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https://www.readbyqxmd.com/read/28540766/hiv-1-full-genome-phylogenetics-of-generalized-epidemics-in-sub-saharan-africa-impact-of-missing-nucleotide-characters-in-next-generation-sequences
#1
Oliver Ratmann, Chris Wymant, Caroline Colijn, Siva Danaviah, M Essex, Simon D W Frost, Astrid Gall, Simani Gaiseitsiwe, Mary Grabowski, Ronald Gray, Stephane Guindon, Arndt von Haeseler, Pontiano Kaleebu, Michelle Kendall, Alexey Kozlov, Justen Manasa, Bui Quang Minh, Sikhulile Moyo, Vladimir Novitsky, Rebecca Nsubuga, Sureshnee Pillay, Thomas C Quinn, David Serwadda, Deogratius Ssemwanga, Alexandros Stamatakis, Jana Trifinopoulos, Maria Wawer, Andrew Leigh Brown, Tulio de Oliveira, Paul Kellam, Deenan Pillay, Christophe Fraser
To characterize HIV-1 transmission dynamics in regions where the burden of HIV-1 is greatest, the 'Phylogenetics and Networks for Generalised HIV Epidemics in Africa' consortium (PANGEA-HIV) is sequencing full-genome viral isolates from across sub-Saharan Africa. We report the first 3,985 PANGEA-HIV consensus sequences from four cohort sites (Rakai Community Cohort Study, n=2,833; MRC/UVRI Uganda, n=701; Mochudi Prevention Project, n=359; Africa Health Research Institute Resistance Cohort, n=92). Next-generation sequencing success rates varied: more than 80% of the viral genome from the gag to the nef genes could be determined for all sequences from South Africa, 75% of sequences from Mochudi, 60% of sequences from MRC/UVRI Uganda, and 22% of sequences from Rakai...
May 25, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28539487/characterization-of-the-mammalian-rna-exonuclease-5-nef-sp-as-a-testis-specific-nuclear-3-%C3%A2-5-exoribonuclease
#2
Sara Silva, David Homolka, Ramesh S Pillai
Ribonucleases catalyse maturation of functional RNAs or mediate degradation of cellular transcripts, activities that are critical for gene expression control. Here we identify a previously uncharacterized mammalian nuclease family member NEF-sp [RNA exonuclease 5 (REXO5) or LOC81691] as a testis-specific factor. Recombinant human NEF-sp demonstrates a divalent metal ion-dependent 3'→5' exoribonuclease activity. This activity is specific to single-stranded RNA substrates and is independent of their length...
May 24, 2017: RNA
https://www.readbyqxmd.com/read/28539411/substrate-binding-by-the-yeast-hsp110-nucleotide-exchange-factor-and-molecular-chaperone-sse1-is-not-obligate-for-its-biological-activities
#3
Veronica M Garcia, Nadinath B Nillegoda, Bernd Bukau, Kevin A Morano
The highly conserved heat-shock protein 70 (Hsp70) is a ubiquitous molecular chaperone essential for maintaining cellular protein homeostasis. The related protein Hsp110 (Sse1/Sse2 in Saccharomyces cerevisiae) functions as a nucleotide exchange factor (NEF) to regulate the protein folding activity of Hsp70. Hsp110/Sse1 can additionally prevent protein aggregation in vitro via its substrate binding domain (SBD), but the cellular roles of this "holdase" activity remain poorly defined. We generated and characterized an Sse1 mutant that separates, for the first time, its nucleotide exchange and substrate binding functions...
