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https://www.readbyqxmd.com/read/29781049/effects-of-vitamin-k-epoxide-reductase-complex-1-gene-polymorphisms-on-warfarin-control-in-japanese-patients-with-left-ventricular-assist-devices-lvad
#1
Kazuki Nakagita, Kyoichi Wada, Yutaro Mukai, Takaya Uno, Ryoji Nishino, Sachi Matsuda, Hiromi Takenaka, Nobue Terakawa, Akira Oita, Mitsutaka Takada
PURPOSE: This study aimed to investigate relationships between times in therapeutic range (TTR) or warfarin sensitivity indexes (WSI) and VKORC1-1639G>A and CYP2C9 polymorphisms in patients with left ventricular assist devices (LVAD). METHODS: Severe heart failure patients who received LVAD from January 1, 2013 to October 31, 2017 were recruited. Relationships between TTR or WSI and VKORC1-1639G>A and CYP2C9 gene polymorphisms were investigated immediately after LVAD implantation (period 1) and immediately prior to hospital discharge (period 2)...
May 21, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29775706/purification-and-characterization-of-an-organic-solvent-tolerant-and-detergent-stable-lipase-from-haloferax-mediterranei-cncmm-50101
#2
Siham Akmoussi-Toumi, Souad Khemili-Talbi, Imen Ferioune, Salima Kebbouche-Gana
The present study investigates the purification and biochemical characterization of an extracellular lipase (HML) from Haloarchaea Haloferax mediterranei strain ATS1, isolated from the Sebkha (Medea, Algeria). The pure protein was obtained with ammonium sulfate precipitation (40-70%)-dialysis and UNO Q-6 FPLC, and characterized biochemically. Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/MS) analysis revealed that the purified enzyme was a monomer, with a molecular mass of 45,011...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29774622/pediatric-marginal-donor-hearts-trends-in-us-national-use-2005-2014
#3
Adam K Morrison, Charitha Gowda, Dmitry Tumin, Christina M Phelps, Don Hayes, Joseph Tobias, Robert J Gajarski, Deipanjan Nandi
Pediatric patients awaiting heart transplant face high mortality rates due to donor organ shortages, including non-use of marginal donor hearts. We examined national trends in pediatric marginal donor heart use over time. UNOS data were queried for heart donors <18 years from 2005 to 2014. The proportion of donor hearts considered marginal was determined using previously cited marginal characteristics: left ventricular ejection fraction (LVEF) <50%, use of ≥2 inotropes, cerebrovascular death, CDC high-risk status, and eGFR < 30 mL/min/1...
May 17, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29756910/search-for-high-mass-resonances-decaying-to-%C3%AF-%C3%AE-in-pp-collisions-at-sqrt-s-13-tev-with-the-atlas-detector
#4
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, M Antonelli, D J Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, E M Asimakopoulou, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, B Axen, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, J T Baines, M Bajic, O K Baker, P J Bakker, D Bakshi Gupta, E M Baldin, P Balek, F Balli, W K Balunas, E Banas, A Bandyopadhyay, Sw Banerjee, A A E Bannoura, L Barak, W M Barbe, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J T Barkeloo, T Barklow, N Barlow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, H C Beck, K Becker, M Becker, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, C Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, T Bisanz, C Bittrich, D M Bjergaard, J E Black, K M Black, R E Blair, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, A J Bozson, J Bracinik, N Brahimi, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, D L Briglin, T M Bristow, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, D Büscher, V Büscher, E Buschmann, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, G Cabras, S Cabrera Urbán, D