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https://www.readbyqxmd.com/read/27735988/detection-of-flt3-tkd-and-idh1-mutations-in-pakistani-acute-myeloid-leukemia-patients-by-denaturing-hplc
#1
Akbar Ali, Rosemary E Gale, Abdul Rauf Shakoori
Acute myeloid leukemia (AML) is characterized by an increase in the number of myeloid cells in the marrow and an arrest in their maturation. Various genetic mutations are associated with AML. FMS-like tyrosine kinase 3 (FLT3), a member of the class III receptor tyrosine kinase family, plays an important role in stem cell survival, and the development of dendritic and natural killer cells. FLT3/TKD mutations are generally missense mutations or in-frame alterations of residues D835 and I836 within the activation loop of the FLT3 protein...
October 13, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27725920/flow-cytometric-analysis-four-year-experience-in-a-tertiary-care-centre-of-pakistan
#2
Imran N Ahmad, Salman Assad, Muhammad Rahman, Haider Ghazanfar
PURPOSE:   This study summarizes a four-year experience from the analysis of hematolymphoid malignancies in Pakistani population using a database of six-colored flow cytometry. METHODS: A cross-sectional survey of 323 specimens of hematolymphoid malignancies using six-colored flow cytometry (FC) was carried out in Shifa International Hospital, Islamabad, Pakistan from June 2012 to June 2016. The criterion for specimen adequacy was that the cases have abnormal populations by FC, and the specimen age (time from biopsy to being examined by the six-color FC tube) of three days or less was to be included in the study...
September 1, 2016: Curēus
https://www.readbyqxmd.com/read/27467375/the-impact-of-socioeconomic-factors-on-the-outcome-of-childhood-acute-lymphoblastic-leukemia-all-treatment-in-a-low-middle-income-country-lmic
#3
Kishwer Jabeen, Mohammed S Ashraf, Sundus Iftikhar, Asim F Belgaumi
Survival for childhood acute lymphoblastic leukemia (ALL) has improved significantly, but these benefits may not be available to many children from low and middle income countries, where reasons for treatment failure may be unique to their environment. We retrospectively reviewed data on pediatric (1 to 18 y or younger) patients with newly diagnosed ALL treated over 5 years at a children's cancer hospital in Pakistan. Patients were treated with modified Berlin-Frankfurt-Muenster -based therapy without risk stratification...
November 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27464847/toxic-metal-pollution-in-pakistan-and-its-possible-risks-to-public-health
#4
Shakirullah Khan Shakir, Azizullah Azizullah, Waheed Murad, Muhammad K Daud, Farhat Nabeela, Hazir Rahman, Shafiq Ur Rehman, Donat-Peter Häder
Environmental pollution has increased many folds in recent years and in some places has reached levels that are toxic to living things. Among pollutant types, toxic heavy metals and metalloids are among the chemicals that pose the highest threat to biological systems (Jjemba 2004). Unlike organic pollutants, which are biodegradable, heavy metals are not degraded into less hazardous end products (Gupta et al. 2001). Low concentrations of some heavy metals are essential for life, but some of them like Hg, As, Pb and Cd are biologically non-essential and very toxic to living organisms...
July 28, 2016: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27225156/assessment-of-wt1-expression-as-a-marker-of-treatment-outcome-in-karyotype-normal-acute-myeloid-leukemia-patients-in-pakistan
#5
Zeeshan Ansar Ahmed, Muhammad Shariq Shaikh, Tariq Moatter
Currently, there is an effort to predict relapse by follow-up monitoring of MRD and subsequently to begin the treatment of the patients during their clinical and hematological remission prior to overt hematological relapse. Expression of WT1 in AML is known to be independently associated with significant inferior response to therapy and short survival outcome. Follow-up monitoring of WT1 gene expression during or after therapy would be a valuable predictive marker for early recurrence or relapse of AML disease...