May 24, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28530212/-measurements-of-vancomycin-concentrations-in-the-blood-a-method-of-personalization-the-antibiotic-therapy-in-patients-with-chronic-kidney-disease
#4
Joanna Pondel, Piotr Krajewski, Natalia Królikowska, Aleksandra Tobiasz, Hanna Augustyniak-Bartosik, Magdalena Hurkacz
Therapeutic Drug Monitoring is a recognized method of personalizing treatment, having particular application in patients with chronic kidney disease who have frequent infections, requiring administration of vancomycin. International guidelines indicate the need to adjust the dose of the drug to the state of renal function. The recommended therapeutic ranges of minimum and maximum levels should be achieved in order to increase the effectiveness and safety of treatment. AIM: The aim of this study was to evaluate the usefulness of measuring the concentration of vancomycin in patients with chronic kidney disease due to bacterial infection...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28515666/performance-of-algorithms-that-reconstruct-missing-transverse-momentum-in-formula-see-text-8-tev-proton-proton-collisions-in-the-atlas-detector
#5
G Aad, B Abbott, J Abdallah, O Abdinov, B Abeloos, R Aben, M Abolins, O S AbouZeid, H Abramowicz, H Abreu, R Abreu, Y Abulaiti, B S Acharya, L Adamczyk, D L Adams, J Adelman, S Adomeit, T Adye, A A Affolder, T Agatonovic-Jovin, J Agricola, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, H Akerstedt, T P A Åkesson, A V Akimov, G L Alberghi, J Albert, S Albrand, M J Alconada Verzini, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, G Alimonti, L Alio, J Alison, S P Alkire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, K Amako, Y Amaral Coutinho, C Amelung, D Amidei, S P Amor Dos Santos, A Amorim, S Amoroso, N Amram, G Amundsen, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, G Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, P Anger, A Angerami, F Anghinolfi, A V Anisenkov, N Anjos, A Annovi, M Antonelli, A Antonov, J Antos, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, A T H Arce, F A Arduh, J-F Arguin, S Argyropoulos, M Arik, A J Armbruster, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, B Åsman, L Asquith, K Assamagan, R Astalos, M Atkinson, N B Atlay, K Augsten, G Avolio, B Axen, M K Ayoub, G Azuelos, M A Baak, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, M Backhaus, P Bagiacchi, P Bagnaia, Y Bai, J T Baines, O K Baker, E M Baldin, P Balek, T Balestri, F Balli, W K Balunas, E Banas, Sw Banerjee, A A E Bannoura, L Barak, E L Barberio, D Barberis, M Barbero, T Barillari, T Barklow, N Barlow, S L Barnes, B M Barnett, R M Barnett, Z Barnovska, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, A Basye, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, R Beccherle, P Bechtle, H P Beck, K Becker, M Becker, M Beckingham, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, L J Beemster, T A Beermann, M Begel, J K Behr, C Belanger-Champagne, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, O Beltramello, O Benary, D Benchekroun, M Bender, K Bendtz, N Benekos, Y Benhammou, E Benhar Noccioli, J A Benitez Garcia, D P Benjamin, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, F Berghaus, J Beringer, C Bernard, N R Bernard, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, F Bertolucci, C Bertsche, D Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, C Betancourt, S Bethke, A J Bevan, W Bhimji, R M Bianchi, L Bianchini, M Bianco, O Biebel, D Biedermann, N V Biesuz, M Biglietti, J Bilbao De Mendizabal, H Bilokon, M Bindi, S Binet, A Bingul, C Bini, S Biondi, D M Bjergaard, C W Black, J E Black, K M Black, D Blackburn, R E Blair, J-B Blanchard, J E Blanco, T Blazek, I Bloch, C Blocker, W Blum, U Blumenschein, S Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, M Boehler, D Boerner, J A Bogaerts, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, T Bold, V Boldea, A S Boldyrev, M Bomben, M Bona, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, V Bortolotto, K Bos, D Boscherini, M Bosman, J Boudreau, J Bouffard, E V Bouhova-Thacker, D Boumediene, C Bourdarios, N Bousson, S K Boutle, A Boveia, J Boyd, I R Boyko, J Bracinik, A Brandt, G Brandt, O Brandt, U Bratzler, B Brau, J E Brau, H M Braun, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, T M Bristow, D Britton, D Britzger, F M Brochu, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, J Brosamer, E Brost, P A Bruckman de Renstrom, D Bruncko, R Bruneliere, A