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https://www.readbyqxmd.com/read/29792997/risk-factors-for-low-back-pain-and-sciatica-an-umbrella-review
#1
REVIEW
P Parreira, C Maher, D Steffens, M Hancock, M Ferreira
BACKGROUND: Low back pain (LBP) is a highly prevalent condition and it is associated with significant disability and work absenteeism worldwide. A variety of environmental and individual characteristics have been reported to increase the risk of low back pain (LBP). To our knowledge, there has been no previous attempt to summarise the evidence from existing systematic reviews of risk factors for LBP and/or sciatica PURPOSE: to provide an overview of risk factors for LBP, we completed an umbrella review of the evidence from existing systematic reviews...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792313/one-gene-many-endocrine-and-metabolic-syndromes-pten-opathies-and-precision-medicine
#2
Lamis Yehia, Charis Eng
An average of 10% of all cancers (range 1-40%) are caused by heritable mutations and over the years, have become powerful models for precision medicine practice. Furthermore, such cancer predisposition genes for seemingly rare syndromes have turned out to help explain mechanisms of sporadic carcinogenesis and often inform normal development. The tumor suppressor PTEN encodes a ubiquitously expressed phosphatase that counteracts the PI3K/AKT/mTOR cascade - one of the most critical growth-promoting signaling pathways...
May 23, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29787443/old-data-new-concepts-integrating-indirect-effects-into-radiation-protection
#3
Carmel Mothersill, Colin Seymour
PURPOSE: To address the following key question, what are the consequences of nontargeted and delayed effects for linear nonthreshold models of radiation risk? This paper considers low-dose "indirect" or nontargeted effects and how they might impact radiation protection, particularly at the level of the environment. Nontargeted effects refer to effects in cells, tissues, or organisms that were not targeted by irradiation and that did not receive direct energy deposition. They include genomic instability and lethal mutations in progeny of irradiated cells and bystander effects in neighboring cells, tissues, or organisms...
July 2018: Health Physics
https://www.readbyqxmd.com/read/29785493/mindset-and-communication-barriers-in-the-diffusion-of-bariatric-surgery
#4
REVIEW
Daniel Gero, Bors Hulesch, Marco Bueter
PURPOSE OF REVIEW: Cumulating evidence is available to demonstrate the efficacy of bariatric surgery (BS) in achieving weight loss and optimizing comorbidities. However, currently, only a minority of eligible patients approaches bariatric centers. The underuse of BS can no longer be explained by the lack of evidence supporting its beneficial outcomes along with its favorable safety-profile, rather, by the supporting infrastructure, insurance coverage, and mindset of society, including potential patients and allied healthcare professionals...
May 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29785088/insight-into-resistance-mechanism-of-anaplastic-lymphoma-kinase-to-alectinib-and-jh-viii-157-02-caused-by-g1202r-solvent-front-mutation
#5
Han Wang, Yao Wang, Wentao Guo, Bin Du, Xiaobing Huang, Riping Wu, Baoyu Yang, Xiaoyan Lin, Yilan Wu
Background: Mutated anaplastic lymphoma kinase (ALK) drives the development of advanced non-small cell lung cancer (NSCLC). Most reported small-molecule inhibitors targeting the ALK domain do not display good inhibition of the G1202R solvent front mutation. The solvent front mutation was assumed to hinder drug binding. However, a different fact could be uncovered by the simulations reported in this study through a structural analog of alectinib (JH-VIII-157-02), which demonstrated potent effects against the G1202R mutation...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29781057/cardiovascular-disease-prevention-training-opportunities-the-challenges-and-future-directions
#6
REVIEW
Anum Saeed, Kaustubh Dabhadkar, Salim S Virani, Peter H Jones, Christie M Ballantyne, Vijay Nambi
PURPOSE: Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide, necessitating major efforts in prevention. This review summarizes the currently available training opportunities in CVD prevention for fellows-in-training (FITs) and residents. We also highlight the challenges and future directions for CVD prevention as a field and propose a structure for an inclusive CVD prevention training program. RECENT FINDINGS: At present, there is a lack of centralized training resources for FITs and residents interested in pursuing a career in CVD prevention...
