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vitamin D and sun

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https://www.readbyqxmd.com/read/27895587/vitamin-d-signaling-through-induction-of-paneth-cell-defensins-maintains-gut-microbiota-and-improves-metabolic-disorders-and-hepatic-steatosis-in-animal-models
#1
Danmei Su, Yuanyang Nie, Airu Zhu, Zishuo Chen, Pengfei Wu, Li Zhang, Mei Luo, Qun Sun, Linbi Cai, Yuchen Lai, Zhixiong Xiao, Zhongping Duan, Sujun Zheng, Guihui Wu, Richard Hu, Hidekazu Tsukamoto, Aurelia Lugea, Zhenqui Liu, Stephen J Pandol, Yuan-Ping Han
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed. On the other hand, disorder of gut microbiota, namely dysbiosis, is known to cause MetS and NAFLD. It is also known that systemic inflammation blocks insulin signaling pathways, leading to insulin resistance and glucose intolerance, which are the driving force for hepatic steatosis...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27892584/a-short-history-of-phototherapy-vitamin-d-and-skin-disease
#2
Paul Jarrett, Robert Scragg
The earliest record between sun exposure and skin disease goes back five millennia to the ancient Egyptians. The modern scientific era of medical light therapy and skin diseases started in 1877 when Downs and Blunt reported that exposure to light inhibited fungal growth in test tubes. Continuing research generated a growing medical interest in the potential the effects of light to treat and cure skin diseases considered as parasitic. This culminated in the awarding of the 1903 Nobel Prize in Medicine to Niels Finsen for his pioneering work showing that light could successfully treat cutaneous mycobacterium tuberculosis (lupus vulgaris), a disfiguring disorder common at the time...
November 28, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27881169/spatiotemporal-exposure-modeling-of-ambient-erythemal-ultraviolet-radiation
#3
Trang VoPham, Jaime E Hart, Kimberly A Bertrand, Zhibin Sun, Rulla M Tamimi, Francine Laden
BACKGROUND: Ultraviolet B (UV-B) radiation plays a multifaceted role in human health, inducing DNA damage and representing the primary source of vitamin D for most humans; however, current U.S. UV exposure models are limited in spatial, temporal, and/or spectral resolution. Area-to-point (ATP) residual kriging is a geostatistical method that can be used to create a spatiotemporal exposure model by downscaling from an area- to point-level spatial resolution using fine-scale ancillary data...
November 24, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#4
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27865354/vitamin-d-supplementation-reduces-insulin-resistance-in-japanese-adults-a-secondary-analysis-of-a-double-blind-randomized-placebo-controlled-trial
#5
Xiaomin Sun, Zhen-Bo Cao, Kumpei Tanisawa, Tomoko Ito, Satomi Oshima, Mitsuru Higuchi
Higher circulating 25-hydroxyvitamin D (25[OH]D) concentration has been linked to a lower prevalence of insulin resistance and type 2 diabetes mellitus. However, randomized controlled trials have not clarified the effect of vitamin D supplementation on insulin resistance in healthy adults. The objective of this study was to assess the effect of vitamin D supplementation for 1 year on insulin resistance; the study was a secondary analysis of a clinical trial. We hypothesized that increased 25(OH)D concentration after vitamin D supplementation for 1 year would significantly improve insulin resistance...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27861336/serum-25-hydroxyvitamin-d-level-is-associated-with-myopia-in-the-korea-national-health-and-nutrition-examination-survey
#6
Jin-Woo Kwon, Jin A Choi, Tae Yoon La
The aim of this article was to assess the associations of serum 25-hydroxyvitamin D [25(OH)D] and daily sun exposure time with myopia in Korean adults.This study is based on the Korea National Health and Nutrition Examination Survey (KNHANES) of Korean adults in 2010-2012; multiple logistic regression analyses were performed to examine the associations of serum 25(OH)D levels and daily sun exposure time with myopia, defined as spherical equivalent ≤-0.5D, after adjustment for age, sex, household income, body mass index (BMI), exercise, intraocular pressure (IOP), and education level...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858878/association-between-pulmonary-fibrosis-and-osteoporosis-in-the-elderly-people-a-case-control-study
#7
Zhong Xie, Yanhong He, Yongqiang Sun, Zhanzhan Lin, Mingzhi Yang, Qian Liu, Sihai Liu
In this case-control study, we evaluated the association between osteoporosis and pulmonary fibrosis in the elderly. Participants were divided into a test group and a control group depending on bone mineral density and grid pattern changes of pulmonary fibrosis. We measured general conditions, related risk factors, serum biochemical index, grid pattern changes of double lungs, pulmonary function, arterial oxygen pressure (PO2), and bone mineral density of participates, and investigated the data through statistical analysis on SPSS 17...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855629/vitamin-d-and-the-epigenetic-machinery-in-colon-cancer
#8
Meiyan Sun, Bin Guo
Vitamin D is an important hormone that regulates many physiological processes related to human health. Through its nuclear receptor, VDR, vitamin D controls gene expression through genetic and epigenetic mechanisms. Increasing data have demonstrated the anti-cancer activities of vitamin D in various cancers, including colon cancer. This review summarizes the recent progresses in our understanding of the molecular mechanisms of vitamin D and its interaction with the epigenetic machinery in colon cancer. Vitamin D changes the status of DNA methylation and histone modifications, resulting in the activation of tumor suppressors and inhibition of oncogenes...
