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https://www.readbyqxmd.com/read/28227698/predicting-brain-stimulation-treatment-outcomes-of-depressed-patients-through-the-classification-of-eeg-oscillations
#1
Alaa M Al-Kaysi, Ahmed Al-Ani, Colleen K Loo, Michael Breakspear, Tjeerd W Boonstra, Alaa M Al-Kaysi, Ahmed Al-Ani, Colleen K Loo, Michael Breakspear, Tjeerd W Boonstra, Michael Breakspear, Ahmed Al-Ani, Tjeerd W Boonstra, Colleen K Loo
Major depressive disorder (MDD) is a mental disorder that is characterized by negative thoughts, mood and behavior. Transcranial direct current stimulation (tDCS) has recently emerged as a promising brain-stimulation treatment for MDD. A standard tDCS treatment involves numerous sessions that run over a few weeks, however, not all participants respond to this type of treatment. This study aims to predict which patients improve in mood and cognition in response to tDCS treatment by analyzing electroencephalography (EEG) of MDD patients that was collected at the start of tDCS treatment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226968/discriminating-clinical-phases-of-recovery-from-major-depressive-disorder-using-the-dynamics-of-facial-expression
#2
Sahar Harati, Andrea Crowell, Helen Mayberg, Jun Kong, Shamim Nemati, Sahar Harati, Andrea Crowell, Helen Mayberg, Jun Kong, Shamim Nemati, Andrea Crowell, Helen Mayberg, Jun Kong, Shamim Nemati, Sahar Harati
We used several metrics of variability to extract unsupervised features from video recordings of patients before and after deep brain stimulation (DBS) treatment for major depressive disorder (MDD). Our goal was to quantify the treatment effects on facial expressivity. Multiscale entropy (MSE) was used to capture the temporal variability in pixel intensity level at multiple time-scales. A dynamic latent variable model (DLVM) was used to learn a low dimensional (D = 20) set of dynamic factors that explain the observed covariance across the high-dimensional pixels (M = 30 × 30) within each video frame and across time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226871/identifying-depressed-patients-with-and-without-suicidal-ideation-by-finger-photo-plethysmography
#3
A H Khandoker, V Luthra, Y Abouallaban, S Saha, K I Ahmed, R Mostafa, N Chowdhury, H F Jelinek, A H Khandoker, V Luthra, Y Abouallaban, S Saha, K I Ahmed, R Mostafa, N Chowdhury, H F Jelinek, A H Khandoker, R Mostafa, H F Jelinek, N Chowdhury, Y Abouallaban, S Saha, K I Ahmed, V Luthra
Major Depressive Disorder (MDD) is a serious mental disorder that if untreated not only affects physical health but also has a high risk of suicide. While the neurophysiological phenomena that contribute to the formation of Suicidal Ideation (SI) are still ill-defined, clear links between MDD and cardiovascular disease have been reported. The aim of this study is to extract suitable features from arterial pulse signals with a view to predicting SI within MDD and control groups. Sixteen unmedicated MDD patients with a history of SI (MDDSI+), sixteen without SI (MDDSI-) and twenty-nine healthy subjects (CONT) were recruited at a psychiatric clinic in the UAE...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226863/synaptic-depression-depends-on-charge-delivered-to-network
#4
Robert D Graham, Sharon Jose, Alex Kaiser, Nathalia Peixoto, Robert D Graham, Sharon Jose, Alex Kaiser, Nathalia Peixoto, Sharon Jose, Alex Kaiser, Robert D Graham, Nathalia Peixoto
In vitro neuronal networks cultured on microelectrode arrays enable the study of network electrophysiology on a fundamental level. Neuronal response to electrical stimulation is an area of interest at the laboratory bench and in the clinic, given its wide application for remedying neurological disorders. Here we investigated the change in cortical network response over time to varied amounts of charge used for stimulation, which may lead to a phenomenon known as selective adaptation. There is a charge threshold that invokes a reverberating network response; when stimulating at 900 mV, five stimulation electrodes were required to elicit a response across the entire network...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226853/generalized-binary-noise-stimulation-enables-time-efficient-identification-of-input-output-brain-network-dynamics
#5
Yuxiao Yang, Maryam M Shanechi, Yuxiao Yang, Maryam M Shanechi, Yuxiao Yang, Maryam M Shanechi