May 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29776178/rare-behavior-of-growth-processes-via-umbrella-sampling-of-trajectories
#7
Katherine Klymko, Phillip L Geissler, Juan P Garrahan, Stephen Whitelam
We compute probability distributions of trajectory observables for reversible and irreversible growth processes. These results reveal a correspondence between reversible and irreversible processes, at particular points in parameter space, in terms of their typical and atypical trajectories. Thus key features of growth processes can be insensitive to the precise form of the rate constants used to generate them, recalling the insensitivity to microscopic details of certain equilibrium behavior. We obtained these results using a sampling method, inspired by the "s-ensemble" large-deviation formalism, that amounts to umbrella sampling in trajectory space...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29770591/surf-an-innovative-framework-in-biosecurity-and-animal-health-surveillance-evaluation
#8
Petra Muellner, Jonathan Watts, Paul Bingham, Mark Bullians, Brendan Gould, Anjali Pande, Tim Riding, Paul Stevens, Daan Vink, Katharina Dc Stärk
Surveillance for biosecurity hazards is being conducted by the New Zealand Competent Authority, the Ministry for Primary Industries (MPI) to support New Zealand's biosecurity system. Surveillance evaluation should be an integral part of the surveillance life cycle, as it provides a means to identify and correct problems and to sustain and enhance the existing strengths of a surveillance system. The surveillance evaluation Framework (SurF) presented here was developed to provide a generic framework within which the MPI biosecurity surveillance portfolio, and all of its components, can be consistently assessed...
May 16, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29768435/tuna-labels-matter-in-europe-mislabelling-rates-in-different-tuna-products
#9
Carmen G Sotelo, Amaya Velasco, Ricardo I Perez-Martin, Kristina Kappel, Ute Schröder, Véronique Verrez-Bagnis, Marc Jérôme, Rogério Mendes, Helena Silva, Stefano Mariani, Andrew Griffiths
Tuna fisheries and processing represent economic activities of paramount importance around the world. Most of these products are traded for human consumption and in general are highly demanded commodities. However, not all tuna products achieve the same market price, some consumers are willing to pay a huge amount of money for certain species (i.e. Japanese market for Bluefin tuna) while other species are rather affordable (i.e. Skipjack tuna), therefore mislabelling has been observed frequently. We collected and analysed 545 tuna samples in six European countries, including fresh, frozen and canned products, and we have investigated whether or not these products were correctly labelled under European and national legislations...
2018: PloS One
https://www.readbyqxmd.com/read/29766816/a-systematic-review-of-the-literature-of-the-three-related-disease-entities-cheilitis-granulomatosa-orofacial-granulomatosis-and-melkersson-rosenthal-syndrome
#10
Goetz Wehl, Markus Rauchenzauner
BACKGROUND AND OBJECTIVE: Melkersson Rosenthal syndrome (MRS) is a rare disorder of unknown etiology and comprises the triad: orofacial edema, recurrent facial paralysis and lingua plicata. In the current literature confusing heterogeneity exists, mixing together the historically grown terms cheilitis granulomatosa or granulomatous cheilitis, Melkersson Rosenthal syndrome and the umbrella term orofacial granulomatosis (OFG). METHODS: We provide a systematic review comprising all three disease entities of orofacial granulomatosis using the computerized database "Pubmed Medline" entering the key words "orofacial granulomatosis" (141 references), "Melkersson-Rosenthal syndrome" (207 references), "granulomatous cheilitis" or "cheilitis granulomatosa" (102 references) back to 1956...
