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https://www.readbyqxmd.com/read/27911325/autonomic-nervous-system-dysfunctions-as-a-basis-for-a-predictive-model-of-risk-of%C3%A2-neurological-disorders-in-subjects-with%C3%A2-prior-history-of-traumatic-brain-injury-implications-in-alzheimer-s-disease
#1
Lap Ho, Marc Legere, Tongbin Li, Samara Levine, Ke Hao, Breanna Valcarcel, Giulio M Pasinetti
Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer's disease (AD) are also implicated in the central autonomic nervous system (ANS) regulation. For example, deficits in central cholinergic function in AD could likely lead to autonomic dysfunction. We recently developed a simple, readily applicable evaluation for monitoring ANS disturbances in response to traumatic brain injury (TBI)...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27908524/genetic-correlation-between-alcohol-preference-and-conditioned-fear-exploring-a-functional-relationship
#2
Julia A Chester, Marcus M Weera
Post-traumatic stress disorder (PTSD) and alcohol-use disorders have a high rate of co-occurrence, possibly because they are regulated by common genes. In support of this idea, mice selectively bred for high (HAP) alcohol preference show greater fear potentiated startle (FPS), a model for fear-related disorders such as PTSD, compared to mice selectively bred for low (LAP) alcohol preference. This positive genetic correlation between alcohol preference and FPS behavior suggests that the two traits may be functionally related...
November 23, 2016: Alcohol
https://www.readbyqxmd.com/read/27902154/the-bell-lap-stories-for-compassionate-nursing-care-murch-muriel-a-the-bell-lap-stories-for-compassionate-nursing-care-155pp-%C3%A2-16-99-crc-press-9781785231605-178523160x-formula-see-text
#3
(no author information available yet)
Key issues around ageing and care of older people are covered in this book. It offers an impressive selection of short stories that give an insight into the lives of those who can feel vulnerable when what was once 'normal' for them gradually or suddenly changes.
November 30, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27900774/paclitaxel-inhibits-post-traumatic-recurrent-laryngeal-nerve-regeneration-into-the-posterior-cricoarytenoid-muscle-in-a-canine-model
#4
Andrea M Park, Neel K Bhatt, Randal C Paniello
OBJECTIVES/HYPOTHESIS: To investigate the efficacy of paclitaxel, a potent microtubule inhibitor with a more favorable therapeutic index as compared with vincristine, in preventing post-traumatic nerve regeneration of the recurrent laryngeal nerve into the posterior cricoarytenoid muscle in a canine laryngeal model. STUDY DESIGN: Experimental animal study. METHODS: Forty-nine canine hemilaryngeal specimens were divided into five experimental groups...
November 30, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27900771/laparoscopic-guided-psoas-blockade-as-a-novel-analgesic-method-during-inguinal-herniorrhaphy-a-clinical-trial
#5
T F Tammam, A F Salama
BACKGROUND: Under laparoscopic guidance, block of ilioinguinal, iliohypogastric, and genitofemoral nerves can be possible with anesthetic injection in the plane between psoas major and the fasciae covering its anterior aspects [laparoscopic-assisted psoas (LAP) blockade]. This observer-blinded trial aimed to compare the opioid-sparing effect of LAP block with transversus abdominis plane (TAP) block after laparoscopic inguinal herniorrhaphy. METHODS: Forty-five male patients were randomly assigned to receive LAP block, group LAP (n = 23), or ultrasound-guided TAP block, group TAP (n = 22)...
November 30, 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27898988/lipid-accumulation-product-lap-as-an-index-of-metabolic-and-hormonal-disorders-in-aging-men
#6
I Rotter, A Rył, A Szylińska, W Pawlukowska, A Lubkowska, M Laszczyńska
Lipid accumulation product (LAP) is an index used for evaluating lipid overaccumulation in adults. Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) and its components, age-related testosterone deficiency syndrome (TDS), low-density cholesterol (LDL), as well as HOMA-IR (insulin resistance ratio), insulin level in non-diabetics and total testosterone (TT), estradiol E2, dehydroepiandrosterone sulphate (DHEAs) and sex hormone-binding globulin (SHBG) in aging men.313 men aged 50-75 were surveyed with regard to the prevalence of diabetes (T2DM) and hypertension (HT)...
