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https://www.readbyqxmd.com/read/29677591/lifestyle-factors-and-multiple-sclerosis-a-population-based-incident-case-control-study
#1
Ibrahim Abdollahpour, Saharnaz Nedjat, Mohammad Ali Mansournia, Mohammad Ali Sahraian, Ingrid van der Mei
OBJECTIVE: Although low sun exposure, low vitamin D, and smoking are established risk factor of multiple sclerosis (MS), there is less evidence on the role of the other lifestyle factors. We examined the association of sun exposure, physical activity, drug abuse, and alcohol intake with MS. MATERIALS AND METHODS: This was population-based incident case-control study in Iran with 547 incident cases and 1057 general population controls (7/8/2013-17/2/2015). Logistic regression was used to analyse the data...
March 31, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29673142/meeting-vitamin-d-requirements-in-white-caucasians-at-uk-latitudes-providing-a-choice
#2
Ann R Webb, Andreas Kazantzidis, Richard C Kift, Mark D Farrar, Jack Wilkinson, Lesley E Rhodes
The body gains vitamin D through both oral intake (diet/supplementation) and synthesis in skin upon exposure to ultraviolet radiation (UVR). Sun exposure is the major source for most people even though sun exposure is complex and limited by climate and culture. We aimed to quantify the sun exposure required to meet vitamin D targets year-round and determine whether this can be safely achieved in a simply defined manner in the UK as an alternative to increasing vitamin D oral intake. Data from observation (sun exposure, diet, and vitamin D status) and UVR intervention studies performed with white Caucasian adults were combined with modeled all-weather UVR climatology...
April 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29662333/the-prevalence-of-hypovitaminosis-d-and-its-associated-risk-factors-among-women-of-reproductive-age-in-saudi-arabia-a-systematic-review-and-meta-analysis
#3
REVIEW
Riyadh A Alzaheb
Vitamin D deficiency is currently a worldwide epidemic. Middle Eastern countries, including Saudi Arabia, have high vitamin D deficiency prevalence, most prominently among women, despite their plentiful year-round sunshine. Previous research investigating vitamin D status among Saudi women of reproductive age (15-49 years) is scarce, and no study has used a nationally representative sample, so this review quantified overall hypovitaminosis D prevalence among women in Saudi Arabia and explored the associated risk factors...
2018: Clinical Medicine Insights. Women's Health
https://www.readbyqxmd.com/read/29662044/vitamin-d-deficiency-prevalence-and-predictors-in-early-pregnancy-among-arab-women
#4
Sara Al-Musharaf, Mona A Fouda, Iqbal Z Turkestani, Abdulrahman Al-Ajlan, Shaun Sabico, Abdullah M Alnaami, Kaiser Wani, Syed Danish Hussain, Buthaynah Alraqebah, Amal Al-Serehi, Naemah M Alshingetti, Nasser Al-Daghri, Philip G McTernan, Sunil J Wimalawansa, Ponnusamy Saravanan
Data regarding the prevalence and predictors of vitamin D deficiency during early pregnancy are limited. This study aims to fill this gap. A total of 578 Saudi women in their 1st trimester of pregnancy were recruited between January 2014 and December 2015 from three tertiary care antenatal clinics in Riyadh, Saudi Arabia. Information collected includes socio-economic, anthropometric, and biochemical data, including serum vitamin D (25(OH)D) levels, intake of calcium and vitamin D, physical activity, and sun exposure indices...
