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https://www.readbyqxmd.com/read/28433640/partial-gland-treatment-of-prostate-cancer-utilizing-high-intensity-focused-ultrasound-in-the-primary-and-salvage-setting-a-systematic-review
#1
REVIEW
Ron Golan, Adrien N Bernstein, Timothy D McClure, Art Sedrakyan, Neal A Patel, Dipen J Parekh, Leonard S Marks, Jim C Hu
PURPOSE: Advances in prostate imaging, biopsy and ablative technologies have been accompanied by growing enthusiasm for partial gland ablation, particularly using high-intensity focused ultrasound (HIFU) for treating prostate cancer. The preservation of non-cancerous prostate tissue and minimizing damage to the neurovascular bundles and external urethral sphincter may improve functional outcomes. MATERIALS AND METHODS: A systematic review was performed following the PRISMA guidelines using a combination of MeSH terms, free-text search, and review of relevant bibliographies using Medline and Embase from the inception of each database through October 10, 2016...
April 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28413336/a-restatement-of-the-natural-science-evidence-concerning-catchment-based-natural-flood-management-in-the-uk
#2
REVIEW
Simon J Dadson, Jim W Hall, Anna Murgatroyd, Mike Acreman, Paul Bates, Keith Beven, Louise Heathwaite, Joseph Holden, Ian P Holman, Stuart N Lane, Enda O'Connell, Edmund Penning-Rowsell, Nick Reynard, David Sear, Colin Thorne, Rob Wilby
Flooding is a very costly natural hazard in the UK and is expected to increase further under future climate change scenarios. Flood defences are commonly deployed to protect communities and property from flooding, but in recent years flood management policy has looked towards solutions that seek to mitigate flood risk at flood-prone sites through targeted interventions throughout the catchment, sometimes using techniques which involve working with natural processes. This paper describes a project to provide a succinct summary of the natural science evidence base concerning the effectiveness of catchment-based 'natural' flood management in the UK...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28411494/fibroblast-growth-factor-23-as-a-predictor-of-cardiovascular-and-all-cause-mortality-in-prospective-studies
#3
Zhexue Qin, Xi Liu, Mingbao Song, Quan Zhou, Jie Yu, Baoshang Zhou, Yazhou Wu, Yongming He, Lan Huang
BACKGROUND AND AIMS: The prognostic value of fibroblast growth factor 23 (FGF23) for mortality remains controversial. We performed a meta-analysis of cohort studies to examine the controversial relationship between FGF23 and mortality. METHODS: PubMed, EMBASE, the Cochrane Library databases and reference bibliographies were searched through September 2016 to identify prospective cohort studies with relative risks (RRs) and 95% confidence intervals (CIs) for FGF23 and mortality...
April 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28406324/evolving-paradigm-of-treatment-for-autoimmune-hepatitis
#4
Albert J Czaja
Current medications for autoimmune hepatitis have broad anti-inflammatory and immunosuppressive actions, and their effects are short-lived and inconsistent. The goals of this review were to describe the actions and shortcomings of these medications, indicate the key pathogenic mechanisms that might be targeted by site-directed interventions, and present the pivotal studies supporting development of these alternative agents. Areas covered: Abstracts cited in PubMed from April 1964 to February 2017 were identified using the search words "treatment of autoimmune hepatitis"...
April 13, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28403263/microneedling-in-all-skin-types-a-review
#5
Lauren Meshkov Bonati, Gorana Kuka Epstein, Tamara Lazic Strugar
<p>INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.</p> <p>METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Search terms included: "microneedling," "percutaneous collagen induction," "needling," "skin needling," and "dermaroller...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28395551/use-of-tigecycline-in-pediatric-clinical-practice
#6
Maria Vincenza Mastrolia, Luisa Galli, Maurizio de Martino, Elena Chiappini
INTRODUCTION: Tigecycline, a derivative of minocycline, is an extended-spectrum antimicrobial agent. It has a restricted approval field in children and the experience of its adoption in clinical practice is reserved for cases of challenging infections. The aim of this review was to summarize evidence regarding the use of tigecycline in infants and children, focusing on the drug's clinical efficacy data and tolerability profile. AREAS COVERED: We have conducted a literature search of the Cochrane Library, EMBASE, and MEDLINE databases, from their inception through January 5, 2017, using the following terms: tigecycline, newborn, infant, child, pediatrics, adolescent, human, clinical trial, and case report...
April 11, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28392927/liraglutide-for-weight-management-a-critical-review-of-the-evidence
#7
A Mehta, S P Marso, I J Neeland
OBJECTIVE: To review the efficacy, safety, and clinical applicability of liraglutide for weight management from phase III clinical trials. METHODS: A search of the English language literature was performed using PubMed search terms: "liraglutide", "glucagon-like peptide-1 receptor agonist", and "randomized clinical trial". Articles and bibliographies relevant to the subject were reviewed and additional references known to the authors were included. RESULTS: Five randomized, placebo-controlled trials of liraglutide for weight management were identified...