Caforio, H Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, Y Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, M Casolino, D W Casper, R Castelijn, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C Chen, H Chen, J Chen, J Chen, S Chen, S Chen, X Chen, Y Chen, Y-H Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, I Chiu, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, D Cinca, V Cindro, I A Cioară, A Ciocio, F Cirotto, Z H Citron, M Citterio, A Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, F Conventi, A M Cooper-Sarkar, F Cormier, K J R Cormier, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, J Crane, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, M Curatolo, J Cúth, S Czekierda, P Czodrowski, G D'amen, S D'Auria, L D'eramo, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, M F Daneri, N P Dang, N S Dann, M Danninger, V Dao, G Darbo, S Darmora, O Dartsi, A Dattagupta, T Daubney, W Davey, C David, T Davidek, D R Davis, E Dawe, I Dawson, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, M Del Gaudio, J Del Peso, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Della Pietra, D Della Volpe, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Micco, R Di Nardo, K F Di Petrillo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, T Dias do Vale, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, E Dreyer, T Dreyer, M Dris, Y Du, J Duarte-Campderros, F Dubinin, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, C Dulsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, S Errede, M Escalier, C Escobar, B Esposito, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Fakhrutdinov, S Falciano, P J Falke, S Falke, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, M Feickert, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L M Flores, L R Flores Castillo, N Fomin, G T Forcolin, A Formica, F A Förster, A Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, B Freund, W S Freund, D Froidevaux, J A Frost, C Fukunaga, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, P Gadow, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, R Gamboa Goni, K K Gan, S Ganguly, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, K Gasnikova, A Gaudiello, G Gaudio, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, G Geßner, S Ghasemi, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, S M Gibson, M Gignac, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, M Giulini, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, R Goncalves Gama, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, S González de la Hoz, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, B Gorini, E Gorini, A Gorišek, A T Goshaw, C Gössling, M I Gostkin, C A Gottardo, C R Goudet, D Goujdami, A G Goussiou, N Govender, C Goy, E Gozani, I Grabowska-Bold, P O J Gradin, E C Graham, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, P M Gravila, C Gray, H M Gray, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, A Grummer, L Guan, W Guan, J Guenther, A Guerguichon, F Guescini, D Guest, O Gueta, R Gugel, B Gui, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, W Guo, Y Guo, R Gupta, S Gurbuz, G Gustavino, B J Gutelman, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, C Guyot, M P Guzik, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, S Hageböck, M Hagihara, H Hakobyan, M Haleem, J Haley, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A Hamilton, G N Hamity, K Han, L Han, S Han, K Hanagaki, M Hance, D M Handl, B Haney, R Hankache, P Hanke, E Hansen, J B Hansen, J D Hansen, M C Hansen, P H Hansen, K Hara, A S Hard, T Harenberg, S Harkusha, P F Harrison, N M Hartmann, Y Hasegawa, A Hasib, S Hassani, S Haug, R Hauser, L Hauswald, L B Havener, M Havranek, C M Hawkes, R J Hawkings, D Hayden, C Hayes, C P Hays, J M Hays, H S Hayward, S J Haywood, M P Heath, V Hedberg, L Heelan, S Heer, K K