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https://www.readbyqxmd.com/read/28231590/endotypes-in-chronic-rhinosinusitis-biomarkers-based-on-a-mechanistic-insight-for-targeted-treatment
#1
Martin Wagenmann, Kathrin Scheckenbach, Adam M Chaker
Chronic rhinosinusitis is an umbrella term for several phenotypes and mechanistically distinct inflammatory diseases of the nose and the paranasal sinuses affecting around 11% of the population in Europe and the USA. Approximately 20% of the patients present with uncontrolled disease despite adequate treatment, and revision surgery is common. While a clinical characterization alone does not improve treatment results, novel but expensive biologics have increasingly become available, but they require a better understanding of the mechanism...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28228693/health-benefits-of-dietary-whole-grains-an-umbrella-review-of-meta-analyses
#2
REVIEW
Marc P McRae
OBJECTIVE: The purpose of this study is to review the effectiveness of the role of whole grain as a therapeutic agent in type 2 diabetes, cardiovascular disease, cancer, and obesity. METHODS: An umbrella review of all published meta-analyses was performed. A PubMed search from January 1, 1980, to May 31, 2016, was conducted using the following search strategy: (whole grain OR whole grains) AND (meta-analysis OR systematic review). Only English language publications that provided quantitative statistical analysis on type 2 diabetes, cardiovascular disease, cancer, and weight loss were retrieved...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28225151/cytopathologic-differential-diagnosis-of-low-grade-urothelial-carcinoma-and-reactive-urothelial-proliferation-in-bladder-washings-a-logistic-regression-analysis
#3
Ebru Cakir, Ulku Kucuk, Emel Ebru Pala, Ozlem Sezer, Rahmi Gokhan Ekin, Ozgur Cakmak
Conventional cytomorphologic assessment is the first step to establish an accurate diagnosis in urinary cytology. In cytologic preparations, the separation of low-grade urothelial carcinoma (LGUC) from reactive urothelial proliferation (RUP) can be exceedingly difficult. The bladder washing cytologies of 32 LGUC and 29 RUP were reviewed. The cytologic slides were examined for the presence or absence of the 28 cytologic features. The cytologic criteria showing statistical significance in LGUC were increased numbers of monotonous single (non-umbrella) cells, three-dimensional cellular papillary clusters without fibrovascular cores, irregular bordered clusters, atypical single cells, irregular nuclear overlap, cytoplasmic homogeneity, increased N/C ratio, pleomorphism, nuclear border irregularity, nuclear eccentricity, elongated nuclei, and hyperchromasia (p ˂ 0...
February 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28225102/stability-of-reverse-micelles-in-rare-earth-separation-a-chemical-model-based-on-a-molecular-approach
#4
Yushu Chen, Magali Duvail, Philippe Guilbaud, Jean-François Dufrêche
Molecular complexes formed in the organic phase during solvent extraction may self-assemble as reverse micelles, and therefore induce a supramolecular organization of this phase. In most of the cases, water molecules play an essential role in the organization of this non polar medium. The aim of this work is to investigate the speciation of the aggregates formed in the organic phase during solvent extraction, and especially to assess their stability as a function of the number of water molecules included in their polar core...
February 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28224993/dynamical-barrier-and-isotope-effects-in-the-simplest-substitution-reaction-via-walden-inversion-mechanism
#5
Zhiqiang Zhao, Zhaojun Zhang, Shu Liu, Dong H Zhang
Reactions occurring at a carbon atom through the Walden inversion mechanism are one of the most important and useful classes of reactions in chemistry. Here we report an accurate theoretical study of the simplest reaction of that type: the H+CH4 substitution reaction and its isotope analogues. It is found that the reaction threshold versus collision energy is considerably higher than the barrier height. The reaction exhibits a strong normal secondary isotope effect on the cross-sections measured above the reaction threshold, and a small but reverse secondary kinetic isotope effect at room temperature...
February 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28223307/next-generation-systematic-reviews-prospective-meta-analysis-individual-level-data-networks-and-umbrella-reviews
#6
EDITORIAL
John Ioannidis
No abstract text is available yet for this article.
February 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28220544/prospective-purification-and-characterization-of-m%C3%A3-ller-glia-in-the-mouse-retina-regeneration-assay
#7
Patrick Schäfer, Mike O Karl
Reactive gliosis is an umbrella term for various glia functions in neurodegenerative diseases and upon injury. Specifically, Müller glia (MG) in some species readily regenerate retinal neurons to restore vision loss after insult, whereas mammalian MG respond by reactive gliosis-a heterogeneous response which frequently includes cell hypertrophy and proliferation. Limited regeneration has been stimulated in mammals, with a higher propensity in young MG, and in vitro compared to in vivo, but the underlying processes are unknown...