November 17, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27855294/evidence-for-the-vitamin-d-hypothesis-the-nhanes-iii-extended-mortality-follow-up
#9
Ahmad H Daraghmeh, Monica L Bertoia, Mazen O Al-Qadi, Abdulrahman M Abdulbaki, Mary B Roberts, Charles B Eaton
BACKGROUND AND AIMS: Emerging evidence suggests that low levels of vitamin D may be an important risk factor for multiple chronic diseases and mortality, but the evidence is mixed. Vitamin D levels are associated with sun exposure, diet, and metabolic status. One potential explanation for the lack of consistent findings amongst various studies is that low vitamin levels may be associated with poor diets or other risk factors that we were not adequately controlled for in different analyses...
April 9, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27851719/the-correlation-between-serum-vitamin-d-deficiency-and-preterm-birth
#10
Lixia Yang, Shilei Pan, Yufeng Zhou, Xiaoyang Wang, Aikai Qin, Yuxin Huang, Suxia Sun
BACKGROUND Preterm birth is an important cause of death and developmental disorder in neonates. Vitamin D deficiency has been shown to regulate body inflammatory factor levels that stimulate elevation of uterine contraction hormones, such as prostaglandin, thus causing preterm birth. However, current observations regarding the relationship between vitamin D and preterm birth are inconsistent. We performed a nested case-control study to investigate the effect of vitamin D on preterm birth. MATERIAL AND METHODS A prospective cohort study included 200 cases of pregnant women in our hospital from May 2013 to May 2015...
November 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27845705/what-do-people-know-and-believe-about-vitamin-d
#11
Mélanie Deschasaux, Jean-Claude Souberbielle, Valentin Partula, Lucie Lécuyer, Rebeca Gonzalez, Bernard Srour, Christiane Guinot, Denis Malvy, Paule Latino-Martel, Nathalie Druesne-Pecollo, Pilar Galan, Serge Hercberg, Emmanuelle Kesse-Guyot, Philippine Fassier, Khaled Ezzedine, Mathilde Touvier
People have been exposed to a lot of information regarding vitamin D, with evidence suggesting that vitamin D may be involved in numerous health conditions, subsequently creating concerns about vitamin D insufficiency. As a result, what do people really know or believe about this topic? In this cross-sectional study, we assessed vitamin D-related knowledge and beliefs in 59,273 French adults (NutriNet-Santé cohort) using a specific questionnaire. Answers to this questionnaire were weighted according to the French sociodemographic distribution and compared across individual characteristics, using χ²-tests...
November 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27836631/low-serum-vitamin-d-levels-and-anti-n-methyl-d-aspartate-receptor-encephalitis-a-case-control-study
#12
Yaqing Shu, Qingmei Su, Siyuan Liao, Tingting Lu, Rui Li, Xiaobo Sun, Wei Qiu, Yu Yang, Xueqiang Hu, Zhengqi Lu
BACKGROUND: Low vitamin D levels are associated with autoimmunity, but the relationship with anti-N-Methyl-d-aspartate receptor (anti-NMDAR) encephalitis is unknown. METHODS: 25(OH) D levels and clinical and cerebrospinal fluid parameters were evaluated in 30 patients with anti-NMDAR encephalitis and compared with 90 age-, sex-, and season-matched healthy controls. RESULTS: 25(OH)D levels were lower in patients with anti-NMDAR encephalitis compared to controls (43...
November 8, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27834434/uvr-sun-lamps-pigmentation-and-vitamin-d
#13
C M Lerche, P A Philipsen, H C Wulf
Exposure to ultraviolet radiation (UVR) has important and significant consequences on human health. Recently, there has been renewed interest in the beneficial effects of UVR. This perspective gives an introduction to the solar spectrum, UV lamps, UV dosimetry, skin pigment and vitamin D. The health benefits of UVR exposure through vitamin D production or non-vitamin D pathways will be discussed in this themed issue in the following articles.
November 11, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27832208/low-skeletal-muscle-mass-in-the-lower-limbs-is-independently-associated-to-knee-osteoarthritis
#14
Sang Yoon Lee, Hee Joon Ro, Sun G Chung, Si Hyun Kang, Kyung Mook Seo, Don-Kyu Kim
OBJECTIVES: It has been reported that low skeletal muscle mass correlates with knee osteoarthritis in obese individuals. This study aimed to investigate whether lower limb skeletal muscle mass is independently associated with knee osteoarthritis in the general population. MATERIALS AND METHODS: This cross-sectional study used public data from the Fourth and Fifth Korean National Health and Nutrition Examination Survey. Subjects included 4924 community-dwelling adults aged ≥50 years (821 subjects with knee osteoarthritis and 4,103 controls)...
