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https://www.readbyqxmd.com/read/29760217/temporal-manipulation-of-mitochondrial-function-by-virulent-francisella-tularensis-to-limit-inflammation-and-control-cell-death
#1
Forrest Jessop, Benjamin Schwarz, Emily Heitmann, Robert Buntyn, Tara Wehrly, Catharine M Bosio
Francisella tularensis ssp tularensis (Ftt) is a highly pathogenic intracellular bacterium that suppresses host inflammation by impairing the metabolic shift from oxidative phosphorylation to glycolysis. Decreased mitochondrial metabolism is central to initiating a metabolic shift to glycolysis and regulating inflammation, but Ftt manipulation of host mitochondrial function has not been explored. We demonstrate using extracellular flux analysis that Ftt infection initially improves host macrophage mitochondrial bioenergetics in a capsule dependent manner...
May 14, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29730659/myxedema-coma-due-to-hashimoto-thyroiditis-a-rare-but-real-presentation-of-failure-to-thrive-in-infancy
#2
Ryan A Heksch, Rohan K Henry
BACKGROUND: Hashimoto thyroiditis (HT) is uncommon in infancy, and myxedema coma (MC) is even less common. While prior reports have documented these entities separately, to our knowledge, MC in combination with HT has not been reported before in this age group. METHODS/RESULTS: A 10-month-old female presented with ptosis, lethargy, dysphagia, and failure to thrive (FTT). She developed hypotension, bradycardia, hypothermia, and apnea requiring intubation. Initial thyroid-stimulating hormone was 422 μIU/mL, and free thyroxine was < 0...
May 4, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29730059/nasotracheal-intubation-the-preferred-airway-in-oral-cavity-microvascular-reconstructive-surgery
#3
Jordan Gigliotti, Godwin Cheung, Omar Suhaym, Ramanakumar V Agnihotram, Michel El-Hakim, Nicholas Makhoul
PURPOSE: We aimed to describe the safety and effectiveness of nasotracheal intubation (NTI) in a cohort of patients undergoing reconstruction of oral cavity defects with free tissue transfer (FTT). MATERIALS AND METHODS: We implemented a retrospective cohort study and enrolled a sample composed of consecutive patients undergoing FTT reconstruction of oral cavity, maxillary, or mandibular defects between 2013 and 2017. These patients were all subject to a newly developed enhanced recovery-after-surgery protocol...
April 11, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29589983/a-quality-improvement-initiative-to-improve-feeding-and-growth-of-infants-with-cleft-lip-and-or-palate
#4
Adriane L Baylis, Gregory D Pearson, Courtney Hall, Lauren L Madhoun, Caitlin Cummings, Nancy Neal, Amanda Smith, Katherine Eastman, Christina Stocker, Richard E Kirschner
OBJECTIVE: The purpose of this quality improvement initiative was to improve feeding and growth outcomes in infants with cleft lip and/or palate (CL/P). DESIGN: Institute for Healthcare Improvement quality improvement model. SETTING: Large pediatric academic medical center in the Midwestern United States. PARTICIPANTS: One hundred forty-five infants with nonsyndromic CL/P ages 0 to 12 months. INTERVENTIONS: Key drivers included (1) caregiver education and resources, (2) care coordination and flow, and (3) provider education and training...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29538787/behavioral-outbursts-in-a-child-with-a-deletion-syndrome-generalized-epilepsy-global-developmental-delay-and-failure-to-thrive
#5
Adam H Lewis, Ankur Chugh, Sarah A Sobotka
A 7-year-old girl with 20q13.33 deletion and a history of generalized convulsive epilepsy presented to the Developmental and Behavioral Pediatrics Clinic due to concerns about her behavioral outbursts in the context of overall delayed development. Evaluation by the Developmental and Behavioral and Gastroenterology teams revealed failure to thrive (FTT) as the primary cause of the behavioral outbursts and developed a high-calorie, high-fat, high-protein nutritional counseling plan. Children who have FTT and a genetic disorder are often thought to not thrive because of their underlying genetic disorder; however, feeding skills and nutritional intake need to be thoroughly investigated before determining an etiology for FTT...
March 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29520190/evaluation-of-the-subscapularis-tendon-tears-on-3t-magnetic-resonance-arthrography-comparison-of-diagnostic-performance-of-t1-weighted-spectral-presaturation-with-inversion-recovery-and-t2-weighted-turbo-spin-echo-sequences
#6
Hoseok Lee, Joong Mo Ahn, Yusuhn Kang, Joo Han Oh, Eugene Lee, Joon Woo Lee, Heung Sik Kang
Objective: To compare the T1-weighted spectral presaturation with inversion-recovery sequences (T1 SPIR) with T2-weighted turbo spin-echo sequences (T2 TSE) on 3T magnetic resonance arthrography (MRA) in the evaluation of the subscapularis (SSC) tendon tear with arthroscopic findings as the reference standard. Materials and Methods: This retrospective study included 120 consecutive patients who had undergone MRA within 3 months between April and December 2015. Two musculoskeletal radiologists blinded to the arthroscopic results evaluated T1 SPIR and T2 TSE images in separate sessions for the integrity of the SSC tendon, examining normal/articular-surface partial-thickness tear (PTTa)/full-thickness tear (FTT)...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29509829/fluorescein-transit-test-time-as-a-tool-to-assess-lacrimal-pump-function-after-diode-laser-transcanalicular-dacryocystorhinostomy-and-external-dacryocysto-rhinostomy
#7
E D Feijo, R M Limongi, S Matayoshi
BACKGROUND: Dacryocystorhinostomy (DCR) is the gold standard surgical treatment for nasolacrimal duct obstruction. External DCR is the traditional approach (EXT-DCR); however, the advent of minimally invasive surgeries and the development of optic fiber and laser technologies have made it possible to perform laser transcanalicular DCR (T-DCR), a minimally invasive procedure. This study measured the fluorescein transit time (FTT) after EXT-DCR or T-DCR to evaluate the lacrimal drainage and lacrimal pump function after these two types of DCR...