Heidegger, S Heim, T Heim, B Heinemann, J J Heinrich, L Heinrich, C Heinz, J Hejbal, L Helary, A Held, S Hellesund, S Hellman, C Helsens, R C W Henderson, Y Heng, S Henkelmann, A M Henriques Correia, G H Herbert, H Herde, V Herget, Y Hernández Jiménez, H Herr, G Herten, R Hertenberger, L Hervas, T C Herwig, G G Hesketh, N P Hessey, J W Hetherly, S Higashino, E Higón-Rodriguez, K Hildebrand, E Hill, J C Hill, K H Hiller, S J Hillier, M Hils, I Hinchliffe, M Hirose, D Hirschbuehl, B Hiti, O Hladik, D R Hlaluku, X Hoad, J Hobbs, N Hod, M C Hodgkinson, A Hoecker, M R Hoeferkamp, F Hoenig, D Hohn, D Hohov, T R Holmes, M Holzbock, M Homann, S Honda, T Honda, T M Hong, B H Hooberman, W H Hopkins, Y Horii, A J Horton, L A Horyn, J-Y Hostachy, A Hostiuc, S Hou, A Hoummada, J Howarth, J Hoya, M Hrabovsky, J Hrdinka, I Hristova, J Hrivnac, T Hryn'ova, A Hrynevich, P J Hsu, S-C Hsu, Q Hu, S Hu, Y Huang, Z Hubacek, F Hubaut, M Huebner, F Huegging, T B Huffman, E W Hughes, M Huhtinen, R F H Hunter, P Huo, A M Hupe, N Huseynov, J Huston, J Huth, R Hyneman, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, Z Idrissi, P Iengo, R Ignazzi, O Igonkina, R Iguchi, T Iizawa, Y Ikegami, M Ikeno, D Iliadis, N Ilic, F Iltzsche, G Introzzi, M Iodice, K Iordanidou, V Ippolito, M F Isacson, N Ishijima, M Ishino, M Ishitsuka, C Issever, S Istin, F Ito, J M Iturbe Ponce, R Iuppa, A Ivina, H Iwasaki, J M Izen, V Izzo, S Jabbar, P Jacka, P Jackson, R M Jacobs, V Jain, G Jakel, K B Jakobi, K Jakobs, S Jakobsen, T Jakoubek, D O Jamin, D K Jana, R Jansky, J Janssen, M Janus, P A Janus, G Jarlskog, N Javadov, T Javůrek, M Javurkova, F Jeanneau, L Jeanty, J Jejelava, A Jelinskas, P Jenni, J Jeong, C Jeske, S Jézéquel, H Ji, J Jia, H Jiang, Y Jiang, Z Jiang, S Jiggins, F A Jimenez Morales, J Jimenez Pena, S Jin, A Jinaru, O Jinnouchi, H Jivan, P Johansson, K A Johns, C A Johnson, W J Johnson, K Jon-And, R W L Jones, S D Jones, S Jones, T J Jones, J Jongmanns, P M Jorge, J Jovicevic, X Ju, J J Junggeburth, A Juste Rozas, A Kaczmarska, M Kado, H Kagan, M Kagan, T Kaji, E Kajomovitz, C W Kalderon, A Kaluza, S Kama, A Kamenshchikov, L Kanjir, Y Kano, V A Kantserov, J Kanzaki, B Kaplan, L S Kaplan, D Kar, K Karakostas, N Karastathis, M J Kareem, E Karentzos, S N Karpov, Z M Karpova, V Kartvelishvili, A N Karyukhin, K Kasahara, L Kashif, R D Kass, A Kastanas, Y Kataoka, C Kato, A Katre, J Katzy, K Kawade, K Kawagoe, T Kawamoto, G Kawamura, E F Kay, V F Kazanin, R Keeler, R Kehoe, J S Keller, E Kellermann, J J Kempster, J Kendrick, O Kepka, B P Kerševan, S Kersten, R A Keyes, M Khader, F Khalil-Zada, A Khanov, A G Kharlamov, T Kharlamova, A Khodinov, T J Khoo, V Khovanskiy, E Khramov, J Khubua, S Kido, M Kiehn, C R Kilby, H Y Kim, S H Kim, Y K Kim, N Kimura, O M Kind, B T King, D Kirchmeier, J Kirk, A E Kiryunin, T Kishimoto, D Kisielewska, V Kitali, O Kivernyk, E Kladiva, T Klapdor-Kleingrothaus, M H Klein, M Klein, U Klein, K Kleinknecht, P Klimek, A Klimentov, R Klingenberg, T Klingl, T Klioutchnikova, F F Klitzner, E-E Kluge, P Kluit, S Kluth, E Kneringer, E B F G Knoops, A Knue, A Kobayashi, D Kobayashi, T Kobayashi, M Kobel, M Kocian, P Kodys, T Koffas, E Koffeman, N M Köhler, T Koi, M Kolb, I Koletsou, T Kondo, N Kondrashova, K Köneke, A C König, T Kono, R Konoplich, N Konstantinidis, B Konya, R Kopeliansky, S Koperny, K Korcyl, K Kordas, A Korn, I Korolkov, E V Korolkova, O Kortner, S Kortner, T Kosek, V V Kostyukhin, A Kotwal, A Koulouris, A Kourkoumeli-Charalampidi, C Kourkoumelis, E Kourlitis, V Kouskoura, A B Kowalewska, R Kowalewski, T Z Kowalski, C Kozakai, W Kozanecki, A S Kozhin, V A Kramarenko, G Kramberger, D Krasnopevtsev, M W Krasny, A Krasznahorkay, D Krauss, J A Kremer, J Kretzschmar, K Kreutzfeldt, P Krieger, K Krizka, K Kroeninger, H Kroha, J Kroll, J Kroll, J Kroseberg, J Krstic, U Kruchonak, H Krüger, N Krumnack, M C Kruse, T Kubota, S