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https://www.readbyqxmd.com/read/29791572/is-lipid-accumulation-product-associated-with-an-atherogenic-lipoprotein-profile-in-brazilian-subjects
#1
Flavia De Conti Cartolano, Caroline Pappiani, Maria Camila Prupper de Freitas, Antonio M Figueiredo Neto, Antônio Augusto Ferreira Carioca, Nágila Raquel Teixeira Damasceno
BACKGROUND: Lipid accumulation product (LAP), a simple and low-cost tool, is a novel biomarker of central lipid accumulation and represents a potential surrogate marker for atherogenic lipoprotein profile. However, its association with lipoprotein subfractions has not been described in the literature. OBJECTIVE: To determine whether LAP index could be used as a marker of low- and high-density lipoprotein (LDL and HDL) size in Brazilian individuals. METHODS: This cross-sectional study included patients (n = 351) of both sexes and age between 30-74 years...
April 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29789580/the-effects-of-anti-lap-monoclonal-antibody-down-regulation-of-cd4-lap-t-cells-on-allogeneic-corneal-transplantation-in-mice
#2
Shang Li, Hongshuang Lu, Ruti Sella, Wei Zhang, Hongwei Dong, Chungang Guo, Natalie A Afshari, Zhiqiang Pan, Ying Jie
CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to a decrease in the percentage of T cells expressing CD4+Foxp3+, CD4+GARP+, CD4+LAP+ and CD4+IL-10+ in the lymph nodes and spleens of mice undergoing orthotopic penetrating transplantation of corneal allograft, without affecting corneal graft survival...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29788408/effects-of-4-hydroxy-2-3-3-4-5-pentachlorobiphenyl-4-oh-cb107-on-liver-transcriptome-in-rats-implication-in-the-disruption-of-circadian-rhythm-and-fatty-acid-metabolism
#3
Mari Ochiai, Midori Iida, Tetsuro Agusa, Kohki Takaguchi, Satoshi Fujiic, Kei Nomiyama, Hisato Iwata
Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) have been detected in tissues of both wild animals and humans. Several previous studies have suggested adverse effects of OH-PCBs on the endocrine and nervous systems in mammals. However, there have been no studies on transcriptome analysis of the effects of OH-PCBs, and thus, the whole picture and mechanisms underlying the adverse effects induced by OH-PCBs are still poorly understood. We therefore investigated the mRNA expression profile in the liver of adult male Wistar rats treated with 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) to explore the genes responsive to OH-PCBs and to understand the potential effects of the chemical...
May 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29784888/identification-of-brain-metastasis-genes-and-therapeutic-evaluation-of-histone-deacetylase-inhibitors-in-a-clinically-relevant-model-of-breast-cancer-brain-metastasis
#4
Soo-Hyun Kim, Richard P Redvers, Lap Hing Chi, Xiawei Ling, Andrew J Lucke, Robert C Reid, David P Fairlie, Ana Carolina Baptista Moreno Martin, Robin L Anderson, Delphine Denoyer, Normand Pouliot
Breast cancer brain metastasis remains largely incurable. While several mouse models have been developed to investigate the genes and mechanisms regulating breast cancer brain metastasis, these models often lack clinical relevance since they require the use of immune-compromised mice and/or are poorly metastatic to brain from the mammary gland. We describe the development and characterisation of an aggressive brain metastatic variant of the 4T1 syngeneic model (4T1Br4) that spontaneously metastasises to multiple organs, but is selectively more metastatic to the brain from the mammary gland than parental 4T1 tumours...
May 21, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29783745/loading-of-indocyanine-green-within-polydopamine-coated-laponite-nanodisks-for-targeted-cancer-photothermal-and-photodynamic-therapy
#5
Fanli Xu, Mengxue Liu, Xin Li, Zhijuan Xiong, Xueyan Cao, Xiangyang Shi, Rui Guo
The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) in cancer treatment has attracted much attention in recent years. However, developing highly efficient and targeted therapeutic nanoagents for amplifying PTT and PDT treatments remains challenging. In this work, we developed a novel photothermal and photodynamic therapeutic nanoplatform for treatment of cancer cells overexpressing integrin αv β₃ through the coating of polydopamine (PDA) on indocyanine green (ICG)-loaded laponite (LAP) and then further conjugating polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) as targeted agents on the surface...
