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https://www.readbyqxmd.com/read/29452400/sleep-quality-in-well-defined-lyme-disease-a-clinical-cohort-study-in-maryland
#1
Eric R Weinstein, Alison W Rebman, John N Aucott, Doug Johnson-Greene, Kathleen T Bechtold
Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Methods: This paper draws from a clinical cohort study of early LD participants (n=122) and a sub-cohort of individuals who later met criteria for PTLDS (n=6)...
February 14, 2018: Sleep
https://www.readbyqxmd.com/read/29452296/development-and-persistence-of-suspected-neuropathic-pain-after-total-knee-arthroplasty-in-individuals-with-osteoarthritis
#2
Matthew Fitzsimmons, Eloise Carr, Linda Woodhouse, Geoff P Bostick
BACKGROUND: Despite the effectiveness of total knee arthroplasty (TKA) for osteoarthritis (OA), up to 20% will report knee pain 1-year after surgery. One possible reason is the development of neuropathic pain before or after TKA. OBJECTIVE: To longitudinally describe suspected neuropathic pain in patients pre- and post-TKA and to explore relationships between pre-TKA suspected neuropathic pain and post-TKA outcomes. DESIGN: Prospective observational study...
February 13, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29452219/increased-cd4-counts-pain-and-depression-are-correlates-of-lower-sleep-quality-in-treated-hiv-positive-patients-with-low-baseline-cd4-counts
#3
K N Redman, A S Karstaedt, K Scheuermaier
Poor sleep quality leads to increased immune activation and immune activation leads to worse sleep quality. South African HIV positive patients typically have delayed start of treatment, which has been associated with CD4+ effector T cells being more spontaneously activated in chronically treated patients. This cross-sectional study investigated whether subjective sleep quality was associated with CD4+ T lymphocyte reconstitution in treated South African HIV+ patients. One hundred and thirty-nine treated HIV+ patients (109 F, age average (SD)= 43 (9)) were recruited from Chris Hani Baragwanath Academic Hospital in Soweto, Johannesburg, South Africa...
February 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29452000/optimal-items-for-assessing-sluggish-cognitive-tempo-in-children-across-mother-father-and-teacher-ratings
#4
Belén Sáez, Mateu Servera, Stephen P Becker, G Leonard Burns
A recent meta-analysis identified optimal items for assessing sluggish cognitive tempo (SCT) as distinct from attention deficit/hyperactivity disorder inattention (ADHD-IN), and a preliminary study with teacher ratings of children in the United States found strong support for the convergent and discriminant validity of 15 SCT items. The current study evaluated whether the same 15 SCT items demonstrated convergent and discriminant validity from ADHD-IN in a large, community-based sample of children in Spain, and whether validity results were replicated across mother, father, and teacher ratings...
February 16, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29451933/depressive-symptoms-and-physical-frailty-in-older-adults-with-chronic-heart-failure-a-cross-sectional-study
#5
Youn-Jung Son, Eun Ji Seo
Depressive symptoms and physical frailty have been reported to be predictive of adverse outcomes in individuals with heart failure (HF). Depressive symptoms could be a predisposing factor of physical frailty in older adults. Despite the high prevalence of HF, few studies on the relationship between these two factors have been performed in older adults with HF. To identify the relationship between depressive symptoms and physical frailty in HF, 190 older adults with HF were recruited from an outpatient clinic at a tertiary hospital in South Korea...
February 13, 2018: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#6
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451819/protection-from-chronic-stress-and-depressive-symptom-induced-vascular-endothelial-dysfunction-in-female-rats-is-abolished-by-pre-existing-metabolic-disease
#7
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
While it is known that chronic stress and clinical depression are powerful predictors of poor cardiovascular outcomes, recent clinical evidence has identified correlations between the development of metabolic disease and that for depressive symptoms; creating a combined condition of severely elevated cardiovascular disease risk. In this companion manuscript, we determine the impact of pre-existing metabolic disease on the relationship between chronic stress//depressive symptoms and vascular function, using the obese Zucker (OZR) and the unpredictable chronic mild stress UCMS models...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451662/what-clinical-functional-and-psychological-factors-before-treatment-are-predictors-of-poor-quality-of-life-in-cancer-patients-at-the-end-of-chemotherapy
#8
Ariella Sebastião Mangia, Nara Lisiane de Oliveira Coqueiro, Fernanda Cabral Azevedo, Hiago Tomaz da Silva Araujo, Elizandra de Oliveira Amorim, Cibelli Navarro Rodrigues Alves, Calvino Camargo, Allex Jardim da Fonseca
OBJECTIVE: To correlate physical activity level (PAL), functional capacity and psychological state with quality of life (QoL) in cancer patients undergoing chemotherapy (CT). METHOD: Observational cohort study. Patients (n=121) with any primary cancer site with indications of chemotherapy with palliative or curative intent were evaluated at three moments: 1) patient admission (week 0), before chemotherapy; 2) week 8; 3) end of CT. Data were collected regarding QoL, PAL, clinical data, functional capacity (short walking distance test, sitting-rising test, isometric manual gripping force), and anxiety and depression tests...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451303/sex-specific-manifestation-of-genetic-risk-for-attention-deficit-hyperactivity-disorder-in-the-general-population
#9
Joanna Martin, Mark J Taylor, Mina Rydell, Lucy Riglin, Olga Eyre, Yi Lu, Sebastian Lundström, Henrik Larsson, Anita Thapar, Paul Lichtenstein
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that females might be protected from developing ADHD, requiring a higher burden of genetic risk to manifest the disorder. METHODS: We tested these two hypotheses, using common variant genetic data from two population-based cohorts...
