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https://www.readbyqxmd.com/read/29679805/poly-l-lysine-modified-cryogels-for-efficient-bilirubin-removal-from-human-plasma
#1
Mehmet Emin Çorman
In this study, poly-l-lysine (PLL) immobilized PHEMA cryogel was designed for the specific bilirubin removal from human plasma. The surface of PHEMA cryogels is surrounded by PLL chains to enhance specific binding of bilirubin molecules via specific complementary electrostatic interactions. The functionalization of the PHEMA cryogel was carried out by direct coupling of PLL to pre-activated OH-group of the HEMA alcohol units via carbodiimide activation. Prior to removal of bilirubin from human plasma, the optimization parameters including, initial bilirubin concentration, flow rate, temperature, ionic strength, and adsorption rates on adsorption of PLL-PHEMA cryogel were investigated from the aqueous medium...
April 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29679292/preparation-and-optimization-lipid-nanocapsules-to-enhance-the-antitumor-efficacy-of-cisplatin-in-hepatocellular-carcinoma-hepg2-cells
#2
Qingqing Zhai, Hailong Li, Yanlin Song, Ruijiao Wu, Chuanfang Tang, Xiaodong Ma, Zhihao Liu, Jinyong Peng, Jianbin Zhang, Zeyao Tang
This work aimed to develop and optimize several lipid nanocapsule formulations (LNCs) to encapsulate cisplatin (CDDP) for treatment of hepatocellular carcinoma. By comparing the effect of oil/surfactant ratio, lecithin content, and oil/surfactant type on LNC characteristics, two LNCs were selected as optimal formulations: HS15-LNC (Solutol HS 15/MCT/lecithin, 54.5:42.5:3%, w/w) and EL-LNC (Cremophor EL/MCT/lecithin, 54.5:42.5:3%, w/w). Both LNCs could effectively encapsulate CDDP with the encapsulation efficiency of 73...
April 20, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29679260/slow-release-of-hiv-1-protein-nef-from-vesicle-like-structures-is-inhibited-by-cytosolic-calcium-elevation-in-single-human-microglia
#3
Matjaž Stenovec, Eva Lasič, Pia Pužar Dominkuš, Saša Trkov Bobnar, Robert Zorec, Metka Lenassi, Marko Kreft
Once infected by HIV-1, microglia abundantly produce accessory protein Nef that enhances virus production and infectivity, but little is known about its intracellular compartmentalization, trafficking mode(s), and release from microglia. Here, we transfected immortalized human microglia with a plasmid encoding Nef tagged with green fluorescent protein (Nef.GFP) to biochemically and microscopically identify Nef.GFP-associated cellular compartments and examine their mobility and Nef release from cultured cells...
April 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29679203/a-window-into-extreme-longevity-the-circulating-metabolomic-signature-of-the-naked-mole-rat-a-mammal-that-shows-negligible-senescence
#4
Kaitlyn N Lewis, Nimrod D Rubinstein, Rochelle Buffenstein
Mouse-sized naked mole-rats (Heterocephalus glaber), unlike other mammals, do not conform to Gompertzian laws of age-related mortality; adults show no age-related change in mortality risk. Moreover, we observe negligible hallmarks of aging with well-maintained physiological and molecular functions, commonly altered with age in other species. We questioned whether naked mole-rats, living an order of magnitude longer than laboratory mice, exhibit different plasma metabolite profiles, which could then highlight novel mechanisms or targets involved in disease and longevity...
