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https://www.readbyqxmd.com/read/29691834/prescription-and-predictors-of-post-stroke-antidepressant-treatment-a-population-based-study
#1
J K Mortensen, S P Johnsen, G Andersen
OBJECTIVES: Post-stroke depression and pathological crying are common and potentially serious complications after stroke and should be diagnosed and treated accordingly. Diagnosis and treatment probably rely on clinical experience and may pose certain challenges. We aimed to examine prescription and predictors of antidepressant treatment after ischemic stroke in a clinical setting. MATERIALS AND METHODS: In this registry-based follow-up study, consecutive ischemic stroke patients were identified from the Danish Stroke Registry, holding information on antidepressant treatment during admission in Aarhus County from 2003 to 2010...
April 24, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29691245/health-related-quality-of-life-in-chinese-inpatients-with-lung-cancer-treatedin-large-general-hospitals-across-sectional-study
#2
Wen Gu, Yan-Min Xu, Bao-Liang Zhong
OBJECTIVE: In China, psychosocial problems of patients with cancer are under-recognised and undertreated in medical oncology practice. This study examined the health-related quality of life (QOL) in inpatients with lung cancer treated in large general hospitals and explored the demographic, clinical and psychosocial factors associated with QOL. DESIGN: Cross-sectional study. PARTICIPANTS AND SETTING: Altogether, 148 inpatients with lung cancer were consecutively recruited from two large general hospitals in Tianjin, China...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29690858/effects-of-menopausal-symptoms-and-depression-on-the-quality-of-life-of-premenopausal-women-with-breast-cancer-in-korea
#3
Jeong Ae Han, So Young Choi, Seonah Lee
INTRODUCTION: As breast cancer survivors have increased, improving quality of life of the survivors becomes an important issue. The purpose of this study was to examine relationships among menopausal symptoms, depression, and quality of life and to identify the factors affecting the quality of life in premenopausal women with breast cancer. METHOD: This was a descriptive, correlational study using structured questionnaires for 90 premenopausal women with breast cancer attending the outpatient clinic of a tertiary hospital in Korea...
April 1, 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29690793/clinical-implementation-of-pharmacogenetic-decision-support-tools-for-antidepressant-drug-prescribing
#4
Zane Zeier, Linda L Carpenter, Ned H Kalin, Carolyn I Rodriguez, William M McDonald, Alik S Widge, Charles B Nemeroff
The accrual and analysis of genomic sequencing data have identified specific genetic variants that are associated with major depressive disorder. Moreover, substantial investigations have been devoted to identifying gene-drug interactions that affect the response to antidepressant medications by modulating their pharmacokinetic or pharmacodynamic properties. Despite these advances, individual responses to antidepressants, as well as the unpredictability of adverse side effects, leave clinicians with an imprecise prescribing strategy that often relies on trial and error...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690792/physical-activity-and-incident-depression-a-meta-analysis-of-prospective-cohort-studies
#5
Felipe B Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Phillip B Ward, Edson S Silva, Mats Hallgren, Antonio Ponce De Leon, Andrea L Dunn, Andrea C Deslandes, Marcelo P Fleck, Andre F Carvalho, Brendon Stubbs
OBJECTIVE: The authors examined the prospective relationship between physical activity and incident depression and explored potential moderators. METHOD: Prospective cohort studies evaluating incident depression were searched from database inception through Oct. 18, 2017, on PubMed, PsycINFO, Embase, and SPORTDiscus. Demographic and clinical data, data on physical activity and depression assessments, and odds ratios, relative risks, and hazard ratios with 95% confidence intervals were extracted...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690783/prevalence-of-depressive-syndrome-and-their-association-with-demographic-and-clinical-characteristics-in-chinese-hiv-patients
#6
Yuan-Yuan Wang, Jin Zhao, Qinge Zhang, Yan Zhang, Baolian Bai, Chee H Ng, Gabor S Ungvari, Fu-Jun Jia, Yu-Tao Xiang
To investigate the prevalence of depressive syndrome and their association with demographic and clinical characteristics in Chinese patients infected with the human immunodeficiency virus (HIV). A total of 416 patients with HIV infection were consecutively screened and enrolled in the study. Depressive syndrome was assessed with the Center for Epidemiologic Studies-Depression Scale (CES-D). The proportion of depressive syndrome was 36.3%. Patients with depressive syndrome were younger, and were more likely to have severe anxiety symptoms, religious beliefs and psychological treatment...