Kuday, J T Kuechler, S Kuehn, A Kugel, F Kuger, T Kuhl, V Kukhtin, R Kukla, Y Kulchitsky, S Kuleshov, Y P Kulinich, M Kuna, T Kunigo, A Kupco, T Kupfer, O Kuprash, H Kurashige, L L Kurchaninov, Y A Kurochkin, M G Kurth, E S Kuwertz, M Kuze, J Kvita, T Kwan, A La Rosa, J L La Rosa Navarro, L La Rotonda, F La Ruffa, C Lacasta, F Lacava, J Lacey, D P J Lack, H Lacker, D Lacour, E Ladygin, R Lafaye, B Laforge, S Lai, S Lammers, W Lampl, E Lançon, U Landgraf, M P J Landon, M C Lanfermann, V S Lang, J C Lange, R J Langenberg, A J Lankford, F Lanni, K Lantzsch, A Lanza, A Lapertosa, S Laplace, J F Laporte, T Lari, F Lasagni 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Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H Yang, H Yang, S Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C Young, C J S Young, J Yu, J Yu, X Yue, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, M Zgubič, D Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A search for high-mass resonances decaying to τν using proton-proton collisions at sqrt[s]=13  TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1  fb^{-1}. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W^{'} bosons with masses less than 3...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29752005/large-mammal-diets-and-paleoecology-across-the-oldowan-acheulean-transition-at-olduvai-gorge-tanzania-from-stable-isotope-and-tooth-wear-analyses
#5
Kevin T Uno, Florent Rivals, Faysal Bibi, Michael Pante, Jackson Njau, Ignacio de la Torre
The well-dated Pleistocene sediments at Olduvai Gorge have yielded a rich record of hominin fossils, stone tools, and vertebrate faunal remains that, taken together, provide insight to hominin behavior and paleoecology. Since 2008, the Olduvai Geochronology and Archaeology Project (OGAP) has undertaken extensive excavations in Bed II that have yielded a large collection of early Pleistocene stone tools and fossils. The strata of Lower, Middle and Upper Bed II at Olduvai Gorge capture the critical transition from Oldowan to Acheulean technology and therefore provide an opportunity to explore the possible role of biotic and abiotic change during the transition...
May 8, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29748209/tas6417-a-novel-epidermal-growth-factor-receptor-inhibitor-targeting-exon-20-insertion-mutations
#6
Shinichi Hasako, Miki Terasaka, Naomi Abe, Takao Uno, Hirokazu Ohsawa, Akihiro Hashimoto, Ryoto Fujita, Kenji Tanaka, Takashige Okayama, Renu Wadhwa, Kazutaka Miyadera, Yoshimi Aoyagi, Kazuhiko Yonekura, Kenichi Matsuo
Activating mutations in the epidermal growth factor receptor (EGFR) gene are important targets in cancer therapy because they are key drivers of non-small-cell lung cancer (NSCLC). Whereas almost all common EGFR mutations, such as exon 19 deletions and the L858R point mutation in exon 21, are sensitive to EGFR-tyrosine kinase inhibitor (TKI) therapies, NSCLC driven by EGFR exon 20 insertion mutations is associated with poor clinical outcomes due to dose-limiting toxicity, demonstrating the need for a novel therapy...
May 10, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29741971/impact-of-sleeping-altitude-on-symptoms-of-acute-mountain-sickness-on-mt-fuji
#7
Masahiro Horiuchi, Tadashi Uno, Junko Endo, Yoko Handa, Tatsuya Hasegawa
Horiuchi, Masahiro, Tadashi Uno, Junko Endo, Yoko Handa, and Tatsuya Hasegawa. Impact of sleeping altitude on symptoms of acute mountain sickness on Mt. Fuji. High Alt Med Biol. 00:000-000, 2018. AIMS: We sought to investigate the factors influencing acute mountain sickness (AMS) on Mt. Fuji in Japan, in particular, to assess the effects of sleeping altitude, by means of a questionnaire survey. This study involved 1932 participants who climbed Mt. Fuji, and obtained information regarding sex, age, and whether participants stayed at the mountain lodges...