Bruni, G Bruni, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, L Bugge, M K Bugge, O Bulekov, D Bullock, H Burckhart, S Burdin, C D Burgard, B Burghgrave, S Burke, I Burmeister, E Busato, D Büscher, V Büscher, P Bussey, J M Butler, A I Butt, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, S Cabrera Urbán, D Caforio, V M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, L P Caloba, D Calvet, S Calvet, T P Calvet, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Campoverde, V Canale, A Canepa, M Cano Bret, J Cantero, R Cantrill, T Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R Caputo, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, L Carminati, S Caron, E Carquin, G D Carrillo-Montoya, J R Carter, J Carvalho, D Casadei, M P Casado, M Casolino, D W Casper, E Castaneda-Miranda, A Castelli, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, D Cavalli, M Cavalli-Sforza, V Cavasinni, F Ceradini, L Cerda Alberich, B C Cerio, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, M Cerv, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, Y L Chan, P Chang, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, S Cheatham, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, H Chen, K Chen, S Chen, S Chen, X Chen, Y Chen, H C Cheng, Y Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, V Chernyatin, E Cheu, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, R T Chislett, A Chitan, M V Chizhov, K Choi, S Chouridou, B K B Chow, V Christodoulou, D Chromek-Burckhart, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, G Ciapetti, A K Ciftci, D Cinca, V Cindro, I A Cioara, A Ciocio, F Cirotto, Z H Citron, M Ciubancan, A Clark, B L Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Coffey, L Colasurdo, B Cole, S Cole, A P Colijn, J Collot, T Colombo, G Compostella, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, V Consorti, S Constantinescu, C Conta, G Conti, F Conventi, M Cooke, B D Cooper, A M Cooper-Sarkar, T Cornelissen, M Corradi, F Corriveau, A Corso-Radu, A Cortes-Gonzalez, G Cortiana, G Costa, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, K Cranmer, S J Crawley, G Cree, S Crépé-Renaudin, F Crescioli, W A Cribbs, M Crispin Ortuzar, M Cristinziani, V Croft, G Crosetti, T Cuhadar Donszelmann, J Cummings, M Curatolo, J Cúth, C Cuthbert, H Czirr, P Czodrowski, S D'Auria, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, A Dafinca, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, N P Dang, A C Daniells, M Danninger, M Dano Hoffmann, V Dao, G Darbo, S Darmora, J Dassoulas, A Dattagupta, W Davey, C David, T Davidek, E Davies, M Davies, P Davison, Y Davygora, E Dawe, I Dawson, R K Daya-Ishmukhametova, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, D De Pedis, A De Salvo, U De Sanctis, A De Santo, J B De Vivie De Regie, W J Dearnaley, R Debbe, C Debenedetti, D V Dedovich, I Deigaard, J Del Peso, T Del Prete, D Delgove, F Deliot, C M Delitzsch, M Deliyergiyev, A Dell'Acqua, L Dell'Asta, M Dell'Orso, M Della Pietra, D Della Volpe, M Delmastro, P A Delsart, C Deluca, D A DeMarco, S Demers, M Demichev, A Demilly, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, P O Deviveiros, A Dewhurst, S Dhaliwal, A Di Ciaccio, L Di Ciaccio, C Di Donato, A Di Girolamo, B Di Girolamo, B Di Micco, R Di Nardo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, M A Diaz, E B Diehl, J Dietrich, S Diglio, A Dimitrievska, J Dingfelder, P Dita, S Dita, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, D Dobos, M Dobre, C Doglioni, T Dohmae, J Dolejsi, Z Dolezal, B A Dolgoshein, M Donadelli, S Donati, P Dondero, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, M Dris, Y Du, J Duarte-Campderros, E Dubreuil, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, L Duflot, L Duguid, M Dührssen, M Dunford, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, M Dyndal, C Eckardt, K M Ecker, R C Edgar, W Edson, N C Edwards, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, V Ellajosyula, M Ellert, S Elles, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, O C Endner, M Endo, J S Ennis, J Erdmann, A Ereditato, G Ernis, J Ernst, M Ernst, S Errede, E Ertel, M Escalier, H Esch, C Escobar, B Esposito, A I Etienvre, E Etzion, H Evans, A Ezhilov, L Fabbri, G Facini, R M Fakhrutdinov, S Falciano, R J Falla, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, C Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, L Fayard, O L Fedin, W Fedorko, S Feigl, L Feligioni, C Feng, E J Feng, H Feng, A B Fenyuk, L Feremenga, P