May 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29783633/butyrylation-of-maize-and-potato-starches-and-characterization-of-the-products-by-nuclear-magnetic-resonance-and-in-vitro-fermentation
#6
Tina Skau Nielsen, Nuria Canibe, Flemming Hofmann Larsen
Intake of butyrylated starches may increase colonic butyrate supply, which can be of public health and clinical benefit by maintaining colonic health. The objective was to investigate if an organocatalytic method with tartaric acid as a catalyst could be applied to produce butyrylated products from different starch sources and to characterize their chemical structure and fermentation capability by using solid-state 13 C MAS NMR (magic angle spinning nuclear magnetic resonance) spectroscopy and an in vitro fermentation model, respectively...
May 18, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29770928/body-adiposity-index-lipid-accumulation-product-and-cardiometabolic-index-reveal-the-contribution-of-adiposity-phenotypes-in-the-risk-of-hyperuricemia-among-chinese-rural-population
#7
Haoyu Wang, Yingxian Sun, Shuze Wang, Hao Qian, Pengyu Jia, Yintao Chen, Zhao Li, Lijun Zhang
Adiposity phenotypes, estimated by higher body adiposity index (BAI), lipid accumulation product (LAP), and cardiometabolic index (CMI), has conferred increased metabolic risk. The relative contribution of BAI, LAP, and CMI in hyperuricemia, however, is unknown. We hypothesized that these obesity indicators would refine identification of hyperuricemia. Information on serum uric acid (SUA), fasting lipid profiles, and body adiposity measures (BAI, LAP, and CMI) were recorded in a cross-sectional population-based sample of 11,102 participants (≥ 35 years old) from China...
May 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29770584/pure-laparoscopic-right-hemihepatectomy-using-the-caudodorsal-side-approach-with-videos
#8
Koki Maeda, Goro Honda, Masanao Kurata, Yuki Homma, Manami Doi, Jun Yamamoto, Yusuke Ome
BACKGROUND: In our process of standardizing laparoscopic right hemihepatectomy (Lap-RH), we found several advantages of the laparoscopic caudate lobe first approach by utilizing a unique laparoscopic caudodorsal view. METHODS: Between April 2012 and October 2017, 21 patients underwent pure Lap-RH at our hospital. The mean patient age was 62 years (range, 36-75 years), and there were more male than female patients (66.7%). Of 21 patients, 11 had hepatocellular carcinoma, 8 had metastatic tumor, and the other 2 had focal nodular hyperplasia and refractory liver abscess...
May 17, 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29768534/impact-of-dexmedetomidine-on-hemodynamics-in-rabbits
#9
Jianjun Ren, Changfa Li, Shuxian Ma, Jiangli Wu, Yanjie Yang
PURPOSE: To evaluate the effects of single intravenous administration of Dexmedetomidine (DEX) on hemodynamics in rabbits. METHODS: A total of 32 New Zealand white rabbits were randomly divided into the control group (Group C), Group D1 (2.75 μg/kg), Group D2 (5.5 μg/kg), and Group D3 (8.25 μg/kg) to compare systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), central venous pressure (CVP), left ventricular systolic pressure (LVSP), left ventricular end-stage diastolic pressure (LVEDP), left ventricular developmental pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax at different time points...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29766641/tailoring-the-homing-capacity-of-human-tregs-for-directed-migration-to-sites-of-th1-inflammation-or-intestinal-regions
#10
Romy E Hoeppli, Katherine N MacDonald, Pascal Leclair, Vivian C W Fung, Majid Mojibian, Jana Gillies, Seyed M R Rahavi, Andrew I M Campbell, Sanjiv K Gandhi, Anne M Pesenacker, Gregor Reid, Chinten J Lim, Megan K Levings
Cell-based therapy with CD4+ FOXP3+ Regulatory T cells (Tregs) is a promising strategy to limit organ rejection and graft-versus-host disease. Ongoing clinical applications have yet to consider how human Tregs could be modified to direct their migration to specific inflammation sites and/or tissues for more targeted immunosuppression. We show here that stable, homing-receptor-tailored human Tregs can be generated from thymic Tregs isolated from pediatric thymus or adult blood. To direct migration to Th1-inflammatory sites, addition of IFN-γ and IL-12 during Treg expansion produced suppressive, epigenetically-stable CXCR3+ TBET+ FOXP3+ Th1-Tregs...
