of non-susceptible isolates were calculated from the antibacterial susceptibility data. MDR was defined as an isolate being non-susceptible to at least one antibacterial agent in at least three antibacterial categories...
January 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29350524/development-of-a-multiplexed-microsphere-pcr-for-rapid-culture-free-detection-and-gram-typing-of-bacteria-in-human-blood-samples
#4
Fang Liang, Daniel J Browne, Megan J Gray, Kate H Gartlan, David D Smith, Ross Barnard, Geoff R Hill, Simon Robert Corrie, Kate Markey
Blood stream infection is a significant clinical problem, particularly in vulnerable patient groups such as those undergoing chemotherapy and bone marrow transplantation. Clinical diagnostics for suspected blood stream infection remain centered around blood culture (highly variable timing, hours to days), and empiric use of broad-spectrum antibiotics is often employed for patients presenting with febrile neutropenia. Gram-typing provides the first opportunity to target therapy (e.g. combinations containing vancomycin or teicoplanin for Gram-positives; piperacillin-tazobactam or a carbapenem for Gram-negatives), however current approaches require blood culture...
January 19, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29348810/structure-based-virtual-screening-for-the-discovery-of-novel-inhibitors-of-new-delhi-metallo-%C3%AE-lactamase-1
#5
Francesca Spyrakis, Giuseppe Celenza, Francesca Marcoccia, Matteo Santucci, Simon Cross, Pierangelo Bellio, Laura Cendron, Mariagrazia Perilli, Donatella Tondi
Bacterial resistance has become a worldwide concern after the emergence of metallo-β-lactamases (MBLs). They represent one of the major mechanisms of bacterial resistance against beta-lactam antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 NDM-1, the most prevalent type, is extremely efficient in inactivating nearly all-available antibiotics including last resort carbapenems. No inhibitors for NDM-1 are currently available in therapy, making the spread of NDM-1 producing bacterial strains a serious menace...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29344351/endemic-carbapenem-nonsusceptible-acinetobacter-baumannii-calcoaceticus-complex-in-intensive-care-units-of-the-national-referral-hospital-in-jakarta-indonesia
#6
Yulia Rosa Saharman, Anis Karuniawati, Rudyanto Sedono, Dita Aditianingsih, Pratiwi Sudarmono, Wil H F Goessens, Corné H W Klaassen, Henri A Verbrugh, Juliëtte A Severin
Background: Carbapenem-nonsusceptible A. baumannii-calcoaceticus complex have emerged worldwide, but the epidemiology in Indonesian hospitals has not been studied. Methods: A prospective observational study was performed on the intensive care units (ICUs) of the national referral hospital in Jakarta-Indonesia, in 2013 and 2014. All consecutive adult patients admitted and hospitalized for >48 h in ICUs were included. Basic and clinical data at admission were recorded...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29343171/prognosis-of-acute-respiratory-distress-syndrome-in-patients-with-hematological-malignancies
#7
Gil Myeong Seong, Yunkyoung Lee, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
INTRODUCTION: The intensive care unit (ICU) admission of patients with hematologic malignancies is gradually increasing. Life-threatening events are common, and acute respiratory distress syndrome (ARDS) is one of the most critical conditions. The aim of this study was to investigate the clinical characteristics and outcomes of ARDS in patients with hematological malignancies admitted to the ICU. METHODS: A retrospective study was performed on all patients with ARDS with hematological malignancies in a single tertiary teaching hospital between 2008 and 2015...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29341954/carbapenemase-production-of-clinical-isolates-acinetobacter-baumannii-and-pseudomonas-aeruginosa-from-a-bulgarian-university-hospital
