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https://www.readbyqxmd.com/read/29457855/experimental-study-on-tgf-%C3%AE-1-mediated-cd147-expression-in-oral-submucous-fibrosis
#1
Weiming Wang, Haofeng Xiong, Zhengmao Hu, Rongjuan Zhao, Yue Hu, Wenxin Chen, Ying Han, Liudi Yang, Xin Hu, Can Wang, Ting Mao, Kun Xia, Tong Su
OBJECTIVE: Although previous evidence indicates that CD147 is closely involved in the progression of organ fibrosis and various signaling pathways have been proven to regulate its expression, the role of CD147 in oral submucous fibrosis (OSF) remain largely unknown. METHODS: In the present study, we investigated the expression of CD147 and transforming growth factor β1 (TGF-β1) in human samples of an OSF tissue array by immunohistopathology. Pearson's correlation analysis was conducted to explore the correlation between CD147 and TGF-β1...
February 19, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29456770/recurrent-oral-eosinophilic-ulcers-of-the-oral-mucosa-a-case-report
#2
Norberto Sugaya, Fernanda Martignago, Decio Pinto, Dante Migliari
Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman. Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29456650/application-of-an-acellular-dermal-matrix-to-a-rabbit-model-of-oral-mucosal-defects
#3
Xiangliang Xu, Nianhui Cui, Enbo Wang
Acellular dermal matrices (ADMs) are increasingly used for the restoration of soft-tissue defects of the oral cavity due to their ability to facilitate faster healing and reduce scar formation without rejection. However, few studies have focused on the histopathology and biological mechanisms involved in their use. The aim of the present study was to observe tissue growth, histopathologic changes and altered biomolecular signatures that occur during the repair of oral defects in rabbit models over time, either with or without the employment of ADM...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29454749/microbiota-derived-indole-metabolites-promote-human-and-murine-intestinal-homeostasis-through-regulation-of-interleukin-10-receptor
#4
Erica E Alexeev, Jordi M Lanis, Daniel J Kao, Eric L Campbell, Caleb J Kelly, Kayla D Battista, Mark E Gerich, Brittany R Jenkins, Seth T Walk, Douglas J Kominsky, Sean P Colgan
Interactions between the gut microbiota and the host are important for health, where dysbiosis has emerged as a likely component of mucosal disease. The specific constituents of the microbiota that contribute to mucosal disease are not well defined. We sought to define microbial components that regulate homeostasis within the intestinal mucosa. Using an unbiased, metabolomic profiling approach, a selective depletion of indole and indole-derived metabolites was identified in murine and human colitis. Indole-3-propionic acid (IPA) was selectively diminished in circulating serum from human subjects with active colitis and that IPA served as a biomarker of disease remission...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29454616/zoledronate-modulates-intracellular-vesicle-trafficking-in-mast-cells-via-disturbing-the-interaction-of-myosinva-rab3a-and-sytaxin4-vamp7
#5
Shuang Liu, Muhammad N A Sahid, Erika Takemasa, Kazutaka Maeyama, Masaki Mogi
Nitrogen-containing bisphosphonates (NBPs) have been widely used as bone anti-resorptive drugs for the treatment of osteoclast-dependent bone disorders. Zoledronate is currently the most potent NBP, and has potential as an inhibitor of farnesyl pyrophosphate synthase. The present study was undertaken to elucidate the possible effects of zoledronate on FcεRI-dependent mast cell activity in vitro, which is essential for in maintaining homeostasis of the gastrointestinal mucosa. Treatment with zoledronate significantly diminished exocytosis of mast cells, which was reflected by a decrease of FcεRI-dependent histamine release compared to that in vehicle-treated mast cells...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29453720/cytotoxic-effect-of-chlorpyrifos-is-associated-with-activation-of-nrf-2-ho-1-system-and-inflammatory-response-in-tongue-of-male-wistar-rats
#6
Norhan M El-Sayed, Amal A M Ahmed, Manar A A Selim
Repeated administration of chlorpyrifos (CPF), an organophosphate pesticide, can increase the risk of oral cytotoxicity. The current study was designed to assess the mechanism by which CPF mediates its cytotoxic effect on lingual mucosa of rats. Twenty-four male Wistar rats were used in the present study and divided into three groups: group I: healthy rats (negative control), group II: rats treated with CPF 1/40 LD50 (3.375 mg/kg, orally/daily) for 28 days, group III: rats treated with CPF 1/10 LD50 (13.5 mg/kg, orally/daily) for 28 days...
