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https://www.readbyqxmd.com/read/28429905/maintenance-vitamin-d3-dosage-requirements-in-chinese-women-with-post-menopausal-osteoporosis-living-in-the-tropics
#1
Yogeswari Venugopal, Sharifah F Wan Muhamad Hatta, Nurbazlin Musa, Siti Abdul Rahman, Jeyakantha Ratnasingam, Sharmila Sunita Paramasivam, Lee Ling Lim, Luqman Ibrahim, Karen Choong, Alexander Tb Tan, Karuthan Chinna, Siew Pheng Chan, Shireene R Vethakkan
BACKGROUND AND OBJECTIVES: Vitamin D3 (cholecalciferol) dose required to maintain sufficiency in non- Caucasian women with postmenopausal osteoporosis (PMO) inthe tropics has not been well studied. Some guidelines mandate 800-1000 IU vitamin D/day but the Endocrine Society (US) advocates 1500-2000 IU/day to maintain 25-hydroxyvitamin-D (25(OH)D) concentration at >75 nmol/L. We aimed to establish oral cholecalciferol dose required to maintain 25(OH)D concentration at >75 nmol/L in PMO Chinese Malaysian women, postulating lower dose requirements amongst light-skinned subjects in the tropics...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28417313/impact-of-season-and-different-vitamin-d-thresholds-on-prevalence-of-vitamin-d-deficiency-in-epidemiological-cohorts-a-note-of-caution
#2
Sara Schramm, Harald Lahner, Karl-Heinz Jöckel, Raimund Erbel, Dagmar Führer, Susanne Moebus
PURPOSE: We investigated the impact of different cut-offs on the prevalence of 25-hydroxyvitamin D [25-(OH)D] deficiency. METHODS: We used baseline data of 4149 participants (45-75 years, 50% women) of the population-based Heinz Nixdorf Recall study. Serum 25-(OH)D was measured with the Roche Cobas assay. Quartiles (p25, p50, and p75) were calculated. Data were stratified by months, sex, and age. According to the recommendations of 'Dachverband Osteologie', Endocrine Society and National Institute of Health we used 25-(OH)D thresholds of 12, 20, and 30 ng/ml to estimate vitamin D deficiency...
April 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28414251/impact-of-metabolic-status-on-the-association-of-serum-vitamin-d-with-hypogonadism-and-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#3
Sun Gu Park, Jeong Kyun Yeo, Dae Yeon Cho, Min Gu Park
OBJECTIVE: The objective of this study is to investigate the impact of metabolic status on associations of serum vitamin D with hypogonadism and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). PATIENTS AND METHODS: A total of 612 men underwent physical examination, biochemical/hormonal blood testing, and transrectal prostate ultrasound. Moreover, the subjects filled out standard questionnaires for identification and grading of LUTS and hypogonadism symptoms...
April 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28413173/25-hydroxyvitamin-d-serum-level-in-hashimoto-s-thyroiditis-but-not-graves-disease-is-relatively-deficient
#4
Wencai Ke, Tiange Sun, Yanan Zhang, Leqi He, Qiang Wu, Jun Liu, Bingbing Zha
Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department...
April 11, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28407358/vitamin-d-related-genes-are-subjected-to-significant-de-novo-mutation-burdens-in-autism-spectrum-disorder
#5
Jinchen Li, Lin Wang, Ping Yu, Leisheng Shi, Kun Zhang, Zhong Sheng Sun, Kun Xia
Vitamin D deficiency is a putative environmental risk factor for autism spectrum disorder (ASD). Besides, de novo mutations (DNMs) play essential roles in ASD. However, it remains unclear whether vitamin D-related genes (VDRGs) carry a strong DNM burden. For the 943 reported VDRGs, we analyzed publicly-available DNMs from 4,327 ASD probands and 3,191 controls. We identified 126 and 44 loss-of-function or deleterious missense mutations in the probands and the controls, respectively, representing a significantly higher DNM burden (p = 1...