April 20, 2018: GeroScience
https://www.readbyqxmd.com/read/29678488/medicolegal-considerations-involving-iatrogenic-lingual-nerve-damage
#5
REVIEW
Roberto Pippi, Andrea Spota, Marcello Santoro
The aim of this review is to improve risk management strategies through analysis of the anatomic, semeiotic, and medicolegal aspects that characterize iatrogenic lingual nerve damage (LND) and its legal consequences in the case of legal proceedings for a claim for compensation. In dental practice, LND can be caused by local or general anesthesia or by mechanical, chemical, or thermal mechanisms. A certain postoperative identification of LND etiopathogenesis is often very challenging because it can be difficult to show at what time the damage occurred and which mechanism actually caused it...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29678456/inflatable-penile-prosthesis-placement-scratch-technique-and-postoperative-vacuum-therapy-as-a-combined-approach-in-the-definitive-treatment-of-patients-with-peyronie-s-disease
#6
G Antonini, E De Berardinis, F Del Giudice, G M Busetto, S Lauretti, R Fragas, B I Chung, S L Conti, D Giannarelli, I Sperduti, M S Gross, P E Perito
PURPOSE: Peyronie's disease (PD) is a devastating condition resulting in penile deformity, erectile dysfunction (ED), pain and emotional distress. This prospective two institution study evaluates a multimodal surgical and mechanical combined approach in the definitive treatment of PD and concomitant ED. MATERIALS AND METHODS: 145 selected patients underwent endocavernosal disruption of the PD plaques via the "scratch technique" followed by inflatable penile prosthesis (IPP) insertion...
April 17, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29677228/decontamination-of-customized-laser-microtextured-titanium-abutments-a-comparative-in-vitro-study-of-different-cleaning-procedures
#7
Davide Farronato, Davide Fumagalli, Farah Asa'ad, Giulio Rasperini
The aim of this study was to evaluate different cleaning procedures for customized laser-microtextured titanium abutments. A total of 20 customized laser-microtextured abutments were randomized into four groups: no cleaning (control group), ultrasonic treatments + autoclave cycle (group 1), ultrasonic treatments + argon plasma (group 2), and only argon plasma (group 3). Surface contaminants were assessed through scanning electron microscopy and energy-dispersive x-ray spectroscopy microanalysis. In the control group, 99...
April 20, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29676967/municipal-solid-waste-generation-and-disposal-in-robe-town-ethiopia
#8
Duguma Erasu, Tesfaye Faye, Amaha Kiros, Abel Balew
The amount of solid waste generated in developing countries is rising from time to time due to economic growth, change in consumer behavior and lifestyles of people. But it is hard to manage and handle the increase of solid waste with existing waste management infrastructure. Thus, the management system of solid waste is very poor and become a serious problem. The main purpose of this study is to quantify the volume of solid waste generated and investigate factors affecting generation and disposal of wastes in the study area...
April 20, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29676908/fluorine-grafted-cu7s4-au-heterodimers-for-multimodal-imaging-guided-photothermal-therapy-with-high-penetration-depth
#9
Jiabin Cui, Rui Jiang, Chang Guo, Xilin Bai, Suying Xu, Leyu Wang
We report the multifunctional nanocomposites (NCs) consisting of 19F-moieties grafted Cu7S4-Au nanoparticles (NPs) through click chemistry for sensitive and negligible background 19F-magnetic resonance imaging (19F-MRI) and computed tomography (CT) imaging guided photothermal therapy. The localized surface plasmon resonance (LSPR) peak can be reasonably tuned to the in vivo transparent window (800-900 nm) by coupling Au NPs (<10 nm, LSPR 530 nm) with Cu7S4 NPs (<15 nm, LSPR 1500 nm) into the Cu7S4-Au heterodimers...
April 20, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29676577/oxidation-of-acid-base-and-amide-side-chain-amino-acid-derivatives-via-hydroxyl-radical
#10
Jon Uranga, Jon I Mujika, Rafael Grande-Aztatzi, Jon M Matxain
Hydroxyl radical (●OH) is known to be highly reactive. Herein, we analyze the oxidation of acid (Asp and Glu), base (Arg and Lys) and amide (Asn and Gln) containing amino acids by the consecutive attack of two ●OH. In this work we study the reaction pathway by means of density functional theory. The oxidation mechanism is divided into two steps: 1) the first ●OH can abstract a H atom or an electron, leading to a radical amino acid derivative, which is the intermediate of the reaction 2) the second ●OH can abstract another H atom or add itself to the formed radical, rendering the final oxidized products...
