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Food allergic

Javier Molina-Infante, Carolina Gutierrez-Junquera, Edoardo Savarino, Roberto Penagini, Ines Modolell, Ottavia Bartolo, Alicia Prieto-García, Aurelio Mauro, Javier Alcedo, Antonia Perelló, Carlos Guarner-Argente, Noelia Alcaide, Ana M Vegas, Patricia Barros-García, Marianette Murzi-Pulgar, Monica Perona, Javier P Gisbert, Alfredo J Lucendo
OBJECTIVES: Rising trends in eosinophilic esophagitis (EoE) have been repeatedly linked to declining Helicobacter pylori (H. pylori) infection, mostly in retrospective studies. We aimed to prospectively evaluate this inverse association. METHODS: Prospective case-control study conducted in 23 centers. Children and adults naïve to eradication therapy for H. pylori were included. Cases were EoE patients, whereas controls were defined by esophageal symptoms and <5 eos/HPF on esophageal biopsies...
March 15, 2018: American Journal of Gastroenterology
Rosy Wells, A T Fox, Mark Furman
Case reports have described an association between oral food/aeroallergen immunotherapy with the development of eosinophilic oesophagitis (EoE). The underlying mechanism of this is poorly understood, as is the role that both food/aeroallergen sensitisation plays in the pathogenesis of EoE. Specific immunotherapy has a long-standing history of use in the management of moderate/severe seasonal allergic rhinitis (AR), caused by tree/grass pollens. Subcutaneous immunotherapy (SCIT) to grass pollen is less commonly used in children than sublingual immunotherapy (SLIT) or oral immunotherapy for practical reasons...
March 15, 2018: BMJ Case Reports
A Gülsen, U Jappe
We describe a case of a woman who developed three separate episodes of urticaria and ana-phylaxis during exercise after consuming an apple, with immunological evidence that nonspecific lipid transfer proteins (LTP) may have been responsible for these reactions. LTP sensitivity can cause life-threatening allergies and anaphylaxis. Although LTP sensitization is common in Mediterranean countries, the frequency of knowledge and diagnoses is increasing in Europe. Despite the geographic differences, LTP allergy should be kept on sight when facing severe anaphylaxis after consuming LTP-included food...
March 2, 2018: European Annals of Allergy and Clinical Immunology
R Asero, M Piantanida, V Pravettoni
Background. Follow-up data about the onset of novel food allergies in patients allergic to lipid transfer protein (LTP) are missing. We investigated the occurrence of novel allergies over time in LTP hypersensitive patients. Methods. Sixty-seven LTP-allergic patients recommended to avoid foods responsible for systemic reactions and encouraged to eat other sensitizing foods avoiding the association with known co-factors, were re-evaluated after ≥ 1 year to assess the occurrence of allergy to novel foods. IgE to rPru p 3, rBet v 1, and r Phl p 12 were measured...
February 16, 2018: European Annals of Allergy and Clinical Immunology
Jarkko Mäntylä, Tuuli Thomander, Auli Hakulinen, Kaarina Kukkonen, Kati Palosuo, Helena Voutilainen, Anna Pelkonen, Paula Kauppi
INTRODUCTION: The standard care of severe food allergy in both adults and children means avoidance of allergens. In recent years promising results of oral immunotherapy (OIT) have been reported in children. In adults, information on OIT in severe food allergy is very limited. OBJECTIVE: We aimed to study if OIT is possible in adults. METHODS: We report OIT results in 10 adult patients with milk OIT, nine adult patients with peanut OIT, and four adult patients with egg OIT...
March 15, 2018: Immunity, Inflammation and Disease
Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Masaya Takahashi, Hirotaka Minami
The incidence of atopic diseases, including atopic dermatitis (AD), food allergies, allergic rhinitis, and asthma, has increased in recent decades, and currently affects approximately 20% of the population. Atopic march is the development of AD in infancy and subsequent food allergies, allergic rhinitis, and asthma in later childhood. Patients with infantile eczema may develop typical symptoms of AD, allergic rhinitis, and asthma at certain ages. Some patients' symptoms persist for several years, whereas others may have resolution with aging...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Jessica L Peck, E Katherine Larson, Stacy K Silvers
The prevalence of food allergy has risen dramatically in the last two decades. Primary care providers encounter food-allergic children on a daily basis. Although the standard of care has traditionally been strict avoidance of the allergen and advisement to carry an epinephrine autoinjector in case of an accidental exposure resulting in a severe reaction, food allergy research has progressed in the past decade concerning various immunotherapies that may provide an alternate treatment strategy. Oral immunotherapy (OIT), performed under the supervision of an allergist, is the most widely studied of these therapies...
