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https://www.readbyqxmd.com/read/29144802/lipid-accumulation-product-visceral-adiposity-index-and-chinese-visceral-adiposity-index-as-markers-of-cardiometabolic-risk-in-adult-growth-hormone-deficiency-patients-a-cross-sectional-study
#1
Xin Xie, Qing Li, Lingmin Zhang, Wei Ren
OBJECTIVE: Adult growth hormone deficiency (AGHD) is associated with cardiometabolic risk factors. Given that cardiovascular disease (CVD) is an important cause of morbidity and mortality in the AGHD population, there is a need for alternative, non-invasive methods of assessing cardiometabolic risk in this population. Chinese visceral adiposity index (CVAI) is a new marker of visceral fat dysfunction that is based on age, body mass index (BMI), waist circumference (WC) and metabolic parameters...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142012/a-transcatheter-interatrial-shunt-device-for-the-treatment-of-heart-failure-with-preserved-ejection-fraction-reduce-lap-hf-i-a-phase-2-randomized-sham-controlled-trial
#2
Ted Feldman, Laura Mauri, Rami Kahwash, Sheldon Litwin, Mark J Ricciardi, Pim van der Harst, Martin Penicka, Peter S Fail, David M Kaye, Mark C Petrie, Anupam Basuray, Scott L Hummel, Rhondalyn Forde-McLean, Christopher D Nielsen, Scott Lilly, Joseph M Massaro, Daniel Burkhoff, Sanjiv J Shah
Background -In non-randomized, open-label studies, a transcatheter interatrial shunt device (IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure (PCWP), less symptoms, and greater quality of life and exercise capacity in patients with heart failure (HF) and mid-range or preserved ejection fraction (EF ≥ 40%). We conducted the first randomized, sham-controlled trial to evaluate the IASD in HF with EF ≥ 40%. Methods -REDUCE LAP-HF I was a phase 2, randomized, parallel-group, blinded multicenter trial in patients with New York Heart Association (NYHA) class III or ambulatory class IV HF, EF ≥ 40%, exercise PCWP ≥ 25 mmHg, and PCWP-right atrial pressure gradient ≥ 5 mmHg...
November 15, 2017: Circulation
https://www.readbyqxmd.com/read/29137118/modeling-skin-injury-from-hot-spills-on-clothing
#3
Torgrim Log
The present work analyzes scald burns from hot beverages, such as coffee and tea, spilled on the lap, i.e., an incident that may occur in daily life. The Pennes bioheat equation is solved numerically for small spills wetting the clothing, i.e., the fabric prevents the spilled liquid from draining away. Temperatures are analyzed in the wetted fabric and the skin layers and the resulting skin injury is calculated based on the basal layer temperature. Parameters influencing burn severity, such as clothing thickness, liquid temperature, removal of fabric and thermal effects of post scald water cooling are analyzed...
November 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29136482/impact-of-an-elementary-school-based-intervention-on-physical-activity-time-and-aerobic-capacity-georgia-2013-2014
#4
Hayley A Braun, Christi M Kay, Patricia Cheung, Paul S Weiss, Julie A Gazmararian
OBJECTIVES: The objectives of this study were to (1) determine the impact of a 1-year elementary school physical activity intervention on changes in teacher-reported school-based physical activity time and (2) assess the relationship between these changes and changes in student aerobic capacity. METHODS: HealthMPowers, a nonprofit organization, provided a multicomponent physical activity intervention to 3479 students in 39 schools in Georgia during 2013-2014. HealthMPowers administered a survey to faculty members before (August 2013) and after (May 2014) the intervention to measure student physical activity times...
November 2017: Public Health Reports
https://www.readbyqxmd.com/read/29134671/macrophage-roles-in-the-clearance-of-apoptotic-cells-and-control-of-inflammation-in-the-prostate-gland-after-castration
#5
Juliete A F Silva, Alexandre Bruni-Cardoso, Taize M Augusto, Danilo M Damas-Souza, Guilherme O Barbosa, Sérgio L Felisbino, Dagmar R Stach-Machado, Hernandes F Carvalho
BACKGROUND: Androgen deprivation results in massive apoptosis in the prostate gland. Macrophages are actively engaged in phagocytosing epithelial cell corpses. However, it is unknown whether microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis (LAP) is involved and contribute to prevent inflammation. METHODS: Flow cytometry, RT-PCR and immunohistochemistry were used to characterize the macrophage subpopulation residing in the epithelial layer of the rat ventral prostate (VP) after castration...
