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p38MAPK

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https://www.readbyqxmd.com/read/29145851/ala-la-ameliorates-glucose-toxicity-on-hk-2-cells-by-attenuating-oxidative-stress-and-apoptosis-through-the-ros-p38-tgf-%C3%AE-1-pathway
#1
Mingxia Jiang, Haifen Zhang, Lijie Zhai, Bianliang Ye, Yin Cheng, Chengkai Zhai
BACKGROUND: Growing evidence indicates that oxidative stress (OS) plays a pivotal role in Diabetic nephropathy (DN). In a previous study we demonstrated that ALA/LA protected HK-2 cells against high glucose-induced cytotoxicity. So we aimed to establish the glucose injury model of HK-2 cells and investigate the beneficial effects of ALA/LA on high glucose-induced excessive production of TGF-β1 and the possible mechanisms mediating the effects. METHODS: The expression of OS markers in high glucose-induced HK-2 cells treated with ALA/LA...
November 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29123208/differential-t-cell-signaling-pathway-activation-by-tacrolimus-and-belatacept-after-kidney-transplantation-post-hoc-analysis-of-a-randomised-controlled-trial
#2
Nynke M Kannegieter, Dennis A Hesselink, Marjolein Dieterich, Gretchen N de Graav, Rens Kraaijeveld, Carla C Baan
Pharmacokinetic immunosuppressive drug monitoring poorly correlates with clinical outcomes after solid organ transplantation. A promising method for pharmacodynamic monitoring of tacrolimus (TAC) in T cell subsets of transplant recipients might be the measurement of (phosphorylated) p38MAPK, ERK1/2 and Akt (activated downstream of the T cell receptor) by phospho-specific flow cytometry. Here, blood samples from n = 40 kidney transplant recipients (treated with either TAC-based or belatacept (BELA)-based immunosuppressive drug therapy) were monitored before and throughout the first year after transplantation...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121798/angelica-sinensis-exerts-angiogenic-and-anti-apoptotic-effects-against-cerebral-ischemia-reperfusion-injury-by-activating-p38mapk-hif-1-formula-see-text-vegf-a-signaling-in-rats
#3
Chin-Yi Cheng, Tin-Yun Ho, Chien-Yun Hsiang, Nou-Ying Tang, Ching-Liang Hsieh, Shung-Te Kao, Yu-Chen Lee
This study evaluated the effects of Angelica sinensis extract [Dang Gui (DG)] administered before 60[Formula: see text]min of middle cerebral artery occlusion followed by 3[Formula: see text]d of reperfusion and investigated the involvement of mitogen-activated protein kinase (MAPK)/hypoxia-inducible factor (HIF)-1[Formula: see text] signaling in the cortical ischemic penumbra. DG was intraperitoneally administered at a dose of 0.25[Formula: see text]g/kg (DG-0.25g), 0.5[Formula: see text]g/kg (DG-0.5g), or 1[Formula: see text]g/kg (DG-1g) 30[Formula: see text]min before the onset of cerebral ischemia...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29118901/impacts-of-berberine-on-oxidized-ldl-induced-proliferation-of-human-umbilical-vein-endothelial-cells
#4
Rui-Xia Xu, Xian-Chang Sun, Chun-Yan Ma, Yu-Hong Yao, Xiao-Lin Li, Yuan-Lin Guo, Yan Zhang, Sha Li, Jian-Jun Li
Berberine (BBR), a Chinese medicine extracted from natural plant, has been demonstrated to improve lipid disorders. Oxidized low-density lipoprotein (oxLDL), a proatherogenic lipoprotein, has been shown to be involved in vascular endothelial cell dysfunction such as excessive or abnormal proliferation. The purpose of the present study was to investigate the impacts of BBR on cell proliferations as well as potential involving signal pathways. HUVECs were stimulated with oxLDL and co-cultured with BBR at a variety of concentrations in different time points...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29115173/role-of-gabab-receptors-and-p38mapk-nf-%C3%AE%C2%BAb-pathway-in-paclitaxel-induced-apoptosis-of-hippocampal-neurons
#5
Zhao Li, Peng Liu, Hailin Zhang, Shuang Zhao, Zi Jin, Rui Li, Yuexian Guo, Xiuli Wang
CONTEXT: The effects of the anticancer drug paclitaxel on learning and memory are rarely studied. OBJECTIVE: This study investigated changes in GABAB receptor expression during paclitaxel-induced apoptosis of hippocampal neurons and the role of the p38MAPK/NF-κB pathway in this process. MATERIALS AND METHODS: Hippocampal neurons isolated from neonatal Sprague-Dawley rats were divided into six groups: Control (C), SB (10 µL of 10-µmol/L SB203580), SN (53 µg/mL SN50), N (1 µmol/L paclitaxel), SB + N (10 µmol/L SB203580 + 1 µmol/L paclitaxel) and SN + N (53 µg/mL SN50 + 1 µmol/L paclitaxel)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29111086/role-of-interleukin-17-in-tgf-%C3%AE-signaling-mediated-renal-interstitial-fibrosis
#6
Bin Sun, Hui Wang, Lu Zhang, Xiaofan Yang, Mingshun Zhang, Xingxing Zhu, Xiaohui Ji, Huijuan Wang
BACKGROUND: Several studies suggest IL-17 is involved in the pathogenesis of organ fibrosis. The exact role of IL-17 in renal interstitial fibrosis has not been fully elucidated. METHODS: We compared the histopathology of renal fibrosis as well as profibrotic TGF-β signaling in wild-type (WT) and IL-17 knock-out (IL-17(-/-)) mice using UUO as the disease model. To find out the possible mechanisms involved in the exacerbated renal fibrosis happened to IL-17(-/-) mice, we analyzed the pattern of ECM synthesis by different fibroblasts cultured with IL-17 and associated signaling mediators...