May 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29763461/night-shift-work-exposure-profile-and-obesity-baseline-results-from-a-chinese-night-shift-worker-cohort
#11
Miaomiao Sun, Wenting Feng, Feng Wang, Liuzhuo Zhang, Zijun Wu, Zhimin Li, Bo Zhang, Yonghua He, Shaohua Xie, Mengjie Li, Joan P C Fok, Gary Tse, Martin C S Wong, Jin-Ling Tang, Samuel Y S Wong, Jelle Vlaanderen, Greg Evans, Roel Vermeulen, Lap Ah Tse
AIMS: This study aimed to evaluate the associations between types of night shift work and different indices of obesity using the baseline information from a prospective cohort study of night shift workers in China. METHODS: A total of 3,871 workers from five companies were recruited from the baseline survey. A structured self-administered questionnaire was employed to collect the participants' demographic information, lifetime working history, and lifestyle habits...
2018: PloS One
https://www.readbyqxmd.com/read/29762680/tuberculosis-and-the-art-of-macrophage-manipulation
#12
S Upadhyay, E Mittal, J A Philips
Macrophages are first-line responders against microbes. The success of Mycobacterium tuberculosis (Mtb) rests upon its ability to convert these antimicrobial cells into a permissive cellular niche. This is a remarkable accomplishment, as the antimicrobial arsenal of macrophages is extensive. Normally bacteria are delivered to an acidic, degradative lysosome through one of several trafficking pathways, including LC3-associated phagocytosis (LAP) and autophagy. Once phagocytozed, the bacilli are subjected to reactive oxygen and nitrogen species, and they induce the expression of proinflammatory cytokines, which serve to augment host responses...
June 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29757743/local-all-pass-geometric-deformations
#13
Christopher Gilliam, Thierry Blu
This paper deals with the estimation of a deformation that describes the geometric transformation between two images. To solve this problem, we propose a novel framework that relies upon the brightness consistency hypothesis-a pixel's intensity is maintained throughout the transformation. Instead of assuming small distortion and linearizing the problem (e.g. via Taylor Series expansion), we propose to interpret the brightness hypothesis as an all-pass filtering relation between the two images. The key advantages of this new interpretation are that no restrictions are placed on the amplitude of the deformation or on the spatial variations of the images...
February 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29754169/short-and-long-term-outcomes-after-colorectal-anastomotic-leakage-is-affected-by-surgical-approach-at-reoperation
#14
Jens Ravn Eriksen, Henrik Ovesen, Ismail Gögenur
BACKGROUND: Anastomotic leakage is the most serious surgical complication following colorectal resection, and surgical intervention is often required. The purpose of the study was to investigate short- and long-term outcomes after reoperation for anastomotic leakage. METHOD: Patients with a symptomatic anastomotic leakage following a laparoscopic colorectal cancer resection from January 2009 to December 2014 were identified from our local prospective database. Patients were grouped according to the management of anastomotic leaks: local, lap, or open approach...
