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https://www.readbyqxmd.com/read/28930630/assessing-the-structure-and-stability-of-transmembrane-oligomeric-intermediates-of-an-%C3%AE-helical-toxin
#1
Rajat Desikan, Prabal K K Maiti, K Ganapathy Ayappa
Protein membrane interactions play an important role in our understanding of diverse phenomena ranging from membrane assisted protein aggregation to oligomerization and folding. Pore forming toxins (PFTs) form the primary vehicle for infection by several strains of bacteria. These proteins expressed in a water soluble form (monomers) bind to the target membrane (protomer) to form a transmembrane pore complex through a process of oligomerization. Based on the structure of the transmembrane domains, PFTs are broadly classified into β or α toxins...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28930556/osteoimmunology-the-nexus-between-bone-and-immune-system
#2
Hamid Y Dar, Zaffar Azam, Rajaneesh Anupam, Rajesh K Mondal, Rupesh K Srivastava
Osteoimmunology is an interdisciplinary research field which combines the existing fields of osteology (bone biology) and immunology under one umbrella. The observation that contributed enormously to the emergence of osteoimmunology as an independent field of investigation was the enhanced bone loss in various inflammatory bone diseases such as rheumatoid arthritis, osteoporosis and periodontitis. T helper cells (Th1, Th2, Treg and Th17) along with various other immune cells (B cells, DC, macrophages etc.) are actively involved in bone homeostasis...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28917368/improving-vasomotor-symptoms-psychological-symptoms-and-health-related-quality-of-life-in-peri-or-post-menopausal-women-through-yoga-an-umbrella-systematic-review-and-meta-analysis
#3
REVIEW
M Shepherd-Banigan, K M Goldstein, R R Coeytaux, J R McDuffie, A P Goode, A S Kosinski, M G Van Noord, D Befus, S Adam, V Masilamani, A Nagi, J W Williams
OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about possible harms. Thus, many women with VMS seek nonhormonal, nonpharmacologic treatment options. However, evidence to guide clinical recommendations is inconclusive. This study reviewed the effectiveness of yoga, tai chi and qigong on vasomotor, psychological symptoms, and HRQoL in peri- or post-menopausal women...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28906340/contemporary-approach-to-joint-hypermobility-and-related-disorders
#4
Marco Castori, Alan Hakim
PURPOSE OF REVIEW: Joint hypermobility is a common, although largely ignored physical sign. Joint hypermobility is often asymptomatic but may be a feature of an underlying genetic disorder with systemic manifestations. The present article presents a comprehensive approach to considering joint hypermobility and clinically related issues in children and adults. RECENT FINDINGS: Ehlers-Danlos syndrome (EDS) is an umbrella term for various Mendelian connective tissue disorders sharing joint hypermobility, skin hyperextensibility, and tissue fragility...
September 12, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28903120/opening-the-black-box-of-cognitive-behavioural-case-management-in-clients-with-ultra-high-risk-for-psychosis
#5
Jessica A Hartmann, Patrick D McGorry, Stefanie J Schmidt, G Paul Amminger, Hok Pan Yuen, Connie Markulev, Gregor E Berger, Eric Y H Chen, Lieuwe de Haan, Ian B Hickie, Suzie Lavoie, Meredith J McHugh, Nilufar Mossaheb, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Miriam R Schäfer, Monika Schlögelhofer, Stefan Smesny, Andrew Thompson, Swapna Kamal Verma, Alison R Yung, Barnaby Nelson
BACKGROUND: Cognitive-behavioural therapy (CBT) is the first-choice treatment in clients with ultra-high risk (UHR) for psychosis. However, CBT is an umbrella term for a plethora of different strategies, and little is known about the association between the intensity and content of CBT and the severity of symptomatic outcome. METHODS: A sample of 268 UHR participants received 6 months of CBT with case management (CBCM) in the context of the multi-centre NEURAPRO trial with monthly assessments of attenuated psychotic symptoms (APS)...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28900361/developing-a-stoma-acceptance-questionnaire-to-improve-motivation-to-adhere-to-enterostoma-self-care
#6
REVIEW
A Bagnasco, R Watson, M Zanini, G Catania, G Aleo, L Sasso
INTRODUCTION: In stoma care, patient education is often weak in terms of improving patients' level of acceptance of living with a stoma. Self-care educational interventions in enterostomal patients, which according to Orem's Theory should take into account these patients' specific needs, require instruments that measure patients' stoma acceptance to improve motivation based on the resumption of activities they used to carry out before having a stoma. The aim of the study was to develop an instrument that measures the level of stoma acceptance to improve motivation to adhere to enterostoma self-care...
