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https://www.readbyqxmd.com/read/28237807/effects-of-paclitaxel-on-the-development-of-neuropathy-and-affective-behaviors-in-the-mouse
#1
Wisam Toma, S Lauren Kyte, Deniz Bagdas, Yasmin Alkhlaif, Shakir D Alsharari, Aron H Lichtman, Zhi-Jian Chen, Egidio Del Fabbro, John W Bigbee, David A Gewirtz, M Imad Damaj
Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer patients. However, paclitaxel and other chemotherapy drugs elicit peripheral nerve fiber dysfunction or degeneration that leads to peripheral neuropathy in a large proportion of cancer patients. Patients receiving chemotherapy also often experience changes in mood, including anxiety and depression. These somatic and affective disorders represent major dose-limiting side effects of chemotherapy...
February 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28235835/explaining-socioeconomic-inequalities-in-exclusive-breast-feeding-in-norway
#2
Anne Bærug, Petter Laake, Beate Fossum Løland, Thorkild Tylleskär, Elisabeth Tufte, Atle Fretheim
BACKGROUND AND OBJECTIVE: In high-income countries, lower socioeconomic position is associated with lower rates of breast feeding, but it is unclear what factors explain this inequality. Our objective was to examine the association between socioeconomic position and exclusive breast feeding, and to explore whether socioeconomic inequality in exclusive breast feeding could be explained by other sociodemographic characteristics, for example, maternal age and parity, smoking habits, birth characteristics, quality of counselling and breastfeeding difficulties...
February 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28235833/early-life-exposures-predicting-onset-and-resolution-of-childhood-overweight-or-obesity
#3
Jessica A Kerr, Catherine Long, Susan A Clifford, Joshua Muller, Alanna N Gillespie, Susan Donath, Melissa Wake
OBJECTIVES: To determine which of multiple early-life exposures predict onset or resolution of overweight/obesity during a 9-year period. METHODS: Design: longitudinal cohort from three harmonised community-based cohorts enriched for overweight and obesity. Early-life exposures: child-gestational age; delivery; birth weight; breast feeding; solids introduction; baseline body mass index (BMI); waist circumference; diet; activity; global, physical and psychosocial health...
February 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28219238/public-health-risk-of-arsenic-species-in-chicken-tissues-from-live-poultry-markets-of-guangdong-province-china
#4
Yuanan Hu, Wenfeng Zhang, Hefa Cheng, Shu Tao
Arsenic-based feed additives, such as roxarsone (ROX), are still legally and widely used in food animal production in many countries. This study was conducted to systematically characterize the content and speciation of arsenic in chicken tissues from live poultry markets and in commercial chicken feeds in Guangdong, a major poultry production and consumption province in China, and to assess the corresponding public health risk. The total arsenic contents in the commercial feeds could be modeled as a mixture of two log-normal distributions (geometric means: 0...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28212591/maternal-bonding-through-pregnancy-and-postnatal-findings-from-an-australian-longitudinal-study
#5
Larissa Rossen, Delyse Hutchinson, Judy Wilson, Lucinda Burns, Steve Allsop, Elizabeth J Elliott, Sue Jacobs, Jacqui A Macdonald, Craig Olsson, Richard P Mattick
Background Mother-infant bonding provides the foundation for secure attachment through the lifespan and organizes many facets of infant social-emotional development, including later parenting. Aims To describe maternal bonding to offspring across the pregnancy and postnatal periods, and to examine a broad range of sociodemographic and psychosocial predictors of the maternal-offspring bond. Methods Data were drawn from a sample of 372 pregnant women participating in an Australian population-based longitudinal study of postnatal health and development...
February 17, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28210929/effect-of-boswellia-serrata-resin-supplementation-on-basic-chemical-and-mineral-element-composition-in-the-muscles-and-liver-of-broiler-chickens
#6
A R M Al-Yasiry, B Kiczorowska, W Samolińska
Supplementation of broiler chicken diets with resin rich in bioactive components, such as different boswellic acids, could improve productivity, chemical composition, and nutritive value of produced meat. The aim of the study was to assess the effect of different levels of Boswellia serrata (BSR) supplementation in broiler chicken diet on the basic chemical composition and the Ca, P, Mg, Fe, Zn, and Cu contents in the breast and drumstick muscles and liver. The analyses involved 200 Ross 308 chickens. The broiler chickens were fed with diets containing 0 (BSR0), 1...
