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https://www.readbyqxmd.com/read/27933697/total-magnetic-resonance-imaging-burden-of-cerebral-small-vessel-disease-is-associated-with-post-stroke-depression-in-patients-with-acute-lacunar-stroke
#1
X Zhang, Y Tang, Y Xie, C Ding, J Xiao, X Jiang, H Shan, Y Lin, C Li, D Hu, T Li, L Sheng
BACKGROUND AND PURPOSE: Despite extensive studies on post-stroke depression (PSD), the role of the total burden of cerebral small-vessel disease (cSVD) in its pathogenesis remains unclear. METHODS: We conducted a magnetic resonance imaging (MRI)-based cohort study to investigate the relationship between total MRI burden of cSVD and PSD among patients with first-ever lacunar stroke. From June 2013 to January 2016, 374 patients were consecutively recruited. PSD was identified using the Chinese version of the Structured Clinical Interview for DSM-IV...
December 9, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27933461/factors-associated-with-hiv-testing-among-participants-from-substance-use-disorder-treatment-programs-in-the-us-a-machine-learning-approach
#2
Yue Pan, Hongmei Liu, Lisa R Metsch, Daniel J Feaster
HIV testing is the foundation for consolidated HIV treatment and prevention. In this study, we aim to discover the most relevant variables for predicting HIV testing uptake among substance users in substance use disorder treatment programs by applying random forest (RF), a robust multivariate statistical learning method. We also provide a descriptive introduction to this method for those who are unfamiliar with it. We used data from the National Institute on Drug Abuse Clinical Trials Network HIV testing and counseling study (CTN-0032)...
December 8, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27933365/ketamine-decreases-sensitivity-of-male-rats-to-misleading-negative-feedback-in-a-probabilistic-reversal-learning-task
#3
Michal Rychlik, Eva Bollen, Rafal Rygula
RATIONALE: Depression is characterized by an excessive attribution of value to negative feedback. This imbalance in feedback sensitivity can be measured using the probabilistic reversal-learning (PRL) task. This task was initially designed for clinical research, but introduction of its rodent version provides a new and much needed translational paradigm to evaluate potential novel antidepressants. OBJECTIVES: In the present study, we aimed at evaluating the effects of a compound showing clear antidepressant properties-ketamine (KET)-on the sensitivity of rats to positive and negative feedback in the PRL paradigm...
December 8, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27933179/associations-between-genetics-medical-status-physical-exercise-and-psychological-well-being-in-adults-with-cystic-fibrosis
#4
Lena Backström-Eriksson, Agneta Bergsten-Brucefors, Lena Hjelte, Bo Melin, Kimmo Sorjonen
BACKGROUND: Cystic fibrosis (CF) is the most common autosomal recessive, life-shortening disease among people of European origin. Type of genetic mutation and regular physical exercise has an impact on clinical outcome. This cross-sectional study explores the associations between genetics, medical status, physical exercise and psychological well-being in adult patients with CF. METHODS: Adult patients with CF (N=68; mean age: 32.2; range 18-67 years; 46% women) completed the Cystic Fibrosis Questionnaire-Revised and Hospital Anxiety Depression Scale...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27932945/monoaminergic-and-histaminergic-strategies-and-treatments-in-brain-diseases
#5
REVIEW
Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J Smolders, Anna Stasiak, Wieslawa A Fogel, Philippe De Deurwaerdère
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27932864/efficacy-and-tolerability-of-vilazodone-for-major-depressive-disorder-evidence-from-phase-iii-iv-randomized-controlled-trials
#6
Ligen Shi, Jingyi Wang, Shenbin Xu, Yunrong Lu
Vilazodone is a new molecule approved for major depressive disorder (MDD). This report focuses on the efficacy and tolerability of vilazodone for MDD. MEDLINE, EMBASE, and Cochrane Library were searched. A total of 1,930 patients from four trials were included. A significant improvement in the Montgomery-Asberg Depression Rating Scale (MADRS) total score was seen as early as week 2 (P<0.01) in vilazodone-treated patients. The results showed a higher rate of MADRS response with vilazodone compared with placebo (P<0...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27932603/poststroke-depression-a-scientific-statement-for-healthcare-professionals-from-the-american-heart-association-american-stroke-association
#7
Amytis Towfighi, Bruce Ovbiagele, Nada El Husseini, Maree L Hackett, Ricardo E Jorge, Brett M Kissela, Pamela H Mitchell, Lesli E Skolarus, Mary A Whooley, Linda S Williams
Poststroke depression (PSD) is common, affecting approximately one third of stroke survivors at any one time after stroke. Individuals with PSD are at a higher risk for suboptimal recovery, recurrent vascular events, poor quality of life, and mortality. Although PSD is prevalent, uncertainty remains regarding predisposing risk factors and optimal strategies for prevention and treatment. This is the first scientific statement from the American Heart Association on the topic of PSD. Members of the writing group were appointed by the American Heart Association Stroke Council's Scientific Statements Oversight Committee and the American Heart Association's Manuscript Oversight Committee...
