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https://www.readbyqxmd.com/read/29693970/expression-of-cdk6-in-oral-squamous-cell-carcinomas
#1
Azadeh Andisheh-Tadbir, Mohammad Javad Ashraf, Naghmeh Jeiroodi
Background: CDK6 is the key factor in regulation of the cell cycle and essential for passage into the G1 phase. It also plays an important role in the development of various tumors. In this cross-sectional study expression of the CDK6 protein in oral squamous cell carcinoma (OSCC) and healthy oral mucosa of controls was assessed to determine relations with malignant transformation and clinicopathologic factors. Method: A total of 60 samples, 45 from OSCCs and 15 from healthy tissue, underwent immunohistochemistry for CDK6...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29692821/association-between-oral-lichen-planus-and-epstein-barr-virus-in-iranian-patients
#2
Matin Shariati, Mojgan Mokhtari, Aria Masoudifar
Background: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate the presence of Epstein-Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. Materials and Methods: The study was carried out on a case group including 38 tissue specimens of patients with histopathological confirmation of OLP and a control group including 38 samples of healthy mucosa...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29692595/unusual-presentation-of-renal-cell-carcinoma-a-rare-case-report
#3
Manjari Kishore, Devender Singh Chauhan, Shruti Dogra
Cutaneous and intraoral metastasis from any malignancy is not common. Cutaneous spread is usually noted in 5%-10% of high-grade malignancies, as in carcinoma breast, lung, colon, ovary, and malignant melanoma. Only 4.6% cases of cutaneous spread are from renal cell carcinoma (RCC). Intraoral spread from RCC is much rarer with an incidence of approximately 1% of all malignant oral tumors, noted sometimes in tongue, palate, buccal mucosa, gingiva, and lips. RCC is a highly aggressive tumor which requires early diagnosis for increasing the chance of cure...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29691259/transdermal-estradiol-for-the-management-of-refractory-uremic-bleeding
#4
Jimmy Gonzalez, Samantha Bryant, Evelyn R Hermes-DeSantis
PURPOSE: The efficacy and thrombogenicity of transdermal estradiol in the management of refractory uremic bleeding in adults are examined. SUMMARY: Platelet dysfunction from chronic kidney disease may induce uremic bleeding. This type of bleeding may involve the skin, oral and nasal mucosa, gingivae, respiratory system, and gastrointestinal or urinary tract. While the mainstay of treatment for uremic bleeding primarily involves dialysis and use of prohemostatic agents such as desmopressin and erythropoiesis-stimulating agents, certain patients may experience bleeding refractory to these interventions...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29690969/molecular-pathogenesis-of-chewable-tobacco
#5
Saeeda Baig, Zile Rubab, Wasfa Farooq
In Pakistan, extensive use of several precarious chewable tobacco formulations has made oral cancer the second leading malignancy. Selection of literature was done by a survey of studies published from 1990 to 2017 mainly, from PUBMED and few from other search engines, on naswar, gutka, areca nut and betel quid, which included published reviews, original articles and other data sources on chewable tobacco, its epidemiology, pathological implications, and psychological effects. These studies have revealed that the chemicals in these formulations bind and mutate DNA of oral mucosa through down regulating cellular repair pathways and upregulating genetic networks associated with pathogenesis...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29690702/-influencing-factors-for-keratinized-differentiation-of-keratinocytes
#6
X X Ding, X Li, J Wang, X M Gu, A Q Wu, Y M Zhou
Keratinized mucosa in oral cavity plays an important role in periodontal health. The defect of keratinized mucosa may increase the risks of complication of oral implant surgery and restoration. Graft of keratinized tissue and connective tissue are still the gold standard for treating keratinized mucosa defect now. The current research focus on how to modulate non-keratinized mucosa to highly-efficient and minimally-invasive keratinized mucosa. Keratinocytes are critical components of oral mucosa and its final differentiation into keratinized mucosa is controlled by the connective tissue microenvironment involving a variety of molecules and ions...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29690695/-comparative-analysis-of-methylation-profiles-in-tissues-of-oral-leukoplakia-and-oral-squamous-cell-carcinoma
#7
J Fu, Y Su, Y Liu, X Y Zhang
Objective: To compare the methylation profiles in tissues of oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC) with healthy tissues of oral mucosa, in order to identify the role of DNA methylation played in tumorigenesis. Methods: DNA samples extracted from tissues of 4 healthy oral mucosa, 4 OSCC and 4 OLK collected from patients of the Department of Oral Medicine, Capital Medical University School of Stomatology were examined and compared using Methylation 450 Bead Chip. The genes associated with differentially methylated CpG sites were selected for gene ontology (GO) analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29689703/clinical-biomarkers-for-cancer-recognition-and-prevention-a-novel-approach-with-optical-measurements
#8
Giuseppe Latini, Claudio De Felice, Alessandro Barducci, Lucia Dipaola, Mattia Gentile, Maria Grazia Andreassi, Mario Correale, Giorgio Bianciardi
Cancer is the most important cause of death worldwide, and early cancer detection is the most fundamental factor for efficacy of treatment, prognosis, and increasing survival rate. Over the years great effort has been devoted to discovering and testing new biomarkers that can improve its diagnosis, especially at an early stage. Here we report the potential usefulness of new, easily applicable, non-invasive and relatively low-cost clinical biomarkers, based on abnormalities of oral mucosa spectral reflectance and fractal geometry of the vascular networks in several different tissues, for identification of hereditary non-polyposis colorectal cancer carriers as well for detection of other tumors, even at an early stage...