May 9, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29733066/de-las-primeras-iniciativas-de-medicina-laboral-en-m%C3%A3-xico-el-hospital-de-mineros-de-real-del-monte
#8
José Luis Gómez, Carlos Agustín Rodríguez-Paz
A pesar de la legislación de Otto von Bismarck (1815-1898) sobre derechos de seguridad social formulada en 1883 en Alemania donde se señala que es deber del Estado promover el bienestar de todos los miembros de la sociedad, particularmente de los más débiles y necesitados utilizando los medios con los que dispone, y las propuestas de leyes contra accidentes expedidas el 30 de abril de 1904 en el Estado de México, en el México del porfiriato no se consideró brindar atención médica formal a los trabajadores, salvo algunas empresas ferrocarrileras, no se construyeron hospitales para atender a pacientes con enfermedades laborales...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29732106/access-to-benzo-fused-nine-membered-heterocyclic-alkenes-with-a-trifluoromethyl-carbinol-moiety-via-a-double-decarboxylative-formal-ring-expansion-process-under-palladium-catalysis
#9
Pulakesh Das, Satoshi Gondo, Punna Nagender, Hiroto Uno, Etsuko Tokunaga, Norio Shibata
Direct access to pharmaceutically attractive benzo-fused nine-membered heterocyclic alkenes 3 with a trifluoromethyl carbinol moiety was achieved via a palladium-catalyzed double-decarboxylative formal ring-expansion process from six-membered trifluoromethyl benzo[ d ][1,3]oxazinones 1 to nine-membered trifluoromethyl benzo[ c ][1,5]oxazonines 3 in the presence of vinylethylene carbonates 2 . Generation of a Pd-π-allyl zwitterionic intermediate was proposed in the catalytic cycle. The trifluoromethyl group in the benzoxazinanones 1 plays an important role throughout the transformation...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29730351/traumatically-brain-injured-donors-and-the-impact-on-lung-transplant-survival
#10
Todd C Crawford, Cecillia Lui, J Trent Magruder, Alejandro Suarez-Pierre, Jinny S Ha, Robert S Higgins, Stephen R Broderick, Christian A Merlo, Bo S Kim, Errol L Bush
BACKGROUND: Concern has been raised over inferior lung transplant survival associated with traumatic brain injury (TBI) organ donors. Our purpose was to explore the relationship between TBI donors and lung transplant survival in the lung allocation score (LAS) era. METHODS: We queried the UNOS Scientific Registry of Transplant Recipients and identified all adult (≥18 years) lung transplants performed from May 4, 2005 to December 31, 2015. Recipients were dichotomized based on donor cause of death, TBI versus non-TBI, propensity scored across eight variables (final LAS, pre-transplant ICU admission, pre-transplant ECMO, donor age ≥50 years, CMV antibody recipient-/donor+, ischemia time, annual center transplant volume, single versus double lung transplant), and matched 1:1 without replacement...
May 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29729085/palladium-catalyzed-mizoroki-heck-type-alkenylation-of-monoaryldialkylsulfoniums
#11
Daisuke Uno, Hiroko Minami, Shinya Otsuka, Keisuke Nogi, Hideki Yorimitsu
Mizoroki-Heck-type alkenylation of monoaryldialkylsulfoniums has been accomplished by means of palladium catalysts. Various combinations of monoarylsulfoniums and alkenes were adapted to the present reaction. Since monoaryldimethylsulfoniums can be readily prepared from the corresponding aryl methyl sulfides and methyl triflate, one-pot alkenylation of aryl methyl sulfide could be executed.
May 4, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29726965/pbrpredict-suite-a-suite-of-models-to-predict-peptide-recognition-domain-residues-from-protein-sequence
#12
Sumaiya Iqbal, Tamjidul Hoque
Motivation: Machine learning plays a substantial role in bioscience owing to the explosive growth in sequence data and the challenging application of computational methods. Peptide-recognition domains (PRDs) are critical as they promote coupled-binding with short peptide motifs of functional importance through transient interactions. It is challenging to build a reliable predictor of peptide-binding residue in proteins with diverse types of PRDs from protein sequence alone. On the other hand, it is vital to cope up with the sequencing speed and to broaden the scope of study...