March 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28385495/dosimetric-characterization-of-small-fields-using-a-plastic-scintillator-detector-a-large-multicenter-study
#8
Pietro Mancosu, Massimo Pasquino, Giacomo Reggiori, Laura Masi, Serenella Russo, Michele Stasi
PURPOSE: In modern radiation therapy accurate small fields dosimetry is a challenge and its standardization is fundamental to harmonize delivered dose in different institutions. This study presents a multicenter characterization of MLC-defined small field for Elekta and Varian linear accelerators. Measurements were performed using the Exradin W1 plastic scintillator detector. MATERIALS AND METHODS: The project enrolled 24 Italian centers. Each center performed Tissue Phantom Ratio (TPR), in-plane and cross-plane dose profiles of 0...
April 3, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28375448/alginate-therapy-is-effective-treatment-for-gerd-symptoms-a-systematic-review-and-meta-analysis
#9
D A Leiman, B P Riff, S Morgan, D C Metz, G W Falk, B French, C A Umscheid, J D Lewis
In patients with gastroesophageal reflux disease (GERD) and erosive esophagitis, treatment with proton pump inhibitors (PPIs) is highly effective. However, in some patients, especially those with nonerosive reflux disease or atypical GERD symptoms, acid-suppressive therapy with PPIs is not as successful. Alginates are medications that work through an alternative mechanism by displacing the postprandial gastric acid pocket. This study performed a systematic review and meta-analysis to examine the benefit of alginate-containing compounds in the treatment of patients with symptoms of GERD...
May 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28373906/a-meta-analysis-of-palliative-treatment-of-pancreatic-cancer-with-high-intensity-focused-ultrasound
#10
Susan Dababou, Cristina Marrocchio, Jarrett Rosenberg, Rachelle Bitton, Kim Butts Pauly, Alessandro Napoli, Joo Ha Hwang, Pejman Ghanouni
BACKGROUND: Pancreatic adenocarcinoma is currently the fourth-leading cause of cancer-related death. Up to 60-90% of patients with advanced disease suffer cancer-related pain, severely impacting their quality of life. Current management involves primarily pharmacotherapy with opioid narcotics and celiac plexus neurolysis; unfortunately, both approaches offer transient relief and cause undesired side-effects. High intensity focused ultrasound (HIFU) is a non-invasive thermal ablation technique that has been used to treat pancreatic cancer...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28369602/statins-and-secondary-prevention-of-venous-thromboembolism-pooled-analysis-of-published-observational-cohort-studies
#11
Setor K Kunutsor, Samuel Seidu, Kamlesh Khunti
Aims: There have been suggestions that statins may have a potential role in secondary prevention of venous thromboembolism (VTE) [which includes deep vein thrombosis (DVT) and pulmonary embolism (PE)], but the evidence is inconsistent. We aimed to evaluate the association between statin use and risk of recurrent VTE. Methods and results: We conducted a systematic review and meta-analysis of observational cohort studies. All relevant studies which reported associations between statin use and recurrent VTE outcomes were identified from MEDLINE, EMBASE, Web of Science, and manual search of bibliographies from inception to January 2017...
March 22, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28364306/-antipyretics-in-intensive-care-patients
#12
A Simon, A Leffler
BACKGROUND: Antipyretics are among the most widely prescribed drugs in German hospitals. Despite this widespread use, their role for treatment of critically ill patients still remains unclear. In particular, the questionable positive effects of reducing fever are discussed. OBJECTIVES: In this review we aimed to summarize and discuss current study results covering the use of antipyretics in critically ill patients. Suspected effects with regard to fever reduction and lethality should be considered...
March 31, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28360239/instruments-measuring-the-disease-specific-quality-of-life-of-family-carers-of-people-with-neurodegenerative-diseases-a-systematic-review
#13
Thomas E Page, Nicolas Farina, Anna Brown, Stephanie Daley, Ann Bowling, Thurstine Basset, Gill Livingston, Martin Knapp, Joanna Murray, Sube Banerjee
OBJECTIVE: Neurodegenerative diseases, such as dementia, have a profound impact on those with the conditions and their family carers. Consequently, the accurate measurement of family carers' quality of life (QOL) is important. Generic measures may miss key elements of the impact of these conditions, so using disease-specific instruments has been advocated. This systematic review aimed to identify and examine the psychometric properties of disease-specific outcome measures of QOL of family carers of people with neurodegenerative diseases (Alzheimer's disease and other dementias; Huntington's disease; Parkinson's disease; multiple sclerosis; and motor neuron disease)...