Identification of input-output (IO) dynamics of brain networks in response to electrical stimulation is essential for devising closed-loop therapies for neurological disorders such as major depression. A critical component for accurate IO identification is the stimulation input design. The time available for open-loop stimulation to perform system identification is typically limited. While our prior design of a binary noise (BN) modulated input pattern satisfies the requirements for optimal identification and clinical safety, it does not incorporate any prior information about the underlying network...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226415/topographical-pressure-pain-sensitivity-maps-of-the-temporalis-muscle-in-people-with-frequent-episodic-and-chronic-tension-type-headache
#6
María Palacios Ceña, Matteo Castaldo, Kelun Wang, Pascal Madeleine, Ángel L Guerrero, Lars Arendt-Nielsen, César Fernández de Las Peñas
BACKGROUND: Previous pilot studies suggest the presence of heterogeneous sensitivity to pressure in primary headaches without considering the frequency of headache episodes. OBJECTIVE: To investigate the differences in topographical pressure pain sensitivity maps in the temporalis muscle between individuals with frequent episodic (FETTH) and chronic (CTTH) tension-type headache by controlling the presence of anxiety and depression. METHODS: Pressure pain thresholds (PPTs) were assessed bilaterally from 9 points distributed over the temporalis muscle (3 points in the anterior portion, 3 in the middle portion, and the remaining 3 in the posterior portion of the muscle belly) in 113 patients with FETTH and 91 with CTTH in a blinded design...
February 22, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28225970/trichotillomania-a-case-report-with-clinical-and-dermatoscopic-differential-diagnosis-with-alopecia-areata
#7
Ana Cecília Versiani Duarte Pinto, Tatiana Cristina Pedro Cordeiro de Andrade, Fernanda Freitas de Brito, Gardênia Viana da Silva, Maria Lopes Lamenha Lins Cavalcante, Antonio Carlos Ceribelli Martelli
Trichotillomania is a psychodermatologic disorder characterized by uncontrollable urge to pull one's own hair. Differential diagnoses include the most common forms of alopecia such as alopecia areata. It is usually associated with depression and obsessive-compulsive disorder. Trichotillomania treatment standardization is a gap in the medical literature. Recent studies demonstrated the efficacy of N-acetylcysteine (a glutamate modulator) for the treatment of the disease. We report the clinical case of a 12-year-old female patient who received the initial diagnosis of alopecia areata, but presented with clinical and dermoscopic features of trichotillomania...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28225747/effect-of-methylphenidate-on-emotional-dysregulation-in-children-with-attention-deficit-hyperactivity-disorder-oppositional-defiant-disorder-conduct-disorder
#8
Ayse Kutlu, Ulku Akyol Ardic, Eyup Sabri Ercan
BACKGROUND AND AIM: Emotional dysregulation (ED) is a frequent feature of attention-deficit/hyperactivity disorder (ADHD). It can be observed as a dysregulation profile or a deficient emotional self-regulation (DESR) profile. Oppositional defiant disorder/conduct disorder (ODD/CD) comorbidity is prevalent in ADHD and known to be related with ED. The first-line treatment of ADHD includes psychostimulants, but their effects on ED are not well studied. This study aimed to evaluate the outcomes of methylphenidate (MPH) treatment on ED in ADHD + ODD/CD cases...
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28225710/chronic-stress-exacerbates-neuropathic-pain-via-the-integration-of-stress-affect-related-information-with-nociceptive-information-in-the-central-nucleus-of-the-amygdala
#9
Ming-Jia Li, Ling-Yu Liu, Lin Chen, Jie Cai, You Wan, Guo-Gang Xing
Exacerbation of pain by chronic stress and co-morbidity of pain with stress-related psychiatric disorders including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim (FS) stress-induced exacerbation of neuropathic pain is mediated by the integration of stress-affect related information with nociceptive information in the central nucleus of the amygdala (CeA). We first demonstrated that chronic FS stress (CFSS) indeed produces both depressive-like behaviors and exacerbation of spared nerve injury (SNI)-induced mechanical allodynia in rats...
