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https://www.readbyqxmd.com/read/28935351/impact-of-left-ventricular-assist-device-related-complications-on-posttransplant-graft-survival
#1
Dhaval Chauhan, Alexis K Okoh, Setri Fugar, Rivandra Karanam, David Baran, Mark Zucker, Magarita Camacho, Mark J Russo
BACKGROUND: This study describes the impact of continuous-flow left-ventricular-assist device (CF-LVAD)-related complications on postoperative outcomes. METHODS: The United Network for Organ Sharing (UNOS) heart transplant follow-up data from 2005 to 2015 were obtained. CF-LVAD patients who were bridged to transplant were studied. Device-related complications (DRCs) at patient's last follow-up before transplantation were reported in 5 categories: device thrombosis (B1), infection (B2), device malfunction (B3), life-threatening arrhythmias (B4), and others (B5)...
September 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28934383/overexpression-of-micrornas-from-the-gtl2-rian-locus-contributes-to-postnatal-death-in-mice
#2
Soichiro Kumamoto, Nozomi Takahashi, Kayo Nomura, Makoto Fujiwara, Megumi Kijioka, Yoshinobu Uno, Yoichi Matsuda, Yusuke Sotomaru, Tomohiro Kono
The Dlk1-Dio3 imprinted domain functions in embryonic development but the roles of noncoding RNAs expressed from this domain remain unclear. We addressed this question by generating transgenic (TG) mice harbouring a BAC carrying IG-DMR (intergenic-differentially methylated region), Gtl2-DMR, Gtl2, Rtl1/Rtl1as, and part of Rian. High postnatal lethality (>85%) of the BAC-TG pups was observed in the maternally transmitted individuals (MAT-TG), but not following paternal transmission (PAT-TG). The DNA methylation status of IG-DMR and Gtl2-DMR in the BAC-allele was paternally imprinted similar to the genomic allele...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28934162/gas-chromatography-mass-spectrometry-for-metabolite-profiling-of-japanese-black-cattle-naturally-contaminated-with-zearalenone-and-sterigmatocystin
#3
Katsuki Toda, Emiko Kokushi, Seiichi Uno, Ayaka Shiiba, Hiroshi Hasunuma, Yasuo Fushimi, Missaka P B Wijayagunawardane, Chunhua Zhang, Osamu Yamato, Masayasu Taniguchi, Johanna Fink-Gremmels, Mitsuhiro Takagi
The objective of this study was to evaluate the metabolic profile of cattle fed with or without zearalenone (ZEN) and sterigmatocystin (STC)-contaminated diets using a gas chromatography-mass spectrometry metabolomics approach. Urinary samples were collected from individual animals (n = 6 per herd) from fattening female Japanese Black (JB) cattle herds (23 months old, 550-600 kg). Herd 1 had persistently high urinary ZEN and STC concentrations due to the presence of contaminated rice straw. Herd 2, the second female JB fattening herd (23 months old, 550-600 kg), received the same dietary feed as Herd 1, with non-contaminated rice straw...
September 21, 2017: Toxins
https://www.readbyqxmd.com/read/28931432/hypomethylated-domain-enriched-dna-motifs-prepattern-the-accessible-nucleosome-organization-in-teleosts
#4
Ryohei Nakamura, Ayako Uno, Masahiko Kumagai, Shinichi Morishita, Hiroyuki Takeda
BACKGROUND: Gene promoters in vertebrate genomes show distinct chromatin features such as stably positioned nucleosome array and DNA hypomethylation. The nucleosomes are known to have certain sequence preferences, and the prediction of nucleosome positioning from DNA sequence has been successful in some organisms such as yeast. However, at gene promoters where nucleosomes are much more stably positioned than in other regions, the sequence-based model has failed to work well, and sequence-independent mechanisms have been proposed...
