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https://www.readbyqxmd.com/read/28444828/labeling-and-defining-severe-and-enduring-anorexia-nervosa-a-systematic-review-and-critical-analysis
#1
REVIEW
Catherine Broomfield, Kristin Stedal, Stephen Touyz, Paul Rhodes
OBJECTIVE: With anorexia nervosa (AN) having various presentations, attention has been directed towards particularly durable forms of the condition in both research and clinical contexts. A major hindrance in terms of advancing the field is the inconsistent labeling and defining of this subgroup. This has two implications; first, the inconsistent recruitment of participants when researching this sample, and second, the misdiagnosing of patients who may or may not have a durable course of the disease...
April 25, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28442659/diagnostic-accuracy-of-endocardial-to-epicardial-myocardial-blood-flow-ratio-for-the-detection-of-significant-coronary-artery-disease-with-dynamic-myocardial-perfusion-dual-source-computed-tomography
#2
Yoshitaka Goto, Kakuya Kitagawa, Mio Uno, Shiro Nakamori, Tatsuro Ito, Naoki Nagasawa, Kaoru Dohi, Hajime Sakuma
BACKGROUND: Previous dynamic stress computed tomography perfusion (CTP) studies used absolute myocardial blood flow (MBF in mL/100 g/min) as a threshold to discriminate flow-limiting coronary artery disease (CAD), but absolute MBF can be vary because of multiple factors. The aim of this study was to compare the diagnostic performance of absolute MBF and the transmural perfusion ratio (TPR) for the detection of flow-limiting CAD, and to clarify the influence of CT delayed enhancement (CTDE) on the diagnostic performance of CTP...
April 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28441176/long-term-nitrite-inhalant-exposure-and-cancer-risk-in-msm
#3
Anupriya Dutta, Hajime Uno, Alex Holman, David R Lorenz, Steven M Wolinsky, Dana Gabuzda
OBJECTIVES: Nitrite inhalants (poppers) are commonly used recreational drugs among MSM and were previously associated with elevated rates of high-risk sexual behavior, HIV and human herpesvirus type 8 (HHV-8) seroconversion, and transient immunosuppressive effects in experimental models. Whether long-term popper use is associated with cancer risk among MSM in the HAART era is unclear. DESIGN: Prospective cohort study of cancer risk in 3223 HIV-infected and uninfected MSM in the Multicenter AIDS Cohort Study from 1996-2010...
May 15, 2017: AIDS
https://www.readbyqxmd.com/read/28436281/terfenadine-t-butyl-hydroxylation-catalyzed-by-human-and-marmoset-cytochrome-p450-3a-and-4f-enzymes-in-livers-and-small-intestines
#4
Shotaro Uehara, Yukako Yuki, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
1. Roles of human cytochrome P450 (P450) 3A4 in oxidation of an antihistaminic drug terfenadine have been previously investigated in association with terfenadine-ketoconazole interaction. Several antihistamine drugs have been recently identified as substrates for multiple P450 enzymes. In this study, overall roles of P450 3A4, 2J2, and 4F12 enzymes in terfenadine t-butyl hydroxylation were investigated in small intestines and livers from humans, marmosets, and/or cynomolgus monkeys. 2. Human liver microsomes and liver and small intestine microsomes from marmosets and cynomolgus monkeys effectively mediated terfenadine t-butyl hydroxylation...
April 22, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28434977/starch-fueled-microbial-fuel-cells-by-two-step-and-parallel-fermentation-using-shewanella-oneidensis-mr-1-and-streptococcus-bovis-148
#5
Megumi Uno, Nichanan Phansroy, Yuji Aso, Hitomi Ohara
Shewanella oneidensis MR-1 generates electricity from lactic acid, but cannot utilize starch. On the other hand, Streptococcus bovis 148 metabolizes starch and produces lactic acid. Therefore, two methods were trialed for starch-fueled microbial fuel cell (MFC) in this study. In electric generation by two-step fermentation (EGT) method, starch was first converted to lactic acid by S. bovis 148. The S. bovis 148 were then removed by centrifugation, and the fermented broth was preserved for electricity generation by S...