April 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28403225/association-of-vitamin-d-deficiency-season-of-the-year-and-latent-tuberculosis-infection-among-household-contacts
#6
María Elvira Balcells, Patricia García, Camila Tiznado, Luis Villarroel, Natalia Scioscia, Camila Carvajal, Francesca Zegna-Ratá, Mariluz Hernández, Paulina Meza, Luis F González, Carlos Peña, Rodrigo Naves
OBJECTIVES: Vitamin D (VD) enhances the immune response against Mycobacterium tuberculosis in vitro, and VD deficiency has been described in patients with active tuberculosis (TB). However, the role of hypovitaminosis D in the pathogenesis of early TB infection acquisition is unclear. We aimed to evaluate the association of VD deficiency, season of the year, and latent TB infection in household contacts (HHC), given that this is a potentially modifiable condition often related to nutritional deficiencies and lack of sun exposure...
2017: PloS One
https://www.readbyqxmd.com/read/28401345/vitamin-d-in-european-children-statement-from-the-european-academy-of-paediatrics-eap
#7
Zachi Grossman, Adamos Hadjipanayis, Tom Stiris, Stefano Del Torso, Jean-Christophe Mercier, Arunas Valiulis, Raanan Shamir
Vitamin D is synthesized in human skin upon sun exposure and is also a nutrient. It regulates calcium and phosphate metabolism and is essential for the maintenance of bone health. Vitamin D supplementation during infancy, in order to prevent rickets, is universally accepted. Many human cell types carry vitamin D receptor, this being a drive for conducting studies on the possible association between vitamin D status and other diseases. Studies have affirmed that a considerable number of healthy European children may be vitamin D deficient, especially in high-risk groups (darker pigmented skin, living in areas with reduced sun exposure and other disorders)...
April 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28394278/vitamin-d-deficiency-among-adults-with-history-of-pulmonary-tuberculosis-in-korea-based-on-a-nationwide-survey
#8
Mi Hyun Joo, Mi Ah Han, Sun Mi Park, Hwan Ho Shin
We investigated the prevalence of vitamin D deficiency among individuals who have a history of tuberculosis (TB) diagnosis in Korea. Using the 5th Korean National Health and Nutrition Examination Survey, we selected 805 individuals with a history of TB diagnosis and 16,049 controls without a history of TB. Vitamin D deficiency was defined as a 25(OH)D level less than 20 ng/mL. Vitamin D deficiency was revealed in 71.7% of the individuals with a history of TB diagnosis and in 72.1% of the controls. Vitamin D deficiency was more likely in women than in men, in people who engaged in other jobs or were unemployed than in people who engaged in skilled agricultural, forestry, and fishery jobs, and in people who walked 3-5 days per week than in people who walked 6-7 days per week...
April 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28387318/comparative-analysis-of-nutritional-guidelines-for-vitamin-d
#9
REVIEW
Roger Bouillon
Vitamin D is essential for calcium and bone homeostasis. Humans are largely dependent on UVB-radiation-induced photosynthesis of vitamin D, as few foods contain vitamin D. However, the same radiation that produces vitamin D is also carcinogenic, albeit with a long lag time, and causes DNA damage. In view of the increasing life expectancy, avoiding excessive sun exposure is prudent. Several groups of people have a shortfall between their requirements for vitamin D and their combined endogenous synthesis and intake from natural foods, and therefore need vitamin D supplementation...
April 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28386263/adaptive-immunity-is-the-key-to-the-understanding-of-autoimmune-and-paraneoplastic-inflammatory-central-nervous-system-disorders
#10
REVIEW
Robert Weissert
There are common aspects and mechanisms between different types of autoimmune diseases such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSDs), and autoimmune encephalitis (AE) as well as paraneoplastic inflammatory disorders of the central nervous system. To our present knowledge, depending on the disease, T and B cells as well as antibodies contribute to various aspects of the pathogenesis. Possibly the events leading to the breaking of tolerance between the different diseases are of great similarity and so far, only partially understood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28382112/the-role-of-vitamin-d-in-maintaining-bone-health-in-older-people
#11
REVIEW
Thomas R Hill, Terry J Aspray
This review summarises aspects of vitamin D metabolism, the consequences of vitamin D deficiency, and the impact of vitamin D supplementation on musculoskeletal health in older age. With age, changes in vitamin D exposure, cutaneous vitamin D synthesis and behavioural factors (including physical activity, diet and sun exposure) are compounded by changes in calcium and vitamin D pathophysiology with altered calcium absorption, decreased 25-OH vitamin D [25(OH)D] hydroxylation, lower renal fractional calcium reabsorption and a rise in parathyroid hormone...