March 12, 2018: Journal of Pediatric Health Care
Shu-Jun Liu, Ting-Ting Wang, Shi-Yu Cao, Ya-Qing Tan, Li-Zhang Chen
OBJECTIVE: To investigate the main risk factors for asthma in Chinese children, and to provide a reference for the prevention and treatment of asthma. METHODS: The databases including CNKI, Wanfang Data, China Biology Medicine disc, VIP Database for Chinese Technical Periodicals, Web of Science, and PubMed were searched for studies on risk factors for asthma in Chinese children published up to September 2017. Stata 12.0 was used for the Meta analysis. RESULTS: A total of 24 case-control studies were included, with 5 309 cases in the case group and 6 404 cases in the control group...
March 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Nissreen E ELBadawy, Randa S Abdel-Latif
Specific immunotherapy (SIT) is one of the important lines for the treatment of food allergy. Efficacy tests for clinical response to SIT are limited and subjective. In this study, we aimed to evaluate the validity of food specific Ig E levels as a biomarker of clinical improvement in children with food allergy treated with oral immunotherapy (OIT). We analysed 184 children with food allergy, 143 had undergone 2 years of food OIT and 41 were on allergen restricted diet and considered as control. All patients were subjected to Double-Blind Placebo-Controlled Food Challenge test (DBPCFC), allergic symptom score calculation, and serum food specific Ig E level before and after oral immunotherapy for treated patients and after 2 year of allergen restricted diet for the control group...
June 2017: Egyptian Journal of Immunology
Xingcui Wang, Lei Zhang, Ying Wang, Xuemei Liu, Hongxia Zhang, Yi Liu, Nan Shen, Junjie Yang, Zhongtao Gai
BACKGROUND: Alterations in the intestinal microbiota have been associated with the development of allergic diseases, such as asthma and food allergies. However, there is no report detailing the role of microbiota alterations in Henoch-Schönlein Purpura (HSP) development. METHOD: A total of 85 children with HSP and 70 healthy children were recruited for this study. Intestinal microbiota composition was analyzed by 16S rRNA gene-based pyrosequencing. Fecal microbial diversity and composition were compared...
March 8, 2018: International Immunopharmacology
Katrina J Allen, Steve L Taylor
Precautionary allergen labeling (PAL) also known as "may contain" labeling has been applied to many packaged food products around the world. PAL is a voluntary form of labeling whose original intent was to help ensure that packaged foods were as safe as possible for allergic consumers by alerting them to the possible presence of allergen residues resulting from the use of shared processing equipment, shared processing facilities, or other industry practices. However, the proliferation of PAL and the myriad of various phrasing used as PAL statements are confusing to consumers and serve to diminish their quality of life...
March 2018: Journal of Allergy and Clinical Immunology in Practice
Amy M Scurlock, Stacie M Jones
Advances in food allergy diagnosis, management, prevention and therapeutic interventions have been significant over the past two decades. Evidence based national and international guidelines have streamlined food allergy diagnosis and management, while paradigm shifting work in primary prevention of peanut allergy has resulted in significant modifications in the approach to early food introduction in infants and toddlers. Innovative investigation of food allergy epidemiology, systems biology, impact, and management has provided important insights...
March 7, 2018: Journal of Allergy and Clinical Immunology
Xiaodong Jiang, Chun Shen, Yuan Dai, Fan Jiang, Shenghui Li, Xiaoming Shen, Yan Hu, Fei Li
BACKGROUND: The relationship between food allergy and respiratory allergy, and attention-deficit/hyperactivity disorder (ADHD) in children is rarely investigated. Our objective is to determine whether early food allergy and respiratory allergy symptoms are associated with the prevalence of ADHD in Chinese school-age children. METHODS: This cross-sectional study was conducted in school-age children using cluster-stratified methods from nine cities across China between November and December 2005...