February 21, 2017: Glia
https://www.readbyqxmd.com/read/28211063/gating-energetics-of-a-voltage-dependent-k-channel-pore-domain
#8
Greg Starek, J Alfredo Freites, Simon Bernèche, Douglas J Tobias
We used targeted molecular dynamics, informed by experimentally determined inter-atomic distances defining the pore region of open and closed states of the KvAP voltage-gated potassium channel, to generate a gating pathway of the pore domain in the absence of the voltage-sensing domains. We then performed umbrella sampling simulations along this pathway to calculate a potential of mean force that describes the free energy landscape connecting the closed and open conformations of the pore domain. The resulting energetic landscape displays three minima, corresponding to stable open, closed, and intermediate conformations with roughly similar stabilities...
February 16, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28207329/longitudinal-patterns-and-predictors-of-depression-trajectories-related-to-the-2014-occupy-central-umbrella-movement-in-hong-kong
#9
Michael Yuxuan Ni, Tom Kung Leung Li, Herbert Hei Man Pang, Brandford Ho Yeung Chan, Ichiro Kawachi, Kasisomayajula Viswanath, Catherine Mary Schooling, Gabriel Matthew Leung
OBJECTIVES: To examine the longitudinal patterns and predictors of depression trajectories before, during, and after Hong Kong's 2014 Occupy Central/Umbrella Movement. METHODS: In a prospective study, between March 2009 and November 2015, we interviewed 1170 adults randomly sampled from the population-representative FAMILY Cohort. We used the Patient Health Questionnaire-9 to assess depressive symptoms and probable major depression. We investigated pre-event and time-varying predictors of depressive symptoms...
February 16, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28206839/from-studying-the-rain-to-studying-the-umbrella-mental-health-and-well-being-of-veterinary-medical-students-and-graduates
#10
Susan M Rhind, Andrew Grant
No abstract text is available yet for this article.
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28205291/molecular-dynamics-simulation-study-of-the-stay-or-leave-problem-for-two-magnesium-ions-in-gene-transcription
#11
Shaogui Wu
Two magnesium ions play important roles in nucleotide addition cycle (NAC) of gene transcription. However, at the end of each NAC, why does one ion stay in the active site while the other ion leaves with product pyrophosphate (PPi )? This problem still remains obscure. In the present work, we studied the problem using all-atom molecular dynamics (MD) simulation combined with steered molecular dynamics (SMD) and umbrella sampling (US) simulation methods. Our simulations reveal that although both ions are located in the active site after chemistry, their detailed positions are not symmetrical, leading to their different forces from surrounding groups...
February 16, 2017: Proteins
https://www.readbyqxmd.com/read/28199125/one-pot-synthesis-of-%C3%AE-branched-n-acylamines-via-titanium-mediated-condensation-of-amides-aldehydes-and-organometallics
#12
Chunhui Dai, Julien Genovino, Bruce M Bechle, Matthew S Corbett, Chan Woo Huh, Colin R Rose, Jianmin Sun, Joseph S Warmus, David C Blakemore
A three-component, titanium-mediated synthesis of α-branched N-acylamines from commercial or readily accessible amides, aldehydes, and organometallic reagents is reported. The transformation proceeds under mild reaction conditions and tolerates a variety of functional groups (including nitrile, carbamate, olefin, basic amine, furan, and other sensitive heteroaromatics) to generate a large umbrella of α-branched N-acylamine products in high yields. The operationally practical procedure enables the use of this method in parallel chemical synthesis, a valuable feature that can facilitate the screening of bioactive molecules by medicinal chemists...
February 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28197949/the-impact-of-next-generation-sequencing-on-the-diagnosis-and-treatment-of-epilepsy-in-paediatric-patients
#13
REVIEW
Davide Mei, Elena Parrini, Carla Marini, Renzo Guerrini
Next-generation sequencing (NGS) has contributed to the identification of many monogenic epilepsy syndromes and is favouring earlier and more accurate diagnosis in a subset of paediatric patients with epilepsy. The cumulative information emerging from NGS studies is rapidly changing our comprehension of the relations between early-onset severe epilepsy and the associated neurological impairment, progressively delineating specific entities previously gathered under the umbrella definition of epileptic encephalopathies, thereby influencing treatment choices and limiting the most aggressive drug regimens only to those conditions that are likely to actually benefit from them...
February 14, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28195473/a-local-order-parameter-based-method-for-simulation-of-free-energy-barriers-in-crystal-nucleation
#14
Neda Khanjari, Hossein Eslami, Florian Müller-Plathe
While global order parameters have widely been used, as reaction coordinates, in nucleation and crystallization studies, their use in nucleation studies is claimed to have a serious drawback. In this work, a local order parameter is introduced, as a local reaction coordinate, to drive the simulation from the liquid to solid phase and vice versa. This local order parameter holds information regarding the order in the first and the second shell neighbors of a particle and has different well-defined values for local crystallites and disordered neighborhoods, but is insensitive to the type of the crystal structure...