March 6, 2018: Rhinology
https://www.readbyqxmd.com/read/29461427/educational-effectiveness-of-an-easily-made-new-simulator-model-for-ultrasound-guided-vascular-access-and-foreign-body-management-procedures-on-pediatric-patients
#8
Ikwan Chang, Young Ho Kwak, Do Kyun Kim, Jin Hee Lee, Jae Yun Jung, Hyuksool Kwon, Jin Hee Jung, Bongjin Lee, So Hyun Paek
OBJECTIVES: This study aimed to introduce an easily made chicken breast simulator for ultrasound (US)-guided vascular access, foreign body (FB) detection, and hydrodissection in pediatric patients and to validate the effectiveness for training using this phantom tissue model. METHODS: The authors made the tissue phantom simulator using a chicken breast and rubber tourniquet for vascular access and fragments of a tongue blade and steel clip for FB detection and hydrodissection using a very simple method...
February 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29326860/retroperitoneal-mass-masquerading-as-failure-to-thrive-in-a-91-year-old-woman
#9
Gabriel O Ologun, Noel Yarze, David Bertsch, Joseph Mwesige
Failure to thrive (FTT) is a state of overall decline. Patients often present with weight loss, poor appetite, malnutrition, and decreased physical functioning. The etiology is multifactorial including chronic diseases, functional impairments, and acute illnesses. Evaluation for reversible causes is paramount, and treatment is aimed at maintaining or improving functional status. We present a case of a 91-year-old woman with a retroperitoneal mass that was found on workup for failure to thrive.
November 8, 2017: Curēus
https://www.readbyqxmd.com/read/29324723/error-recovery-in-the-time-triggered-paradigm-with-ftt-can
#10
Luis Marques, Verónica Vasconcelos, Paulo Pedreiras, Luís Almeida
Data networks are naturally prone to interferences that can corrupt messages, leading to performance degradation or even to critical failure of the corresponding distributed system. To improve resilience of critical systems, time-triggered networks are frequently used, based on communication schedules defined at design-time. These networks offer prompt error detection, but slow error recovery that can only be compensated with bandwidth overprovisioning. On the contrary, the Flexible Time-Triggered (FTT) paradigm uses online traffic scheduling, which enables a compromise between error detection and recovery that can achieve timely recovery with a fraction of the needed bandwidth...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29249548/patients-with-a-long-standing-cuff-tear-in-one-shoulder-have-high-rates-of-contralateral-cuff-tears-a-study-of-patients-with-arthroscopically-verified-cuff-tears-22-years-ago
#11
Mats C Ranebo, Hanna C Björnsson Hallgren, Lars E Adolfsson
BACKGROUND: The prevalence of contralateral full-thickness cuff tears (FTTs) and cuff tear arthropathy (CTA) is presumed to be higher in patients with long-standing cuff tears than in those with newly diagnosed tears, but data are currently lacking. METHODS: Sixty-one patients with 38 partial and 23 full-thickness tears of 1 shoulder at arthroscopy were examined with bilateral radiographs, ultrasound, and the Constant-Murley score at a mean of 22 years (range, 21-25 years) after arthroscopy...
March 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29210612/association-of-fine-motor-loss-and-allodynia-in-fibromyalgia-an-fnirs-study
#12
Aykut Eken, Didem Gökçay, Cemre Yılmaz, Bora Baskak, Ayşegül Baltacı, Murat Kara
Recent studies showed that fine motor control dysfunction was observed in fibromyalgia (FM) syndrome as well as allodynia. However, brain signatures of this association still remain unclear. In this study, finger tapping task (FTT) and median nerve stimulation (MNS) were applied to both hands of 15 FM patients and healthy controls (HC) to understand this relationship. Hemodynamic activity was measured simultaneously using functional near-infrared spectroscopy (fNIRS). Experiments were analyzed separately by using 2x2 repeated measures ANOVA...
December 6, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29209459/effects-of-zinc-supplementation-on-catch-up-growth-in-children-with-failure-to-thrive
#13
Seul-Gi Park, Ha-Neul Choi, Hye-Ran Yang, Jung-Eun Yim
BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT. SUBJECTS/METHODS: In this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months...
