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https://www.readbyqxmd.com/read/28102953/air-kerma-strength-determination-of-an-hdr-192-ir-source-including-a-geometric-sensitivity-study-of-the-seven-distance-method
#1
Blake R Smith, John A Micka, Manik Aima, Larry A DeWerd, Wesley S Culberson
PURPOSE: To perform an in-air air-kerma strength (SK) calibration of the Bebig model Ir2.A85-2 192Ir high-dose rate (HDR) brachytherapy source manufactured by Mallinckrodt Medical (Westerduinweg, Germany) with the NIST-traceable seven-distance technique established by the University of Wisconsin. A comparison was made between the reference air-kerma rate (RAKR) reported on a certificate from the Physikalisch-Technische Bundesanstalt (Berlin, Germany) (PTB) primary laboratory and the SK determined at the University of Wisconsin Madison Radiation Research Center (UWMRRC)...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28101943/stability-of-color-in-spanish-style-green-table-olives-pasteurized-and-stored-in-plastic-containers
#2
Antonio Higinio Sánchez, Antonio López-López, Víctor Manuel Beato, Antonio de Castro, Alfredo Montaño
BACKGROUND: There is an increasing interest in the use of pasteurizable plastic packaging by the olive industry. In order to investigate the change from traditional glass or varnished can containers to plastic packaging, the proper plastic material that is compatible with fermented olives while maintaining color quality during pasteurization treatment and storage must be selected. This work is focused on color stability in two distinct pasteurizable plastic containers with different oxygen permeability...
January 19, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28101592/long-term-safety-and-outcome-of-fludarabine-cyclophosphamide-and-mitoxantrone-fcm-regimen-in-previously-untreated-patients-with-advanced-follicular-lymphoma-12%C3%A2-years-follow-up-of-a-phase-2-trial
#3
Laura Magnano, Silvia Montoto, Eva González-Barca, Javier Briones, Juan Manuel Sancho, Ana Muntañola, Antonio Salar, Joan Besalduch, Lourdes Escoda, Carol Moreno, Eva Domingo-Domenech, Cristina Estany, Albert Oriol, Albert Altés, Carmen Pedro, Santiago Gardella, Antoni Asensio, Pilar Vivancos, Alberto Fernández de Sevilla, Josep María Ribera, Dolors Colomer, Elias Campo, Armando López-Guillermo
Fludarabine combinations are very affective in follicular lymphoma (FL) with high rates of complete response and prolonged survival. However, late toxicities could be a concern. The aim of the present study was to analyze the long-term impact on survival, relapse and late toxicities of a trial of treatment with fludarabine, mitoxantrone and cyclophosphamide (FCM regimen) for untreated patients with advanced stage FL. One hundred and twenty patients enrolled in a phase 2 trial of treatment with FCM regimen between 2000 and 2003 were evaluated...
January 18, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28101457/therapeutic-effects-of-omega-3-fatty-acids-on-chronic-kidney-disease-associated-pruritus-a-literature-review
#4
REVIEW
Yunes Panahi, Simin Dashti-Khavidaki, Farahnoosh Farnood, Hamid Noshad, Mahsa Lotfi, Afshin Gharekhani
Uremic pruritus remains one of the most tormenting, frequent and potentially disabling problem in chronic kidney disease (CKD) patients. However, an area of substantial etiological interest with relation to uremic pruritus is the essential fatty acids deficiency. So we performed a literature review to elucidate the efficacy of omega-3 fatty acids on uremic pruritus. This review evaluated all of the studies published in English language, focusing on the clinical effects of omega-3 fatty acids on uremic pruritus...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28101428/wide-field-and-highly-sensitive-angiography-based-on-optical-coherence-tomography-with-akinetic-swept-source
#5
Jingjiang Xu, Shaozhen Song, Wei Wei, Ruikang K Wang
Wide-field vascular visualization in bulk tissue that is of uneven surface is challenging due to the relatively short ranging distance and significant sensitivity fall-off for most current optical coherence tomography angiography (OCTA) systems. We report a long ranging and ultra-wide-field OCTA (UW-OCTA) system based on an akinetic swept laser. The narrow instantaneous linewidth of the swept source with its high phase stability, combined with high-speed detection in the system enable us to achieve long ranging (up to 46 mm) and almost negligible system sensitivity fall-off...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28100485/quantification-of-growth-factor-signaling-and-pathway-crosstalk-by-live-cell-imaging
#6
Sean M Gross, Peter Rotwein
Peptide growth factors stimulate cellular responses through activation of their trans-membrane receptors. Multiple intracellular signaling cascades are engaged following growth factor - receptor binding, leading to short- and long-term biological effects. Each receptor-activated signaling pathway does not act in isolation, but rather interacts at different levels with other pathways to shape signaling networks that are distinctive for each growth factor. To gain insights into the specifics of growth factor-regulated interactions among different signaling cascades, we developed a HeLa cell line stably expressing fluorescent live-cell imaging reporters that are readouts for two major growth factor-stimulated pathways, Ras - Raf - Mek - Erk and PI3-kinase - Akt...
