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https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#1
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28523203/mycobacterium-avium-subsp-paratuberculosis-induces-specific-ige-production-in-japanese-people-with-allergies
#2
D Cossu, S Otsubo, Y Otsubo, S Eda, T Suzuki, Y Iwao, T Kuribayashi, S Yamamoto, L A Sechi, E Momotani
Background. The prevalence of allergies is steadily increasing worldwide; however, the pathogenesis is still unclear. We hypothesized that Mycobacterium avium subsp. paratuberculosis (MAP) may contribute to allergy development. This organism can be present in dairy foods, it can elicit an immunomodulatory switch from a Th1 to a Th2 response, and it has been speculated that it is linked to several human autoimmune diseases. To determine the contribution, sera from 99 individuals with various atopic disorders and 45 healthy nonallergic controls were assessed for total IgE levels and successively for MAP-specific IgE by ELISA...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28521324/the-role-of-hydrolyzed-formula-in-allergy-prevention
#3
Michael D Cabana
Asthma, eczema, food allergy, and allergic rhinitis are some of the most common pediatric, chronic conditions in the world. Breastfeeding is the optimal way to feed all infants. For those infants who are exposed to infant formula, some studies suggest that certain partially hydrolyzed or extensively hydrolyzed formulas may decrease the risk of allergic disease compared to nonhydrolyzed formulas for children with a family history of atopic disease. Overall, there is some evidence to suggest that partially hydrolyzed whey formulas and extensively hydrolyzed casein formulas may decrease the risk of developing eczema for infants at high risk of allergic disease...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28521318/breastfeeding-childhood-asthma-and-allergic-disease
#4
Wendy H Oddy
The worldwide prevalence of childhood asthma has been increasing considerably, and the protection afforded by breastfeeding in its development has been the subject of controversy for more than 80 years. Previous systematic reviews have generally found a protective effect of breastfeeding on allergic outcomes, although many studies have methodological limitations. Although breastfeeding is protective against lower respiratory tract infection during infancy, such protection has not been demonstrated for asthma in all studies...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28521317/mechanisms-of-tolerance-induction
#5
Anna Nowak-Węgrzyn, Pantipa Chatchatee
Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28521316/introduction-of-complementary-foods-to-infants
#6
Christina West
While earlier food allergy prevention strategies implemented avoidance of allergenic foods in infancy, the current paradigm is shifting from avoidance to controlled exposure. This review focuses on the outcome of recent randomized controlled trials, which have examined the early introduction of allergenic foods for allergy prevention, and discusses the implementation of results in clinical practice. In infants at high risk of allergic disease, there is now direct evidence that regular early peanut consumption will reduce the prevalence of peanut allergy, compared to avoidance...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28516366/patient-centered-outcomes-in-food-allergy
#7
REVIEW
Brooke I Polk, Chitra Dinakar
PURPOSE OF REVIEW: Food allergy prevalence is increasing very rapidly, causing a significant disease burden. The threat of severe allergic reactions occurring unexpectedly and in settings that are not equipped to recognize and treat anaphylaxis is a constant source of worry for individuals and families with food allergies. Inadequate knowledge and understanding in the community significantly impairs the overall quality of life of these individuals and families. Additionally, families face challenges in finding and affording appropriate allergen-free foods...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28515404/insolubility-and-alteration-of-allergenic-activity-of-wheat-proteins-in-processed-foods
#8
Kajiyo Tanaka, Yuuki Kanie, Michita Naitou, Misa Suzuki, Harue Umemura, Kazunori Tagami, Kazunori Sakai, Tomoko Furuta, Chikako Yamada, Hidehiko Izumi, Tomoharu Yokooji, Hiroaki Matsuo, Komei Ito
BACKGROUND: Food processing causes decomposition, denaturation or polymerization of protein, which may alter an allergic reaction. This study aimed to investigate the insolubility and alteration of wheat allergens in processed foods and the reactivity to patient sera. METHODS: We extracted proteins from wheat flour, udon and bread using different extracts and conducted SDS-polyacrylamide gel electrophoresis. IgE-immunoblotting was also conducted using sera from children with wheat allergy...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28514997/the-prevalence-of-food-allergy-and-other-allergic-diseases-in-early-childhood-in-a-population-based-study-healthnuts-age-4-year-follow-up
#9
Rachel L Peters, Jennifer J Koplin, Lyle C Gurrin, Shyamali C Dharmage, Melissa Wake, Anne-Louise Ponsonby, Mimi L K Tang, Adrian J Lowe, Melanie Matheson, Terence Dwyer, Katrina J Allen
BACKGROUND: The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse. OBJECTIVE: This study aimed to report the updated prevalence of food allergy at age 1 year from the whole cohort, and to report the prevalence of food allergy, asthma, eczema, and allergic rhinitis at age 4 years...
