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https://www.readbyqxmd.com/read/29169203/dissipation-residues-and-risk-assessment-of-spirotetramat-and-its-four-metabolites-in-citrus-and-soil-under-field-conditions-by-lc-ms-ms
#1
Qingtao Zhang, Yuling Chen, Shouyi Wang, Yurong Yu, Ping Lu, Deyu Hu, Zaihui Yang
A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method for the simultaneous determination of spirotetramat and its four metabolite residues in citrus, peel, pulp and soil was developed and validated by liquid chromatography with tandem mass spectrometry (LC-MS/MS). The samples were extracted with acetonitrile (1%, glacial acetic acid, v/v) and purified using primary secondary amine and octadecylsilane. The limit of detection was 0.01-0.13 mg/kg, whereas that of quantification was 0.02-0...
November 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29168858/ferromagnetic-coupling-in-copper-benzimidazole-chloride-structural-mass-spectrometry-magnetism-and-dft-studies
#2
Xing-Xing Shi, Yuexing Zhang, Qiu-Jie Chen, Zheng Yin, Xue-Li Chen, Zhenxing Wang, Zhong-Wen Ouyang, Mohamedally Kurmoo, Ming-Hua Zeng
Herein, quasi-square planar Cu(II)(Hmbm)Cl2 (CBC, Hmbm = (1-methyl-1H-benzo[d]imidazol-2-yl)methanol) was arranged in a pseudo orthogonal way to form Cl-bridged chains, and further ππ interactions resulted in distorted hexagonal layers. DFT calculations reveal a bond strength order of Cu-Cl > Cu-O/N ≫ CuCl. ESI-MS data reveal several small fragments from CBC, but oligomeric [Cu], [Cu], and [Cu] for non-zero in-source energies; MS data indicates the occurrence of several chemical processes, viz. splitting of the ligand, oligomerization, and redox reaction of alcohol to aldehyde and Cu(II) to Cu(I)...
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29168710/a-soil-column-study-to-evaluate-treatment-of-trace-elements-from-saline-industrial-wastewater
#3
Jose M Paredez, Natalie Mladenov, Madhubhashini B Galkaduwa, Ganga M Hettiarachchi, Gerard J Kluitenberg, Stacy L Hutchinson
Industrial wastewater from the flue gas desulfurization (FGD) process is characterized by the presence of trace elements of concern, such as selenium (Se) and boron (B) and relatively high salinity. To simulate treatment that FGD wastewater undergoes during transport through soils in subsurface treatment systems, a column study (140-d duration) was conducted with native Kansas soil and saline FGD wastewater, containing high Se and B concentrations (170 μg/L Se and 5.3 mg/L B) and negligible arsenic (As) concentration (∼1...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29168193/the-effects-of-long-term-varenicline-administration-on-ethanol-and-sucrose-seeking-and-self-administration-in-male-p-rats
#4
Cristine L Czachowski, Janice C Froehlich, Michael DeLory
BACKGROUND: Varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic cholinergic receptors, is FDA approved for treatment of smoking cessation and has been found to reduce alcohol craving in clinical populations. In rodents, varenicline decreases free-choice ethanol intake with somewhat mixed findings in operant paradigms that utilize a combined appetitive/consummatory response. METHODS: The present experiment utilized an operant paradigm that procedurally separates appetitive from consummatory responding and a "reward blocking" approach (i...
November 23, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29168144/a-review-of-chronic-granulomatous-disease
#5
REVIEW
Danielle E Arnold, Jennifer R Heimall
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst in phagocytic leukocytes. Patients with CGD are at increased risk of life-threatening infections with catalase-positive bacteria and fungi and inflammatory complications such as CGD colitis. The implementation of routine antimicrobial prophylaxis and the advent of azole antifungals has considerably improved overall survival. Nevertheless, life expectancy remains decreased compared to the general population...
November 22, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29167936/potential-of-dynamically-harmonized-fourier-transform-ion-cyclotron-resonance-cell-for-high-throughput-metabolomics-fingerprinting-control-of-data-quality
#6
Baninia Habchi, Sandra Alves, Delphine Jouan-Rimbaud Bouveresse, Brice Appenzeller, Alain Paris, Douglas N Rutledge, Estelle Rathahao-Paris
Due to the presence of pollutants in the environment and food, the assessment of human exposure is required. This necessitates high-throughput approaches enabling large-scale analysis and, as a consequence, the use of high-performance analytical instruments to obtain highly informative metabolomic profiles. In this study, direct introduction mass spectrometry (DIMS) was performed using a Fourier transform ion cyclotron resonance (FT-ICR) instrument equipped with a dynamically harmonized cell. Data quality was evaluated based on mass resolving power (RP), mass measurement accuracy, and ion intensity drifts from the repeated injections of quality control sample (QC) along the analytical process...
