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https://www.readbyqxmd.com/read/29453681/-18-f-fpybf-2-a-new-f-18-labelled-amyloid-imaging-pet-tracer-biodistribution-and-radiation-dosimetry-assessment-of-first-in-man-18-f-fpybf-2-pet-imaging
#1
Ryuichi Nishii, Tatsuya Higashi, Shinya Kagawa, Chio Okuyama, Yoshihiko Kishibe, Masaaki Takahashi, Tomoko Okina, Norio Suzuki, Hiroshi Hasegawa, Yasuhiro Nagahama, Koichi Ishizu, Naoya Oishi, Hiroyuki Kimura, Hiroyuki Watanabe, Masahiro Ono, Hideo Saji, Hiroshi Yamauchi
OBJECTIVE: Recently, a benzofuran derivative for the imaging of β-amyloid plaques, 5-(5-(2-(2-(2- 18 F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- N-methylpyridin-2-amine ( 18 F-FPYBF-2) has been validated as a tracer for amyloid imaging and it was found that 18 F-FPYBF-2 PET/CT is a useful and reliable diagnostic tool for the evaluation of AD (Higashi et al. Ann Nucl Med, https://doi.org/10.1007/s12149-018-1236-1 , 2018). The aim of this study was to assess the biodistribution and radiation dosimetry of diagnostic dosages of 18 F-FPYBF-2 in normal healthy volunteers as a first-in-man study...
February 16, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29450565/tissue-distribution-of-gold-and-silver-after-subacute-intravenous-injection-of-co-administered-gold-and-silver-nanoparticles-of-similar-sizes
#2
Ji Hyun Lee, Jae Hyuck Sung, Hyun Ryol Ryu, Kyung Seuk Song, Nam Woong Song, Hyun Min Park, Beom Soo Shin, Kangho Ahn, Mary Gulumian, Elaine M Faustman, Il Je Yu
Gold (AuNPs, 12.8 nm) and silver nanoparticles (AgNPs, 10 nm), mixed or separate, were injected into the caudal vein of male Sprague-Dawley rats for 4 weeks. The rats were allowed to recover for further 4 weeks to examine the differences in AuNP/AgNP tissue distribution and clearance. The size distribution of injected AuNPs and AgNPs were not statistically different. The dose groups (five males per group for the administration and three males for the recovery) consisted of seven divisions, i.e., control, AgNPs (with a low dose of 10 µg/kg/day, and, a high dose of 100 µg/kg/day), AuNPs (with a low dose of 10 µg/kg/day, and, a high dose of 100 µg/kg/day), as well as mixed AgNPs/AuNPs (with a low dose of 10/10 µg/kg/day, and a high dose of 100/100 µg/kg/day)...
February 15, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29447967/fabrication-and-characterization-of-chitosan-conjugated-eurycomanone-nanoparticles-in-vivo-evaluation-of-the-biodistribution-and-toxicity-in-fish
#3
Irfan Ahmad Bhat, Mir Ishfaq Nazir, Irshad Ahmad, Gireesh-Babu Pathakota, T I Chanu, Mukunda Goswami, J K Sundaray, Rupam Sharma
Chitosan nanoparticles (CNPs) have been proven considerable delivery agents due to their remarkable physicochemical properties. Present study reports the fabrication of CNPs by ionic gelation process and their characterization by different approaches. The constructed nanoparticles were successfully conjugated with eurycomanone with significant entrapment efficiency. Particle size of chitosan and chitosan conjugated eurycomanone nanoparticles were 126.2 nm and 130 nm respectively. Scanning electron microscopy showed that the particles were spherical in shape and well dispersed...
February 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29447049/impact-of-acute-and-subchronic-inhalation-exposure-to-pbo-nanoparticles-on-mice
#4
J Lebedová, Z Nováková, Z Večeřa, M Buchtová, J Dumková, B Dočekal, L Bláhová, P Mikuška, I Míšek, A Hampl, K Hilscherová
Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72 h in acute experiment (4.05 × 10 6 PbO NPs/cm 3 ), and for 1-11 weeks in subchronic experiment (3...
