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https://www.readbyqxmd.com/read/28644076/a-novel-surgical-approach-to-avian-femorotibiotarsal-luxation-repair
#1
Anna E McRee, Thomas N Tully, Javier G Nevarez, Julia Sumner, Anderson Favero da Cunha
A 3-month-old male umbrella cockatoo (Cacatua alba) was presented because of acute non-weight-bearing lameness of the right leg. Marked soft tissue swelling was present around the femorotibiotarsal (stifle) joint, and the radiographic diagnosis was right medial femorotibiotarsal subluxation. Surgical management was elected, and the stifle joint was approached via a lateral parapatellar incision. Joint exploration revealed damage to the lateral meniscus, tendon of origin of the cranial tibial muscle, and cranial cruciate ligament...
June 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28641569/a-review-on-defects-of-dendritic-cells-in-common-variable-immunodeficiency
#2
Laleh Sharifi, Naeimeh Tavakolinia, Fatemeh Kiaee, Nima Rezaie, Monireh Mohsenzadegan, Mansoureh Shariat, Reza Yazdani, Abbas Mirshafiey, Asghar Aghamohammadi, Gholamreza Azizi
BACKGROUND AND OBJECTIVES: Common variable immunodeficiency (CVID) is the most important primary that is associated with clinical complications including recurrent infections, malignancy and autoimmune diseases. The genetic cause of CVID is mostly unknown and only a few genetic causes are identified. The various options are proposed for determining the etiology of CVID patients, such as T- and B-cell defects, Toll-like receptors (TLRs) impairments, altered cytokine production as well as blemished dendritic cells (DCs)...
June 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28639255/necessity-and-feasibility-of-improving-mental-health-services-in-china-a-systematic-qualitative-review
#3
REVIEW
Xudong Zhao, Liang Liu, Chengping Hu, Fazhan Chen, Xirong Sun
It has been nearly 40 years since the reform and opening up of Mainland China. The mental health services system has developed rapidly as a part of the profound socioeconomic changes that ensued. However, its development has not been as substantial as other areas of medical care. For the current qualitative systematic review, we searched databases, including China Biology Medicine disc, Weipu, China National Knowledge Infrastructure, Wanfang digital periodical full text data, China's important newspaper full text database, China Statistical Yearbook database, etc...
June 22, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/28639035/mitigation-of-pedestrian-heat-stress-using-parasols-in-a-humid-subtropical-region
#4
Shinichi Watanabe, Jin Ishii
Concerns over heat illness have been an increasing social problem in humid subtropical regions. One measure for avoiding excessive heat stress in hot outdoor environments is the use of parasols or umbrellas. The advantage of parasols is that they are a mobile and inexpensive way to provide personal shade outdoors. The objectives of this study were to compare the wet-bulb globe temperature (WBGT) under parasols and at an unshaded point as a reference, and to quantify the reduction in WBGT from the use of parasols in a humid subtropical region...
June 21, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28636909/electric-field-induced-protein-translocation-via-a-conformational-transition-in-secdf-an-md-study
#5
Emel Ficici, Daun Jeong, Ioan Andricioaei
SecDF is an important component of the Sec protein translocation machinery embedded in the bacterial membrane, which is associated with many functions, such as stabilizing other Sec translocon components within the membrane, maintaining the transmembrane (TM) potential, and facilitating the ATP-independent stage of the translocation mechanism. Related studies suggest that SecDF undergoes functionally important conformational changes that involve mainly its P1-head domain and that these changes are coupled with the proton motive force (Δp)...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28628510/effectiveness-of-vocational-rehabilitation-on-work-participation-in-adults-with-musculoskeletal-disorders-an-umbrella-review-protocol
#6
Lyndsay Alexander, Kay Cooper, Dawn Mitchell, Colin MacLean
The objective of this umbrella review is to determine the effectiveness of vocational rehabilitation on work participation in working age adults with musculoskeletal disorders (MSDs). More specifically the review will address the following questions.
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28627112/asymptotic-distribution-of-%C3%A2-auc-nris-and-idi-based-on-theory-of-u-statistics
#7
Olga V Demler, Michael J Pencina, Nancy R Cook, Ralph B D'Agostino
The change in area under the curve (∆AUC), the integrated discrimination improvement (IDI), and net reclassification index (NRI) are commonly used measures of risk prediction model performance. Some authors have reported good validity of associated methods of estimating their standard errors (SE) and construction of confidence intervals, whereas others have questioned their performance. To address these issues, we unite the ∆AUC, IDI, and three versions of the NRI under the umbrella of the U-statistics family...