May 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27221935/acute-lymphoblastic-leukemia-in-adults-an-analysis-of-51-cases-from-a-tertiary-care-center-in-pakistan
#6
Sadia Sultan, Syed Mohammed Irfan, Saira Parveen1, Sanober Mustafa2
BACKGROUND: Acute lymphoblastic leukemia (ALL) is a malignant disease in which early lymphoid precursors proliferate and replace the normal hematopoiesis. It has distinctive clinical and biological features. In respect to adult ALL, available data from Pakistan are limited. Therefore we reviewed the demographical and clinico- hematological profiles along with FAB stratification of adult patients with ALL presented at our hospital. MATERIALS AND METHODS: In this cross sectional study, 51 adults (≥15 years) patients with ALL were enrolled from January 2010 to December 2014...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27011480/tracheotomy-in-cancer-patients-experience-from-a-cancer-hospital-in-pakistan
#7
Abu Bakar Hafeez Bhatti, Hassan Iqbal, Raza Hussain, Aamir Ali Syed, Arif Jamshed
Tracheotomy is commonly performed for the management of upper airway compromise. Trauma and head and neck cancers are the most frequent indications. The objective of this study was to share our experience with tracheotomy performed for a broad range of malignancies including but not limited to head and neck cancer. This study is a retrospective case series of patients who underwent tracheotomy from January 2004 to June 2012 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. A total of 130 patients were included in the study...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26625817/acute-promyelocytic-leukemia-a-single-center-study-from-southern-pakistan
#8
Sadia Sultan, Syed Mohammed Irfan, Sana Ashar
BACKGROUND: Acute promyelocytic leukemia (APL) is a distinctive clinical, biological and molecular subtype of acute myeloid leukemia. However, data from Pakistan are scarce. Therefore we reviewed the demographic and clinical profile along with risk stratification of APL patients at our center. MATERIALS AND METHODS: In this descriptive cross sectional study, 26 patients with acute promyelocytic leukemia were enrolled from January 2011 to June 2015. Data were analyzed with SPSS version 22...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26625756/low-frequency-of-etv6-runx1-t-12-21-in-saudi-arabian-pediatric-acute-lymphoblastic-leukemia-patients-association-with-clinical-parameters-and-early-remission
#9
Khaled Aljamaan, Talal Khalid Aljumah, Saleh Aloraibi, Muhammad Absar, Zafar Iqbal
BACKGROUND: Pediatric acute lymphoblastic leukemia (pALL) patients at King Abdulaziz Medical City represent a pure Saudi Arabian population. ETV6-RUNX1 positive pALL patients have good prognosis as compared to ETV6-RUNX1 negative counterparts. Therefore, frequencies of these two patient groups have a huge consideration in treatment strategies of pALL in a given population. Different geographical locations have been reported to have different frequencies of ETV6-RUNX1 ranging from 10% in Southeast Asia to 30% in Australia...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26266519/high-frequency-and-poor-prognosis-of-late-childhood-bcr-abl-positive-and-mll-af4-positive-all-define-the-need-for-advanced-molecular-diagnostics-and-improved-therapeutic-strategies-in-pediatric-b-all-in-pakistan
#10
Zafar Iqbal, Tanveer Akhtar, Tashfin Awan, Aamer Aleem, Noreen Sabir, Mahmood Rasool, Muhammad Absar, Afia M Akram, Masood A Shammas, Ijaz H Shah, Muhammad Khalid, Abid S Taj, Abid Jameel, Abdullah Alanazi, Ammara T Gill, Jamil Amjad Hashmi, Akhtar Hussain, Muhammad Farooq Sabar, Ahmad M Khalid, Mehmood Hussain Qazi, Sajjad Karim, Muhammad Hassan Siddiqi, Aamir Mahmood, Mudassar Iqbal, Anjum Saeed, Muhammad Imran Irfan
BACKGROUND: Fusion oncogenes (FOs) resulting from chromosomal abnormalities have an important role in leukemogenesis in pediatric B cell acute lymphoblastic leukemia (ALL). The most common FOs are BCR-ABL, MLL-AF4, ETV6-RUNX1, and TCF3-PBX1, all of which have important prognostic and drug selection implications. Moreover, frequencies of FOs have ethnic variations. We studied Pakistani frequencies of FOs, clinical pattern, and outcome in pediatric B-ALL. METHODS: FOs were studied in 188 patients at diagnosis using reverse transcriptase-polymerase chain reaction (RT-PCR) and interphase fluorescent in situ hybridization (FISH)...