October 27, 2017: Cytokine
https://www.readbyqxmd.com/read/29107962/apoptosis-signal-regulating-kinase-1-inhibition-attenuates-cardiac-hypertrophy-and-cardiorenal-fibrosis-induced-by-uremic-toxins-implications-for-cardiorenal-syndrome
#7
Feby Savira, Longxing Cao, Ian Wang, Wendi Yang, Kevin Huang, Yue Hua, Beat M Jucker, Robert N Willette, Li Huang, Henry Krum, Zhiliang Li, Qiang Fu, Bing Hui Wang
Intracellular accumulation of protein-bound uremic toxins in the setting of cardiorenal syndrome leads to adverse effects on cardiorenal cellular functions, where cardiac hypertrophy and cardiorenal fibrosis are the hallmarks. In this study, we sought to determine if Apoptosis Signal-Regulated Kinase 1 (ASK1), an upstream regulator of cellular stress response, mediates cardiac hypertrophy and cardiorenal fibrosis induced by indoxyl sulfate (IS) and p-cresol sulfate (PCS) in vitro, and whether ASK1 inhibition is beneficial to ameliorate these cellular effects...
2017: PloS One
https://www.readbyqxmd.com/read/29107213/current-and-future-treatment-options-for-pemphigus-is-it-time-to-move-towards-more-effective-treatments
#8
REVIEW
Soheil Tavakolpour
Systemic administration of corticosteroid (CS) remains the standard gold treatment for pemphigus. However, because of several long-term adverse effects, steroid-sparing agents are usually prescribed in combination with CSs. Despite the high number of available studies, the choice of best drugs to treat pemphigus remains controversial. Therapeutic approaches for pemphigus can be divided into traditional treatment and emerging ones. Personalized medicine, which aims to increase the efficacy as well as reduce adverse effects of treatments, could be considered as the future option...
December 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29099815/expression-of-heat-shock-protein-27-hsp27-and-p38mapk-in-esophageal-squamous-cell-carcinoma
#9
Yan Zhang, Zhiyin Feng, Weina Wang, Juanjuan Dong, Xiaojin Gong, Hongwei Pu, Xiao Chen
BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a worldwide concern. This study looked at the relationship between the expression of differential proteins and the clinicopathological data and survival rate of ESCC patients to identify potential tumor markers for the growth and metastasis of ESCC. MATERIAL AND METHODS This study included 162 patients who underwent surgical excision for management of ESCC. Fresh ESCC tissue and adjacent normal tissue specimens were collected. Protein expressions were detected by western blotting...
November 3, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29089075/-pyruvate-attenuates-the-injury-of-pc12-cells-induced-by-hypoxia-via-inhibiting-p38mapk-phosphorylation
#10
Min Wei, Kun Zhang, Zhijun Li, Ping Yang, Jianxiang Zhang, Huilin Liu
Objective To observe the protective effect of pyruvate against hypoxia-induced neuron injury and its mechanism. Methods PC12 cells were treated with pyruvate, and then exposed to 10 mL/L O2 for 12, 24 and 48 hours. The proliferation of PC12 cells was detected by MTT assay. The cell apoptosis was observed via the detection of caspase-3 activity. The levels of interleukin-1β (IL-1β), IL-6 and tumor necrosis factor α (TNF-α) were detected by ELISA. The expressions of p38MAPK and phosphorylated p38MAPK (p-p38MAPK) protein were tested by Western blotting...