June 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28621954/van-der-waals-contribution-to-the-relative-stability-of-aqueous-zn-2-coordination-states
#8
Manoj Ducher, Fabio Pietrucci, Etienne Balan, Guillaume Ferlat, Lorenzo Paulatto, Marc Blanchard
Many properties of aqueous cations depend on their coordination state. However, the lack of long-range order and the dynamic character of aqueous solutions make it difficult to obtain information beyond average coordination parameters. A thorough understanding of the molecular scale environment of aqueous cations usually requires a combination of experimental and theoretical approaches. In the case of Zn(2+), significant discrepancies occur among theoretical investigations based on first-principles molecular-dynamics (FPMD) or free-energy calculations, although experimental data consistently point to a dominant hexaaquo-zinc complex (Zn[H2O]6)(2+) in pure water...
June 16, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28620735/meningocele-manqu%C3%A3-a-comprehensive-review-of-this-enigmatic-finding-in-occult-spinal-dysraphism
#9
REVIEW
Cameron Schmidt, Ellie Bryant, Joe Iwanaga, Rod J Oskouian, W Jerry Oakes, R Shane Tubbs
The term meningocele manqué (MM) was coined in 1972 to describe a broad range of surgical findings characterized by intradural bands tethering neural structures to the dorsal dura. Over the following decades, reports continued to lump intradural tethering bands associated with a variety of comorbidities under the umbrella term MM. In more recent years, disorders previously called MM have been identified as embryologically distinct and were reclassified. While this sectioning continues, there remains a set of intradural tethering disorders for which no better term than MM exists...
June 15, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28619067/design-and-initial-implementation-of-the-who-fp-umbrella-project-to-strengthen-contraceptive-services-in-the-sub-saharan-africa
#10
Rita Kabra, Moazzam Ali, James Kiarie
BACKGROUND: Strengthening contraceptive services in sub Saharan Africa is critical to achieve the FP 2020 goal of enabling 120 million more women and girls to access and use contraceptives by 2020 and the Sustainable Development Goals (SDG) targets of universal access to sexual and reproductive health (SRH) services including family planning by 2030. METHOD: The World Health Organization (WHO) and partners have designed a multifaceted project to strengthen health systems to reduce the unmet need of contraceptive and family planning services in sub Saharan Africa...
June 15, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28614588/architecture-of-the-paracellular-channels-formed-by-claudins-of-the-blood-brain-barrier-tight-junctions
#11
Flaviyan Jerome Irudayanathan, Nan Wang, Xiaoyi Wang, Shikha Nangia
Tight junctions (TJs) are key players in determining tissue-specific paracellular permeability across epithelial and endothelial membranes. Claudin proteins, the primary determinants of TJs structure and functionality, assemble in paracellular spaces to form channels and pores that are charge and size selective. Here, using molecular dynamics (MD) simulations, we elucidate the molecular assembly of claudin-3 and claudin-5 proteins of blood-brain barrier TJs. Despite having a high degree of sequence and structural similarity, these two claudins form different types of cis-interactions...
June 14, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28610559/sclerosing-mesenteritis-and-mesenteric-panniculitis-clinical-experience-and-radiological-features
#12
Lisa Nyberg, Jan Björk, Peter Björkdahl, Olle Ekberg, Klas Sjöberg, Lina Vigren
BACKGROUND: Sclerosing mesenteritis (SM) is sometimes used as an umbrella-term for idiopathic inflammatory conditions in the mesentery. Mesenteric panniculitis (MP) is a radiological finding and its relation to clinical SM is not fully understood. The aims of this study were to determine whether any correlation could be found between the radiological findings and the clinical disease course. METHODS: Patients observed due to idiopathic inflammation of the mesentery were identified...
June 13, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28607668/future-perspectives-on-nonmedical-prescribing
#13
REVIEW
Derek Stewart, Tesnime Jebara, Scott Cunningham, Ahmed Awaisu, Abdulrouf Pallivalapila, Katie MacLure
Many countries have implemented nonmedical prescribing (NMP) and many others are scoping prescribing practices with a view to developing NMP. This paper provides a future perspective on NMP in light of findings of an umbrella review of aspects of NMP. This is followed by coverage of the Scottish Government strategy of pharmacist prescribing and finally, consideration of two key challenges. The review identified seven systematic reviews of influences on prescribing decision-making, processes of prescribing, and barriers and facilitators to implementation...
June 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28601024/an-umbrella-review-of-meta-analyses-of-interventions-to-improve-maternal-outcomes-for-teen-mothers
#14
Lee SmithBattle, Deborah G Loman, Chutima Chantamit-O-Pas, Joanne Kraenzle Schneider
The purpose of this study was to perform an umbrella review of meta-analyses of intervention studies designed to improve outcomes of pregnant or parenting teenagers. An extensive search retrieved nine reports which provided 21 meta-analyses analyses. Data were extracted by two reviewers. Methodological quality was assessed using the AMSTAR Instrument. Most effect sizes were small but high quality studies showed significant outcomes for reduced low birth weight (RR = 0.60), repeat pregnancies/births (OR = 0...