January 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28100125/sulphur-dioxide-in-meat-products-3-years-control-results-of-an-accredited-italian-laboratory
#7
Marco Iammarino, Anna Rita Ientile, Aurelia Di Taranto
Sulphiting agents are well-known food preservatives. The European legislation does not allow their addition in fresh meat preparations. Therefore this type of food products has often been verified. To high sulphite levels in food is a health safety risk, due to toxic effects that these compounds may exercise on humans. In this study the control activity as performed by an Italian accredited laboratory from 2013 to 2015, relating to determination of sulphites in meat products, is described. Six hundred and sixty-nine meat product samples were analysed...
January 19, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28098991/evidence-of-absence-estrogenicity-assessment-of-a-new-food-contact-coating-and-the-bisphenol-used-in-its-synthesis
#8
Ana M Soto, Cheryl Schaeberle, Mark S Maier, Carlos Sonnenschein, Maricel V Maffini
Consumer concerns about exposure to substances found in food contact materials with estrogenic activity (EA) have created substantial demand for alternatives. We assessed the potential EA of both a new bisphenol monomer used to synthesize polymeric coatings for metal food-contact applications and the nonintentionally added substances (NIAS) that may migrate into food. We evaluated tetramethyl bisphenol F (TMBPF) using in vitro and in vivo assays. We extracted the polymeric coating using food simulants ethanol (50% v/v) and acetic acid (3% w/v) and measured migration using tandem liquid chromatography (LC)/mass spectrometry (MS) and LC time-of-flight MS for TMBPF and NIAS, respectively...
January 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28098666/estimated-internal-and-external-radiation-exposure-of-caregivers-of-patients-with-pediatric-neuroblastoma-undergoing-131i-metaiodobenzylguanidine-therapy-a-prospective-pilot-study
#9
Sangwon Han, Seon Hee Yoo, Kyung-Nam Koh, Jong Jin Lee
PURPOSE: Current recommendations suggest that family members should participate in the care of children receiving in-hospital I metaiodobenzylguanidine (MIBG) therapy for neuroblastoma. The present study aimed to measure the external radiation exposure and estimate the internal radiation exposure of caregivers during the hospital stay for I MIBG therapy. MATERIALS AND METHODS: Caregivers received radiation safety instructions and a potassium iodide solution for thyroid blockade before patient admission...