September 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29071797/novel-genetic-variants-in-the-p38mapk-pathway-gene-zak-and-susceptibility-to-lung-cancer
#11
Yun Feng, Yanru Wang, Hongliang Liu, Zhensheng Liu, Coleman Mills, Kouros Owzar, Jichun Xie, Younghun Han, David C Qian, Rayjean J Hung Rj, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeböller, Albert Rosenberger, Richard S Houlston, Neil Caporaso, Maria Teresa Landi, Irene Brüske, Angela Risch, Yuanqing Ye, Xifeng Wu, David C Christiani, Christopher I Amos, Qingyi Wei
The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with lung cancer risk. To substantiate this finding, we used six genome-wide association studies (GWASs) to comprehensively investigate the associations of 14,904 single nucleotide polymorphisms (SNPs) in 108 genes of this pathway with lung cancer risk. We identified six significant lung cancer risk-associated SNPs in two genes (CSNK2B and ZAK) after correction for multiple comparisons by a false discovery rate (FDR) < 0...
October 26, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29058282/roles-of-tgf-%C3%AE-signaling-pathway-in-endoplasmic-reticulum-stress-in-endothelial-cells-stimulated-with-cigarette-smoke-extract
#12
Hong Huang, Qiu-Li Ding, Hui-Fen Zhu, Dao-Feng Yang
To investigate the role of signaling pathway in the effect of endoplasmic reticulum stress (ER stress) in endothelial cells stimulated with cigarette smoke extract (CSE). Human umbilical vein endothelial cells (HUVECs) were cultured and divided into 3 groups: CSE-stimulated group, CSE-stimulated with 4-PBA group, and negative control group. HUVECs were cultured and stimulated with CSE at concentrations of 5%, 10% and 20%, respectively, mRNA of CXCL-8 and GRP78 was detected by real-time PCR. ELISA was performed to test the expression of CXCL-8 protein, and neutrophils migration was detected by Transwell board test...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29051621/vector-independent-transmembrane-transport-of-oligodeoxyribonucleotides-involves-p38-mitogen-activated-protein-kinase-phosphorylation
#13
Minyuan Peng, Yanming Li, Jian Zhang, Yong Wu, Xiaoyang Yang, Ye Lei, Mao Ye, Jing Liu, Xu Han, Yijin Kuang, Xielan Zhao, Fangping Chen
The main roles of equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs) are to transfer single nucleosides and analogues for the nucleic acid salvage pathway. Oligodeoxyribonucleotides (ODNs) can be transported into the cytoplasm or nucleus of cells under certain conditions. Among ODNs composed of a single type of nucleotide, the transport efficiency differs with the length and nucleotide composition of the ODNs and varies in different types of leukaemia cells; among the 5 tested random sequence ODNs and 3 aptamers with varying sequences, the data showed that some sequences were associated with significantly higher transport efficiency than others...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29039784/crosstalk-influence-between-p38mapk-and-autophagy-on-mitochondria-mediated-apoptosis-induced-by-anti-fas-antibody-actinomycin-d-in-human-hepatoma-bel-7402-cells
#14
Yu Wang, Chunhui Xia, Yanxin Lv, Chengjun Li, Qingbu Mei, Hongmei Li, Haijun Wang, Shuang Li
Our previous study indicated that anti-Fas antibody/actinomycin D (AF/AD) induced apoptosis of human hepatocellular carcinoma Bel-7402 cells; however, crosstalk influence between P38MAPK and autophagy on mitochondria-mediated apoptosis induced by AF/AD in Bel-7402 cells remains unclear. Therefore, effect of AF/AD on apoptosis, autophagy, phosphorylated-P38MAPK (p-P38MAPK), and membrane potential (ΔΨm) with or without the P38MAPK inhibitor SB203580 or the autophagy inhibitor 3-methyladenine (3-MA) in Bel-7402 cells was investigated in the present study...