Fernandez Martinez, S Fernandez Perez, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, A Ferretto Parodi, F Fiedler, A Filipčič, M Filipuzzi, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, A Firan, A Fischer, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, G T Fletcher, G Fletcher, R R M Fletcher, T Flick, A Floderus, L R Flores Castillo, M J Flowerdew, G T Forcolin, A Formica, A Forti, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, F Friedrich, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, T Fusayasu, J Fuster, C Gabaldon, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, G Gagliardi, P Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, K K Gan, J Gao, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, C Gatti, A Gaudiello, G Gaudio, B Gaur, L Gauthier, I L Gavrilenko, C Gay, G Gaycken, E N Gazis, Z Gecse, C N P Gee, Ch Geich-Gimbel, M P Geisler, C Gemme, M H Genest, C Geng, S Gentile, S George, D Gerbaudo, A Gershon, S Ghasemi, H Ghazlane, B Giacobbe, S Giagu, P Giannetti, B Gibbard, S M Gibson, M Gignac, M Gilchriese, T P S Gillam, D Gillberg, G Gilles, D M Gingrich, N Giokaris, M P Giordani, F M Giorgi, F M Giorgi, P F Giraud, P Giromini, D Giugni, C Giuliani, M Giulini, B K Gjelsten, S Gkaitatzis, I Gkialas, E L Gkougkousis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J R Goddard, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, J Goncalves Pinto Firmino Da Costa, L Gonella, S González de la Hoz, G Gonzalez Parra, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, I Gorelov, B Gorini, E Gorini, A Gorišek, E Gornicki, A T Goshaw, C Gössling, M I Gostkin, C R Goudet, D Goujdami, A G Goussiou, N Govender, E Gozani, L Graber, I Grabowska-Bold, P O J Gradin, P Grafström, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, H M Gray, E Graziani, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, J P Grohs, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, L Guan, J Guenther, F Guescini, D Guest, O Gueta, E Guido, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, Y Guo, S Gupta, G Gustavino, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, C Guyot, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, P Haefner, S Hageböck, Z Hajduk, H Hakobyan, M Haleem, J Haley, D Hall, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A Hamilton, G N Hamity, P G Hamnett, L Han, K Hanagaki, K Hanawa, M Hance, B Haney, P Hanke, R Hanna, J B Hansen, J D Hansen, M C Hansen, P H Hansen, K Hara, A S Hard, T Harenberg, F Hariri, S Harkusha, R D Harrington, P F Harrison, F Hartjes, M Hasegawa, Y Hasegawa, A Hasib, S Hassani, S Haug, R Hauser, L Hauswald, M Havranek, C M Hawkes, R J Hawkings, A D Hawkins, T Hayashi, D Hayden, C P Hays, J M Hays, H S Hayward, S J Haywood, S J Head, T Heck, V Hedberg, L Heelan, S Heim, T Heim, B Heinemann, L Heinrich, J Hejbal, L Helary, S Hellman, C Helsens, J Henderson, R C W Henderson, Y Heng, S Henkelmann, A M Henriques Correia, S Henrot-Versille, G H Herbert, Y Hernández Jiménez, G Herten, R Hertenberger, L Hervas, G G Hesketh, N P Hessey, J W Hetherly, R Hickling, E Higón-Rodriguez, E Hill, J C Hill, K H Hiller, S J Hillier, I Hinchliffe, E Hines, R R Hinman, M Hirose, D Hirschbuehl, J Hobbs, N Hod, M C Hodgkinson, P Hodgson, A Hoecker, M R Hoeferkamp, F Hoenig, M Hohlfeld, D Hohn, T R Holmes, M Homann, T M Hong, B H Hooberman, W H Hopkins, Y Horii, A J Horton, J-Y Hostachy, S Hou, A Hoummada, J Howard, J Howarth, M Hrabovsky, I Hristova, J Hrivnac, T Hryn'ova, A Hrynevich, C Hsu, P J Hsu, S-C Hsu, D Hu, Q Hu, Y Huang, Z Hubacek, F Hubaut, F Huegging, T B Huffman, E W Hughes, G Hughes, M Huhtinen, T A Hülsing, N Huseynov, J Huston, J Huth, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, E Ideal, Z Idrissi, P Iengo, O Igonkina, T Iizawa, Y Ikegami, M Ikeno, Y Ilchenko, D Iliadis, N Ilic, T Ince, G Introzzi, P Ioannou, M Iodice, K Iordanidou, V Ippolito, A Irles Quiles, C Isaksson, M Ishino, M Ishitsuka, R Ishmukhametov, C Issever, S Istin, J M Iturbe Ponce, R Iuppa, J Ivarsson, W Iwanski, H Iwasaki, J M Izen, V Izzo, S Jabbar, B Jackson, M Jackson, P Jackson, V Jain, K B Jakobi, K Jakobs, S Jakobsen, T Jakoubek, D O Jamin, D K Jana, E Jansen, R Jansky, J Janssen, M Janus, G Jarlskog, N Javadov, T Javůrek, F Jeanneau, L Jeanty, J Jejelava, G-Y Jeng, D Jennens, P Jenni, J Jentzsch, C Jeske, S Jézéquel, H Ji, J Jia, H Jiang, Y Jiang, S Jiggins, J Jimenez Pena, S Jin, A Jinaru, O Jinnouchi, P Johansson, K A Johns, W J Johnson, K Jon-And, G Jones, R W L Jones, S