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https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#1
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29667120/chromium-in-postmortem-material
#2
Danuta Dudek-Adamska, Teresa Lech, Tomasz Konopka, Paweł Kościelniak
Recently, considerable attention has been paid to the negative effects caused by the presence and constant increase in concentration of heavy metals in the environment, as well as to the determination of their content in human biological samples. In this paper, the concentration of chromium in samples of blood and internal organs collected at autopsy from 21 female and 39 male non-occupationally exposed subjects is presented. Elemental analysis was carried out by an electrothermal atomic absorption spectrometer after microwave-assisted acid digestion...
April 17, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29663031/urea-and-plasma-ice-nucleating-proteins-promoted-the-modest-freeze-tolerance-in-pleske-s-high-altitude-frog-nanorana-pleskei
#3
Yonggang Niu, Jianjun Wang, Shengkang Men, Yaofeng Zhao, Songsong Lu, Xiaolong Tang, Qiang Chen
The frog Nanorana pleskei (Dicroglossidae) is indigenous to the Qinghai-Tibetan Plateau. To identify its strategies in coping with the cold climate, we measured the hibernacula microhabitat temperature during winter. We also examined the freezing-induced and seasonal variation of several putative cryoprotectants in the heart, liver, brain, kidney and muscle, as well as ice-nucleating protein in plasma. Our results showed that N. pleskei survived exposure to temperatures as low as - 2.5 ± 0.40 °C during hibernation, which was lower than the body fluid freezing point (- 0...
April 16, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29660343/transcription-of-blunt-snout-bream-megalobrama-amblycephala-hif3%C3%AE-and-its-localization-in-the-nucleus-under-both-normoxic-and-hypoxic-conditions
#4
Ziyin Liu, Xinyu Zhao, Xiayun Jiang, Shuming Zou
Although hypoxia-inducible factor (HIF) 1α and 2α function as master regulators of the transcriptional response to hypoxia, the function of HIF3α and its responses to hypoxic stress remain unclear in teleost fish. Here, we characterized the HIF3α cDNA in hypoxia-sensitive blunt snout bream (Megalobrama amblycephala), with 3059 bp length, consisting of an open reading frame (ORF) encoding 643 amino acid residues. Blunt snout bream HIF3α mRNA was stably expressed during stages of embryonic development and in adult tissues...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29660307/gonadotropin-receptors-of-labeo-rohita-cloning-and-characterization-of-full-length-cdnas-and-their-expression-analysis-during-annual-reproductive-cycle
#5
Avinash Pradhan, Madhusmita Nayak, Mrinal Samanta, Rudra Prasanna Panda, Suresh Chandra Rath, Shiba Shankar Giri, Ashis Saha
Follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh), secreted from pituitary, stimulate gonadal function by binding to their cognate receptors FSH receptor (FSHR), and LH/ choriogonadotropin receptor (LHCGR). Rohu (Labeo rohita) is a commercially important seasonal breeder freshwater fish species, but till date, the regulation of expression of gonadotropins and their receptors gene during different phases of annual reproductive cycle has not been investigated. We envisaged the critical role of these molecules during seasonal gonadal development in this carp species...
April 13, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29660237/multiplexed-isobaric-tag-based-profiling-of-seven-murine-tissues-following-in-vivo-nicotine-treatment-using-a-minimalistic-proteomics-strategy
#6
Joao A Paulo, Mark P Jedrychowski, Edward T Chouchani, Lawrence Kazak, Steven P Gygi
Nicotine is a major addictive compound in tobacco and a component of smoking-related products, such as e-cigarettes. Once internalized, nicotine can perturb many cellular pathways and can induce alterations in proteins across different cell types, however the mechanisms thereof remain undetermined. We hypothesize that both tissue-specific and global protein abundance alterations result from nicotine exposure. As such, we present the first proteome analysis of multiple tissues from nicotine-exposed mice. We treat mice via oral administration of nicotine at 200μg/mL in drinking water for 21 days...