October 2015: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/26225669/trends-and-analysis-of-cancer-incidence-for-common-male-and-female-cancers-in-the-population-of-punjab-province-of-pakistan-during-1984-to-2014
#11
Khalid Masood, Andleeb Masood, Junaid Zafar, Abubaker Shahid, Mujahid Kamran, Sohail Murad, Misbah Masood, Zafar Alluddin, Masooma Riaz, Naseem Akhter, Munir Ahmad, Fayyaz Ahmad, Javaid Akhtar, Muhammad Naeem
BACKGROUND: The Pakistan Atomic Energy Commission Cancer Registry (PAECCR) program has made availability of a common cancer incidence database possible in Pakistan. The cancer incidence data from nuclear medicine and oncology institutes were gathered and presented. MATERIALS AND METHODS: The cancer incidence data for the last 30 years (1984-2014) are included to describe a data set of male and female patients. The data analysis concerning occurrence, trends of common cancers in male and female patients, stage-wise distribution, and mortality/follow-up cases is also incorporated for the last 10 years (2004-2014)...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25987039/detection-of-bcr-abl-fusion-gene-by-hematological-and-cytogenetical-analysis-in-chronic-myeloid-leukemia-patients-in-quetta-pakistan
#12
Bibi Tahira, Muhammad Asif, Samiullah Khan, Abrar Hussain, Muhammad Naeem Shahwani, Arif Malik, Syed Inayatullah, Zafar Iqbal, Mahmood Rasool
BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells, caused by reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), known as the Philadelphia chromosome. MATERIALS AND METHODS: A total of 51 CML patients were recruited in this study. Complete blood counts of all CML patients were performed to find out their total leukocytes, hemoglobin and platelets. FISH was performed for the detection of BCR-ABL fusion and cryptogenic tests using bone marrow samples were performed for the conformation of Ph (9;22)(q34;q11) and variant translocation mechanisms...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25982135/clinical-features-and-induction-outcome-of-childhood-acute-lymphoblastic-leukemia-in-a-lower-middle-income-population-a-multi-institutional-report-from-pakistan
#13
MULTICENTER STUDY
Zehra Fadoo, Imran Nisar, Fatimah Yousuf, Laila Saleem Lakhani, Shamvil Ashraf, Uzma Imam, Junaid Zaheer, Ahmed Naqvi, Asim Belgaumi
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood. Some evidence suggests differences in clinical and cytogenetic characteristics of ALL based on geographic and ethnic variations. However, data on ALL characteristics and early outcome of therapy from low/middle-income countries such as Pakistan are scanty. PROCEDURE: A prospective, multi-institutional cohort study in Karachi enrolled 646 newly diagnosed children with ALL over 3 years...
October 2015: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/25743836/zap-70-protein-expression-in-b-cell-chronic-lymphoid-leukemia-a-single-center-experience-from-pakistan
#14
Rozina Zeeshan, Syed Mohammed Irfan, Sadia Sultan, Sanjana Bhimani
BACKGROUND: Chronic lymphoid leukemia (CLL) is the most frequent type of adult leukemia. The Rai and Binet staging systems have been well recognized as standards for assessing the treatment requirements and overall survival in CLL patients. However, there is a need to seek newer prognostic markers to identify stable or progressive forms of CLL that will facilitate risk-adapted treatment strategies. Currently a molecular biomarker ZAP-70 has attracted interest as providing prognostic information in CLL patients...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25684527/clinico-hematological-profile-of-patients-with-b-chronic-lymphoid-leukemia-in-pakistan
#15
Rozina Zeeshan, Sadia Sultan, Syed Muhammad Irfan, Jamaludin Kakar, Muhammad Asif Hameed
BACKGROUND: Chronic lymphoid leukemia (CLL) is not an uncommon hematological malignancy which primarily affects elderly individuals. It is more common in developed world than in developing countries. The rational of this study was to determine the clinico-hematological profile in Pakistan. MATERIALS AND METHODS: In this prospective cross sectional study, sixty patients with CLL were enrolled from January 2011 to June 2013. Data were analyzed with SPSS version 21...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25153014/a-statistical-evaluation-of-common-cancer-trends-and-cancer-occurrence-by-age-group-in-the-population-of-lahore-pakistan-1984-2011
#16
K Masood, T Zafar, J Zafar
BACKGROUND: Due to the unavailability of a common cancer incidence database in Pakistan, the cancer incidence data from nuclear medicine and oncology institutes have been gathered and presented. METHODS: The cancer incidence data for the last 27 years (1984-2011) is included to present a data set of male and female patients. The data analysis concerning occurrence, trends of common cancers in male and female patients, stage-wise distribution, and mortality/follow-up cases is also incorporated for the last 7 years (2004-2011)...
