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https://www.readbyqxmd.com/read/28110072/structuring-of-composite-hydrogel-bioadhesives-and-its-effect-on-properties-and-bonding-mechanism
#1
Oded Pinkas, Daniella Goder, Roni Noyvirt, Sivan Peleg, Maayan Kahlon, Meital Zilberman
: Bioadhesives are polymeric hydrogels that can adhere to a tissue after crosslinking and are an essential element in nearly all surgeries worldwide. Several bioadhesives are commercially available. However, none of them are ideal. The main limitation of current tissue adhesives is the tradeoff between biocompatibility and mechanical strength, especially in wet hemorrhagic environments. Our novel bioadhesives are based on the natural polymers gelatin (coldwater fish) and alginate, crosslinked by carbodiimide (EDC)...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28107375/narcolepsy-type-1-is-associated-with-a-systemic-increase-and-activation-of-regulatory-t-cells-and-with-a-systemic-activation-of-global-t-cells
#2
Michel Lecendreux, Guillaume Churlaud, Fabien Pitoiset, Armelle Regnault, Tu Anh Tran, Roland Liblau, David Klatzmann, Michelle Rosenzwajg
Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons with patients typically showing low CSF-hypocretin levels (<110 pg/ml). This specific loss of hypocretin and the strong association with the HLA-DQB1*06:02 allele led to the hypothesis that NT1 could be an immune-mediated pathology. Moreover, susceptibility to NT1 has recently been associated with several pathogens, particularly with influenza A H1N1 virus either through infection or vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/28103600/indicators-of-adiposity-predictors-of-metabolic-syndrome-in-the-elderly
#3
Carolina Cunha de Oliveira, Anna Karla C Roriz, Lilian B Ramos, Mansueto Gomes Neto
BACKGROUND: Adiposity indicators can be used as predictors of cardiovascular risk in the elderly. However, there are only a very few studies that deal with the accuracy of adiposity indicators as predictors of metabolic syndrome (MS) in the elderly. We evaluated the performance of adiposity indicators of MS prediction in the elderly. METHODS: A cross-sectional study with 203 elderly people of both genders. VARIABLES: MS defined by harmonized criteria, waist circumference (WC), waist-to-height ratio (WHtR), conicity index (CI), lipid accumulation product (LAP), and visceral adiposity index (VAI)...
January 20, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28100123/relay-exchanges-in-elite-short-track-speed-skating
#4
Andrew Hext, Ben Heller, John Kelley, Simon Goodwill
In short track speed skating, the relay exchange provides an additional strategic component to races by allowing a team to change the skater involved in the pack race. Typically executed every 1½ laps, it is the belief of skaters and coaches that during this period of the race, time can be gained or lost due to the execution of the relay exchange. As such, the aim of this study was to examine the influence of the relay exchange on a team's progression through a 5000 m relay race. Using data collected from three World Cup relay events during the 2012-2013 season, the time taken to complete the straight for the scenarios with and without the relay exchange were compared at different skating speeds for the corner exit prior to the straight...
January 18, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28099959/fecal-volume-after-laparoscopic-low-anterior-resection-predicts-anastomotic-leakage
#5
Eiji Hidaka, Chiyo Maeda, Kenta Nakahara, Shoji Shimada, Shumpei Mukai, Naruhiko Sawada, Fumio Ishida, Shin-Ei Kudo
BACKGROUND/AIM: Anastomotic leakage (AL) is a major complication after laparoscopic low anterior resection (Lap-LAR). Many surgeons encounter AL following severe postoperative diarrhea. However, little is known about the relationship between postoperative fecal volume and AL. This study determined whether postoperative fecal volume can predict AL. METHODS: A retrospective assessment was performed with data from 176 patients with rectal cancers who underwent Lap-LAR between April 2011 and August 2015...
January 19, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28065859/inhibition-of-human-udp-glucuronosyltransferase-enzymes-by-lapatinib-pazopanib-regorafenib-and-sorafenib-implications-for-hyperbilirubinemia
#6
John O Miners, Nuy Chau, Andrew Rowland, Kushari Burns, Ross A McKinnon, Peter I Mackenzie, Geoffrey T Tucker, Kathleen M Knights, Ganessan Kichenadasse
Kinase inhibitors (KIs) are a rapidly expanding class of drugs used primarily for the treatment of cancer. Data relating to the inhibition of UDP-glucuronosyltransferase (UGT) enzymes by KIs is sparse. However, lapatinib (LAP), pazopanib (PAZ), regorafenib (REG) and sorafenib (SOR) have been implicated in the development of hyperbilirubinemia in patients. This study aimed to characterise the role of UGT1A1 inhibition in hyperbilirubinemia and assess the broader potential of these drugs to perpetrate drug-drug interactions arising from UGT enzyme inhibition...