April 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29658832/the-associations-between-hypovitaminosis-d-higher-pth-levels-with-bone-mineral-densities-and-risk-of-the-10-year-probability-of-major-osteoporotic-fractures-in-chinese-patients-with-t2dm
#5
Xiao-Feng Wang, Jing-Jia Yu, Xiao-Jing Wang, Yi-Xuan Jing, Li-Hao Sun, Bei Tao, Wei-Qing Wang, Guang Ning, Jian-Min Liu, Hong-Yan Zhao
OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study of 785 patients. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of 25-hydroxyvitamin D (25(OH)D) and intact PTH were also quantified...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29657025/physical-fitness-adiposity-and-diets-as-surrogate-measures-of-bone-health-in-schoolchildren-a-biochemical-and-cross-sectional-survey-analysis
#6
Ahmad H Alghadir, Sami A Gabr, Ashraf A Rizk
This study aimed to investigate the associations between adiposity, muscular fitness (MF), diet, sun exposure, and physical activity profiles as surrogate measures with bone health status in a sample of schoolchildren aged 8-18 yr old. A total of 250 Egyptian schoolchildren aged 8-18 yr were randomly invited to participate in these cross-sectional survey analyses. Calcaneal broadband ultrasound attenuation (c-BUA), bone mineral density (BMD), and bone formation markers (total calcium, serum bone alkaline phosphatase, and osteocalcin) were measured as markers of bone health...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29649273/do-all-infants-need-vitamin-d-supplementation
#7
Ane Cristina Fayão Almeida, Francisco José Albuquerque de Paula, Jacqueline Pontes Monteiro, Carlos Alberto Nogueira-de-Almeida, Luiz Antonio Del Ciampo, Davi Casale Aragon, Ivan Savioli Ferraz
A high prevalence of vitamin D deficiency (VDD) in children has been observed worldwide, but there are few studies on the nutritional status of vitamin D (VD) in healthy infants. The main cause of deficiency in healthy children is breastfeeding without supplementation and lack or insufficiency of sun exposure. The aims of this study were to determine serum concentrations of 25(OH)D and verify its association with parathyroid hormone (PTH) concentrations and use of VD supplementation in healthy infants aged ≥ 6 to ≤ 24 months attended at two Primary Health Care Units in Ribeirão Preto city, São Paulo, Brazil...
2018: PloS One
https://www.readbyqxmd.com/read/29642423/colour-counts-sunlight-and-skin-type-as-drivers-of-vitamin-d-deficiency-at-uk-latitudes
#8
Ann R Webb, Andreas Kazantzidis, Richard C Kift, Mark D Farrar, Jack Wilkinson, Lesley E Rhodes
Sunlight exposure, with resulting cutaneous synthesis, is a major source of vitamin D for many, while dietary intake is low in modern diets. The constitutive pigment in skin determines skin type, observed as white, brown, or black skin. The melanin pigment absorbs ultraviolet radiation (UVR) and protects underlying skin from damage caused by UVR. It also reduces the UVR available for vitamin D synthesis in the skin. It has been shown that the white-skinned population of the UK are able to meet their vitamin D needs with short, daily lunchtime exposures to sunlight...
April 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29629026/effect-of-vitamin-c-on-azoxymethane-aom-dextran-sulfate-sodium-dss-induced-colitis-associated-early-colon-cancer-in-mice
#9
Hee-Jin Jeon, Yiseul Yeom, Yoo-Sun Kim, Eunju Kim, Jae-Ho Shin, Pu Reum Seok, Moon Jea Woo, Yuri Kim
BACKGROUND/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model. MATERIALS/METHODS: Male BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29620547/vitamin-d-deficiency-in-sickle-cell-disease-patients-in-the-eastern-province-of-saudi-arabia
#10
Ali AlJama, Mohammed AlKhalifah, Ibrahim Abdulla Al-Dabbous, Ghada Alqudaihi
BACKGROUND: Vitamin D deficiency (VDD) is a major global health problem. In sickle cell disease (SCD), VDD is highly prevalent, reaching up to 96% of populations. VDD may contribute to many of the complications of SCD. OBJECTIVE: Estimate the 25-hydroxyvitamin D [25(OH)D] level and the frequency of VDD and insufficiency among among SCD patients by age group and disease status. DESIGN: Analytical cross-sectional. SETTING: Ministry of Health (MOH) secondary care hospital...