September 20, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28926143/recurrence-of-iga-nephropathy-after-kidney-transplantation-in-steroid-continuation-versus-early-steroid-withdrawal-regimens-a-retrospective-analysis-of-the-unos-optn-database
#5
Napat Leeaphorn, Neetika Garg, Eliyahu V Khankin, Francesca Cardarelli, Martha Pavlakis
In the past 20 years, there has been an increase in use of steroid-withdrawal regimens in kidney transplantation. However, steroid withdrawal may be associated with an increased risk of recurrent IgA nephropathy (IgAN). Using UNOS/OPTN data, we analyzed adult patients with ESRD due to IgAN who received their first kidney transplant between 2000 and 2014. For the primary outcome, we used a competing risk analysis to compare the cumulative incidence of graft loss due to IgAN recurrence between early steroid-withdrawal (ESW) and steroid continuation groups...
September 19, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28922901/localization-of-an-aldo-keto-reductase-akr2e4-in-the-silkworm-bombyx-mori-lepidoptera-bombycidae
#6
K Yamamoto, Y Ozakiya, T Uno
The aldo-keto reductase AKR2E4 reduces 3-dehydroecdysone to ecdysone in the silkworm Bombyx mori L. In this study, a quantitative polymerase chain reaction analysis revealed that the level of AKR2E4 mRNA was higher in the testes than in other tissues, and a western immunoblot analysis revealed that the AKR2E4 content in the testes was stage-specific from the fifth larval instar to the pupal stage. Immunohistochemical analysis showed that the AKR2E4 protein was present in cyst cells associated with sperm cells and spermatocytes...
September 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28921680/measurement-of-urinary-concentrations-of-the-mycotoxins-zearalenone-and-sterigmatocystin-as-biomarkers-of-exposure-in%C3%A2-mares
#7
M Takagi, S Uno, E Kokushi, F Sato, Mmp Wijayagunawardane, J Fink-Gremmels
Mycotoxins may affect animal health, including reproduction. Little is known about the clinical relevance of exposure of horses to contaminated feed. This study aimed at (i) monitoring the levels of the mycotoxins zearalenone (ZEN), with its metabolites α- and β-zearalenol (α- and β-ZOL), and sterigmatocystin (STC) in urine samples from thoroughbred mares in Japan and (ii) relating these findings to the potential effects on reproductive efficacy of breeding mares. Sixty-three urine samples of breeding mares from 59 breeding farms were used...
September 18, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28917517/delayed-left-main-coronary-artery-obstruction-after-radiofrequency-induced-coronary-dissection-and-spasm-insights-from-optical-frequency-domain-imaging-and-intravascular-ultrasound-imaging
#8
Umihiko Kaneko, Yoshifumi Kashima, Daitaro Kannno, Takayuki Kitai, Hiroshi Taniguchi, Kikuya Uno, Tsutomu Fujita
No abstract text is available yet for this article.
September 6, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28914590/canine-salivary-glands-analysis-of-rab-and-snare-protein-expression-and-snare-complex-formation-with-diverse-tissue-properties
#9
Hiroshi Gomi, Hiromi Osawa, Rie Uno, Tadashi Yasui, Masahiro Hosaka, Seiji Torii, Azuma Tsukise
The comparative structure and expression of salivary components and vesicular transport proteins in the canine major salivary glands were investigated. Histochemical analysis revealed that the morphology of the five major salivary glands-parotid, submandibular, polystomatic sublingual, monostomatic sublingual, and zygomatic glands-was greatly diverse. Immunoblot analysis revealed that expression levels of α-amylase and antimicrobial proteins, such as lysozyme, lactoperoxidase, and lactoferrin, differed among the different glands...
September 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28913983/the-impact-of-ischemic-time-on-early-rejection-after-pediatric-heart-transplant
#10
H Sonali Magdo, Joshua M Friedland-Little, Sunkyung Yu, Robert J Gajarski, Kurt R Schumacher
Prolonged graft ischemia may be a risk factor for early rejection post-HTx, but this has not been well studied in children. Furthermore, factors moderating the association between IT and early rejection have not been investigated. From 2004 to 2012, pediatric HTx recipients (n = 2381) were identified from the UNOS database. A ROC curve determined the optimal IT discriminating patients by the presence of early rejection. Separate univariate analyses identified factors associated with: (i) early (prior to hospital discharge) rejection, and (ii) IT...