November 14, 2017: Prostate
https://www.readbyqxmd.com/read/29134264/oxygen-desaturation-in-daily-life-and-during-a-laboratory-based-protocol-of-activities-of-daily-living-in-copd-is-there-relationship
#6
Thaís Sant'Anna, Leila Donária, Nidia A Hernandes, Karina C Furlanetto, Décio S Barbosa, Rik Gosselink, Fabio Pitta
PURPOSE: To analyze the relationship between oxygen desaturation episodes during a laboratory-based ADL protocol and in real-life routine in patients with stable chronic obstructive pulmonary disease (COPD). METHODS: Twenty patients with stable COPD (12 men, 70 ± 7 years, FEV1% 54 ± 15 predicted) with no indication for long-term oxygen therapy (LTOT) were submitted to assessments including ADL performance by the Londrina ADL Protocol (LAP) and level of physical activity in daily life, both while submitted to simultaneous activity and pulse oximeter monitoring...
November 13, 2017: Lung
https://www.readbyqxmd.com/read/29132401/meta-analysis-comparing-laparoscopic-versus-open-resection-for-gastric-gastrointestinal-stromal-tumors-larger-than-5%C3%A2-cm
#7
Xiao Lian, Fan Feng, Man Guo, Lei Cai, Zhen Liu, Shushang Liu, Shuao Xiao, Gaozan Zheng, Guanghui Xu, Hongwei Zhang
BACKGROUND: Data on the safety and feasibility of laparoscopic versus open resection for gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm are limited. Therefore, the aim of this meta-analysis was to compared laparoscopic and open resection for gastric GISTs larger than 5 cm. METHODS: We perform a literature search on PubMed, the Cochrane Library, and Embase. Review Manage version 5.1 (RevMan 5.1) was used for data analysis. The GRADE profiler software (version 3...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29132336/study-protocol-the-labor-progression-study-laps-does-the-use-of-a-dynamic-progression-guideline-in-labor-reduce-the-rate-of-intrapartum-cesarean-sections-in-nulliparous-women-a-multicenter-cluster-randomized-trial-in-norway
#8
Stine Bernitz, Rebecka Dalbye, Pål Øian, Jun Zhang, Torbjørn Moe Eggebø, Ellen Blix
BACKGROUND: The increasing rate of intrapartum cesarean sections is subject of attention and concern as it is associated with adverse outcomes. Labor dystocia is one of the most frequent indications for cesarean sections even though there is no consensus on criteria for labor dystocia. Traditionally the progression of labor follows guidelines based on Friedman's curve from the mid 1950s. In 2010 Zhang presented a new labor curve and a dynamic guideline for labor progression based on contemporary research...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29132117/an-extrapulmonary-manifestation-of-lymphangioleiomyomatosis-a-rare-case-report
#9
L Volkan Tümay, Osman Serhat Güner, Abdullah Zorluoğlu
Lymphangioleiomyomatosis (LAM) is a rare and fatal disease which occurs almost exclusively in young women. The disease often affects lungs and most of the patients die from respiratory failure. It is often initially misdiagnosed as asthma or chronic obstructive pulmonary disease. The most common presentations of pulmonary LAM (P-LAM) include dyspnea and coughing. Chylothorax and spontaneous pneumothorax may be seen in advanced cases. Although rare, it may present with extrapulmonary LAM (E-LAM). Renal angiomyolipomas and abdominal lymphadenopathies (LAPs) are common in E-LAM cases...