Jones, T J Jones, J Jongmanns, P M Jorge, J Jovicevic, X Ju, A Juste Rozas, M K Köhler, M Kaci, A Kaczmarska, M Kado, H Kagan, M Kagan, S J Kahn, E Kajomovitz, C W Kalderon, A Kaluza, S Kama, A Kamenshchikov, N Kanaya, S Kaneti, V A Kantserov, J Kanzaki, B Kaplan, L S Kaplan, A Kapliy, D Kar, K Karakostas, A Karamaoun, N Karastathis, M J Kareem, E Karentzos, M Karnevskiy, S N Karpov, Z M Karpova, K Karthik, V Kartvelishvili, A N Karyukhin, K Kasahara, L Kashif, R D Kass, A Kastanas, Y Kataoka, C Kato, A Katre, J Katzy, K Kawagoe, T Kawamoto, G Kawamura, S Kazama, V F Kazanin, R Keeler, R Kehoe, J S Keller, J J Kempster, K Kentaro, H Keoshkerian, O Kepka, B P Kerševan, S Kersten, R A Keyes, F Khalil-Zada, H Khandanyan, A Khanov, A G Kharlamov, T J Khoo, V Khovanskiy, E Khramov, J Khubua, S Kido, H Y Kim, S H Kim, Y K Kim, N Kimura, O M Kind, B T King, M King, S B King, J Kirk, A E Kiryunin, T Kishimoto, D Kisielewska, F Kiss, K Kiuchi, O Kivernyk, E Kladiva, M H Klein, M Klein, U Klein, K Kleinknecht, P Klimek, A Klimentov, R Klingenberg, J A Klinger, T Klioutchnikova, E-E Kluge, P Kluit, S Kluth, J Knapik, E Kneringer, E B F G Knoops, A Knue, A Kobayashi, D Kobayashi, T Kobayashi, M Kobel, M Kocian, P Kodys, T Koffas, E Koffeman, L A Kogan, S Kohlmann, T Koi, H Kolanoski, M Kolb, I Koletsou, A A Komar, Y Komori, T Kondo, N Kondrashova, K Köneke, A C König, T Kono, R Konoplich, N Konstantinidis, R Kopeliansky, S Koperny, L Köpke, A K Kopp, K Korcyl, K Kordas, A Korn, A A Korol, I Korolkov, E V Korolkova, O Kortner, S Kortner, T Kosek, V V Kostyukhin, V M Kotov, A Kotwal, A Kourkoumeli-Charalampidi, C Kourkoumelis, V Kouskoura, A Koutsman, R Kowalewski, T Z Kowalski, W Kozanecki, A S Kozhin, V A Kramarenko, G Kramberger, D Krasnopevtsev, M W Krasny, A Krasznahorkay, J K Kraus, A Kravchenko, M Kretz, J Kretzschmar, K Kreutzfeldt, P Krieger, K Krizka, K Kroeninger, H Kroha, J Kroll, J Kroseberg, J Krstic, U Kruchonak, H Krüger, N Krumnack, A Kruse, M C Kruse, M Kruskal, T Kubota, H 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Willis, S Willocq, J A Wilson, I Wingerter-Seez, F Winklmeier, B T Winter, M Wittgen, J Wittkowski, S J Wollstadt, M W Wolter, H Wolters, B K Wosiek, J Wotschack, M J Woudstra, K W Wozniak, M Wu, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, D Xu, L Xu, B Yabsley, S Yacoob, R Yakabe, D Yamaguchi, Y Yamaguchi, A Yamamoto, S Yamamoto, T Yamanaka, K Yamauchi, Y Yamazaki, Z Yan, H Yang, H Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, A L Yen, E Yildirim, K Yorita, R Yoshida, K Yoshihara, C Young, C J S Young, S Youssef, D R Yu, J Yu, J M Yu, J Yu, L Yuan, S P Y Yuen, I Yusuff, B Zabinski, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, A Zaman, S Zambito, L Zanello, D Zanzi, C Zeitnitz, M Zeman, A Zemla, J C Zeng, Q Zeng, K Zengel, O Zenin, T Ženiš, D Zerwas, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, R Zhang, R Zhang, X Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zhong, B Zhou, C Zhou, L Zhou, L Zhou, M Zhou, N Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, A Zibell, D Zieminska, N I Zimine, C Zimmermann, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, M Zur Nedden, G Zurzolo, L Zwalinski
The reconstruction and calibration algorithms used to calculate missing transverse momentum ([Formula: see text] ) with the ATLAS detector exploit energy deposits in the calorimeter and tracks reconstructed in the inner detector as well as the muon spectrometer. Various strategies are used to suppress effects arising from additional proton-proton interactions, called pileup, concurrent with the hard-scatter processes. Tracking information is used to distinguish contributions from the pileup interactions using their vertex separation along the beam axis...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28505454/perturbation-response-scanning-reveals-key-residues-for-allosteric-control-in-hsp70
#6
David Penkler, Ozge Sensoy, Canan Atilgan, Ozlem Tastan Bishop
Hsp70 molecular chaperones play an important role in maintaining cellular homeostasis, and are implicated in a wide array of cellular processes including protein recovery from aggregates, cross membrane protein translocation, and protein biogenesis. Hsp70 consists of two domains, a nucleotide binding domain (NBD) and a substrate binding domain (SBD), each of which communicates via an allosteric mechanism such that the protein interconverts between two functional states, an ATP bound open conformation and an ADP bound closed conformation...
