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https://www.readbyqxmd.com/read/28445215/promoting-learning-and-patient-care-through-shared-reflection-a-conceptual-framework-for-team-reflexivity-in-health-care
#1
Jan B Schmutz, Walter J Eppich
Health care teams are groups of highly skilled experts who may often form inexpert teams because of a lack of collective competence. Because teamwork and collaboration form the foundation of effective clinical practice, factors that promote collective competence demand exploration. The authors review team reflexivity (TR), a concept from psychology and management literatures, and how it could contribute to the collective competence of health care teams. TR captures a team's ability to reflect collectively on group objectives, strategies, goals, processes, and outcomes of past, current, and future performance to process key information and adapt accordingly...
April 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28444701/is-electrolyte-transfer-across-the-urothelium-important-ici-rs-2015
#2
REVIEW
Karen D McCloskey, Bahareh Vahabi, Christopher H Fry
AIMS: This article summarizes discussion at the International Consultation on Incontinence Research Society (ICI-RS) 2015 meeting of urine modification in the urinary tract by the urothelium. It considers the literature and proposes pertinent questions that need to be addressed to understand this phenomenon within a physiological context. METHODS: Following the ICI-RS meeting, publications in PubMed relating to urine modification in the renal pelvis, ureter, and bladder were reviewed...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28444532/the-utrecht-cohort-for-multiple-breast-cancer-intervention-studies-and-long-term-evaluation-umbrella-objectives-design-and-baseline-results
#3
D A Young-Afat, C H van Gils, H J G D van den Bongard, H M Verkooijen
PURPOSE: In oncology, RCTs are often beset by slow recruitment, limited generalizability, and strong preferences for interventions by patients and physicians. The cohort multiple randomized controlled trial (cmRCT) is an innovative design with the potential to overcome those challenges. In cmRCT, a prospective cohort serves as an infrastructure for multiple RCTs. We implemented cmRCT in a clinical breast cancer setting by creating UMBRELLA-a large prospective cohort of breast cancer and DCIS patients/survivors...
April 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28443634/a-unifying-mathematical-framework-for-experimental-tcr-pmhc-kinetic-constants
#4
Jose Faro, Mario Castro, Carmen Molina-París
Receptor binding and triggering are central in Immunology as T cells activated through their T cell receptors (TCR) by protein antigens orchestrate immune responses. In order to understand receptor-ligand interactions, many groups working with different experimental techniques and assays have generated a vast body of knowledge during the last decades. However, in recent years a type of assays, referred to as two-dimensional or membrane-to-membrane, has questioned our current understanding of the role of different kinetic constants (for instance, on- versus off-rate constants) on TCR-ligand interaction and subsequent T cell activation...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440923/ecotoxicity-testing-of-microplastics-considering-the-heterogeneity-of-physicochemical-properties
#5
Scott Lambert, Christian Scherer, Martin Wagner
"Microplastic" is an umbrella term that covers many particle shapes, sizes, and polymer types, and as such the physical and chemical properties of environmental microplastics will differ from the primary microbeads commonly used for ecotoxicity testing. In the present article, we discuss the physical and chemical properties of microplastics that are potentially relevant to their ecotoxicity, including particle size, particle shape, crystallinity, surface chemistry, and polymer and additive composition. Overall, there is a need for a structured approach to the testing of different properties to identify which are the most relevant drivers of microplastic toxicity...
May 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28432966/risk-for-eating-disorders-modulates-interpretation-bias-in-a-semantic-priming-task
#6
Kaylee Misener, Maya Libben
The current study used a semantic priming paradigm to investigate the presence of implicit interpretation biases for food and body shape words among 118 undergraduate females. Reaction times (RTs) were recorded while participants made lexical decisions (i.e., word vs. non-word judgments) to lexical targets that were preceded by negatively valenced eating disorder related (e.g., fat-PIZZA), eating disorder unrelated (e.g., party-PIZZA), or semantically unrelated (e.g., umbrella-PIZZA) prime words. Self-reported eating disorder traits were assessed using the Body Shape Questionnaire (BSQ-34), the Eating Attitudes Test (EAT-26), and the Eating Disorder Examination (EDE-Q 6...
April 19, 2017: Body Image
https://www.readbyqxmd.com/read/28431768/is-there-room-for-luminal-basal-urothelial-cell-population-quantification
#7
G R Passos, J A Camargo, K L Ferrari, G C Franch, A E Nowill, L O Reis
PURPOSE: Three cell layers compose the urothelium: basal, intermediate and luminal ("umbrella cells") and different diseases might arise from different cell populations. The aim of this study is to analyze the quantification ability of such cell populations by using four different protocols. METHODS: Twenty male rats (Wistar) were randomized in four groups of five animals: scraping, enzymatic 30, 45 and 60minutes. The cells were isolated, analyzed by flow cytometer and data processed by BD FACSDIVA™ software...
