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https://www.readbyqxmd.com/read/28098047/vitamin-a-deficiency-suppresses-fish-immune-function-with-differences-in-different-intestinal-segments-the-role-of-transcriptional-factor-nf-%C3%AE%C2%BAb-and-p38-mitogen-activated-protein-kinase-signalling-pathways
#1
Li Zhang, Lin Feng, Wei-Dan Jiang, Yang Liu, Pei Wu, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
The present study investigated the effects of dietary vitamin A on immune function in the proximal intestine (PI), mid intestine (MI) and distal intestine (DI) of young grass carp (Ctenopharyngodon idella). Fish were fed graded levels of dietary vitamin A for 10 weeks, and then a challenge test using an injection of Aeromonas hydrophila was conducted for 14 d. The results showed that, compared with the optimum vitamin A level, vitamin A deficiency significantly decreased fish growth performance, increased enteritis morbidity, decreased intestinal innate humoral immune response and aggravated intestinal inflammation...
January 18, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28093230/gastrin-releasing-peptide-induces-monocyte-adhesion-to-vascular-endothelium-by-upregulating-endothelial-adhesion-molecules
#2
Mi-Kyoung Kim, Hyun-Joo Park, Yeon Kim, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Bae
Gastrin-releasing peptide (GRP) is a neuropeptide that plays roles in various pathophysiological conditions including inflammatory diseases in peripheral tissues; however, little is known about whether GRP can directly regulate endothelial inflammatory processes. In this study, we showed that GRP promotes the adhesion of leukocytes to human umbilical vein endothelial cells (HUVECs) and the aortic endothelium. GRP increased the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by activating nuclear factor-κB (NF-κB) in endothelial cells...
January 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28088644/tert-butyl-hydroperoxide-t-bhp-induced-apoptosis-and-necroptosis-in-endothelial-cells-roles-of-nox4-and-mitochondrion
#3
Wenwen Zhao, Haitao Feng, Wen Sun, Kang Liu, Jin-Jian Lu, Xiuping Chen
Oxidative stress causes endothelial death while underlying mechanisms remain elusive. Herein, the pro-death effect of tert-butyl hydroperoxide (t-BHP) was investigated with low concentration (50μM) of t-BHP (t-BHPL) and high concentration (500μM) of t-BHP (t-BHPH). Both t-BHPL and t-BHPH induced endothelial cell death was determined. T-BHPL induced caspase-dependent apoptosis and reactive oxygen species (ROS) generation, which was inhibited by N-acetyl-L-cysteine (NAC). Furthermore, NADPH oxidase inhibitor diphenyleneiodonium (DPI), NOX4 siRNA, and NOX4 inhibitor GKT137831 reduced t-BHPL-induced ROS generation while mitochondrial respiratory chain inhibitors rotenone (Rot), 2-thenoyltrifluoroacetone (TTFA), and antimycin A (AA) failed to do so...