February 14, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28187425/computational-lipidomics-and-lipid-bioinformatics-filling-in-the-blanks
#15
Josch Pauling, Edda Klipp
Lipids are highly diverse metabolites of pronounced importance in health and disease. While metabolomics is a broad field under the omics umbrella that may also relate to lipids, lipidomics is an emerging field which specializes in the identification, quantification and functional interpretation of complex lipidomes. Today, it is possible to identify and distinguish lipids in a high-resolution, high-throughput manner and simultaneously with a lot of structural detail. However, doing so may produce thousands of mass spectra in a single experiment which has created a high demand for specialized computational support to analyze these spectral libraries...
December 22, 2016: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28185799/exploring-single-nucleotide-polymorphism-snp-microsatellite-ssr-and-differentially-expressed-genes-in-the-jellyfish-rhopilema-esculentum-by-transcriptome-sequencing
#16
Yunfeng Li, Zunchun Zhou, Meilin Tian, Yi Tian, Ying Dong, Shilei Li, Weidong Liu, Chongbo He
In this study, single nucleotide polymorphism (SNP), microsatellite (SSR) and differentially expressed genes (DEGs) in the oral parts, gonads, and umbrella parts of the jellyfish Rhopilema esculentum were analyzed by RNA-Seq technology. A total of 76.4 million raw reads and 72.1 million clean reads were generated from deep sequencing. Approximately 119,874 tentative unigenes and 149,239 transcripts were obtained. A total of 1,034,708 SNP markers were detected in the three tissues. For microsatellite mining, 5088 SSRs were identified from the unigene sequences...
February 6, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28177494/statistical-controversies-in-clinical-research-basket-trials-umbrella-trials-and-other-master-protocols-a-review-and-examples
#17
L A Renfro, D J Sargent
No abstract text is available yet for this article.
January 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28177208/minimally-invasive-hysterectomy-for-benign-indications-an-update
#18
C Emi Bretschneider, Karl Jallad, Marie F Paraiso
Hysterectomy is one of the most commonly performed surgeries worldwide. Indication for hysterectomy is most often benign, which includes conditions such as prolapse, abnormal uterine bleeding, fibroids and pelvic pain. A broad range of surgical approaches exists for hysterectomy, ranging from open to minimally invasive techniques. Under this minimally invasive umbrella, the following techniques are included: vaginal hysterectomy (VH), laparoscopic hysterectomy (LH), and variations of those two techniques, such as laparoscopicassisted vaginal hysterectomy (LAVH), robotic-assisted hysterectomy (RH), laparo-endoscopic single-site laparoscopic hysterectomy (LESS), mini-laparoscopic hysterectomy (MLH), and natural orifice transluminal endoscopic surgery (NOTES) hysterectomy...
February 8, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28161836/what-we-learned-with-recent-network-meta-analyses-on-atherosclerosis-prevention-and-treatment
#19
REVIEW
Arturo Giordano, Mariangela Peruzzi, Antonino G M Marullo, Giacomo Frati, Sebastiano Sciarretta, Giovanni Napolitano, Giuseppe Biondi-Zoccai
PURPOSE OF REVIEW: The management of atherosclerosis requires a complex integration of the knowledge on its pathophysiology, patient values, and the synthesis of the global scientific evidence informing on its prevention and treatment. Novel statistical methods such as umbrella reviews and network meta-analyses (NMAs) offer a unique opportunity for integrating different sources of evidence stemming from randomized controlled trials (RCTs) or internally valid observational studies. We aimed to provide an updated perspective on the most important contributions of recent network meta-analyses on atherosclerosis prevention and treatment...
February 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28153584/assessing-blood-flow-microvasculature-erythema-and-redness-in-hypertrophic-scars-a-cross-sectional-study-showing-different-features-that-require-precise-definitions
#20
M E H Jaspers, C M Stekelenburg, J M Simons, K M Brouwer, M Vlig, E van den Kerckhove, E Middelkoop, P P M van Zuijlen
BACKGROUND: In hypertrophic scar assessment, laser Doppler imaging (LDI), colorimetry and subjective assessment (POSAS) can be used to evaluate blood flow, erythema and redness, respectively. In addition, the microvasculature (i.e. presence of microvessels) can be determined by immunohistochemistry. These measurement techniques are frequently used in clinical practice and/or in research to evaluate treatment response and monitor scar development. However, until now it has not been tested to what extent the outcomes of these techniques are associated, whilst the outcome terms are frequently used interchangeably or replaced by the umbrella term 'vascularization'...
January 30, 2017: Burns: Journal of the International Society for Burn Injuries
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