Nick Corriveau-Lecavalier, Hugo Botha, Jonathan Graff-Radford, Aaron R Switzer, Scott A Przybelski, Heather J Wiste, Melissa E Murray, R Ross Reichard, Dennis W Dickson, Aivi T Nguyen, Vijay K Ramanan, Stuart J McCarter, Bradley F Boeve, Mary M Machulda, Julie A Fields, Nikki H Stricker, Peter T Nelson, Michel J Grothe, David S Knopman, Val J Lowe, Ronald C Petersen, Clifford R Jack, David T Jones
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neuropathologically-defined disease that affects 40% of persons in advanced age, but its associated neurological syndrome is not defined. LATE neuropathological changes (LATE-NC) are frequently comorbid with Alzheimer's disease neuropathologic changes (ADNC). When seen in isolation, LATE-NC have been associated with a predominantly amnestic profile and slow clinical progression. We propose a set of clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome (LANS) that is highly associated with LATE-NC but also other pathologic entities...
November 20, 2023: medRxiv