January 5, 2017: Redox Biology
https://www.readbyqxmd.com/read/28087833/dysregulation-of-map-kinase-signaling-pathways-including-p38mapk-sapk-jnk-and-erk1-2-in-cultured-rat-cerebellar-astrocytes-exposed-to-diphenylarsinic-acid
#4
Takayuki Negishi, Mami Matsumoto, Yayoi Kobayashi, Mikiya Kojima, Fumika Sakaguchi, Kazuaki Takahata, Tomoko Kanehira, Rina Arakaki, Yohei Aoyama, Hikari Yoshida, Rena Yamada, Nobutaka Sumiyoshi, Tomoko Tashiro, Seishiro Hirano, Kenji Yoshida, Kazunori Yukawa
Diphenylarsinic acid (DPAA) was a major compound found in the arsenic poisoning incident that occurred in Kamisu, Ibaraki, Japan in 2003. People exposed to DPAA via contaminated well water suffered from several neurological disorders, including cerebellar symptoms. We previously reported that DPAA induces cellular activation in cultured rat cerebellar astrocytes, dose-dependent promotion of cell growth (low DPAA), cell death (high DPAA), and increased phosphorylation of mitogen-activated protein (MAP) kinases (p38MAPK, SAPK/JNK, and ERK1/2)...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28081233/differences-in-inflammatory-response-induced-by-two-representatives-of-clades-of-the-pandemic-st258-klebsiella-pneumoniae-clonal-lineage-producing-kpc-type-carbapenemases
#5
Giuseppe Castronovo, Ann Maria Clemente, Alberto Antonelli, Marco Maria D'Andrea, Michele Tanturli, Eloisa Perissi, Sara Paccosi, Astrid Parenti, Federico Cozzolino, Gian Maria Rossolini, Maria Gabriella Torcia
ST258-K. pneumoniae (ST258-KP) strains, the most widespread multidrug-resistant hospital-acquired pathogens, belong to at least two clades differing in a 215 Kb genomic region that includes the cluster of capsule genes. To investigate the effects of the different capsular phenotype on host-pathogen interactions, we studied representatives of ST258-KP clades, KKBO-1 and KK207-1, for their ability to activate monocytes and myeloid dendritic cells from human immune competent hosts. The two ST258-KP strains strongly induced the production of inflammatory cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28077289/vitamin-d3-protects-against-a%C3%AE-peptide-cytotoxicity-in-differentiated-human-neuroblastoma-sh-sy5y-cells-a-role-for-s1p1-p38mapk-atf4-axis
#6
Federica Pierucci, Mercedes Garcia-Gil, Alessia Frati, Francesca Bini, Maria Martinesi, Eleonora Vannini, Marco Mainardi, Federico Luzzati, Paolo Peretto, Matteo Caleo, Elisabetta Meacci
Besides its classical function of bone metabolism regulation, 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3), acts on a variety of tissues including the nervous system, where the hormone plays an important role as neuroprotective, antiproliferating and differentiating agent. Sphingolipids are bioactive lipids that play critical and complex roles in regulating cell fate. In the present paper we have investigated whether sphingolipids are involved in the protective action of 1,25(OH)2D3. We have found that 1,25(OH)2D3 prevents amyloid-β peptide (Aβ(1-42)) cytotoxicity both in differentiated SH-SY5Y human neuroblastoma cells and in vivo...
January 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28073674/inhibition-of-invasion-by-n-trans-feruloyloctopamine-via-akt-p38mapk-and-emt-related-signals-in-hepatocellular-carcinoma-cells
#7
Zhong-Tian Bai, Zheng-Rong Wu, Li-Li Xi, Xun Li, Peng Chen, Fu-Qiang Wang, Wen-Bo Meng, Wen-Ce Zhou, Xin-An Wu, Xiao-Jun Yao, Min Zhang
N-trans-feruloyloctopamine (FO) isolated from Garlic skin was identified as the primary antioxidant constituents, however, the effect of which on HCC invasion is still unclear. Herein, the FO was synthesized and its antitumor activities were evaluated in HCC cell lines. Cellular functional analyses have revealed that the reformed FO owns strong abilities of inhibiting cell proliferation and invasion in HCC cells. Molecular data have further showed that FO could significantly decrease the phosphorylation levels of Akt and p38 MAPK...
December 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28064069/immunization-with-leishmania-donovani-protein-disulfide-isomerase-dna-construct-induces-th1-and-th17-dependent-immune-response-and-protection-against-experimental-visceral-leishmaniasis-in-balb-c-mice
#8
Ajay Amit, Vijayamahantesh, Manas R Dikhit, Ashish Kumar Singh, Vikash Kumar, Shashi S Suman, Ashu Singh, Akhilesh Kumar, Ajit Kumar Thakur, Vidyanand Ravi Das, Pradeep Das, Sanjiva Bimal
In the present study, the efficacy of Leishmania donovani protein disulfide isomerase (LdPDI) as a DNA vaccine was evaluated in BALB/C mice. Mice immunized with the LdPDI-DNA construct were found to be the most immuno-reactive, as the construct induced higher T-cell proliferation. The increased T-cell proliferation was associated with a substantial rise in Th1 and Th17+ CD4 cell response and triggered a higher proportion of CD8+ T cells for the release of interferon-gamma along with a reduced splenic parasite load on Days20 and 60 post challenge (PC)...