September 14, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28913731/inter-and-intra-observer-reproducibility-of-quantitative-analysis-for-fp-cit-spect-in-patients-with-dlb
#11
Atsutaka Okizaki, Michihiro Nakayama, Kaori Nakajima, Takayuki Katayama, Takahiro Uno, Fumiyoshi Morikawa, Juichiro Naoe, Koji Takahashi
BACKGROUND: Dopamine transporter single photon emission CT (DAT-SPECT) is useful in the evaluation of dementia with Lewy bodies (DLB). The specific binding ratio (SBR) is an index to measure DAT density. However, poorly reproducible cases are occasionally experienced in clinical practice. We hypothesized that distance-weighted histogram (DWH) may be useful to improve the reproducibility of SBR. The purpose of this study was to investigate inter- and intra-observer reproducibility of SBR with conventional and DWH methods, and to visually evaluate the precision in reference voxel of interest (VOI) definition using these methods...
September 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28905710/cleavage-speed-and-blastomere-number-in-dba-2j-compared-with-c57bl-6j-mouse-embryos
#12
Hirofumi Nishizono, Kyosuke Uno, Hiroyuki Abe
DBA/2J mice are among the oldest and most important inbred strains still used in many research fields. However, this strain has reproductive problems, which may consume considerable time and effort during experiments requiring a large population. Because the quality of DBA/2J embryos has not yet been described in detail, we compared DBA/2J mice with the reproductively efficient C57BL/6J strain. Compared with C57BL/6J embryos, DBA/2J embryos had a slower cleavage speed (mean ± 1 SD; first cleavage: C57BL/6J, 16...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28905174/mathematical-development-and-computational-analysis-of-harmonic-phase-magnetic-resonance-imaging-harp-mri-based-on-bloch-nuclear-magnetic-resonance-nmr-diffusion-model-for-myocardial-motion
#13
Michael O Dada, Babatunde Jayeoba, Bamidele O Awojoyogbe, Uno E Uno, Oluseyi E Awe
Harmonic Phase-Magnetic Resonance Imaging (HARP-MRI) is a tagged image analysis method that can measure myocardial motion and strain in near real-time and is considered a potential candidate to make magnetic resonance tagging clinically viable. However, analytical expressions of radially tagged transverse magnetization in polar coordinates (which is required to appropriately describe the shape of the heart) have not been explored because the physics required to directly connect myocardial deformation of tagged Nuclear Magnetic Resonance (NMR) transverse magnetization in polar geometry and the appropriate harmonic phase parameters are not yet available...
September 13, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28904389/high-wettability-of-liquid-caesium-iodine-with-solid-uranium-dioxide
#14
Ken Kurosaki, Masanori Suzuki, Masayoshi Uno, Hiroto Ishii, Masaya Kumagai, Keito Anada, Yukihiro Murakami, Yuji Ohishi, Hiroaki Muta, Toshihiro Tanaka, Shinsuke Yamanaka
In March 2011, the Fukushima Daiichi Nuclear Power Plant accident caused nuclear fuel to melt and the release of high-volatility fission products into the environment. Caesium and iodine caused environmental contamination and public exposure. Certain fission-product behaviours remain unclear. We found experimentally that liquid CsI disperses extremely favourably toward solid UO2, exhibiting a contact angle approaching zero. We further observed the presence of CsI several tens of micrometres below the surface of the solid UO2 sample, which would be caused by the infiltration of pores network by liquid CsI...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902104/a-replication-study-for-the-association-of-rs11190870-with-curve-severity-in-adolescent-idiopathic-scoliosis-in-japanese
#15
Yohei Takahashi, Ikuyo Kou, Yoji Ogura, Atsushi Miyake, Kazuki Takeda, Masahiro Nakajima, Shohei Minami, Noriaki Kawakami, Koki Uno, Manabu Ito, Ikuho Yonezawa, Takashi Kaito, Haruhisa Yanagida, Kei Watanabe, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Toshiaki Kotani, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Nobuyuki Fujita, Mitsuru Yagi, Kazuhiro Chiba, Katsuki Kono, Tsuyoshi Sakuma, Tsutomu Akazawa, Kotaro Nishida, Kenichiro Kakutani, Hideki Shigematsu, Takahiro Iida, Satoshi Demura, Naobumi Hosogane, Eijiro Okada, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa
STUDY DESIGN: Case-only study. OBJECTIVE: The aim of this study was to confirm the association of rs11190870 with AIS severity in Japanese patients with AIS. SUMMARY OF BACKGROUND DATA: Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies...