#8
Atanaska P Petrova, Irina D Stanimirova, Ivan N Ivanov, Michael M Petrov, Tsonka M Miteva-Katrandzhieva, Vasil I Grivnev, Velichka S Kardjeva, Todor V Kantardzhiev, Mariana A Murdjeva
BACKGROUND: Production of Bla OXA-23, OXA-24, OXA-58 and hyperexpression of OXA-51 due to ISAba1 insertion sequence are the leading causes of carbapenem resistance in Acinetobacter baumannii. The loss of OprD transmembrane protein and the overexpression of some effl ux pumps are considered to be the main factors for carbapenem resistance in Pseudomonas aeruginosa whereas metallo-enzymes' production has a secondary role. AIM: Тo examine the carbapenem resistance due to carbapenemase production among clinically signifi cant Gram-negative non-fermenters from St George University hospital, Plovdiv: A...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29340455/central-venous-catheter-related-infections-in-patients-receiving-short-term-hemodialysis-therapy-incidence-associated-factors-and-microbiological-aspects
#9
Mayra Gonçalves Menegueti, Natália Cristina Betoni, Fernando Bellissimo-Rodrigues, Elen Almeida Romão
INTRODUCTION: Bloodstream infections are the second most common cause of death among patients on hemodialysis. This study aimed to evaluate the incidence of and risk factors associated with central venous catheter-related infections in patients undergoing hemodialysis, and to identify and characterize the type and antimicrobial susceptibility profiles of the primary microorganisms isolated during one year of follow-up. METHODS: A prospective cohort study was conducted in 2014 in a hemodialysis referral center...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340452/detection-of-multidrug-resistant-pseudomonas-aeruginosa-harboring-bla-ges-1-and-bla-ges-11-in-recife-brazil
#10
Valdemir Vicente da Silva Júnior, Laura Durão Ferreira, Lílian Rodrigues Alves, Adriane Borges Cabral, Paula Regina Luna de Araújo Jácome, Paulo Sérgio Ramos de Araújo, Ana Catarina de Souza Lopes, Maria Amélia Vieira Maciel
INTRODUCTION: Pseudomonas aeruginosa, an important pathogen globally, presents several resistance mechanisms. This study aimed to investigate the presence of bla GES in clinical isolates of Pseudomonas aeruginosa obtained from various clinical specimens from patients admitted to three different hospitals in Recife, Brazil. The Guiana extended spectrum beta-lactamase (GES) enzymes are responsible for conferring broad spectrum resistance to beta-lactam drugs, including the carbapenems. METHODS: A total of 100 carbapenem-resistant P...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340299/prospective-study-of-the-feasibility-of-point-of-care-testing-strategy-for-carbapenem-resistant-organism-detection
#11
Rahul Pannala, Bruce Baldwin, Vijay Aluru, Thomas E Grys, Jordan Holmes, Laurence J Miller, M Edwyn Harrison, Cuong C Nguyen, Fred C Tenover, David Persing, Douglas O Faigel
Background/aims:  In an investigator-initiated, prospective study, we evaluated the feasibility of a five-gene sequence point-of-care (POC) testing strategy (Xpert CARBA-R Assay, Cepheid Inc., Sunnyvale, CA, USA), compared to reference laboratory PCR (48 - 72 hours turnaround time, two gene sequences), in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and in a hospital outbreak investigation. Methods:  After informed consent, patients undergoing ERCP (September 2015 - April 2016, n = 191) at Mayo Clinic and potential hospital contacts (n = 9) of an index carbapenem-resistant organism (CRO)-positive inpatient were included...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29339388/combating-carbapenem-resistant-acinetobacter-baumannii-by-an-optimized-imipenem-plus-tobramycin-dosage-regimen-prospective-validation-via-hollow-fiber-infection-and-mathematical-modeling