2014: Journal of Registry Management
https://www.readbyqxmd.com/read/25097530/heterogeneity-of-bcr-abl-rearrangement-in-patients-with-chronic-myeloid-leukemia-in-pakistan
#17
Najia Tabassum, Mohammad Saboor, Rubina Ghani, Moinuddin Moinuddin
BACKGROUND AND OBJECTIVE: Breakpoint cluster region-Abelson (BCR-ABL) rearrangement or Philadelphia (Ph) chromosome in Chronic Myeloid Leukemia (CML) is derived from a reciprocal chromosomal translocation between ABL gene on chromosome 9 and BCR gene on chromosome 22. This chimeric protein has various sizes and therefore different clinical behaviour. The purpose of this study was to determine the heterogeneity of BCR-ABL rearrangement in patients with Ph(+)CML in Pakistan. METHODS: The study was conducted at Civil Hospital and Baqai Institute of Hematology (BIH) Karachi...
July 2014: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/24870754/molecular-genetic-studies-on-167-pediatric-all-patients-from-different-areas-of-pakistan-confirm-a-low-frequency-of-the-favorable-prognosis-fusion-oncogene-tel-aml1-t-12-21-in-underdeveloped-countries-of-the-region
#18
Zafar Iqbal
TEL-AML1 fusion oncogene (t 12; 21) is the most common chromosomal abnormality in childhood acute lymphoblastic leukemia (ALL). This translocation is associated with a good prognosis and rarely shows chemotherapeutic resistance to 3-drug based remission induction phase of treatment as well as overall treatment. Thus, the higher the frequency of this fusion oncogene, the easier to manage childhood ALL in a given region with less intensive chemotherapy. Although global frequency of TEL-AML1 has been reported to be 20-30%, a very low frequency has been found in some geographical regions, including one study from Lahore, Punjab, Pakistan and others from India...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/24864629/malignant-mediastinal-mass-in-children-a-single-institutional-experience-from-a-developing-country
#19
Naureen Mushtaq, Muhammad Matloob Alam, Scherherzade Aslam, Zehra Fadoo, Anwar-ul-Haq
OBJECTIVE: To determine the clinical spectrum and management outcomes of paediatric patients with modiastinal mass in a Karachi hospital. METHODS: Medical records of all cases of mediastinal masses in children diagnosed and treated between January 2005 and December 2011 were retrospectively reviewed to evaluate the mode of presentation, histopathological diagnosis, radiologic findings and management outcomes at Aga Khan University Hospital, Karachi, Pakistan. SPSS 19 was used for data analysis...
April 2014: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/24639858/frequency-of-jak2-v617f-mutation-in-patients-with-philadelphia-positive-chronic-myeloid-leukemia-in-pakistan
#20
Najia Tabassum, Mohammed Saboor, Rubina Ghani, Moinuddin Moinuddin
BACKGROUND AND OBJECTIVE: Co-existence of myeloproliferative disorders (MPD) and Janus associated kinase 2 mutation (JAK2 V617F) is a well-established fact. Only few case reports are available showing presence of JAK2 V617F mutation in chronic myeloid leukemia (CML). Purpose of this study was to determine the frequency of JAK2 V617F mutation in Philadelphia Chromosome positive (Ph (+)) CML patients in Pakistan. METHODS: The study was conducted from August 2009 to July 2010 at Civil Hospital and Baqai Institute of Hematology (BIH) Karachi...
January 2014: Pakistan Journal of Medical Sciences Quarterly
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