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https://www.readbyqxmd.com/read/28822355/baseline-assessment-of-25-hydroxyvitamin-d-assay-performance-a-vitamin-d-standardization-program-vdsp-interlaboratory-comparison-study
#1
Stephen Wise, Karen Phinney, Susan Tai, Johanna Camara, Gary Myers, Ramon Durazo-Arvizu, Lu Tian, Andrew Hoofnagle, Lorin Bachmann, Ian Young, Juanita Pettit, Grahame Caldwell, Andrew Liu, Stephen Brooks, Kurtis Sarafin, Michael Thamm, Gert Mensink, Markus Busch, Martina Rabenberg, Kevin Cashman, Mairead Kiely, Michael Kinsella, Karen Galvin, Joy Zhang, Kyungwon Oh, Sun-Wha Lee, Chae Jung, Lorna Cox, Gail Goldberg, Kate Guberg, Ann Prentice, Graham Carter, Julia Jones, Patsy Brannon, Robyn Lucas, Peter Crump, Etienne Cavalier, Joyce Merkel, Joseph Betz, Christopher Sempos
The Vitamin D Standardization Program (VDSP) coordinated an interlaboratory study to assess the comparability of measurements of total 25-hydroxyvitamin D [25(OH)D] in human serum, which is the primary marker of vitamin D status. A set of 50 individual donor samples were analyzed by 15 different laboratories representing national nutrition surveys, assay manufacturers, and clinical and/or research laboratories to provide results for total 25(OH)D using both immunoassays (IAs) and LC tandem MS (MS/MS). The results were evaluated relative to bias compared with the target values assigned based on a combination of measurements at Ghent University (Belgium) and the U...
August 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28822224/is-it-necessary-for-all-samples-to-quantify-25ohd2-and-25ohd3-using-lc-ms-ms-in-clinical-practice
#2
Songlin Yu, Ruiping Zhang, Weiyan Zhou, Xinqi Cheng, Qian Cheng, Liangyu Xia, Shaowei Xie, Yicong Yin, Dandan Sun, Wei Su, Ling Qiu
BACKGROUND: The demand for vitamin D testing is increasing in China. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) immunoassay is specific and accurate but requires expensive equipment, experienced operators, and complicated pretreatment of serum. Automated immunoassays are simple and convenient but only determine total 25-hydroxyvitamin D (25OHD). The objective of this study was to quantify 25OHD2 and 25OHD3 in patients to assist clinical physicians and laboratory directors in choosing the most appropriate method to determine 25OHD...
August 19, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28820448/vitamin-d-status-of-residents-in-taiyuan-china-and-influencing-factors
#3
Xiaoning Yan, Jasmine S Thomson, Ruibao Zhao, Ruifang Zhu, Zhaolin Wang, Na Zhang, Jane Coad
High prevalence of vitamin D deficiency has been reported worldwide. Residents of Taiyuan, China, were predicted to be at high risk of vitamin D deficiency due to its high latitude, heavy air pollution, and cultural sun avoidance. This study investigated the vitamin D status of office workers, and explored the potential determinants of capillary 25-hydroxyvitamin D (25(OH)D) concentration as well as the relationship between 25(OH)D and metabolic syndrome. Two hundred participants, aged 20 to 80 years, were recruited...
August 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28815553/osteoporosis-in-erythropoietic-protoporphyria-patients
#4
M Biewenga, R H S Matawlie, E C H Friesema, H Koole-Lesuis, M Langeveld, J H P Wilson, J G Langendonk
BACKGROUND: Erythropoietic protoporphyria is a rare metabolic disease with painful photosensitivity due to protoporphyrin IX accumulation, resulting in lifelong light avoidance behaviour. OBJECTIVES: The aim of this study was to evaluate bone mineral density and known osteoporosis risk factors in erythropoietic protoporphyria patients. METHODS: In this cross-sectional study all erythropoietic protoporphyria patients attending the Erasmus MC outpatient clinic that had undergone bone mineral density measurements were included...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28813022/impact-of-orientation-on-the-vitamin-d-weighted-exposure-of-a-human-in-an-urban-environment
#5
Michael Schrempf, Nadine Thuns, Kezia Lange, Gunther Seckmeyer
The vitamin D₃-weighted UV exposure of a human with vertical posture was calculated for urban locations to investigate the impact of orientation and obstructions on the exposure. Human exposure was calculated by using the 3D geometry of a human and integrating the radiance, i.e., the radiant energy from the direct solar beam and the diffuse sky radiation from different incident and azimuth angles. Obstructions of the sky are derived from hemispherical images, which are recorded by a digital camera with a fisheye lens...