April 16, 2018: Proteomics
https://www.readbyqxmd.com/read/29655944/regular-aerobic-exercise-correlates-with-reduced-anxiety-and-incresed-levels-of-irisin-in-brain-and-white-adipose-tissue
#7
Nazan Uysal, Oguz Yuksel, Servet Kizildag, Zeynep Yuce, Hikmet Gumus, Aslı Karakilic, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates
We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. Irisin is an exercise-induced myokine that is produced by many tissues; and the role it plays in anxiolytic behavior is unknown. In this study we aimed to investigate the correlation between anxiety like behavior and irisin levels following regular voluntary aerobic exercise in male mice. We've have shown that anxiety levels decreased in exercised mice, while irisin levels increased in the brain, brown adipose tissue, white adipose tissue, kidney, and pancreas tissues...
April 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29655871/cloning-partial-sequencing-and-expression-analysis-of-the-neural-form-of-p450-aromatase-cyp19a1b-in-the-south-america-catfish-rhamdia-quelen
#8
Helena C Silva de Assis, Laia Navarro-Martín, Letícia S P Fernandes, Cibele C Cardoso, Daniela Parada Pavoni, Vance L Trudeau
Brain aromatase is a key enzyme exclusively expressed in fish radial glial cells that convert androgens into estrogens, thus controlling neuroendocrine functions and neurogenesis. As an important step in characterizing the neuroendocrine systems of Rhamdia quelen (jundiá), a partial cDNA sequence (1045 bp) of brain aromatase (cyp19a1b) was cloned and sequenced. At the nucleotide level the cDNA sequence was found to be 88% identical to cyp19a1b of two species of catfish, Ictalurus punctatus and Silurus meridionalis...
April 12, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29643716/brain-metastasis-from-renal-urothelial-carcinoma-successfully-treated-by-metastasectomy
#9
Wen-Kuei Fang, Yeong-Chin Jou, Yuan-Chang Dai, Pi-Chan Ko, Ya-Fang Huang
Upper tract urothelial cancer (UTUC) arises from the urothelial lining of the urinary tract. UTUC spreads in several different ways including direct invasion, lymphatic spread, and hematogeneous metastases. Regional lymph nodes are commonly the initial site of metastasis, followed by the liver, lung, and bone. Brain metastasis is uncommon in patients with urothelial carcinoma. Here, we report an uncommon case of kidney urothelial carcinoma with brain metastasis in a 55-year-old woman presenting with dysarthria with right side limb weakness...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29642674/expression-of-prohibitin-f-actin-capping-protein-subunit-beta-and-tektin-2-gene-in-murrah-buffalo-sperm-and-its-relationship-with-sperm-motility
#10
Deshun Shi, Xiangping Li, Zhaocheng Xiong, Haihang Zhang, Ben Huang, Qingyou Liu, Yingqun Wang
Objective: The aim of the current study is to investigate the relationship between PHB, CAPZB, and TEKT2 and sperm motility in Murrah buffalo. Methods: We collected the high-motility and low-motility semen samples, testis, ovary, muscle, kidney, liver, brain and pituitary from Murrah buffalo, and analysed the expression of PHB, CAPZB and TEKT2 in mRNA (message RNA) and protein level. Results: QRT-PCR (Quantitative Reverse Transcription-PCR) result showed that the expression of PHB was higher and CAPZB, TEKT2 were specifically expressed in testis as compared to the other 6 tissues, and that in testis, the expression of TEKT2 was higher than that of CAPZB and PHB...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29628017/snail-borne-parasitic-diseases-an-update-on-global-epidemiological-distribution-transmission-interruption-and-control-methods
#11
REVIEW
Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
BACKGROUND: Snail-borne parasitic diseases, such as angiostrongyliasis, clonorchiasis, fascioliasis, fasciolopsiasis, opisthorchiasis, paragonimiasis and schistosomiasis, pose risks to human health and cause major socioeconomic problems in many tropical and sub-tropical countries. In this review we summarize the core roles of snails in the life cycles of the parasites they host, their clinical manifestations and disease distributions, as well as snail control methods. MAIN BODY: Snails have four roles in the life cycles of the parasites they host: as an intermediate host infected by the first-stage larvae, as the only intermediate host infected by miracidia, as the first intermediate host that ingests the parasite eggs are ingested, and as the first intermediate host penetrated by miracidia with or without the second intermediate host being an aquatic animal...