April 20, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29676505/differential-reactivity-of-metal-binding-domains-of-copper-atpases-towards-cisplatin-and-colocalization-of-copper-and-platinum
#11
Tiantian Fang, Yao Tian, Siming Yuan, Yaping Sheng, Arnesano Fabio, Giovanni Natile, Yangzhong Liu
P-type ATPases, including MNK and WLN proteins, are responsible for active Cu efflux. These ATPases are also associated with resistance to cisplatin. In this work, we produced different metal-binding domains (MBDs) of ATPase (9 out of 12 domains), and compared their reactivity towards cisplatin. The reaction rates of the MBDs can be largely different; the reaction of MNK6 is about 6 times faster than that of WLN2. Copper coordination favors the platination of the MBDs to different extents. The rate of platination was generally grater for holo-MBDs than for apo-MBDS (particularly in the case of WLN4 and WLN2), however it was negligibly affected in the case of MNK6...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29675828/effect-of-prenatal-diagnosis-on-hospital-costs-in-complete-transposition-of-the-great-arteries
#12
Dipankar Gupta, Meredith E Mowitz, Dalia Lopez-Colon, Connie S Nixon, Himesh V Vyas, Jennifer G Co-Vu
OBJECTIVE: Prenatal diagnosis of congenital heart disease (CHD) is associated with improved clinical outcomes, yet its impact on the cost of hospitalization is not well described. We hypothesized that prenatal diagnosis of complete transposition of the great arteries (d-TGA) results in lower total hospital costs compared to postnatal diagnosis. METHODS: Retrospective analysis of infants with d-TGA repaired at our center from July 2006- 2014. Total charges from initial hospitalization until discharge were converted to costs using the cost-to-charge ratio, and then converted into 2016 dollars using the Consumer Price Index...
April 19, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29674520/improved-use-of-small-reference-panels-for-conditional-and-joint-analysis-with-gwas-summary-statistics
#13
Yangqing Deng, Wei Pan
Due to issues of practicality and confidentiality of genomic data-sharing on a large scale, typically only meta- or mega-analyzed GWAS summary data, not individual-level data, are publicly available. Re-analyses of such GWAS summary data for a wide range of applications have become more and more common and useful, which often require the use of an external reference panel with individual-level genotypic data to infer linkage disequilibrium (LD) among genetic variants. However, with a small sample size in only hundreds, as for the most popular 1000 Genomes Project European sample, estimation errors for LD are not negligible, leading to often dramatically increased numbers of false positives in subsequent analyses of GWAS summary data...
April 19, 2018: Genetics
https://www.readbyqxmd.com/read/29674099/anti-fouling-and-thermosensitive-ion-imprinted-nanocomposite-membranes-based-on-grapheme-oxide-and-silicon-dioxide-for-selectively-separating-europium-ions
#14
Jian Lu, Yilin Wu, Xinyu Lin, Jia Gao, Hongjun Dong, Li Chen, Yingying Qin, Liang Wang, Yongsheng Yan
The increasing amount of europium in aqueous environment from rare earth industry has become a serious environmental challenge. Significant efforts have been focused on ion-imprinting membranes (IIMs) for selective separation of ions from analogues. Based on ion-imprinting technique, we have developed Eu3+ -imprinted nanocomposite membranes (Eu-IIMs) for selectively separating Eu3+ from La3+ , Gd3+ and Sm3+ . Polydopamine (pDA) was previously synthesized on basal membranes to augment the interfacial adhesion...
April 12, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29673366/improving-cytocompatibility-of-cdte-quantum-dots-by-schiff-base-coordinated-lanthanides-surface-doping
#15
Hana Buchtelova, Vladislav Strmiska, Zuzana Skubalova, Simona Dostalova, Petr Michalek, Sona Krizkova, David Hynek, Lukas Kalina, Lukas Richtera, Amitava Moulick, Vojtech Adam, Zbynek Heger
BACKGROUND: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable toxicity. This hinders QDs applicability in living systems. Surface chemistry has a profound impact on biological behavior of QDs. This study describes a two-step synthesis of QDs formed by CdTe core doped with Schiff base ligand for lanthanides [Ln (Yb3+ , Tb3+ and Gd3+ )] as novel cytocompatible fluorophores...