April 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28367447/association-between-parathyroid-hormone-25-oh-vitamin-d-and-chronic-kidney-disease-a-population-based-study
#12
Wei-Hao Wang, Li-Wei Chen, Chin-Chan Lee, Chiao-Yin Sun, Yu-Chiau Shyu, Heng-Rong Hsu, Rong-Nang Chien, I-Wen Wu
Identification of the accurate risk factor for CKD remains mandatory to combat the high prevalence of diseases. Growing evidence suggests the association of serum vitamin D with diverse health conditions. However, the relationship between vitamin D, intact parathyroid hormone (PTH), and calcium-phosphate metabolism and development of CKD remains controversial. We conduct this cross-sectional observational study to investigate the association between serum 25 (OH) vitamin D, intact PTH, and calcium and phosphate levels with eGFR and albuminuria, as a surrogate marker of CKD, in a community population...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28356731/co-delivery-nanoparticles-with-characteristics-of-intracellular-precision-release-drugs-for-overcoming-multidrug-resistance
#13
DanDan Zhang, Yan Yan Kong, Jia Hui Sun, Shao Jie Huo, Min Zhou, Yi Ling Gui, Xu Mu, Huan Chen, Shu Qin Yu, Qian Xu
Combination chemotherapy in clinical practice has been generally accepted as a feasible strategy for overcoming multidrug resistance (MDR). Here, we designed and successfully prepared a co-delivery system named S-D1@L-D2 NPs, where denoted some smaller nanoparticles (NPs) carrying a drug doxorubicin (DOX) were loaded into a larger NP containing another drug (vincristine [VCR]) via water-in-oil-in-water double-emulsion solvent diffusion-evaporation method. Chitosan-alginate nanoparticles carrying DOX (CS-ALG-DOX NPs) with a smaller diameter of about 20 nm formed S-D1 NPs; vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-modified poly(lactic-co-glycolic acid) nanoparticles carrying VCR (TPGS-PLGA-VCR NPs) with a larger diameter of about 200 nm constituted L-D2 NPs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28345527/prevalence-and-factors-promoting-the-occurrence-of-vitamin-d-deficiency-in-the-elderly
#14
Magdalena Wyskida, Katarzyna Wieczorowska-Tobis, Jerzy Chudek
Vitamin D deficiency affects a large part of the population of elderly people, especially women, who live in moderate climate countries due to a reduced amount of vitamin D in the diet (small sea fish consumption) and reduced content of 7-dehydrocholesterol, which causes decreased skin synthesis. The lowest seasonal concentration of 25(OH)D3 is usually observed during winter and spring. Sun exposure influences 25(OH)D3 concentration more strongly in men than in women. Sociodemographic factors that increase the risk of vitamin D deficiency in the elderly include poor environmental conditions, low economic status, lower educational level, drug exposure (smoking), reduced physical activity, overall poor health and obesity, which causes reduced skin exposure to sunlight...
March 13, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28331054/ambient-uvb-dose-and-sun-enjoyment-are-important-predictors-of-vitamin-d-status-in-an-older-population
#15
Fiona O'Sullivan, Eamon Laird, Dervla Kelly, Jos van Geffen, Michiel van Weele, Helene McNulty, Leane Hoey, Martin Healy, Kevin McCarroll, Conal Cunningham, Miriam Casey, Mary Ward, J J Strain, Anne M Molloy, Lina Zgaga
Background: UVB-induced skin synthesis is considered the key source of vitamin D, yet exposure to UVB is poorly accounted for in epidemiological studies.Objectives: The aim of this study was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] concentration with accurately measured ambient UVB dose, sun enjoyment, supplements, and other factors.Methods: An all-Irish cohort of community-dwelling participants aged >60 y [median age: 73; 67% female; median 25(OH)D: 54.5 nmol/L] was used. Participants from this large, cross-sectional study completed a questionnaire to provide information on demographic factors and lifestyle (including supplement use and sun enjoyment)...