August 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28811787/association-between-vitamin-d-deficiency-and-breast-cancer
#6
Noureen Shaukat, Farhat Jaleel, Foad Ali Moosa, Naeem Akhter Qureshi
OBJECTIVE: To determine the association between vitamin D deficiency and breast cancer. METHODS: This case control study included 94 female patients aged 20-75 years of any marital status and parity. Newly diagnosed 42 breast cancer patients who presented to surgical OPD of Dow University Hospital from Jan 2016 to June 2016 were included into the study as "cases" after informed consent. Age-matched 52 females who presented to OPD for complain other than breast pathology were included as the "control group"...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28803880/vitamin-d-and-symptoms-of-depression-in-overweight-or-obese-adults-a-cross-sectional-study-and-randomized-placebo-controlled-trial
#7
Aya Mousa, Negar Naderpoor, Maximilian P J de Courten, Barbora de Courten
Recent evidence suggests that vitamin D deficiency may contribute to increased risk of depression. However, previous studies are limited by variability in participant characteristics including vitamin D deficiency status and presence of existing diseases, use of low doses of vitamin D supplementation for short durations, and use of co-interventions or psychotropic drugs. We examined whether 25-hydroxyvitamin D (25(OH)D) concentrations were associated with symptoms of depression, as well as whether vitamin D supplementation reduced symptoms of depression in overweight or obese and vitamin D-deficient, but otherwise healthy adults...
August 10, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28803689/sun-exposure-influences-the-prognostic-power-of-components-of-mineral-metabolism-in-patients-with-coronary-artery-disease
#8
A Aceña, J A Franco-Peláez, C Gutierrez-Landaluce, A M Pello, C Cristóbal, N Tarín, A Huelmos, R Carda, M L Martín-Mariscal, J Alonso, E González-Parra, M L González-Casaus, Ó Lorenzo, L López Bescos, J Egido, J Tuñón
BACKGROUND AND AIM: Calcidiol (vitamin D metabolite) plasma levels vary with sun exposure (SE). However, it is not known if SE influences its prognostic ability. We have studied the effect of SE on plasma levels of the components of mineral metabolism (calcidiol, fibroblast growth factor-23 [FGF-23], parathormone [PTH], and phosphate [P]) and on their prognostic value in patients with coronary artery disease (CAD). METHODS AND RESULTS: We studied prospectively 704 patients with stable CAD...
June 15, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28797319/baseline-assessment-of-25-hydroxyvitamin-d-reference-material-and-proficiency-testing-external-quality-assurance-material-commutability-a-vitamin-d-standardization-program-study
#9
Karen Phinney, Christopher Sempos, Susan Tai, Johanna Camara, Stephen Wise, John Eckfeldt, Andrew Hoofnagle, Graham Carter, Julia Jones, Gary Myers, Ramon Durazo-Arvizu, W Greg Miller, Lorin Bachmann, Ian Young, Juanita Pettit, Andrew Liu, Stephen Brooks, Kurtis Sarafin, Michael Thamm, Gert Mensink, Markus Busch, Martina Rabenberg, Kevin Cashman, Mairead Kiely, Karen Galvin, Joy Zhang, Michael Kinsella, Kyungwon Oh, Sun-Wha Lee, Chae Jung, Lorna Cox, Gail Goldberg, Kate Guberg, Sarah Meadows, Ann Prentice, Lu Tian, Patsy Brannon, Robyn Lucas, Peter Crump, Etienne Cavalier, Joyce Merkel, Joseph Betz, Grahame Caldwell
The Vitamin D Standardization Program (VDSP) coordinated a study in 2012 to assess the commutability of reference materials and proficiency testing/external quality assurance materials for total 25-hydroxyvitamin D [25(OH)D] in human serum, the primary indicator of vitamin D status. A set of 50 single-donor serum samples as well as 17 reference and proficiency testing/external quality assessment materials were analyzed by participating laboratories that used either immunoassay or LC-MS methods for total 25(OH)D...