December 29, 2016: Pain
https://www.readbyqxmd.com/read/28225508/suicidal-ideation-vs-suicide-attempts-clinical-and-psychosocial-profile-differences-among-depressed-patients-a-study-on-personality-traits-psychopathological-variables-and-sociodemographic-factors-in-228-patients
#10
Ute Lewitzka, Sina Spirling, Dirk Ritter, Michael Smolka, Sarah Goodday, Michael Bauer, Werner Felber, Tom Bschor
This study investigated whether personality traits, psychopathological characteristics, and sociodemographic factors in depressed patients differentiate patients with only suicidal thoughts from those who have attempted suicide. We investigated two groups of patients with an affective disorder: 198 patients with a suicide attempt within the last 3 months (sex ratio male to female, 1:1.3; mean age male to female, 44.8/44.7 years) and 30 patients without a suicide attempt but with suicidal thoughts (sex ratio male to female, 1:2; mean age male to female, 39...
February 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28225374/characterizing-the-toxicity-and-dose-effect-profile-of-tramadol-ingestions-in-children
#11
Gina L Stassinos, Lawrence Gonzales, Wendy Klein-Schwartz
OBJECTIVES: Tramadol can cause life-threatening toxicity in overdose; however, data on its toxicity in children are lacking. This study investigates toxicity associated with tramadol ingestions in children. The hypothesis is that children will experience dose-related central nervous system and respiratory depression and seizures. METHODS: A retrospective evaluation of cases from the National Poison Center Data System between January 1, 2000, and December 31, 2013, was performed...
February 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28225086/uvrag-deficiency-exacerbates-doxorubicin-induced-cardiotoxicity
#12
Lin An, Xiao-Wen Hu, Shasha Zhang, Xiaowen Hu, Zongpei Song, Amber Naz, Zhenguo Zi, Jian Wu, Can Li, Yunzeng Zou, Lin He, Hongxin Zhu
Doxorubicin (DOX) is an effective chemotherapeutic drug in the treatment of various types of cancers. However, its clinical application has been largely limited by potential development of cardiotoxicity. Previously we have shown that ultra-violet radiation resistance-associated gene (UVRAG), an autophagy-related protein, is essential for the maintenance of autophagic flux in the heart under physiological conditions. Here, we sought to determine the role of UVRAG-mediated autophagy in DOX-induced cardiotoxicity...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28225048/thiamine-deficiency-oxidative-metabolic-pathways-and-ethanol-induced-neurotoxicity-how-poor-nutrition-contributes-to-the-alcoholic-syndrome-as-marchiafava-bignami-disease
#13
REVIEW
L M P Fernandes, F R Bezerra, M C Monteiro, M L Silva, F R de Oliveira, R R Lima, E A Fontes-Júnior, C S F Maia
Ethanol is an important risk factor for the occurrence of several brain disorders that depend on the amount, period and frequency of its consumption. Chronic use of ethanol often leads to the development of neurodegenerative syndromes, which cause morphological and functional impairments such as foetal alcohol syndrome in newborns exposed to ethanol during pregnancy, Wernicke-Korsakoff Syndrome and, more rarely, Marchiafava-Bignami disease (MBD). MBD is characterized by primary degeneration of the corpus callosum, without inflammation and is associated with oxidative stress and hypovitaminosis, as well as altered mental status, to mention dementia, seizures, depression and so on...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28224881/avoidance-in-anxiety-and-depression-adaptation-of-the-cognitive-behavioral-avoidance-scale-in-a-spanish-sample
#14
Santiago Barajas, Luis Garra, Laura Ros
This study examines how cognitive, behavioral and experiential avoidance differs between clinical patients (N = 100), the general population (N = 100), and undergraduate students (N = 54). For this purpose, a Spanish adaptation of the Cognitive-Behavioral Avoidance Scale (CBAS; Ottenbreit & Dobson, 2004) was made. Confirmatory factor analysis supports the four factors structure similar to the original one, yet question the value of three of the items (CFI = .929, RMSEA = .057, SRMR = .051, χ2(333) = 603.28, p < ...