February 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28208965/long-term-outcomes-of-kangaroo-mother-care-in-very-low-birth-weight-infants
#7
Sunil Gavhane, Deepak Eklare, Haseeb Mohammad
INTRODUCTION: Kangaroo Mother Care (KMC) has been gaining acceptance as an effective alternative to incubator based Conventional Medical Care (CMC) in preterm or Low Birth Weight (LBW) infants especially in resource scarce developing countries. AIM: To report and analyse the long-term effects of KMC for relatively stable Very Low Birth Weight (VLBW) infants on nutritional indicators and feeding conditions at 6-12 months of corrected age. MATERIALS AND METHODS: This randomized controlled trial was done at a Level III Neonatal Intensive Care Unit (NICU) of a teaching institution in southern India...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205255/effect-of-postnatal-hiv-treatment-on-clinical-mastitis-and-breast-inflammation-in-hiv-infected-breast-feeding-women
#8
Sabrina Zadrozny, Daniel Westreich, Michael G Hudgens, Charles Chasela, Denise J Jamieson, Francis Martinson, Chifundo Zimba, Gerald Tegha, Irving Hoffman, William C Miller, Brian W Pence, Caroline C King, Athena P Kourtis, Wezi Msungama, Charles van der Horst
BACKGROUND: The relationship between mastitis and antiretroviral therapy among HIV-positive, breast-feeding women is unclear. METHODS: In the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study, conducted in Lilongwe, Malawi, 2369 mother-infant pairs were randomized to a nutritional supplement group and to one of three treatment groups: maternal antiretroviral therapy (ART), infant nevirapine (NVP) or standard of care for 24 weeks of exclusive breast-feeding and 4 weeks of weaning...
March 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28203331/mothers-attitudes-toward-feeding-twin-babies-in-the-first-six-months-of-life-a-sample-from-sakarya-turkey
#9
Nursan Cinar, Dilek Kose, Muge Alvur, Ozlem Dogu
BACKGROUND: It is stated in the literature that a mother's breast milk is sufficient for more than one baby. OBJECTIVES: This descriptive study aimed to determine whether twin babies are breastfed during their first six months of life. MATERIALS AND METHODS: We studied the twin birth cases in a state hospital in Sakarya, Turkey between October 2011 and March 2013. The population of the study consisted of entire mothers who had delivered twins in the maternity ward of the hospital...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28202638/vitamin-concentrations-in-human-milk-vary-with-time-within-feed-circadian-rhythm-and-single-dose-supplementation
#10
Daniela Hampel, Setareh Shahab-Ferdows, M Munirul Islam, Janet M Peerson, Lindsay H Allen
Background: Human milk is the subject of many studies, but procedures for representative sample collection have not been established. Our improved methods for milk micronutrient analysis now enable systematic study of factors that affect its concentrations.Objective: We evaluated the effects of sample collection protocols, variations in circadian rhythms, subject variability, and acute maternal micronutrient supplementation on milk vitamin concentrations.Methods: In the BMQ (Breast-Milk-Quality) study, we recruited 18 healthy women (aged 18-26 y) in Dhaka, Bangladesh, at 2-4 mo of lactation for a 3-d supplementation study...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28202520/evolution-of-cancer-stem-like-cells-in-endocrine-resistant-metastatic-breast-cancers-is-mediated-by-stromal-microvesicles
#11
Pasquale Sansone, Marjan Berishaj, Vinagolu K Rajasekhar, Claudio Ceccarelli, Qing Chang, Antonio Strillacci, Claudia Savini, Lauren Shapiro, Robert Bowman, Chiara Mastroleo, Sabrina De Carolis, Laura Daly, Alberto Benito-Martin, Fabiana Perna, Nicola Fabbri, John H Healey, Enzo Spisni, Monica Cricca, David Lyden, Massimiliano Bonafé, Jacqueline Bromberg
The hypothesis that microvesicle (MV)-mediated microRNA transfer converts non-cancer stem cells into cancer stem cells (CSCs) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstrating how MV derived from cancer associated fibroblasts (CAF) transfer miR-221 to promote hormonal therapy resistance (HTR) in models of luminal breast cancer. We determined that CAF-derived MV horizontally transferred miR221 to tumor cells and, in combination with hormone therapy activated an ERlo/Notchhi feed-forward loop responsible for the generation of CD133hi CSC...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28197048/hypernatremia-in-the-neonate-neonatal-hypernatremia-and-hypernatremic-dehydration-in-neonates-receiving-exclusive-breastfeeding
#12
Nilofer Salim Mujawar, Archana Nirmal Jaiswal
AIMS AND OBJECTIVES: Evaluation of neonatal hypernatremia and hypernatremic dehydration in neonates receiving exclusive breastfeeding. INTRODUCTION: Neonatal hypernatremia is a serious condition in the newborn period. We present infants with hypernatremic dehydration due to breast milk (BM) hypernatremia. Hypernatremic dehydration in breast-fed newborns is usually secondary to insufficient lactation. We present the neonatal hypernatremia and hypernatremic dehydration encountered between January and December, 2012, its causes and treatment...