March 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29619453/effect-of-solar-ultraviolet-radiation-exposure-on-serum-25-oh-d-concentration-a-pilot-randomised-controlled-trial
#11
Shanchita R Khan, David C Whiteman, Michael G Kimlin, Monika Janda, Michael W Clarke, Robyn M Lucas, Rachel E Neale
Sunlight generates vitamin D, but there are scant human data from randomised trials on which to base health policy advice about how much sun exposure is necessary to change 25(OH)D concentrations. The purpose of the study was to evaluate the feasibility of using solar ultraviolet (UV) radiation exposure to generate a change in 25(OH)D concentration in a randomised controlled trial (RCT). The intervention tested in this RCT was supervised exposure to one standard erythemal dose (SED; 100 J m-2) of solar UV radiation three days per week for three weeks with approximately 35% of the body surface area not covered by clothing...
April 5, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29618203/rational-design-of-multifunctional-polymeric-nanoparticles-based-on-poly-l-histidine-and-d-%C3%AE-vitamin-e-succinate-for-reversing-tumor-multidrug-resistance
#12
Zhen Li, Qixian Chen, Yan Qi, Zhihao Liu, Tangna Hao, Xiaoxin Sun, Mingxi Qiao, Xiaodong Ma, Ting Xu, Xiuli Zhao, Chunrong Yang, Dawei Chen
A multifunctional nanoparticulate system composed of methoxy poly(ethylene glycol)-poly(L-histidine)-d-α-Vitamin E succinate (MPEG-PLH-VES) copolymers for encapsulation of doxorubicin (DOX) was elaborated with the aim of circumventing the multidrug resistance (MDR) in breast cancer treatment. The MPEG-PLH-VES nanoparticles (NPs) were subsequently functionalized with biotin motif for targeted drug delivery. The MPEG-PLH-VES copolymer exert no obvious effect on the P-gp expression level of MCF-7/ADR but exhibited a significant influence on the loss of mitochondrial membrane potential, the reduction of intracellular ATP level and the inhibition of P-gp ATPase activity of MCF-7/ADR cells...
April 4, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29614873/vitamin-d-status-among-young-children-aged-6-to-23-months-from-4-different-ethnic-groups-in-yunnan-china
#13
Yanhong Li, Yan Li, Xian Zhang, Lin Zhao, Liqin Chen, Haisong Sun
OBJECTIVES: To determine the prevalence of vitamin D deficiency in 6- to 23-month-old children from 4 different ethnic groups, Han, Lisu, Hani, and Bai, in Yunnan Province of China. METHODS: A large cohort of 938 young children aged 6 to 23 months who were living in Yunnan, China (23°28'-27°52' N), were selected and recruited in this study. Venous-blood sampling was conducted in all the participants, and serum 25-hydroxyvitamin D [25(OH)D] levels were measured...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29606375/the-roles-of-vitamin-d-and-cutaneous-vitamin-d-production-in-human-evolution-and-health
#14
REVIEW
Nina G Jablonski, George Chaplin
Most of the vitamin D necessary for the maintenance of human health and successful reproduction is made in the skin under the influence of a narrow portion of the electromagnetic spectrum emitted from the sun, namely ultraviolet B radiation (UVB). During the course of human evolution, skin pigmentation has evolved to afford protection against high levels of UVR while still permitting cutaneous production of vitamin D. Similar pigmentation phenotypes evolved repeatedly as the result of independent genetic events when isolated human populations dispersed into habitats of extremely low or high UVB...