2016: PloS One
https://www.readbyqxmd.com/read/27810275/serum-25-hydroxyvitamin-d-and-mental-health-in-young-australian-women-results-from-the-safe-d-study
#15
Emma T Callegari, Nicola Reavley, Alexandra Gorelik, Suzanne M Garland, John D Wark
BACKGROUND: While there is evidence linking vitamin D status with mood, this association and its clinical significance remain uncertain. Moreover, few studies have focused on young, community-dwelling females. The Safe-D study examined the association between serum 25-hydroxyvitamin D (25OHD) levels and mental health in young women. METHODS: Participants completed an online questionnaire, wore a UV dosimeter to measure personal sun exposure and underwent a comprehensive health assessment...
October 14, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27800526/vitamin-d-as-adjunctive-host-directed-therapy-in-tuberculosis-a-systematic-review
#16
REVIEW
Robert S Wallis, Alimuddin Zumla
Vitamin D plays an important role in innate defenses against intracellular pathogens. Seasonal vitamin D insufficiency (VDI) due to reduced sun exposure far from the equator increases tuberculosis risk. Eight randomized controlled trials examined vitamin D as adjunctive therapy during tuberculosis treatment. The studies varied substantially regarding patient genetic backgrounds, the extent of baseline VDI, the administered dose, the study endpoints, and the quality of the reported data. One carefully performed study in which moderately large vitamin D doses were given to markedly VDI patients found a benefit sufficient to support shortening treatment from 6 to 4 months, although other similar studies did not...
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27792059/vitamin-d-receptor-immunohistochemistry-variability-in-sun-exposed-and-non-sun-exposed-melanomas
#17
Giovanni Paolino, Chiara Panetta, Carlo Cota, Dario Didona, Elisa Moliterni, Cinzia Di Mattia, Gaetano De Vita, Ugo Bottoni, Pietro Donati, Stefano Calvieri
Ultraviolet rays are one of the leading factors in the development of melanoma (MM); however, ultraviolet rays seem not to play a role in non-sun-exposed MM, where systemic immunosuppression, anatomical, and physiological features may contribute toward the development of the malignancy. Our aim was to evaluate vitamin D receptor (VDR) expression in shield-site melanoma (ST-MM) and non-shield-site melanoma (NST-MM) to find features that could explain the different biological behavior of MM according to the area of onset...
October 27, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27785744/bone-mineral-density-in-children-with-acute-leukemia-and-its-associated-factors-in-iran-a-case-control-study
#18
Mohammad Reza Bordbar, Sezaneh Haghpanah, Mohammad Hossein Dabbaghmanesh, Gholamhossein Ranjbar Omrani, Forough Saki
: Acute leukemia is the most common malignancy in children. We showed that low bone mass is prevalent among children with leukemia, especially in femur. Serum calcium, exercise, chemotherapy protocol, and radiotherapy are the main contributing factors. We suggest that early diagnosis and treatment of this problem could improve bone health in them. INTRODUCTION: Acute leukemia is the most common malignancy in children and has been reported to be associated with low bone mass...
December 2016: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27785049/preventive-effect-of-zoledronic-acid-on-aromatase-inhibitor-associated-bone-loss-for-postmenopausal-breast-cancer-patients-receiving-adjuvant-letrozole
#19
Shengliang Sun, Fuchao Wang, Honglei Dou, Longqiang Zhang, Jiwen Li
BACKGROUND: This study aims to compare the efficacy and safety between zoledronic acid combined with calcium and calcium alone to prevent aromatase inhibitor-associated bone loss for postmenopausal breast cancer patients receiving adjuvant letrozole. METHODS: One hundred twenty patients were randomly divided into two groups, A and B. Patients in group A (n=60) received modified radical mastectomy or breast-conserving surgery + four cycles of AC followed by T regimen (optional) + radiotherapy (optional) + letrozole 2...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27783655/relationship-between-serum-vitamin-d-status-and-metabolic-risk-factors-among-korean-adults-with-prediabetes
#20
Han Na Kwon, Hyunjung Lim
Serum vitamin D status has been associated with prediabetes and metabolic syndrome. Evidence for the increased risk of metabolic disorders in individuals with prediabetes and a low vitamin D status is limited and uncertain. Furthermore, it has not been confirmed whether this possible relationship occurs in the Korean population. The aim of this study was to assess serum vitamin D status and to examine the relationship between serum vitamin D levels and metabolic risk factors in Korean adults with prediabetes...
2016: PloS One
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