March 9, 2018: Pediatric Allergy and Immunology
Edyta Krzych-Fałta, Konrad Furmańczyk, Aneta Tomaszewska, Dominik Olejniczak, Bolesław Samoliński, Urszula Samolińska-Zawisza
BACKGROUND: The hygiene hypothesis proposed by Strachan in the 1980s clearly emphasized the role of microorganisms in atopy prevention. OBJECTIVES: The study objective was to assess the preventive role of probiotics in patients with allergic rhinitis, bronchial asthma, atopic dermatitis, and/or food allergy. MATERIAL AND METHODS: The methods used in the study were the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires for 6-7- and 13-14-year-olds and the European Community Respiratory Health Survey II (ECRHS II) questionnaire targeted for the 20-44 age group...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Rajia Bahri, Adnan Custovic, Peter Korosec, Marina Tsoumani, Martin Barron, Jiakai Wu, Rebekah Sayers, Alf Weimann, Monica Ruiz-Garcia, Nandinee Patel, Abigail Robb, Mohamed H Shamji, Sara Fontanella, Mira Silar, E N Clare Mills, Angela Simpson, Paul J Turner, Silvia Bulfone-Paus
BACKGROUND: Food allergy is an increasing public health issue and the commonest cause of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence of allergen-specific IgE, significantly overestimating the rate of true clinical allergy resulting in over-diagnosis and adverse impact on health-related quality of life. OBJECTIVE: To undertake initial validation and assessment of a novel diagnostic tool, the mast cell activation test (MAT)...
March 5, 2018: Journal of Allergy and Clinical Immunology
Takeshi Matsubara, Hiroshi Iwamoto, Yuki Nakazato, Tomoyuki Okamoto, Tatsuya Ehara, Hirohisa Izumi, Yasuhiro Takeda
BACKGROUND: Epicutaneous sensitization to food allergens can occur through defective skin barriers. However, the relationship between oral tolerance and epicutaneous sensitization remains to be elucidated. We aimed to determine whether prior oral exposure to whey proteins or their hydrolysates prevents epicutaneous sensitization and subsequent food allergic reaction to the whey protein, β-lactoglobulin (β-LG), and investigated the underlying mechanisms. METHODS: BALB/c mice were given whey protein concentrate (WPC), two kinds of partial whey protein hydrolysate (PWH1 or PWH2), or extensive whey protein hydrolysate (EWH) in drinking water for 21 days...
March 8, 2018: Pediatric Allergy and Immunology
Julia Upton, Anna Nowak-Wegrzyn
Baked milk (BM) and baked egg (BE) diets are increasingly used in the management of milk and egg allergy, rather than avoidance. Children with tolerance versus reactivity to BM and BE may have smaller skin prick test and lower specific IgE, and BM-tolerant children have less basophil reactivity and more peripheral T regulatory cells. However, most milk- and egg-allergic children tolerate BM and BE and an individual's reactivity is unpredictable. Non-reactivity is due to conformational changes in the allergens...
March 8, 2018: Clinical Reviews in Allergy & Immunology
Keerthi Reddy, Mary Kearns, Santiago Alvarez-Arango, Ismael Carrillo-Martin, Nathaly Cuervo-Pardo, Lyda Cuervo-Pardo, Ves Dimov, David M Lang, Sonia Lopez-Alvarez, Brian Schroer, Kaushik Mohan, Mark Dula, Simin Zheng, Claudia Kozinetz, Alexei Gonzalez-Estrada
BACKGROUND: Food allergy affects an estimated 8% of children and 3% of adults in the US. Food-allergic individuals increasingly use the web for medical information. We sought to determine the educational quality of food allergy YouTube videos. METHODS: We performed a YouTube search using keywords "food allergy" and "food allergies". The 300 most viewed videos were included and analyzed for characteristics, source, and content. Source was further classified as health care provider, alternative medicine provider, patient, company, media, and professional society...
March 7, 2018: Pediatric Allergy and Immunology
Selçuk Yazıcı, Hikmet Tekin Nacaroglu, Semiha Bahçeci Erdem, Sait Karaman, Demet Can
We present a 13-year-old male childallergic to three different plants (Salvia officinalis, Mentha piperita and Origanum onites L.) of Lamiaceae family. The patient developed angioedema 20-30 minutes after eating chicken meat with cheddar cheese. There was no history of allergy. Oral food challenge (OFC) with both cheddar cheese and chicken meat was negative. Skin tests for inhalant allergens were negative. 3 weeks later, the patient was admitted with angioedema after drinking sage tea. OFC with sage was applied and angioedema was observed...
February 2018: Iranian Journal of Allergy, Asthma, and Immunology
Lauren M Kao, Julie Wang, Olga Kagan, Anne Russell, S Shahzad Mustafa, Diane Houdek, Bridget Smith, Ruchi Gupta
BACKGROUND: Although school health care professionals are integral to the management of students with food allergy, their views on school food allergy policies have not yet been reported. OBJECTIVE: To characterize food allergy policies currently being used in schools and their utility and potential barriers to implementation from the perspective of school health care professionals. METHODS: An electronic survey was disseminated to school nurses at the 2016 National Association of School Nurses meeting and through the Allergy and Asthma Network listserv...
March 2018: Annals of Allergy, Asthma & Immunology
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