February 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29453699/unusual-intestinal-involvement-by-paracoccidioidomycosis-diagnosed-after-oral-manifestation
#7
Rodrigo Neves-Silva, Patrícia Maria Fernandes, Alan Roger Santos-Silva, Pablo Agustin Vargas, Ricardo de Souza Cavalcante, Marcio Ajudarte Lopes
Paracoccidioidomycosis is a common deep fungus infection in South America, particularly in Brazil. It is acquired through inhalation and primary involvement of lungs. Subsequently, dissemination may occur and oral mucosa is frequently affected and actually, in most of the cases the diagnosis is established because of the oral lesions. Thus, the role of the dentist is fundamental to correct diagnosis. However, the involvement of intestine is rarely reported. The current case describes a 36-year-old man who presented abdominal pain and intestinal constipation, being suspected and then confirmed as paracoccidioidomycosis after already be diagnosed with this disease by a dentist through oral manifestations...
February 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29449053/genetic-and-epigenetic-alterations-in-the-tumour-tumour-margins-and-normal-buccal-mucosa-of-patients-with-oral-cancer
#8
N Eljabo, N Nikolic, J Carkic, D Jelovac, M Lazarevic, N Tanic, J Milasin
Despite adequate surgical resection, oral squamous cell carcinoma (OSCC) shows a high rate of recurrence and metastasis, which could be explained by the presence of molecular alterations in seemingly normal tumour margins and the entire oral mucosa. The aims of this study were (1) to assess the presence of gene amplification (c-Myc and HER2) and promoter methylation (p14 and p16) in the tumours, tumour margins, and unaffected oral mucosa of 40 OSCC patients, and (2) to evaluate the possibility of using these alterations as prognostic markers...
February 12, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29447434/alterations-in-melatonin-and-serotonin-signalling-in-the-colonic-mucosa-of-mice-with-dextran-sodium-sulfate-induced-colitis
#9
Sarah J MacEachern, Catherine M Keenan, Evangelia Papakonstantinou, Keith A Sharkey, Bhavik Anil Patel
BACKGROUND AND PURPOSE: Inflammatory bowel disease (IBD) is characterized by pain, bleeding, cramping and altered gastrointestinal (GI) function. Changes in mucosal serotonin (5-HT) signalling occur in animal models of colitis and in humans suffering from IBD. Melatonin is co-released with 5-HT from the mucosa and has a wide variety of actions in the GI tract. Here we examined how melatonin signalling is affected by colitis and determined how this relates to 5-HT signalling. EXPERIMENTAL APPROACH: Using electroanalytical approaches, we investigated how 5-HT release, reuptake and availability as well as melatonin availability are altered in dextran sodium sulfate (DSS)-induced colitis in mice...
February 15, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29446002/genomic-characterization-of-the-first-oral-avian-papillomavirus-in-a-colony-of-breeding-canaries-serinus-canaria
#10
Daniel A Truchado, Michaël A J Moens, Sergio Callejas, Javier Pérez-Tris, Laura Benítez
Papillomaviruses are non-enveloped, DNA viruses that infect skin and mucosa of a wide variety of vertebrates, causing neoplasias or simply persisting asymptomatically. Avian papillomaviruses, with six fully sequenced genomes, are the second most studied group after mammalian papillomaviruses. In this study, we describe the first oral avian papillomavirus, detected in the tongue of a dead Yorkshire canary (Serinus canaria) and in oral swabs of the same bird and other two live canaries from an aviary in Madrid, Spain...