February 22, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28224880/child-depression-prevalence-and-comparison-between-self-reports-and-teacher-reports
#15
Joana Jaureguizar, Elena Bernaras, Maite Garaigordobil
Depression is one of the most worrying diseases nowadays. The study had three main purposes: 1) to identify the prevalence of depressive symptomatology in 7-10 year olds, exploring differences according to gender and age; 2) to analyze the consistency between self-reports and teacher reports; and 3) to explore the relationship between depression and academic performance. Regarding the methodology, the sample comprised 420 students aged between 7 and 10 years from the Basque Country (53.3% boys, 46.7% girls)...
February 22, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28224818/adjunctive-low-dose-docosahexaenoic-acid-dha-for-major-depression-an-open-label-pilot-trial
#16
Deidre J Smith, Jerome Sarris, Nathan Dowling, Manjula O'Connor, Chee H Ng
OVERVIEW: Whilst the majority of evidence supports the adjunctive use of eicosapentaenoic acid (EPA) in improving mood, to date no study exists using low-dose docosahexaenoic acid (DHA) alone as an adjunctive treatment in patients with mild to moderate major depressive disorder (MDD). METHODS: A naturalistic 8-week open-label pilot trial of low-dose DHA, (260 mg or 520 mg/day) in 28 patients with MDD who were non-responsive to medication or psychotherapy, with a Hamilton Depression Rating Scale (HAM-D) score of greater than 17, was conducted...
February 22, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28224713/internet-delivered-obesity-treatment-improves-symptoms-of-and-risk-for-depression
#17
Jacob Naparstek, Rena R Wing, Xiaomeng Xu, Tricia M Leahey
OBJECTIVE: In-person lifestyle interventions for obesity treatment yield significant improvements in depression. These improvements may be attributed to the excellent weight losses produced by in-person interventions. In contrast, Internet programs yield more modest weight losses, and their effect on depression is unknown. This study is the first to examine whether Internet-delivered obesity treatment impacts depressive symptoms. METHODS: Participants (N = 136) were randomized to either a community campaign plus Internet behavioral weight loss (IBWL) or community campaign alone (Control)...
February 22, 2017: Obesity
https://www.readbyqxmd.com/read/28224378/depression-and-anxiety-behaviour-in-a-rat-model-of-chronic-migraine
#18
Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong, Shengyuan Yu
BACKGROUND: Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals. METHODS: A classical chronic migraine rat model (repeated dura mater inflammatory soup [IS] infusion) was used to evaluate depression and anxiety behaviour via weight, sucrose preference test, open field test and elevated plus maze test. RESULTS: We found that sucrose preference, locomotor and rearing behaviours, inner zoon distance percent, open-arm entries percent and serotonin and dopamine levels in the prefrontal cortex decreased significantly in the IS group compared with those in the control group; co-administration of low-dose amitriptyline ameliorated these deficits...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28223841/benzodiazepine-use-in-patients-with-chronic-pain-in-an-interdisciplinary-pain-rehabilitation-program
#19
Julie L Cunningham, Julia R Craner, Michele M Evans, W Michael Hooten
OBJECTIVES: In the context of widespread opioid use, increased emphasis has been placed on the potentially deleterious effects of concurrent benzodiazepine (BZD) and opioid use. Although use of opioids in chronic pain has been a major focus, BZD use is equally concerning. Thus, the primary aim of this study was to determine the associations between BZD and opioid use in adults with chronic pain upon admission to an outpatient interdisciplinary pain rehabilitation (IPR) program. METHODS: The study cohort involved 847 consecutive patients admitted to a 3-week outpatient IPR program from January 2013 through December 2014...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28223809/a-review-of-the-efficacy-of-atomoxetine-in-the-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adult-patients-with-common-comorbidities
#20
REVIEW
David B Clemow, Chris Bushe, Michele Mancini, Michael H Ossipov, Himanshu Upadhyaya
Attention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder that is often diagnosed during childhood, but has also increasingly been recognized to occur in adults. Importantly, up to 52% of children (including adolescents) and 87% of adults with ADHD also have a comorbid psychiatric disorder. The presence of a comorbid disorder has the potential to impact diagnosis and could affect treatment outcomes. Atomoxetine is a nonstimulant treatment for ADHD. Despite numerous published studies regarding efficacy of atomoxetine in the treatment of ADHD in patients with comorbid disorders, there is limited information about the impact of individual common comorbid disorders on the efficacy of atomoxetine for ADHD, especially with regard to adults...
2017: Neuropsychiatric Disease and Treatment
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