April 20, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28434656/an-overview-of-eu-and-usa-intestinal-transplant-current-activity
#6
A Lauro, F Panaro, K R Iyer
AIM OF THE STUDY: To report the current activity of intestinal transplantation in Europe (EU) and Unites States of America (USA), underlining outcomes in the last 5 years and discussing possible trends. PATIENTS AND METHODS: Data review of results was performed through analysis of ITR and UNOS registries, Eurotransplant and newsletter transplant reports, congress abstracts, international published literature, personal communications and hospital web sites. RESULTS: The absence in Europe of a sole organization collecting donors and the presence of many low-volume centers (less than 5 cases/year) makes the difference with USA: in the last 5 years (2010-2014), 222 intestinal/multivisceral transplants have been performed in EU countries (most of them in the UK), while in USA, the number of transplants achieved 634 procedures in the same period of time...
April 20, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28425018/hepatocellular-carcinoma-and-liver-transplantation-changing-patterns-and-practices
#7
REVIEW
Nicole E Rich, Neehar D Parikh, Amit G Singal
Benefits of liver transplantation (LT) for patients with hepatocellular carcinoma (HCC) are well established. However, there is debate regarding optimal and equitable selection of patients best served by LT, particularly in the face of limited organ availability. Herein, we discuss topics regarding LT selection criteria for patients with HCC. Recent change in UNOS policy currently mandates a 6-month observation period prior to priority listing and institutes a cap of 34 MELD exception points for patients with HCC...
April 19, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28422550/evaluation-of-the-diagnostic-accuracy-of-ubc-%C3%A2-rapid-in-bladder-cancer-a-swedish-multicentre-study
#8
Johan Styrke, Helene Henriksson, Börje Ljungberg, Mudhar Hasan, Ingrid Silfverberg, Roland Einarsson, Per-Uno Malmström, Amir Sherif
OBJECTIVE: The aim of this study was to determine the diagnostic accuracy of UBC(®) Rapid - a urine-based marker for bladder cancer - in patients with bladder cancer and controls, and to compare the test results across risk groups. MATERIALS AND METHODS: This prospective phase II study was conducted at four Swedish hospitals. UBC Rapid was evaluated in four groups: A, newly diagnosed bladder cancer (n = 94); B, follow-up of non-muscle-invasive bladder cancer (n = 75); C, benign urinary tract diseases (n = 51); and D, healthy controls (n = 50)...
April 19, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28421894/how-learning-analytics-can-early-predict-under-achieving-students-in-a-blended-medical-education-course
#9
Mohammed Saqr, Uno Fors, Matti Tedre
AIM: Learning analytics (LA) is an emerging discipline that aims at analyzing students' online data in order to improve the learning process and optimize learning environments. It has yet un-explored potential in the field of medical education, which can be particularly helpful in the early prediction and identification of under-achieving students. The aim of this study was to identify quantitative markers collected from students' online activities that may correlate with students' final performance and to investigate the possibility of predicting the potential risk of a student failing or dropping out of a course...
April 19, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28420338/review-and-evaluation-of-performance-measures-for-survival-prediction-models-in-external-validation-settings
#10
M Shafiqur Rahman, Gareth Ambler, Babak Choodari-Oskooei, Rumana Z Omar
BACKGROUND: When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have been proposed, there is only limited guidance regarding their use in the context of model validation. This paper reviewed and evaluated a wide range of performance measures to provide some guidelines for their use in practice. METHODS: An extensive simulation study based on two clinical datasets was conducted to investigate the performance of the measures in external validation settings...