March 22, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28329672/vitamin-d-and-skin-aging
#16
Merel A Hamer, Raymond Noordam, Luba M Pardo, Diana Van Heemst, David A Gunn, Tamar Nijsten
BackgroundThe relationship between 25-hydroxyvitamin D and different phenotypes of skin aging (e.g., wrinkles, pigmented spots, telangiectasia, perceived age) is unclear. We investigated the association between vitamin D levels and skin aging phenotypes in middle-aged participants from the Rotterdam Study (RS) and Leiden Longevity Study (LLS).MethodsStandardized facial photographs were taken of North-European participants from the RS (N=3,831; 58.2% female, median age 66.5) and the LLS (N=661; 50.5% female, median age 63...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329635/compliance-with-indoor-tanning-laws-for-minors-among-salons-and-business-in-the-united-states
#17
Courtney Choy, Brenda Cartmel, Rachel Clare, Leah M Ferrucci
Indoor tanning is an established risk factor for skin cancer, yet indoor tanning is quite common among adolescents. Laws exists in some states to limit access to indoor tanning by minors, but there is limited research on industry compliance with these laws.We conducted a telephone survey with a random sample of businesses (n=412) offering indoor tanning in the 14 states with indoor tanning bans for minors as of May 2015. Female research assistants posing as minors conducted telephone interviews with employees using a standardized script...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329465/youtube-as-a-source-of-health-information-analysis-of-sun-protection-and-skin-cancer-prevention-related-issues
#18
Linda Ruppert, Brian Køster, Anna Maria Siegert, Christian Cop, Lindsay Boyers, Chante Karimkhani, Helena Winston, Jessica Mounessa, Robert P Dellavalle, Daphne Reinau, Thomas Diepgen, Christian Surber
Although social media ubiquitously supplementstraditional information sources such as newspapers,magazines, radio, and television, investigation of onlinehealth information related to sun protection and skincancer prevention has been scarce and largely limitedto English language sources. Using the search terms"sun protection," "sunscreen," "skin cancer prevention,"tanning bed" and "vitamin D," we investigated 281YouTube videos presented in 6 languages: English,German, French, Spanish, Swedish, and Danish. Foreach video, we used a four-sectioned checklist toassess general information, popularity, expert drivenmeasures, and heuristic driven measures...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28326301/association-of-serum-25-hydroxy-vitamin-d-concentration-and-arterial-stiffness-among-korean-adults-in-single-center
#19
Jung Hae Lee, Heuy Sun Suh
BACKGROUND: There are growing concerns about the role of vitamin D deficiency in cardiovascular diseases. Therefore, we investigated the correlation between serum 25-hydroxy-vitamin D (25[OH]D) and arterial stiffness among Korean adults. METHODS: We retrospectively reviewed the medical charts of 302 people (115 women and 187 men) who visited a tertiary hospital from January 2015 to December 2016. Serum 25(OH)D was measured using the radioimmunoassay technique, and brachial-ankle pulse wave velocity (baPWV) was measured using an automatic wave analyzer...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28322879/the-association-between-beliefs-about-vitamin-d-and-skin-cancer-risk-related-behaviors
#20
Dawn M Holman, Zahava Berkowitz, Gery P Guy, Natasha Buchanan Lunsford, Elliot J Coups
Major health organizations recommend obtaining most of one's vitamin D through dietary sources rather than from sun exposure, given the link between sun exposure and increased skin cancer risk. The purpose of this study is to examine the association between beliefs about vitamin D and skin cancer risk-related behaviors, a topic on which research is limited. We analyzed cross-sectional online survey data collected in the summer of 2015 from 4127U.S. adults aged 18years and older. Overall, 19.7% of adults believed that sun protection would put them at risk of not getting enough vitamin D...
March 18, 2017: Preventive Medicine
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