Alexandra Schäfer, Andrea Marzi, Wakako Furuyama, Nicholas J Catanzaro, Cameron Nguyen, Elaine Haddock, Friederike Feldmann, Kimberly Meade-White, Tina Thomas, Miranda L Hubbard, Kendra L Gully, Sarah R Leist, Pablo Hock, Timothy A Bell, Gabriela E De la Cruz, Bentley R Midkiff, David R Martinez, Ginger D Shaw, Darla R Miller, Michael J Vernon, Rachel L Graham, Dale O Cowley, Stephanie A Montgomery, Klaus Schughart, Fernando Pardo Manuel de Villena, Gregory K Wilkerson, Martin T Ferris, Heinz Feldmann, Ralph S Baric
Ebola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans. Host genetic variation plays a critical role, yet the identity of host susceptibility loci in mammals remains unknown. Using genetic reference populations, we generate an F2 mapping cohort to identify host susceptibility loci that regulate EVD. While disease-resistant mice display minimal pathogenesis, susceptible mice display severe liver pathology consistent with EVD-like disease and transcriptional signatures associated with inflammatory and liver metabolic processes...
April 21, 2024: Cell Reports