February 14, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29445174/a-spatial-gradient-of-bacterial-diversity-in-the-human-oral-cavity-shaped-by-salivary-flow
#11
Diana M Proctor, Julia A Fukuyama, Peter M Loomer, Gary C Armitage, Stacey A Lee, Nicole M Davis, Mark I Ryder, Susan P Holmes, David A Relman
Spatial and temporal patterns in microbial communities provide insights into the forces that shape them, their functions and roles in health and disease. Here, we used spatial and ecological statistics to analyze the role that saliva plays in structuring bacterial communities of the human mouth using >9000 dental and mucosal samples. We show that regardless of tissue type (teeth, alveolar mucosa, keratinized gingiva, or buccal mucosa), surface-associated bacterial communities vary along an ecological gradient from the front to the back of the mouth, and that on exposed tooth surfaces, the gradient is pronounced on lingual compared to buccal surfaces...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29445104/genetic-modification-to-induce-cxcr2-overexpression-in-mesenchymal-stem-cells-enhances-treatment-benefits-in-radiation-induced-oral-mucositis
#12
Zongshan Shen, Jiancheng Wang, Qiting Huang, Yue Shi, Zhewei Wei, Xiaoran Zhang, Yuan Qiu, Min Zhang, Yi Wang, Wei Qin, Shuheng Huang, Yinong Huang, Xin Liu, Kai Xia, Xinchun Zhang, Zhengmei Lin
Radiation-induced oral mucositis affects patient quality of life and reduces tolerance to cancer therapy. Unfortunately, traditional treatments are insufficient for the treatment of mucositis and might elicit severe side effects. Due to their immunomodulatory and anti-inflammatory properties, the transplantation of mesenchymal stem cells (MSCs) is a potential therapeutic strategy for mucositis. However, systemically infused MSCs rarely reach inflamed sites, impacting their clinical efficacy. Previous studies have demonstrated that chemokine axes play an important role in MSC targeting...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29442455/oral-mucositis-and-saliva-iga-igg-and-igm-concentration-during-anti-tumor-treatment-in-children-suffering-from-acute-lymphoblastic-leukemia
#13
Elżbieta J Pels
BACKGROUND: Oral mucositis is a problem occurring within the oral cavity, which is the most difficult to deal with during anti-tumor treatment. The first symptom reported by the patient is discomfort. Salivary immunoglobulins play an important role in pathological processes occurring in the oral cavity. OBJECTIVES: The study objective was to assess the occurrence of oral mucositis and to assess changes in the saliva IgA, IgG, and IgM concentration in children with acute lymphoblastic leukemia during antitumor treatment...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442094/a-potential-side-effect-of-oral-topical-steroids-central-serous-chorioretinopathy
#14
Saranya George, Anita Balan
Topical corticosteroids are some of the most common drugs used in oral medicine for treating atrophic and erosive lesions that affect the mucosa. Adverse effects of these drugs include oral candidiasis with associated burning mouth and hypogeusia, hypersensitive reactions to the drug, and inhibition of the hypothalamic-pituitary-adrenal axis and secondary adrenal insufficiency. The ocular side effects of oral topical steroids are less documented. This short communication describes a case of central serous retinopathy that developed following administration of oral topical steroid...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29441943/effect-of-surface-charge-particle-size-and-modification-by-polyethylene-glycol-of-liposomes-on-their-association-with-caco-2-cells-across-an-unstirred-water-layer
#15
Y Kono, A Iwasaki, T Fujita
For the development of orally available liposomes, understanding the interaction of liposomes with the intestinal mucosa is important. An unstirred water layer (UWL) on the intestinal epithelium surface is a considerable permeability barrier for lipophilic drugs. Therefore, the effects of an UWL on liposome transport across intestinal epithelial cells must be elucidated. We evaluated the effects of the surface charge, particle size, and polyethylene glycol (PEG) modification of liposomes on their association with Caco-2 cells across an UWL...
