Mohammad Asim, Abdul Malik, Manash P Sarma, Sunil K Polipalli, Nargis Begum, Istaq Ahmad, Luqman A Khan, S A Husain, Naseem Akhtar, Sajid Husain, L Thayumanavan, Rajiv Singla, P Kar
The study aims to characterize mutations of the HBV genome involving BCP, Precore/core and X regions and also defines HBV genotypes in patients of hepatocellular carcinoma (HCC). The study involved 150 HBV-related HCC cases and 136 HBV-related chronic liver disease patients without HCC as controls. HBV DNA was subjected to mutational analysis using SSCP technique, genotyping by RFLP, and direct nucleotide sequencing. HBV DNA was found in 58.7% (88/150) of the HCC cases and 74.3% (101/136) of controls. HBV mutants were observed in 44...
July 2010: Journal of Medical Virology