#12
Cornelia B Landersdorfer, Rajbharan Yadav, Kate E Rogers, Tae Hwan Kim, Beom Soo Shin, John D Boyce, Roger L Nation, Jürgen B Bulitta
We aimed to prospectively validate an optimized combination dosage regimen against a clinical carbapenem-resistant Acinetobacter baumannii (CRAB; MICImipenem: 32mg/liter, MICTobramycin: 2mg/liter). Imipenem at constant concentrations (7.6, 13.4 and 23.3mg/liter, reflecting a range of clearances) was simulated in a 7-day hollow fiber infection model (inoculum ∼107.2 CFU/mL) with and without tobramycin (7mg/kg q24h, 0.5h infusions). While monotherapies achieved no killing or failed by 24h, this rationally optimized combination achieved >5 log10 bacterial killing and suppressed resistance...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29339296/silent-transmission-of-an-is1294b-deactivated-mcr-1-gene-with-inducible-colistin-resistance
#13
Kai Zhou, Qixia Luo, Qin Wang, Chen Huang, Haifeng Lu, Rossen W A John, Yonghong Xiao, Lanjuan Li
The global dissemination of the mobile colistin resistance mcr-1 is of special concern, as colistin is one of the last-resort antibiotics for the treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria. Here, we characterized an inactive form of mcr-1 in a fluoroquinolone-resistant and colistin-susceptible uropathogenic Escherichia coli isolate (ECO3347). The mcr-1 gene was deactivated by the insertion of a 1.7-Kb IS1294b element flanked by two tetramers (GTTC), and located on a 62-Kb pHNSHP45-like plasmid (p3347-mcr-1)...
January 12, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29337862/therapeutic-management-of-pseudomonas-aeruginosa-bloodstream-infection-non-susceptible-to-carbapenems-but-susceptible-to-old-cephalosporins-and-or-to-penicillins
#14
Ronit Zaidenstein, Asaf Miller, Ruthy Tal-Jasper, Hadas Ofer-Friedman, Menachem Sklarz, David E Katz, Tsillia Lazarovitch, Paul R Lephart, Bethlehem Mengesha, Oran Tzuman, Mor Dadon, Chen Daniel, Jacob Moran-Gilad, Dror Marchaim
It is unknown as to whether other beta-lactams can be used for bloodstream infections (BSI) resulting from Pseudomonas aeruginosa (PA) which are non-susceptible to one or more carbapenem. We conducted a retrospective cohort study at the Assaf Harofeh Medical Center (AHMC) from January 2010 to August 2014. Adult patients with PA-BSI non-susceptible to a group 2 carbapenem but susceptible to ceftazidime or piperacillin (with or without tazobactam), were enrolled. We compared the outcomes of patients who received an appropriate beta-lactam antibiotic ("cases") to those who received an appropriate non-beta-lactam antibiotic ("controls")...
January 16, 2018: Microorganisms
https://www.readbyqxmd.com/read/29336873/optimization-of-novel-monobactams-with-activity-against-carbapenem-resistant-enterobacteriaceae-identification-of-lys228
#15
Folkert Reck, Alun Bermingham, Johanne Blais, Vladimir Capka, Taryn Cariaga, Anthony Casarez, Richard Colvin, Charles R Dean, Alex Fekete, Wanben Gong, Ellie Growcott, Hongqiu Guo, Adriana K Jones, Cindy Li, Fengxia Li, Xiaodong Lin, Mika Lindvall, Sara Lopez, David McKenney, Louis Metzger, Heinz E Moser, Ramadevi Prathapam, Dita Rasper, Patrick Rudewicz, Vijay Sethuraman, Xiaoyu Shen, Jacob Shaul, Robert L Simmons, Kyuto Tashiro, Dazhi Tang, Meiliana Tjandra, Nancy Turner, Tsuyoshi Uehara, Charles Vitt, Steven Whitebread, Aregahegn Yifru, Xu Zang, Qingming Zhu
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clinical utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clinical isolates...