November 9, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29125801/laparoscopic-versus-open-restorative-proctocolectomy-for-familial-adenomatous-polyposis
#10
Fábio Guilherme Campos, Carlos Augusto Real Martinez, Mariane Gouveia Monteiro de Camargo, Daniele Menezes Cesconetto, Sérgio Carlos Nahas, Ivan Cecconello
PURPOSE: This study compared outcomes after laparoscopic (LAP) or conventional (open) total proctocolectomy with outcomes after ileal J-pouch anal anastomosis (IPAA) at a single institution. METHODS: Charts from 133 familial adenomatous polyposis patients (1997-2013) were reviewed. Demographic data (age, sex, color, American Society of Anesthesiologists [ASA] status, previous surgery, and body mass index) and surgical outcomes (length of stay, early and late morbidity, reoperation, and mortality rates) were compared among 63 patients undergoing IPAA...
November 10, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29121090/differences-between-racing-and-non-racing-drivers-a-simulator-study-using-eye-tracking
#11
Peter M van Leeuwen, Stefan de Groot, Riender Happee, Joost C F de Winter
Motorsport has developed into a professional international competition. However, limited research is available on the perceptual and cognitive skills of racing drivers. By means of a racing simulator, we compared the driving performance of seven racing drivers with ten non-racing drivers. Participants were tasked to drive the fastest possible lap time. Additionally, both groups completed a choice reaction time task and a tracking task. Results from the simulator showed faster lap times, higher steering activity, and a more optimal racing line for the racing drivers than for the non-racing drivers...
2017: PloS One
https://www.readbyqxmd.com/read/29118762/lc3-associated-phagocytosis-is-required-for-dendritic-cell-inflammatory-cytokine-response-to-gut-commensal-yeast-saccharomyces-cerevisiae
#12
Dimitra Lamprinaki, Gemma Beasy, Aleksandra Zhekova, Alexandra Wittmann, Steve James, Jo Dicks, Yoichiro Iwakura, Shinobu Saijo, Xiaomin Wang, Chung-Wai Chow, Ian Roberts, Tamas Korcsmaros, Ulrike Mayer, Thomas Wileman, Norihito Kawasaki
The human fungal microbiota known as mycobiota is increasingly recognized as a critical factor in human gut health and disease. Non-pathogenic commensal yeasts such as Saccharomyces cerevisiae promote homeostasis in the gut, whereas dysbiosis of the gut mycobiota is associated with inflammation. Glycan-binding receptors (lectins) are key host factors in host-mycobiota interaction in the gut. They are expressed on immune cells such as dendritic cells (DCs) and recognize fungal polysaccharides. This interaction is imperative to mount appropriate immune responses for immune homeostasis in the gut as well as clearance of fungal pathogens...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29117870/is-there-enough-interest-in-and-pleasure-in-the-concept-of-depression-the-development-of-the-leuven-affect-and-pleasure-scale-laps
#13
Koen Demyttenaere, Philippe Mortier, Glenn Kiekens, Ronny Bruffaerts
OBJECTIVE: Presence of negative mood (depressed mood) and anhedonia (lack of interest and pleasure) are considered core symptoms of depression, while absence of positive mood is not taken into account. It is therefore remarkable that the depression scales routinely used to assess changes during antidepressant treatment (Hamilton Depression Rating Scale [HDRS], Montgomery-Åsberg Depression Rating Scale [MADRS]) do not really take into account anhedonia. Several scales were developed to assess positive mood and hedonic tone, but they only partially cover the multidimensional concept...
November 9, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29117508/oral-pathogenesis-of-aggregatibacter-actinomycetemcomitans
#14
REVIEW
Pourya Gholizadeh, Ali Pormohammad, Hosein Eslami, Behrooz Shokouhi, Vahid Fakhrzadeh, Hossein Samadi Kafil
Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a Gram-negative, facultative anaerobic bacillus that causes periodontal diseases such as localized aggressive periodontitis (LAP) and. consequently. bone resorption. The potential virulence factors of this organism are powerful leukotoxin, lipopolysaccharide (LPS), cell surface-associated materials, enzymes, and less well-defined virulence factors that will modulate the activity of the host defenses. This organism can induce bone resorption by various virulence factors in periodontal disease...