June 7, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28598896/assessing-pathophysiology-of-cancer-anorexia
#15
Alessandro Laviano, Angela Koverech, Marilia Seelaender
PURPOSE OF REVIEW: Cancer anorexia is a negative prognostic factor and is broadly defined as the loss of the interest in food. However, multiple clinical domains contribute to the phenotype of cancer anorexia. The characterization of the clinical and molecular pathophysiology of cancer anorexia may enhance the efficacy of preventive and therapeutic strategies. RECENT FINDINGS: Clinical trials showed that cancer anorexia should be considered as an umbrella encompassing different signs and symptoms contributing to appetite disruption in cancer patients...
June 8, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28595233/-solitary-fibrous-tumor-originating-from-the-visceral-pleura-presenting-an-extrapleural-sign-report-of-a-case
#16
Kyosuke Matsunaga, Yusuke Takanashi, Shogo Tajima, Takamitsu Hayakawa, Hiroshi Neyatani
We report a case of solitary fibrous tumor (SFT) originating from the visceral pleura, which presented an extrapleural sign on chest computed tomography (CT) and magnetic resonance imaging (MRI). A 44-year-old woman presented at our hospital for a growing mass visible in chest X-rays. Chest CT and MRI detected a 27×12 mm lesion on the intrathoracic side of the right 3rd intercostal space. The extrapleural signs strongly suggested the tumor to be chest wall origin. However, the tumor was found to be pedunculate with an umbrella-like appearance locating on the visceral pleura of the lung...
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28592419/serum-uric-acid-levels-and-multiple-health-outcomes-umbrella-review-of-evidence-from-observational-studies-randomised-controlled-trials-and-mendelian-randomisation-studies
#17
REVIEW
Xue Li, Xiangrui Meng, Maria Timofeeva, Ioanna Tzoulaki, Konstantinos K Tsilidis, P A Ioannidis, Harry Campbell, Evropi Theodoratou
Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.Design Umbrella review.Data sources Medline, Embase, Cochrane Database of Systematic Reviews, and screening of citations and references.Eligibility criteria Systematic reviews and meta-analyses of observational studies that examined associations between SUA level and health outcomes, meta-analyses of randomised controlled trials that investigated health outcomes related to SUA lowering treatment, and Mendelian randomisation studies that explored the causal associations of SUA level with health outcomes...
June 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28591602/configurational-preference-of-the-glutamate-receptor-ligand-binding-domain-dimers
#18
Michael Yonkunas, Maiti Buddhadev, Jose C Flores Canales, Maria G Kurnikova
Ionotropic glutamate receptors are a family of tetrameric ion channels with functional states consisting of nonconducting, conducting, and desensitized states that are starting to become well characterized by electrophysiological and biophysical studies. However, the structure and relative energetics of these states beyond the general structure of the receptor are still not well understood. It is known that the interface between monomeric subunits of the tetramer plays a major role in distinguishing these functional states...
June 6, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28591598/mechanism-of-ntp-binding-to-the-active-site-of-t7-rna-polymerase-revealed-by-free-energy-simulation
#19
Shaogui Wu, Laicai Li, Quan Li
In genetic transcription, molecular dynamic details and energetics of NTP binding to the active site of RNA polymerase (RNAP) are poorly understood. In this article, we investigated the NTP binding process in T7 RNAP using all-atom MD simulation combined with the umbrella sampling technique. Based on our simulations, a two-step mechanism was proposed to explain NTP binding: first, substrate NTP in aqueous solution, which carries a magnesium ion, diffuses through a secondary channel of RNAP to attain a pore region, where it undergoes conformational changes to give a correct orientation; next, the NTP establishes initial basepairing contacts with the template nucleoside (TN)...
June 6, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28580451/a-case-with-late-onset-of-ambiguous-genitalia
#20
Soraya Saleh Gargari, Faezeh Azizi, Nasrin Saleh, Mir Davood Omrani
BACKGROUND: Ambiguous genitalia is an uncommon situation that happens between 1 and 2 per every 1000 live births and falls under the umbrella diagnosis of disorders of sexual development. CASE: In this article, we report a case of male pseudohermaphroditism with ambiguous genitalia. The proband was a 12 yr old girl without any uterus or ovarian tissues. Karyotype of the case is 46, XY. Genes involved in sexual differentiation such as AR, SRD5A2, LH, LHR, FSH, 17 B HSD and SRY genes were sequenced in both directions...
March 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
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