January 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29440794/an-innovative-and-less-invasive-management-of-recurrent-pyogenic-granuloma-in-the-esthetic-zone-a-case-report-with-18-month-follow-up
#16
Superna Tiwari, Abhilash Neelakanti, Sunil Sathyanarayana
Pyogenic granuloma (PG) is a nonneoplastic, tumor-like growth commonly seen in the oral mucosa or skin. Although nonpathological, its existence might lead to complications such as secondary infections or diastema formation. Hence, surgical removal of the growth seems mandatory. Histopathologic and radiographic evaluation is essential for accurate diagnosis and to rule out malignancy. A 28-year-old systemically healthy female patient reported with a swelling which involved the interdental space of maxillary left central and lateral incisors...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29439278/delineation-of-the-extent-of-early-gastric-cancer-by-magnifying-narrow-band-imaging-and-chromoendoscopy-a-multicenter-randomized-controlled-trial
#17
Takashi Nagahama, Kenshi Yao, Noriya Uedo, Hisashi Doyama, Tetsuya Ueo, Kunihisa Uchita, Hideki Ishikawa, Takashi Kanesaka, Yasuhito Takeda, Kurato Wada, Kentaro Imamura, Hisatomi Arima, Toshio Shimokawa
BACKGROUND: Accurate delineation of tumor margins is necessary for curative resection of early gastric cancer (EGC). The objective of this multicenter, randomized, controlled study was to compare the accuracy with which magnifying narrow-band imaging (M-NBI) and indigo carmine chromoendoscopy delineate EGC margins. METHODS: Patients with EGC ≥ 10 mm undergoing endoscopic or surgical resection were enrolled. The oral-side margins of the lesions were first evaluated with conventional white-light endoscopy in both groups and then delineated by either chromoendoscopy or M-NBI...
February 13, 2018: Endoscopy
https://www.readbyqxmd.com/read/29438925/exploring-determinants-of-care-seeking-behaviour-of-oral-cancer-patients-in-india-a-qualitative-content-analysis
#18
Hemamalini Rath, Swikant Shah, Gaurav Sharma, Ekagrata Mishra
BACKGROUND: A major public health concern in India is the high morbidity and mortality rates of oral cancer because of late diagnosis. Among the several determinants of this late diagnosis, the most important is the healthcare-seeking behaviour of the oral cancer patients. The aim of this study was to explore the care-seeking behaviour and its determinants among oral cancer patients. METHODS: A face-to-face in-depth interview was conducted among 70 oral cancer patients using a semi-structured questionnaire, and qualitative content analysis of the results was performed...
February 10, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29436013/time-resolved-fluorescence-spectroscopy-for-the-diagnosis-of-oral-lichen-planus
#19
D Gorpas, P Davari, J Bec, M A Fung, L Marcu, D G Farwell, N Fazel
BACKGROUND: Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy. AIM: To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa. METHODS: In this pilot study, measurements of lesional and perilesional buccal and mouth floor mucosa were conducted in vivo with a TRFS system...
February 13, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29434152/whipple-s-disease-a-case-report-with-long-term-endoscopic-follow-up
#20
Hiroaki Saito, Junji Shiode, Shogen Ohya, Atsushi Yao, Shunsuke Saito, Masakuni Fujii, Mamoru Itoh, Shuhei Ishiyama, Akiko Fujiwara, Junichiro Nasu, Masao Yoshioka, Kazuhide Yamamoto
A 72-year-old man presented with anorexia and 15-kg weight loss over 3 years. Endoscopy revealed yellow, shaggy mucosa alternating with erythematous, eroded mucosa in the duodenum. Biopsy specimens showed massive infiltration of periodic acid-Schiff-positive macrophages in the lamina propria, consistent with Whipple's disease. The patient was treated with intravenous ceftriaxone for four weeks, followed by oral trimethoprim-sulfamethoxazole. His condition improved, and he gradually gained weight. Although the endoscopic findings improved with continuous trimethoprim-sulfamethoxazole administration, macrophage infiltration of the duodenal mucosa persisted...
February 9, 2018: Internal Medicine
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