April 18, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28420070/lower-kidney-allograft-survival-in-african-americans-compared-to-hispanic-americans-with-lupus
#11
M L Gonzalez-Suarez, G Contreras
Background and objective African-Americans and Hispanic-Americans with lupus are the two most common minority groups who receive kidney transplants in the USA. It is unknown if African-Americans and Hispanic-Americans with lupus have similar outcomes after kidney transplantation. In this study, we assessed whether African-Americans compared to Hispanic-Americans have worse kidney allograft survival after risk factors of rejection and other prognostic factors were matched between both groups. Methods Out of 1816 African-Americans and 901 Hispanic-Americans with lupus, who received kidney transplants between 1987 and 2006 and had complete records in the UNOS program, 478 pairs were matched in 16 baseline predictors and follow-up time employing a predicted probability of group membership...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28415218/biodiversity-extinctions-and-evolution-of-ecosystems-with-shared-resources
#12
Vladimir Kozlov, Sergey Vakulenko, Uno Wennergren
We investigate the formation of stable ecological networks where many species share the same resource. We show that such a stable ecosystem naturally occurs as a result of extinctions. We obtain an analytical relation for the number of coexisting species, and we find a relation describing how many species that may become extinct as a result of a sharp environmental change. We introduce a special parameter that is a combination of species traits and resource characteristics used in the model formulation. This parameter describes the pressure on the system to converge, by extinctions...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28412533/print-specific-n170-involves-multiple-subcomponents-for-japanese-hiragana
#13
Tomoki Uno, Yasuko Okumura, Tetsuko Kasai
Print-specific N170 in event-related potentials is generally considered to reflect relatively automatic processing for letter strings, which is crucial for fluent reading. However, our previous studies demonstrated that print-specific N170 for transparent Japanese Hiragana script consists of at least two subcomponents under rapid stimulus presentation: an attention-related left-lateralized N170 and a bilateral N170 associated with more automatic orthographic processes (Okumura, Kasai & Murohashi, 2014, 2015)...
April 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28408622/a-host-dependent-prognostic-model-for-elderly-patients-with-diffuse-large-b-cell-lymphoma
#14
Katsuhiro Miura, Jun Konishi, Takaaki Miyake, Masanori Makita, Atsuko Hojo, Yasufumi Masaki, Masatoshi Uno, Jun Ozaki, Chikamasa Yoshida, Daigo Niiya, Koichi Kitazume, Yoshinobu Maeda, Jun Takizawa, Rika Sakai, Tomofumi Yano, Kazuhiko Yamamoto, Kazutaka Sunami, Yasushi Hiramatsu, Kazutoshi Aoyama, Hideki Tsujimura, Jun Murakami, Yoshihiro Hatta, Masatoshi Kanno
BACKGROUND: Decision-making models for elderly patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) are in great demand. PATIENTS AND METHODS: The Society of Lymphoma Treatment in Japan (SoLT-J), in collaboration with the West-Japan Hematology and Oncology Group (West-JHOG), collected and retrospectively analyzed the clinical records of ≥65-year-old patients with DLBCL treated with R-CHOP from 19 sites across Japan to build an algorithm that can stratify adherence to R-CHOP...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28403575/comparison-of-two-equivalent-meld-scores-for-hepatocellular-carcinoma-patients-using-data-from-the-united-network-for-organ-sharing-liver-transplant-waiting-list-registry
#15
Sarah K Alver, Douglas J Lorenz, Kenneth Washburn, Michael R Marvin, Guy N Brock
Hepatocellular carcinoma (HCC) patients have been advantaged on the liver transplant waiting list within the United States, and a 6-month delay and exception point cap have recently been implemented to address this disparity. An alternative approach to prioritization is an HCC-specific scoring model such as the MELD Equivalent (MELDEQ ) and the mixed new deMELD. Using data on adult patients added to the UNOS waitlist between 9/30/2009 and 6/30/14, we compared projected dropout and transplant probabilities for HCC patients under these two models...
April 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28400055/oil-spill-off-the-coast-of-guimaras-island-philippines-distributions-and-changes-of-polycyclic-aromatic-hydrocarbons-in-shellfish
#16
Seiichi Uno, Emiko Kokushi, Nathaniel C Añasco, Takenori Iwai, Kazuki Ito, Jiro Koyama
The sinking of the Solar 1 tanker caused serious heavy oil pollution around Guimaras Island, Philippines. In the present study, variations of parent polycyclic aromatic hydrocarbons (PAHs) and alkylated PAHs (alkPAHs) in some shellfish were investigated around Guimaras Island and other small islands from 3months to 5years after the spill. The total PAHs and alkPAHs in shellfish were detected in high concentrations at 448 and 33,666ng/g dry weight, respectively, in November 2006. The concentrations of alkPAHs gradually decreased, while the parent PAHs in shellfish degraded more slowly than the alkPAHs, which was likely due to the persistent characteristics of PAHs...