February 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29444597/an-experimental-model-for-hypertensive-crises-emergencies-long-term-high-fat-diet-followed-by-acute-vasoconstriction-stress-on-spontaneously-hypertensive-rats
#5
Hong Liu, Wei-Wei Su, Chao-Feng Long, Wei-Jian Zhang, Pei-Bo Li, Zhong Wu, Yin-Yin Liao, Xuan Zeng, Tao-Bin Chen, Yu-Ying Zheng, Zeng-Hao Yan, Cong Bi, Hong-Liang Yao
Currently, the prevention and treatment of hypertensive crises especially when it occurs with serious adverse outcomes have led to worldwide controversy. Despite of clinical possibilities of multiple agents, clinical failures still occur frequently. Therefore, early evaluations and observations of different therapies on appropriate animals should be emphasized. In the present study, an animal model for hypertensive crises emergencies was firstly established and experimentally testified. Five-month-male spontaneously hypertensive rat was consecutively fed with 60%-Kcal fat diet for four, six, and eight weeks with body weight and blood pressure monitored every two weeks, and then followed by an acute vasoconstriction stress of 5-min ice-bath treatment in the 4-h time interval of two adrenaline injections (0...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29442908/systemic-toxicity-and-teratogenicity-of-copper-oxide-nanoparticles-and-copper-sulfate
#6
Ambika Vishnu Kadammattil, Shyama Prasad Sajankila, Suma Prabhu, Bhuvanagiri Nageshwar Rao, Bola Sadashiva Satish Rao
Acceleration in development of metallic nanoparticles for their utility in medical and technological applications due to their unique physicochemical properties has concurrently raised a matter of concern due to their potential toxicity. Of the enormous metallic nanostructures, copper oxide nanoparticles (CuONPs) having optical and electrochemical properties are scrutinized for theranostic applications. Therefore, their safety profile is of a major concern in optimizing a safe dose for its clinical utility...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442469/brain-death-associated-pathological-events-and-therapeutic-options
#7
REVIEW
Paweł Chudoba, Wojciech Krajewski, Joanna Wojciechowska, Dorota Kamińska
BACKGROUND: At present, organ transplantation is the most efficient treatment of end-stage failure of various organs, including the heart, lungs, pancreas, intestines, kidney, and liver. Despite the efforts to use organs from living donors or from donors after circulatory death, most of the organs are recovered from brain dead (BD) donors. METHODS: The Medline and Web of Science databases were searched without time limit on November 2015 using the terms "brain dead donor" and "deceased donor" in conjunction with "transplantation", "graft", "organ", "hemodynamic", "hormonal", or "management"...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29441989/modulated-function-of-multidrug-resistance-associated-proteins-in-cisplatin-induced-acute-renal-failure-rats
#8
A Matsushima, K Oda, N Mori, T Murakami
The effect of cisplatin-induced acute renal failure (ARF) on the function and expression of multidrug resistanceassociated proteins (MRPs) was evaluated in rats. Rats received an intraperitoneal injection of cisplatin (9 mg/kg), and the induction of ARF state with high plasma concentrations of indoxyl sulfate and creatinine was observed 72 h after cisplatin treatment. The function of MRPs in the liver, kidney and brain was evaluated by measuring the tissue accumulation and biliary excretion of 2,4-dintrophenyl-S-glutathione (DNP-SG), a substrate for MRPs, after administration of 1-chloro-2,4-dintrobenzene (CDNB), a precursor of DNP-SG, in rats...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29435413/the-e3-ubiquitin-ligase-murf2-attenuates-lps-induced-macrophage-activation-by-inhibiting-production-of-inflammatory-cytokines-and-migration
#9
Hongjun Bian, Shanshan Gao, Di Zhang, Qi Zhao, Feifei Li, Xiao Li, Shuohuan Sun, Shouyang Song, Tao Li, Qiang Zhu, Wanhua Ren, Chengyong Qin, Jianni Qi
Muscle RING-finger (MuRF) proteins are E3 ubiquitin ligases that are expressed in striated muscle. MuRF2 is an important member of this family, but whether it is expressed in tissues other than striated muscle has not been thoroughly elucidated to date. In this study, we determined that MuRF2 is also expressed in other vital organs, including liver, lung, brain, spleen and kidney. Moreover, we show that the level of MuRF2 expression is significantly decreased in hepatic mononuclear cells of mice with lipopolysaccharide (LPS)/d-galactosamine-induced hepatitis and negatively correlated with the serum levels of alanine aminotransferase and aspartate aminotransferase in these mice...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29433251/ethyl-acetate-fraction-from-hibiscus-sabdariffa-l-attenuates-diabetes-associated-cognitive-impairment-in-mice