April 24, 2018: AIDS Care
https://www.readbyqxmd.com/read/29690736/-observation-on-safety-and-effects-of-analgesic-and-sedative-treatment-in-severely-burned-patients-during-shock-stage
#7
R B Li, Q Chen, H Y Zhang, H A Deng, G H Guo, Y G Mao, Z H Fu
Objective: To observe the safety and effects of application of analgesic and sedative drugs in severely burned patients during shock stage. Methods: One hundred and eighty patients with severe burns, conforming to the study criteria, were admitted to our unit from August 2014 to August 2016. Patients were divided into analgesia and sedation group and control group according to whether receiving analgesic and sedative treatment or not, with 90 cases in each group. Patients in control group received conventional treatment, while those in analgesia and sedation group received analgesic and sedative treatment for 24 hours besides conventional treatment...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29689760/joint-regression-and-classification-via-relational-regularization-for-parkinson-s-disease-diagnosis
#8
Haijun Lei, Zhongwei Huang, Tao Han, Qiuming Luo, Ye Cai, Gang Liu, Baiying Lei
It is known that the symptoms of Parkinson's disease (PD) progress successively, early and accurate diagnosis of the disease is of great importance, which slows the disease deterioration further and alleviates mental and physical suffering. In this paper, we propose a joint regression and classification scheme for PD diagnosis using baseline multi-modal neuroimaging data. Specifically, we devise a new feature selection method via relational learning in a unified multi-task feature selection model. Three kinds of relationships (e...
April 10, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29689719/the-behavioral-and-psychological-symptoms-of-dementia-in-down-syndrome-bpsd-ds-scale-comprehensive-assessment-of-psychopathology-in-down-syndrome
#9
Alain D Dekker, Silvia Sacco, Angelo Carfi, Bessy Benejam, Yannick Vermeiren, Gonny Beugelsdijk, Mieke Schippers, Lyanne Hassefras, José Eleveld, Sharina Grefelman, Roelie Fopma, Monique Bomer-Veenboer, Mariángeles Boti, G Danielle E Oosterling, Esther Scholten, Marleen Tollenaere, Laura Checkley, André Strydom, Gert Van Goethem, Graziano Onder, Rafael Blesa, Christine Zu Eulenburg, Antonia M W Coppus, Anne-Sophie Rebillat, Juan Fortea, Peter P De Deyn
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689718/subjective-cognitive-decline-objective-cognition-and-depression-in-older-hispanics-screened-for-memory-impairment
#10
Zvinka Z Zlatar, Martha C Muniz, Sarah Espinoza, Roberto Gratianne, Tamar H Gollan, Douglas Galasko, David P Salmon
Subjective cognitive decline (SCD) is common in older adults and may be an early marker of future cognitive decline. Research suggest that SCD is more closely related to concurrent symptoms of depression than to objective cognitive performance in non-Hispanic Whites, but it is unknown whether the associations of SCD, cognition, and depression manifest differently in Hispanic older adults. We examined if SCD is associated with objective cognitive performance or with depression symptoms in 145 Hispanic individuals ages 60 or older referred by community health clinics for screening of cognitive complaints...
April 14, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689693/vortioxetine-improves-symptomatic-and-functional-outcomes-in-major-depressive-disorder-a-novel-dual-outcome-measure-in-depressive-disorders
#11
Michael Cronquist Christensen, Henrik Loft, Roger S McIntyre
BACKGROUND: With symptomatic remission and functional recovery as the overarching therapeutic objectives of antidepressant therapy, composite endpoint measures that conjointly consider both aspects of treatment are needed. This analysis evaluated the combined effect of vortioxetine on depressive symptoms and functional capacity in adults with MDD. METHODS: NCT01564862, a multinational, double-blind, placebo-controlled, duloxetine-referenced study, conducted between April 2012 and February 2014, in 602 adult outpatients (18-65 years) with moderate-to-severe MDD (Montgomery-Åsberg Depression Rating Scale (MADRS) ≥ 26), a major depressive episode of ≥ 3 months' duration, and self-reported cognitive symptoms were randomized to once-daily vortioxetine (10 or 20mg), duloxetine (60mg), or placebo for 8 weeks...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29689597/the-predictive-value-of-approach-and-avoidance-tendencies-on-the-onset-and-course-of-depression-and-anxiety-disorders
#12
Sascha Y Struijs, Femke Lamers, Mike Rinck, Karin Roelofs, Philip Spinhoven, Brenda W J H Penninx
BACKGROUND: Trait and automatic approach-avoidance (AA) tendencies are central concepts in research on affective disorders. We longitudinally examined the associations of trait and automatic AA tendencies with the risk of onset and chronicity of anxiety and depressive disorders. METHODS: Participants were subdivided into those with (n = 766) versus without (n = 1,636) a current anxiety or depression diagnosis at baseline. Clinical diagnoses were reassessed after 2-year follow-up...
April 24, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29689499/is-subthreshold-bipolar-ii-disorder-more-difficult-to-differentiate-from-borderline-personality-disorder-than-formal-bipolar-ii-disorder
#13
Adam Bayes, Rebecca K Graham, Gordon B Parker, Stacey McCraw
Recent research indicates that borderline personality disorder (BPD) can be diagnostically differentiated from the bipolar disorders. However, no studies have attempted to differentiate participants with sub-threshold bipolar disorder or SubT BP (where hypomanic episodes last less than 4 days) from those with a BPD. In this study, participants were assigned a SubT BP, bipolar II disorder (BP II) or BPD diagnosis based on clinical assessment and DSM-IV criteria. Participants completed self-report measures and undertook a clinical interview which collected socio-demographic information, a mood history, family history, developmental history, treatment information, and assessed cognitive, emotional and behavioural functioning...