April 8, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28398495/a-histological-study-of-fulminant-type-1-diabetes-mellitus-related-to-human-cytomegalovirus-reactivation
#17
Sho Yoneda, Akihisa Imagawa, Kenji Fukui, Sae Uno, Junji Kozawa, Makoto Sakai, Toshiki Yumioka, Hiromi Iwahashi, Iichiro Shimomura
Context: Fulminant type 1 diabetes mellitus (T1DM) is thought to be partly caused by virus infection. Objective: This study investigated the mechanism of β cell destruction in fulminant T1DM after drug-induced hypersensitivity syndrome (DIHS). Methods: We determined the localization of viruses of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV), and the expression of interferon regulatory factor 3 (IRF3) and viral receptors of Z DNA binding protein 1 (ZBP1) and retinoic acid-inducible gene I (RIG-I), together with inflammatory cells by immunohistochemistry of pancreas from an autopsy fulminant T1DM patient with DIHS or seven subjects with normal glucose tolerance who underwent pancreatectomy...
April 10, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28398408/-uno-studio-sul-processo-di-riconciliazione-terapeutica-del-paziente-in-un-ospedale-oncologico
#18
Frida Gorreja, Vera Damuzzo, Umberto Gallo, Alberto Russi, Francesco Lo Re, Susanna Ciampalini, Lucia Guidotti, Marta Serena, Angelo Claudio Palozzo
Riassunto. Obiettivi. Lo scopo di questo studio è stato valutare l'impatto della riconciliazione terapeutica nella pratica clinica dal punto di vista del farmacista ospedaliero. Metodi. È stata condotta un'indagine riguardante i trattamenti farmacologici assunti dai pazienti al momento dell'ammissione e della dimissione in un ospedale oncologico. Il farmacista ha inserito i dati raccolti in un supporto informatico che, impiegando i criteri di STOPP (Screening Tool of Older Persons' Potentially Inappropriate Prescriptions) e il database Micromedex™, utile per valutare le interazioni farmacologiche, ha prodotto automaticamente un report che indicava le possibili incongruenze farmacologiche...
March 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28398266/design-and-implementation-of-an-intelligent-windowsill-system-using-smart-handheld-device-and-fuzzy-microcontroller
#19
Jing-Min Wang, Ming-Ta Yang, Po-Lin Chen
With the advance of science and technology, people have a desire for convenient and comfortable living. Creating comfortable and healthy indoor environments is a major consideration for designing smart homes. As handheld devices become increasingly powerful and ubiquitous, this paper proposes an innovative use of smart handheld devices (SHD), using MIT App Inventor and fuzzy control, to perform the real-time monitoring and smart control of the designed intelligent windowsill system (IWS) in a smart home. A compact weather station that consists of environment sensors was constructed in the IWS for measuring of indoor illuminance, temperature-humidity, carbon dioxide (CO₂) concentration and outdoor rain and wind direction...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28398113/second-look-resection-for-primary-stage-t1-bladder-cancer-a-population-based-study
#20
Oliver Patschan, Sten Holmäng, Abolfazl Hosseini, Georg Jancke, Fredrik Liedberg, Börje Ljungberg, Per-Uno Malmström, Johan Rosell, Staffan Jahnson
OBJECTIVE: This study aimed to evaluate the use of second-look resection (SLR) in stage T1 bladder cancer (BC) in a population-based Swedish cohort. MATERIALS AND METHODS: All patients diagnosed with stage T1 BC in 2008-2009 were identified in the Swedish National Registry for Urinary Bladder Cancer. Registry data on TNM stage, grade, primary treatment and pathological reports from the SLR performed within 8 weeks of the primary transurethral resection were validated against patient charts...
April 11, 2017: Scandinavian Journal of Urology
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