December 8, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27931909/the-big-five-personality-dimensions-and-mental-health-the-mediating-role-of-alexithymia
#8
Mohammad Atari, Mahsa Yaghoubirad
The role of personality constructs on mental health has attracted research attention in the last few decades. The Big Five personality traits have been introduced as parsimonious dimensions of non-pathological traits. The five-factor model of personality includes neuroticism, agreeableness, conscientiousness, extraversion, and openness to experience. The present study aimed to examine the relationship between the Big Five dimensions and mental health considering the mediating role of alexithymia as an important emotional-processing construct...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931907/return-of-the-psychedelics-psilocybin-for-treatment-resistant-depression
#9
Suravi Patra
Psilocybin, the clinically most researched classic psychedelic has recently been tested for its safety and efficacy in a clinical population of treatment resistant depression. The efficacy of psilocybin in clinical depression previously demonstrated in the elecrophysiologic and neuroimaging findings as also in neuropsychological assessments is further validated by the findings of this rigorously conducted randomized trial. Mechanism of action of psilocybin and efficacy in treatment resistant depression are discussed in this paper...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931906/burnout-in-japanese-residents-and-its-associations-with-temperament-and-character
#10
Ryoei Miyoshi, Hisae Matsuo, Ryuichiro Takeda, Hiroyuki Komatsu, Hiroshi Abe, Yasushi Ishida
AIM: High risk of burnout in healthcare workers has long been recognized. However, there are no methods to predict vulnerability to burnout. METHODS: We examined whether temperament and character are associated with burnout and depressive state in residents by using the Temperament and Character Inventory (TCI). The TCI was used for residents at the beginning of clinical training and then the Maslach Burnout Inventory-General Survey (MBI-GS) and the Self-Rating Depression Scale (SDS) were administered at the beginning of clinical training and after four and ten months...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931900/dimensions-of-schizophrenia-and-their-time-course-of-response-to-a-second-generation-antipsychotic-olanzapine-a-clinical-study
#11
Badari Birur, Jagadisha Thirthalli, N Janakiramaiah, Richard C Shelton, Bangalore N Gangadhar
BACKGROUND: The pattern of symptom response to second generation antipsychotics (SGAs) has not been studied extensively. Understanding the time course of symptom response would help to rationally monitor patient progress. OBJECTIVE: To determine the short-term differential time course of response of symptom dimensions of first episode schizophrenia viz., negative, positive symptoms and 5 factors of anergia, thought disturbance, activation, paranoid-belligerence and depression to treatment with SGA olanzapine...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931880/predictive-diagnosis-of-major-depression-using-nmr-based-metabolomics-and-least-squares-support-vector-machine
#12
Hong Zheng, Peng Zheng, Liangcai Zhao, Jianmin Jia, Shengli Tang, Pengtao Xu, Peng Xie, Hongchang Gao
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment and management of the MD, but so far no such technique exists. We developed an integrated analytical method of NMR-based metabolomics and least squares-support vector machine (LS-SVM) for predictive diagnosis of the MD. METHODS: The metabolite profiles in clinical plasma samples obtained from 72 depressive patients and 54 healthy subjects were analyzed by NMR spectroscopy...
December 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27931301/corticosteroid-related-toxicity-in-patients-with-chronic-idiopathic-urticariachronic-spontaneous-urticaria
#13
Dennis Ledford, Michael S Broder, Evgeniya Antonova, Theodore A Omachi, Eunice Chang, Allan Luskin
BACKGROUND: Treatments for patients with chronic idiopathic urticaria (CIU)chronic spontaneous urticaria (CSU) who were unresponsive to antihistamines include oral corticosteroids (OCS). Risks of OCS-related side effects in these patients have not been described quantitatively. OBJECTIVE: To investigate the relationship between OCS use and the risk of developing side effects possibly attributable to OCS and associated health care costs in privately insured patients with CIU/CSU...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27931248/postpartum-depression-and-infant-feeding-practices-in-a-low-income-urban-settlement-in-nairobi-kenya
#14
Beatrice A Madeghe, Violet N Kimani, Ann Vander Stoep, Semret Nicodimos, Manasi Kumar
BACKGROUND: Postpartum depression can compromise caregiving activities, including infant feeding practices, resulting in child malnutrition. The purpose of this study was to examine the effects of postpartum depression on infant feeding practices and malnutrition among women in an urban low income settlement in Nairobi-Kenya. We conducted a cross-sectional study based in Kariobangi North Health Centre in Nairobi County. The study sample included 200 mother-infant pairs visiting the Maternal and Child Health clinics for infant immunization at 6-14 weeks postpartum...