#10
Tae Wan Seung, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Sang Hyun Park, Bong Seok Kwon, Chang Jun Lee, Jeong Eun Kang, Dae Ok Kim, Uk Lee, Ho Jin Heo
The ameliorating effects of the ethyl acetate fraction from Hibiscus sabdariffa L. (EFHS) 2 against diabetes mellitus (DM) 3 and DM-induced cognitive impairment were investigated on streptozotocin (STZ) 4 -induced DM mice. The EFHS groups showed improved hyperglycemia and glucose tolerance compared to the STZ group. Furthermore, their liver and kidney function and lipid metabolic imbalance in the blood serum were effectively recovered. The EFHS groups significantly ameliorated STZ-induced cognitive impairment in Y-maze, passive avoidance, and Morris water maze (MWM) 5 tests...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29427811/new-cytokines-and-tlr-pathway-signaling-molecules-in-chinese-rare-minnow-gobiocypris-rarus-molecular-characterization-basal-expression-and-their-response-to-chlorpyrifos
#11
Xu Zhao, Xiangsheng Hong, Rui Chen, Lilai Yuan, Jinmiao Zha, Jianhui Qin
In this study, the cDNA fragments of cytokines (il-8) and toll-like receptor (TLR) pathway signaling molecules (myd88, irak-1, irf5, and irf7) in the Chinese rare minnow were cloned and exhibited a high amino-acid sequence identity compared to other cyprinid fish orthologs. The mRNA expressions of these genes in the different tissues (liver, brain, spleen, kidney, and skin) were observed. The highest expression levels of myd88, irak-1, and irf5 were detected in the spleen, whereas il-8 and irf7 were detected in the kidney and liver respectively...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29427600/the-first-report-of-siglec-3-cd33-gene-in-a-teleost-rock-bream-oplegnathus-fasciatus-an-analysis-of-its-spatial-expression-during-stimulation-to-red-seabream-iridovirus-rsiv-and-two-bacterial-pathogens
#12
Joseph Jeswin, Min-Soo Joo, Ji-Min Jeong, Jin-Sol Bae, Kwang-Min Choi, Dong-Hee Cho, Son-Il Park, Chan-Il Park
Siglec-3/CD33 is a myeloid-specific inhibitory receptor that is expressed on cells of the immune system, where it is believed to play a regulatory role, modulating the inflammatory and immune responses. We characterized CD33 (RbCD33) in rock bream which is a transmembrane protein with two IG-like domains and a cytoplasmic tail. It has a deduced amino acid sequence of 390 residues and has tyrosine-based signaling motifs in the cytoplasmic tail. The RbCD33 mRNA was highly expressed in peripheral blood leukocytes and was also detected in the muscle, spleen, skin, head kidney, gills, trunk kidney, heart, stomach, brain, intestine and liver by quantitative real-time PCR...
February 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29424353/resuscitative-therapy-with-erythropoietin-reduces-oxidative-stress-and-inflammatory-responses-of-vital-organs-in-a-rat-severe-fixed-volume-hemorrhagic-shock-model
#13
Mina Ranjbaran, Mehri Kadkhodaee, Behjat Seifi, Reza Mirzaei, Parisa Ahghari
Hemorrhagic shock (HS) still has a high mortality rate and none of the known resuscitative regimens completely reverse its adverse outcomes. This study investigated the effects of different models of resuscitative therapy on the healing of organ damage in a HS model. Male Wistar rats were randomized into six groups: Sham, without HS induction; HS, without resuscitation; HS+Blood, resuscitation with the shed blood; HS+Blood+NS, resuscitation with blood and normal saline; HS+Blood+RL, resuscitation with blood and Ringer's lactate; EPO, erythropoietin was added to the blood and RL...
January 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29421328/the-effect-of-a-single-anti-vascular-endothelial-growth-factor-injection-on-neonatal-growth-and-organ-development-in-vivo-study
#14
Sina Khalili, Yulia Shifrin, Jingyi Pan, Jaques Belik, Kamiar Mireskandari
Retinopathy of prematurity (ROP) is one of the leading causes of blindness in preterm Infants. Anti-vascular endothelial growth factor (VEGF) is emerging as a promising treatment, but there is insufficient evidence on their safety. We investigate the effect of systemic anti-VEGF in rat pups with equivalent maturity to a 32 week neonate. A single dose of either anti-VEGF antibody (n = 7) or saline (control group; n = 6) was administered to newborn rats intra-peritoneally on the first day of life. 14 days' post treatment, the serum concentration of anti-VEGF was measured and the brain, lung, heart, kidney and liver were harvested and weighed...