March 29, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29599679/seasonal-variation-of-asthma-control-lung-function-tests-and-allergic-inflammation-in-relation-to-vitamin-d-levels-a-prospective-annual-study
#15
Sehra Birgül Batmaz, Tuğba Arıkoğlu, Lülüfer Tamer, Gülçin Eskandari, Semanur Kuyucu
Introduction: There are scarce data about the role of vitamin D (vitD) in asthma control related to seasons and other confounders. Aim: To investigate the seasonal relationship between vitD levels and asthma control, lung function tests (LFTs) and cytokines during a 1-year period, among 7-17-year-old asthmatic children. Material and methods: Thirty patients with asthma with house dust mite monosensitization were evaluated 3 monthly about the previous month's health and vitD related lifestyle factors and asthma control test (ACT), spirometry and bronchial provocation test for a year...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29595633/vitamin-intake-and-pancreatic-cancer-risk-reduction-a-meta-analysis-of-observational-studies
#16
REVIEW
Ying Liu, Xiaojie Wang, Xuejia Sun, Shengnan Lu, Shi Liu
BACKGROUND: The relationship between vitamin intake and pancreatic cancer (PC) risk is disputed. We aimed to investigate the association between vitamin intake and the risk of PC via meta-analysis. METHODS: We conducted a meta-analysis of studies concerning vitamin intake and the risk of PC from EMBASE, MEDLINE, and Cochrane Library. The search yielded 25 correlative studies including 1,214,995 individuals. The relative risks (RR) were examined by a random-effect model or fixed-effect model...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29576253/nutritional-management-of-cow-s-milk-allergy-in-children-an-update
#17
C Dupont, J-P Chouraqui, A Linglart, A Bocquet, D Darmaun, F Feillet, M-L Frelut, J-P Girardet, R Hankard, J-C Rozé, U Simeoni, A Briend
Cow's milk is one of the most common foods responsible for allergic reactions in children. Cow's milk allergy (CMA) involves immunoglobulin E (IgE)- and non-IgE-mediated reactions, the latter being both variable and nonspecific. Guidelines thus emphasize the need for physicians to recognize the specific syndromes of CMA and to respect strict diagnostic modalities. Whatever the clinical pattern of CMA, the mainstay of treatment is the elimination from the diet of cow's milk proteins. The challenge is that both the disease and the elimination diet may result in insufficient height and weight gain and bone mineralization...
March 22, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29569569/vitamin-d-in-adults-update-on-testing-and-supplementation
#18
Cédric Annweiler, Erick Legrand, Jean-Claude Souberbielle
Hypovitaminosis D, a frequent condition in adults, is accompanied by adverse skeletal and non-skeletal events. The objective of the present article was to propose an update on the indications and use of vitamin D testing and supplementation in adults. Among healthy middle-aged adults, the serum 25-hydroxyvitamin D (25(OH)D) target concentration is 50 nmol/L. Natural intakes (sun exposure and diet) are sufficient, and there is no indication for systematic blood test or supplementation. In middle-aged adults who are either sick or dependent or frail, natural intakes are generally insufficient but should be encouraged...
March 1, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29561174/effect-of-vitamin-d-treatments-on-plasma-metabolism-and-immune-parameters-of-healthy-dairy-cows
#19
Yuan Yue, Lone Hymøller, Søren Krogh Jensen, Charlotte Lauridsen
The objective of this study was to investigate the possible beneficial effect of vitamin D repletion on certain immune parameters of vitamin D insufficient dairy cows. Twenty dairy cows in late lactation were treated daily with vitamin D in five different ways: sunlight exposure (SUN), D2 supplementation combined with sunlight exposure (D2SUN), D2 supplementation (D2), D3 supplementation (D3), and D2 and D3 supplementation combined (D2D3). The cows had very low vitamin D levels at d 0 because of the vitamin D deprivation before the study...
March 21, 2018: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/29560132/associations-between-vdr-gene-polymorphisms-and-colorectal-cancer-susceptibility-an-updated-meta-analysis-based-on-39-case-control-studies
#20
Zhipeng Pan, Mengya Chen, Xingxing Hu, Hua Wang, Jiajia Yang, Congjun Zhang, Faming Pan, Guoping Sun
Background: Recent studies have reported the associations between vitamin D receptor ( VDR ) polymorphisms and colorectal cancer (CRC), but the results were not always consistent. This meta-analysis aims to evaluate whether VDR polymorphisms are associated with CRC susceptibility. Materials And Methods: Studies on the associations between VDR polymorphisms and CRC were retrieved from the Web of Science, PubMed, the Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI) and Wanfang (Chinese) databases...
February 27, 2018: Oncotarget
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