August 10, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28776491/an-analysis-of-factors-associated-with-25-hydroxyvitamin-d-levels-in-white-and-non-white-canadians
#10
Stephen Brooks, Linda Greene-Finestone, Susan Whiting, Vitali Fioletov, Patrick Laffey, Nicholas Petronella
Vitamin D status was assessed in 19–79 year old whites (8351 participants of European ancestry) and non-whites (1840 participants encompassing all other ancestries) from cycles 1 to 3 (years 2007–2013) of the Canadian Health Measures Survey. Status was assessed using the U.S. Institute of Medicine (IOM) 25-hydroxyvitamin D [25(OH)D] cut point values of 30 and 40 nmol/L. Overall, median 25(OH)D concentrations were significantly higher in whites [58.9 (28.6, 100.1) nmol/L; 5th and 95th percentile] compared with non-whites [43...
August 4, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28761286/house-dust-mite-sensitization-is-inversely-associated-with-plasma-25-hydroxyvitamin-d3-levels-in-patients-with-severe-atopic-dermatitis
#11
Yong Hyun Jang, Hyun Bo Sim, Sun Young Moon, Weon Ju Lee, Seok-Jong Lee, Meiling Jin, Sang-Hyun Kim, Do Won Kim
BACKGROUND: The relationship between atopic dermatitis (AD) and low vitamin D levels has been studied. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. However, the effect of vitamin D on house dust mite (HDM) sensitization in patients with AD has not been established. OBJECTIVE: We investigated the association between vitamin D levels and HDM sensitization according to AD severity...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28759618/prevalence-and-predictors-of-hypovitaminosis-d-among-the-elderly-in-subtropical-region
#12
Chi-Hsien Huang, Yu-Tung Anton Huang, Yu-Cheng Lai, Cheuk-Kwan Sun
The prevalence of low vitamin D status in the elderly population of subtropical area and the potential risk/protective factors have not been addressed. This cross-sectional questionnaire-based study, which collected demographic/anthropometric data and information on diet habit and sun exposure, recruited 170 subjects with mean age 70.9±5.6 in rural areas of southern Taiwan. Serum 25-OH vitamin D, calcium, and intact parathyroid hormone were also measured. Using cut-off level of 30 ng/mL, subjects were divided into low (n = 95) and normal (n = 75) serum vitamin D groups...
2017: PloS One
https://www.readbyqxmd.com/read/28754822/epigenetic-research-in-multiple-sclerosis-progress-challenges-and-opportunities
#13
Galina Zheleznyakova, Eliane Piket, Francesco Marabita, Majid Pahlevan Kakhki, Ewoud Ewing, Sabrina Ruhrmann, Maria Needhamsen, Maja Jagodic, Lara Kular
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. MS likely results from a complex interplay between predisposing causal gene variants (the strongest influence coming from HLA class II locus) and environmental risk factors such as smoking, infectious mononucleosis and lack of sun exposure/vitamin D. However, little is known about the mechanisms underlying MS development and progression. Moreover, the clinical heterogeneity and variable response to treatment represent additional challenges to a comprehensive understanding and efficient treatment of disease...
July 28, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28735597/correlates-and-family-aggregation-of-vitamin-d-concentrations-in-school-aged-children-and-their-parents-in-nine-mesoamerican-countries
#14
Sonia L Robinson, Manuel Ramirez-Zea, Ana Victoria Roman, Eduardo Villamor
OBJECTIVE: To determine the associations of sociodemographic characteristics, diet and outdoor activity as an indicator of sun exposure with serum 25-hydroxyvitamin D (25(OH)D) concentrations in children and their parents from Mesoamerica. We also quantified family aggregation of serum 25(OH)D. DESIGN: Cross-sectional study. Serum 25(OH)D concentrations were quantified using immunoassay. We compared the distribution of 25(OH)D concentrations in adults and children by levels of each correlate with the use of linear regression...