January 16, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28098267/a-tailored-multi-frequency-epr-approach-to-accurately-determine-the-magnetic-resonance-parameters-of-dynamic-nuclear-polarization-agents-application-to-amupol
#10
P Gast, D Mance, E Zurlo, K L Ivanov, M Baldus, M Huber
To understand the dynamic nuclear polarization (DNP) enhancements of biradical polarizing agents, the magnetic resonance parameters need to be known. We describe a tailored EPR approach to accurately determine electron spin-spin coupling parameters using a combination of standard (9 GHz), high (95 GHz) and ultra-high (275 GHz) frequency EPR. Comparing liquid- and frozen-solution continuous-wave EPR spectra provides accurate anisotropic dipolar interaction D and isotropic exchange interaction J parameters of the DNP biradical AMUPol...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28098063/the-use-of-e-cigarettes
#11
Martin Eichler, Maria Blettner, Susanne Singer
BACKGROUND: Electronic cigarettes (e-cigarettes) are a consumer product whose benefits and risks are currently debated. Advocates of the "tobacco harm reduction" strategy emphasize their potential as an aid to smoking cessation, while advocates of the precautionary principle emphasize their risks instead. There have been only a few studies to date on the prevalence of e-cigarette use in Germany. METHODS: In May 2016, in collaboration with Forsa, an opinion research firm, we carried out a survey among 4002 randomly chosen persons aged 14 and older, asking them about their consumption of e-cigarettes with and without nicotine, reasons for using e-cigarettes, plans for future use, estimation of danger compared to that of tobacco products, smoking behavior, and sociodemographic features...
December 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28097911/design-synthesis-and-docking-study-of-novel-coumarin-ligands-as-potential-selective-acetylcholinesterase-inhibitors
#12
Fatih Sonmez, Belma Zengin Kurt, Isil Gazioglu, Livia Basile, Aydan Dag, Valentina Cappello, Tiziana Ginex, Mustafa Kucukislamoglu, Salvatore Guccione
New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and in vitro tested as acetylcholinesterase (AChE) inhibitors. 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acetamide (6c, IC50 value of 43 nM) was the best AChE inhibitor with a selectivity index of 4151.16 over BuChE. Kinetic study of AChE inhibition revealed that 6c was a mixed-type inhibitor. Moreover, the result of H4IIE hepatoma cell toxicity assay for 6c showed negligible cell death...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28097508/preparation-and-evaluation-of-biopolymeric-nanoparticles-as-drug-delivery-system-in-effective-treatment-of-rheumatoid-arthritis
#13
Vijay Kumar, Ankita Leekha, Aakriti Tyagi, Ankur Kaul, Anil Kumar Mishra, Anita Kamra Verma
PURPOSE: The study purposes to evaluate nanocrystalline biopolymeric nanoparticles encapsulating methotrexate and dexamethasone with high biocompatibility, enhanced therapeutic efficacy and reduced toxicity. METHODS: Chitosan nanoparticles were prepared by ionic gelation, and Methotrexate (MTX) and Dexamethasone (DEX) were loaded during the preparation and screened for their in vitro efficacy in HEK and RAW264.7 cells, ex vivo and in vivo efficacy. RESULTS: FTIR confirmed the involvement of phosphoric group of sTPP with amine groups of chitosan and also role of hydrogen bonding involved in the preparation of MTXCHNP and DEXCHNP...
January 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28097216/the-last-frontiers-of-wilderness-tracking-loss-of-intact-forest-landscapes-from-2000-to-2013
#14
Peter Potapov, Matthew C Hansen, Lars Laestadius, Svetlana Turubanova, Alexey Yaroshenko, Christoph Thies, Wynet Smith, Ilona Zhuravleva, Anna Komarova, Susan Minnemeyer, Elena Esipova
An intact forest landscape (IFL) is a seamless mosaic of forest and naturally treeless ecosystems with no remotely detected signs of human activity and a minimum area of 500 km(2). IFLs are critical for stabilizing terrestrial carbon storage, harboring biodiversity, regulating hydrological regimes, and providing other ecosystem functions. Although the remaining IFLs comprise only 20% of tropical forest area, they account for 40% of the total aboveground tropical forest carbon. We show that global IFL extent has been reduced by 7...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28095593/automated-face-detection-for-occurrence-and-occupancy-estimation-in-chimpanzees
#15
Anne-Sophie Crunchant, Monika Egerer, Alexander Loos, Tilo Burghardt, Klaus Zuberbühler, Katherine Corogenes, Vera Leinert, Lars Kulik, Hjalmar S Kühl
Surveying endangered species is necessary to evaluate conservation effectiveness. Camera trapping and biometric computer vision are recent technological advances. They have impacted on the methods applicable to field surveys and these methods have gained significant momentum over the last decade. Yet, most researchers inspect footage manually and few studies have used automated semantic processing of video trap data from the field. The particular aim of this study is to evaluate methods that incorporate automated face detection technology as an aid to estimate site use of two chimpanzee communities based on camera trapping...