January 6, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28065317/preparation-of-centralspindlin-as-an-active-heterotetramer-of-kinesin-and-gtpase-activating-protein-subunits-for-in-vitro-structural-and-functional-assays
#7
M Mishima
Centralspindlin is a crucial regulator of animal cytokinesis, consisting of MKLP1 kinesin-6 and CYK4 Rho-family GTPase activating protein (RhoGAP). As a microtubule-bundling protein, it plays a crucial role in the formation of the central spindle. Through distinct accumulation to the antiparallel microtubule overlaps at the central spindle and the midbody, it recruits various downstream factors to the site of cell division as well as anchors the plasma membrane to maintain the narrow intercellular channels between the daughter cells until their final separation (abscission)...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28064495/photophysical-behavior-of-isocyanine-clay-hybrids-in-the-solid-state-%C3%A2
#8
Silvano R Valandro, Alessandra L Poli, Thaís F A Correia, Patricia C Lombardo, Carla C Schmitt
In the present study, we have attempted to investigate, for the first time, the photophysical behavior of 1,1'-diethyl-2,4'-cyanine (ICY)/clay mineral hybrids in the solid state. The effects promoted by ICY loading and clay type on the spectroscopic properties were studied by UV-vis diffuse reflectance spectroscopy (DR) and different fluorescence techniques. The hybrids were characterized by X-ray diffraction (XRD) and thermogravimetric analysis (TGA). UV-vis-DR revealed the formation of ICY H-aggregates in Wyoming montmorillonite (SWy-1) and Laponite (Lap); however, J-aggregates were predominant for ICY on Arizona (SAz-1) and Barasym (SYn-1) montmorillonites...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28062364/ph-sensitive-dexamethasone-encapsulated-laponite-nanoplatelets-release-mechanism-and-cytotoxicity
#9
M Roozbahani, M Kharaziha, R Emadi
The purpose of this study was to develop an efficient strategy to use laponite (LAP) nanoplates as a platform for the efficient release of anionic dexamethasone (DEX). Results revealed that DEX was encapsulated into the interlayer space of LAP nanodisks through an intercalation process with a high loading efficiency of 95.10±0.80%. X-Ray diffraction (XRD) patterns and Fourier transform infrared (FTIR) spectra of the hybrid LAP/DEX nanoplates (LD-NPs) indicated that DEX molecules could successfully adsorb into the LAP nanoplates depending on the pH value...
January 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28061550/the-watertightness-of-the-anastomosis-after-laparoscopic-or-robot-assisted-pyeloplasty-is-a-drainage-necessary
#10
Annika Ruehle, Emilio Arbelaez, Agostino Mattei, Hansjörg Danuser
OBJECTIVE: To determine whether or not temporary drainage is necessary immediately following laparoscopic (lap) and robot-assisted (rob) pyeloplasty (PP). METHODS: Of 99 patients undergoing lap PP (n=23) or rob PP (n=76) for treatment of ureteropelvic junction obstruction (UPJO), 52 had no drainage, 47 were given an "easy flow" drain (EFD). The volume of leaking urine (in ml) was defined as the volume of drainage fluid (in ml) x creatinine concentration in drainage fluid (in μmol/ml) / median urine creatinine concentration (in μmol/ml)...
January 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28060263/inducible-lap-tagged-stable-cell-lines-for-investigating-protein-function-spatiotemporal-localization-and-protein-interaction-networks
#11
Michelle Bradley, Ivan Ramirez, Keith Cheung, Ankur A Gholkar, Jorge Z Torres
Multi-protein complexes, rather than single proteins acting in isolation, often govern molecular pathways regulating cellular homeostasis. Based on this principle, the purification of critical proteins required for the functioning of these pathways along with their native interacting partners has not only allowed the mapping of the protein constituents of these pathways, but has also provided a deeper understanding of how these proteins coordinate to regulate these pathways. Within this context, understanding a protein's spatiotemporal localization and its protein-protein interaction network can aid in defining its role within a pathway, as well as how its misregulation may lead to disease pathogenesis...
December 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28058772/suaahara-in-nepal-an-at-scale-multi-sectoral-nutrition-program-influences-knowledge-and-practices-while-enhancing-equity
#12
Kenda Cunningham, Akriti Singh, Pooja Pandey Rana, Laura Brye, Bindu Gautam, Karin Lapping, Silvia Alayon, Carol Underwood, Rolf D W Klemm
The burden of undernutrition in South Asia is greater than anywhere else. Policies and programmatic efforts increasingly address health and non-health determinants of undernutrition. In Nepal, one large-scale integrated nutrition program, Suaahara, aimed to reduce undernutrition among women and children in the 1,000-day period, while simultaneously addressing inequities. In this study, we use household-level process evaluation data (N = 480) to assess levels of exposure to program inputs and levels of knowledge and practices related to health, nutrition, and water, sanitation, and hygiene (WASH)...