June 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28899670/definition-pathogenesis-and-management-of-that-cursed-dyspepsia
#7
REVIEW
Pramoda Koduru, Malcolm Irani, Eamonn M M Quigley
Dyspepsia is an umbrella term used to encompass a number of symptoms thought to originate from the upper gastrointestinal tract. These symptoms are relatively non-specific; not surprisingly, therefore, a myriad of conditions may present with any one or a combination of these symptoms. Therein lies the clinician's first challenge: detecting the minority who may have a potentially life-threatening disorder, such as gastric cancer, from a population whose symptoms are, for the most part, considered functional in origin...
September 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28899099/accurately-modeling-the-conformational-preferences-of-nucleosides
#8
Mihai Burai Patrascu, Elise Malek-Adamian, Masad J Damha, Nicolas Moitessier
Sugar puckering of nucleosides impacts nucleic acid structures, and hence their biological function. Similarly, nucleoside en-zyme inhibitors may adopt different conformations affecting their binding affinity, DNA incorporation and excision rates. As a result, significant efforts have been made to develop nucleo-side analogues adopting specific conformations to improve bioactivity and pharmacokinetic profiles of the corresponding nucleoside-containing drugs. Understanding and ultimately predicting these conformational preferences would significantly help the design of more effective structures...
September 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28898465/polar-electrode-bridged-electroluminescent-displays-2d-sensors-remotely-communicating-optically
#9
Xiuru Xu, Dan Hu, Lijia Yan, Shaoli Fang, Clifton Shen, Yueh-Lin Loo, Yuan Lin, Carter S Haines, Na Li, Anvar A Zakhidov, Hong Meng, Ray H Baughman, Wei Huang
A novel geometry for electroluminescent devices, which does not require transparent electrodes for electrical input, is demonstrated, theoretically analyzed, and experimentally characterized. Instead of emitting light through a conventional electrode, light emission occurs through a polar liquid or solid and input electrical electrodes are coplanar, rather than stacked in a sandwich configuration. This new device concept is scalable and easily deployed for a range of modular alternating-current-powered electroluminescent light sources and light-emitting sensing devices...
September 12, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28895919/nafld-is-there-anything-new-under-the-sun
#10
EDITORIAL
Amedeo Lonardo, Giovanni Targher
Nonalcoholic fatty liver disease (NAFLD) is an "umbrella" definition that encompasses a spectrum of histological liver changes ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) with/without fibrosis, "cryptogenic" cirrhosis, and hepatocellular carcinoma (HCC), occurring in a dysmetabolic milieu, though in the absence of excessive alcohol consumption and other competing etiologies of chronic liver disease [1].[...].
September 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28894982/severe-depression-more-common-in-patients-with-ductal-carcinoma-in-situ-than-early-stage-invasive-breast-cancer-patients
#11
M L Gregorowitsch, H J G D van den Bongard, D A Young-Afat, J P Pignol, C H van Gils, A M May, H M Verkooijen
PURPOSE: Ductal carcinoma in situ (DCIS) is associated with an excellent prognosis; historical studies have shown similar levels of psychological distress in patients with DCIS and with early-stage invasive breast cancer (early-IBC). It is suggested that these results might have led to better patient education about prognosis after DCIS. This study reports the current levels of anxiety, depression, and health-related quality of life (HRQoL) in DCIS and early-IBC patients. METHODS: DCIS (n = 89) and early-IBC patients, T1-2N0, (n = 361) were selected from the UMBRELLA breast cancer cohort...
September 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28891182/rare-disease-registries-a-call-to-action
#12
Paul Lacaze, Nicole Millis, Megan Fookes, Yvonne Zurynski, Adam Jaffe, Matthew Bellgard, Ingrid Winship, John McNeil, Alan H Bittles
When registries collect accurate clinical data over time, they can act as fundamental support structures for patients and their families and powerful cost-effective instruments to support clinical trials and translational research to improve quality of care, quality of life and survival. Registries are critical for rare diseases (RD) with low prevalence and propensity for variation in treatment and outcomes. Rare Voices Australia is leading a call for action to the research and clinical community to prioritise RD data collection and develop an integrated RD Registry strategy for Australia...
September 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28886456/broccoli-shaped-biosensor-hierarchy-for-electrochemical-screening-of-noradrenaline-in-living-cells
#13
Mohammed Y Emran, Moataz Mekawy, Naeem Akhtar, Mohamed A Shenashen, Islam M El-Sewify, Ahmed Faheem, Sherif A El-Safty
Monitoring and determination of ultra-trace concentrations of monoamine neurotransmitter such as noradrenaline (NA) in living cells with simple, sensitive and selective assays are significantly interesting. We design NA-electrode sensing system based on C-, N-doped NiO broccoli-like hierarchy (CNNB). The spherical broccoli-head umbrella architectures associated with nano-tubular arrangements enabled to tailor NA biosensor design. The homogenous doping and anisotropic dispersion of CN nanospheres along the entire NB head nanotubes lead to creating of abundant electroactive sites in the interior tubular vessels and outer surfaces for ultrasensitive detection of NA in living cells such as PC12...