January 17, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28094990/bridging-the-gap-between-dielectric-nanophotonics-and-the-visible-regime-with-effectively-lossless-gap-antennas
#16
Javier Cambiasso, Gustavo Grinblat, Yi Li, Aliaksandra Rakovich, Emiliano Cortés, Stefan A Maier
We present all-dielectric gallium phosphide (GaP) nanoantennas as an efficient nanophotonic platform for surface-enhanced second harmonic generation (SHG) and fluorescence (SEF), showing negligible losses in the visible range. Employing single GaP nanodisks, we observe an increase of more than three orders of magnitude in the SHG signal in comparison with the bulk. This constitutes an SHG efficiency as large as 0.0002%, which is, to the best of our knowledge, the highest yet achieved value produced by a single nano-object in the optical region...
January 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28094950/capillary-force-induced-cold-welding-in-silver-nanowire-based-flexible-transparent-electrodes
#17
Yuan Liu, Jianming Zhang, Heng Gao, Yan Wang, Qingxian Liu, Siya Huang, Chuanfei Guo, Zhifeng Ren
Silver nanowire (AgNW) films have been studied as the most promising flexible transparent electrodes for flexible photoelectronics. The wire-wire junction resistance in the AgNW film is a critical parameter to the electrical performance, and several techniques of nanowelding or soldering have been reported to reduce the wire-wire junction resistance. However, these methods require either specific facilities, or additional materials as the "solder", and often have adverse effects to the AgNW film or substrate...
January 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28094625/nursingstandard-com
#18
(no author information available yet)
1 A nurse who gave a patient who later died the wrong type of blood has been convicted of unlawful killing by gross negligence. Read more: rcni.com/blood-type.
January 4, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28094449/genetic-diversity-and-patterns-of-population-structure-in-creole-goats-from-the-americas
#19
C Ginja, L T Gama, A Martínez, N Sevane, I Martin-Burriel, M R Lanari, M A Revidatti, J A Aranguren-Méndez, D O Bedotti, M N Ribeiro, P Sponenberg, E L Aguirre, L A Alvarez-Franco, M P C Menezes, E Chacón, A Galarza, N Gómez-Urviola, O R Martínez-López, E C Pimenta-Filho, L L da Rocha, A Stemmer, V Landi, J V Delgado-Bermejo
Biodiversity studies are more efficient when large numbers of breeds belonging to several countries are involved, as they allow for an in-depth analysis of the within- and between-breed components of genetic diversity. A set of 21 microsatellites was used to investigate the genetic composition of 24 Creole goat breeds (910 animals) from 10 countries to estimate levels of genetic variability, infer population structure and understand genetic relationships among populations across the American continent. Three commercial transboundary breeds were included in the analyses to investigate admixture with Creole goats...
January 17, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28094184/in-vivo-evaluation-of-igf1r-ir-pet-ligand-18-f-bms-754807-in-rodents
#20
Jaya Prabhakaran, Stephen L Dewey, Richard McClure, Norman R Simpson, Mohammed N Tantawy, J John Mann, Wellington Pham, J S Dileep Kumar
In vivo evaluation of [(18)F]BMS-754807 binding in mice and rats using microPET and biodistribution methods is described herein. The radioligand shows consistent binding characteristics, in vivo, in both species. Early time frames of the microPET images and time activity curves of brain indicate poor penetration of the tracer across the blood brain barrier (BBB) in both species. However, microPET experiments in mice and rats show high binding of the radioligand outside the brain to heart, pancreas and muscle, the organs known for higher expression of IGF1R/1R...
January 7, 2017: Bioorganic & Medicinal Chemistry Letters
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