January 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29335025/prevalence-of-a-carbapenem-resistance-gene-kpc-vancomycin-resistance-genes-van-a-b-and-a-methicillin-resistance-gene-meca-in-hospital-and-municipal-sewage-in-a-southwestern-province-of-saudi-arabia
#16
Vinod Kumar Basode, Ahmed Abdulhaq, Mohammed Uthman A Alamoudi, Hassan Mohammad Tohari, Waleed Ali Quhal, Aymen Mohammed Madkhali, Yahya Hasan Hobani, Almonther Abdullah Hershan
OBJECTIVE: According to the World Health Organization, the increasing antibiotic resistance of pathogens is one of the most important threats to human health. Prevalence of a carbapenem-resistance gene (KPC), vancomycin-resistance genes (van A/B) and a methicillin-resistance gene (mecA) in hospital and municipal sewages will be potential threat to public health. RESULTS: Vancomycin-resistance genes were detected in the sewage of community tank-II, sewage tank of the tertiary and general hospital...
January 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29332105/the-emergence-of-carbapenem-resistant-klebsiella-pneumoniae-isolates-producing-oxa-48-and-ndm-in-the-southern-asir-province-saudi-arabia
#17
Ibrahim A Al-Zahrani, Bander A Alsiri
To identify the prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) and the most common types of cabapenemases among CRKP in the Southern (Asir) province hospitals, Saudi Arabia. Methods: The cross-sectional study was conducted between late April and September in 2015. A total of 54 Klebsiella pneumoniae (K. pneumoniae) isolates with reduced sensitivity to carbapenems were obtained from various clinical specimens of the 2 largest hospitals in the Southern province. Minimum inhibitory concentrations (MICs) of carbapenems were confirmed using E-test...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29331155/performance-of-a-novel-antipseudomonal-antibiotic-consumption-metric-among-academic-medical-centers-in-the-united-states
#18
John Daniel Markley, Amy L Pakyz, Roy T Sabo, Gonzalo Bearman, Samuel F Hohmann, Michael P Stevens
A metric was developed to identify hospital proportion of carbapenem consumption (PoCC) among antipseudomonal antibiotics. The PoCC varied significantly among academic medical centers by Census Bureau geographic division after adjusting for patient mix. This metric may be useful in identifying disproportionate carbapenem use and potential carbapenem overuse. Infect Control Hosp Epidemiol 2018;1-4.
January 14, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29327131/renal-vein-thrombosis-complicating-severe-acute-pyelonephritis-with-renal-abscesses-and-associated-bacteraemia-caused-by-extended-spectrum-beta-lactamase-producing-escherichia-coli
#19
Stelios F Assimakopoulos, Pantelis Kraniotis, Charalambos Gogos, Markos Marangos
Acute pyelonephritis might be complicated by the formation of renal and perirenal abscesses and very rarely by renal vein thrombosis, which is a life-threatening condition. The main causative agents of acute pyelonephritis are enterobacteriaceae with the incidence of extended-spectrum beta-lactamase (ESBL)-producing strains increasing worldwide. We present the case of a 71-year-old Greek man with history of diabetes mellitus and recent hospitalization, who suffered from severe pyelonephritis with renal abscesses formation and associated bacteraemia caused by ESBL-producing Escherichia coli, complicated by extensive thrombosis of the ipsilateral renal vein and its branches, protruding also in the inferior venal cava...
January 11, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29324651/incidence-microbiological-profile-and-risk-factors-of-healthcare-associated-infections-in-intensive-care-units-a-10-year-observation-in-a-provincial-hospital-in-southern-poland
#20
Małgorzata Kołpa, Marta Wałaszek, Agnieszka Gniadek, Zdzisław Wolak, Wiesław Dobroś
Healthcare-associated infections (HAIs) occurring in patients treated in an intensive care unit (ICU) are serious complications in the treatment process. Aetiological factors of these infections can have an impact on treatment effects, treatment duration and mortality. The aim of the study was to determine the prevalence and microbiological profile of HAIs in patients hospitalized in an ICU over a span of 10 years. The active surveillance method was used to detect HAIs in adult patients who spent over 48 h in a general ICU ward located in southern Poland between 2007 and 2016...
January 11, 2018: International Journal of Environmental Research and Public Health
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