April 6, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29688787/comparison-of-desflurane-and-propofol-at-equipotent-doses-in-combination-with-a-constant-rate-infusion-of-dexmedetomidine-on-global-and-peripheral-perfusion-and-oxygenation-in-horses
#9
Stephan Neudeck, Sabine B R Kästner, Liza Wittenberg-Voges, Karl Rohn, Klaus Hopster
OBJECTIVE To determine global and peripheral perfusion and oxygenation during anesthesia with equipotent doses of desflurane and propofol combined with a constant rate infusion of dexmedetomidine in horses. ANIMALS 6 warmblood horses. PROCEDURES Horses were premedicated with dexmedetomidine (3.5 μg•kg-1 , IV). Anesthesia was induced with propofol or ketamine and maintained with desflurane or propofol (complete crossover design) combined with a constant rate infusion of dexmedetomidine (7 μg•kg-1 •h-1 )...
May 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29687476/peptidylarginine-deiminase-is-involved-in-maintaining-the-cornified-oral-mucosa-of-rats
#10
S Arita, M Hatta, K Uchida, T Kita, K Okamura, T Ryu, H Murakami, R Sakagami, J Yamazaki
BACKGROUND AND OBJECTIVE: Epithelial cells derived from different regions exhibit marked differences in their differentiation capacity, allowing them to provide a suitable protective barrier. We aimed to clarify the role of peptidylarginine deiminase (PAD) in modifying the key epidermal proteins filaggrin (FLG) and keratin 1 (K1) during stratification of the rat palate and buccal mucosa. MATERIAL AND METHODS: We performed immunofluorescence, immunoblotting, PAD activity assays and 2-dimensional electrophoresis, and developed an organotypic culture model...
April 23, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29686919/grinspan-s-syndrome-a-rare-case-with-malignant-transformation
#11
Numan Kökten, Lokman Uzun, Ayşe Serap Karadağ, Tülay Zenginkinet, M Tayyar Kalcıoğlu
Aim: Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan's syndrome in 1966. We aim to present a case of Grinspan's syndrome with malignant transformation. Case Presentation: A 60-year-old man who presented with a ten-year history of OLP diagnosed clinically and histologically was referred to our otolaryngology department with a painless swallowing in the left buccal mucosa for 3 months...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29686791/lung-consolidation-as-a-rare-presentation-of-lymphoplasmacytic-lymphoma-with-extramedullary-waldenstr%C3%A3-m-s-macroglobulinemia
#12
Omar Abdulfattah, Ebad Ur Rahman, Bikash Bhattarai, Sumit Dahal, Zainab Alnafoosi, David Trauber, Danilo Enriquez, Frances Schmidt
Objectives : Lymphoplasmacytic lymphoma (LPL) is a mature B cell lymphoma that usually involves the bone marrow, spleen and lymph nodes. Extramedullary involvement, including the lung, is rarely reported. Case description : A 73-year-old female initially presented to our hospital complaining of productive cough of white-colour sputum for three weeks duration. She reported unintentional weight loss of ten pounds over the last five months. There was no history of haemoptysis, fever, night sweats, chills, recent infections or hospitalization...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29686771/oral-wound-healing-effects-of-acai-berry-water-extracts-in-rat-oral-mucosa
#13
Mi Hyun Kang, Bae-Hwan Kim
The objective of this study was to determine the oral wound healing effects of acai berry water extracts (ABWE) in rat oral mucosa. To estimate the anti-oxidative effects of ABWE, the contents of phenolic compounds, and DPPH (1,1-diphenyl-2-picryl hydrazyl) and ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) abilities were evaluated. Wound healing effects of ABWE were tested following 6-day exposure after induction of wound by applying 50% acetic acid to oral mucosa of Sprague-Dawley rats. Macroscopic and histopathological analyses were performed to determine wound healing effects of ABWE...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686705/intraoral-potentially-malignant-disorders-in-a-brazilian-oral-pathology-service-epidemiological-clinical-and-histopathological-findings
#14
Fernanda Weber Mello, Gilberto Melo, Maria Inês Meurer, Elena Riet Correa Rivero
The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD) in an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia (ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports. Histological diagnoses were collected from histopathological records. Among 208 IOPMD cases, 84.13% involved LKP; 11.1%, ELKP; and 4...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29683432/granular-cell-tumour-of-the-tongue-treated-by-radiofrequency-ablation
#15
Saverio Capodiferro, Angela Tempesta, Luisa Limongelli, Eugenio Maiorano, Gianfranco Favia
AIM: To report on a case of granular cell tumour occurring in the tongue surgically removed by surgical radiofrequency, with histological examination. MATERIAL OF STUDY: Discussion on the clinico-pathological characteristics of the granular cell tumour and the surgical treatment by surgical radiofrequency: the differential diagnosis is also discussed. RESULTS: Histological examination is mandatory for the final diagnosis. Surgical radiofrequency is an useful medical device to achieve good quality surgery with minimal post-operative course...