September 8, 2017: Spine
https://www.readbyqxmd.com/read/28901017/efficiency-of-two-sample-tests-via-the-restricted-mean-survival-time-for-analyzing-event-time-observations
#16
Lu Tian, Haoda Fu, Stephen J Ruberg, Hajime Uno, Lee-Jen Wei
In comparing two treatments with the event time observations, the hazard ratio (HR) estimate is routinely used to quantify the treatment difference. However, this model dependent estimate may be difficult to interpret clinically especially when the proportional hazards (PH) assumption is violated. An alternative estimation procedure for treatment efficacy based on the restricted means survival time or t-year mean survival time (t-MST) has been discussed extensively in the statistical and clinical literature...
September 12, 2017: Biometrics
https://www.readbyqxmd.com/read/28898542/maximizing-donor-allocation-a-review-of-unos-region-9-donor-heart-turn-downs
#17
Donna Mancini, Daniel Goldstein, Samantha Taylor, Leway Chen, Alan Gass, Samantha DeLair, Sean Pinney
This study was performed to determine if organ selection practices for heart utilization by Region 9 transplant programs were optimal, and to identify opportunities to increase local organ recovery. A retrospective review of de-identified region-wide donor data 1/1/10-12/31/13 was performed. Over the study period 537 heart donors were identified, of which 321 (60%) were transplanted. 216 consented hearts were not used; 190 of these were not recovered, and 26 were recovered but not transplanted. 245/321 (76%) hearts were transplanted at one of 5 regional programs, 15 (5%) were transplanted out of region as primary offers, and 61 (19%) were turned down in region and exported...
September 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28893357/fluoroquinolone-resistance-in-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-in-a-japanese-tertiary-hospital-silent-shifting-to-ctx-m-15-producing-k-pneumoniae
#18
Masashi Higashino, Mika Murata, Yoshitomo Morinaga, Norihiko Akamatsu, Junichi Matsuda, Kazuaki Takeda, Norihito Kaku, Kosuke Kosai, Naoki Uno, Hiroo Hasegawa, Katsunori Yanagihara
PURPOSE: Fluoroquinolone resistance (FQ-r) in extended-spectrum β-lactamase (ESBL) producers is an urgent health concern in countries where ESBL-producing K. pneumoniae (ESBL-Kpn) is prevalent. We investigated FQ-r in Japan where ESBL-Kpn is less prevalent. METHODOLOGY: Clinical ESBL-Kpn isolates from 2011 to 2013 were collected in Nagasaki University Hospital. The ESBL genotypes included CTX-M-15, and the mechanisms of FQ-r through plasmid-mediated quinolone resistance (PMQR) and mutations in quinolone resistance-determining regions (QRDRs) were examined...
September 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28893126/a-case-with-coil-embolization-for-ruptured-aneurysm-associated-with-fenestration-of-the-posterior-inferior-cerebellar-artery
#19
Kazushi Maeda, Ryota Motoie, Satoshi Karashima, Ryosuke Otsuji, Nice Ren, Shintaro Nagaoka, Yoshiaki Ikai, Junji Uno, Hidefuku Gi
An 87-year-old man hospitalized for subarachnoid hemorrhage showed a ruptured aneurysm arising from fenestration of the posterior inferior cerebellar artery. Endovascular treatment was selected and the aneurysm and superior limb were embolized completely using three coils. Fenestration of the posterior cerebellar artery is exceedingly rare. In addition, we present a first case of aneurysm as fenestration of the posterior inferior cerebellar artery that was definitively identified as a cause of bleeding.
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28892071/a-novel-rare-variant-r292h-in-rtn4r-affects-growth-cone-formation-and-possibly-contributes-to-schizophrenia-susceptibility
#20
H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y Uno, T Okada, M Ikeda, T Inada, A Branko, D Mori, T Yoshikawa, N Iwata, H Nakamura, T Yamashita, N Ozaki
Reticulon 4 receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hotspot for schizophrenia (SCZ) and autism spectrum disorder (ASD). Recently, rare variants such as copy-number variants and single-nucleotide variants have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants...
August 22, 2017: Translational Psychiatry
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