December 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29200470/market-versus-residence-principle-experimental-evidence-on-the-effects-of-a-financial-transaction-tax
#14
Jürgen Huber, Michael Kirchler, Daniel Kleinlercher, Matthias Sutter
The effects of a financial transaction tax (FTT) are scientifically disputed, as seemingly small details of its implementation may matter a lot. In this article, we provide experimental evidence on the different effects of an FTT, depending on whether it is implemented as a tax on markets, on residents, or a combination of both. We find that a tax on markets has negative effects on volatility and trading volume, whereas a tax on residents shows none of these undesired effects. Additionally, we observe that individual risk attitude is not related to traders' reaction to the different forms of an FTT...
October 2017: Economic Journal
https://www.readbyqxmd.com/read/29184735/association-of-high-volume-surgeons-working-in-high-volume-hospitals-with-cost-of-free-flap-surgeries
#15
Elham Mahmoudi, Yiwen Lu, Shu-Chen Chang, Chia-Yu Lin, Yi-Chun Wang, Chee Jen Chang, Ming-Huei Cheng, Kevin C Chung
Background: We examined the associations of surgeon and hospital volume with total cost, length of stay (LOS), and cost per day for free tissue transfer (FTT) surgeries. Evidence demonstrates a higher likelihood of success for FTT in higher volume hospitals. Little, however, is known about volume-outcome associations for surgical costs and LOS. We hypothesized that higher provider volume is associated with lower cost and shorter LOS. Methods: Using Taiwan's national data (2001-2012), we conducted a retrospective cohort study of all adults 18-64 years of age who underwent FTT during the study period...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29162216/treatment-regimens-by-pediatric-nephrologists-in-children-with-congenital-nephrogenic-diabetes-insipidus-a-mwpnc-study
#16
Cynthia D'Alessandri-Silva, Melinda Carpenter, John D Mahan
BACKGROUND: Congenital nephrogenic diabetes insipidus (NDI) is a rare genetic disorder affecting urinary concentration. Clinicians have varied medication regimens as well as nutritional plan approaches for these children. MATERIALS AND METHODS: An electronic survey was distributed to member pediatric nephrologists of the Midwest Pediatric Nephrology Consortium via email (n = 179). Questions included types of drugs prescribed, factors contributing to drug choice, common drug combinations given, and dietary/failure to thrive interventions used...
November 22, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29161691/failure-to-thrive-in-the-context-of-carney-complex
#17
Amit Tirosh, Adi Auerbach, Belen Bonella, Phaedon D Zavras, Elena Belyavskaya, Charalampos Lyssikatos, Karen Meir, Ram Weiss, Hagit Daum, Maya B Lodish, David Gillis, Constantine A Stratakis
BACKGROUND/AIMS: Carney complex (CNC) is a rare syndrome associated with multiple tumors and several other unique manifestations. We describe the clinical, genetic, and laboratory findings in a cohort of patients with CNC and failure to thrive (FTT). METHODS: A retrospective case series of pediatric patients with CNC presenting with FTT. RESULTS: We describe a patient with infantile Cushing syndrome (CS) who presented with severe FTT and liver disease; the patient was subsequently diagnosed with CNC...
2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28994410/structure-of-the-conserved-francisella-virulence-protein-fvfa
#18
Subramania Kolappan, Karen Y Lo, Chiao Ling Jennifer Shen, Julian A Guttman, Lisa Craig
Francisella tularensis is a potent human pathogen that invades and survives in macrophage and epithelial cells. Two identical proteins, FTT_0924 from F. tularensis subsp. tularensis and FTL_1286 from F. tularensis subsp. holarctica LVS, have previously been identified as playing a role in protection of the bacteria from osmotic shock and its survival in macrophages. FTT_0924 has been shown to localize to the inner membrane, with its C-terminus exposed to the periplasm. Here, crystal structures of the F. novicida homologue FTN_0802, which we call FvfA, in two crystal forms are reported at 1...
October 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28952374/hospitalization-for-failure-to-thrive-a-prospective-descriptive-report
#19
Catherine Larson-Nath, Nicole St Clair, Praveen Goday
Failure to thrive (FTT) is a common symptom leading to hospitalization of children. Most literature describing this population is from 30 years ago. Since that time the hospitalized population has become more medically complex. We aimed to describe children hospitalized for FTT in a tertiary care pediatric hospital. We prospectively collected demographic, anthropometric, evaluation, and outcome data for 92 consecutive children admitted with FTT. The majority of children grew with behavioral interventions alone (primary nonorganic FTT) and had negative evaluation (n = 63)...
February 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/28946718/effects-of-topical-tamoxifen-on-wound-healing-of-burned-skin-in-rats
#20
Shaban Mehrvarz, Ali Ebrahimi, Hedayat Sahraei, Mohammad Hasan Bagheri, Sima Fazili, Shahram Manoochehry, Hamid Reza Rasouli
BACKGROUND: This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue. METHODS: Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals' back, measuring 2×2×2 cm. In the first group, a 2% tamoxifen ointment was applied to the wound twice daily for 8 weeks...
September 2017: Archives of Plastic Surgery
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