January 5, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28061318/hepatitis-b-surface-antigen-promotes-the-invasion-of-hepatitis-b-virus-related-hepatocellular-carcinoma-cells-by-upregulation-of-toll-like-receptor-2
#9
Shan Cheng, Bin Zhang, Ji-Ying Du, Yu-Hong Jin, Hai-Yang Lang, Li-Hua Zeng
Hepatitis B virus (HBV) infection is one of the major risk factors leading to the development of hepatocellular carcinoma (HCC). Hepatitis B surface antigen (HBsAg) plays a pivotal role in HBV-related HCC pathogenesis, and Toll-like receptor (TLR) 2 is also considered to mediate tumor progression. However, the interaction between HBsAg and TLR2 in HCC progression remains unclear. Thus, the aim of the study was to explore the effect of HBsAg-TLR2 pathway on growth and invasion of HBV-related HCC cells and examine the potential mechanisms been involved...
January 6, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28059455/acetoacetate-induces-hepatocytes-apoptosis-by-the-ros-mediated-mapks-pathway-in-ketotic-cows
#10
Xiliang Du, Zhen Shi, Zhicheng Peng, Chenxu Zhao, Yuming Zhang, Zhe Wang, Xiaobing Li, Guowen Liu, Xinwei Li
Dairy cows with ketosis are characterized by oxidative stress, hepatic damage and hyperketonemia. Acetoacetate (AA) is the main component of ketone bodies in ketotic cows, and is associated with the above pathological process. However, the potential mechanism was not illuminated. Therefore, the aim of this study was to investigate the mechanism of AA-induced hepatic oxidative damage in ketotic cows. Compared with healthy cows, ketotic cows exhibited severe oxidative stress and hepatic damage. Moreover, the extent of hepatic damage and oxidative stress had a positive relationship with the AA levels...
January 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28057160/-glabridin-reduces-lipopolysaccharide-induced-lung-injury-in-rats-by-inhibiting-p38-mitogen-activated-protein-kinase-extracellular-regulated-protein-kinases-signaling-pathway
#11
L P Zhang, J G Li
Objective: To investigate whether glabridin has a beneficial effect on lipopolysaccharide (LPS) induced acute respiratory distress syndrome (ARDS) in rats, and to explore the possible underlying mechanisms. Methods: Thirty-two Wistar rats were randomly assigned into control group, model group (LPS group), glabridin group (GLA group), and ulinastatin group (UTI group), with 8 rats in each group. ARDS rat model was reproduced by intraperitoneal injection of LPS (10 mg/kg). The rats in the control group received an equal volume of normal saline at the same times...
December 27, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28054206/the-effect-of-sinomenine-in-diabetic-neuropathic-pain-mediated-by-the-p2x3-receptor-in-dorsal-root-ganglia
#12
Shenqiang Rao, Shuangmei Liu, Lifang Zou, Tianyu Jia, Shanhong Zhao, Bing Wu, Zhihua Yi, Shouyu Wang, Yun Xue, Yun Gao, Changshui Xu, Guilin Li, Hong Xu, Chunping Zhang, Shangdong Liang
Type 2 diabetes mellitus (T2DM) accounts for more than 90% of all cases of diabetes mellitus (DM). Diabetic neuropathic pain (DNP) is a common complication of T2DM. Sinomenine is a natural bioactive component extracted from the Sinomenium acutum and has anti-inflammatory effects. The aim of our study was to investigate the effects of sinomenine on DNP mediated by the P2X3 receptor in dorsal root ganglia (DRG). The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in T2DM rats were lower than those of control rats...