April 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28512288/lactic-acid-bacteria-specific-induction-of-cd4-foxp3-t-cells-ameliorates-shrimp-tropomyosin-induced-allergic-response-in-mice-via-suppression-of-mtor-signaling
#10
Linglin Fu, Jixiang Peng, Shushu Zhao, Yan Zhang, Xiurong Su, Yanbo Wang
The beneficial effects of probiotics have been described in allergic sensitization and diseases; however, many questions remain unanswered, such as characteristics of the most effective strains in modulation of allergic responses and how orally administered probiotics affect the systemic immune system. In the present work, oral administration of five lactic acid bacteria strains showed variable effects on protection against the allergic reaction in a mouse model of food allergy to shrimp tropomyosin (ST). The most effective anti-allergic strain, Bacillus coagulans 09...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28509714/preventing-occupational-skin-disease-a-review-of-training-programs
#11
Bethany Zack, Victoria H Arrandale, D Linn Holness
Occupational contact dermatitis (OCD) is a common occupational disease that impacts a variety of worker groups. Skin protection and disease prevention training programs have shown promise for improving prevention practices and reducing the incidence of OCD. This review details the features of training programs for primary prevention of OCD and identifies gaps in the literature. Twelve studies were identified for in-depth review: many studies included wet workers employed in health care, hairdressing, cleaning, and food preparation; 1 program featured manufacturing workers...
May 2017: Dermatitis
https://www.readbyqxmd.com/read/28507730/application-of-the-adverse-outcome-pathway-aop-concept-to-structure-the-available-in-vivo-and-in-vitro-mechanistic-data-for-allergic-sensitization-to-food-proteins
#12
REVIEW
Jolanda H M van Bilsen, Edyta Sienkiewicz-Szłapka, Daniel Lozano-Ojalvo, Linette E M Willemsen, Celia M Antunes, Elena Molina, Joost J Smit, Barbara Wróblewska, Harry J Wichers, Edward F Knol, Gregory S Ladics, Raymond H H Pieters, Sandra Denery-Papini, Yvonne M Vissers, Simona L Bavaro, Colette Larré, Kitty C M Verhoeckx, Erwin L Roggen
BACKGROUND: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28507485/the-influence-of-dietary-immunomodulatory-factors-on-development-of-food-allergy-in-children
#13
REVIEW
Izabela Sardecka, Aneta Krogulska, Ewa Toporowska-Kowalska
In the last few years many studies have been conducted on the role of dietary and environmental factors in the prevention of allergic diseases among children. Many studies have shown that the diet of pregnant women and children in their early postnatal life, rich in antioxidants, vitamin D, and fatty acids is beneficial as it reduces the risk of allergy in their future life. Moreover, there are many reports about the main role of gut microbiota and probiotics in the allergy prevention, what can indicate new ways of procedures in allergic diseases...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28506355/-effects-of-adipose-derived-stem-cells-and-non-methylated-cpg-oligodeoxynucleotides-on-peripheral-blood-cd4-cd25-regulatory-t-cells-in-young-mice-with-food-allergy
#14
Xu-Lin Chen, Cheng-Zhong Zheng
OBJECTIVE: To investigate the effects of adipose-derived stem cells (ADSC) and non-methylated CpG-oligodeoxynucleotides (CpG-ODN) on the expression of peripheral blood CD4(+)CD25(+) regulatory T (Treg) cells in young mice with food allergy, as well as their immune intervention effects. METHODS: A total of 40 female BALB/c mice were randomly divided into control group, allergic group, ADSC treatment group, and CpG-ODN treatment group, with 10 mice in each group. A mouse model of food allergy was established by intraperitoneal injection and intragastric administration of ovalbumin (OVA) for sensitization and challenge...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28503050/fingerroot-boesenbergia-rotunda-and-its-aphrodisiac-activity
#15
REVIEW
Oranun Ongwisespaiboon, Wannee Jiraungkoorskul
Boesenbergia rotunda (Family: Zingiberaceae) as known as fingerroot is a daily food ingredient and traditional medicinal plant in Southeast Asia and Indo-China. It has been shown to possess anti-allergic, antibacterial, anticancer, anti-inflammatory, antioxidant, and antiulcer activities and also shown wound healing. Its common phytochemical components include alkaloids, essential oils, flavonoids, and phenolics. This plant is rich in boesenbergin, krachaizin, panduratin, and pinostrobin, all of which has been reported to contribute to its remedial properties including aphrodisiac property...