April 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29689036/-palliative-care-and-heart-failure-is-it-time-to-talk
#14
Massimo Romanò
Heart failure (HF) is one of the leading causes of hospitalization in high-income countries and has a profound negative impact on quality of life. In the United States there are more than 900,000 new cases per year and over one million hospital admissions with a primary diagnosis of HF. A prevalence of 6,500,000 cases (2.2% of the population of aged >20 years) was estimated for the US in 2014, in which there were 300,000 related deaths. Although survival has increased, thanks to the pharmacological and non pharmacological therapy, roughly 50% of HF patients die within 5 years of being diagnosed...
April 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29688573/antidepressants-for-the-treatment-of-people-with-co-occurring-depression-and-alcohol-dependence
#15
REVIEW
Roberta Agabio, Emanuela Trogu, Pier Paolo Pani
BACKGROUND: Alcohol dependence is a major public health problem characterized by recidivism, and medical and psychosocial complications. The co-occurrence of major depression in people entering treatment for alcohol dependence is common, and represents a risk factor for morbidity and mortality, which negatively influences treatment outcomes. OBJECTIVES: To assess the benefits and risks of antidepressants for the treatment of people with co-occurring depression and alcohol dependence...
April 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29688548/the-genetics-of-treatment-resistant-depression-a-critical-review-and-future-perspectives
#16
Chiara Fabbri, Filippo Corponi, Daniel Souery, Siegfried Kasper, Stuart Montgomery, Joseph Zohar, Dan Rujescu, Julien Mendlewicz, Alessandro Serretti
Background: One-third of depressed patients develop treatment-resistant depression with the related sequelae in terms of poor functionality and worse prognosis. Solid evidence suggests that genetic variants are potentially valid predictors of antidepressant efficacy and could be used to provide personalized treatments. Methods: The present review summarizes genetic findings of treatment-resistant depression including results from candidate gene studies and genome-wide association studies...
April 21, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29688469/perceived-illness-stigma-thwarted-belongingness-and-depressive-symptoms-in-youth-with-inflammatory-bowel-disease-ibd
#17
Kaitlyn L Gamwell, Marissa N Baudino, Dana M Bakula, Christina M Sharkey, Caroline M Roberts, John E Grunow, Noel J Jacobs, Stephen R Gillaspy, Larry L Mullins, John M Chaney
Background: Studies have begun to identify psychosocial factors associated with depressive symptoms in youth with IBD. However, despite considerable speculation in the literature regarding the role of perceived stigma in both social and emotional adjustment outcomes, youth appraisals of stigma have yet to receive empirical attention. The primary purpose of this study was to examine the indirect effect of perceived illness stigma on depressive symptoms through its impact on social belongingness...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688411/relevance-of-rodent-models-of-depression-in-clinical-practice-can-we-overcome-the-obstacles-in-translational-neuropsychiatry
#18
Johan Söderlund, Maria Lindskog
The diagnosis of a mental disorder generally depends on clinical observations and phenomenological symptoms reported by the patient. The definition of a given diagnosis is criteria based and relies on the ability to accurately interpret subjective symptoms and complex behavior. This type of diagnosis comprises a challenge to translate to reliable animal models, and these translational uncertainties hamper the development of new treatments. In this review, we will discuss how depressive-like behavior can be induced in rodents, and the relationship between these models and depression in humans...
April 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29688015/a-peripherally-restricted-purine-antagonist-of-type-1-cannabinoid-cb1-receptor-blocks-alcoholic-steatosis-in-mice
#19
George Amato, Amruta Manke, Danni L Harris, Robert W Wiethe, Vineetha Vasukuttan, Rodney W Snyder, Timothy W Lefever, Ricardo Cortes, Yanan Zhang, Shaobin Wang, Scott P Runyon, Rangan Maitra
Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome and dyslipidemias. However, inhibition of CB1 receptors in the central nervous system can produce adverse effects including depression, anxiety and suicidal ideation. Efforts are now underway to produce peripherally restricted CB1 antagonists to circumvent CNS-associated undesirable effects. In this study, a series of analogs were explored in which the 4-aminopiperidine group of 2 was replaced with aryl and heteroaryl substituted piperazine groups both with and without a spacer...
April 24, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29687966/spinal-manipulation-combined-with-laser-therapy-is-more-beneficial-than-laser-therapy-alone-in-chronic-non-specific-low-back-pain-a-randomized-controlled-study
#20
Gopal N Subash Chandra Bose, Walid Kamal, Shanmugananth Es, Siddhart Joshi, Parth Trivedi
BACKGROUND: Low back pain (LBP) is a common musculoskeletal disorder causing pain and disability in most of the countries. In recent years, new approaches such as Spinal manipulation and laser therapy have been considered as an alternative to conventional exercise and also found contradicting results in terms of its effectiveness. AIM: A study to compare the combined effects of spinal manipulation, Laser and exercise versus Laser and exercise alone in chronic non-specific low back pain (cnLBP)...
April 24, 2018: European Journal of Physical and Rehabilitation Medicine
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