May 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28503929/rare-control-of-sivmac239-infection-in-a-vaccinated-rhesus-macaque
#7
Mauricio de Aguiar Martins, Damien C Tully, Young C Shin, Lucas Gonzalez-Nieto, Kim Weisgrau, David J Bean, Rujuta Gadgil, Martin J Gutman, Aline Domingues, Helen Skye Maxwell, Diogo Magnani, Michael Ricciardi, Nuria Pedreño-Lopez, Varian Bailey, Michael Cruz, Noemia S Lima, Myrna Bonaldo, John Altman, Eva Rakasz, Saverio Capuano, Keith Reimann, Michael Piatak, Jeffrey Lifson, Ronald Desrosiers, Todd Allen, David Watkins
Effector memory T-cell (T<sub>EM</sub>) responses display potent antiviral properties and have been linked to stringent control of simian immunodeficiency virus (SIV) replication. Since recurrent antigen stimulation drives the differentiation of CD8<sup>+</sup> T-cells toward the T<sub>EM</sub> phenotype, here we incorporated a persistent herpesviral vector into a heterologous prime/boost/boost vaccine approach in order to maximize the induction of T<sub>EM</sub> responses...
May 13, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28500742/amino-acids-at-positions-3-168-and-169-are-associated-with-the-ability-of-nef-proteins-from-hiv-1-crf01_ae-to-downmodulate-cd4
#8
Wen-Dong Kuang, Yan-Heng Zhou, Ping Zhong, Chiyu Zhang, Jian-Hua Wang
Several HIV-1 subtypes are co-circulating among various high-risk groups in China, and an increasing prevalence of CRF01_AE was observed among MSM (men who have sex with men) within recent years. Patients infected with CRF01_AE may experience a more rapid disease progression than patients infected with non-CRF01_AE; however, the underlying mechanisms remains elusive. HIV-1 Nef is a multifunctional protein and plays critical roles in viral pathogenesis. Nef downregulates CD4 and human leukocyte antigen (HLA) to promote viral transmission and escape from the host immune response...
May 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28479111/co-utilization-of-a-tlr5-agonist-and-nano-formulation-of-hiv-1-vaccine-candidate-leads-to-increased-vaccine-immunogenicity-and-decreased-immunogenic-dose-a-preliminary-study
#9
Hajar Rostami, Masoumeh Ebtekar, Mehdi Shafiee Ardestani, Mohammad Hossein Yazdi, Mehdi Mahdavi
Vaccines currently available for AIDS show poor efficiency, demonstrating the need for new strategies to increase their immunogenicity. In this study, the HIV-1P24-Nef peptide was used as a model vaccine, followed by utilization of a novel strategy to increase its immunogenicity. There is a growing interest in using TLR agonists for vaccine formulations. Such molecules bind to their receptors on immune cells, especially the cell surface of antigen presenting cells, thereby activating these cells and inflammatory responses...
May 4, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28472049/evaluation-of-a-novel-serious-game-based-assessment-tool-for-patients-with-alzheimer-s-disease
#10
Vanessa Vallejo, Patric Wyss, Luca Rampa, Andrei V Mitache, René M Müri, Urs P Mosimann, Tobias Nef
Despite growing interest in developing ecological assessment of difficulties in patients with Alzheimer's disease new methods assessing the cognitive difficulties related to functional activities are missing. To complete current evaluation, the use of Serious Games can be a promising approach as it offers the possibility to recreate a virtual environment with daily living activities and a precise and complete cognitive evaluation. The aim of the present study was to evaluate the usability and the screening potential of a new ecological tool for assessment of cognitive functions in patients with Alzheimer's disease...