May 2, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29725035/white-donor-younger-donor-and-double-lung-transplant-are-associated-with-better-survival-in-sarcoidosis-patients
#13
Oriana Salamo, Shiva Roghaee, Michael D Schweitzer, Alejandro Mantero, Shirin Shafazand, Michael Campos, Mehdi Mirsaeidi
Sarcoidosis commonly affects the lung. Lung transplantation (LT) is required when there is a severe and refractory involvement. We compared post-transplant survival rates of sarcoidosis patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). We also explored whether the race and age of the donor, and double lung transplant have any effect on the survival in the post transplant setting. We analyzed 9,727 adult patients with sarcoidosis, COPD, and IPF who underwent LT worldwide between 2005-2015 based on United Network for Organ Sharing (UNOS) database...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29723531/transplant-outcomes-for-congenital-heart-disease-patients-bridged-with-a-ventricular-assist-device
#14
Roosevelt Bryant, Raheel Rizwan, Chet R Villa, Farhan Zafar, Dennis Wells, Clifford Chin, Angela Lorts, David L Morales
BACKGROUND: Ventricular assist device (VAD) use as a bridge-to-transplant (BTT) for children with end-stage heart failure and congenital heart disease (CHD), although challenging, has increased but its impact on post-transplant outcome is unknown. This study describes post-transplant outcomes of CHD patients BTT with a VAD. METHODS: All heart transplants identified in UNOS database from 2006-2015 (N=21,865) were divided into four groups based on the diagnosis of CHD and VAD support at transplant: +CHD/+VAD, +CHD/-VAD, +VAD/-CHD and -VAD/-CHD...
April 30, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29723303/factors-associated-with-the-presentation-of-erosive-esophagitis-symptoms-in-health-checkup-subjects-a-prospective-multicenter-cohort-study
#15
Naomi Mochizuki, Tsuyoshi Fujita, Masao Kobayashi, Yukinao Yamazaki, Shuichi Terao, Tsuyoshi Sanuki, Akihiko Okada, Masayasu Adachi, Manabu Murakami, Yoshifumi Arisaka, Koji Uno, Atsuhiro Masuda, Masaru Yoshida, Eiji Umegaki, Hiromu Kutsumi, Takeshi Azuma
BACKGROUND: We aimed to clarify the factors associated with the presentation of erosive esophagitis (EE) symptoms in subjects undergoing health checkups. METHODS: We utilized baseline data from 7,552 subjects who underwent upper endoscopy for health screening in a prospective, multicenter cohort study. The subjects were asked to complete a questionnaire detailing their upper abdominal symptoms and lifestyle. Based on the heartburn and/or acid regurgitation frequency, the EE subjects were stratified into the following three groups: (1) at least one day a week (symptomatic EE [sEE]), (2) less than one day a week (mild symptomatic EE [msEE]), and (3) never (asymptomatic EE [aEE])...