October 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29039338/anti-inflammatory-and-antiviral-effects-of-water-soluble-crude-extract-from-phragmites-australis-in-vitro
#15
Liqian Zhu, Dong Zhang, Chen Yuan, Xiuyan Ding, Yu Shang, Yuting Jiang, Guoqiang Zhu
Phragmitesaustralis (P. australis), a worldwide distributed wetland grass, is traditionally used as food-making helper and spice in China. The pharmacological effect of this plant is poorly understood. Here, we demonstrated that lipopolysaccharide (LPS)-induced production of inflammatory mediators nitric oxide (NO) and reactive oxygen species (ROS), and the pro-inflammatory cytokines tumor necrosis factor-a (TNF-a) and interleukin-1β (IL-1β) in RAW264.7 macrophage were significantly inhibited by the crude extract...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29038355/isolated-heart-model-demonstrates-evidence-of-contractile-and-diastolic-dysfunction-in-right-ventricles-from-rats-with-sugen-hypoxia-induced-pulmonary-hypertension
#16
Evandro M Neto-Neves, Andrea L Frump, Alexandra Vayl, Jeffrey A Kline, Tim Lahm
Although extensively used for the study of left ventricular function, limited experience exists with the isolated heart model in the evaluation of right ventricular (RV) function. In particular, no published experience exists with this tool in sugen/hypoxia-induced pulmonary hypertension (SuHx-PH), a frequently used model of severe and progressive PH We sought to characterize markers of RV contractile and diastolic function in SuHx-PH and to establish their relationship with markers of maladaptive RV remodeling...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29027919/shiga-toxins-induce-apoptosis-and-er-stress-in-human-retinal-pigment-epithelial-cells
#17
Jun-Young Park, Yu-Jin Jeong, Sung-Kyun Park, Sung-Jin Yoon, Song Choi, Dae Gwin Jeong, Su Wol Chung, Byung Joo Lee, Jeong Hun Kim, Vernon L Tesh, Moo-Seung Lee, Young-Jun Park
Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are the most potent known virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially fatal systemic complications such as acute renal failure, blindness and neurological abnormalities. Although numerous studies have defined apoptotic responses to Shiga toxin type 1 (Stx1) or Shiga toxin type 2 (Stx2) in a variety of cell types, the potential significance of Stx-induced apoptosis of photoreceptor and pigmented cells of the eye following intoxication is unknown...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/29026158/ginsenoside-rb1-prevents-homocysteine-induced-epc-dysfunction-via-vegf-p38mapk-and-sdf-1-cxcr4-activation
#18
Tao-Hua Lan, Dan-Ping Xu, Man-Ting Huang, Ju-Xian Song, Huan-Lin Wu, Min Li
Hyperhomocystinemia (HHcy) is known as an independent risk factor for cardiovascular disease. Our previous study showed that ginsenoside Rb1, the major active constituent of ginseng, prevents homocysteine (Hcy)-induced endothelial damage. However, the role of ginsenoside Rb1 in Hcy-induced dysfunction in endothelial progenitor cells (EPCs) remains unknown. In the study, we found that ginsenoside Rb1 reversed the Hcy-induced impairment of adhesive and migratory ability in EPCs which were significantly abolished by CXCR4 antagonist AMD3100 and VEGFR2 inhibitor SU5416...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024968/iron-suppresses-ovarian-granulosa-cell-proliferation-and-arrests-cell-cycle-through-regulating-p38-mitogen-activated-protein-kinase-p53-p21-pathway
#19
Mei-Jou Chen, Chia-Hong Chou, Chia-Tung Shun, Tsui-Lien Mao, Wen-Fen Wen, Chin-Der Chen, Shee-Uan Chen, Yu-Shih Yang, Hong-Nerng Ho
Iron is an essential nutrient that may exert toxic effects when it accumulates in tissues. Little is known regarding its effects on gonadal function. Both Fe2+ and Fe3+ could be released from iron deposition. We employed mouse nonluteinized granulosa cell for in vitro studies and human ovarian tissues for Prussian blue and immunohistochemical staining to identify the iron deposition and effect in vivo. After treatment with FeSO4-7H2O or FeCl3 in granulosa cell cultured with follicle-stimulating hormone (FSH) for 48 h, we found that Fe2+ significantly suppressed FSH-induced granulosa cell proliferation and arrested the cell cycle at the G2/M phase by cell proliferation assay and flow cytometry...
September 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29023945/microrna-29a-inhibits-proliferation-and-motility-of-schwannoma-cells-by-targeting-cdk6
#20
Ji Ma, Tengfei Li, Huifeng Yuan, Xinwei Han, Shaofeng Shui, Dong Guo, Lei Yan
AIM: MicroRNA-29 (miR-29)family involved in various types of cancer regulation. Although miR-29a was shown to play an inhibitory role in tumorigenesis, the effect of miR-29a expression on schwannoma cells still remains unclear. In this study, we aimed to explore the role of miR-29a in schwannoma. METHODS: The expressions of miR-29a, miR-29b and miR-29c were detected in the Schwann tissues and cell lines using qRT-PCR. The effect of miR-29a, miR-29b and miR-29c on cell viability, migration, invasion and apoptosis was tested...
October 11, 2017: Journal of Cellular Biochemistry
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