April 9, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29627477/distribution-of-mannose-receptor-in-blunt-snout-bream-megalobrama-amblycephala-during-the-embryonic-development-and-its-immune-response-to-the-challenge-of-aeromonas-hydrophila
#12
Changsong Wu, Xiaoheng Zhao, Sarath Babu V, Gailing Yuan, Weimin Wang, Jianguo Su, Xiaoling Liu, Li Lin
The mannose receptor (MR) is a type I transmembrane protein. Its ectodomain has eight C-type lectin-like domains, which are able to recognize and mediate the phagocytosis of a wide range of pathogens. Comprehensive studies have revealed that mammalian MR is widely distributed in the mononuclear phagocyte system (MPS, previously known as the reticuloendothelial system) and play a key role both in the physiological clearance and cell activation. Hitherto, neither the MR distribution, nor the function of clearance and cell activation has been investigated in fish...
April 6, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29626439/regulation-of-dichloroacetate-biotransformation-in-rat-liver-and-extrahepatic-tissues-by-gstz1-expression-and-chloride-concentration
#13
Stephan C Jahn, Marci G Smeltz, Zhiwei Hu, Laura Rowland-Faux, Guo Zhong, Ryan J Lorenzo, Katherine V Cisneros, Peter W Stacpoole, Margaret O James
Biotransformation of dichloroacetate (DCA) to glyoxylate by hepatic glutathione transferase zeta 1 (GSTZ1) is considered the principal determinant of the rate of plasma clearance of the drug. However, several other organismal and subcellular factors are also known to influence DCA metabolism. We utilized a female rat model to study these poorly understood processes. Rats aged 4 weeks (young) and 42 to 52 weeks (adult) were used to model children and adults, respectively. Hepatic chloride concentrations, which influence the rate of GSTZ1 inactivation by DCA, were lower in rat than in human tissues and rats did not show the age dependence previously seen in humans...
April 4, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29625385/targeting-macrophage-immunometabolism-dawn-in-the-darkness-of-sepsis
#14
REVIEW
V Kumar
Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates. Advancement in modern medicine and establishment of separate branches of medical science dealing with sepsis research have improved its outcome. However, mortality associated with sepsis still remains higher (25-30%) that further increases to 40-50% in the presence of septic shock. For example, sepsis-associated deaths account more in comparison to deaths-associated with myocardial-infarction and certain cancers (i.e. breast and colorectal cancer)...
April 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29624380/rapid-in-situ-profiling-of-lipid-c-c-location-isomers-in-tissue-using-ambient-mass-spectrometry-with-photochemical-reactions
#15
Fei Tang, Chengan Guo, Xiaoxiao Ma, Jian Zhang, Yuan Su, Ran Tian, Riyi Shi, Yu Xia, Xiaohao Wang, Zheng Ouyang
Rapid and in situ profiling of lipids using ambient mass spectrometry (AMS) techniques has great potential for clinical diagnosis, biological studies and biomarker discovery. In this study, the online photochemical reaction involving carbon-carbon double bonds, was coupled with a surface sampling technique to develop a direct tissue analysis method with specificity to lipid C=C isomers. This method enabled the in situ analysis of lipids from the surface of various tissues or tissue sections, which allowed the structural characterization of lipid isomers within 2 minutes...