November 29, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27897079/copper-ii-cobalt-ii-and-nickel-ii-complexes-of-lapachol-synthesis-dna-interaction-and-cytotoxicity
#7
Leila Tabrizi, Faranak Talaie, Hossein Chiniforoshan
Three novel copper(II), cobalt(II), and nickel(II) complexes of lapachol (Lap) containing 1,10-phenanthroline (phen) ligand, [M(Lap)2(phen)] (M = Cu(II), 1, Co(II), 2, and Ni(II), 3), have been synthesized and characterized using, elemental analysis and spectroscopic studies. Their interactions with calf thymus DNA (CT DNA) were investigated using viscosity, thermal denaturation, circular dichorism, fluorescence quenching, and electronic absorption spectroscopy. The DNA cleavage abilities of 1-3 have been studied, which cleavage activity of copper complex 1 is more than the complexes 2 and 3...
November 29, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27893684/ct-findings-of-small-cell-lung-carcinoma-can-recognizable-features-be-found
#8
Dongjun Lee, Ji Young Rho, Seunghun Kang, Koun Joy Yoo, Hye Jeong Choi
The purpose of this study was to clarify the recognizable computed tomography (CT) features of small cell lung carcinoma (SCLC).Contrast enhanced CT scans were reviewed retrospectively for mass location, mediastinal extension, and other concomitant findings in 142 patients with pathologically proven SCLC. SCLC was classified into hilar mass only (type I), hilar mass with ipsilateral mediastinal extension (type II), hilar mass with bilateral mediastinal extension (type III), and peripheral mass (type IV). When mediastinal lymphadenopathy (m-LAP) was indistinguishable from a hilar mass, we defined it as a mediastinal conglomerate mass (m-CM)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27893044/failure-of-the-porcine-ascending-aorta-multidirectional-experiments-and-a-unifying-microstructural-model
#9
Colleen M Witzenburg, Rohit Y Dhume, Sachin B Shah, Christopher E Korenczuk, Hallie P Wagner, Patrick W Alford, Victor H Barocas
The ascending thoracic aorta is poorly understood mechanically, especially its risk of dissection. To make better predictions of dissection risk, more information about the multi-dimensional failure behavior of the tissue is needed, and this information must be incorporated into an appropriate theoretical / computational model. Towards the creation of such a model, uniaxial, equibiaxial, peel, and shear lap tests were performed on healthy porcine ascending aorta samples. Uniaxial and equibiaxial tests showed anisotropy with greater stiffness and strength in the circumferential direction...
November 18, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27889463/noncanonical-fungal-autophagy-inhibits-inflammation-in-response-to-ifn-%C3%AE-via-dapk1
#10
Vasilis Oikonomou, Silvia Moretti, Giorgia Renga, Claudia Galosi, Monica Borghi, Marilena Pariano, Matteo Puccetti, Carlo A Palmerini, Lucia Amico, Alessandra Carotti, Lucia Prezioso, Angelica Spolzino, Andrea Finocchi, Paolo Rossi, Andrea Velardi, Franco Aversa, Valerio Napolioni, Luigina Romani
Defects in a form of noncanonical autophagy, known as LC3-associated phagocytosis (LAP), lead to increased inflammatory pathology during fungal infection. Although LAP contributes to fungal degradation, the molecular mechanisms underlying LAP-mediated modulation of inflammation are unknown. We describe a mechanism by which inflammation is regulated during LAP through the death-associated protein kinase 1 (DAPK1). The ATF6/C/EBP-β/DAPK1 axis activated by IFN-γ not only mediates LAP to Aspergillus fumigatus but also concomitantly inhibits Nod-like receptor protein 3 (NLRP3) activation and restrains pathogenic inflammation...