May 14, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29764488/interventions-to-improve-physical-activity-among-socioeconomically-disadvantaged-groups-an-umbrella-review
#11
REVIEW
Melinda Craike, Glen Wiesner, Toni A Hilland, Enrique Garcia Bengoechea
BACKGROUND: People from socioeconomically disadvantaged population groups are less likely to be physically active and more likely to experience adverse health outcomes than those who are less disadvantaged. In this umbrella review we examined across all age groups, (1) the effectiveness of interventions to improve physical activity among socioeconomically disadvantaged groups, (2) the characteristics of effective interventions, and (3) directions for future research. METHODS: PubMed/MEDLINE and Scopus were searched up to May 2017 to identify systematic reviews reporting physical activity interventions in socioeconomically disadvantaged populations or sub-groups...
May 15, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29764145/nucleus-size-pinning-for-determination-of-nucleation-free-energy-barriers-and-nucleus-geometry
#12
Abhishek K Sharma, Fernando A Escobedo
Classical Nucleation Theory (CNT) has recently been used in conjunction with a seeding approach to simulate nucleation phenomena at small-to-moderate supersaturation conditions when large free-energy barriers ensue. In this study, the conventional seeding approach [J. R. Espinosa et al., J. Chem. Phys. 144, 034501 (2016)] is improved by a novel, more robust method to estimate nucleation barriers. Inspired by the interfacial pinning approach [U. R. Pedersen, J. Chem. Phys. 139, 104102 (2013)] used before to determine conditions where two phases coexist, the seed of the incipient phase is pinned to a preselected size to iteratively drive the system toward the conditions where the seed becomes a critical nucleus...
May 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29764113/soda-taxes-the-importance-of-analysing-policy-processes-comment-on-the-untapped-power-of-soda-taxes-incentivising-consumers-generating-revenue-and-altering-corporate-behaviours
#13
Yann Le Bodo, Philippe De Wals
Sarah A. Roache and Lawrence O. Gostin's recent editorial comprehensively presents soda taxation rationales from a public health perspective. While we essentially agree that soda taxes are gaining momentum, this commentary expands upon the need for a better understanding of the policy processes underlying their development and implementation. Indeed, the umbrella concept of soda taxation actually covers a diversity of objectives and mechanisms, which may not only condition the feasibility and acceptability of a proposal, but also alter its impact...
October 21, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29763303/design-and-synthesis-of-highly-potent-hiv-1-protease-inhibitors-containing-tricyclic-fused-ring-systems-as-novel-p2-ligands-structure-activity-studies-biological-and-x-ray-structural-analysis
#14
Arun K Ghosh, Prasanth R Nyalapatla, Satish Kovela, Kalapala Venkateswara Rao, Margherita Brindisi, Heather L Osswald, Masayuki Amano, Manabu Aoki, Johnson Agniswamy, Yuan-Fang Wang, Irene T Weber, Hiroaki Mitsuya
The design, synthesis, and biological evaluation of a new class of HIV-1 protease inhibitors containing stereochemically defined fused tricyclic polyethers as the P2 ligands and a variety of sulfonamide derivatives as the P2' ligands are described. A number of ring sizes and various substituent effects were investigated to enhance the ligand-backbone interactions in the protease active site. Inhibitors 5c and 5d containing this unprecedented fused 6-5-5 ring system as the P2 ligand, an aminobenzothiazole as the P2' ligand, and a difluorophenylmethyl as the P1 ligand exhibited exceptional enzyme inhibitory potency and maintained excellent antiviral activity against a panel of highly multidrug-resistant HIV-1 variants...
May 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29762311/mapping-the-implementation-of-evidence-based-nutritional-management-in-primary-health-care-settings-a-scoping-review-protocol
#15
Nara Leticia Zandonadi de Oliveira, Heloise Lima Fernandes Agreli, Karen Dos Santos Matsumoto, Marina Peduzzi
The objective of this scoping review is to systematically map and categorize the wide variety of interventions and programs that might be classified under the umbrella term "evidence-based nutritional management in primary healthcare". The development of this scoping review will provide a better understanding of how evidence-based nutritional management has been implemented by healthcare professionals in primary health care settings, especially of barriers and facilitators to implementing evidence-based nutritional management...
