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https://www.readbyqxmd.com/read/28815215/structural-characterization-of-acidic-m17-leucine-aminopeptidases-from-the-tritryps-and-evaluation-of-their-role-in-nutrient-starvation-in-trypanosoma-brucei
#1
Jennifer Timm, Maria Valente, Daniel García-Caballero, Keith S Wilson, Dolores González-Pacanowska
Leucine aminopeptidase (LAP) is found in all kingdoms of life and catalyzes the metal-dependent hydrolysis of the N-terminal amino acid residue of peptide or amino acyl substrates. LAPs have been shown to participate in the N-terminal processing of certain proteins in mammalian cells and in homologous recombination and transcription regulation in bacteria, while in parasites, they are involved in host cell invasion and provision of essential amino acids for growth. The enzyme is essential for survival in Plasmodium falciparum, where its drug target potential has been suggested...
July 2017: MSphere
https://www.readbyqxmd.com/read/28809673/heterogeneous-face-attribute-estimation-a-deep-multi-task-learning-approach
#2
Hu Han, Anil K Jain, Shiguang Shan, Xilin Chen
Face attribute estimation has many potential applications in video surveillance, face retrieval, and social media. While a number of methods have been proposed for face attribute estimation, most of them did not explicitly consider the attribute correlation and heterogeneity (e.g., ordinal vs. nominal and holistic vs. local) during feature representation learning. In this paper, we present a Deep Multi-Task Learning (DMTL) approach to jointly estimate multiple heterogeneous attributes from a single face image...
August 10, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28802886/-lumbar-artery-perforator-flap-for-breast-reconstruction
#3
J-F Honart, N Leymarie, B Sarfati, H Alknashnam, K Rem, F Rimareix, F Kolb
Even though DIEP-SIEA flaps or latissimus dorsi musculocutaneous flap are the most frequently used, a wide variety of flaps have been described for autologous breast reconstruction. Concerning the choice of donor-site, the aim is to prevent and to limit the morbidity. That is why the donor-site should be carefully chosen, according to the morphology of the patient. Lumbar artery perforator flap (LAP) is an option for breast reconstruction, but it is not well known and its use is limited. This study summarizes the authors' early experience with free LAP flap for breast reconstruction...
August 9, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28801558/visceral-adiposity-index-lipid-accumulation-product-and-intracranial-atherosclerotic-stenosis-in-middle-aged-and-elderly-chinese
#4
Rui Li, Qi Li, Min Cui, Zegang Ying, Lin Li, Tingting Zhong, Yingchao Huo, Peng Xie
We investigated the association of the newly established lipid accumulation product (LAP) and visceral adiposity index (VAI) with intracranial atherosclerotic stenosis (ICAS) in middle-aged and elderly Chinese. From June 2012 to January 2013, consecutive patients ≥40 years of age who underwent cerebral vascular imaging for various medical reasons were enrolled in this study. Multivariate logistic regression models were used to evaluate the correlation of VAI and LAP with the risk of ICAS. In total, 845 patients were included in the study...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799651/thermal-mapping-on-male-genital-and-skin-tissues-of-laptop-thermal-sources-and-electromagnetic-interaction
#5
Mahdi Safari, Navid Mosleminiya, Ali Abdolali
Since the development of communication devices and expansion of their applications, there have been concerns about their harmful health effects. The main aim of this study was to investigate laptop thermal effects caused by exposure to electromagnetic fields and thermal sources simultaneously; propose a nondestructive, replicable process that is less expensive than clinical measurements; and to study the effects of positioning any new device near the human body in steady state conditions to ensure safety by U...