November 16, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27889270/does-implementing-a-general-surgery-residency-program-and-resident-involvement-affect-patient-outcomes-and-increase-care-associated-charges
#11
Trevor Wexner, Armando Rosales-Velderrain, Steven D Wexner, Raul J Rosenthal
BACKGROUND: Variable results regarding general surgery residency program (GSRP) impact on patient outcomes and charges are reported. The aim of this study was to determine any significant differences in patient outcomes and cost with a new GSRP. METHODS: We analyzed all laparoscopic appendectomies (lap-ap), cholecystectomies (lap-chole), and inguinal hernia repairs (IHR) performed before and after implementing a GRSP. RESULTS: Operative time significantly increased for lap-ap (p < 0...
November 14, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27883201/effect-of-treatment-with-5-lipoxygenase-inhibitor-via-2291-atreleuton-on-coronary-plaque-progression-a-serial-ct-angiography-study
#12
Suguru Matsumoto, Reda Ibrahim, Jean C Grégoire, Philippe L L'Allier, Josephine Pressacco, Jean-Claude Tardif, Matthew J Budoff
BACKGROUND: Inflammation has a key role in the process of atherosclerosis. Production of leukotrienes by 5-lipoxygenase has been linked to atherosclerotic plaques and cardiovascular events. HYPOTHESIS: In this study, a selective 5-LO inhibitor will slow plaque progression using serial cardiac computed tomographic angiography (CCTA). METHODS: Patients with recent acute coronary syndrome (ACS) were prospectively assigned to one of 3 VIA-2291 doses (25 mg, 50 mg, 100 mg) or placebo by oral administration...
November 24, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27882357/the-influence-of-delta-formation-mechanism-on-geotechnical-property-sequence-of-the-late-pleistocene-holocene-sediments-in-the-mekong-river-delta
#13
Truong Minh Hoang, Nguyen van Lap, Ta Thi Kim Oanh, Takemura Jiro
The aim of the study was to characterize a variety of microstructure development-levels and geotechnical property sequences of the late Pleistocene-Holocene deposits in the Mekong River delta (MRD), and the paper furthermore discusses the influences of delta formation mechanisms on them. The survey associated the geotechnical engineering and the sedimentary geology of the late Pleistocene-Holocene deposits at five sites and also undifferentiated Pleistocene sediments. A cross-section which was rebuilt in the delta progradation-direction and between the Mekong and Bassac rivers represents the stratigraphy...
November 2016: Heliyon
https://www.readbyqxmd.com/read/27880961/characterization-of-aspergillus-sojae-isolated-from-meju-korean-traditional-fermented-soybean-bricks
#14
Kyung Min Kim, Jaeho Lim, Jae Jung Lee, Byung-Serk Hurh, Inhyung Lee
Initially, we screened 18 A. sojae-like strains from Aspergillus spp. isolated from meju (Korean traditional fermented soybean bricks) according to their morphological characteristics. Because members of Aspergillus section Flavi are often incorrectly identified because of their phylogenetic similarity, we re-identified these strains at morphological and molecular genetic levels. Fourteen strains were finally identified as A. sojae. The isolates produced protease and α-amylase with ranges of 2.66-10.64 and 21...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27878621/clinical-and-functional-results-of-laparoscopic-intersphincteric-resection-for-ultralow-rectal-cancer-is-there-a-distinction-between-the-three-types-of-hand-sewn-colo-anal-anastomosis
#15
Bin Zhang, Ke Zhao, Quanlong Liu, Shuhui Yin, Guangzuan Zhuo, Yujuan Zhao, Jun Zhu, Jianhua Ding
PURPOSE: The purpose of this study is to compare the clinical and functional outcomes of three types of hand-sewn colo-anal anastomosis (CAA) after laparoscopic intersphincteric resection (Lap-ISR) for patients with ultralow rectal cancer. METHODS: A total of 79 consecutive patients treated by Lap-ISR for low-lying rectal cancer in an academic medical center from June 2011 to February 2016. According to the distal tumor margin and individualized anal length, the patients underwent three types of hand-sewn CAA including partial-ISR, subtotal-ISR, and total-ISR...