January 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28502295/-lactobacillus-rhamnosus-gg-improves-symptoms-and-its-mechnism-in-mice-with-ovalbumin-induced-food-allergy
#16
Shuanfeng Fang, Yu Zhang, Yun Zhang, Xiaohua Zhu, Bei Yie
Objective To investigate the effect of Lactobacillus rhamnosus GG (LGG) on peripheral blood IL-4/IFN-γ in mice with ovalbumin-induced food allergy. Methods The mice with food allergy were divided into 3 groups (n=10 in each group): food allergy model group, low-dose LGG group (1×10(8) CFU/mL, 200 μL/d) and high-dose LGG group (1×10(9) CFU/mL, 200 μL/d). The healthy mice (n=10) served as a control group. Mice in the LGG groups were given LGG for consecutive 22 days after modeling. The control mice and the food allergy model mice were given normal saline instead of LGG...
May 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28500661/is-mealworm-or-shrimp-allergy-indicative-for-food-allergy-to-insects
#17
Henrike Chp Broekman, André C Knulst, Govardus de Jong, Marco Gaspari, Constance F den Hartog Jager, Geert F Houben, Kitty Cm Verhoeckx
SCOPE: The growing world population is a key driver for the exploration of sustainable protein sources to ensure food security. Mealworm and other insects are promising candidates. Previously we found that shrimp allergic patients are at risk for mealworm allergy, and that mealworm can induce a primary allergy 3.This study set out to investigate the allergenic potential of edible insects, suggested for human consumption by agencies such as WHO/FAO, in both the shrimp (potentially cross-reactive) and primary mealworm allergic population...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28500319/airway-microbial-diversity-is-inversely-associated-with-mite-sensitized-rhinitis-and-asthma-in-early-childhood
#18
Chih-Yung Chiu, Yi-Ling Chan, Yu-Shuen Tsai, Ssu-An Chen, Chia-Jung Wang, Kuan-Fu Chen, I-Fang Chung
Microbiota plays an important role in regulating immune responses associated with atopic diseases. We sought to evaluate relationships among airway microbiota, serum IgE levels, allergic sensitization and their relevance to rhinitis and asthma. Microbial characterization was performed using Illumina-based 16S rRNA gene sequencing of 87 throat swabs collected from children with asthma (n = 32) and rhinitis (n = 23), and from healthy controls (n = 32). Data analysis was performed using QIIME (Quantitative Insights Into Microbial Ecology) v1...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28497679/disappearance-of-severe-oral-allergy-syndrome-following-omalizumab-treatment
#19
R Asero
The first case of disappearance of apple-induced oral allergy syndrome in a birch pollen-allergic patient following omalizumab treatment is reported. This observation in a case of type 2 food allergy suggests that omalizumab is potentially an effective preventive treatment for patients with severe, type 1 food allergies.
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28495789/dietary-nondigestible-oligosaccharides-and-bifidobacterium-breve-m-16v-suppress-allergic-inflammation-in-intestine-via-targeting-dendritic-cell-maturation
#20
Sander de Kivit, Atanaska I Kostadinova, JoAnn Kerperien, Mary E Morgan, Veronica Ayechu Muruzabal, Gerard A Hofman, Leon M J Knippels, Aletta D Kraneveld, Johan Garssen, Linette E M Willemsen
Dietary intervention with short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V (Bb) (GF/Bb) suppresses food allergic symptoms in mice, potentially via intestinal epithelial cell (IEC)-derived galectin-9. Furthermore, in vitro studies showed galacto- and fructo-oligosaccharides (GF) to enhance the immunomodulatory capacity of a TLR9 ligand representing bacterial CpG DNA when exposed to IEC. In this study, we investigated whether GF/Bb modulates dendritic cells (DCs) and subsequent Th2 and regulatory T cell (Treg) frequency in the small intestinal lamina propria (SI-LP)...
May 11, 2017: Journal of Leukocyte Biology
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