2017: PloS One
https://www.readbyqxmd.com/read/28462903/long-term-outcomes-after-tavi-in-patients-with-different-types-of-aortic-stenosis-the-conundrum-of-low-flow-low-gradient-and-low-ejection-fraction
#11
Miriam Puls, Kerstin Pia Korte, Annalen Bleckmann, Mark Huenlich, Bernhard C Danner, Friedrich Schoendube, Gerd Hasenfuß, Claudius Jacobshagen, Wolfgang Schillinger
AIMS: We examined the impact of guidelines-defined subtypes of severe aortic stenosis (AS) on long-term outcomes after TAVI. METHODS AND RESULTS: 400 consecutive patients who underwent TAVI (203 transapical, 197 transfemoral) at our institution 8/2008-3/2013 were followed systematically (up to 7 years). 147 individuals suffered from NEF-HG AS (LV-EF ≥50%, high Pmean ≥40mmHg), 63 from LEF-HG AS (LV-EF <50%, high gradient), 77 from PLF-LG AS (LV-EF ≥50%, low gradient, stroke volume index (SVI) <35 ml/m²), and 81 from LEF-LG AS (LV-EF <50%, low gradient)...
May 2, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28436888/neuromorphic-hardware-architecture-using-the-neural-engineering-framework-for-pattern-recognition
#12
Runchun Wang, Chetan Singh Thakur, Gregory Cohen, Tara Julia Hamilton, Jonathan Tapson, Andre van Schaik
We present a hardware architecture that uses the neural engineering framework (NEF) to implement large-scale neural networks on field programmable gate arrays (FPGAs) for performing massively parallel real-time pattern recognition. NEF is a framework that is capable of synthesising large-scale cognitive systems from subnetworks and we have previously presented an FPGA implementation of the NEF that successfully performs nonlinear mathematical computations. That work was developed based on a compact digital neural core, which consists of 64 neurons that are instantiated by a single physical neuron using a time-multiplexing approach...
June 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28431573/a-highly-pathogenic-simian-human-immunodeficiency-virus-effectively-produces-infectious-virions-compared-with-a-less-pathogenic-virus-in-cell-culture
#13
Shoya Iwanami, Yusuke Kakizoe, Satoru Morita, Tomoyuki Miura, Shinji Nakaoka, Shingo Iwami
BACKGROUND: The host range of human immunodeficiency virus (HIV) is quite narrow. Therefore, analyzing HIV-1 pathogenesis in vivo has been limited owing to lack of appropriate animal model systems. To overcome this, chimeric simian and human immunodeficiency viruses (SHIVs) that encode HIV-1 Env and are infectious to macaques have been developed and used to investigate the pathogenicity of HIV-1 in vivo. So far, we have many SHIV strains that show different pathogenesis in macaque experiments...
April 21, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28420601/what-older-people-like-to-play-genre-preferences-and-acceptance-of-casual-games
#14
Alvin Chesham, Patric Wyss, René Martin Müri, Urs Peter Mosimann, Tobias Nef
BACKGROUND: In recent computerized cognitive training studies, video games have emerged as a promising tool that can benefit cognitive function and well-being. Whereas most video game training studies have used first-person shooter (FPS) action video games, subsequent studies found that older adults dislike this type of game and generally prefer casual video games (CVGs), which are a subtype of video games that are easy to learn and use simple rules and interfaces. Like other video games, CVGs are organized into genres (eg, puzzle games) based on the rule-directed interaction with the game...