August 31, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28880355/-mental-health-as-a-front-line-service-for-bewildered-persons
#14
C L Mulder, J van Weeghel, A Wierdsma, J Zoeteman, A Schene
'Bewildered persons' have often been in the news over the last few years. There has been much discussion about the meaning of the term 'bewildered persons', the number of people involved, the way the problem should be tackled and the role of the mental health services.<br/> AIM: To look critically at the term 'bewildered persons' and to discuss the suspected increase in numbers and the role of mental health services.<br/> METHOD: Review and discussion of the relevant literature relating to 'bewildered persons' which has been published in the last 25 years...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28877499/h4-tails-potentially-produce-the-diversity-in-the-orientation-of-two-nucleosomes
#15
Hisashi Ishida, Hidetoshi Kono
Histone tails play an important role in internucleosomal interaction and chromatin compaction. To understand how the H4 tails are involved in the internucleosomal interaction, an adaptively biased molecular dynamics simulation of 63 models of two stacked nucleosomes, each with the H4 tails in different locations, was carried out. This simulation generated a variety of orientations of the separated nucleosomes depending on the formation of the H4 tail bridge between the H4 tails and the DNA of the neighboring nucleosomes...
September 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28877008/definitions-and-statistical-properties-of-master-protocols-for-personalized-medicine-in-oncology
#16
Lindsay A Renfro, Sumithra J Mandrekar
Within the field of cancer research, discovery of biomarkers and genetic mutations that are potentially predictive of treatment benefit are motivating a paradigm shift in how cancer clinical trials are conducted. In this review, we provide an overview of the class of trials known as "master protocols", including basket trials, umbrella trials, and platform trials. For each, we describe standardized terminology, provide a motivating example with modeling details and decision rules, and discuss statistical advantages and limitations...
September 6, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28875878/facilitating-access-to-adolescent-sexual-and-reproductive-health-services-through-legislative-reform-lessons-from-the-south-african-experience
#17
A Strode, Z Essack
South Africa (SA) has progressive legislation enabling adolescents to access various sexual- and reproductive-health services (SRH) independently, without consent from parents or legal guardians. This article reviews the SA legislative framework for adolescent access to SRH interventions. It outlines the five approaches adopted in current legislation to address adolescents' capacity to independently consent to specified health interventions, based on age, capacity and public policy requirements, or combinations thereof...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28871206/gold-nanoparticles-approach-to-detect-chondroitin-sulphate-and-hyaluronic-acid-urothelial-coating
#18
Gabriella Guelfi, Valentina Stefanetti, Danilo Zampini, Oommen P Oommen, Gabriele Brecchia, Cecilia Dall'Aglio, Rolando Arcelli, Giovanni Cochetti, Andrea Boni, Ettore Mearini
This study investigated the location of hyaluronic acid (HA)- and chondroitin sulphate (CS)-coated gold nanoparticles in rabbit bladder and evaluated gene expression of CD44, RHAMM and ICAM-1 receptors involved in HA and CS transport into the cell. Gold nanoparticles were synthesised by reduction of gold salts with HA or CS to form HA-AuNPs and CS-AuNPs. Bladder samples were incubated with CS-AuNPs and HA-AuNPs or without glycosaminoglycans. Transmission electron microscopy, optic microscopy and scanning electron microscopy were used to determine the location of the synthesised AuNPs...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870809/efficient-potential-of-mean-force-calculation-from-multiscale-simulations-solute-insertion-in-a-lipid-membrane
#19
Roberto Menichetti, Kurt Kremer, Tristan Bereau
The determination of potentials of mean force for solute insertion in a lipid membrane by means of all-atom molecular dynamics simulations is often hampered by sampling issues. Recently, a multiscale method has been proposed to leverage the conformational ensemble of a lower-resolution model as starting point for higher resolution simulations. In this work, we analyze the efficiency of this method by comparing its predictions for propanol insertion into a lipid membrane against conventional atomistic umbrella sampling simulation results...
September 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28870066/simulation-studies-on-the-lipid-interaction-and-conformation-of-novel-drug-delivery-pseudopeptidic-polymers
#20
Shuzhe Wang, Fernando Bresme
A class of pseudopeptides based on poly(lysine iso-phthalamide) backbone have emerged as promising drug delivery candidates due to their pH activated membrane disruption ability. In order to gain molecular understanding on these novel polymeric species, we have constructed force field parameters and simulated the behaviours of polymers with and without phenylalanine grafted as side chains at conditions compatible with different pH. The free energy changes upon polymer permeation through membrane were calculated using the umbrella sampling technique...
September 4, 2017: Journal of Physical Chemistry. B
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