February 16, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29451300/decreased-anterior-cingulate-activation-in-a-motor-task-in-youths-with-bipolar-disorder
#10
Jace B King, Jeffrey S Anderson, Deborah A Yurgelun-Todd, Punitha Subramaniam, Marie R Ehrler, Melissa P Lopez-Larson
BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging...
February 16, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29451287/computational-identification-of-the-binding-mechanism-of-a-triple-reuptake-inhibitor-amitifadine-for-the-treatment-of-major-depressive-disorder
#11
Weiwei Xue, Panpan Wang, Gao Tu, Fengyuan Yang, Guoxun Zheng, Xiaofeng Li, Xiaoxu Li, Yuzong Chen, Xiaojun Yao, Feng Zhu
Amitifadine, the only drug ever clinically tested in Phase 3 for treating depression, is a triple reuptake inhibitor (TRI) that simultaneously interacts with human monoamine transporters (MATs) including hSERT, hNET and hDAT. This novel multi-target strategy improves drug efficacy and reduces the toxic side effects of drugs. However, the binding modes accounting for amitifadine's polypharmacological mode of action are still elusive, and extensive exploration of the amitifadine-target interactions between amitifadine and MATs is urgently needed...
February 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29451073/mental-health-problems-among-whistleblowers-a-comparative-study
#12
Peter G van der Velden, Mauro Pecoraro, Mijke S Houwerzijl, Erik van der Meulen
Whistleblowers play a very important and indispensable role in society and health care sector, but their act may elicit retaliation and other negative effects, which may impact their mental health. The main aim of the present comparative study is to assess to what extent whistleblowers ( N = 27) more often suffer from severe mental health problems than other population-based groups in the Netherlands, i.e., matched controls ( N = 135), cancer patients ( N = 130), persons with (partial) work disabilities ( N = 194), physically "healthy" persons ( N = 200), and general population ( N = 1026), using the 36-Item Short-Form Health Survey scales (for general mental health) and the Symptom Checklist-90-Revised scales (for specific mental health problems: depression, anxiety, agoraphobia, interpersonal sensitivity and distrust, and sleeping problems)...
January 1, 2018: Psychological Reports
https://www.readbyqxmd.com/read/29450921/sexual-minority-adults-a-national-survey-on-depression-religious-fundamentalism-parent-relationship-quality-acceptance
#13
Katie Heiden-Rootes, Ashley Wiegand, Danielle Bono
Sexual minority persons from religious families may experience low acceptance by parents, however, little is known about the relationship of religiosity and parent relationships on mental health into adulthood. This study sought to test a moderated mediation model predicting depression based on religious fundamentalism, parent acceptance, and parent-child relationship quality. Sexual minority adult participants (n = 384) from across the U.S. completed a web-based, anonymous survey. Results found a conditional indirect effect of religious fundamentalism on depression through parent acceptance with the parent-child relationship quality moderating the relationship between parent acceptance and depression...
February 15, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29450863/using-self-reported-patient-experiences-to-understand-patient-burden-learnings-from-digital-patient-communities-in-ankylosing-spondylitis
#14
Prashanth Sunkureddi, Dawn Gibson, Stephen Doogan, John Heid, Samir Benosman, Yujin Park
INTRODUCTION: Online communities contain a wealth of information containing unsolicited patient experiences that may go beyond what is captured by guided surveys or patient-reported outcome (PRO) instruments used in clinical settings. This study described patient experiences reported online to better understand the day-to-day disease burden of ankylosing spondylitis (AS). METHODS: Unguided, English-language patient narratives reported between January 2010 and May 2016 were collected from 52 online sources (e...