August 11, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28797657/systematic-review-of-transabdominal-cerclage-placed-via-laparoscopy-for-the-prevention-of-preterm-birth
#6
REVIEW
Gaby N Moawad, Paul Tyan, Tracey Bracke, Elias D Abi Khalil, Vicky Vargas, Alexis Gimovsky, Cherie Marfori
Preterm birth is the leading cause of neonatal mortality and morbidity. Multiple interventions have been put in place to minimize this occurrence. Despite current recommendations including medical management, cervical length screening, and transvaginal cerclage a substantial number of women still experience preterm birth. For those patients, experts recommend a transabdominal cerclage. In our systematic review, we compare 26 studies (1116 patients) on transabdominal cerclage placed via laparotomy (TAC-lap) to 15 studies (728 patients) on transabdominal cerclage placed via laparoscopy (TAC-lsc)...
August 7, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28796129/pacing-profiles-and-competitive-performance-of-elite-female-400-m-freestyle-swimmers
#7
Patrycja Lipinska, Will G Hopkins
Pacing can impact competitive endurance performance. The objective of this study was to determine relationships between pacing parameters and competitive performance of elite female 400-m freestyle swimmers. Publicly available websites provided 50-m split and final times for 381 swims of 20 elite female swimmers in over 150 national and international competitions between 2004 and 2016. Most pacing profiles displayed negative quadratic curvature, with the fifth of the eight laps being the median slowest. The mean times for the first and last laps were faster than predicted by the quadratic by 5...
August 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28795730/role-of-garp-in-the-activation-of-latent-tgf-%C3%AE-1
#8
REVIEW
Julie Stockis, Olivier Dedobbeleer, Sophie Lucas
TGF-β1, 2 and 3 cytokines are involved in many cellular processes including cell proliferation, differentiation, migration and survival. Whereas TGF-β2 and 3 play important roles in embryonic development, TGF-β1 is mostly implicated in controlling immune responses after birth. The production of TGF-β1 is a tightly regulated process, occurring mostly at a post-translational level. Virtually all cells produce the latent, inactive form of TGF-β1. In latent TGF-β1, the mature TGF-β1 dimer is non-covalently associated to the Latency Associated Peptide, or LAP, which prevents binding to the TGF-β1 receptor...
August 10, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28790884/the-effect-of-electroencephalogram-eeg-reference-choice-on-information-theoretic-measures-of-the-complexity-and-integration-of-eeg-signals
#9
Logan T Trujillo, Candice T Stanfield, Ruben D Vela
Converging evidence suggests that human cognition and behavior emerge from functional brain networks interacting on local and global scales. We investigated two information-theoretic measures of functional brain segregation and integration-interaction complexity C I (X), and integration I(X)-as applied to electroencephalographic (EEG) signals and how these measures are affected by choice of EEG reference. CI(X) is a statistical measure of the system entropy accounted for by interactions among its elements, whereas I(X) indexes the overall deviation from statistical independence of the individual elements of a system...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28777468/technical-note-a-novel-quality-assurance-test-to-identify-gantry-angle-inaccuracies-in-respiratory-gated-vmat-treatments
#10
Emily Hubley, Michael Briscoe, Nicolas Ploquin, Greg Pierce
PURPOSE: During respiratory-gated volumetric modulated arc therapy (VMAT), the radiation beam is turned off each time the target exits the gating window. At the same time, the gantry slows, stops, and rewinds before the beam is turned back on. A quality assurance (QA) test was developed to detect inaccuracies in the gantry angle position between beam-off and beam-on events during respiratory-gated VMAT. METHODS: Strips of Gafchromic(™) EBT3 film were taped to the surface of a Capthan(®) 504 phantom mounted at isocentre...
August 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28773810/thermo-mechanical-characterization-of-friction-stir-spot-welded-aa7050-sheets-by-means-of-experimental-and-fem-analyses
#11
Gianluca D'Urso, Claudio Giardini
The present study was carried out to evaluate how the friction stir spot welding (FSSW) process parameters affect the temperature distribution in the welding region, the welding forces and the mechanical properties of the joints. The experimental study was performed by means of a CNC machine tool obtaining FSSW lap joints on AA7050 aluminum alloy plates. Three thermocouples were inserted into the samples to measure the temperatures at different distance from the joint axis during the whole FSSW process. Experiments was repeated varying the process parameters, namely rotational speed, axial feed rate and plunging depth...