November 5, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29117228/the-pacing-strategy-and-technique-of-male-cross-country-skiers-with-different-levels-of-performance-during-a-15-km-classical-race
#15
Boye Welde, Thomas L Stöggl, Gunnar E Mathisen, Matej Supej, Chiara Zoppirolli, Andreas K Winther, Barbara Pellegrini, Hans-Christer Holmberg
In this study the pacing strategy, cycle characteristics and choice of technique of elite male cross-country (XC) skiers during a three-lap, 15-km classical race with interval start were measured. During the Norwegian Championships in 2016, fast (n = 18, age: 26±4 yr; height: 182±4 cm; body mass: 78±3 kg (means±SD)) and slow skiers (n = 18, age: 22±2 yr; height: 183±5 cm; body mass: 78±6 kg) were video recorded on flat (0°), intermediate (3.5°) and uphill sections (7.1°) of the first and final laps...
2017: PloS One
https://www.readbyqxmd.com/read/29115900/preparation-characterization-and-antitumor-activity-evaluation-of-apigenin-nanoparticles-by-the-liquid-antisolvent-precipitation-technique
#16
Weiwei Wu, Yuangang Zu, Li Wang, Lingling Wang, Huimei Wang, Yuanyuan Li, Mingfang Wu, Xiuhua Zhao, Yujie Fu
The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-Expert(®) software. Under the optimum conditions, the particle size of the apigenin nanosuspension was about 159.2 nm. In order to get apigenin nanoparticles, the freeze-drying method was selected and the mannitol was used as a cryoprotectant...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29106782/expression-and-assembly-of-largest-foreign-protein-in-chloroplasts-oral-delivery-of-human-fviii-made-in-lettuce-chloroplasts-robustly-suppresses-inhibitor-formation-in-hemophilia-a-mice
#17
Kwang-Chul Kwon, Alexandra Sherman, Wan-Jung Chang, Aditya Kamesh, Moanaro Biswas, Roland W Herzog, Henry Daniell
Inhibitor formation is a serious complication of factor VIII (FVIII) replacement therapy for the X-linked bleeding disorder hemophilia A and occurs in 20-30% of patients. No prophylactic tolerance protocol currently exists. Although we reported oral tolerance induction using FVIII domains expressed in tobacco chloroplasts, significant challenges in clinical advancement include expression of the full-length CTB-FVIII sequence to cover the entire patient population, regardless of individual CD4(+) T cell epitope responses...
November 6, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29105530/the-relationship-between-il-18-and-atherosclerotic-cardiovascular-risk-in-egyptian-lean-women-with-polycystic-ovary-syndrome
#18
Alaaeldin Dawood, Nabil Alkafrawy, Said Saleh, Rasha Noreldin, Shimaa Zewain
BACKGROUND: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The evidence in support of low-grade inflammation in PCOS as an etiology is emerging. Inflammation is likely to be associated with other prominent aspects of PCOS including insulin resistance (IR) and cardiovascular disease (CVD) risk. Interleukin-18 (IL-18) is considered as a strong marker of inflammation. OBJECTIVES: Evaluation of the relation between serum IL-18 and atherosclerotic CVD (ASCVD) risk in Egyptian lean females with PCO...
November 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29105327/hemodynamic-guidance-of-mitral-paravalvular-leak-closure-the-v-is-the-key
#19
EDITORIAL
James A Goldstein
Severe mitral paravalvular leak (PVL) induces elevated mean left atrial (LA) pressure (LAP) and prominent V waves, leading to pulmonary hypertension and right heart failure PVL closure promptly reduces V wave and mean LAP, correlates with improved echo regurgitation grade, and exerts immediate benefit to the lungs and right heart Hemodynamic response patterns facilitate PVL closure.
November 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29099624/pelvic-restraint-cushion-sled-test-evaluation-of-pelvic-forward-motion
#20
Greg Shaw, David Lessley, Joseph Ash, Salvador Acosta, Sara Heltzel, Patrick Riley, Taewung Kim, Jeff Crandall
OBJECTIVE: This study was designed to evaluate the performance of a pelvic restraint cushion (PRC), a submarining countermeasure that deploys under the thighs when a crash is detected in order to block the forward motion of the pelvis. METHODS: Sled tests approximating low and high speed frontal impacts were conducted with four PMHS female subjects restrained by a lap and shoulder belt in the right front passenger seat. The subjects were tested with and without a PRC...
November 3, 2017: Traffic Injury Prevention
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