April 18, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28423829/ontological-realism-for-the-research-domain-criteria-for-mental-disorders
#8
Werner Ceusters, Mark Jensen, Alexander D Diehl
At the heart of the Research Domain Criteria for Mental Disorders is a matrix in which functional aspects of behavior are related to genotypic and (endo-)phenotypic research findings, and the various techniques through which they can been observed. The matrix is work in progress. As such it currently suffers from several shortcomings, the resolution of which, we contend, are essential to success of NIMH's goal of fostering translational science on mental disorders. Using well-established criteria for assessing the terminological and ontological quality of biomedical representations we identified the major problems to be (1) the abundant presence of terms that lack face value, (2) the absence of what the exact nature of the represented relationships are, and (3) referential imprecision with respect to the intended granularity of what the terms denote...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423211/-driving-to-the-edge-of-the-cliff-transgender-mental-health
#9
EDITORIAL
Russell Ashmore, Elizabeth Collier
Three years ago a member of our family disclosed that they were transgender. The umbrella term transgender refers to 'a significant minority of people whose gender expression or identity differs from societal expectations of their assigned sex at birth' (Bailey et al. 2014). We had not faced anything like this before and we quickly learnt that transgender issues provoke strong opinions and emotions. This article is protected by copyright. All rights reserved.
April 19, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28413429/falling-under-the-umbrella-cells-a-single-institutional-experience-and-literature-review-of-urothelial-carcinoma-presenting-as-a-primary-pancreatic-mass-on-endoscopic-ultrasound-guided-fine-needle-aspiration
#10
Michael Chambers, Konrad Krall, Shantel Hébert-Magee
Metastases to the pancreas are much less common than primary pancreatic lesions, and there are few reports in the literature of metastatic urothelial carcinoma (UC) found in the pancreas. We report two cases of metastatic UC mimicking a primary pancreatic lesion. Two female patients, aged 48 and 83 years, presented with isolated pancreatic lesions causing obstructive jaundice suspicious for pancreatic adenocarcinoma and underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with rapid on-site evaluation (ROSE)...
2017: CytoJournal
https://www.readbyqxmd.com/read/28406059/investigating-the-ion-dependence-of-the-first-unfolding-step-of-gtpase-associating-center-ribosomal-rna
#11
Hamed S Hayatshahi, Christina Bergonzo, Thomas E Cheatham
The interactions in the tertiary structure of a ribosomal RNA fragment in the GTPase Associating Center (GAC) have been experimentally studied, but the roles of the bound and diffuse cations in its folding pathway have not yet been fully elucidated. Melting experiments have shown that the temperature of the first of the two distinguishable transitions in the unfolding pathway of the GAC RNA can be regulated by altering the magnesium concentration, yet the physical interpretation of such ion-dependent effects on folding have not been clearly understood in spite of the availability of crystal structures that depict many GAC RNA-ion interactions...
April 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28400416/top-medical-centers-sign-on-to-single-irb-model
#12
(no author information available yet)
All 64 member institutions of the NIH's Clinical and Translational Science Awards program have agreed to a common framework for running multisite trials under the umbrella of just one Institutional Review Board. The NCI has long offered a centralized review board option. Come September, single Institutional Review Boards will be mandatory for all NIH-backed studies.
April 11, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28398987/predicting-risk-and-outcomes-for-frail-older-adults-an-umbrella-review-of-frailty-screening-tools
#13
João Apóstolo, Richard Cooke, Elzbieta Bobrowicz-Campos, Silvina Santana, Maura Marcucci, Antonio Cano, Miriam Vollenbroek-Hutten, Federico Germini, Carol Holland
BACKGROUND: A scoping search identified systematic reviews on diagnostic accuracy and predictive ability of frailty measures in older adults. In most cases, research was confined to specific assessment measures related to a specific clinical model. OBJECTIVES: To summarize the best available evidence from systematic reviews in relation to reliability, validity, diagnostic accuracy and predictive ability of frailty measures in older adults. INCLUSION CRITERIA POPULATION: Older adults aged 60 years or older recruited from community, primary care, long-term residential care and hospitals...