January 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28190990/the-translation-of-lipid-profiles-to-nutritional-biomarkers-in-the-study-of-infant-metabolism
#13
Animesh Acharjee, Philippa Prentice, Carlo Acerini, James Smith, Ieuan A Hughes, Ken Ong, Julian L Griffin, David Dunger, Albert Koulman
INTRODUCTION: Links between early life exposures and later health outcomes may, in part, be due to nutritional programming in infancy. This hypothesis is supported by observed long-term benefits associated with breastfeeding, such as better cognitive development in childhood, and lower risks of obesity and high blood pressure in later life. However, the possible underlying mechanisms are expected to be complex and may be difficult to disentangle due to the lack of understanding of the metabolic processes that differentiate breastfed infants compared to those receiving just formula feed...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28190895/clinical-question-in-post-partum-first-time-mothers-what-interventions-are-successful-for-helping-women-sustain-exclusive-breast-feeding-for-one-month-or-more
#14
Mai-Thao Nguyen, Gabriella Snow, Heather Wheeler, Tomas Owens
No abstract text is available yet for this article.
November 2016: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/28179416/cohort-profile-for-the-nurture-observational-study-examining-associations-of-multiple-caregivers-on-infant-growth-in-the-southeastern-usa
#15
Sara E Benjamin Neelon, Truls Østbye, Gary G Bennett, Richard M Kravitz, Shayna M Clancy, Marissa Stroo, Edwin Iversen, Cathrine Hoyo
PURPOSE: Childcare has been associated with obesity in children in cross-sectional and longitudinal studies, although some observed no association. Few studies have focused on care during infancy, a period when children may be especially vulnerable. PARTICIPANTS: The Nurture Study is an observational birth cohort designed to assess longitudinal associations of childcare and the presence of multiple caregivers on infant adiposity and weight trajectories throughout the first year of life...
February 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28179267/obesity-and-pregnancy-mechanisms-of-short-term-and-long-term-adverse-consequences-for-mother-and-child
#16
REVIEW
Patrick M Catalano, Kartik Shankar
Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased...
February 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28179115/chemical-composition-of-the-essential-oils-and-extracts-of-achillea-species-and-their-biological-activities-a-review
#17
REVIEW
Majid Mohammadhosseini, Satyajit D Sarker, Abolfazl Akbarzadeh
ETHNOPHARMACOLOGICAL RELEVANCE: The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of view, they heve been recommended as effective tonic, sedative, diuretic and carminative remedies and extensively prescribed for the treatment of stomachache, inflammation, gastrointestinal, hemorrhoid, hay fever, and wound healing in indigenous medicines...
February 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28174265/sgk3-sustains-er%C3%AE-signaling-and-drives-acquired-aromatase-inhibitor-resistance-through-maintaining-endoplasmic-reticulum-homeostasis
#18
Yuanzhong Wang, Dujin Zhou, Sheryl Phung, Charles Warden, Rumana Rashid, Nymph Chan, Shiuan Chen
Many estrogen receptor alpha (ERα)-positive breast cancers initially respond to aromatase inhibitors (AIs), but eventually acquire resistance. Here, we report that serum- and glucocorticoid-inducible kinase 3 (SGK3), a kinase transcriptionally regulated by ERα in breast cancer, sustains ERα signaling and drives acquired AI resistance. SGK3 is up-regulated and essential for endoplasmic reticulum (EnR) homeostasis through preserving sarcoplasmic/EnR calcium ATPase 2b (SERCA2b) function in AI-resistant cells...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28174119/potential-transfer-of-neurotoxic-amino-acid-%C3%AE-n-methylamino-alanine-bmaa-from-mother-to-infant-during-breast-feeding-predictions-from-human-cell-lines
#19
Marie Andersson, Lisa Ersson, Ingvar Brandt, Ulrika Bergström
β-N-methylamino-alanine (BMAA) is a non-protein amino acid produced by cyanobacteria, diatoms and dinoflagellates. BMAA has potential to biomagnify in a terrestrial food chain, and to bioaccumulate in fish and shellfish. We have reported that administration of [(14)C]l-BMAA to lactating mice and rats results in a mother to off-spring transfer via the milk. A preferential enantiomer-specific uptake of [(14)C]l-BMAA has also been demonstrated in differentiated murine mammary epithelium HC11 cells. These findings, together with neurotoxic effects of BMAA demonstrated both in vitro and in vivo, highlight the need to determine whether such transfer could also occur in humans...
February 4, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28173897/exclusive-breast-feeding-promotion-among-hiv-infected-women-in-south-africa-an-information-motivation-behavioural-skills-model-based-pilot-intervention
#20
Emily L Tuthill, Lisa M Butler, Jennifer A Pellowski, Jacqueline M McGrath, Regina M Cusson, Robert K Gable, Jeffrey D Fisher
OBJECTIVE: Exclusive breast-feeding (EBF) provides optimal nutrition for infants and mothers. The practice of EBF while adhering to antiretroviral medication decreases the risk of mother-to-child transmission of HIV from approximately 25 % to less than 5 %. Thus the WHO recommends EBF for the first 6 months among HIV-infected women living in resource-limited settings; however, EBF rates remain low. In the present study our aim was to design and implement a pilot intervention promoting EBF among HIV-infected women...
February 8, 2017: Public Health Nutrition
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