May 12, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29747325/-association-between-the-ratio-of-early-diastolic-transmitral-velocity-to-early-diastolic-mitral-annular-velocity-and-invasive-measured-left-atrial-pressure-in-patients-with-atrial-fibrillation-and-preserved-left-ventricular-ejection-fraction
#15
G G Ma, L G Fang, P Gao, Z W Cheng, T B Chen, X Lin, K A Cheng, H Deng, Q Fang
Objective: To evaluate the association between the ratio of early diastolic transmitral velocity to early diastolic mitral annular velocity (E/E') and left atrial pressure (LAP) estimated from invasive catheter measurements in patients with atrial fibrillation (AF). Methods: A total of 46 consecutive patients with non-valvular AF and preserved left ventricular ejection fraction (LVEF) admitted in our department to receive the first radiofrequency ablation from May to July 2017 were included. All patients underwent echocardiography at 24-48 hours before radiofrequency ablation, and LAP was invasively measured during the ablation procedure...
April 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29747212/association-between-insulin-resistance-and-cardiovascular-risk-factors-in-polycystic-ovary-syndrome-patients
#16
Miriam da Silva Wanderley, Lara Cristina Ribeiro Pereira, Carla Borges Santos, Vinícius Santos da Cunha, Mariam Viviane Jovino Neves
OBJECTIVE:  To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. METHODS:  Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29745743/elite-male-and-female-800-m-runners-display-different-pacing-strategies-during-seasons-best-performances
#17
Filipas Luca, Nerli Ballati Emiliano, Bonato Matteo, La Torre Antonio, Piacentini Maria Francesca
PURPOSE: To analyse the pacing profiles of the world top 800-m annual performances between 2010 and 2016, comparing male and female strategies. METHODS: One hundred and forty two performances were characterised for overall race times and 0-200 m, 200-400 m, 400-600 m, 600-800 m split times using available footage from YouTube. Only the best annual performance for each athlete was considered. Overall race and splits speed were calculated so that each lap speed could be expressed as a percentage of the mean race speed...
May 10, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29742682/lipid-accumulation-product-and-visceral-adiposity-index-are-associated-with-dietary-patterns-in-adult-americans
#18
Mohsen Mazidi, Hong-Kai Gao, Andre Pascal Kengne
In the present study, we aimed to examine the association between lipid accumulation product (LAP) and visceral adiposity index (VAI) with dietary pattern (DP) in the US adults. Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on dietary intake from 2005 to 2010 were included. DPs were derived by principal component analysis. We applied analysis of covariance and multivariable-adjusted linear regressions accounting for the masked variance and utilizing the proposed weighting methodology...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29742342/receptor-based-peptides-for-inhibition-of-rtx-leukotoxin-ltxa-activity
#19
Eric Krueger, Shannon Hayes, En Hyung Chang, Shailagne Yutuc, Angela C Brown
The Gram-negative bacterium Aggregatibacter actinomycetemcomitans, commonly associated with localized aggressive periodontitis (LAP), secretes an RTX (repeats-in-toxin) protein leukotoxin (LtxA) that targets human white blood cells, an interaction that is driven by its recognition of the lymphocyte function-associated antigen-1 (LFA-1) integrin. In this study, we report on the inhibition of LtxA-LFA-1 binding as an anti-virulence strategy to inhibit LtxA-mediated cytotoxicity. Specifically, we designed and synthesized peptides corresponding to the reported LtxA binding domain on LFA-1 and characterized their capability to inhibit LtxA binding to LFA-1 and subsequent cytotoxic activity in human immune cells...
May 9, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29741441/effect-of-an-active-video-gaming-classroom-curriculum-on-health-related-fitness-school-day-step-counts-and-motivation-in-sixth-graders
#20
You Fu, Ryan D Burns
BACKGROUND: The purpose of this study was to explore the effect of an active video gaming (AVG) classroom curriculum on health-related fitness, school day steps, and motivation in sixth graders. METHODS: A convenience sample of 65 sixth graders were recruited from 2 classrooms from a school located in the Western United States. One classroom served as the comparison group (n = 32) that participated in active free play, and one classroom served as the intervention group (n = 33) that participated in an AVG curriculum for 30 minutes per day, 3 days per week, for 18 weeks...
May 9, 2018: Journal of Physical Activity & Health
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