December 8, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27930966/nonsuicidal-self-injury-and-interpersonal-violence-in-u-s-veterans-seeking-help-for-posttraumatic-stress-disorder
#15
Patrick S Calhoun, Elizabeth E Van Voorhees, Eric B Elbogen, Eric A Dedert, Carolina P Clancy, Lauren P Hair, Michael Hertzberg, Jean C Beckham, Nathan A Kimbrel
Nonsuicidal self-injury (NSSI) has been defined as deliberately damaging one's body tissue without conscious suicidal intent. NSSI is a robust predictor of suicidal ideation and attempts in adults. While NSSI has been associated with other-directed violence in adolescent populations, the link between NSSI and interpersonal violence in adults is less clear. The current study examined the cross-sectional relationship between NSSI and past-year interpersonal violence among 729 help-seeking veterans with posttraumatic stress disorder (PTSD)...
November 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27930952/prevalence-and-psychosocial-correlates-of-food-addiction-in-persons-with-obesity-seeking-weight-reduction
#16
Ariana M Chao, Jena A Shaw, Rebecca L Pearl, Naji Alamuddin, Christina M Hopkins, Zayna M Bakizada, Robert I Berkowitz, Thomas A Wadden
INTRODUCTION: Food addiction is a controversial concept. The potential influence of food addiction on patients' psychosocial functioning and well-being has not been well established. The purpose of this study was to examine the relationships between psychosocial functioning (depressive symptoms and health-related quality of life [HRQOL]) and food addiction as measured by the Yale Food Addiction Scale (YFAS). We also explored whether food addiction contributed additional variance in explaining psychosocial functioning, beyond demographic and clinical factors (e...
November 23, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27930951/symptom-correspondence-between-clinicians-and-patients-on-the-yale-brown-obsessive-compulsive-scale
#17
Eric A Storch, Joshua M Nadeau, Alessandro S De Nadai, Sandra L Cepeda, Bradley C Riemann, Philip Seibell, Brian Kay
The present study examined concordance between the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and its self-report version (Y-BOCS-SR), as well as theoretically derived moderators. Sixty-seven adults (ages 18-67) with obsessive-compulsive disorder (OCD) were administered the Y-BOCS prior to completing self-report measures. The Y-BOCS-SR generated lower scores relative to the clinician-administered Y-BOCS (5.3 points lower). Strong correspondence was shown between the Y-BOCS and Y-BOCS-SR; however, many items exhibited fair to moderate agreement, particularly the resistance and control against obsessions/compulsions items...
November 30, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27930916/depressiveness-measured-with-beck-depression-inventory-in-patients-with-psoriasis
#18
Daniel Pietrzak, Aldona Pietrzak, Dorota Krasowska, Marta Makara-Studzińska, Agata Madej, Maja Baranowska, Andrzej Borzęcki
BACKGROUND: The aim of this study was to identify demographic and clinical factors predisposing to depressiveness during the course of psoriasis. METHOD: The study included 239 patients with psoriasis (15-76 years, 31.8% of women) and 123 healthy controls (17-74 years, 32.5% of women). Dependent variable in the analysis was Beck Depression Inventory (BDI) score. Explanatory variables included: age, sex, marital status, education, occupational activity, body mass index (BMI), systolic and diastolic blood pressure, history of smoking, average number of smoked cigarettes, skin lesions visible to others, comorbidities, including arterial hypertension and arthritis, number of previous hospitalizations and family history of psoriasis...
November 30, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27930912/poor-sleep-quality-antepartum-depression-and-suicidal-ideation-among-pregnant-women
#19
Bizu Gelaye, Gifty Addae, Beemnet Neway, Gloria T Larrabure-Torrealva, Chunfang Qiu, Lee Stoner, Miguel Angel Luque Fernandez, Sixto E Sanchez, Michelle A Williams
OBJECTIVE: To evaluate the independent and combined associations of maternal self-reported poor sleep quality and antepartum depression with suicidal ideation during the third trimester METHODS: A cross-sectional study was conducted among 1298 pregnant women (between 24 and 28 gestational weeks) attending prenatal clinics in Lima, Peru. Antepartum depression and suicidal ideation were assessed using the Patient Health Questionnaire-9 (PHQ-9). The Pittsburgh Sleep Quality Index (PSQI) questionnaire was used to assess sleep quality...
November 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27930857/psychosocial-adaptation-and-depressive-manifestations-in-high-risk-pregnant-women-implications-for-clinical-practice
#20
Gamze Fiskin, Meltem Mecdi Kaydirak, Umran Yesiltepe Oskay
BACKGROUND: High-risk pregnancy research has focused primarily on psychological well-being. AIMS: The aim is to determine psychosocial adaptation and depression levels of pregnant women who were admitted to hospital with diagnosis of high-risk pregnancy. METHODS: This study was descriptive. Sampling was composed of 122 high-risk pregnant women who were hospitalized in the perinatology service of Istanbul University Medical School, Department of Obstetrics and Gynecology between January 1, 2014, and May 31, 2014, and met the study criteria...
December 8, 2016: Worldviews on Evidence-based Nursing
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