August 11, 2016: Materials
https://www.readbyqxmd.com/read/28773800/design-of-friction-stir-spot-welding-tools-by-using-a-novel-thermal-mechanical-approach
#12
Zheng-Ming Su, Qi-Hong Qiu, Pai-Chen Lin
A simple thermal-mechanical model for friction stir spot welding (FSSW) was developed to obtain similar weld performance for different weld tools. Use of the thermal-mechanical model and a combined approach enabled the design of weld tools for various sizes but similar qualities. Three weld tools for weld radii of 4, 5, and 6 mm were made to join 6061-T6 aluminum sheets. Performance evaluations of the three weld tools compared fracture behavior, microstructure, micro-hardness distribution, and welding temperature of welds in lap-shear specimens...
August 9, 2016: Materials
https://www.readbyqxmd.com/read/28773003/lamb-wave-damage-quantification-using-ga-based-ls-svm
#13
Fuqiang Sun, Ning Wang, Jingjing He, Xuefei Guan, Jinsong Yang
Lamb waves have been reported to be an efficient tool for non-destructive evaluations (NDE) for various application scenarios. However, accurate and reliable damage quantification using the Lamb wave method is still a practical challenge, due to the complex underlying mechanism of Lamb wave propagation and damage detection. This paper presents a Lamb wave damage quantification method using a least square support vector machine (LS-SVM) and a genetic algorithm (GA). Three damage sensitive features, namely, normalized amplitude, phase change, and correlation coefficient, were proposed to describe changes of Lamb wave characteristics caused by damage...
June 12, 2017: Materials
https://www.readbyqxmd.com/read/28772886/experimental-investigation-on-laser-impact-welding-of-fe-based-amorphous-alloys-to-crystalline-copper
#14
Xiao Wang, Yapeng Luo, Tao Huang, Huixia Liu
Recently, amorphous alloys have attracted many researchers' attention for amorphous structures and excellent properties. However, the welding of amorphous alloys to traditional metals in the microscale is not easy to realize in the process with amorphous structures unchanged, which restrains the application in industry. In this paper, a new method of welding Fe-based amorphous alloys (GB1K101) to crystalline copper by laser impact welding (LIW) is investigated. A series of experiments was conducted under different laser energies, during which Fe-based amorphous alloys and crystalline copper were welded successfully by LIW...
May 12, 2017: Materials
https://www.readbyqxmd.com/read/28772809/microstructure-and-mechanical-properties-of-an-ultrasonic-spot-welded-aluminum-alloy-the-effect-of-welding-energy
#15
He Peng, Daolun Chen, Xianquan Jiang
The aim of this study is to evaluate the microstructures, tensile lap shear strength, and fatigue resistance of 6022-T43 aluminum alloy joints welded via a solid-state welding technique-ultrasonic spot welding (USW)-at different energy levels. An ultra-fine necklace-like equiaxed grain structure is observed along the weld line due to the occurrence of dynamic crystallization, with smaller grain sizes at lower levels of welding energy. The tensile lap shear strength, failure energy, and critical stress intensity of the welded joints first increase, reach their maximum values, and then decrease with increasing welding energy...
April 25, 2017: Materials
https://www.readbyqxmd.com/read/28772553/the-effect-of-welding-energy-on-the-microstructural-and-mechanical-properties-of-ultrasonic-welded-copper-joints
#16
Jingwei Yang, Biao Cao, Qinghua Lu
The effects of welding energy on the mechanical and microstructural characteristics of ultrasonic-welded pure copper plates were investigated. Complex dynamic recrystallization and grain growth occurred inside the weld zone during ultrasonic welding. At a low welding energy, a thin band of straight weld interfaces was observed and had an ultra-fine grain structure. With an increase in welding energy, the weld interface progressively changed from flat to sinusoidal, and eventually turned into a convoluted wavy pattern, bearing similarities to shear instabilities, as observed in fluid dynamics...