July 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28718005/sunscreens-block-cutaneous-vitamin-d-production-with-only-a-minimal-effect-on-circulating-25-hydroxyvitamin-d
#15
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F Nikkels
A 50+ SPF sunscreen decreased significantly cutaneous vitamin D production following a single narrow-band (nb)UVB exposure, independently from the body surface area exposed. In contrast, the circulating 25(OH)D3 levels were only minimally affected. It is probable that another endogenous source of precursors is selected when skin-originated precursors are lacking. PURPOSE: Sunscreen use, highly advocated for preventing cutaneous carcinogenesis, is potentially leading to an aggravation of vitamin D deficiency with its consequences on bone health...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28700743/polymorphisms-in-the-vitamin-d-receptor-gene-are-associated-with-reduced-rate-of-sputum-culture-conversion-in-multidrug-resistant-tuberculosis-patients-in-south-africa
#16
Matthew J Magee, Yan V Sun, James C M Brust, N Sarita Shah, Yuming Ning, Salim Allana, Angela Campbell, Qin Hui, Koleka Mlisana, Pravi Moodley, Neel R Gandhi
BACKGROUND: Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin. Deficiency of 25-hydroxyvitamin D and single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene may increase the risk of TB disease and decrease culture conversion rates in drug susceptible TB. Whether these VDR SNPs are found in African populations or impact multidrug-resistant (MDR) TB treatment has not been established...
2017: PloS One
https://www.readbyqxmd.com/read/28690638/fat-soluble-vitamin-deficiency-in-pediatric-patients-with-biliary-atresia
#17
Rui Dong, Song Sun, Xiao-Zhou Liu, Zhen Shen, Gong Chen, Shan Zheng
OBJECTIVE: To analyze the levels of fat-soluble vitamins (FSVs) in pediatric patients with biliary atresia (BA) before and after the Kasai procedure. METHODS: Pediatric patients with obstructive jaundice were enrolled in this study. The FSV levels and liver function before, 2 weeks after, and 1, 3, and 6 months after the Kasai procedure were measured. RESULTS: FSV deficiency was more obvious in patients with BA than in patients with other cholestatic liver diseases, especially vitamin D deficiency...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28678758/meta-analysis-of-the-correlation-between-vitamin-d-and-lung-cancer-risk-and-outcomes
#18
Jian Liu, Yongquan Dong, Chao Lu, Yina Wang, Ling Peng, Mengjie Jiang, Yemin Tang, Qiong Zhao
In this meta-analysis, we analyzed the association between vitamin D levels and lung carcinoma risk and outcomes. Two authors independently searched the Web of Science, Pubmed, EBSCO and Ovid MEDLINE resources with the key words "vitamin D, lung cancer, solar and latitude" and enrolled 22 studies that satisfied the inclusion criteria. The summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the random (or fixed)-effects model. Potential confounders were carefully adjusted. High vitamin D (or calcium) intake and serum 25(OH)D levels each correlated inversely with lung cancer risk [OR = 0...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28674506/sun-exposure-and-psychotic-experiences
#19
Izabela Pilecka, Sven Sandin, Abraham Reichenberg, Robert K R Scragg, Anthony David, Elisabete Weiderpass
OBJECTIVE: Sun exposure is considered the single most important source of vitamin D. Vitamin D deficiency has been suggested to play a role in the etiology of psychotic disorders. The aim of the present study was to evaluate the association between sun exposure and psychotic experiences (PEs) in a general population sample of Swedish women. METHODS: The study population included participants from The Swedish Women's Lifestyle and Health cohort study. The 20-item community assessment of psychic experiences (CAPEs) was administered between ages 30 and 50 to establish PEs...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28674149/serum-25-hydroxyvitamin-d-level-chronic-diseases-and-all-cause-mortality-in-a-population-based-prospective-cohort-the-hunt-study-norway
#20
Yi-Qian Sun, Arnulf Langhammer, Frank Skorpen, Yue Chen, Xiao-Mei Mai
OBJECTIVE: To investigate the association of vitamin D status with all-cause mortality in a Norwegian population and the potential influences of existing chronic diseases on the association. DESIGN: A population-based prospective cohort study. SETTING: Nord-Trøndelag County, Norway. PARTICIPANTS: A random sample (n=6613) of adults aged 20 years or older in a cohort. METHODS: Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in blood samples collected at baseline (n=6377)...
July 3, 2017: BMJ Open
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