January 4, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28039487/glabridin-attenuates-lipopolysaccharide-induced-acute-lung-injury-by-inhibiting-p38mapk-erk-signaling-pathway
#13
Li-Peng Zhang, Yan Zhao, Guo-Juan Liu, Da-Gang Yang, Yi-Huan Dong, Li-Hua Zhou
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a complication caused by pulmonary and/or external factors. In this study, we investigated the protective mechanisms of glabridin in lipopolysaccharide (LPS) induced ARDS in rats. RESULTS: GLA treatment at dose of 30 mg/kg decreased LPS-induced lung W/D ratio and alleviated evident lung histopathological changes. Expressions of TNF-α and IL-18 were suppressed by GLA in plasma. The levels of SPA, MDA and NO in lung were down-regulated significantly in groups administrated with GLA...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28024684/non-pathogenic-pemphigus-foliaceus-pf-igg-acts-synergistically-with-a-directly-pathogenic-pf-igg-to-increase-blistering-by-p38mapk-dependent-desmoglein-1-clustering
#14
Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, Masayuki Amagai, Ken Shiraishi, Yuji Shirakata, John R Stanley, Akira Ishiko
BACKGROUND: Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs). OBJECTIVE: To investigate how pathogenic and non-pathogenic anti-Dsg1 Abs contribute to blister formation in PF. METHODS: Using organ-cultured human skin, we compared the effect of a single pathogenic anti-Dsg1 IgG mAb, a single non-pathogenic anti-Dsg1 IgG mAb, and their mixture on blister formation as analyzed by histology, subcellular localization of IgG deposits and desmosomal proteins by confocal microscopy, and desmosomal structure by electron microscopy...
December 12, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28010122/lysyl-oxidase-induces-vascular-oxidative-stress-and-contributes-to-arterial-stiffness-and-abnormal-elastin-structure-in-hypertension-role-of-p38mapk
#15
Sonia Martínez-Revelles, Ana Belen Garcia-Redondo, Mª Soledad Avendaño, Saray Varona, Teresa Palao, Mar Orriols, Fernanda R Roque, Ana Fortuño, Rhian M Touyz, Jose Martínez-Gonzalez, Mercedes Salaices, Cristina Rodríguez, Ana María Briones
AIMS: Vascular stiffness, structural elastin abnormalities and increased oxidative stress are hallmarks of hypertension. Lysyl oxidase (LOX) is an elastin cross-linking enzyme that produces H<sub>2</sub>O<sub>2</sub> as by-product. We addressed the interplay between LOX, oxidative stress, vessel stiffness and elastin. RESULTS: Angiotensin II (Ang II)-infused hypertensive mice and spontaneously hypertensive rats (SHR) showed increased vascular LOX expression and stiffness and abnormal elastin structure...
December 23, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28007785/p38mapk-builds-a-hyaluronan-cancer-niche-to-drive-lung-tumorigenesis
#16
Anna Brichkina, Thomas Bertero, Hui Mun Loh, Nguyet Thi Minh Nguyen, Alexander Emelyanov, Sidwell Rigade, Marius Ilie, Paul Hofman, Cedric Gaggioli, Dmitry V Bulavin
Expansion of neoplastic lesions generates the initial signal that instigates the creation of a tumor niche. Nontransformed cell types within the microenvironment continuously coevolve with tumor cells to promote tumorigenesis. Here, we identify p38MAPK as a key component of human lung cancer, and specifically stromal interactomes, which provides an early, protumorigenic signal in the tissue microenvironment. We found that lung cancer growth depends on short-distance cues produced by the cancer niche in a p38-dependent manner...