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28394803/hpv-negative-gastric-type-adenocarcinoma-in-situ-of-the-cervix-a-spectrum-of-rare-lesions-exhibiting-gastric-and-intestinal-differentiation
#14
Karen L Talia, Colin J R Stewart, Brooke E Howitt, Marisa R Nucci, W Glenn McCluggage
In recent years, a number of benign and malignant cervical glandular lesions exhibiting gastric differentiation have been described but premalignant gastric-type lesions have not been well characterized. We report a series of 9 cases of a rare form of cervical adenocarcinoma in situ (AIS) distinguished by gastric and sometimes intestinal differentiation and lack of association with human papillomavirus (HPV) infection. The lesions occurred in women aged 25 to 73 years (mean age 51 y). All cases were located at (or just proximal to) the cervical transformation zone and there was extension to the lower uterine segment in 3 cases, 2 of which also involved the endometrium...
April 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28391759/current-treatment-of-tracheoesophageal-fistula
#15
Changzhi Zhou, Yi Hu, Yang Xiao, Wen Yin
Tracheoesophageal fistulas (TEFs) often occur with esophageal or bronchial carcinoma. Currently, we rely on implantation of delicate devices, such as self-expanding and silicone stents, in the esophagus or trachea to cover the fistula and expand the stenosis in order to relieve patient pain. However, because each case is different, our approach may not be effective for every patient. Consequently, new devices and technology have emerged to address these situations, such as degradable stents, Amplatzer(®) devices, endobronchial one-way umbrella-shaped valves, and transplantation of mesenchymal stem cells...
April 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28389950/structure-of-the-mota-b-proton-channel
#16
Akio Kitao, Yasutaka Nishihara
Flagellar motors utilize the motive force of protons and other ions as an energy source. To elucidate the mechanisms of ion permeation and torque generation, it is essential to investigate the structure of the motor stator complex; however, the atomic structure of the transmembrane region of the stator has not been determined experimentally. We recently constructed an atomic model structure of the transmembrane region of the Escherichia coli MotA/B stator complex based on previously published disulfide cross-linking and tryptophan scanning mutations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28388088/revisiting-partition-in-hydrated-bilayer-systems
#17
João T S Coimbra, Pedro A Fernandes, Maria J Ramos
We discuss potential-of-mean force convergence issues involving the methods for generating starting structures of umbrella sampling simulations for the study of the water-bilayer permeation of drug-like compounds. We provide a proof of concept of the benefits of potential-energy modification methods, in particular the flooding technique, to enhance the sampling and improve the convergence of the potential-of-mean force. In addition, we also discuss how these potential modifiers could introduce the necessary bias to induce the correct description of other relevant internal degrees of freedom for the compounds, thus providing a more accurate description of the permeation process...
April 13, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28383599/assessment-of-knowledge-on-temporomandibular-disorders-among-mexican-dental-educators
#18
Irene A Espinosa, Edgar M Pérez, Yoly M Gonzalez, Alejandro Corona
Temporomandibular disorders (TMDs) is an umbrella term that embraces a group of musculoskeletal and neuromuscular conditions that involve the temporomandibular joints, muscles and all associated tissues. Because of the relatively high number of patients with TMDs in the population, instruction in this area of health care should be included on all dental curricula. Although levels of knowledge among dentists have been evaluated in several countries, they have not been in Mexico. This study evaluates the dental faculty's range of knowledge about TMD at five dental schools in Puebla, Mexico...
December 2016: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/28378291/vibrational-spectroscopic-techniques-to-assess-bone-quality
#19
REVIEW
E P Paschalis, S Gamsjaeger, K Klaushofer
Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment outcome is evaluated based mainly on routine clinical outcomes of bone mineral density (BMD) by DXA and biochemical markers, it is recognized that these two indicators, as valuable as they have proven to be in the everyday clinical practice, do not fully account for manifested bone strength. Thus, the term bone quality was introduced, to complement considerations based on bone turnover rates and BMD. Bone quality is an "umbrella" term that incorporates the structural and material/compositional characteristics of bone tissue...
April 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28377396/optimal-duration-of-dual-antiplatelet-therapy-following-percutaneous-coronary-intervention-protocol-for-an-umbrella-review
#20
Jesse Elliott, Shannon E Kelly, Zemin Bai, Wenfei Liu, Becky Skidmore, Michel Boucher, Derek Y F So, George A Wells
INTRODUCTION: Although dual antiplatelet therapy (DAPT) is routinely given to patients after percutaneous coronary intervention (PCI) with stenting, the optimal duration is unknown. Recent evidence indicates there may be benefits in extending the duration beyond 12 months but such decisions may increase the risk of bleeding. Our objective is to provide a comprehensive overview of the literature for clinicians and policymakers via an umbrella review assessing the optimal duration of DAPT...
April 4, 2017: BMJ Open
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