April 19, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29673081/sequence-clustering-threshold-has-little-effect-on-the-recovery-of-microbial-community-structure
#16
Synnøve Smebye Botnen, Marie Louise Davey, Rune Halvorsen, Håvard Kauserud
Analysis of microbial community structure by multivariate ordination methods, using data obtained by high throughput sequencing of amplified markers (i.e., DNA metabarcoding), often requires clustering of DNA sequences into operational taxonomic units (OTUs). Parameters for the clustering procedure tend not to be justified but are set by tradition rather than being based on explicit knowledge. In this study, we explore the extent to which ordination results are affected by variation in parameter settings for the clustering procedure...
April 19, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29673030/dengue-fever-and-aedes-aegypti-in-indigenous-brazilians-seroprevalence-risk-factors-knowledge-and-practices
#17
Luciano Pamplona de Góes Cavalcanti, Rafael Henrique Machado Sacramento, Fernanda Montenegro de Carvalho Araújo, Danielle Malta Lima, Carlos Carlos Henrique Alencar, Victor Emanuel Pessoa Martins, Lucas Venâncio Araújo, Tais Castelo de Oliveira
OBJECTIVE: Dengue remains an important public health problem in Brazil. We estimated the associated factors of dengue seroprevalence among native Indians of the Tremembé ethnic and their knowledge about the aspects related to the presence of mosquitoes of the genus Aedes. METHODS: An analytical cross-sectional study and a prospective environmental study to monitor the trapping of mosquito eggs monthly were performed. The serological portion of the study involved indigenous people living in the village of Tapera in northeastern Brazil...
April 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29672964/metasurface-enabled-wide-angle-fourier-lens
#18
Wenwei Liu, Zhancheng Li, Hua Cheng, Chengchun Tang, Junjie Li, Shuang Zhang, Shuqi Chen, Jianguo Tian
Fourier optics, the principle of using Fourier transformation to understand the functionalities of optical elements, lies at the heart of modern optics, and it has been widely applied to optical information processing, imaging, holography, etc. While a simple thin lens is capable of resolving Fourier components of an arbitrary optical wavefront, its operation is limited to near normal light incidence, i.e., the paraxial approximation, which puts a severe constraint on the resolvable Fourier domain. As a result, high-order Fourier components are lost, resulting in extinction of high-resolution information of an image...
April 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29672771/effects-of-subclinical-footpad-dermatitis-and-emotional-arousal-on-surface-foot-temperature-recorded-with-infrared-thermography-in-turkey-toms-meleagris-gallopavo
#19
R O Moe, J Bohlin, A Flø, G Vasdal, H Erlandsen, E Guneriussen, E C Sjökvist, S M Stubsjøen
Footpad dermatitis is a condition that causes lesions on the plantar surface of the footpads in growing turkeys. Potential inflammatory processes and pain associated with increasing severity of footpad dermatitis raise animal welfare concerns. This study investigated whether the temperature of the plantar surface of the foot (the footpads and the entire plantar foot including interdigital membranes) assessed with infrared thermography reflects severity of mild footpad dermatitis as assessed with a Visual Analogue Scale in 80 turkey toms at 10 weeks of age...
April 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/29671603/longitudinal-modeling-of-lung-function-trajectories-in-smokers-with-and-without-copd
#20
James C Ross, Peter J Castaldi, Michael H Cho, Craig P Hersh, Farbod N Rahaghi, Gonzalo V Sánchez-Ferrero, Margaret M Parker, Augusto A Litonjua, David Sparrow, Jennifer G Dy, Edwin K Silverman, George R Washko, Raúl San José Estépar
RATIONALE: The relationship between longitudinal lung function trajectories, chest computed tomography (CT) imaging, and genetic predisposition to COPD has not been explored. OBJECTIVES: 1) To model trajectories using a data-driven approach applied to longitudinal data spanning adulthood in the Normative Aging Study (NAS), and 2) to apply these models to demographically similar subjects in the COPDGene Study with detailed phenotypic characterization including chest CT...
April 19, 2018: American Journal of Respiratory and Critical Care Medicine
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