January 6, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28048471/su-g-jep3-03-effect-of-robot-pose-on-beam-blocking-for-ultrasound-guided-sbrt-of-the-prostate
#13
S Gerlach, I Kuhlemann, F Ernst, C Fuerweger, A Schlaefer
PURPOSE: Ultrasound presents a fast, volumetric image modality for real-time tracking of abdominal organ motion. How-ever, ultrasound transducer placement during radiation therapy is challenging. Recently, approaches using robotic arms for intra-treatment ultrasound imaging have been proposed. Good and reliable imaging requires placing the transducer close to the PTV. We studied the effect of a seven degrees of freedom robot on the fea-sible beam directions. METHODS: For five CyberKnife prostate treatment plans we established viewports for the transducer, i...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047354/su-f-t-77-a-novel-test-for-coincidence-between-light-fields-and-electron-radiation-fields
#14
G Gibbard, C Shang, S Khanal
PURPOSE: To validate a novel real time quality assurance device, as a means to test coincidence of light fields to electron radiation fields. METHOD AND MATERIALS: Use a Raven™ (LAP of America Laser Applications) detector, both light fields and electron radiation fields of various electron cones and cutouts from two Clinacs (Varian Medical) were sensed by the phosphor screen and registered by a CCD camera of the device. During measurements, the screen surface of Raven was placed at ISO center level facing the radiation field at any setup angle...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046954/su-f-t-556-a-potential-real-time-aqa-for-cyberknife-cones-and-mlc-based-treatments
#15
C Shang, G Gibbard, J Cole, A Schramm, T Leventouri, S Khanal
PURPOSE: To investigate the potential use of the Raven™ (LAP of America Laser Applications) for real time AQA of Cyberknife™ with InCise2 MLC (Accuray™ Medical). METHODS: At setup, the Raven was rotated 45° on which an Accuray™ AQA cube was positioned. Three different AQA plans for fixed cone, InCise2MLC, and a modified MLC plan were delivered repeatedly ten times. The additional shapes in modified AQA plan enable additional reproducibility checks for all the MLC pairs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046741/su-f-j-87-impact-of-the-dosimetric-consequences-from-minimal-displacements-throughout-the-treatment-time-in-apbi-with-savi-applicators
#16
S Chandrasekara, S Pella, M Hyvarinen, J Pinder
PURPOSE: To assess the variation in dose received by the organs at risk (OARs) due to inter-fractional motion by SAVI to determine the importance of providing proper immobilization METHODS: An analysis of 15 patients treated with SAVI applicators were considered for this study. Treatment planning teams did not see significant changes in their CT scans through scout images and initial treatment plan was used for the entire treatment. These scans, taken before each treatment were imported in to the treatment planning system and were fused together with respective to the applicator, using landmark registration...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046621/su-f-t-287-a-preliminary-study-on-patient-specific-vmat-verification-using-a-phosphor-screen-based-geometric-qa-system-raven-qa
#17
M Lee, J Wong, K Ding, B Yi
PURPOSE: The RavenQA system (LAP Laser, Germany) is a QA device with a phosphor screen detector for performing the QA tasks of TG-142. This study tested if it is feasible to use the system for the patient specific QA of the Volumetric Modulated Arc Therapy (VMAT). METHODS: Water equivalent material (5cm) is attached to the front of the detector plate of the RavenQA for dosimetry purpose. Then the plate is attached to the gantry to synchronize the movement between the detector and the gantry...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039301/il-6-inhibits-upregulation-of-membrane-bound-tgf-%C3%AE-1-on-cd4-t-cells-and-blocking-il-6-enhances-oral-tolerance
#18
Chantal Kuhn, Rafael Machado Rezende, Hanane M'Hamdi, Andre Pires da Cunha, Howard L Weiner
Oral administration of Ag induces regulatory T cells that express latent membrane-bound TGF-β (latency-associated peptide [LAP]) and have been shown to play an important role in the induction of oral tolerance. We developed an in vitro model to study modulation of LAP(+) on CD4(+) T cells. The combination of anti-CD3 mAb, anti-CD28 mAb, and recombinant IL-2 induced expression of LAP on naive CD4(+) T cells, independent of Foxp3 or exogenous TGF-β. In vitro generated CD4(+)LAP(+)Foxp3(-) T cells were suppressive in vitro, inhibiting proliferation of naive CD4(+) T cells and IL-17A secretion by Th17 cells...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28033718/maintained-physical-activity-induced-changes-in-delay-discounting
#19
Michael J Sofis, Ale Carrillo, David P Jarmolowicz
Those who discount the subjective value of delayed rewards less steeply are more likely to engage in physical activity. There is limited research, however, showing whether physical activity can change rates of delay discounting. In a two-experiment series, treatment and maintenance effects of a novel, effort-paced physical activity intervention on delay discounting were evaluated with multiple baseline designs. Using a lap-based method, participants were instructed to exercise at individualized high and low effort levels and to track their own perceived effort...
December 1, 2016: Behavior Modification
https://www.readbyqxmd.com/read/28033030/kinesthetic-imagery-provides-additive-benefits-to-internal-visual-imagery-on-slalom-task-performance
#20
Nichola Callow, Dan Jiang, Ross Roberts, Martin G Edwards
Recent brain imaging research demonstrates that the use of internal visual imagery (IVI) or kinesthetic imagery (KIN) activates common and distinct brain areas. In this paper we argue that combining the imagery modalities (IVI & KIN) will lead to a greater cognitive representation (with more brain areas activated), and this will cause a greater slalom-based motor performance compared to when using IVI alone. To examine this assertion, we randomly allocated 56 participants to one of three groups: IVI, IVI & KIN, or a math-control...
December 29, 2016: Journal of Sport & Exercise Psychology
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