November 22, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29167106/use-of-a-primary-care-online-consultation-system-by-whom-when-and-why-evaluation-of-a-pilot-observational-study-in-36-general-practices-in-south-west-england
#7
Hannah B Edwards, Elsa Marques, William Hollingworth, Jeremy Horwood, Michelle Farr, Elly Bernard, Chris Salisbury, Kate Northstone
OBJECTIVES: Evaluation of a pilot study of an online consultation system in primary care. We describe who used the system, when and why, and the National Health Service costs associated with its use. DESIGN: 15-month observational study. SETTING: Primary care practices in South West England. RESULTS: 36 General practices covering 396 828 patients took part in the pilot. The online consultation website was viewed 35 981 times over the pilot period (mean 9...
November 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29166845/identifying-the-minimum-number-of-microsatellite-loci-needed-to-assess-population-genetic-structure-a-case-study-in-fly-culturing
#8
Wolfgang Arthofer, Carina Heussler, Patrick Krapf, Birgit C Schlick-Steiner, Florian M Steiner
Small, isolated populations are constantly threatened by loss of genetic diversity due to drift. Such situations are found, for instance, in laboratory culturing. In guarding against diversity loss, monitoring of potential changes in population structure is paramount; this monitoring is most often achieved using microsatellite markers, which can be costly in terms of time and money when many loci are scored in large numbers of individuals. Here, we present a case study reducing the number of microsatellites to the minimum necessary to correctly detect the population structure of two Drosophila nigrosparsa populations...
November 23, 2017: Fly
https://www.readbyqxmd.com/read/29166416/limited-effect-of-cement-material-on-stress-distribution-of-a-monolithic-translucent-zirconia-crown-a-three-dimensional-finite-element-analysis
#9
Sebastian Franco-Tabares, Victoria Franke Stenport, Lars Hjalmarsson, Carina B Johansson
PURPOSE: The literature shows that the performance of densely sintered zirconia single crowns seems to be unaffected by the cement material. The purpose of this study was to evaluate the effects of various cement materials on the stress distribution in a monolithic translucent zirconia crown. MATERIALS AND METHODS: A crown-cement-dentin complex was modeled. Six cements were evaluated: zinc phosphate, glass-ionomer, resin-modified glass-ionomer, dual-cure resin, calcium aluminate-based, and a theoretical or conceptual cement with mechanical properties close to those of dentin (ie, monoblock cement)...
November 22, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29165455/isomer-specific-detection-in-the-uv-photodissociation-of-the-propargyl-radical-by-chirped-pulse-mm-wave-spectroscopy-in-a-pulsed-quasi-uniform-flow
#10
Bernadette M Broderick, Nicolas Suas-David, Nureshan Dias, Arthur G Suits
Isomer-specific detection and product branching fractions in the UV photodissociation of the propargyl radical is achieved through the use of chirped-pulse Fourier-transform mm-wave spectroscopy in a pulsed quasi-uniform flow (CPUF). Propargyl radicals are produced in the 193 nm photodissociation of 1,2-butadiene. Absorption of a second photon leads to H atom elimination giving three possible C3H2 isomers: singlets cyclopropenylidene (c-C3H2) and propadienylidene (l-C3H2), and triplet propargylene ((3)HCCCH)...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29164961/disability-and-activity-related-emotion-in-later-life-are-effects-buffered-by-intimate-relationship-support-and-strain
#11
Deborah Carr, Jennifer C Cornman, Vicki A Freedman
We use daily diary data from the Disability and Use of Time supplement to the 2013 Panel Study of Income Dynamics ( n = 1,162) to evaluate (1) the extent to which marital/partner support and strain moderate the effects of disability on five activity-related emotions (happiness, calm, sadness, frustration, worry) and overall negative and positive emotion among older married, cohabiting, and dating persons and (2) whether such patterns differ significantly by gender. Marital support buffers against negative emotions and increases feelings of calm among severely impaired women...
September 2017: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29164641/five-criteria-for-using-a-surrogate-endpoint-to-predict-treatment-effect-based-on-data-from-multiple-previous-trials
#12
Stuart G Baker
A surrogate endpoint in a randomized clinical trial is an endpoint that occurs after randomization and before the true, clinically meaningful, endpoint that yields conclusions about the effect of treatment on true endpoint. A surrogate endpoint can accelerate the evaluation of new treatments but at the risk of misleading conclusions. Therefore, criteria are needed for deciding whether to use a surrogate endpoint in a new trial. For the meta-analytic setting of multiple previous trials, each with the same pair of surrogate and true endpoints, this article formulates 5 criteria for using a surrogate endpoint in a new trial to predict the effect of treatment on the true endpoint in the new trial...
November 21, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29164639/analytic-energy-gradients-for-orbital-optimized-mp3-and-mp2-5-with-the-density-fitting-approximation-an-efficient-implementation
#13
Uğur Bozkaya
Efficient implementations of analytic gradients for the orbital-optimized MP3 and MP2.5 and their standard versions with the density-fitting approximation, which are denoted as DF-MP3, DF-MP2.5, DF-OMP3, and DF-OMP2.5, are presented. The DF-MP3, DF-MP2.5, DF-OMP3, and DF-OMP2.5 methods are applied to a set of alkanes and noncovalent interaction complexes to compare the computational cost with the conventional MP3, MP2.5, OMP3, and OMP2.5. Our results demonstrate that density-fitted perturbation theory (DF-MP) methods considered substantially reduce the computational cost compared to conventional MP methods...