February 16, 2017: Materials
https://www.readbyqxmd.com/read/28772545/on-the-process-related-rivet-microstructural-evolution-material-flow-and-mechanical-properties-of-ti-6al-4v-gfrp-friction-riveted-joints
#17
Natascha Z Borba, Conrado R M Afonso, Lucian Blaga, Jorge F Dos Santos, Leonardo B Canto, Sergio T Amancio-Filho
In the current work, process-related thermo-mechanical changes in the rivet microstructure, joint local and global mechanical properties, and their correlation with the rivet plastic deformation regime were investigated for Ti-6Al-4V (rivet) and glass-fiber-reinforced polyester (GF-P) friction-riveted joints of a single polymeric base plate. Joints displaying similar quasi-static mechanical performance to conventional bolted joints were selected for detailed characterization. The mechanical performance was assessed on lap shear specimens, whereby the friction-riveted joints were connected with AA2198 gussets...
February 15, 2017: Materials
https://www.readbyqxmd.com/read/28771061/comparison-of-performance-levels-and-sex-on-sprint-race-performance-in-the-biathlon-world-cup
#18
Harri Luchsinger, Jan Kocbach, Gertjan Ettema, Øyvind Sandbakk
Biathlon is an Olympic sport combining cross-country skiing with the skating technique and rifle shooting. The sprint (7.5 km for women and 10 km for men) includes two shootings between the three laps of skiing. The aims of the current study are to compare biathletes of different performance-levels and sex on total race time and performance-determining factors of sprint races in the biathlon World Cup. The top 10-performers (G1-10) and results within rank 21-30 (G21-30) in 47 sprint races during the 2011/2012 to 2015/2016 World Cup seasons were compared regarding total race time, course time, shooting time, range time, shooting performance (rate of hits) and penalty time...
August 3, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28763794/targeting-latency-associated-peptide-promotes-antitumor-immunity
#19
Galina Gabriely, Andre P da Cunha, Rafael M Rezende, Brendan Kenyon, Asaf Madi, Tyler Vandeventer, Nathaniel Skillin, Stephen Rubino, Lucien Garo, Maria A Mazzola, Panagiota Kolypetri, Amanda J Lanser, Thais Moreira, Ana Maria C Faria, Hans Lassmann, Vijay Kuchroo, Gopal Murugaiyan, Howard L Weiner
Regulatory T cells (Tregs) promote cancer by suppressing antitumor immune responses. We found that anti-LAP antibody, which targets the latency-associated peptide (LAP)/transforming growth factor-β (TGF-β) complex on Tregs and other cells, enhances antitumor immune responses and reduces tumor growth in models of melanoma, colorectal carcinoma, and glioblastoma. Anti-LAP decreases LAP(+) Tregs, tolerogenic dendritic cells, and TGF-β secretion and is associated with CD8(+) T cell activation. Anti-LAP increases infiltration of tumors by cytotoxic CD8(+) T cells and reduces CD103(+) CD8 T cells in draining lymph nodes and the spleen...
May 19, 2017: Science Immunology
https://www.readbyqxmd.com/read/28763504/full-course-macro-kinematic-analysis-of-a-10-km-classical-cross-country-skiing-competition
#20
Finn Marsland, Colin Mackintosh, Hans-Christer Holmberg, Judith Anson, Gordon Waddington, Keith Lyons, Dale Chapman
In this study micro-sensors were employed to analyse macro-kinematic parameters during a classical cross-country skiing competition (10 km, 2-lap). Data were collected from eight male participants during the Australian championship competition wearing a single micro-sensor unit (MinimaxX™, S4) positioned on their upper back. Algorithms and visual classification were used to identify skiing sub-techniques and calculate velocities, cycle lengths (CL) and cycle rates (CR) over the entire course. Double poling (DP) was the predominant cyclical sub-technique utilised (43 ± 5% of total distance), followed by diagonal stride (DS, 16 ± 4%) and kick double poling (KDP, 5 ± 4%), with the non-propulsive Tuck technique accounting for 24 ± 4% of the course...
2017: PloS One
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