November 23, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27872181/action-experience-drives-visual-processing-biases-near-the-hands
#16
Laura E Thomas
Observers experience affordance-specific biases in visual processing for objects within the hands' grasping space, but the mechanism that tunes visual cognition to facilitate action remains unknown. I investigated the hypothesis that altered vision near the hands is a result of experience-driven plasticity. Participants performed motion-detection and form-perception tasks-while their hands were either near the display, in atypical grasping postures, or positioned in their laps-both before and after learning novel grasp affordances...
November 21, 2016: Psychological Science
https://www.readbyqxmd.com/read/27871096/responses-and-injuries-to-pmhs-in-side-facing-and-oblique-seats-in-horizontal-longitudinal-sled-tests-per-faa-emergency-landing-conditions
#17
John R Humm, Narayan Yoganandan, Frank A Pintar, Richard L DeWeese, David M Moorcroft, Amanda M Taylor, Brian Peterson
The objective of the present exploratory study is to understand occupant responses in oblique and side-facing seats in the aviation environment, which are increasingly installed in modern aircrafts. Sled tests were conducted using intact Post Mortem Human Surrogates (PMHS) seated in custom seats approximating standard aircraft geometry. End conditions were selected to represent candidate aviation seat and restraint configurations. Three-dimensional head center-of-gravity linear accelerations, head angular velocities, and linear accelerations of the T1, T6, and T12 spinous processes, and sacrum were obtained...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27866376/reduction-in-dietary-acrylamide-exposure-impact-of-potatoes-with-low-acrylamide-potential
#18
Nga L Tran, Leila M Barraj, Susan Collinge
Acrylamide forms primarily from a reaction between reducing sugars (e.g., glucose and fructose) and an amino acid (asparagine, Asn) formed naturally in foods, including potatoes. This reaction occurs when carbohydrate-rich foods are heated at temperatures above 120 °C. Multiple potato varieties were transformed with potato genomic DNA that results in down-regulation of the expression of the asparagine synthetase-1 gene (Asn1), significantly reducing synthesis of free Asn, and consequently lowering the potential to form acrylamide during cooking...
November 20, 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/27866344/development-of-a-fast-curing-tissue-adhesive-for-meniscus-tear-repair
#19
Agnieszka Izabela Bochyńska, Gerjon Hannink, Dennis Janssen, Pieter Buma, Dirk W Grijpma
Isocyanate-terminated adhesive amphiphilic block copolymers are attractive materials to treat meniscus tears due to their tuneable mechanical properties and good adhesive characteristics. However, a drawback of this class of materials is their relatively long curing time. In this study, we evaluate the use of an amine cross-linker and addition of catalysts as two strategies to accelerate the curing rates of a recently developed biodegradable reactive isocyanate-terminated hyper-branched adhesive block copolymer prepared from polyethylene glycol (PEG), trimethylene carbonate, citric acid and hexamethylene diisocyanate...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27865812/laparoscopic-adjustable-gastric-banding-versus-laparoscopic-adjustable-gastric-banding-with-gastric-plication-midterm-outcomes-in-terms-of-weight-loss-and-short-term-complications
#20
Amit Surve, Hinali Zaveri, Daniel Cottam, Christina Richards, Samuel Cottam, Austin Cottam
BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) is a safe procedure with variable outcomes and large standard deviations. LAGB with gastric plication (LAGBP) is a new restrictive procedure that combines the lap band with gastric plication. This procedure, with its mechanism being below the band anatomically, should augment the weaknesses of the lap band: slips and inadequate weight loss. OBJECTIVE: Compare the weight loss results and complication rates between the LAGB and LAGBP...
September 20, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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