January 31, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29414892/effects-of-phytochemical-p-glycoprotein-modulators-on-the-pharmacokinetics-and-tissue-distribution-of-doxorubicin-in-mice
#15
Tae Hwan Kim, Soyoung Shin, Sun Dong Yoo, Beom Soo Shin
Pungent spice constituents such as piperine, capsaicin and [6]-gingerol consumed via daily diet or traditional Chinese medicine, have been reported to possess various pharmacological activities. These dietary phytochemicals have also been reported to inhibit P-glycoprotein (P-gp) in vitro and act as an alternative to synthetic P-gp modulators. However, the in vivo effects on P-gp inhibition are currently unknown. This study aimed to test the hypothesis that phytochemical P-gp inhibitors, i.e., piperine, capsaicin and [6]-gingerol, modulate the in vivo tissue distribution of doxorubicin, a representative P-gp substrate...
February 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29406418/fructose-metabolism-and-noncommunicable-diseases-recent-findings-and-new-research-perspectives
#16
Luc Tappy
PURPOSE OF REVIEW: There is increasing concern that dietary fructose may contribute to the development of noncommunicable diseases. This review identifies major new findings related to fructose's physiological or adverse effects. RECENT FINDINGS: Fructose is mainly processed in splanchnic organs (gut, liver, kidneys) to glucose, lactate, and fatty acids, which can then be oxidized in extrasplanchnic organs and tissues. There is growing evidence that splanchnic lactate production, linked to extrasplanchnic lactate metabolism, represents a major fructose disposal pathway during and after exercise...
February 5, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29405939/neuromuscular-features-of-hypophosphatasia
#17
C Fonta, J-P Salles
The pathophysiology of the neuromuscular manifestations of hypophosphatasia (HPP) remains unknown. Pyridoxine-sensitive seizures characterize severe forms of infantile HPP. Young children and infants affected with severe forms of HPP, but also adults often present with myopathy characterized by hypotonia or muscle weakness. Chronic pain, of unclear mechanism is also often present. Tissue-non-specific alkaline phosphatase (Alkaline Phosphatase-Liver/Bone/Kidney [ALPL]) is expressed in brain neuronal cell and in muscle cells during development and adulthood...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29404855/an-evaluation-of-neurotoxicity-following-fluoride-exposure-from-gestational-through-adult-ages-in-long-evans-hooded-rats
#18
Christopher A McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S Brar, Ralph Wilson, Amy Brix, Catherine Picut, G Jean Harry
At elevated levels, fluoride (F-) exposure has been associated with adverse human health effects. In rodents, F- exposure has been reported to induce deficits in motor performance and learning and memory. In this study, we examined Long-Evans hooded male rats maintained on a standard diet (20.5 ppm F-) or a low F- diet (3.24 ppm F-) with drinking water exposure to 0, 10, or 20 ppm F- from gestational day 6 through adulthood. At postnatal day 25, brain F- levels were 0.048 or 0.081 μg/g and femur 235 or 379...
February 5, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29399682/the-antioxidant-2-6-di-tert-butylphenol-moiety-attenuates-the-pro-oxidant-properties-of-the-auranofin-analogue
#19
D B Shpakovsky, A A Shtil, E V Kharitonashvili, V Yu Tyurin, T A Antonenko, A A Nazarov, V P Osipova, N T Berberova, L S Foteeva, C Schmidt, I Ott, E R Milaeva
Metal-based drugs are gaining momentum as a rapidly developing area of medicinal inorganic chemistry. Among gold pharmaceuticals, auranofin is a well known antirheumatic drug. The efficacy of gold-organic complexes largely depends on their pro-oxidant properties since auranofin targets the redox enzyme thioredoxin reductase (TrxR). However, an uncontrollable oxygen burst may be harmful for healthy cells; therefore, the search for chemical modifications to attenuate oxidation-related general toxicity of gold containing anti-inflammatory drugs is justified...
February 5, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29398487/enzyme-replacement-therapy-ameliorates-multiple-symptoms-of-murine-homocystinuria
#20
Tomas Majtan, Wendell Jones, Jakub Krijt, Insun Park, Warren D Kruger, Viktor Kožich, Steven Bassnett, Erez M Bublil, Jan P Kraus
Classical homocystinuria (HCU) is the most common inherited disorder of sulfur amino acid metabolism caused by deficiency in cystathionine beta-synthase (CBS) activity and characterized by severe elevation of homocysteine in blood and tissues. Treatment with dietary methionine restriction is not optimal, and poor compliance leads to serious complications. We developed an enzyme replacement therapy (ERT) and studied its efficacy in a severe form of HCU in mouse (the I278T model). Treatment was initiated before or after the onset of clinical symptoms in an effort to prevent or reverse the phenotype...
December 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
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