November 21, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29164069/iron-acquisition-mechanisms-and-their-role-in-the-virulence-of-burkholderia-species
#14
REVIEW
Aaron T Butt, Mark S Thomas
Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly named species which can be found in a diverse range of environments. A number of pathogenic species occur within the genus. These include Burkholderia cenocepacia and Burkholderia multivorans, opportunistic pathogens that can infect the lungs of patients with cystic fibrosis, and are members of the Burkholderia cepacia complex (Bcc). Burkholderia pseudomallei is also an opportunistic pathogen, but in contrast to Bcc species it causes the tropical human disease melioidosis, while its close relative Burkholderia mallei is the causative agent of glanders in horses...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29163811/impaired-gabab-mediated-presynaptic-inhibition-increases-excitatory-strength-and-alters-short-term-plasticity-in-synapsin-knockout-mice
#15
Pierluigi Valente, Pasqualina Farisello, Flavia Valtorta, Pietro Baldelli, Fabio Benfenati
Synapsins are a family of synaptic vesicle phosphoproteins regulating synaptic transmission and plasticity. SYN1/2 genes are major epilepsy susceptibility genes in humans. Consistently, synapsin I/II/III triple knockout (TKO) mice are epileptic and exhibit severe impairments in phasic and tonic GABAergic inhibition that precede the appearance of the epileptic phenotype. These changes are associated with an increased strength of excitatory transmission that has never been mechanistically investigated. Here, we observed that an identical effect in excitatory transmission could be induced in wild-type (WT) Schaffer collateral-CA1 pyramidal cell synapses by blockade of GABAB receptors (GABABRs)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163463/selective-glucocorticoid-receptor-properties-of-gsk866-analogs-with-cysteine-reactive-warheads
#16
Chandra S Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W C Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand-binding strategies, classified as selective glucocorticoid receptor (GR) agonists (SEGRAs) or selective glucocorticoid receptor modulators (SEGRMs). In the current study, GSK866 analogs with electrophilic covalent-binding warheads were developed with potential SEGRA properties to improve their clinical safety profile for long-lasting topical skin disease applications...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163190/sr-bi-mediated-transcytosis-of-hdl-in-brain-microvascular-endothelial-cells-is-independent-of-caveolin-clathrin-and-pdzk1
#17
Karen Y Fung, Changsen Wang, Steffen Nyegaard, Bryan Heit, Gregory D Fairn, Warren L Lee
The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier. High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it difficult to elucidate its regulation. Using a combination of spinning-disc confocal and total internal reflection fluorescence microscopy, we examined the uptake and transcytosis of HDL by human primary brain microvascular endothelial cell monolayers...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163041/revisiting-the-quantum-brain-hypothesis-toward-quantum-neuro-biology
#18
Peter Jedlicka
The nervous system is a non-linear dynamical complex system with many feedback loops. A conventional wisdom is that in the brain the quantum fluctuations are self-averaging and thus functionally negligible. However, this intuition might be misleading in the case of non-linear complex systems. Because of an extreme sensitivity to initial conditions, in complex systems the microscopic fluctuations may be amplified and thereby affect the system's behavior. In this way quantum dynamics might influence neuronal computations...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29162809/full-scale-evaluation-of-methane-production-under-oxic-conditions-in-a-mesotrophic-lake
#19
D Donis, S Flury, A Stöckli, J E Spangenberg, D Vachon, D F McGinnis
Oxic lake surface waters are frequently oversaturated with methane (CH4). The contribution to the global CH4 cycle is significant, thus leading to an increasing number of studies and stimulating debates. Here we show, using a mass balance, on a temperate, mesotrophic lake, that ~90% of CH4 emissions to the atmosphere is due to CH4 produced within the oxic surface mixed layer (SML) during the stratified period, while the often observed CH4 maximum at the thermocline represents only a physically driven accumulation...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162424/injectable-hydrogels-for-localized-chemo-and-radio-therapy-in-brain-tumors
#20
Pilar de la Puente, Nicole Fettig, Micah J Luderer, Abbey Jin, Shruti Shah, Barbara Muz, Vaishali Kapoor, Sreekrishna M Goddu, Noha Nabil Salama, Christina Tsien, Dinesh Thotala, Kooresh Shoghi, Buck Rogers, Abdel Kareem Azab
PURPOSE: Overall survival of patients with newly diagnosed glioblastoma (GBM) remains dismal at 16 months with state-of-the-art treatment that includes surgical resection, radiation and chemotherapy. GBM tumors are highly heterogeneous and mechanisms for overcoming tumor resistance have not yet fully been elucidated. An injectable chitosan hydrogel capable of releasing chemotherapy (Temozolomide, TMZ) while retaining radioactive isotopes agents (Iodine, (131)I) was used as a vehicle for localized radiation and chemotherapy, within the surgical cavity...
November 18, 2017: Journal of Pharmaceutical Sciences
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