2018: PloS One
https://www.readbyqxmd.com/read/29722081/liver-alone-or-simultaneous-liver-kidney-transplant-pre-transplant-chronic-kidney-disease-and-post-transplant-outcome-a-retrospective-study
#16
Shunji Nagai, Mohamed Safwan, Kelly Collins, Randolph E Schilke, Michael Rizzari, Dilip Moonka, Kimberly Brown, Anita Patel, Atsushi Yoshida, Marwan Abouljoud
The new Organ Procurement and Transplant Network/United Organ Sharing Network (OPTN/UNOS) simultaneous liver-kidney transplant (SLK) policy has been implemented. The aim of this study was to review liver transplant outcomes utilizing the new SLK policy. Liver transplant alone (LTA) and SLK patients between 2009 and 2015 were reviewed. Graft survival and post-transplant kidney function were investigated among LTA patients meeting the chronic kidney disease (CKD) criteria of the new policy (LTA-CKD group). In order to validate our findings, we reviewed and applied our analysis to the OPTN/UNOS registry...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29721176/pretreatment-monocyte-counts-and-neutrophil-counts-predict-the-risk-for-febrile-neutropenia-in-patients-undergoing-tpf-chemotherapy-for-head-and-neck-squamous-cell-carcinoma
#17
Marie Shimanuki, Yorihisa Imanishi, Yoichiro Sato, Nana Nakahara, Daisuke Totsuka, Emiri Sato, Sena Iguchi, Yasuo Sato, Keiko Soma, Yasutomo Araki, Seiji Shigetomi, Satoko Yoshida, Kosuke Uno, Yusuke Ogawa, Takehiro Tominaga, Yuichi Ikari, Junko Nagayama, Ayako Endo, Koshiro Miura, Takuya Tomioka, Hiroyuki Ozawa, Kaoru Ogawa
Background: Febrile neutropenia (FN) is the most serious hematologic toxicity of systemic chemotherapy. However, accurate prediction of FN development has been difficult because the risk varies largely depending on the chemotherapy regimen and various individual factors. Methods: We retrospectively analyzed diverse clinical factors including pretreatment hematological parameters to clarify the reliable predictors of FN development during chemotherapy with a docetaxel, cisplatin, and fluorouracil (TPF) regimen in patients with head and neck squamous cell carcinoma...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29720086/click-one-step-generation-of-conditional-knockout-mice
#18
Yoshiki Miyasaka, Yoshihiro Uno, Kazuto Yoshimi, Yayoi Kunihiro, Takuji Yoshimura, Tomohiro Tanaka, Harumi Ishikubo, Yuichi Hiraoka, Norihiko Takemoto, Takao Tanaka, Yoshihiro Ooguchi, Paul Skehel, Tomomi Aida, Junji Takeda, Tomoji Mashimo
BACKGROUND: CRISPR/Cas9 enables the targeting of genes in zygotes; however, efficient approaches to create loxP-flanked (floxed) alleles remain elusive. RESULTS: Here, we show that the electroporation of Cas9, two gRNAs, and long single-stranded DNA (lssDNA) into zygotes, termed CLICK (CRISPR with lssDNA inducing conditional knockout alleles), enables the quick generation of floxed alleles in mice and rats. CONCLUSIONS: The high efficiency of CLICK provides homozygous knock-ins in oocytes carrying tissue-specific Cre, which allows the one-step generation of conditional knockouts in founder (F0) mice...
May 2, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29719591/acidic-bile-salts-induces-mucosal-barrier-dysfunction-through-let-7a-reduction-during-gastric-carcinogenesis-after-helicobacter-pylori-eradication
#19
Yasushi Takahashi, Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Naoki Asano, Kiyotaka Asanuma, Tooru Shimosegawa
Gastric cancer (GC) after eradication for Helicobacter pylori ( H.pylori ) increases, but its carcinogenesis is not elucidated. It is mainly found in acid non-secretion areas (ANA), as mucosal regeneration in acid secretory areas (AA) after eradication changes the acidity and bile toxicity of gastric juice. We aimed to clarify the role of barrier dysfunction of ANA by the stimulation of pH3 bile acid cocktail (ABC) during carcinogenesis. We collected 18 patients after curative endoscopic resection for GC, identified later than 24 months after eradication, and took biopsies by Congo-red chromoendoscopy to distinguish AA and ANA (UMIN00018967)...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717275/selective-insulin-resistance-with-differential-expressions-of-irs-1-and-irs-2-in-human-nafld-livers
#20
Midori Honma, Shojiro Sawada, Yoshiyuki Ueno, Keigo Murakami, Tetsuya Yamada, Junhong Gao, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Sohei Tsukita, Kenji Uno, Junta Imai, Eiji Kakazu, Yasuteru Kondo, Kei Mizuno, Naoki Kawagishi, Tooru Shimosegawa, Hideki Katagiri
BACKGROUND/OBJECTIVE: Insulin signals, via the regulation of key enzyme expression, both suppress gluconeogenesis and enhance lipid synthesis in the liver. Animal studies have revealed insulin signaling favoring gluconeogenesis suppression to be selectively impaired in steatotic livers. However, whether, and if so how, such selective insulin resistance occurs in human steatotic livers remains unknown. Our aim was to investigate selective insulin resistance in human livers with non-alcoholic fatty liver disease (NAFLD)...
May 1, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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