April 23, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29682214/head-and-neck-squamous-cell-carcinoma-and-its-correlation-with-human-papillomavirus-in-people-living-with-hiv-a-systematic-review
#16
REVIEW
Manuela Ceccarelli, Emmanuele Venanzi Rullo, Alessio Facciolà, Giordano Madeddu, Bruno Cacopardo, Rosaria Taibi, Francesco D'Aleo, Marilia Rita Pinzone, Isa Picerno, Michele di Rosa, Giuseppa Visalli, Fabrizio Condorelli, Giuseppe Nunnari, Giovanni Francesco Pellicanò
Over the last 20 years we assisted to an increase in the mean age of People Living with HIV and their comorbidities. Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. Despite their increasing incidence in HIV-positive people, mechanisms that lead to their development and progression are only partially understood. The aim of this review is to identify key data and factors about HPV-related head and neck squamous cell carcinoma in HIV-seropositive patients...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681940/variation-of-energy-in-photobiomodulation-for-the-control-of-radiotherapy-induced-oral-mucositis-a-clinical-study-in-head-and-neck-cancer-patients
#17
Cizelene do Carmo Faleiros Veloso Guedes, Silas Antonio Juvencio de Freitas Filho, Paulo Rogério de Faria, Adriano Mota Loyola, Robinson Sabino-Silva, Sérgio Vitorino Cardoso
Oral mucositis (OM) is a frequent and severe adverse effect of therapy against head and neck cancer. Photobiomodulation with the low-power laser is known to be effective against OM, but the diversity of protocols and the possibility of stimulating residual tumor cells are still obstacles. The present study aimed to compare two doses of laser energy delivered to the oral mucosa of patients under oncologic treatment for head and neck cancer, looking for differences in the control of mucositis, as well as in the frequency of tumoral recurrences...
2018: International Journal of Dentistry
https://www.readbyqxmd.com/read/29680851/lichenoid-lesions-of-the-upper-lip-a-retrospective-study-of-24-cases
#18
N Katsoulas, K Tosios, A Sklavounou-Andrikopoulou
BACKGROUND: Lichenoid lesions of the upper labial mucosa, without other oral or extraoral manifestations seem to be rare. The clinicopathologic features of 24 such cases are presented and the pertinent literature is reviewed. MATERIALS AND METHODS: 24 Caucasian patients that clinically presented lichenoid features on the upper labial mucosa, with or without lichenoid lesions on the adjacent gingiva, were included in the study. Clinical features were extracted from the patients records, while dental plaque/calculus accumulation and composite resin restorations of the adjacent teeth were recorded...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29679504/intraoral-frostbite-and-leidenfrost-effect
#19
Divya Vinayachandran, Saravanakarthikeyan
Intraoral frostbite as such, is an unusual occurrence. Careful literature review revealed rare cases of intraoral frostbite, attributed to intentional inhalational abuse of fluorinated hydrocarbons, dry ice, liquid nitrogen etc,.1,2 Hypothermal injuries of the gastric mucosa caused by ingestion of liquid nitrogen have been reported but none of these patients suffered from any direct injury affecting the oral mucosa.3 Here, we report the first case of intraoral frostbite causing injury to the oral mucosal tissues due to the direct contact of liquid nitrogen, highlighting the mechanism of the injury...
April 21, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29679067/psychological-stress-deteriorates-skin-barrier-function-by-activating-11%C3%AE-hydroxysteroid-dehydrogenase-1-and-the-hpa-axis
#20
Sung Jay Choe, Donghye Kim, Eun Jung Kim, Joung-Sook Ahn, Eun-Jeong Choi, Eui Dong Son, Tae Ryong Lee, Eung Ho Choi
Psychological stress (PS) increases endogenous glucocorticoids (GC) by activating the hypothalamic-pituitary-adrenal axis. The negative effects of GC on skin barrier function under PS have been well-established. However, endogenous GC can also be active when cortisone (inactive form) is converted to cortisol (active form) by 11β-hydroxysteroid dehydrogenase type I (11ß-HSD1) in the peripheral tissue. Here, we evaluated the changes in 11ß-HSD1 and barrier function under PS. Elevated 11ß-HSD1 in oral mucosa correlated with increased cortisol in the stratum corneum and deteriorated barrier function...
April 20, 2018: Scientific Reports
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