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29761020/tested-and-reported-executive-problems-in-children-and-youth-epilepsy
#16
Erik Hessen, Kristin Å Alfstad, Halvor Torgersen, Morten I Lossius
Objectives: Executive problems in children and youth with epilepsy influence their ability to handle important aspects of daily life activities. The present study sought to explore factors associated with executive problems for patients with epilepsy in this age group. Methods: The cohort consisted of 97 consecutive patients at the National Centre for Epilepsy in Norway, aged 10-19 years, with focal or genetic generalized epilepsy. All underwent tests of executive functions (D-KEFS), the Behavior Rating Inventory for Executive Function (BRIEF), and screening for psychiatric symptoms, using the Strengths and Difficulties Questionnaire (SDQ)...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29758112/novel-and-emerging-therapies-for-cholestatic-liver-diseases
#17
Jordan Goldstein, Cynthia Levy
While bile acids are important for both digestion and signaling, hydrophobic bile acids can be harmful especially when in high concentrations. Mechanisms for protection of cholangiocytes against bile acid cytotoxicity include negative feedback loops via farnesoid X nuclear receptor (FXR) activation, the bicarbonate umbrella, cholehepatic shunting and anti-inflammatory signaling, among others. By altering or overwhelming these defense mechanisms, cholestatic diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) can further progress to biliary cirrhosis, end-stage liver disease and death or liver transplantation...
May 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29747488/investigating-the-feasibility-of-targeted-next-generation-sequencing-to-guide-the-treatment-of-head-and-neck-squamous-cell-carcinoma
#18
Sun Min Lim, Sang Hee Cho, In Gyu Hwang, Jae Woo Choi, Hyun Chang, Myung-Ju Ahn, Keon Uk Park, Ji-Won Kim, Yoon Ho Ko, Hee Kyung Ahn, Byoung Chul Cho, Byung-Ho Nam, Sang Hoon Chun, Ji Hyung Hong, Jung Hye Kwon, Jong Gwon Choi, Eun Joo Kang, Tak Yun, Keun-Wook Lee, Joo-Hang Kim, Jin Soo Kim, Hyun Woo Lee, Min Kyoung Kim, Dongmin Jung, Ji Eun Kim, Bhumsuk Keam, Hwan Jung Yun, Sangwoo Kim, Hye Ryun Kim
Purpose: Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed to implement next-generation sequencing (NGS) in determining actionable targets to guide appropriate molecular targeted therapy in HNSCC patients. Materials and Methods: Ninety-three tumors and matched blood samples underwent targeted sequencing of 244 genes using the Illumina HiSeq 2500 platform with an average depth of coverage of greater than 1,000×...
May 9, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29741263/the-2017-who-update-on-mature-t-and-natural-killer-nk-cell-neoplasms
#19
REVIEW
E Matutes
Over the last decade, there has been a significant body of information regarding the biology of the lymphoid neoplasms. This clearly supports the need for updating the 2008 WHO (World Health Organization) classification of haematopoietic and lymphoid tumours. The 2017 WHO classification is not a new edition but an update and revision of the 4th edition. New provisional entities but not new definitive entities are included, and novel molecular data in most of the entities and changes in the nomenclature in few of them have been incorporated...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29740280/common-ribs-of-inhibitory-synaptic-dysfunction-in-the-umbrella-of-neurodevelopmental-disorders
#20
REVIEW
Rachel Ali Rodriguez, Christina Joya, Rochelle M Hines
The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale. These disorders are heterogeneous, yet they share common behavioral symptomatology as well as overlapping genetic contributors, including proteins involved in the formation, specialization, and function of synaptic connections. Advances may arise from bridging the current knowledge on synapse related factors indicated from both human studies in NDD populations, and in animal models...
2018: Frontiers in Molecular Neuroscience
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