April 18, 2017: JMIR Serious Games
https://www.readbyqxmd.com/read/28413318/genetic-defects-in-the-nef-gene-are-associated-with-korean-red-ginseng-intake-monitoring-of-nef-sequence-polymorphisms-over-20%C3%A2-years
#15
Young-Keol Cho, Jung-Eun Kim, Jun-Hee Woo
BACKGROUND: The presence of gross deletions in the human immunodeficiency virus nef gene (gΔnef) is associated with long-term nonprogression of infected patients. Here, we investigated how quickly genetic defects in the nef gene are associated with Korean Red Ginseng (KRG) intake in 10 long-term slow progressors. METHODS: This study was divided into three phases over a 20-yr period; baseline, KRG intake alone, and KRG plus highly active antiretroviral therapy (ART)...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28370302/comparative-genetic-variability-in-hiv-1-subtype-c-nef-gene-in-early-age-groups-of-infants
#16
Uma Sharma, Poonam Gupta, Megha Singhal, Supriya Singh, Sunil Gupta, Srinivas Venkatesh, Arvind Rai, Mohammad Husain
Targeting properties of vertically transmitted viruses in early infancy is important to understand disease progression. To investigate genotypic characteristics of transmitted viruses, blood samples were obtained from infants aged 6 weeks-18 months, categorized in two age groups, acute (<6 months) and early (>6-18 months). Nef having an important role in pathogenesis was selected to explore the viral characteristics. A total of 57 PCR positive samples, amplified by nef gene were sequenced. Analysis showed that 50 sequences belonged to subtype C...
March 31, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28370166/mechanism-of-arsenite-toxicity-in-embryonic-stem-cells
#17
Naimisha Beeravolu, Christina McKee, G Rasul Chaudhry
Environmental arsenite exposure has been linked to cancer as well as other diseases, presenting an important and serious public health problem. Toxicity of inorganic arsenite (iAs) has been investigated using animal models and cell culture, yet its developmental effects are poorly understood. This study investigated the molecular mechanism of iAs toxicity to ascertain insight into development and differentiation processes using mouse embryonic stem cells (ESCs). The results showed that iAs exposure affected morphology and integrity of ESC colonies as well as inhibited cell growth in a concentration-dependent manner, excluding concentrations <1 μM iAs which stimulated ESC growth...
April 3, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28352501/myocardial-ischemia-caused-by-subepicardial-hematoma
#18
Philippe Grieshaber, Holger Nef, Andreas Böning, Bernd Niemann
Background Bleeding from bypass anastomosis leakage occurs early after coronary artery bypass grafting. Later, once the anastomosis is covered by intima, spontaneous bleeding is unlikely. Case Description A 63-year-old male patient developed a pseudoaneurysm-like, subepicardial late-term bleeding resulting in a hematoma that compromised coronary artery flow by increasing extracoronary pressure. This resulted in severe angina pectoris (Canadian Cardiovascular Society IV) and myocardial ischemia within the affected area...
January 2017: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/28348557/dendritic-cell-response-to-hiv-1-is-controlled-by-differentiation-programs-in-the-cells-and-strain-specific-properties-of-the-virus
#19
Aikaterini Nasi, Sylvie Amu, Mårten Göthlin, Marianne Jansson, Noemi Nagy, Francesca Chiodi, Bence Réthi
Dendritic cells (DCs) are potent antigen-presenting cells that might play contradictory roles during HIV-1 infection, contributing not only to antiviral immunity but also to viral dissemination and immune evasion. Although DCs are characterized by enormous functional diversity, it has not been analyzed how differentially programmed DCs interact with HIV-1. We have previously described the reprogramming of DC development by endogenously produced lactic acid that accumulated in a cell culture density-dependent manner and provided a long-lasting anti-inflammatory signal to the cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28331088/bst-2-expression-modulates-small-cd4-mimetic-sensitization-of-hiv-1-infected-cells-to-adcc
#20
Jonathan Richard, Jérémie Prévost, Benjamin von Bredow, Shilei Ding, Nathalie Brassard, Halima Medjahed, Mathieu Coutu, Bruno Melillo, Frédéric Bibollet-Ruche, Beatrice H Hahn, Daniel E Kaufmann, Amos B Smith, Joseph Sodroski, Daniel Sauter, Frank Kirchhoff, Katrina Gee, Stuart J Neil, David T Evans, Andrés Finzi
Antibodies recognizing conserved CD4-induced (CD4i) epitopes on HIV-1 Env and able to mediate antibody-dependent cellular cytotoxicity (ADCC) have been shown to be present in sera from most HIV-1-infected individuals. These antibodies preferentially recognize Env in its CD4-bound conformation. CD4 downregulation by Nef and Vpu dramatically reduces exposure of CD4i HIV-1 Env epitopes and therefore reduce the susceptibility of HIV-1-infected cells to ADCC mediated by HIV+ sera. Importantly, this mechanism of immune evasion can be circumvented with small-molecule CD4-mimetics (CD4mc) which are able to transition Env into the CD4-bound conformation and sensitize HIV-1-infected cells to ADCC mediated by HIV+ sera...
March 22, 2017: Journal of Virology
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