December 1, 2016: Genes & Development
https://www.readbyqxmd.com/read/28003970/effects-of-resveratrol-on-arpe-19-cell-proliferation-and-migration-via-regulating-the-expression-of-proliferating-cell-nuclear-antigen-p21-p27-and-p38mapk-mmp-9
#17
Xiao-Ning Hao, Wen-Jie Wang, Jian Chen, Qing Zhou, Yi-Xin Qu, Xiao-Yong Liu, Wei Xu
AIM: To explore whether resveratrol (Res) can inhibit human retinal pigment epithelial cell (ARPE-19 cell) proliferation and migration, and to research the molecular mechanisms. METHODS: ARPE-19 cells were pretreated with various concentrations at 0, 50, 100, 150, 200 and 300 µmol/L of Res, and with 0 µmol/L Res as the control for 24, 48 and 72h. The cell proliferation, apoptosis and migration were measured with cell counting kit-8 (CCK-8), flow cytometry, and wound-healing and Transwell assays, respectively...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27988394/insights-on-wood-combustion-generated-proinflammatory-ultrafine-particles-ufp
#18
Emanuela Corsini, Senem Ozgen, Angela Papale, Valentina Galbiati, Giovanni Lonati, Paola Fermo, Lorenza Corbella, Gianluigi Valli, Vera Bernardoni, Manuela Dell'Acqua, Silvia Becagli, Donatella Caruso, Roberta Vecchi, Corrado L Galli, Marina Marinovich
This study aimed to collect, characterize ultrafine particles (UFP) generated from the combustion of wood pellets and logs (softwood and hardwood) and to evaluate their pro-inflammatory effects in THP-1 and A549 cells. Both cell lines responded to UFP producing interleukin-8 (IL-8), with wood log UFP being more active compared to pellet UFP. With the exception of higher effect observed with beech wood log UFP in THP-1, the ability of soft or hard woods to induce IL-8 release was similar. In addition, on weight mass, IL-8 release was similar or lower compared to diesel exhaust particles (DEP), arguing against higher biological activity of smaller size particles...
January 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/27984207/acquired-exchange-protein-directly-activated-by-cyclic-adenosine-monophosphate-activity-induced-by-p38-mitogen-activated-protein-kinase-in-primary-afferent-neurons-contributes-to-sustaining-postincisional-nociception
#19
Megumi Matsuda, Kentaro Oh-Hashi, Isao Yokota, Teiji Sawa, Fumimasa Amaya
BACKGROUND: The molecular mechanisms responsible for sustained pain after tissue injury are largely unknown. The aim of this study was to clarify the role of exchange protein directly activated by cyclic adenosine monophosphate (EPAC) in sustained postincisional nociception, using tissue injury-induced nociceptor priming, and involvement of p38 mitogen-activated protein kinase (p38MAPK) in EPAC-mediated nociceptor priming. METHODS: Plantar incisions were made in the hind paws of Sprague-Dawley rats (n = 144)...
January 2017: Anesthesiology
https://www.readbyqxmd.com/read/27981472/neuroprotective-effects-of-echinacoside-on-regulating-the-stress-active-p38mapk-and-nf-%C3%AE%C2%BAb-p52-signals-in-the-mice-model-of-parkinson-s-disease
#20
Jingsi Zhang, Zhennian Zhang, Jun Xiang, Min Cai, Zhonghai Yu, Xiangting Li, Ting Wu, Dingfang Cai
Herbal medicines have long been used to treat Parkinson's disease (PD). To systematically analyze the anti-parkinsonian activity of echinacoside (ECH) in a neurotoxic model of PD and provide a future basis for basic and clinical investigations, male C57BL/6 mice were randomized into blank control, PD model and ECH-administration groups. ECH significantly suppressed the dopaminergic neuron loss (P < 0.01) caused by MPTP and maintained dopamine content (P < 0.01) and dopamine metabolite content (P < 0...
December 15, 2016: Neurochemical Research
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