February 15, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29450796/prospective-comparison-of-the-minnesota-multiphasic-personality-inventory-2-mmpi-2-and-mmpi-2-restructured-form-mmpi-2-rf-in-predicting-treatment-outcomes-among-patients-with-chronic-low-back-pain
#15
Anthony M Tarescavage, Judith Scheman, Yossef S Ben-Porath
The purpose of the current study was to examine the relative utility of the most updated MMPI adult instrument, the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), which was designed to address psychometric limitations of the MMPI-2. To this end, we compared mean scores and correlates of emotional distress treatment outcomes using the Depression Anxiety Stress Scales in a sample of 230 patients (73 males, 157 females) who had completed an interdisciplinary chronic pain rehabilitation program...
February 15, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29449945/psychosocial-factors-associated-with-change-in-pain-and-disability-outcomes-in-chronic-low-back-pain-patients-treated-by-physiotherapist-a-systematic-review
#16
Ahmed Alhowimel, Mazyad AlOtaibi, Kathryn Radford, Neil Coulson
Background: Almost 80% of people have low back pain at least once in their life. Clinical guidelines emphasize the use of conservative physiotherapy and the importance of staying active. While the psychological factors predicting poor recovery following surgical intervention are understood, the psychosocial factors associated with poor outcomes following physiotherapy have yet to be identified. Methods: Electronic searches of PubMed, Medline, CINAHL, PsycINFO and EBSCO were conducted using terms relating to psychosocial factors, chronic low back pain, disability and physiotherapy...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29449944/dexmedetomidine-use-during-epiduroscopy-reduces-fentanyl-use-and-postoperative-nausea-and-vomiting-a-single-center-retrospective-study
#17
Takashi Suzuki, Ryota Inokuchi, Kazuo Hanaoka, Machi Suka, Hiroyuki Yanagisawa
Objectives: Minimally invasive epiduroscopy has recently been reported as an effective treatment procedure for chronic and intractable low back pain. However, no study has determined safe anesthetics for monitored anesthesia care during epiduroscopy. We aimed to compare and evaluate conventional monitored anesthesia care drugs with dexmedetomidine. Methods: A retrospective study including all patients who underwent epiduroscopy at the JR Tokyo General Hospital from April 2011 to March 2016 was designed...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29449828/understanding-spreading-depression-from-headache-to-sudden-unexpected-death
#18
REVIEW
Olga Cozzolino, Maria Marchese, Francesco Trovato, Enrico Pracucci, Gian Michele Ratto, Maria Gabriella Buzzi, Federico Sicca, Filippo M Santorelli
Spreading depression (SD) is a neurophysiological phenomenon characterized by abrupt changes in intracellular ion gradients and sustained depolarization of neurons. It leads to loss of electrical activity, changes in the synaptic architecture, and an altered vascular response. Although SD is often described as a unique phenomenon with homogeneous characteristics, it may be strongly affected by the particular triggering event and by genetic background. Furthermore, SD may contribute differently to the pathogenesis of widely heterogeneous clinical conditions...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29449202/a-web-based-psychoeducational-intervention-for-adolescent-depression-design-and-development-of-moodhwb
#19
Rhys Bevan Jones, Anita Thapar, Frances Rice, Harriet Beeching, Rachel Cichosz, Becky Mars, Daniel J Smith, Sally Merry, Paul Stallard, Ian Jones, Ajay K Thapar, Sharon A Simpson
BACKGROUND: Depression is common in adolescence and leads to distress and impairment in individuals, families and carers. Treatment and prevention guidelines highlight the key role of information and evidence-based psychosocial interventions not only for individuals but also for their families and carers. Engaging young people in prevention and early intervention programs is a challenge, and early treatment and prevention of adolescent depression is a major public health concern. There has been growing interest in psychoeducational interventions to provide accurate information about health issues and to enhance and develop self-management skills...
February 15, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29449183/altered-resting-state-voxel-level-whole-brain-functional-connectivity-in-depressed-parkinson-s-disease
#20
Hansheng Wang, Huiyue Chen, Jiahui Wu, Li Tao, Ya Pang, Min Gu, Fajin Lv, Tianyou Luo, Oumei Cheng, Ke Sheng, Jin Luo, Yida Hu, Weidong Fang
BACKGROUND: Depression is one of the most common non-motor symptoms in Parkinson's disease (PD), but its pathogenesis is still not very clear. Recently, degree centrality, a voxel-level whole-brain functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging, has provided the most promising way to explore the neural network mechanisms underlying depressed PD. METHODS: Degree centrality, voxel-wise image and clinical symptoms correlation and secondary seed-based FC analyses were performed in twenty-seven drug-naïve, early stage depressed PD patients, 27 non-depressed PD patients and 27 healthy controls (HCs) to reveal voxel-level whole-brain FC changes in depressed PD...
February 9, 2018: Parkinsonism & related Disorders
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