March 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28355432/primary-prevention-implantable-cardioverter-defibillators-in-patients-with-nonischemic-cardiomyopathy-a-meta-analysis
#14
Sana M Al-Khatib, Gregg C Fonarow, Jose A Joglar, Lurdes Y T Inoue, Daniel B Mark, Kerry L Lee, Alan Kadish, Gust Bardy, Gillian D Sanders
Importance: Conflicting data have emerged on the efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention of sudden cardiac death (primary prevention ICDs) in patients with nonischemic cardiomyopathy. Objective: To investigate the association of primary prevention ICDs with all-cause mortality in patients with nonischemic cardiomyopathy. Data Sources: PubMed was searched from January 1, 2000, through October 31, 2016, for the terms implantable defibrillator OR implantable cardioverter defibrillator AND non-ischemic cardiomyopathy...
March 29, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28351167/talimogene-laherparepvec
#15
Patricia A Corrigan, Caroline Beaulieu, Rashmi B Patel, Denise K Lowe
OBJECTIVE: To review the efficacy and safety of talimogene laherparepvec (T-VEC) as well as its pharmacology, pharmacokinetics, drug-drug interactions, handling procedures, cost considerations, and place in therapy. DATA SOURCES: Searches of PubMed (1966 to February 2017) and Cochrane Library (1999 to February 2017) were conducted using the terms talimogene laherparepvec, T-VEC, OncoVEX, immunotherapy, melanoma, and oncolytic virus. Additional information was determined from bibliographies, manufacturer product labeling and website, meeting abstracts, Food and Drug Administration website, and clinicaltrials...
March 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28350315/death-during-simulation-a-literature-review
#16
Benjamin J Heller, Samuel DeMaria, Daniel Katz, Joshua A Heller, Andrew T Goldberg
INTRODUCTION: One of the goals of simulation is to teach subjects critical skills and knowledge applicable to live encounters, without the risk of harming actual patients. Although simulation education has surged in medical training over the last two decades, several ethically challenging educational methods have arisen. Simulated death has arisen as one of these challenging issues and currently there is no consensus regarding how to best manage this controversial topic in the simulated environment...
October 2016: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28349514/l-carnitine-for-cognitive-enhancement-in-people-without-cognitive-impairment
#17
REVIEW
Ning Chen, Mi Yang, Muke Zhou, Jing Xiao, Jian Guo, Li He
BACKGROUND: Safe interventions to enhance cognitive function in cognitively healthy people would be very valuable for several reasons, including a better quality of life and professional success. While L-carnitine has been reported to enhance cognitive function in some conditions, its efficacy is disputed. The evidence of its efficacy for cognitively healthy people has not previously been systematically reviewed. OBJECTIVES: To assess the efficacy and safety of L-carnitine for the enhancement of cognitive function in people without cognitive impairment...
March 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28344641/litdb-keeping-track-of-research-papers-from-your-institute-made-simple
#18
Jörn Bethune, Lars Kraemer, Ingo Thomsen, Andreas Keller, David Ellinghaus, Andre Franke
BACKGROUND: In science peer-reviewed publications serve as an important indicator of scientific excellence and productivity. Therefore, every scientist and institution must carefully maintain and update records of their scientific publications. However, in most institutions and universities articles are often managed in a redundant file-based and non-central way. Whereas excellent reference management software packages such as Zotero, Endnote or Mendeley exist to manage bibliographies and references when writing scientific articles, we are not aware of any open source database solution keeping track of publication records from large scientific groups, entire institutions and/or universities...
2017: Source Code for Biology and Medicine
https://www.readbyqxmd.com/read/28344521/timing-of-debridement-and-infection-rates-in-open-fractures-of-the-hand-a-systematic-review
#19
REVIEW
Constantinos Ketonis, Joseph Dwyer, Asif M Ilyas
Background: Literature on open fracture infections has focused primarily on long bones, with limited guidelines available for open hand fractures. In this study, we systematically review the available hand surgery literature to determine infection rates and the effect of debridement timing and antibiotic administration. Methods: Searches of the MEDLINE, EMBASE, and Cochrane computerized literature databases and manual bibliography searches were performed. Descriptive/quantitative data were extracted, and a meta-analysis of different patient cohorts and treatment modalities was performed to compare infection rates...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28344326/mutual-information-model-for-link-prediction-in-heterogeneous-complex-networks
#20
Hadi Shakibian, Nasrollah Moghadam Charkari
Recently, a number of meta-path based similarity indices like PathSim, HeteSim, and random walk have been proposed for link prediction in heterogeneous complex networks. However, these indices suffer from two major drawbacks. Firstly, they are primarily dependent on the connectivity degrees of node pairs without considering the further information provided by the given meta-path. Secondly, most of them are required to use a single and usually symmetric meta-path in advance. Hence, employing a set of different meta-paths is not straightforward...
March 27, 2017: Scientific Reports
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