April 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29623826/targeting-ampk-in-diabetes-and-diabetic-complications-energy-homeostasis-autophagy-and-mitochondrial-health
#16
Y V Madhavi, Nikhil Gaikwad, Veera Ganesh Yerra, Anil Kumar Kalvala, Srinivas Nanduri, Ashutosh Kumar
Adenosine 5'-monophosphate activated protein kinase (AMPK) is a key enzymatic protein involved in linking the energy sensing to the metabolic manipulation. It is a serine/threonine kinase activated by several upstream kinases. AMPK is a heterotrimeric protein complex regulated by AMP, ADP, and ATP allosterically. AMPK is ubiquitously expressed in various tissues of the living system such as heart, kidney, liver, brain and skeletal muscles. Thus malfunctioning of AMPK is expected to harbor several human pathologies especially diseases associated with metabolic and mitochondrial dysfunction...
April 6, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29616363/a-comparative-in-vivo-scrutiny-of-biosynthesized-copper-and-zinc-oxide-nanoparticles-by-intraperitoneal-and-intravenous-administration-routes-in-rats
#17
Ashajyothi C, Harish K Handral, Chandrakanth Kelmani R
During the present time, anti-microbial features of copper (Cu) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used to combat the growth of pathogenic microbes. CuNPs and ZnONPs are recurrently used in cosmetics, medicine and food additives, and their potential for toxic impacts on human and ecosystem is of high concern. In this study, the fate and toxicity of 16- to 96-nm-ranged biosynthesized copper (Bio-CuNPs) and zinc oxide (Bio-ZnONPs) was assessed in male Wistar rats. In vivo exposures of the two nanoparticles are achieved through two different administration routes namely, intraperitoneal (i/p) and intravenous (i/v) injections...
April 3, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29616223/geraniin-protects-high-fat-diet-induced-oxidative-stress-in-sprague-dawley-rats
#18
Alexis Panny Y S Chung, Sunil Gurtu, Srikumar Chakravarthi, Mohanambal Moorthy, Uma D Palanisamy
Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro and recently been recognized for its therapeutic potential in metabolic syndrome. This study investigated its antioxidative strength and protective effects on organs in high-fat diet (HFD)-induced rodents. Rats were fed HFD for 6 weeks to induce obesity, followed by 10 and 50 mg/kg of geraniin supplementation for 4 weeks to assess its protective potential...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29616081/insertion-deletion-within-the-kdm6a-gene-is-significantly-associated-with-litter-size-in-goat
#19
Yang Cui, Hailong Yan, Ke Wang, Han Xu, Xuelian Zhang, Haijing Zhu, Jinwang Liu, Lei Qu, Xianyong Lan, Chuanying Pan
A previous whole-genome association analysis identified lysine demethylase 6A ( KDM6A ), which encodes a type of histone demethylase, as a candidate gene associated to goat fecundity. KDM6A gene knockout mouse disrupts gametophyte development, suggesting that it has a critical role in reproduction. In this study, goat KDM6A mRNA expression profiles were determined, insertion/deletion (indel) variants in the gene identified, indel variants effect on KDM6A gene expression assessed, and their association with first-born litter size analyzed in 2326 healthy female Shaanbei white cashmere goats...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29605768/perinatal-exposure-to-energy-drink-induces-oxidative-damage-in-the-liver-kidney-and-brain-and-behavioral-alterations-in-mice-offspring
#20
Gadh I Al-Basher, Hanan Aljabal, Rafa S Almeer, Ahmed A Allam, Ayman M Mahmoud
The worldwide consumption of energy drinks (EDs) has increased in recent years. EDs have several side effects and can be linked to liver injury, kidney damage and risk-seeking behavior. The impact of perinatal consumption of EDs on the newborns has not been previously investigated. In this study, we evaluated the effects of perinatal exposure to a caffeinated ED on the liver, kidney, brain, locomotor activity and anxiety in mice newborns. Pregnant mice received 2.5 or 5 ml ED by oral gavage from the first day of pregnancy until day 15 after birth...
March 29, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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